Cholesterol metabolism all genes sink node genes ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● maximum = 4 maximum = 2 2 1 s>
10 0 0 10 log −1 −2 group 1 group 2 group 3 group 4 group 5 group 6 group 7 group 8 Cholesterol_metabolism genes with data NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism sink nodes NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 1 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 2 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 3 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 4 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 5 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 6 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 7 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE Cholesterol_metabolism group 8 NCEH1 ABCA1 SOAT1 ABCA1 APOA1 APOA1 APOA1 CD36 LDLR APOC1 LIPG LCAT LPL LIPC APOC2 PLTP LPL APOH LPA CETP ANGPTL3 APOC1 ANGPTL8 APOA1 APOB ABCA1 SCARB1 SORT1 LDLR LDLRAP1 PCSK9 SORT1 LDLR MYLIP SORT1 PCSK9 APOE LRP1 PCSK9 LDLR LDLR LRPAP1 LIPA CYP27A1 STARD3 VDAC1 TSPO STAR NPC2 VDAC1 STARD3 NPC1 VAPB OSBPL5 SORT1 APOB SOAT1 CYP7A1 ABCB11 ABCG5 APOA1 APOB LPA APOB APOB APOB APOA1 APOB APOA2 APOB APOE APOC1 APOE APOA2 APOC1 APOC1 APOE APOA4 APOE APOE