THE UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER Discovery Research Annual Report 2020

Pandemic Partnerships Teaming Up to Tame the Coronavirus

TURNING RESEARCH INTO CURES UNM Health Sciences Center UNM HEALTH SCIENCES CENTER Research Annual Report 2020 VISION Managing Editor Michael Haederle The University of New Mexico Health Sciences Center will

Design work with community partners to help New Mexico make more Jana Fothergill progress in health and health equity than any other state. Contributing Editors Rebecca Roybal Jones MISSION Yamhilette Licon Muñoz We will provide an opportunity for New Mexicans to obtain an Robert Oliver Rebecca Sena excellent education in health sciences, advance health discovery Michele Sequeira and innovation in the most important areas of human health and Kara Leasure Shanley ensure that all populations in New Mexico have access to the Photography highest-quality health care. Seth Fuller iStock by Dreamstime CORE VALUES The UNM Health Sciences Center’s mission is guided by our values of excellence in education, patient care and research, commitment to service, quality and safety, integrity and accountability, respect and compassion for all people, teamwork and collaboration – and providing hope for those we serve.

©2020 The University of New Mexico Health Sciences Center Office of Research Published by the HSC Communications Department Special thanks to Aida Andujo, James MacFarlane and Joshua L. Smith for their assistance Printed by Starline Printing, Albuquerque, N.M. See inside back cover for information on donating to bioscience research at The University of New Mexico.

Contact voice 505-272-6950 fax 505-272-8738 hsc.unm.edu/research the university of new mexico health sciences center CONTENTS

LETTERS Richard S. Larson, MD, PhD Research Executive Vice Chancellor Annual Report Vice Chancellor for Research 2 Martha Cole McGrew, MD 2020 Interim Dean, School of Medicine 3 Christine Kasper, PhD, RN Dean, College of Nursing 4 Donald Godwin, PhD Dean, College of Pharmacy 5 Tracie Collins, MD, MPH Dean, College of Population Health 6

FEATURES Pandemic Partnerships 7 When COVID-19 Came to New Mexico, Health Sciences Researchers Teamed Up to Study the Novel Coronavirus Michael Haederle, Michele Sequeira and Kara Leasure Shanley Cerebral Support 11 Domenici Hall to Host Brain Injury and Substance Use Disorder Research Robert Oliver Major Milestone 13 UNM to Launch New Alzheimer's Disease Research Center Michael Haederle Gauging the Risks 14 UNM METALS Superfund Study Evaluates Toxic Exposures Rebecca Sena Diving into the Data 15 New College of Nursing Research Sheds Light on Health Policy Michael Haederle Storytelling Solution 16 Developing Unique Interventions to Stem Teen Suicide Rebecca Roybal Jones Double Honors 17 Angela Wandinger-Ness Receives 2020 Awards Michael Haederle Sound Investment 18 UNM's T32 Programs Provide Critical Support Yamhilette Licon Muñoz 2020 HSC Training Grants 20 2020 Research Excellence Awards 24 2020 HSC Grant Listings 27 Information for Donors Inside Back Cover

1 unm health sciences center research annual report 2020 ’m very pleased to research in underserved and rural report that the UNM areas throughout New Mexico, where I Health Sciences Center they are improving access to care, was awarded a record $205.8 million addressing chronic disease and in external research funding during increasing access to clinical trials and FY 2020, representing net growth in state-of-the-art technologies. 15 of the past 16 years. Research distinguishes academic This remarkable achievement is health centers like ours from other health care providers. In fact, the challenges faced by academic health integration of research, education especially significant given the epic centers like ours in the face of the and clinical care at academic richard s. larson, md, phd COVID-19 pandemic. I’m extremely health centers drives much of the proud of the way our faculty, staff innovation in the U.S. health care Executive and students stepped up to keep system. We should all be proud of our our research enterprise on track contributions to the advancement of Vice Chancellor this year. health and health care in our nation. for Health We recently received a third Through our grant funding, the UNM HSC research mission provides Sciences Translational Science Award from tremendous economic impact and five-year renewal of our Clinical and the National Institutes of Health, job creation for New Mexicans. New Vice Chancellor and in coming months we anticipate discoveries and patents stimulate renewal of the UNM Center’s business creation and support a for Research comprehensive designation by the growing bioscience industry. Most National Cancer Institute. important, our research has a These achievements are truly a powerful impact on health care, both tribute to your drive and hard work. locally and nationally. UNM HSC scientists are advancing As I frequently remind friends and the understanding, diagnosis colleagues, research brings hope, and and treatment of many diseases, including asthma, cancer, stroke, we will play a vital role in improving I’m confident that in the coming year Alzheimer’s disease, substance health care in New Mexico, the U.S. abuse, heart disease and behavioral and the world. █ health conditions. Our work extends beyond the lab: our faculty members conduct

2 unm health sciences center research annual report 2020 Interim Dean, School of Medicine

he COVID-19 pandemic assumed leadership of the Biomedical has affected every facet Sciences Graduate Program and T of our lives, and chal- led efforts to adapt to pandemic lenges us in ways most restrictions and integrate anti-racism of us have never experienced. Since education into the curriculum. becoming interim dean in July, I have Justin Baca, MD, PhD, associate been impressed with our researchers’ professor of Emergency Medicine, efforts to develop vaccines, find has been named director of the MD/ effective therapeutics and devise PhD degree program. I’m excited by sterilization methods to preserve the prospects for continued growth personal protective equipment. of this program under his leadership. martha cole mcgrew, md The Department of Neurosciences, I’d also like to acknowledge our led by Bill Shuttleworth, PhD, has NIH-funded training programs in been continually funded for its Center alcohol research, infectious disease Interim Dean for Brain Recovery and Repair and and , cardiovascular dis- the New Mexico Alcohol Research ease and academic science education School of Center, as well as a National Institutes and research. These programs have Medicine of Health training grant. The depart- greatly enhanced research education ment ranks 17th nationally in NIH for our trainees. neurosciences research funding. Finally, recognition is due to The Research Education Office Angela Wandinger-Ness, PhD, has fostered undergraduate, pre-doc- professor in the Department of toral and post-doctoral biomedical Pathology, who was honored with training and career development. the 2020 Presidential Award for Congratulations to senior associate Excellence in Science, Mathematics dean Tom Resta, PhD, and his team and Engineering Mentoring. She for overcoming the many challenges also received the 2020 American imposed by the ongoing pandemic. Association for the Advancement of Jennifer Gillette, PhD, associate Science Lifetime Mentor Award. We professor in the Department of are fortunate to have her as a member Pathology, helped transform the of our faculty. Undergraduate Pipeline Network Thanks to everyone who has made into a completely remote experience, these research programs a success. including a virtual symposium that They are central to our institution’s highlighted some of the nation’s most mission and promise to enhance promising student researchers. the health and well-being of New Laura Gonzalez Bosc, PhD, pro- Mexicans. █ fessor of Cell Biology & Physiology,

unm health sciences center 2020 / letters 3 he College of Nursing Her research focuses on clinical is adapting in the knowledge development and con- T face of the COVID-19 tinuity of care for wounded service pandemic as it prepares the next members, military and veteran care- generation of nurses to address giver burden, health promotion and urgent health care needs and improve self-care management for those living health for New Mexicans, the nation with complex chronic conditions. and the world. Dr. Watts-Kelley will further our Nurses, consistently rated as the goal of being recognized as a premier most trusted health care profession- Nursing Research Intensive College, als, have an obligation to develop new as our scientific investigations look christine kasper, phd, rn approaches and methods through our at health through a nursing lens and practice and research. approach urgent health care needs Dean I’m pleased to welcome Patricia with our interdisciplinary approach. Watts-Kelley, PhD, RN, FNP-BC, Our faculty in the Departments College of to the College as associate dean for of Bio-Behavioral Health and Rural Nursing Research and Scholarship. She brings Health and Equity have signature extensive research and mentoring strengths in health care disparities experience that will grow our schol- and equity, oncology and toxicology, arship and research programs while genomics, self-management of increasing our extramural funding. complex chronic conditions, military Dr. Watts-Kelley is a retired Navy and veteran health, gerontology and captain who has held research and caregiver burden, eHealth, health leadership positions within the services and policy research. federal government, including health We are proud of our outstanding sciences officer in the Department of alumni, who are changing the face of Veterans Affairs Office of Research health care around the world. You’ll & Development. She also held find UNM nurses in neonatal and the position of deputy director of geriatric units across the nation and Nursing and Allied Health Research in hospitals and academic health cen- at the Navy Medicine Headquarters. ters around the globe. Our graduates She served as the first Navy executive lead military medical commands, director of the TriService Nursing schools of nursing, national nursing Research Program and she was organizations, health care systems director of research services at the and federal agencies. National Naval Medical Center. Onward and upward! █

4 unm health sciences center research annual report 2020 ollege of Pharmacy draws on longstanding partnerships researchers are com- with indigenous communities C mitted to improving to study the health implications the health of New Mexicans, including associated with exposure to wastes our most vulnerable populations, and from abandoned mines, combined tackling the world’s most challenging with microplastic and other plastic and public health issues. In the last degradation products, and most fiscal year they received more than $10 importantly, to develop critical million in extramural funding. mitigation strategies. Beyond dollars, 2020 was a year The College also received an NIH that demonstrated the responsiveness P20 Center of Biomedical Research donald godwin, phd of College researchers and the impact Excellence grant focusing on the that our research has had during a adverse health outcomes of metal global pandemic. When COVID-19 contaminants in the Southwest, as Dean began to spread throughout New well as on harnessing the chemical Mexico last spring, our researchers properties of metals for therapeutic College of jumped into action. and nutritional purposes. Pharmacy The New Mexico Poison and Our substance abuse disorder Drug Information Center teamed up research focuses on prenatal alcohol with the Department of Health to exposure, epigenetic studies and establish the state’s COVID-19 hotline naloxone distribution. We also had to communicate rapidly evolving continued success in the both clinical information. The team also alerted and foundational research in cardio- the Food and Drug Administration vascular disease, infectious disease to a rash of methanol-based hand (particularly HIV and vaccines) and sanitizer poisonings, which helped pharmaceutical dosage formulation to prompt a nationwide warning and studies. eventual product recalls. Clearly, the impact of our research Other researchers received reaches throughout New Mexico and National Institutes of Health funding the U.S., and I am very proud to work to explore the impact of increased with such talented and dedicated COVID-19 related stress across faculty, staff and students across minority communities already the research spectrum to translate affected by historical trauma. biomedical and pharmaceutical The College continued its envi- science discoveries into improved ronmental health research with the patient care. █ renewal of our NIH P50 center, which

unm health sciences center 2019 / letters 5 he COVID-19 research focusing on organic farmers, pandemic has posed a subgroup of agricultural workers T significant challenges who have been neglected by national for us this year in the College of injury and illness surveillance sys- Population Health – but the good tems. His team has established a new news is we have seen significant Assessment, Planning & Evaluation advances in our research mission Unit (APEU) that provides technical alongside the growth of enrollment assistance to community organiza- in our degree programs. tions and state agencies. I’m pleased that our signature Assistant professor Laura Nervi, tracie collins, md, mph Transdisciplinary Research, Equity PhD, MPH, MSSc, partners with and Engagement Center for APEU in several projects, leading Advancing Behavioral Health – the cooperation with a community Dean TREE Center – has a received sup- primary clinic in Albuquerque and College of plemental grant funding to develop a Clinical & Translational Science COVID-related infectious disease Center grant to address language Population modeling. and health literacy barriers among Assistant professor Shannon Spanish speakers through a smart-as- Health Sanchez-Youngman, PhD, received sisted learning program. She also TREE Center supplemental funding continues a line of research on global for her a partnership with the San health policies. Miguel Family and Community I’ve continued to develop a project Health Council in which she helped I started while at the KU School of teens in Las Vegas, N.M., write and Medicine in Wichita involving the produce digital story frameworks use of a smart phone app to promote involving their experiences related healthy eating to address chronic to the risk factors associated with conditions like peripheral artery suicide. It’s hoped the intervention disease in overweight adults. We hope will promote new ideas for suicide to see additional testing to gauge its prevention. long-term effectiveness. Elsewhere in the College, I’m extremely proud of our associate professor Francisco Soto College’s research achievements, and Mas, MD, PhD, MPH, is conducting I’m looking forward to seeing where occupational safety and health they will lead in the coming year. █

6 unm health sciences center research annual report 2020 Pandemic Partnerships When COVID-19 Came to New Mexico, Health Sciences Researchers Teamed Up to Study the Novel Coronavirus

By Michael Haederle, Michele Sequeira and Kara Leasure Shanley

s the COVID-19 pandemic chemical properties of azithromycin Oprea classified each drug spread around the globe and might be key. Both molecule according to which viral last spring, University of are weak bases, with a pH higher than proteins it might target, enabling him New Mexico Health Sciences Center 7.0. They suspect the drugs neutralize to pinpoint the mechanism by which Aresearchers sprang into action to acids within endosomes – tiny it might disable a virus – a critical study the novel coronavirus and membrane-bound compartments first step. He partnered with Larry search for lifesaving treatments and inside the lung cells – that can trigger Sklar, PhD, Distinguished Professor vaccines. inflammation. in the Department of Pathology and For some, the pandemic was an “Even small changes in pH change director of the Center for Molecular occasion to revisit earlier work. the ways those sites in the cells Discovery, which maintains a Graham Timmins and Vojo Deretic work,” Timmins says. “We think collection of drug samples. posted a previously unpublished that’s the way these drugs work.” “Tudor identified molecules in the paper suggesting that the common In another collaboration, a trio of library that would be tested,” said antibiotics azithromycin and cipro- University of New Mexico scientists Sklar, who screened them using a floxacin might have lung-protecting turned to machine learning to cull highly efficient method called assay properties. through a “library” of thousands Timmins a professor in the College FDA-approved drugs to identify of Pharmacy, and Deretic, professor candidates that could be repurposed and chair of the Department of as treatments for the COVID-19 Molecular & , . reported on a decade-old study of The effort was launched in late azithromycin as a treatment for cystic March, when the team started fibrosis patients, who commonly looking for – and testing – known suffer from lung . drugs that might have antiviral Azithromycin alleviates symptoms properties, said Tudor Oprea, MD, of the disease, which inflames the PhD, professor and chief of the tissue lining the bronchial tubes, but Translational Informatics Division in it appears to help even when patients the Department of Internal Medicine. don’t have an active infection. Oprea and his team used sophis- Similarly, when the coronavirus ticated computational methods assaults the lungs, they become to comb through the university’s inflamed as the body mounts a DrugCentral database, which tracks ferocious immune response, but run- drugs approved by the U.S. Food and away inflammation can turn deadly, Drug Administration, as well as those causing multiple organ failure. approved for use elsewhere in the Timmins and Deretic think the world.

unm health sciences center 2020 / pandemic response 7 miniaturization. Drug candidates Dinwiddie, an assistant professor in were then passed on to Steven the UNM Department of Pediatrics, Bradfute, PhD, assistant professor in sequenced coronavirus samples in his UNM’s Center for Global Health, who molecular genomics lab. tested them against the live virus in Dinwiddie collaborated in the his Biosafety Level 3 laboratory. analysis with Domman, PhD, an The UNM team then shared its assistant professor in the Department list of candidates with the National of Internal Medicine who specializes Center for Advancing Translational in genomic epidemiology and has had Sciences (NCATS) to see whether prior experience following outbreaks NCATS could confirm their findings of cholera around the world. As SARS-CoV-2 coronavirus repro- duces, variations appear in its genetic code. Accumulating over time, these changes are like fingerprints, leaving a telltale trail of clues about where the virus has been – and where it might be headed. HSC researchers Darrell L. Dinwiddie, PhD, and Daryl Domman, PhD, took on the role of genomic detectives to help crack the case.

8 unm health sciences center research annual report 2020 They partnered with SARS-CoV-2 SPHERES, a national consortium of research universities and public Steven Bradfute, PhD Vojo Deretic, PhD health departments sponsored by the National Center for Emerging and Zoonotic Infectious Diseases (a branch of the Centers for Disease Control and Prevention) that pooled crucial information about the virus. The coronavirus genome is encoded in strands of a molecule called RNA. Minor changes in the sequence of nucleotides within the Bryce Chackerian, PhD Darrell Dinwiddie, PhD strand provide information about how closely related one viral sample is to another. how quickly it changes. Based on that The consortium used these information we can make predictions samples to create a viral family tree. about how far back different samples A preliminary analysis of samples have gone.” collected in New Mexico suggested Meanwhile, in the Department of there were multiple introductions Molecular Genetics & Microbiology, of the virus into the state, which is longtime collaborators David consistent with early reports of cases Peabody, PhD, and Bryce Chackerian, Tudor Opea, PhD among people who had traveled PhD, joined the worldwide race to abroad or domestically. develop a vaccine to prevent COVID- Genomic variation in viral 19 infections. reproduction is a natural process. Over the years they have used “For the SARS-CoV-2 the rate of virus-like particles to tailor vaccines genomic change has been fairly that can attack a host of different stable,” Dinwiddie said. “We know targets, including human papilloma- virus, malaria and even metastatic breast cancer cells. In this case, Peabody said, “We Christina Salas, PhD make a virus-like particle that displays on its surface bits of SARS-CoV-2, and if those bits of SARS-CoV-2 elicit antibodies that neutralize the virus, that’s a vaccine.” The pair partnered with Bradfute’s lab at the Center for Global Health, and Kathryn Frietze, PhD, and Alison Kell, PhD, in Molecular Genetics & Microbiology to test their vaccine candidates. Graham Timmons, PhD

unm health sciences center 2020 / pandemic response 9 shields, most of which found their way to the Navajo Nation. In August, Salas and flight nurse Laura Kief Shaffer, her partner on the mask-printing project, were featured among “The Badass 50, Healthcare Workers Who Are Saving the Day” in cultured cells to that contaminated InStyle magazine. sample to see if the virus would grow. The mask-printing effort was Another team collected nasopha- launched after Shaffer, who was ryngeal swabs and blood samples helping to transport patients from from COVID-19 patients hospitalized hospitals in Gallup, found workers at UNMH to study their immune there wearing bandanas instead of responses. They categorized the sam- surgical masks and wrapping them- ples as severe or non-severe based on selves in plastic bags because they the patients’ symptoms and survival. lacked sufficient PPE to safely work Center for Global Health faculty Then, the samples were subjected around COVID patients. Shaffer’s also turned their attention to study- to next-generation sequencing to plea for help found its way to Salas, ing patterns of SARs-CoV-2 infection discover what gene networks differed who was ready with a technical under the guidance of director between the two categories. solution. Douglas J. Perkins, PhD. “Once you find emergent pathways The masks are made in four A team visited University of New that are good for discriminating color-coded sizes. Each 3D printer Mexico Hospital to look for fomites: between the groups, you go in and can create multiple masks at a time, something in the environment that look specifically at that pathway and an automated process that takes 12 to could carry infection. Team members all the genes in it,” Perkins explained. 14 hours. Afterwards, the volunteers swabbed surfaces around the hospital This helped researchers determine sand each mask down to remove that could be contaminated with the what drugs might block “severe dis- excess filament and package it for virus, including personal protective ease genes” and test how they work in shipping. equipment and the exposed skin of the severe patients’ blood cells. The soft plastic mask hugs the health care workers. Christina Salas, PhD, associate face, and a detachable cartridge holds In the lab, Perkins and his team professor in The University of New commercially available air condi- isolated RNA from the swabs to see if Mexico Department of Orthopaedics tioning filters capable of blocking any of it was from SARS-CoV-2. If they & Rehabilitation usually focuses on the passage of the coronavirus. The found viral RNA, the team exposed biomedical engineering problems, like masks can be wiped down with developing new joint replacements. alcohol or hydrogen peroxide – or But when the COVID-19 pandemic sterilized with ultraviolet light – and reached New Mexico, she and a team are reusable. of volunteers, engineering students Salas has made frequent trips to and research assistants manned Gallup hospitals and eastern Navajo 3D printers to produce thousands chapters to assess the need for of protective face masks and face PPE. “We bring along donations of food, water and diapers – you name it – anything someone might need a disaster relief situation.” █

10 unm health sciences center research annual report 2020 Domenici Hall Cerebral to Host Brain Injury Support and Substance Use Disorder Research

By Robert Oliver

he University of New Mexico interdisciplinary research into brain functional studies – and Health Sciences Center has substance use and brain injury. ultimately, human behavior itself. T received $4 million in funding Domenici Hall is already the site With this in mind, the grant task from the National Institutes of of ongoing brain-focused research. force sought to develop a facility Health to expand facilities at Pete Construction is estimated to be where all of these levels of research and Nancy Domenici Hall to support completed by Summer 2022, and could occur in the same space. “The Interdisciplinary Substance Use and although there may be delays due to ground floor focuses on preclinical Brain Injury research with state-of- the COVID-19 pandemic, the prospect work, while the second floor houses the-art equipment and laboratory of new research space has already clinical research and ‘big-data’ space. stimulated the development of new analyses,” Shuttleworth said. Executive Vice Chancellor Richard grant funding and novel research at “Having everyone in the same S. Larson, MD, PhD, in collaboration UNM HSC. building, and sharing common with Bill Shuttleworth, PhD, professor “Brain injury and substance use are resources increases efficiency, but and chair of Neurosciences, Brandi two research areas that are critical also provides the opportunity for Fink, PhD, associate professor in for New Mexico,” Shuttleworth said. ‘coffee pot’ talk between researchers the Department of Psychiatry & “This facility will be invaluable for in different neuroscience subfields,” Behavioral Sciences, and Ludmila bringing together the best talent in he said. A molecular neurobiologist Bakhireva, MD, PhD, MPH, professor the region, and create the critical mass and a clinical MRI researcher might in the College of Pharmacy, applied needed to tackle tough problems.” come up with an entirely new way for the Biomedical Research Facilities Neuroscience integrates ultrafine of solving a research question in the C06 matching funds grant to research at the cellular and molecular course of a short conversation in create a new core facility to further level, animal behavior, human-based between experiments.

unm health sciences center 2020 / scientific support 11 Brain injury and substance use are two research areas that are critical for New Mexico. Bill Shuttleworth, PhD

The new facility will also allow for environment to study the effect of center grant led by Shuttleworth to the seamless combination of research alcohol-related cues that could lead develop interventions for stroke and strategies at different levels for more to relapse. This facility will be used traumatic brain injury. holistic research projects, including in conjunction with a group therapy “The main point of the building “wet lab” molecular research spaces, center to develop better interventions is to provide nationally competitive animal behavioral facilities and novel to mitigate a patient’s propensity to resources to attract best researchers human-focused research laboratories relapse in response to these cues. regionally and increase the critical – some of the most state-of-the-art The bar laboratory might also be mass of investigators working on research spaces in the state, and used in conjunction with human these two topics (brain injury and possibly the Southwest. brain-imaging facilities to study how substance use) that are of such critical One human behavioral suite activity in specific brain regions shifts importance of communities around will be an “apartment” laboratory, in response to those cues. New Mexico,” Shuttleworth said. designed to mimic an everyday living The promise of this new facility “We want to create critical mass space. It will allow researchers to has already stimulated new collab- of the best and brightest in the study interpersonal relationships orations among UNM researchers. region working on these important between subjects performing every- Development of the new facility was problems,” he said. “Creating a state- day chores or cooking. also integral to recent renewal of of-the-art physical home is a big step An alcoholism-focused labo- the UNM Center for Brain Recovery forward, and we’re excited to get to ratory seeks to reconstruct a bar and Repair, an NIH-funded COBRE work.” █

12 unm health sciences center research annual report 2020 Major Milestone UNM to Launch New Alzheimer’s Disease Research Center

By Michael Haederle

he National Institute on Aging has awarded a three-year $3.1 million grant to establish an explor- atory Alzheimer’s Disease Research Center at The University of New Mexico that will provide Tcare and clinical investigation for residents with cognitive decline. The new center – one of four that are joining an existing network of 31 federally funded Alzheimer’s centers – will provide New Mexicans with access to the latest in clinical evaluation, treatment and research for the cognitive disorders that will afflict a growing number of people as the population ages. “Our exploratory center will prioritize American Indians and other rural and underserved popula- tions in New Mexico,” said Gary Rosenberg, MD, director of the UNM Center for Memory & Aging and the principal investigator on the new grant. “This will be one of the only Alzheimer’s centers in the Mountain West,” he added. “Except for one in Arizona, there are none in Colorado, Utah, Texas and the other states up to the Canadian border. This gives us unique opportunities to improve dementia care in New Mexico and surrounding states.” The new centers mark a strategic expansion into areas of the country that until now have been under-represented in Alzheimer’s research. The UNM group will provide an on-site cognitive assessment clinic and use a mobile magnetic resonance imaging scanner to incorporate cognitive and dementia care for Native Americans who reside in rural areas of New Mexico. The scanner is operated by the Mind Research Network, which shares quarters on the UNM Health Sciences campus with the Center for Memory & Aging. Once the COVID-19 threat subsides, the study will begin on New Mexico reservations and pueblos with the Mobile On-Site Screening and Testing program. The Center will also focus on co-morbid diseases in a partnership with several pueblos established by UNM scientist Vallabh “Raj” Shah, PhD. Shah has spent a quarter century working with Zuni Pueblo to help mitigate health effects of and kidney disease. He is joining in this new initiative, as these diseases are major contributors to cognitive decline and dementia. While UNM’s new exploratory center will enhance relationships between the School of Medicine and the state’s American Indian communities, it will also engage those with memory disorders throughout the state to participate in clinical care, treatments and research, Rosenberg said. Gary Rosenberg, MD The grant provides funding for three years to establish and enhance cognitive care and research programs at UNM, Rosenberg said. This will pave the way for a successful transition to a fully established Alzheimer’s Disease Research Center that will serve as a long-term resource for New Mexico. █

The new centers mark a strategic expansion into areas of the country that until now have been under-represented in Alzheimer’s research.

unm health sciences center 2020 / major milestone 13 Gauging the Risks UNM Metals Study Evaluates Toxic Exposures in Native American Communities

By Rebecca Sena

y some estimates, 600,000 Native Studies have primarily focused on about how Americans in the Southwest live uranium exposure, but it has become various Bwithin 10 kilometers of aban- apparent that “virtually every metal metals Johnnye Lewis, PhD doned hard rock or uranium mines, you can think of contaminates these interact in where they are exposed to metals in sites,” Lewis says. the process of DNA repair. the soil, air and water. The METALS center takes a multidis- Another major problem that Lewis The University of New Mexico ciplinary approach, with collaborations and her colleagues encounter with METALS Superfund Research occurring between UNM Main Campus metal exposure in the Native American Program Center, funded by a $1.3 and the Health Sciences Center. Main population is immune dysfunction. million grant from the National Campus experts are focusing on the “We started looking at the immune Institute of Environmental Health environmental aspects of the study, response, because clinicians saw a need Sciences, seeks to determine the toxic including the movement and transport to treat much more aggressively for effects of metal exposure in Native of mine waste, while HSC faculty are infectious disease,” Lewis says. American populations. focusing on the biology. “Inflammation produced by these metals METALS Center Director Johnnye One project looks at the toxic in various systems is one of the funda- Lewis, PhD, Research Professor in effects of metal exposure on a cellular mental problems that we are seeing.” the College of Pharmacy, explains level and has already unearthed some The production of cytokines, the how metal exposure affects these exciting discoveries. chemical messengers that mediate the communities. “Uranium and arsenic, both of immune response, are also believed to “Exposure during active mining which are in the waste we look at, contribute to the dysfunction. was shown to increase the risk and were found to inhibit the ability of the Lewis believes that the collaborative severity of kidney disease," she says. body to repair damage to DNA,” Lewis efforts and community involvement of "While community exposure, or the explains. Essentially, these metals can the METALS Center benefits everyone. exposure that occurs from waste that attach to pockets in DNA molecules “When you bring that many perspec- is left behind, increases the likelihood to prevent the binding of zinc, an tives in on it, it creates a synergy that of developing hypertension and other element critical for the function of a you do not get in an individual lab,” she chronic diseases, such as diabetes and DNA damage-repair protein. says. The ultimate goal of the METALS .” “The interesting thing about that project is not only to better understand Although some health impacts of finding was if you had a sufficient how exposure is occurring, but to metal exposure are well established, amount of zinc in the system, it reduce the risk of exposure and develop “it has not been as straightforward outcompetes the metals to restore an effective intervention. as we thought to figure out how the the function of the protein,” she says. “It’s not just about understanding exposures are happening,” Lewis says. Unfortunately, a large percentage of the our basic science mechanisms, but Laguna Pueblo and the Navajo com- Navajo community are zinc deficient, how we can use that knowledge to munities of Red Water Pond Road, which really “sets up the perfect storm,” reduce the risk that people are facing and Blue Gap/Tachee have partnered Lewis says. This work is still ongoing, to drive better cleanup, break exposure with UNM to gain more insight. and researchers continue to learn more and reduce effects.” █

14 unm health sciences center research annual report 2020 Diving Into the Data New College of Nursing Research Sheds Light on Health Policy

By Michael Haederle

ata-driven medical records health care as opposed to pediatric study the analysis that promises to health care,” she says. impact of Johnnye Lewis, PhD Dshed light on major health “We know that poor transitions COVID-19 LisaMarie Turk, MSN, BSN policy challenges underpins several are associated with frequent visits to outbreaks on new research initiatives launched emergency rooms and other forms hospital surge capacity. within The University of New Mexico of high-intensity care, because there Associate professor Mary Pat Couig, College of Nursing over the past year. is a known gap that occurs between PhD, MPH, RN, in partnership with Dean Christine Kasper, PhD, RN, pediatrics and adulthood.” Dean Kasper and Sandia researchers and doctoral student LisaMarie Turk, Turk says the study, which is Patrick Finley and Drew Levin, is MSN, RN, are collaborating on a collecting data from more than 700 applying modeling and advanced data study of de-identified medical records hospitals and health care facilities, has analytics to an electronic medical to characterize the transition to adult significant policy implications. “One records database to shed light on the health care for young people with of the known issues is the loss of the problem. special health care needs. The work is typical funding source or insurance, Focusing both on New Mexico and being supported by a subaward from because that changes oftentimes in the nation as a whole, the team seeks the UNM Clinical & Translational adulthood,” she says. “There is a varia- to identify the populations known to Science Center. tion in policy and clinical applications be at higher risk. Where is the nearest “It’s exciting because it’s a doctoral across the country.” access to health care and what is the student who got this award,” said Children with special health care capacity to provide those services? Patricia Watts-Kelley, PhD, FNP, needs, such as intellectual disabilities, Sandia scientists bring broad mod- who earlier this year was appointed neurodevelopmental issues, autism, eling and analytics expertise to the Associate Dean for Research and cerebral palsy, cancer, diabetes project, while Couig’s team is applying Scholarship for the College. “It’s really and sickle cell anemia, have better their extensive expertise in public a big deal, and it’s kudos to Dr. Kasper prospects than was once the case. health emergency preparedness. and to Lisa Marie.” “Given our advances in medical One outcome, they say, is to design Turk, who has a sibling living with treatment, children who typically quantitative data-driven risk predictors epilepsy, has a personal interest in didn’t live far into adulthood are now to better anticipate future hospital case- the question of how to help young living into adulthood,” Turk says, loads, outcome metrics and suggested people living with chronic conditions “but the clinical applications haven’t courses of treatment based on patient effectively transition to health care as caught up.” demographics and medical history. an adult. In a second study, the College This timely collaborative research “This study is aiming to char- of Nursing is partnering with agreement could also open the way acterize, model and simulate the Sandia National Laboratories for broader application of artificial transition of individuals, particularly in a Cooperative Research and intelligence, data analytics and mod- adolescents and emerging adults Development Agreement to use eling across a wide range of nursing, with medical burdens and health care cutting-edge artificial intelligence health care and public health issues in needs, and their transition to adult and machine-learning techniques to New Mexico. █

unm health sciences center 2020 / diving into the data 15 Storytelling Solution Developing Unique Interventions to Stem Teen Suicide in Rural Communities

By Rebecca Roybal Jones

or a year and a half, Shannon shared with local policymakers and health – Latino, Latina youth – (they) Sanchez-Youngman, PhD, their parents. Their goal was to create may be more likely to commit suicide Fworked with youth leaders in the a new community health agenda aimed compared to whites,” she says. “Some tight-knit community of San Miguel at tackling some of those issues, “rather of the explanation has to do with their County to learn about the stressors than just simply focusing on clinical position in society. And so the expec- they face and come up with interven- interventions,” Sanchez-Youngman tation is that these social determinants tions to prevent teen suicide among says. “And that’s not to say that clinical of health explain partly how people Latinos. interventions don’t matter.” experience mental health issues.” The result was a series of digital The new $146,000 grant from For example, she says, an immi- stories created by the youth leaders. the TREE Center and the National grant whose parents crossed over to Now, the research scientist with Institute of Minority Health and the United States from Mexico may UNM’s College of Population Health Health Disparities will allow her to worry about deportation, hostility in is working to expand the study to help teens share their perspectives the community and where the next include more young people in rural regarding stigma and build a youth paycheck is coming from. New Mexico. She collaborates with summit so they can work with local “Let’s compare it back to those lead- the Transdisciplinary Research, health workers, parents and elected ers,” Sanchez-Youngman says. “Those Equity and Engagement Center for officials to create new policy solutions youth were feeling a sense of stigma Advancing Behavioral Health (TREE). and community-level interventions to and marginalization by the pressure The research pilot aimed to tackle the issues. to be perfect, which is a very different uncover the causes of stigma related “These are kids that seemingly have process than maybe a kid whose mom to suicide, particularly around Latino perfect lives, right? They’re athletes, is hooked on opioids. And there’s populations and rural communities, they’re getting good grades,” Sanchez- shame associated with that. But this as well as to look beyond the usual Youngman says. “But underneath work is very much interested in how mental health services, Sanchez- it all, they really revealed a lot of those social conditions impact a sense Youngman says. inadvertent community pressure on of belonging, a sense of whether I can “Many teens really talked about them to succeed because they’re under succeed or not, which are different feeling isolated at times and pressured a spotlight in a rural town, and that’s mechanisms.” by social media to sort of be the model really important. The San Miguel County pilot study of perfect kids in the community,” she “This is really about rural youth and will expand to include more youths says. “But inside, they were facing a lot feeling like they were under a constant and other communities, so that par- of feelings of anxiety and pressure to microscope to sort of live out where ticipants can share their stories with get out of the community.” their parents failed, and also to make each other and work to propose ideas The pilot study brought together the community proud.” to community leaders on addressing youth leaders and members of the For teens who aren’t at the top their stressors. San Miguel Family and Community of their class, Sanchez-Youngman The work is mainly done by teens Health Council, which represents a expects to find different struggles for teens with professional support coalition of 17 organizations. involving marginalization. so that they’ll be able to reach out to The teen dialogues led to the cre- “When populations experience other kids. “The stories are what make ation of a set of digital stories that were inequities in health or disparities in a difference,” she says. █

16 unm health sciences center research annual report 2020 Double Honors Angela Wandinger-Ness Receives 2020 Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring

By Michael Haederle

he last out-of-town trip Angela difference in their lives. It’s deeply course of her 33-year career, having Wandinger-Ness, PhD, took meaningful.” personally mentored 74 students and Tbefore the COVID-19 lockdown Wandinger-Ness, who joined fellows in her laboratory. Her trainees, was to Seattle, where, on February 15, the UNM faculty in 1998, studies from five continents, bring their she received the 2020 Lifetime Mentor GTPases, a family of enzymes that diverse abilities, culture, educational Award from the American Association operate as molecular switches in opportunity, gender, race/ethnicity for the Advancement of Science (AAAS). many different cellular functions. She and socioeconomic backgrounds to Six months later, Wandinger-Ness, currently is looking for way to trans- solve complex problems. Her mentees a professor in The University of New late her work into potential therapies encompass more than 370 students, Mexico Department of Pathology for ovarian cancer. Her research postdoctoral fellows and junior who serves as associate director for has been funded by the National faculty. education, training and mentoring and Science Foundation, American Heart She was honored by being elected a the Victor and Ruby Hansen Surface Association, National Institutes of fellow of the AAAS, the world’s largest Endowed Professor in Cancer Cell Health, Department of Defense and scientific society, in 2012. Biology and Clinical Translation at the private foundations. “You become part of a network UNM Comprehensive Cancer Center, She has twice been singled out by of people who are like-minded, and received the 2020 Presidential Award her colleagues at the UNM Health therefore you can connect more for Excellence in Science, Mathematics Sciences Center for the annual broadly across the country and have and Engineering Mentoring. Excellence in Research Award and a bigger impact,” she said of her Wandinger-Ness was among 12 was nominated for the Presidential membership in the society. “You can researchers who were honored with award by Valerie Romero-Leggott, use that capital to help your trainees the award on August 3 – this time MD, the HSC’s vice chancellor for more, to connect more, to learn virtually – in an online ceremony Diversity, Equity and Inclusion. more and bring new things to your presided over by Robert Mayes, Wandinger-Ness has made work area.” █ program director for Excellence mentorship a centerpiece over the Awards in Science and Engineering at the National Science Foundation. The award, billed as “the Nation’s highest honors for mentors who work with underrepresented groups to develop fully the Nation’s human resources in STEM,” comes with a $10,000 honorarium. “It’s incredibly humbling to be the recipient of these really prestigious awards this year,” she said. “It’s really with the support of the trainees and mentees who feel you’ve made a

unm health sciences center 2020 / double honors 17 SOUND INVESTMENT UNM’s T32 Programs Provide Critical Support for Graduate Students and Postdoctoral Fellows

By Yamhilette Licon Muñoz

uth L. Kirschstein made history of Alcohol Abuse and Alcoholism CRTP currently funds six predoctoral as the first woman to direct (NIAAA) and the research focus and two postdoctoral trainees. one of the National Institutes includes different areas of alcohol The CRTP consists of 25 mentoring of Health. An active promoter neuroscience research, such as Fetal faculty from 12 basic science and Rof training programs to mentor Alcohol Spectrum disorders, alcohol clinical departments and/or colleges, underrepresented scientists, she craving, dependence, tolerance and including 15 professors, four associate knew the importance of investing in withdrawal, and the stress, hormonal professors and six assistant professors. scientists to ensure the advancement and cognitive effects of alcohol. The areas of research include vascular of knowledge. The award provides tuition, fees, biology, cardiovascular toxicology, cell The Ruth L. Kirschstein insurance and stipend support from signaling and clinical/translational Institutional National Research the NIH and NIAAA. In addition, science. Service Award – also known as the students receive funds for research “Our CRTP provides an integrative T32 award – is a major training supplies and travel expenses to scien- approach to understand the mech- program supported by the National tific meetings. “We help the students anisms of cardiovascular disease,” Institutes of Health (NIH). to network with other experts in the says Thomas Resta PhD, current The University of New Mexico field,” Valenzuela says. director of CRTP. “We have mentors Health Sciences Center currently The UNM Center for Infectious who work both in basic science and has three T32 training arms: The Disease and Immunity has devel- translational research.” Alcohol Research Training Program, oped the Infectious Disease & The quality and variety of mentors the Cardiovascular Research Training Inflammation Program (IDIP) T32 has contributed to the success of Program and the Infectious Disease & training grant. Under the direction of UNM’s T32 programs. To be funded, Inflammation Program. Michelle Ozbun PhD, this program NIH requires a strong group of All three are designed to support studies infectious and immunologi- the careers of graduate students and cally mediated diseases. postdoctoral fellows. IDIP accepts four predoctoral “The Alcohol Research Training students and two postdoctoral fellows Program in Neurosciences provides and pairs trainees with mentors. graduate students with multidis- Mentors are experts on the infectious ciplinary research training that diseases and immunity field at UNM, prepares them for a successful career the UNM School of Medicine and in alcohol research,” says training the Lovelace Respiratory Research program director C. Fernando Institute. Valenzuela MD, PhD. “Currently, we UNM’s Cardiovascular Research have four graduate students enrolled Training Program (CRTP) is funded in the program.” by a T32 grant from the National This program is funded by a T32 Heart, Lung, and Blood Institute. The grant from the National Institute

18 unm health sciences center research annual report 2020 To be funded, NIH requires a strong group of established scientists with high expertise on the field.

established scientists with high expertise on the field. The existence of the T32 grants has propelled the development of concentrations of coursework and journal clubs designed to ensure specialized training in the areas of cardiovascular physiology, infectious disease and inflammation and alcohol research. To be part of the program, NIH requires trainees to be U.S. citizens or permanent residents and to work with a mentor who is part of the T32 award. The trainees themselves are huge contributors to the T32 pro- gram’s success, measured in large part by how many go on to accomplished research careers. “We have improved the program over the years using the feedback from our students,” Valenzuela says. █

unm health sciences center 2020 / sound investment 19 the university of new mexico health sciences center Research 2020 Training Grants

Rosstin Ahmadian, MD/PhD Eduardo Anaya, PhD Elizabeth Bailey, PhD Candidate T32 Scholar, NIAID K12 Scholar, NIGMS T32 Scholar, NIH Infectious disease, cell signaling and biophysics Adapting single-particle techniques to Oxidant signaling in pulmonary hypertension Mentor: Aaron Neumann, PhD interrogate receptor signaling complexes, Mentor: Thomas Resta, PhD primarily with the B cell receptor Mentors; Diane Lidke, PhD; Keith Lidke, PhD

Victoria Balise, PhD Cindy K. Blair, PhD Eliseo Castillo, PhD K12 Scholar, NIGMS KO7 Scholar, NCI KL2 Scholar, NCATS Identifying how tetraspanins regulate Developing expertise in the design and Understanding the gut microenvironment, processes involved in hematopoietic stem and dissemination of home-based interventions that immune cells and microbiota in intestinal progenitor cells use a whole-of-day approach to physical activity health and inflammation Mentors: Jennifer Gillette, PhD; Alicia Bolt, PhD; in older cancer survivors. Mentors: Judy Cannon, PhD; Leah Freeman, PhD Mentors: Sally Davis, PhD; Vernon Shane Pankratz, Hengameh Raissy, PharmD PhD; Carla Herman, MD; Wendy Demark- Wahnfried, PhD; Anita Kinney, PhD

Laura Weise Cross, PhD Thomas De Pree, PhD Sharina Palencia Desai, PhD T32 Scholar, NIH K12 Scholar, NIGMS T32 Scholar, NIAID Oxidant signaling in pulmonary hypertension Understanding of the interdisciplinary T cell trafficking during ovarian cancer disease Mentor: Thomas Resta, PhD relationship between earth and planetary progression in the peritoneal tumor environment sciences, environmental health sciences and the Mentor: Sarah Adams, MD civil and environmental engineering employed at so-called ecological “sacrifice zones” in northwestern New Mexico Mentors: Debra MacKenzie, PhD; Johnnye Lewis, PhD; William Schaedla, PhD

20 unm health sciences center research annual report 2020 Tammi Duncan, PhD Daniel Falcón, PhD Máté Fischer, PhD Candidate K12 Scholar, NIGMS K12 Scholar, NIGMS T32 Scholar, NIAAA Demonstrating that arsenite induced an oxidative Regulatory T cell editing in response to PARP Stem cell culture, neurodevelopment, FASD stress and DNA damage response in human inhibition and CTLA4 immune checkpoint disease modeling, gene expression, cortical T-lymphocytes, while uranium had no effect blockade. patterning Mentors: Laurie Hudson, PhD; Mentors: Sarah Adams, MD; Judy Cannon, PhD; Mentor: Jason Weick, PhD Matthew Campen, PhD; Terri Koontz, MS

Muskan Floren, PhD Kathryn Frietze, PhD Selina Garcia, PhD Candidate F31 Fellow, NCI KL2 Scholar, NCATS F31 Fellow, NHLBI Identifying key regulators of chemotherapy Investigation of antibody responses to infectious Studying the role of the acid-sensing Io Channel 1 resistance in acute myeloid leukemia (AML) and diseases, developing vaccines against Chlamydia in the systemic vasculature developing therapies that are directed toward the trachomatis, Dengue virus and opioids Mentor: Nikki Jernigan, PhD AML cell population residing within the bone marrow Mentors: Bryce Chackerian, PhD; Mentor: Jennifer Gillette, PhD Thomas Byrd, PhD

Kymberly Gustus, PhD Candidate Julie In, PhD Elton Jhamba, PhD F31 Fellow, NIAAA K01 Scholar, NIDDK K12 Scholar, NIGMS Adult hippocampal neurogenesis as a therapeutic Mechanism of Wnt and Hedgehog signaling in Developing super-resolution microscopy tech- target in Fetal Alcohol Spectrum Disorder intestinal injury and regeneration; role of serine nologies to study protein-protein interactions on Mentor: Lee Anna Cunningham, PhD protease enterotoxins in watery diarrhea mast cell membranes in allergic responses, and the Mentors; Olga Kovbasnjuk, PhD; interplay of receptor tyrosine kinases on cancer cells Eric Prossnitz, PhD Mentors: Diane Lidke, PhD; Keith Lidke, PhD

Benjamin Lantz, PhD Candidate Christy Mancuso, PhD T32 Scholar, NIH K12 Scholar, NIGMS Pulmonary hypertension Elucidating how dietary and environmental Mentor: Laura Gonzalez Bosc, PhD markers can be used to learn more about an individual’s diet and movement/migration using stable isotope ratio biomarkers Mentors: Seth Newsome, PhD; Heather Edgar, PhD, William Schaedla, PhD

unm health sciences center 2020 / training grants 21 Perenkita Mendiola, PhD Candidate Emily Morin, PhD Bianca Myers, PhD Candidate T32 Scholar, NIH K12 Scholar, NIGMS T32 Scholar, NIAAA Identifying regulators of hydrogen sulfide produc- Investigating endothelial dysfunction and Studying the effect of adult alcohol consumption tion and signaling within vascular endothelium finding new drug delivery methods; cholesterol on the progression of glioblastoma multiforme Mentors: Nancy Kanagy, PhD, Laura Gonzalez regulation of vascular tone in hypertension Mentors: C. Fernando Valenzuela, MD, PhD; Bosc, PhD Mentor: Jay Naik, PhD Tou Yia Vue, PhD

Sarah Olguin, PhD Candidate Rob Oliver, PhD Erica Pascetti, PhD Candidate T32 Scholar, NIAAA T32 Scholar, NIH T32 Scholar, NIH Utilizing dura-resting EEG to evaluate prenatal KSRP-directed mechanisms of angiogenesis Hematopoietic stem and progenitor cells alcohol exposure during rodent touchscreen tasks in glioblastoma multiforme Mentor: Jennifer Gillette, PhD Mentor: Jonathan Brigman, PhD Mentor: Amy Gardiner, PhD

Gabriela Perales, PhD Candidate Dominique Perez, PhD Candidate Katelyn Reinhart, PhD T32 Scholar, NIH T32 Scholar, NIH T32 Scholar, NIH Studying angiogenic targets of miR-150-5p and Utility of small molecule inhibitors of cAMP Study of spreading depolarization (SD), and investigating the role of miR-150-5p in regulating efflux for translation as leukemia therapeutics the basic physiological mechanisms of SD that angiogenesis in the developing embryos both in Mentors: Larry Sklar, PhD; contribute to the progression of brain injuries, vitro and in vivo during prenatal alcohol exposure Alexandre Chigaev, PhD including stroke Mentor: Amy Gardiner, PhD Mentor: C. William Shuttleworth, PhD

Melanie Rivera, PhD Candidate Emmanuel Rosas, PhD Lilliana Sanchez, PhD Candidate F31 Scholar, NCI K12 Scholar, NIGMS T32 Scholar, NIAAA Investigating the role of Rac1 in ovarian cancer Investigating the role of G-protein coupled Studying moderate prenatal alcohol exposure metastasis in the peritoneal niche, including the estrogen receptor (GPER) in the development and its effects on the hippocampus, specifically role of immune modulation by a Rac1-targeting of anti-hormone resistance and whether novel in associational learning and memory drug or knockout therapeutic anti-hormone approaches that prevent Mentor: Benjamin Clark, PhD Mentor: Angela Wandinger-Ness, PhD cross-activation of GPER can reduce anti-hormone resistance in ERα-positive breast Mentor: Eric Prossnitz, PhD

22 unm health sciences center research annual report 2020 Raquela Thomas, PhD Leslie Toledo-Jacobo, PhD Nikole Warner, PhD K12 Scholar, NIGMS K12 Scholar, NIGMS T32 Scholar, NIAID Developing a clinically-relevant model for Studying the regulatory role of Myotonic Investigating the antibody response to chimeric tumors that will be utilized to investigate dystrophy-related CDC42-binding kinase proteins Dengue virus and using this knowledge to tumor editing in response to oncolytic virotherapy on migration, invasion and ultimately metastasis inform vaccine design Mentors: Eric Bartee, PhD; Allison Kell, PhD; of ovarian cancer cells Kathryn Frietze, PhD; Bryce Chackerian, PhD; Jennifer Curtiss, PhD Mentors: Angela Wandinger-Ness, PhD; Kathryn Hanley, PhD Laurie Hudson, PhD; Jessica Smith, MS

Jordan Weisend, PhD Candidate Lea Weston, PhD Xiang Xue, PhD T32 Scholar, NIH T32 Scholar, NIAID K01 Scholar, NIDDK Cell and molecular mechanisms of protection Investigating the relationship between Iron and GI diseases induced by spreading depolarizations occurring in neuroinflammation and tau pathology. Mentors: Eric Prossnitz, PhD; remaining viable brain tissues following stroke Determining the role of anti-inflammatory Olga Kovbasnjuk, PhD Mentor: C. William Shuttleworth, PhD cytokine IL-10 in tauopathies such as Alzheimer’s disease Mentor: Kiran Bhaskar, PhD

unm health sciences center 2020 / training grants 23 Excellence in Research Awards 2020 The University of New Mexico Health Sciences Center’s 12th Annual Research Day Awards Ceremony was held (via Zoom) on November 20, 2020. The event, hosted by Executive Vice Chancellor Richard S. Larson, MD, PhD, recognized six scientists who were nominated by their peers and selected for recognition by a faculty committee on the basis of their outstanding research contributions.

David Peabody, PhD (top) Matthew J. Campen, PhD, Kimberly Page, PhD, MPH Bryce Chackerian, PhD MSPH Internal Medicine Molecular Genetics & Pharmacy Population Science Microbiology Basic Science Kimberly Page Team Science (Joint Awardees) Matthew Campen has had a long David Peabody is internationally career in pop- and Bryce recognized for his ulation science Chackerian research into the research, with are the very harmful effects of an emphasis on embodiment of air pollutants in the epidemiology team science. the lungs, as well of viruses, Over the past 16 as the cardio- particularly HIV and hepatitis C years, Peabody, a vascular and neurovascular systems. virus (HCV) infections in high-risk microbiologist, He conducted pioneering work on and under-served populations. As a and Chackerian, the toxicity of combustion source tenured professor in the Division of a virologist and mixtures, such as diesel and gasoline Epidemiology, she has led some of immunologist, engine emissions, and has recently the most significant research on HCV have partnered expanded his research to address infection globally and recently com- to use virus-like fundamental questions of how lung pleted the only prospective cohort particles as a the responses lead to systemic vascular study in the U.S. of HCV in young basis for novel vaccines targeting injury. He has published more than adults who inject drugs. In 2014, Page chronic and infectious disease. 100 peer-reviewed articles in high-im- and colleagues published the first They have developed new vaccine pact journals and is director of a new study in the U.S. showing that opiate candidates against human papillo- $20 million Center of Biomedical agonist treatment reduced HCV mavirus, malaria, HIV, Chlamydia, Research Excellence grant focusing on incidence by 60% in young adult influenza and Neisseria. They have the role of metal elements in health injection drug users. Her expertise also developed novel vaccines for and biology. Campen also serves as and experience with HCV led to cardiovascular disease by targeting director of the KL2 Mentored Career successful funding as co-principal molecules that regulate triglycerides Development program in the UNM investigator on the only preventive and LDL cholesterol metabolism. Clinical & Translational Science HCV vaccine trial ever conducted. And, they have collaborated with Center. researchers throughout the Health Sciences Center and at other insti- tutions. They were jointly named as Innovation Fellows by STC.UNM in 2017 and were elected to the National Academy of Inventors in 2019.

24 unm health sciences center research annual report 2020 Steven B. Bradfute, PhD Hengameh H. Raissy, Rebecca S. Hartley, PhD Center for Global Health PharmD Cell Biology & Physiology Junior Faculty Pediatrics Scolarship of Teaching and When SARS- Clinical Science Learning CoV-2 came to UNM anatomy As vice chair New Mexico, students have for research in Steven Bradfute long benefited the Department was ready. from Rebecca of Pediatrics, An expert on Hartley’s Hengameh emerging viral enthusiasm and Raissy primarily pathogens, gift for teaching. focuses on including Ebolaviruses, hantavirus, Recently, she pharmacotherapy equine encephalitis viruses and Zika, has been developing, testing and for childhood asthma. She has Bradfute rapidly established methods evaluating methods to improve been the principal investigator for for studying the novel coronavirus in student success in the Phase I large network trials whose results the BSL-3 facility that he directs. This medical curriculum. In particular, have been published in The New has fostered multiple experimental she is gauging the effectiveness of an England Journal of Medicine, The approaches for addressing the chal- integrated curriculum on long-term Journal of the American Medical lenges of novel coronavirus, including retention of anatomical knowledge. Association and The Lancet. She has viral pathogenicity, viral replication, She has also lent her extensive exper- also participated in large multicenter drug-screening and methods to mea- tise in the scholarship of teaching asthma clinical trials, directs the sure neutralizing antibody titers in and learning to other clinician CTSC’s Trial Innovation Network both animal models and humans. His educators who wish to enhance the and is the author of more than 80 efforts resulted in several publications learning experience for their clinical peer-reviewed papers. Raissy has for which he is the senior author and mentees. Hartley has also developed also brought her expertise to bear in numerous grant submissions that numerous Team-Based Learning supporting pediatric and adult cystic are awaiting feedback. In addition, Application Cases in Anatomy and fibrosis studies at UNM and she Bradfute’s hantavirus research has led Embryology for the Phase I cur- conducted the first-in-human trial to the establishment of an “antibody riculum and contributed to a pilot to test the use of nebulized urea as a bank” that has the potential of saving project for the UNM HSC Office diagnostic tool for Pseudomonas in CF the lives of those newly infected. for Diversity called “Advancing patients. Institutional Mentoring Excellence.”

unm health sciences center 2020 / research awards 25 the university of new mexico health sciences center

Contracts and Grants Office of the Chancellor 27 Office of the Executive Vice Chancellor 27 2020 Center for Infectious Disease & Immunity 27 Memory & Aging Center 27 Office of the Vice Chancellor for Research 27 Animal Research Facility 27 Clinical & Translational Science Center 27 College of Nursing 28 College of Pharmacy 28 College of Population Health 29 School of Medicine 30 Anesthesiology & Critical Care Medicine 30 Biochemistry & Molecular Biology 30 Comprehensive Cancer Center 30 Cell Biology & Physiology 32 Dental Medicine 33 Dermatology 33 ECHO Institute 33 Emergency Medicine 34 Family & Community Medicine 35 Internal Medicine 36 Molecular Genetics & Microbiology 38 Neurology 39 Neurosciences 39 Neurosurgery 40 Obstetrics & Gynecology 41 Office of the Medical Investigator 41 Orthopaedics & Rehabilitation 41 Pathology 42 Pediatrics 43 Psychiatry & Behavioral Sciences 46 Radiology 47 Student Services 47 Surgery 47 UNM Hospital 48 UNM Medical Group, Inc. 48

26 unm health sciences center research annual report 2020 OFFICE OF THE CHANCELLOR Center for Infectious Disease Piloting Pacemaker v. Defibrillator Therapy - Continuation $18,810 Jill Klar & Immunity Truman Health Services Terry Wu Surojit Paul Provider Agreement - Evergreen - Advanced Technology International Los Alamos National Laboratory Continuation $25,000 Nanolipoprotein Particle-Based Subunit Los Alamos National Laboratory - Vaccine Against Pneumonic Tularemia - Contract # 567915 $20,680 Steven McLaughlin Non-Specific Supplement $965,462 State of New Mexico Animal Research Facility Emergency and Specialty Services $1,000,000 Advanced Technology International Richard Larson Nanolipoprotein Particle-Based Suzanne Popejoy New Mexico VA Health Care System Subunit Vaccine Against Pneumonic City of Albuquerque Veterinary Services for the N.M. Veterans Tularemia $500,000 Primary Care/MSW Services Program - Affairs Health Care System - Continuation $161,970 Los Alamos National Laboratory Continuation $30,475 Obtain Physiological Response Data From Peter Shin Bacterial Cultures $49,464 CLINICAL & TRANSLATIONAL Lovelace UNM Rehabilitation Services SCIENCE CENTER Professional Services $75,000 Memory & Aging Center Justin Baca Katherine Zychowski Bufford Gary Rosenberg Sensor-Kinesis Corporation STC@UNM National Institute of Neurological Development and Testing of Surface Lipase Inhibitors to Prevent Rancidity Disorders and Stroke Acoustic Wave Analytical System $150,179 in Expressed Human Milk During MRI and CSF Biomarkers of White Storage $25,000 Matter Injury in VCID $1,101,287 Sensor-Kinesis Corporation

COVID-19 Specific Supplement - SARS- OFFICE OF THE EXECUTIVE Woolsey Pharmaceuticals, Inc CoV2 - Development and Testing of Surface VICE CHANCELLOR Woolsey Pharmaceuticals, Inc. $25,000 Acoustic Wave Analytical System $49,993

Richard Larson OFFICE OF THE VICE CHANCELLOR Lee Brown National Institutes of Health FOR RESEARCH Ohio State University Biomedical Research Facility $4,000,000 The Impact of Low-Flow Nocturnal Oxygen Larissa Myaskovsky Therapy on Hospital Readmission/Mortality UNM Foundation Dialysis Clinic, Inc. in Patients With Heart Failure and Central Private Gifts for Research Improving Healthcare Outcomes Sleep Apnea: A Pragmatic Trial $65,128 (1st Qtr - FY20) $37,388 in American Indian and Hispanic Transplant Matthew Campen UNM Foundation Recipients Using Culturally Tailored Novel National Center for Advancing Private Gifts for Research Technology $316,776 Translational Sciences (2nd Qtr - FY20) $1,445,711 University of Pittsburgh UNM Clinical & Translational Science UNM Foundation Increasing Equity in Transplant Evaluation Center KL2 2020-2025 $394,876 Private Gifts for Research and Living Donor Kidney Transplantation - Kathryn Frietze (3rd Qtr - FY20) $99,842 Continuation $44,105 National Institutes of Health UNM Foundation University of Pittsburgh Bacteriophage Virus-Like Particle Vaccines Private Gifts for Research Cardiac Resynchronization in the Elderly: Against Dengue Virus Non-Structural (4th Qtr - FY20) $5,626,657 Protein 1 $189,375 Elizabeth Kocher Miners Colfax Medical Center Professional Services - Continuation $25,000 A. Robb McLean New Mexico Department of Health Locum Tenens Program DOH Physician, PA and NP Services $150,000 New Mexico Department of Health Physician, PA, and NP Services Project $20,000

unm health sciences center 2020 / contracts and grants 27 Michelle Harkins Eric Prossnitz UNM Hospital Leidos, Inc Virtici, LLC Professional Services $53,600 COVID-19: Adaptive COVID-19 ASCEND: Accelerating Solutions for Treatment Trial $120,000 Commercialization and Entrepreneurial Sharon Ruyak Development in the Mountain West Sigma Theta Tau Karen Hawley IDeA States $874,016 The Effect of Prenatal Opioid and Alcohol University of Utah Exposure on Key Human Placental Immune A Randomized Trial to Determine the Hengameh Raissy and Serotonin Factors Influenced by TLR4 Role of Valganciclovir for Asymptomatic University of Arkansas Signaling Pathways $10,000 Cytomegalovirus Infected Hearing Impaired Data Coordinating and Operations Center Infants (ValEAR) - Non-Specific for the IDeA States Pediatric Clinical Trials Katherine Zychowski Bufford Supplement $1,845 Network - VDORA - Continuation $115,746 National Institute of Environmental Health Sciences Richard Larson Sherry Weitzen Neurovascular Consequences of Inhaled National Center for Advancing Research Triangle Institute Uranium Mine-Site Dust Exposure - Translational Sciences ESC - ACT NOWS - Eat, Sleep, Continuation $249,000 UNM Clinical & Translational Science Console $267,814 Center UL1 2020-2025 $3,991,077 COLLEGE OF PHARMACY COLLEGE OF NURSING University of Nevada, Las Vegas Joe Anderson Institutional Development Award Mary Couig New Mexico Department of Health Program Infrastructure for Clinical and Sandia National Laboratories BAA/Heart Disease and Stroke Prevention Translational Research: COVID-19 Electronic Health Records $20,000 Program Health Systems Intervention BERD - Continuation $231,950 Project $80,000 University of Nevada, Las Vegas U.S. Department of Veterans Affairs VA Office of Nursing Services IPA $16,153 Ludmila Bakhireva Institutional Development Award Program National Institute on Alcohol Abuse and Infrastructure for Clinical and Translational Judy Liesveld Alcoholism Research: PDC - Continuation $148,582 HRSA/Bureau of Health Workforce ENRICH-2: Stress-Reactivity and Self- University of Nevada, Las Vegas Nurse Education, Practice, Quality and Regulation in Infants With Prenatal CTR-IN Round 7 Subaward - Retention/Veteran Nurses in Primary Alcohol Exposure $672,158 Care - Continuation $388,648 Pharmacogenetics to Improve Opioid National Institutes of Health Prescribing for Native Americans: HRSA/Bureau of Health Workforce 6/6 Planning for the HEALthy Early Pilot Study $65,580 COVID Nurse Education Practice Quality Development Study - Non-Specific University of Nevada, Las Vegas Retention/Veteran Nurses in Primary Supplement $271,231 CTR-IN Round 7 Subaward - a Mixed Care COVID $64,285 National Institutes of Health Methods Study of Methamphetamine HRSA/Bureau of Health Resources 6/6 Planning for the HEALthy Early Use in the Context of the Opioid Development Study $271,231 Epidemic $54,999 Development Nurse Faculty Loan Program $59,535 New Mexico Department of Health University of Nevada, Las Vegas Enhancing Pharmacy-Based Naloxone Institutional Development Award Program New Mexico Board of Nursing Distribution $60,000 Infrastructure for Clinical and Translational N.M. Board of Nursing-Chinle $17,956 Research: CEO - Continuation $17,347 Matthew Campen Janice Martin National Institutes of Health University of Nevada, Las Vegas City of Albuquerque New Mexico Center for Metals in Biology Institutional Development Award Program Geriatric Education and Health and Medicine $2,521,061 Infrastructure for Clinical and Translational Maintenance $67,000 Research: T&E - Continuation $13,859 Baylor College of Medicine Carolyn Montoya Notification of Access to Toxic Effects University of Utah HRSA/Bureau of Health Workforce of E-Cigs Following Transition From Opioid ECHO $154,986 Advanced Nursing Education Workforce Conventional Cigarettes - Alberta Kong Program - Continuation $636,762 Continuation $124,368 University of Arkansas National Institutes of Health DCOC Leadership Committee $45,997 Presbyterian Healthcare Services ANE-NPR Program $139,164 Inhalation of Contaminated Mine Waste University of Arkansas Dusts As a Route for Systemic Metal IAMHealthy Study - ISPCTN El Pueblo Health Services Toxicity $486,483 El Pueblo Health Services $69,510 Network $28,109 National Institute of Environmental Health Jessie Maxwell Mountain Spirit Integrative Medicine Sciences Research Triangle Institute Mountain Spirit $62,646 Mechanisms of Vascular Toxicity From WEANING - ACT NOWS $182,368 Inhaled Toxicants $335,592

28 unm health sciences center research annual report 2020 Biological Mimetics, Inc Stabilization of Inactivated Polio Vaccine Using Spray Drying $9,266 Melissa Roberts Analysis Group, Inc. Frequency and Cost of Moderate Exacerbations in Asthmatic Patients in the US $45,000 Sunovion Pharmaceuticals Inc. A Case-Control Analysis of the Prevalence of Frailty, Cognitive Impairment, and Limited Expiratory Airflow Among Elderly Persons With Chronic Obstructive Lung Disease $40,605 Melanie Dodd National Institutes of Health Jay Simon First Choice Community Healthcare P42ES025589 - SRP Administrative U.S. Department of Veterans Affairs Pharmacist Consultant Agreement - Supplement: Data Collaborations $568,136 Radiopharmaceutical Goods and Continuation $93,072 Services $150,560 U.S. Environmental Protection Agency Linda Felton Center for Native American Environmental Sandia National Laboratories U.S. Department of Veterans Affairs Health Equity Research $300,000 SNL Isotopes Request $1,750 Formulation and Batch Records for the VA Medical Center in Duke University Susan Smolinske Albuquerque, N.M. $48,222 Attentional Mechanisms Underlying New Mexico Department of Health Information Processing in a Sample COVID-19 Coronavirus All Hazards Line - Eunice Kennedy Shriver National Institute of Navajo Children $88,493 Non-Specific Supplement $158,387 of Child Health and Human Development Ke Jian (Jim) Liu Aqueous-Based Two-Step Spray Health Resources and Services Drying As a Taste-Masking Drug National Institutes of Health Administration Delivery Platform $189,375 Mutational Signatures of a Combined Poison Center Stabilization and Environmental Exposure: Arsenic and Enhancement Program $133,289 Donald Godwin Ultraviolet Radiation $523,581 Prime Therapeutics New Mexico Department of Health Pharmacy Participation Agreement - National Institutes of Health COVID-19 Coronavirus All Hazards Continuation $125,000 Arsenic, GATA-1, and Line $109,311 Hematotoxicity $340,875 Truman Health Services Health Resources and Services Pharmacy Consultant Services $50,000 National Institutes of Health Administration Arsenic, GATA-1, and Hematotoxicity - COVID CARES Funding for Poison Pamela Hall Admin Supplement $97,233 Centers $31,601 National Institute of Allergy and Infectious Diseases University of Louisville Denver Health and Hospital Authority Vaccine-Mediated Control of Bacterial Particulate Cr(VI) Toxicology in Human Researched Abuse, Diversion and Virulence Regulation and Infection - Lung Epithelial Cells and Fibroblasts $40,513 Addiction-Related Surveillance System Work Order #15 - Continuation $12,500 Continuation $431,724 Debra MacKenzie National Institute of Allergy and Infectious Duke University Denver Health and Hospital Authority Diseases Using Silicone Wristbands as Non-Invasive Researched Abuse, Diversion and Vaccine-Mediated Control of Bacterial Passive Environmental Monitors to Addiction-Related Surveillance System Virulence Regulation and Infection - Evaluate Seasonal and Within-Family Work Order #4 $500 Supplement $24,925 Correlation for Environmental Exposures. - Continuation $5,932 COLLEGE OF POPULATION Laurie Hudson HEALTH Pavan Muttil University of Oklahoma Targeting G-CSF Receptor and Tumor- Nob Hill Therapeutics, Inc. Lisa Cacari Stone Formulation and Preclinical Testing of Associated Neutrophils in Colon W.K. Kellogg Foundation High-Dose Inhaled Therapy Against Non- Cancer $12,852 Communities of Practice for Advancing Tuberculous Lung Infection $120,898 Health Equity-Linking Knowledge, Practice Johnnye Lewis & Policy $100,000 National Institute of Environmental Health Clariant Healthcare Packaging Sciences Role of Activated Carbon As an Odor New Mexico Department of Health UNM Metal Exposure Toxicity Assessment Adsorbent in Pharmaceutical Packaging New Mexico Maternal Child Health on Tribal Lands in the Southwest Superfund Applications $16,533 Epidemiology Practicum Project $35,000 Research Program $1,271,267

unm health sciences center 2019 / contracts and grants 29 Tracie Collins John Rask Xiang Xue National Heart, Lung, and Blood Institute Vanderbilt University Medical Center National Institute of Diabetes and Texting for Mobility in Overweight/ Simulation Multicenter Project $47,589 Digestive and Kidney Diseases Obese Adults With Peripheral Artery Targeting Mitochondrial Iron Metabolism Karin Westlund-High Disease $82,054 in Inflammatory Bowel Disease $158,882 National Institute of Dental and Murlynn Lee Craniofacial Research Comprehensive Cancer Center Gilead Sciences Scfv Antibody Therapy for Chronic Examining Sociocultural Influences, Trigeminal Neuropathic Pain $189,625 Sarah Adams Knowledge, and Acceptability of Biomedical National Cancer Institute HIV Prevention Methods: Native American Biochemistry & Molecular Biology Mechanisms of Selective Therapeutic Synergy of PARP-Inhibition and CTLA4 College Students $229,101 Natalie Adolphi Blockade Engaged by Interferon-Gamma Research Triangle Institute Laura Nervi in the Ovarian Tumor Microenvironment - RTI Forensic Imaging Workshop and East Central Ministries Continuation $348,832 Strategic Planning for One Hope Centro Documents $71,024 New Mexico Cancer Care Alliance De Vida $12,500 Meilian Liu Clinical Trial Phase 2 $116,680 Rebecca Rae American Heart Association Anav Tribal Health Clinic Quartz Valley Transcriptional Regulation of Thermogenic New Mexico Cancer Care Alliance Indian Reservation Program $64,226 Clinical Trial Phase 3 $112,840 QVIR Evaluation for Youth & Family Tree National Institute of Diabetes and New Mexico Cancer Care Alliance Project - Continuation $396,291 Digestive and Kidney Diseases Clinical Trial Phase 2 $109,640 The Role of Adiponectin in Regulating Santa Clara Pueblo Prajakta Adsul Kha’po Owingeh RezRIDERS Project - Type 2 Innate Lymphoid Cells and Browning of Fat - Supplement $60,595 New Mexico Department of Health Continuation $200,000 Cancer Prevention and Control Program for W.K. Kellogg Foundation Mark McCormick New Mexico $5,000 American Federation for Aging Research New Mexico Tribal Data Cecilia Arana Yi Champions $150,000 Measurement of the Conservation in Mammalian Cells of the Effects of New Mexico Cancer Care Alliance Francisco Soto Mas Lifespan- Extending TRNA Synthetase Clinical Trial Phase 2/3 $107,080 University of Texas Health Center at Tyler Inhibitors. $98,500 New Mexico Cancer Care Alliance Health, Safety and Psychosocial Organic Clinical Trial Phase 2 $106,440 Farming Survey $94,578 Summer Raines Hayek University of San Diego Eric Bartee Kristine Tollestrup MDH Communities UNM - Specific American Cancer Society Tulane University Supplement $5,000 Arming Oncolytic Myxoma Virus $506,739 ACA - Public Health Training Vallabh Shah Centers $34,440 National Cancer Institute National Institute of Diabetes and Treatment of Multiple Myeloma Using Nina Wallerstein Digestive and Kidney Diseases Oncolytic Myxoma Virus $346,556 Columbia University American Indian Chronic Renal Insufficiency An Experimental Investigation Into the Cohort Study - Continuation $680,520 National Institute of Allergy and Infectious Diseases Impact of Socioeconomic Context on National Institute of Diabetes and Biological Markers of Aging, Health Rationally Combining Oncolytic Virotherapy Digestive and Kidney Diseases and TIM3 Blockade $227,250 and Mortality $56,982 American Indian Chronic Renal Insufficiency AltaMed Health Services Corporation Cohort Study - Specific Jessica Belmonte HEAL Through PCOR $40,000 Supplement $378,748 New Mexico Cancer Care Alliance Clinical Trial Phase 3 $112,840 SCHOOL OF MEDICINE Patient-Centered Outcomes Research Institute New Mexico Cancer Care Alliance Home-Based Chronic Kidney Disease Clinical Trial Phase 2/3 $109,640 Anesthesiology & Critical Care Care in Native Americans of New Mexico - Medicine A Disruptive Innovation - Specific Marianne Berwick Supplement $199,999 National Cancer Institute Melinda King Integration of Clinical and Molecular Anesthesia Associates of New Mexico Patient-Centered Outcomes Research Biomarkers for Melanoma Survival $536,127 Pediatric Cardiac Anesthesia $25,000 Institute University of North Carolina Eugene Koshkin Home-Based Chronic Kidney Disease Care in Native Americans of New Mexico - Identification of Lethal Melanomas at the Boston Scientific Corporation A Disruptive Innovation - Time of Diagnosis (Resub) $63,483 UNM Pain Medicine Fellowship 19-20: Continuation $165,966 Boston Sci $10,000

30 unm health sciences center research annual report 2020 Cynthia Blair National Cancer Institute Improving Physical Functioning in Older Cancer Survivors Through Light-Intensity Physical Activity $154,573 Ursa Brown-Glaberman New Mexico Cancer Care Alliance Clinical Trial Phase 3 $109,640 New Mexico Cancer Care Alliance Clinical Trial Phase 3 $107,400 New Mexico Cancer Care Alliance Clinical Trial Phase 3 $106,680 New Mexico Cancer Care Alliance Clinical Trial Phase 2 $91,840 New Mexico Cancer Care Alliance NRG Oncology Vi Chiu Clinical Trial Phase 1b/2 $116,680 NRG Oncology Foundation: National New Mexico Cancer Care Alliance Clinical Trials Network and NCI Community Clinical Trial Phase 3 - Non-Specific New Mexico Cancer Care Alliance Oncology Research Program (Federal) - Supplement $400 Clinical Trial Phase 2 $103,880 Non-Specific Supplement $215,606 Linda Cook New Mexico Cancer Care Alliance New Mexico Cancer Care Alliance National Cancer Institute Clinical Trial Phase 3 $100,960 Clinical Trial Phase 3 $112,456 A Population-Based Study of Ketorolac New Mexico Cancer Care Alliance and Ovarian Cancer Survival $392,750 New Mexico Cancer Care Alliance Clinical Trial Phase 3 $95,040 Clinical Trial Phase 1 $107,360 Zoneddy Dayao Miria Kano New Mexico Department of Health New Mexico Cancer Care Alliance University of Texas MD Anderson Cancer Clinical Trial Phase 3 $93,640 Development and Delivery of Cancer Center Survivorship Cancer Plans $84,638 Curriculum Development for SGM Cancer- NRG Oncology New Mexico Department of Health MDACC $14,395 NRG Oncology Foundation: National Clinical Trials Network and NCI Community Development and Delivery of Cancer Peng Mao Survivorship Cancer Plans - Oncology Research Program (Non-Federal) - National Institute of Environmental Health Non-Specific Supplement $90,680 Continuation $35,000 Sciences New Mexico Department of Health TC-NER in the Repair and Mutagenesis of Scott Ness Development and Delivery of Cancer DNA Alkylation Damage $191,250 National Institutes of Health Survivorship Cancer Plans $28,941 Mutations and Target Genes in Adenoid Dario Marchetti Cystic Carcinoma $359,813 Matthew Fero National Cancer Institute New Mexico Cancer Care Alliance Mechanisms of Melanoma Brain Adenoid Cystic Carcinoma Research Clinical Trial Phase 2 $113,480 Metastasis by CTCs Isolated From Patients' Foundation Blood $324,705 Biomarker for ACC Outcome $82,706 Yan Guo Indiana University National Cancer Institute Novo Nordisk, Inc. The Role of LMO2 in the Pathogenesis Functional Characterization of Brain- Novo Nordisk Inc. RNA Service of T-Cell Leukemia $10,049 Colonizing Breast Cancer CTC Agreement $38,064 Subsets $306,904 Richard Harvey Itzhak Nir National Cancer Institute Jean McDougall New Mexico Cancer Care Alliance Integration of Gene Expression Patterns, Rutgers, The State University of New Clinical Trial Phase 3 $107,360 Fusions, Mutations, Cytogenetics and Other Jersey Comparative Effectiveness of Interventions to New Mexico Cancer Care Alliance Clinical Variables for Subtyping Leukemias Clinical Trial Phase 3 $109,640 and Targeting Therapies $154,500 Increase Guideline-Based Genetic Counseling in Ethnically and Geographically Diverse Eric Prossnitz Neda Hashemi Cancer Survivors $23,140 National Cancer Institute New Mexico Cancer Care Alliance G Protein-Coupled Estrogen Receptor and Clinical Trial Phase 3 $116,680 Shiraz Mishra National Cancer Institute Breast Carcinogenesis $343,324 New Mexico Cancer Care Alliance R25 C-STEPS $146,951 National Cancer Institute Clinical Trial Phase 1b/2 $116,680 Carolyn Muller Molecular Mechanisms and Applications of National Cancer Institute Novel ER/GPER-selective Ligands $310,400 NCORP $1,767,175

unm health sciences center 2020 / contracts and grants 31 Rita Serda New Mexico Department of Health National Cancer Institute National Science Foundation DOH BCC Surveillance & Cancer CCSG: Administrative Supplement to Pathogen Mimic Cancer Vaccines $50,000 Survivorship Care Plans Project $14,934 Strengthen NCI-Supported Community Outreach Capacity Through Community Larry Sklar New Mexico Department of Health Health Educators of the National Leidos, Inc DOH BCC Surveillance & Cancer Outreach Network $115,000 BASE Project/MGMT: NCI Experimental Surviviorship Care Plans Project $14,193 Therapeutics Chemical Biology National Cancer Institute Consortium $78,410 Cheryl Willman University of New Mexico Cancer Center National Cancer Institute Support Grant: Continuing Umbrella Alan Tomkinson University of New Mexico Cancer Center Research Experience $113,625 National Institute of General Medical Support Grant $2,246,011 Sciences Cowboys for Cancer Research Cellular Functions of Eukaryotic DNA National Cancer Institute Cowboys for Cancer Research $97,028 Ligases $369,502 Dissemination of a Colorectal Cancer Screening Program Across American Indian Brigham and Women's Hospital National Institute of Environmental Health Communities in Southern Plains & Southwest Biomarker, Imaging and Quality of Life Sciences United States $1,000,000 Studies Funding Program $78,784 Roles of Lig3 and XRCC1 Genes in Genome Stability $307,800 National Cancer Institute Oregon Health & Science University Colorectal Cancer Screening Program Across SWOG Network Group Operations Center Lovelace Respiratory Research Institute American Indian Communities $400,000 of the NCTN: S1318: a Phase 2 Study of DNA Repair Capacity Assays for Lung Blinatumomab (NSC-765986) and Disease Risk Assessment $74,567 National Cancer Institute POMP $54,173 COVID Development of Epitope-Targeted Lawrence Berkeley National Laboratory SARS-CoV-2 Vaccines $373,749 Emrullah Yilmaz Structural Cell Biology & Physiology of DNA New Mexico Cancer Care Alliance Repair Machines Project -YR4 $66,600 National Cancer Institute Clinical Trial Agreement-Phase 2 $38,466 CCSG: Administrative Supplement to Cosette Wheeler Strengthen the Research, Training and Cell Biology & Physiology Becton, Dickinson and Company Outreach Capacity of the Geographic BDS-USHPVPC $5,000,000 Management of Cancer Health Disparities Amy Gardiner Program $250,000 National Institute on Alcohol Abuse and Albuquerque Area Indian Health Alcoholism Board, Inc. Oncology Research Information Exchange The Role of Mir-150 in Regulating Characterizing Disparities and Elucidating Network Angiogenesis During Prenatal Alcohol Opportunities Across the Cervical Cancer Addressing Cancer Disparities and Exposure $179,906 Continuum Among Native American Facilitating ORIEN Precision Medicine in Women $75,750 Collaboration With American Indian Laura Gonzalez-Bosc Nations $250,000 Department of the Navy Charles Wiggins Biomarkers of Hypoxia Exposure $135,193 National Cancer Institute Children's Hospital of Philadelphia Surveillance Epidemiology and End Results Phase 3 Randomized Trial of Inotuzumab Helen Hathaway Program $2,522,771 Ozogamicin for Newly Diagnosed High-risk National Cancer Institute B-ALL; Risk-adapted Post-induction Therapy Is Tumor-Adjacent Histologically Normal National Cancer Institute for High-Risk B-ALL, Mixed Phenotype Tissue Primed for Tumorigenesis? SEER Patterns of Care 2019 $63,171 Acute Leukemia, and Disseminated Continuation $313,008 B-LLy (1732 Study) $115,708 Nikki Jernigan National Heart, Lung, and Blood Institute R01 Renewal Vascular Smooth Muscle Function in Pulmonary Hypertension - Continuation $378,750 National Heart, Lung, and Blood Institute The Role of the Acid-Sensing Ion Channel 1 in the Systemic Vasculature - Continuation $23,883 National Heart, Lung, and Blood Institute The Role of the Acid-Sensing Ion Channel 1 in the Systemic Vasculatur - Non-Specific Supplement $294

32 unm health sciences center research annual report 2020 Vijay Naik Centers for Disease Control and Prevention Armenia Ministry of Health Exhalix, LLC Building U.S. Public Health Service Clinical ECHO Partnership With the Global Fund Dynamic Breath Gas Sensor for Detection Opioid Response Capacity $490,000 for HCV-HIV Care in Armenia $134,802 of Pulmonary Edema $33,000 Health Resources and Services University of Maryland Thomas Resta Administration Project ECHO Immersion in National Institutes of Health COVID Ryan White HIV/AIDS Program AIDS Tanzania $128,725 Minority Institutional Research Training Education and Training Centers Program Program (T32) - Continuation $204,358 COVID-19 Response $400,000 Chronic Disease Foundation CLDF PEP Program $120,000 Dental Medicine Health Resources and Services Administration New Venture Fund Gary Cuttrell SC AETC End HIV Epidemic Specific ECHO/Co-Impact Partnership for HRSA/HIV-AIDS Bureau Supplement $395,061 Achieving Global Scale $100,000 Dental Partnership Program, HRSA Ryan White Part F - Continuation $225,128 Gilead Sciences Presbyterian Medical Services MCO Depression Quality Improvement New Mexico Department of Health Improving Hepatitis C Care in Rural Pilot $65,000 Basic Oral Health Services $106,334 and Underserved Appalachian Communities $300,000 Health Care Service Corporation New Mexico Department of Health MCO Depression Quality Improvement Basic Oral Health $83,259 New Mexico Department of Health Hepatitis and HIV Clinical Consultant Project Project $65,000 Dermatology - Continuation $300,000 Western Sky Community Care Emily Altman New Mexico Department of Health Western Sky MCO Depression ECHO $65,000 Principia Biopharma Inc. Opioid Rapid Response Team $250,317 PRN1008-012: A Phase 3 Randomized, JHPIEGO Corporation Double-Blind, Placebo-Controlled, U.S. Department of Agriculture JHPIEGO Healthcare Workforce - Multicenter Trial to Evaluate the Efficacy First Responder ECHO Program for Rural Continuation $50,000 and Safety of Oral BTK Inhibitor PRN1008 in EMS Providers $250,000 Moderate to Severe Pemphigus $275,490 JHPIEGO Corporation University of California, Davis JHPIEGO Healthcare Workforce $50,000 Lilly USA, LLC ECHO Support for Multinational Health Tanzania Health Promotion Support 14V-MC-JAIR: A Multicenter, Randomized, Education Networks in Africa and Southeast Leveraging the ECHO Model to Improve Lab Double-Blind, Placebo-Controlled Phase 3 Asia - Continuation $233,728 Study to Evaluate the Efficacy and Safety of Services in Tanzania $49,384 Baricitinib in Adult Patients With Severe or Northwest Portland Area Indian Health Stanford University Very Severe Alopecia Areata $200,000 Board Stanford University T1d Support and Indian Health Service TeleECHO Clinic Principia Biopharma Inc. Technical Assistance $43,379 Support - Continuation $225,000 PRN1008-012: A Phase 3 Randomized, University of California, Davis Double-Blind, Placebo-Controlled, New Mexico Department of Corrections ECHO Support for Multinational Health Multicenter Trial to Evaluate the Efficacy N.M. Department of Corrections Education Networks in Africa and and Safety of Oral BTK Inhibitor PRN1008 in Hepatitis C $190,644 Moderate to Severe Pemphigus - Southeast Asia $40,146 Non-Specific Supplement $450 Health Resources and Services New Mexico Department of Health Administration John Durkin TB Border Health 2019 $40,000 South Central AIDS Education and Training Lilly USA, LLC Clinical Study: Ixekizumab in the Treatment Center Program $183,763 New Mexico Corrections Department of Lichen Planus $211,492 Re-Entry ECHO Program: Supporting JHPIEGO Corporation PEP Graduates As Peer Support JHPIEGO Healthcare Workforce - ECHO Institute Workers $34,740 Supplement $180,000 Sanjeev Arora Health Research Inc. Defense Health Agency High Plains Regional Education ECHO Partnership for Quality Improvement Telementoring Services Defense Health Cooperative #3 Innovations in HIV Care - Agency $792,283 ECHO for Education: Graduates and Teacher Continuation $25,935 Pipeline $163,314 National Network of Public Health Institute CDC Foundation Safe Opioid Prescribing ECHO $750,000 University of Maryland, Baltimore County COVID-19: Advanced HIV Disease in Project ECHO Immersion and Follow-Up the Context of COVID-19 Virtual Bristol Myers Squibb, Inc. Foundation Training in Nigeria $150,000 Training Series $25,550 Leveraging the ECHO Model for International COVID-19 Response $500,000 New Mexico Department of Health N.M. Opioid Rapid Response Project $138,304

unm health sciences center 2020 / contracts and grants 33 Prevent Cancer Foundation AORTIC Conference $25,000

Four Seasons Four Seasons Palliative Care Grant $12,500

University of British Columbia Vancouver PEP Training $10,000 Emergency Medicine Danielle Albright New Mexico Crime Victims Reparation Commission Coordination of Domestic Violence Death Review $140,000 New Mexico Crime Victims Reparation Commission Sexual Assault & Persons With Department of the Air Force Taos County Disabilities $150,000 UNM Educational Service Agreement FY20 - Medical Directorship - Continuation $36,000 Non-Specific Supplement $43,200 Justin Baca Valencia Regional Emergency Abbott Point of Care Inc. City of Rio Rancho Communication Center CS-2016-0005 Clinical Evaluation of I-STAT Medical Director Services - Professional Services - Continuation $9,000 Continuation $37,200 Ctni Nxg Test to Aid in the Diagnosis of Jon Kenneth Femling Myocardial Infarction $490,410 Bernalillo County Light AI, Inc. Laura Banks Medical Directorship - Pilot Study of Strepic Device for the New Mexico Transportation Department Continuation $14,000 Diagnosis of Group a Streptococcal Pedestrian Safety Initiative $300,000 Pharyngitis - Specific Supplement $196,480 K&I Field Services New Mexico Department of Homeland Medical Direction and Care - Olive View Medical Center-UCLA Security & Energency Management Continuation $12,500 EMERGEncy IDnet: Emergency Department NMDHSEM Preparedness Sentinel Network for Surveillance of Emerging City of Rio Rancho Conference $82,320 Infections - Continuation $7,000 Professional Services - New Mexico Department of Health Continuation $10,500 Andrew Harrell Partners in Preparedness City of Albuquerque City of Rio Rancho Conference $69,614 Medical Director Services $55,760 Professional Services $7,500 Darren Braude New Mexico Department of Public City of Rio Rancho Department of the Air Force Safety/N.M. State Police Professional Services - Continuation $5,000 UNM Educational Service Agreement Medical Direction $50,000 FY20 $518,760 U.S. National Park Service Bernalillo County Sheriff's Department Zion National Park ALS Refresher $4,481 Department of the Air Force Professional Services Medical Director and UNM Educational Service Agreement FY20 - Village of Cuba SWAT Training - Continuation $20,000 Non-Specific Supplement $495,480 Medical Directorship - Continuation $4,100 Jonathan Marinaro City of Albuquerque Sandia Crest Marathon Kindred Hospital (Transitional Hospital Medical Directorship - Continuation $382,593 Medical Directorship - Continuation $1,550 Corp. of NM) Medical Director Services - Valencia County Cameron Crandall Continuation $25,000 Medical Directorship $137,232 McLean Hospital CTN-0099: Emergency Department- Aaron Reilly New Mexico Public Safety Department INitiated BupreNOrphine VAlidaTION High Altitude Athletics Club Professional Services TEMS $82,167 Network Trial $107,918 Medical Director $2,000 Sandoval County Joy Crook Trans-Pecos Ultra Medical Directorship - Continuation $54,000 New Mexico Department of Health Medical Directorship - Continuation $2,000 FY20 Statewide EMS $50,000 City of Albuquerque Robert Sapien Professional Services Agreement - Douglas Dixon HRSA/Maternal and Child Health Bureau Continuation $50,000 Taos County N.M. EMS for Children Program $130,000 Medical Directorship - Continuation $36,000 Nationwide Children's Hospital C-Spine $40,200

34 unm health sciences center research annual report 2020 University of Arizona Arthur Kaufman Laura Parajon EMSC: Pediatric Emergency Care Applied Bernalillo County New Mexico Department of Health Research Network - Continuation $12,688 Adverse Childhood Experiences - Residents to the Border $674,000 Continuation $998,928 Philip Seidenberg Tassy Parker Abbott Laboratories Inc. City of Albuquerque University of Colorado Denver Alinity I STAT Hstni Design Validation Intensive Case Management FY20 Collaborative Hubs to Reduce the Protocol $311,643 FY20 $562,500 Burden of Suicide Among American Indian & Alaska Native Youth $170,464 Brandon Warrick Presbyterian Healthcare Services U.S. Department of Justice FY20 Presbyterian Healthcare Contract Washington State University U.S. Attorney Expert Witness for Services $173,532 Native-Controlling Hypertension and Yazzie v. USA $12,166 Risks Through Technology - FY21 - New Mexico Department of Health Continuation $56,706 Chelsea White FY20 New Mexico Immunization Isleta Health Center Coalition $137,787 University of Colorado Health Sciences Professional Services $96,250 Center New Mexico Department of Health Center for American Indian and Alaska Pueblo of Laguna Fire Protection Program New Mexico Immunization Coalition - Native Health Disparities $29,682 Laguna Pueblo Medical Direction $80,000 Continuation - FY21 $100,000 David Rakel Ramah Navajo School Board, Inc, dba Pine Sarah Lathrop Presbyterian Medical Services Hill Health Center New Mexico Department of Health Professional Services - Continuation $28,800 Medical Directorship for Ramah Navajo N.M. Emerging Infections Program $490,780 School Board, Inc. Pine Hill, New Mexico First Choice Community Healthcare W/BAA - Continuation $45,000 New Mexico Department of Health Professional Services Agreement - FY20 N.M. Emerging Infections Program - Continuation $25,000 Pueblo of Acoma EMS Specific Supplement $21,100 Acoma Pueblo EMS Medical First Choice Community Healthcare Directorship $36,000 Orrin Myers Professional Services Agreement - U.S. National Park Service Continuation $25,000 Cibola County Statistical Analyses of Restoration Medical Directorship - Continuation $12,000 Monitoring Programs in the Jemez Robert Rhyne Mountains of Northern New Mexico - Kaiser Permanente Research Institute U.S. National Park Service Continuation - FY21 $19,668 Patient-Centered Team-Based Primary Care Medical Directorship El Malpais/ to Treat Opioid Use Disorder, Depression El Morro $4,500 Marnie Nixon and Other Conditions $853,534 Project Concern International - Jenna White PCIGlobal.org New Mexico Department of Health Pueblo of Jemez N.M. CoIIN - Non-Specific Academic Detailing Project FY20 $114,468 Pueblo of Jemez Medical Direction Supplement $5,000 2020 $20,000 Valerie Romero-Leggott Janet Page-Reeves HRSA/Bureau of Health Workforce Town of Cochiti Lake National Institute on Minority Health and National HCOP Academies $644,491 Medical Director Services - Health Disparities Continuation $7,500 TERTULIAS: Addressing Social Isolation to Helene B Silverblatt Reduce Depression Among Female Mexican HRSA/Bureau of Health Workforce Village of Tijeras Area Health Education Centers Medical Directorship - Continuation $3,600 Immigrants $578,397 Program $407,820 Family & Community Medicine National Institute on Minority Health and Health Disparities Southwest Center for Health Innovation Antoinette Benton TERTULIAS: Addressing Social Isolation Contract for Services $5,000 New Mexico Department of Health to Reduce Depression Among Female Andrew Sussman FY20 Transdisciplinary Evaluation and Mexican Immigrants - Continuation - National Institutes of Health Support Clinic W/BAA $1,176,120 FY21 $522,134 Women in Survivorship Healthcare: Falling Colors Corporation EleValle Implementation of a Nurse Navigation Pre-Administration Screening and Resident EleValle Evaluation Services $3,550 Model for Medically Underserved Breast Review - FY21 - Continuation $194,569 and Gynecologic Cancer Survivors Using Nancy Pandhi Project ECHO $164,756 Valerie Carrejo Oregon Health & Science University Daniel Waldman American Academy of Addiction Psychiatry FY20 Oregon Clinical and Translational HRSA/Bureau of Health Workforce Minority Fellowship Program $29,681 Research Institute: Experiences With Residency Training in Primary Care Pediatric Cancer $15,659 Program $477,425

unm health sciences center 2020 / contracts and grants 35 Internal Medicine Osman Dokmeci HRSA/Office of Rural Health Policy AbbVie Radiation Exposure Screening Education Allen Adolphe M18-891: A Phase 3 Randomized, Placebo- Program $243,923 Gilead Sciences Controlled, Double-Blind Study to Evaluate Clinical Trial Phase 3: Upadacitinib in Adolescent and Adult HRSA/Office of Rural Health Policy GS-US-223-1017 $1,342,675 Subjects With Moderate to Severe Atopic Radiation Exposure Screening and Education Program $223,956 Sanofi US Services, Inc. Dermatitis - Specific Supplement $434,128 SAR439954: A Randomized, Double- AbbVie HRSA/Office of Rural Health Policy Blind, Placebo-Controlled, Parallel-Group, M18-891: A Phase 3 Randomized, Placebo- Radiation Exposure Screening Education Multicenter Study to Evaluate the Effects controlled, Double-Blind Study to Evaluate Program $37,810 of SOtagLiflozin on Clinical Outcomes in Upadacitinib in Adolescent and Adult Olga Kovbasnjuk Hemodynamically STable Patients With Subjects With Moderate to Severe Atopic University of Maryland, Baltimore County Type 2 Diabetes POST Worsening Dermatitis - Specific Supplement $160,728 Pathogenesis of E. coli and Shigella Heart Failure $833,242 AstraZeneca Pharmaceuticals, LP Infections in Human Enteroid Models - Christos Argyropoulos D3253c00001: A Study to Evaluate the Cont Y3 $204,139 Dialysis Clinic, Inc. Efficacy and Safety of Benralizumab Baylor College of Medicine CE-IT-IS COMPLEX $673,849 Compared to Mepolizumab in the Treatment Mediators of Intestinal Barrier Dysfunction Dialysis Clinic, Inc. of Eosinophilic Granulomatosis in Polyangiitis in Inflammatory Bowel Disease $94,688 COMPASS - Continuation $665,844 in Patients Receiving Standard-of-Care Treatment $25,600 University of Washington Dialysis Clinic, Inc. A Microphysiological System for Kidney Grand Rounds Support - Michelle Harkins Disease Modeling and Drug Efficacy Continuation $179,250 Cystic Fibrosis Foundation Testing $34,845 Cystic Fibrosis Care Center Program Soraya Arzhan 2019-20 $62,650 Christophe Lambert Dialysis Clinic, Inc. National Institutes of Health Implications of Hypernatremia in Hospitalized Michelle Iandiorio Deriving High-Quality Evidence From Patients Without and With Chronic Health Resources and Services National Healthcare Databases to Improve Kidney Disease $329,458 Administration Suicidality Detection and Treatment Comprehensive HIV Early Intervention Outcomes in PTSD and TBI $776,198 Cristian Bologa Services (Ryan White Part C) - Givaudan Flavors Corporation Non-Specific Supplement $538,921 Erin Madden Givaudan Flavors Y12 $205,000 Utah State University New Mexico Department of Health Tribal and Rural Opioid Initiative Integrated Steven Bradfute DOH HIV Provider Agreement W/BAA - Response Effort $19,464 U.S. Department of Defense Health Specific Supplement $348,046 Program Utah State University Effects of Passive Immunization on Health Resources and Services Translating Effective Opioid Harm Reduction Immunogenicity of Filovirus Administration and Wellness Training to Tribal and Rural Vaccines $1,201,171 Comprehensive HIV Early Intervention Utah Y2 $18,924 Services (Ryan White Part C) - Albert Einstein College of Medicine Continuation Y20-21 $179,640 A. Robb McLean Prometheus: A Platform for Rapid The Bell Group, Inc. Development of Immunotherapeutics and HRSA/HIV-AIDS Bureau Professional Services: UNM Center for Life - Immunoprophylactics Against Emerging COVID Ryan White HIV/AIDS Continuation $25,000 Viral Threats - Y2 $315,758 Program Part C EIS COVID $106,481 Lana Melendres-Groves Los Alamos National Laboratory HRSA/HIV-AIDS Bureau Complexa Immunogenicity of Delayed Antigen COVID Ryan White HIV/AIDS PRIMEx Plus CXA-10-2302 $114,944 Release Systems $60,000 Program Part D WICY COVID $36,185 United Therapeutics Corporation Celdara Medical, LLC Julie In TDE-PH-402: EXPEDITE: A 24-Week Blood Samples for Antibody Generation National Institute of Diabetes and Multicenter, Open-Label, Rapid Dose Against Hantaviruses $8,000 Digestive and Kidney Diseases Escalation Study in Remodulin Followed by Human Enteroids As a Model of Optimal Orenitram Dose in Subjects With Cleanbox Technologies Host-EHEC Interactions - Y6 $152,388 Pulmonary Arterial Hypertension $108,800 Bradfute Cleanbox PSA $7,500 Denece Kesler Pharmaceutical Research Assoc. Mark Burge HRSA/Bureau of Health Workforce Protocol AC-055-510: U.S.-Based, Novo Nordisk, Inc. Preventive Medicine Residency Observational, Drug Registry of Opsumit NN9535-4352: Long-Term Effects of Program $399,984 (Macitentan) New Users in Clinical Practice - Semaglutide on Diabetic Retinopathy in Non-Specific Supplement $101,013 Subjects With Type 2 Diabetes (FOCUS) Trial Phase 3b $263,537

36 unm health sciences center research annual report 2020 Liquidia Technologies Douglas Perkins Case Western Reserve University Protocol LTI-302: A Global Open-Label National Institute of Allergy and Infectious Effects of Biomedical Risk Factors on Neuro- Extension Study for Participants in LIQ861 Diseases Cognition Using MRI: Long Term Follow-up Trials to Evaluate the Long-Term Safety of Defining the Inflammation and Immunity of the Diabetes Control & Complications Inhaled LIQ861(Treprostinil) in Pulmonary Transcriptome in Severe Malarial Anemia for Trial/Epidemiology of Diabetes Interventions Arterial Hypertension (WHO Group 1) Immunotherapeutic Discovery $711,525 & Complications Study Phase IV - Specific Patients $60,160 Supplement $1,670 John E. Fogarty International Center for United Therapeutics Corporation Advanced Study in the Health Sciences University of South Florida ADAPT TDE-PH-401 $52,800 Training and Research on Severe Malarial Type I Diabetes Trialnet - Continuation Anemia - Yr18 $267,824 FY19-20 $390 Tudor Oprea National Institutes of Health Harvard School of Public Health Melissa Schiff Knowledge Management Center for Fogarty Global Health Training Fellowship New Mexico Department of Health Illuminating the Druggable Genome - Program - Y3 $24,920 CDC Maternal Mortality Review Committee Continuation $1,000,000 Grant - Continuation $85,102 David Schade New Mexico Department of Health The Jackson Laboratory George Washington University CDC Maternal Mortality Review Committee Illuminating the Druggable Genome by Glycemia Reduction Approaches in Grant $30,256 Knowledge Graphs $118,604 Diabetes: A Comparative Effectiveness East Carolina University, Brody School of Study - Y8 $650,876 Rahul Shekhar Karyopharm Therapeutics Inc. Medicine National Institute of Diabetes and COVID: XPORT-CoV-1001 $192,000 Ligand Specificity in Human Glucose Digestive and Kidney Diseases Transporters GLUT1-5 and GLUT9 - Diabetes Prevention Program - Phase 3 - Mark Sheldon Y2 - Amendment 1 $67,899 Continuation Y27 $263,486 U.S. Department of Veterans Affairs Kimberly Page Case Western Reserve University Interventional Cardiology Services at National Institute on Drug Abuse Epidemiology of Diabetes Intervention and the VA - Continuation $430,857 New Mexico Clinical Trials Node: Clinical Complications $126,549 Research and Practice to Address Substance Rutgers, The State University of New Use in Diverse, Rural and Underserved Case Western Reserve University Jersey Populations - Y2 $2,679,320 Epidemiology of Diabetes Intervention Myocardial Ischemia and Transfusion - and Complications - Specific CCC - Continuation Y3 $42,000 The RAND Corporation Supplement A1 $29,766 Improving Access and Treatment for Co- Manoocher Soleimani Occurring Opioid Use Disorders and Mental George Washington University U.S. Department of Veterans Affairs Illness Disorders $627,305 GRADE Sub-Study: Emotional Distress in a IPA - Barone $38,431 Comparative Effectiveness Trial of Diabetes U.S. Department of Veterans Affairs Upstate Affiliate Organization Treatments $13,912 Patient-Centered Models of Hepatitis C IPA - Zahedi $38,431 Care for People Who Inject Drugs - Continuation Y5 $429,986 Gulshan Parasher AbbVie M14-234 $1,482,617 AbbVie M14-675: A Multicenter Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Ulcerative Colitis $1,243,418 AbbVie M14-533: A Phase 3 Multicenter, Long- Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis $880,344 AbbVie M15-722: Efficacy and Safety of ABBV-323 in Subjects With Moderate to Severe Ulcerative Colitis Who Failed Prior Therapy $370,734

unm health sciences center 2020 / contracts and grants 37 Akshay Sood National Institutes of Health Effectiveness of Innovative Research Mentor Interventions Among Underrepresented Minority Faculty in the Southwest - FY 20-21 $742,896 Miners Colfax Medical Center Medical Consultation and Care $198,964 Miners Colfax Medical Center An Innovative Approach to Increasing Access to Miners in the Mountain West - Continuation Y2 $21,730 Mark Unruh Dialysis Clinic, Inc. DCI Supplemental Funding for American Indian Chronic Renal Insufficiency Cohort Study $1,191,304 Albuquerque Area Indian Health Service Nephrology and Rheumatology IHS Specialty Molecular Genetics & National Institutes of Health Services - Continuation $232,339 Microbiology A Nanoparticle-Based Vaccine Targeting PCSK9 - Non-Specific Supplement $25,657 University of Pittsburgh Kiran Bhaskar Technology-Assisted Stepped Collaborative National Institutes of Health Vojo Deretic Care Intervention to Improve Patient- The Role of Signaling in National Institute of General Medical Centered Outcomes in Hemodialysis Tauopathies - Continuation $2,227,795 Sciences Patients $214,333 , Inflammation and Metabolism National Institutes of Health in Disease Center $2,174,751 University of Washington The Role of Inflammasome Signaling in Treatment Options for Insomnia for Tauopathies $518,023 National Institutes of Health ESRD - Continuation $140,634 Autophagy Against Electro Cellular Health Solutions, LLC and HIV $744,529 Dialysis Clinic, Inc. Determine Anti-Inflammatory and Trophic SLEEP-HD DCI Supplement $97,047 Properties of Three Different Pulsed National Institute of Allergy and Infectious Electromagnetic Field Stimulation $34,356 Diseases Albuquerque Area Indian Health Service Pattern Recognition Receptors and Rheumatology IHS Specialty Services - Judy Cannon Autophagy in Mtb Control in AIDS $488,425 Continuation $90,240 Tau Technologies Interacting Swarms of Agents: From Alison Kell Albuquerque Area Indian Health Service Immunology to Social Media - National Institute of Allergy and Infectious Nephrology and Rheumatology IHS Continuation $215,456 Diseases Specialty Services $47,656 Mechanisms of Intrinsic Host Responses Bryce Chackerian to Hantavirus Infection $153,120 University of Washington National Institutes of Health Randomized ESRD Trial COmparing CBT A Nanoparticle-Based Vaccine Targeting Michael Mandell Alone VERsus With Buprenorphine $27,881 PCSK9 $487,466 National Institute of Allergy and Infectious Diseases Honeywell Aerospace Henry M. Jackson Foundation Prevention of HIV-Induced T Cell Killing Professional Services $25,000 Epitope-Based Vaccines for Neisseria by Autophagy $189,375 Lovelace Respiratory Research Institute Gonorrhoeae - Yr 2 $261,981 Mary Ann Osley Occupational and Environmental Health Massachusetts General Hospital National Institute on Aging Clinical Services - Continuation $25,000 Innate-Like BCR Activity As a Template for Functional Analysis of Cellular Zenith American Solutions, Inc. Universal Vaccination Against Influenza Quescence $310,575 Professional Services - Virus - Continuation $157,049 Michelle Ozbun Continuation $25,000 Massachusetts General Hospital National Cancer Institute

CDRH3-Independent B Cell Stimulation to Mechanisms of Infection by Oncogenic Selectively Expand VRC01 Lineages From a HPVs - Continuation Yr 4 $345,887 Fully Humanized Immunoglobulin Repertoire - Continuation $80,457 National Institutes of Health Sex-Based Differences in Oral HPV Henry M. Jackson Foundation Infections and Outcomes - Yr 2 $189,375 ACC STI CRC UNM Subcontract $63,785

38 unm health sciences center research annual report 2020 City of Albuquerque University of Rochester Biogen, Inc. Detection of EEHV in Albuquerque Support FOR-DMD Project, Part I CHARM TRIAL - 252LH301 $25,600 Biopark Elephants $154,080 AWD00001193 (Industry) - Jennifer Vickers Continuation FY19 $4,134 National Cancer Institute New Mexico Department of Health EGFR Signaling As the Nexus for HPV University of Rochester CMS Outreach Clinics - Neurology - Oncogene Regulation $40,659 Support FOR-MD Project, Part I Continuation FY20 $598,185 AWD00001193 (Industry) - Yi Yang Xuexian Yang Continuation FY20 $4,134 National Institutes of Health National Institute of Neurological The Cytokine Signal Suppressor CIS in Tobias Kulik Disorders and Stroke Giant Cell Pneumonitis $378,750 University of Cincinnati R01: Sphingosine 1 Phosphate Signaling in Multi-Arm Optimization of Stroke Cerebral Small Vessel Disease $2,640,472 National Institutes of Health Thrombolysis Stroke Trial - Non-Specific Atif Zafar Leptin Promotes Allergic Asthma Through Supplement $232,876 Unfolded Protein Responses $227,250 University of Cincinnati University of Cincinnati Atrial Cardiopathy and Antithrombotic Drugs Neurology StATins Use in Intracerebral Hemorrhage in Prevention After Cryptogenic Stroke - Corey Ford Patients $108,630 Non-Specific Supplement $63,066 Genentech, Inc. Bard Medical Division Neurosciences WA40404: A Phase 3b Multicenter BMD-1111: Impact of Fever Prevention Randomized, Double Blind, Placebo- in Brain Injured Patients $74,560 Andrea Allan Controlled Study to Evaluate the Efficacy National Institute of Environmental Health and Safety of OCRELIZUMAB in Adults University of Cincinnati Sciences With Primary Progressive Multiple Multi-Arm Optimization of Stroke Prenatal Arsenic Exposure Alters Sclerosis $1,457,054 Thrombolysis Stroke Trial - Transcriptional, Post-Transcriptional and Continuation $58,219 Post-Translational Programming $335,363 Genzyme Corporation Clinical Trial Agreement - Phase 4 $54,799 John Phillips Jonathan Brigman The Mind Research Network National Institute on Alcohol Abuse and TG Therapeutics MRN Medical Director - Alcoholism TG1101-RMS303: An Open-Label Extension Continuation FY20 $34,217 Prenatal Alcohol Exposure and Corticostriatal Study of Ublituximab in Subjects With Control of Behavioral Flexibility - Relapsing Multiple Sclerosis $52,244 Sarah Pirio Richardson Continuation $335,439 Emory University Biogen Idec Delineation of Individual and Temporal University of California, San Diego Observational Study Agreement - Phase 4 - Variations to Botulinum Toxin Neurophysiological Biomarkers of Behavioral Non-Specific Supplement $1,670 Treatment $155,533 Dimensions - Continuation $154,082 Tarun Girotra Ranjana Poddar National Institute of Mental Health University of Cincinnati National Institute of Neurological Psychiatric Disease-Associated CircRNA Anticoagulation in Intracerebral Hemorrhage Disorders and Stroke Modulates Synaptic Efficacy and Cortical Survivors for Stroke Prevention and Molecular Basis of Hyperhomocysteinemia- Function. $37,566 Recovery Trial $669,930 Induced Brain Injury in Ischemic Kevin Caldwell University of Cincinnati Stroke $592,165 National Institute on Alcohol Abuse and ARCADIA Cognition and Silent Stefan Posse Alcoholism Infarcts $142,000 National Institutes of Health Sex-Dependent Effects of Prenatal Alcohol University of Cincinnati Concurrent High-Speed fMRI and MRSI Exposure on Developmental Programming - Atrial Cardiopathy and Antithrombotic Drugs (R21) - Continuation FY21 $48,702 Continuation $335,523 in Prevention After Cryptogenic Stroke - Michel Torbey Lee Anna Cunningham Continuation-FY20 $30,243 Biogen, Inc. National Institute on Alcohol Abuse and Monika Krzesniak-Swinarska CHARM TRIAL - 252LH301 - Non-Specific Alcoholism University of Rochester Supplement $259,420 Connectivity of Adult-Generated Dentate FOR-DMD: Double-Blind Randomized Trial Granule Cells in a Mouse Model of University of California, San Francisco Prenatal Alcohol Exposure $45,016 to Optimize Steroid Regimen in Duchenne Brain Vascular Malformation Consortium: MD AWD00001200 - Predictors of Clinical Course $204,525 David Linsenbardt Continuation FY20 $18,180 National Institute on Alcohol Abuse and University of Chicago Muscular Dystrophy Association Alcoholism Trial Readiness in Cavernous Angiomas Repeated Binge Drinking and the UNM MDA and MDA/ALS Care Centers With Symptomatic Hemorrhage - W/BAA - June 2020 $10,000 Genetic Regulation of Corticostriatal Continuation 2020 $38,000 Synchrony $249,000

unm health sciences center 2020 / contracts and grants 39 Nikolaos Mellios Daniel Savage National Institute on Alcohol Abuse National Institutes of Health National Institute on Alcohol Abuse and and Alcoholism Role of Psychiatric Disease-Associated Alcoholism Alcohol Research Training in Circular RNAs in Neuronal Function and Fetal Ethanol-Induced Behavioral Deficits: Neurosciences $150,713 Cognition - Continuation $370,510 Mechanisms, Diagnoses and Intervention Competing Renewal $1,508,352 Jason Weick Johns Hopkins University Clemson University Placental-Mediated Mechanisms of Perinatal National Institute on Alcohol Abuse and RII Track-2 FEC: The Creation of Next- Brain Injury - Continuation $4,874 Alcoholism Generation Tools for Neuroscience $143,487 Fetal Ethanol-Induced Behavioral Erin Milligan Deficits: Mechanisms, Diagnoses and National Institute of Neurological National Institute on Alcohol Abuse and Intervention Competing Renewal - Disorders and Stroke Alcoholism Continuation $1,495,477 Directing Corticospinal Motor Neurons Prenatal Alcohol Exposure Potentiates Pain for Cell Replacement in Stroke - Via Lifelong Spinal-Immune Changes - Bill Shuttleworth Continuation $50,016 Continuation $290,039 National Institute of General Medical Sciences Tou Yia Vue Nora Perrone-Bizzozero UNM CBRR - Continuation Yr 5 $2,097,553 National Institute of Neurological University of South Carolina Disorders and Stroke Antagonistic Roles of Hud and KSRP for National Institute of Neurological Underlying Molecular Mechanisms of MRN Stability in Neuronal Growth $222,918 Disorders and Stroke Gliogenesis and Gliomagenesis in the Spreading Depolarizations and Neuronal CNS - Continuation $240,594 Arizona State University Vulnerability $293,975 Role of Circhomer1 in Synaptic Plasticity Neurosurgery and Cocaine-Seeking Behavior $161,058 New Mexico State University New Mexico IDEeA Networks of Biomedical Denis Bragin Georgia State University Research Excellence $253,763 National Institutes of Health Mining the Genome-Wide Scan: Genetic Brain Injury Treatment by Modulation of Profiles of Structural Loss in New Mexico State University Hemodynamics With Blood-Soluble Schizophrenia $24,954 New Mexico IDEeA Networks of Biomedical Drag-Reducing Molecules $334,869 Research Excellence - UNM HSC- Georgia State University Continuation $160,116 Andrew Carlson Mining the Genome-Wide Scan: Genetic Los Alamos National Laboratory Profiles of Structural Loss in Schizophrenia - New Mexico State University LANL Collaboration $50,000 Continuation $16,544 New Mexico IDEeA Networks of Biomedical Research Excellence - Mishra Specific Polyganics BV Jessica Dawn Richardson Supplement $151,500 ENCASE II: Randomized, Two-Arm, New Mexico Governor's Commission Multicenter Study to Evaluate the Safety on Disability New Mexico State University and Effectiveness of Dura Sealant Patch in Health Extension Rural Offices $25,000 New Mexico IDEeA Networks of Biomedical Reducing CSF Leakage Following Elective Research Excellence ACOMA_ Cranial Surgery $20,638 Bouchonville - Continuation $68,175 IRRAS AB New Mexico State University Professional Service Agreement $15,400 New Mexico IDEeA Networks of Biomedical Research Excellence $59,443 Muhammad Chohan NX Development Corp New Mexico State University 5-Aminolevulinic Acid (5-ALA) to Enhance New Mexico IDEeA Networks of Biomedical Visualization of Malignant Tumor in Research Excellence - Specific Patients With Newly Diagnosed or Supplement $51,342 Recurrent Malignant Gliomas - Non-Specific Supplement $7,200 National Institute of Neurological Disorders and Stroke William Rivers Spreading Depolarizations and Neuronal Lovelace UNM Rehabilitation Services Vulnerability $32,665 Pain Management Program Director $49,500 New Mexico State University A. Robb McLean New Mexico IDEeA Networks of Biomedical Holy Cross of Taos Research Excellence - Supplement $22,725 Hospital Service Agreement (ACCESS) - Continuation $125,000 Carlos Valenzuela National Institute on Alcohol Abuse Lea Regional Medical Center and Alcoholism Settlement Agreement $114,480 Alcohol and Developing Neuronal Circuits (MERIT Award) $378,750 Paradigm-Catastrophic Care Management Medical Directorship $25,000

40 unm health sciences center research annual report 2020 Peter Shin Lisa Hofler New Mexico Department of Health Presbyterian Healthcare Services RAD Non-Pending Toxicology Salary Professional Services/Consultations - RAD CRH Equipment $160,480 Support $75,000 Continuation $402,000 Society of Family Planning U.S. Department of Veterans Affairs DP Clinical Hofler Post Fellowship $60,000 VA Non-Forensic Autopsy Services Mitsubishi MT-3921-G01 $84,032 11/2019-11/2020 $30,804 Society of Family Planning Huy Tran COVID-19 Survey SFP $300 New Mexico Department of Public Safety University of Arizona 2020 Funding Paul Coverdell Base $29,808 Brain Oxygen Optimization in Severe Yuko Komesu Traumatic Brain Injury – Phase 3 Cook MyoSite Eastern New Mexico Medical Center (BOOST-3) $102,381 Protocol 15-06: CELLEBRATE: An Adaptive Autopsy Services $25,000 Two-Stage, Double-Blind, Stratified, Obstetrics & Gynecology Randomized, Controlled Trial Comparing Bureau of Indian Affairs the Safety and Efficacy of AMDC-USR Autopsy Services - Specific Nicholas Andrews With Placebo in Female Subjects With Supplement $24,863 AbbVie Stress Urinary Incontinence - Non-Specific New Mexico Department of Health Protocol #m16-837: Phase 2 Multicenter, Supplement $108,334 Double-Blind (Sponsor-Unblinded), FY20 - FY21 N.M. Violent Death Randomized, Placebo-Controlled Study of Research Triangle Institute Reporting System $5,275 the Safety and Efficacy of Elagolix in Women PFDN Capitation $93,141 Memorial Medical Center With Polycystic Ovary Syndrome $776,820 Eunice Kennedy Shriver National Institute Autopsy Services - Memorial Medical Conrad Chao of Child Health and Human Development Center $5,000 New Mexico Department of Health Innovations in Treatments for Pelvic Floor U.S. Attorney's Office High-Risk Prenatal Care $82,460 Disorders: PFDN Center Grant - Expert Witness Agreement 12/31/19- Continuation $18,180 Gena Dunivan 6/30/20 $2,500 Viveve, Inc Eunice Kennedy Shriver National Institute Sarah Lathrop Protocol VI-15-01: VIVEVE II: Viveve Geneveve of Child Health and Human Development New Mexico Department of Health Treatment of the Vaginal Introitus to Evaluate Innovations in Treatments for Pelvic Floor FY20 - FY23 Opioid Mortality Safety and Efficacy - Continuation $6,400 Disorders: a Southwestern PFDN Site Surveillance $720,038 Center Grant - Continuation $18,180 Viveve, Inc New Mexico Department of Health Protocol VI-15-01: VIVEVE II: Viveve Geneveve Felicia Mancini FY20 Opioid Mortality Surveillance $59,280 Treatment of the Vaginal Introitus to Michigan State University Evaluate Safety and Efficacy - Non-Specific ROSES - The ROSE Sustainment Study $2,160 U.S. Consumer Product Safety Supplement $3,753 Commission Sarah Martinez MECAP Reports $1,008 Eve Espey New Mexico Department of Health First Choice Community Healthcare Provide Risk-Appropriate Prenatal Ian Paul Midwifery Services $89,244 Medical Services to Medically Indigent U.S. Department of Justice Women in New Mexico With Obstetrical USA v. Xavier Z $5,217 Albuquerque Area Indian Health Service and/or Medical Complications - OBGYN IHS Specialty Services $72,490 Continuation $54,960 Lori Proe New Mexico Crime Victims Reparation New Mexico Department of Health Office of the Medical Investigator Commission Provide Risk-Appropriate Prenatal Medical FY20 Grief Services Program $104,643 Services to Medically Indigent Women in Lauren Decker New Mexico With Obstetrical and/or Medical New Mexico Department of Health National Center for Chronic Disease Complications - Continuation $54,960 FY20 Mass Fatality Planning $39,879 Prevention and Health Promotion New Mexico Perinatal Collaborative Lauren Dvorscak OMI-UNM SUID SDY Application $60,775 Director of Maternal Health New Mexico Department of Public Safety Orthopaedics & Rehabilitation Initiatives $50,000 2019 Coverdell Project ECHO (2020 Funding) $118,486 Marybeth Barkocy New Mexico Department of Health Move Together Inc. Certified Nurse Midwife Contractor U.S. Attorney's Office Move Together $2,000 Project W/BAA $25,500 Expert Witness Services USA v. Daniel Morgan $5,174 Thomas Decoster Planned Parenthood of the Rocky Arthrex, Inc. Mountains Heather Jarrell Arthrex Trauma Fellowship Planned Parenthood of the Rocky Bureau of Indian Affairs 2019-2020 $5,000 Mountains - Continuation $25,000 Autopsy Services - Continuation $179,000

unm health sciences center 2020 / contracts and grants 41 Imaging the Early Events in Membrane Receptor Signaling $420,193 Dennis McCance University of Virginia Biospecimen Procurement and Tissue Microarray Manufacture for the CHTN $128,337 University of Virginia Biospecimen Procurement and Tissue Microarray Manufacture for the CHTN - Continuation $128,337 Jay Raval Anonymous Clinical Trial Agreement $61,356 Market Therapeutics AG Plasma Adsorption in Patients with Gilbert Duxbury Cory Broehm COVID-19 Infection $35,840 Johnson & Johnson TriCore Reference Laboratories Samuel Reynolds Adolescent Spinal Deformity Tutorial $1,395 PSA_TriCore_Roche_Natify Mutation TriCore Reference Laboratories Profiler Early Evaluation Program Task Order # 3 Hamamatsu Photonics Beth Jones Alphas Site $11,600 Langford Consulting, Inc. K.K._Hamamatsu Study $54,800 Professional Services Agreement - Devon Chabot-Richards TriCore Reference Laboratories Continuation $35,044 TriCore Reference Laboratories Task Order # 2 Ventana/Roche CINtec PSA_TriCore_Roche_Natify Mutation Plus Slide Reads $6,790 Dustin Richter Profiler Early Evaluation Program Arthrex, Inc. Alphas Site $11,600 Larry Sklar Arthrex Sports Medicine Fellowship University of Miami 2019-2020 $20,000 Nadja Falk Illuminating the Druggable Genome TriCore Reference Laboratories Resource Dissemination and Outreach Robert Schenck Task Order # 5 Ventana Molecular Center - Continuation $372,727 Smith & Nephew, Inc Systems, Inc. _PDL-1 (SP142) BC Smith & Nephew Consulting ILR Study $10,400 National Institutes of Health Agreement $15,500 A High-Throughput Chemical Screen to Edgar Fischer Identify Inhibitors of the Azole Transporter University of Pittsburgh TriCore Reference Laboratories Cdr1p in Candida - Continuation $178,678 Surgical Timing and Rehabilitation for Task Order #1_Ventana Medical Systems, Multiple Ligament Knee Injuries: A Inc. _Ventana PDL1 GEJ ILR $4,800 Boston Children's Hospital Multicenter Integrated Clinical Trial $8,014 Compounds That Block a Novel Candida Jennifer Gillette Albicans Target $73,106 University of Pittsburgh National Institutes of Health Surgical Timing and Rehabilitation for Functional Role of Tetraspanin CD82 Gilead Sciences Multiple Ligament Knee Injuries: in Hematopoietic Stem Cell Evaluation of Novel Probes - Supplement A Multicenter Integrated Clinical Trial - Interaction $378,750 Continuation $73,100 Continuation $6,838 National Cancer Institute University of Pittsburgh University of Pittsburgh The Impact of CD82 Expression on Acute Purposing Pharmacological Agents STaR-RedCap Qtrly Report March 20 $5,363 Myeloid Leukemia Chemosensitivity and for Inherited Mast Cell Disorders in University of Pittsburgh Disease Relapse - Continuation $33,900 the Gut $66,660 Surgical Timing and Rehabilitation for National Institutes of Health University of Miami Multiple Ligament Knee Injuries: Functional Role of Tetraspanin CD82 in Illuminating the Druggable Genome A Multicenter Integrated Clinical Trial - Hematopoietic Stem Cell Interaction - Resource Dissemination and Outreach Specific Supplement $4,689 Specific Supplement $4,045 Center Supplement $56,840 Pathology Nancy Joste Gilead Sciences Margaret Alba TriCore Reference Laboratories Evaluation of Novel Probes $51,733 American Society for Clinical Pathology Medical Directorship and Professional Services - Continuation $2,569,091 Angela Wandinger-Ness Real-Time Interactive Lab Experience to National Institute of General Medical Increase Emotional Intelligence and Diane Lidke Sciences Problem-Solving Skills in Medical Lab National Institute of General Medical Academic Science Education and Science Students $2,000 Sciences Research Training $1,062,838

42 unm health sciences center research annual report 2020 National Cancer Institute Thornburg Foundation Catheter-Related or Central Line- The Role of Rac1 in Ovarian Cancer Sustaining Home Visiting Referrals $85,000 Associated Bloodstream Infection $1,500 Metastasis and Niche Interaction $34,494 Presbyterian Healthcare Services Sara Del Campo de Gonzalez Jain Zhou REACH $72,000 Harvard Graduate School of Education TriCore Reference Laboratories HERO II $69,908 Task Order #4 Hamamatsu Photonics Albuquerque Public Schools K.K._Hamamatsu Study $54,800 APS 1807 $69,000 Harvard Graduate School of Education Health's Early Roots & Origins - Albuquerque Public Schools Pediatrics Continuation $28,952 APS 1807 $45,471 Shirley Abraham Darrell Dinwiddie New Mexico Coalition of Sexual Assault Oregon Health & Science University National Institutes of Health Programs, Inc. Community Counts - Continuation $26,407 The Effect of 17q21 Locus SNPs on Targeted CAC Needs Assessment $35,000 Host Immune Responses in Children American Thrombosis and Hemostasis National Dance Institute - N.M. With Rhinovirus-Induced Exacerbations Network ATP Evaluation $15,500 of Asthma $240,794 ATHN Data Quality Counts $1,000 Presbyterian Healthcare Services Timothy Dionne Novo Nordisk, Inc. Mobile Food Market FY20 $10,000 HRSA/Bureau of Health Professions NN7415-4322: A Prospective Multi-National, HRSA Scholarship for Disadvantaged Non-Interventional Study in Haemophilia New Mexico Public Education Department Students $650,000 A and B Patients With or Without PED Evaluation - Specific Inhibitors Treated According to Routine Supplement $10,000 Sandra Heimerl Clinical Treatment Practice - Non-Specific HRSA/Maternal and Child Health Bureau Supplement $961 Sally Davis NM LEND Program $699,000 Centers for Disease Control and Prevention Tanya Baker-McCue PRC Research $440,253 Association of University Centers on New Mexico Division of Vocational Disabilities Rehabilitation New Mexico Human Services Department Focused Assistance to Support DVR School to Work Project $400,000 CHILE Plus $335,251 Training $8,000 Anthony Cahill Centers for Disease Control and Prevention New Mexico Developmental Disabilities American Association on Health Healthy Places – Healthy People $309,483 Planning Council & Disability NM LEND Interdisciplinary Advocacy New Mexico Department of Health Project Accessibility USA: Health Promotion Workshop $2,500 Implementing Evidence-Based for Women With Disabilities $20,000 Recommendations in Community Projects - Andrew Hsi Glenda Canaca Continuation $41,940 New Mexico Department of Health New Mexico Human Services Department DDSD FIT (FOCUS) $116,000 New Mexico Department of Health Social Marketing - Continuation $465,150 Implementing Evidence-Based Alberta Kong Loretta Cordova De Ortega Recommendations in Community New Mexico Department of Health New Mexico Department of Health Projects $34,940 School-Based Health Center CMS Outreach $1,520,513 Services $1,797,200 Walter Dehority Comagine Health Syneos Health Oregon Research Behavioral Intervention In-Home Assessments for Medically Pfizer Peds CAZ-AVI Nosocomial Strategies, dba Influents Innovations Fragile Waiver W/BAA - Pneumonia Study #c3591025 $24,814 A Mobile/Web-Based Training Curriculum Continuation $102,125 for Disseminating Best Practices for the Medpace Inc Care of Newborns With Neonatal Opioid MDA 2013-0039: A Phase 3 Multi-Center Ben Archer Health Center, Inc. Withdrawal Syndrome $84,077 Professional Services - Study to Evaluate the Efficacy and Safety Continuation $25,000 of Mino-lok Therapy in Combination With Klein Buendel Systemic Antibiotics in the Treatment of Web App Technology for Boys and Northern Navajo Medical Center Catheter-Related or Central Line-Associated Parents: Improving HPV Vaccine Uptake - IHS Service Contract - Genetics $4,800 Bloodstream Infection - Specific Continuation $30,000 Supplement $12,800 Rio Rancho Public Schools Albuquerque-Bernalillo County PSA - Rio Rancho Public Schools $3,000 Infectious Disease Society of America Community School Partnership G.E.R.M Mentorship Award $4,000 Theresa Cruz Professional Services $27,900 New Mexico Human Services Department Medpace Inc SNAP-Ed Evaluation $259,281 MDA 2013-0039: A Phase 3 Multi-Center Brindle Foundation Study to Evaluate the Efficacy and Safety UNM Envision/Optimizing Care for Neonatal New Mexico Department of Health of Mino-lok Therapy in Combination With Opioid Withdrawal Syndrome in Rural Youth Risk and Resiliency Survey $190,000 Systemic Antibiotics in the Treatment of New Mexico $25,000

unm health sciences center 2020 / contracts and grants 43 John Kuttesch University of California, San Francisco New Mexico Department of Health Hyundai Motor America (Hope High-Dose Erythropoietin for Asphyxia Early Childhood Network $492,400 on Wheels) and Enciphalopathy CCC Project - 2019 Hyundai Hope on Wheels Impact Non-Specific Supplement $1,142 New Mexico Department of Health Grant $100,000 Early Childhood Network $485,000 Peggy MacLean Children's Hospital of Philadelphia Early Childhood Education and Care Falling Colors Corporation Health Effects After Anthracycline and Department Early Childhood Infrastructure Radiation Therapy - Dexazoxane and Level 2 NICU Hatch $1,596,976 Development $480,000 Prevention of Anthracycline-Related New Mexico Children, Youth & Families New Mexico Department of Health Cardiomyopathy (ALTE11C2 Study) DDSD Statewide Training Database $185,480 (NIH R01) - Specific Supplement Department Amendment 1 $90,900 Level 2 NICU $498,488 New Mexico Department of Health CMS Medical Home Portal Project $150,000 Children's Hospital of Philadelphia Michael Marble Protocol: ANBL1531 Phase 3 Clinical New Mexico Department of Health Nurse-Family Partnership Study (Industry) $89,960 CMS Newborn Screening $349,416 Nurse-Family Partnership Incentive $132,696 Children's Hospital of Philadelphia Jane McGrath Falling Colors Corporation Clinical Trial - Non-Industry - New Mexico Department of Health Infant Mental Health Team Community Continuation $75,000 Long-Acting Reversible Contraception of Practice $125,000 Training and Stocking Project - Specific Children's Hospital of Philadelphia Supplement $950,000 New Mexico Department of Health EVERYCHILD (APEC4B1) PCR - COG DDSD Statewide Training Database $122,696 Foundation- Continuation $62,464 New Mexico Department of Health Long-Acting Reversible Contraception New Mexico Department of Health Children's Hospital of Philadelphia Training and Stocking Project - Specific Project SET (Specialized Early Clinical Study Protocol AALL0434 - Novartis Supplement $700,000 Training) $106,191 Pharmaceuticals Corp. (Industry) - Continuation $58,880 New Mexico Department of Health New Mexico Department of Health Long-Acting Reversible Contraception DDSD Informed Choice $100,000 Children's Hospital of Philadelphia Training and Stocking Project - Specific New Mexico Department of Health Clincial Trial: EOY, Integrated BIQSFP Supplement $300,000 AAML1031- Echocardiogram Reports DDSD Informed Choice $100,000 New Mexico Department of Health and Images (Non-Industry) $40,000 New Mexico Department of Health Long-Acting Reversible Contraception Medically Fragile Case Children's Hospital of Philadelphia Training and Stocking Project - Specific Management $86,000 COG NCTN Network Group Operations Supplement $60,000 - Work Load Intensity (NCTN Grant New Mexico Department of Health Shiraz Mishra 2U10CA180886) $16,000 Medically Fragile Program $86,000 National Institutes of Health Children's Hospital of Philadelphia Enhancing Prevention Pathways Towards New Mexico Department of Health COG NCTN Network Group Operations - Tribal Colorectal Health - Continuation $1 New Mexico SAFE Program $83,437 Per Case Reimbursement (2U10CA180886) $16,000 Marcia Moriarta New Mexico Department of Health New Mexico Department of Health New Mexico Safe Program $83,437 Children's Hospital of Philadelphia DOH Autism Programs $3,431,040 Protocol: ADVL1322/Novartis: Clinical Falling Colors Corporation Trial Agreement $11,500 New Mexico Department of Health Parent-Infant Psychotherapy $75,000 DOH Autism Program $3,431,040 Children's Hospital of Philadelphia New Mexico Department of Health Logitudinal, Multimodal Assessment of New Mexico Department of Health Children's Medical Services Evaluation Neuro (HR-ALL) ALTE07C1 (Nonindustry Medically Fragile Waiver $2,940,444 Project $65,000 R01CA212190) $7,575 New Mexico Human Services Department New Mexico Children, Youth & Families Jean Lowe Improving Quality (75/25 & 50/50 Department University of Utah Medicaid Match) $2,000,000 ACA - Parents As Teachers Valencia DARBE $179,529 County $60,000 New Mexico Department of Health University of California, San Francisco Early Childhood Evaluation Program SGF/ New Mexico Department of Health High-Dose Erythropoietin for Asphyxia Part B/part C $1,232,000 DDSD PFE Transition Project $50,000 and Encephalopathy Project $24,157 New Mexico Department of Health Falling Colors Corporation University of California, San Francisco DDSD Partners for Employment $562,800 IMH Foster Parent $50,000 High-Dose Erythropoietin for Asphyxia New Mexico Department of Health New Mexico Department of Health and Encephalopathy CCC Project - DDSD Partners for Employment $562,800 DDSD Partners for Employment Transition Non-Specific Supplement $8,574 Project $50,000

44 unm health sciences center research annual report 2020 Early Childhood Education and Care Silver Consolidated Schools Pacific Institute for Research & Evaluation Department RBT Supervision - Continuation Implementing School Nursing Strategies CDD Preschool Development Grant - FY20 $9,545 to Reduce LGBTI Adolescent Suicide - Specific Supplement $30,000 Continuation $51,809 Estancia Municipal Schools Brindle Foundation Estancia Consultations $5,775 Pacific Institute for Research & Evaluation Brindle - Clinical Consultation for Implementing School Nursing Strategies Moriarty-Edgewood School District Rural Providers $25,000 to Reduce LGBTI Adolescent Suicide - Moriarty-Edgewood School District $5,765 Continuation $43,681 Administration for Community Living Hengameh Raissy University Center for Excellence in Health Resources and Services Savara Pharmaceutical Developmental Disabilities $23,000 Administration Phase 3 Randomized, Double-Blind, Continuation $40,826 New Mexico Department of Health Placebo-Controlled Study of Aerovanc DDSD Statewide Training Database $2,849 for the Treatment of Persistent Methicillin- Albuquerque Public Schools Resistant Staphylococcus Aureus Lung Marketing Material for School-Based Health Martha Muller Infection in Cystic Fibrosis Patients - Centers $15,000 Merck, Sharp & Dohme, Inc. Continuation $74,999 Merck MK1439-066 & MK8591A-028 $500 A. Robb McLean Duke University Albuquerque-Bernalillo County Dawn Novak Pharmacokinetics and Safety of Community School Partnership New Mexico Department of Health Anesthetics and Analgesics in Children - Professional Services - Developmental Care Continuity Program - Continuation $48,480 Continuation $40,000 Fee for Service - Continuation $179,400 Vertex Pharmaceuticals Incorporated Leslie Strickler New Mexico Department of Health A Phase 1/2 Study of VX-445 in Healthy New Mexico Crime Victims Reparation Developmental Care Continuity Subjects and Subjects With Cystic Commission Program - Fee for Service $147,400 Fibrosis - Continuation $32,000 CVRC - SAS State Grant $352,600 New Mexico Department of Health Vertex Pharmaceuticals Incorporated New Mexico Crime Victims Reparation Developmental Care Continuity A Phase 1/2 Study of VX-445 in Healthy Commission Program - Cost $32,000 Subjects and Subjects With Cystic Fibrosis - ACCESS - VOCA Federal Grant $72,064 Non-Specific Supplement $11,947 Julia Oppenheimer U.S. Department of Justice Association of University Centers on Savara Pharmaceutical Expert Witness Contract - Lewis $6,898 Disabilities Phase 3 Randomized, Double-Blind, Placebo- Children’s Mental Health Champions $6,000 Controlled Study of Aerovanc for the New Mexico Coalition of Sexual Assault Treatment of Persistent Methicillin-Resistant Programs, Inc. Patricia Osbourn NMCSAP - Educational Delivery $650 New Mexico Public Education Department Staphylococcus Aureus Lung Infection PED Prek Consultation $947,685 in Cystic Fibrosis Patients - Non-Specific Monique Vallabhan Supplement $6,695 Health Resources and Services New Mexico Public Education Department Administration PED Prek Consultation $440,990 Vertex Pharmaceuticals Incorporated Phase 3 Clinical Trial - Non-Specific Telehealth Network Grant $355,554 New Mexico Public Education Department Supplement $126 Jennifer Vickers PED Contract - SET & DB $429,950 Mary Ramos New Mexico Department of Health Region IX Education Cooperative County of Bernalillo CORE $1,501,100 Region IX Education Cooperative $215,153 Professional Service Agreement - New Mexico Department of Health Continuation $200,000 U.S. Department of Education CORE $1,501,100 Project for New Mexico Children Who Are Deaf-Blind $107,912 Socorro Consolidated Schools Socorro School Consultations $14,850 Silver Consolidated Schools Silver Consolidated Schools Consultations FBA $14,586 Belen Consolidated Schools Belen Consultations - Specific Supplement $13,420 Cuba Independent Schools Cuba Consultations $10,175

unm health sciences center 2020 / contracts and grants 45 New Mexico Behavioral Health Collaborative Emergency Response to COVID-19 $150,000 Falling Colors Corporation Multi-Systemic Therapy Data Reporting Initiative - FY20 $31,400 New Mexico State University Adolescent Substance Use Reduction Effort – Treatment Implementation $15,000 Caroline Bonham Indian Health Service IHS Tele-Behavioral Health, Training & Consultation $300,000 Indian Health Service IHS Tele-Behavioral Health, Training & Consultation - Non-Specific Supplement $298,637 New Mexico Department of Health Children's Mercy Hospital Indian Health Service Continuum of Care Main $878,800 CKiD Steering Committee - Non-Specific IHS Tele-Behavioral Health, Training Supplement $2,659 & Consultation $200,000 New Mexico Department of Health Continuum of Care $858,800 Children's Mercy Hospital Albuquerque Area Indian Health Service CKiD IV - Non-Specific Supplement $1,410 IHS-AAO Substance Abuse & Mental New Mexico Department of Health Health Clinical & Community Education, Mortality Review Project $114,800 Children's Mercy Hospital Training & Outreach Services $99,000 CKiD Steering Committee - Non-Specific New Mexico Department of Health Supplement $910 New Mexico Human Services Department Mortality Review - Supplement $62,136 HNL Supplement (CBHTR II) $95,300 Elizabeth Yakes Jimenez New Mexico Department of Health W.K. Kellogg Foundation Indian Health Service Mortality Review $52,750 The THRIVE Project $175,000 IHS Tele-Behavioral Health, Training & Consultation - Project ECHO Kristi Watterberg New Mexico Public Education Department Supplement $27,158 Eunice Kennedy Shriver National Institute Improving Health and Academic of Child Health and Human Development Success Grant $21,300 Juan Bustillo NICHD Cooperative Multicenter Neonatal Janssen Scientific Affairs, LLC Network $269,762 New Mexico Children, Youth & Families Clinical Trial Agreement - Phase 3 - Department Non-Specific Supplement $57,464 Carla Sue Wilhite Plans of Care Webinars $10,206 New Mexico State University Otsuka Pharmaceutical Development New Mexico Agrability - Assistive Gretchen Swanson Center for Nutrition & Commercialization, Inc. Technology Program for Farmers With Develop and Test a Brief Supplemental Food Otsuka-Bustillo $984 Disabilities $12,141 Security Module That Aims to Add Utility When Used Alongside the USDA Household Jennifer Crawford New Mexico State University Food Security Survey Module $5,361 Falling Colors Corporation New Mexico Agrability - Assistive Technology Adolescent Substance Use Reduction Program for Farmers With Disabilities - Psychiatry & Behavioral Sciences Effort – Treatment Implementation Specific Supplement $9,311 (with CYFD) 2020 $74,088 Christopher Abbott New Mexico State University National Institutes of Health Annette Crisanti New Mexico Agrability - Assistive ECT Current Amplitude and Medial Temporal National Institute of Mental Health Technology Program for Farmers With Lobe Engagement - Continuation $501,545 Feasibility of an Early Detection Program Disabilities $5,000 for Early Psychosis on a College Campus Georgia State University (Reducing DUP) $225,418 Craig Wong Data-Driven Approaches to Identify Children's Mercy Hospital Biomarkers From Multimodal Imaging National Institute of Mental Health CKiD IV $16,911 Big Data $21,807 Feasibility of an Early Detection Program for Early Psychosis on a College Campus Nationwide Children's Hospital Deborah Altschul (Reducing DUP) - Year 2 $225,196 Cure Glomerulonephropathy - San Felipe Pueblo Continuation $15,500 San Felipe KEYWAH III $735,500 City of Albuquerque APD Crisis Intervention Team ECHO Program Coordinator $75,000

46 unm health sciences center research annual report 2020 Falling Colors Corporation Mauricio Tohen Student Services Opening Doors for Homeless $46,088 County of Bernalillo Psychiatric Services - Continuation $89,000 Sheila Hickey Lucas Dunklee Health Resources and Services Massachusetts General Hospital Otsuka Pharmaceutical Development Administration Augmentation Versus Switch: Comparative & Commercialization, Inc. School of Medicine M.D. Scholarship Effectiveness Research Trial for Otsuka-Tohen $1,125 for Disadvantaged Students $650,000 Antidepressant Incomplete and Non- Responders With Treatment-Resistant Ann Waldorf Surgery Depression - Continuation $271,035 Center for Substance Abuse Treatment Provider’s Clinical Support System (PCSS- Steven Bock Dawn Halperin Universities)- Continuation FY20 $150,000 Ethicon Otsuka Pharmaceutical Development Ethicon Travel Award $1,235 Center for Substance Abuse Treatment & Commercialization, Inc. Arup Das Otsuka-Halperin $681 Provider’s Clinical Support System (PCSS-Universities) - National Eye Institute Brian Isakson Continuation FY21 $150,000 Novel Biomarkers & Genetics of Diabetic

New Mexico Children, Youth & Families Retinopathy $535,606 Department Radiology New Mexico Commission for the Blind System of Care Expansion and Brad Cushnyr Emergency Eye Care Program - Sustainability $1,600,000 U.S. Attorney's Office Continuation $125,000 Expert Witness $19,294 First Choice Community Healthcare Dusanka Deretic First Choice Community Healthcare $25,000 Gary Mlady National Eye Institute First Choice Community Healthcare New Mexico Department of Health Rhodopsin Trafficking & Photoreceptor First Choice Community Healthcare - BCC Early Detection Program $126,941 Membrane Renewal $378,750 Continuation $25,000 Santo Domingo Health Center John Marek Avron Kriechman Physicist Services $50,000 W.L. Gore & Associates Vascular Surgery Support Program - New Mexico Department of Health Indian Health Service Continuation $4,000 Mescalero Suicide Prevention $55,000 Albuquerque Indian Health Service $35,000 John Russell Hidalgo Medical Services X-Ray Associates of New Mexico Eye Associates of New Mexico Hidalgo Medical Services $25,000 Medical Physicist Services - Professional Services $172,500 Rhoshel Lenroot Continuation $25,000 Presbyterian Medical Services Otsuka Pharmaceutical Development Indian Health Service On-Call Surgical Services - & Commercialization, Inc. Albuquerque Indian Health Service - Continuation $25,000 Otsuka-Lenroot $636 Continuation $7,000 Christopher Morris Falling Colors Corporation Systems of Care III - CYFD - UNM Medical Group $375,000 Judith Pentz The Weil Foundation Integrative Psychiatry for Residents and Child Fellows $15,000 Davin Quinn ICON Clinical Research RECOVER Study $154,048 Paul Romo Friends Research Institute, Inc. Facilitating the Implementation of Interim Methadone to Increase Treatment Access: A Multi-Site Implementation Trial $5,000 Julie Salvador Agency for Healthcare Research and Quality ECHO-F Model to Expand Medication- Assisted Treatment in Rural Primary Care $387,524

unm health sciences center 2020 / contracts and grants 47 Anil Shetty Bernalillo County Robert Perry New Mexico Department of Health CONNECT (OCCS) - Continuation $347,287 New Mexico Department of Health Cleft Palate Clinic Services $8,400 Emergency Preparedness $54,267 New Mexico Department of Health Joaquin Tosi Breast and Cervical Cancer Early Detection Suzanne Popejoy Genentech, Inc. Program - Continuation $85,000 City of Albuquerque GR40550: Phase 3 Study of the Port Delivery Scope of Services-Gang Prevention - System With Ranibizumab in Patients With Alberta Kong Continuation $239,378 Diabetic Macular Edema $3,447,720 Albuquerque-Bernalillo County Community School Partnership City of Albuquerque UNM HOSPITAL Professional Services $223,522 Early Intervention for Children Services - Continuation $215,632 Sarah Martinez Eve Espey New Mexico Department of Health A. Robb McLean New Mexico Department of Health Provide Prenatal and Postpartum Clinical New Mexico Department of Health Provide Prenatal and Postpartum Clinical, Health Education - Continuation $180,000 Provide Services for Hospital Preparedness - Health Education - Continuation $149,968 Continuation $23,448 Rodney McNease New Mexico Department of Health Bernalillo County Mauricio Tohen Provide Prenatal and Postpartum Clinical, CONNECT (OCCS) $1,389,148 County of Bernalillo Health Education - Continuation $320 Provide Housing to Homeless in Criminal Wendy Hine Bernalillo County Justice System - Continuation $498,726 New Mexico Department of Health CONNECT (OCCS) - Breast and Cervical Cancer Early Detection Continuation $1,148,584 UNM MEDICAL GROUP, INC. Program - Continuation $85,000 City of Albuquerque David Rakel Jill Klar Assertive Community Treatment Bernalillo County Juvenile Detention Bernalillo County Program - Continuation $713,330 Center Adverse Childhood Experiences - Professional Services - Continuation $614,804 Continuation $140,973

48 unm health sciences center research annual report 2020 How to Donate to UNM Health Sciences Center Research Join Us on Our Journey of Discovery

Our research programs are focused on critical health problems affecting New Mexicans and bridging the gap to more rapidly deliver discoveries to the clinical setting. Often, the benefits of our innovations and discoveries are recognized and shared beyond our state borders to institutions in other states and in countries around the world.

Your contributions will help us meet new challenges and seek solutions to help people lead longer and healthier lives. Donations are accepted through the UNM Foundation, the university-based nonprofit that can accommodate almost any giving interest. Options include support of health research in general, work in a particular disease category, one of our signature programs for scholarships or facilities, or a legacy gift customized to fit the wishes of you as an individual, your family or your company.

For more information on how you can contribute to the UNM Health Sciences Center’s discoveries and innovations of the future, contact Bill Uher, Vice President of Development, UNM Foundation, at [email protected] or 505-277-4078.

About the Foundation The University’s Board of Regents established the UNM Foundation in 1979 as a nonprofit corporation. Ten years later, the Regents delegated the responsibility of overseeing University of New Mexico assets and investments to the UNM Foundation Investment Committee. These assets total more than $400 million today.

In 2008, the Foundation became a stand-alone organization with expanded fiduciary duties to include fiscal, human resources and treasury functions. All private gifts to the Health Sciences Center are received through the UNM Foundation, which manages contributions to all university programs. The Foundation’s funding model ensures that 100 percent of gifts are directed to the donor’s designated purpose. OFFICE OF RESEARCH 1 University of New Mexico MSC08-4560, Fitz Hall B-61 Albuquerque NM 87131-0001

UNM HEALTH SCIENCES CENTER Discovery Research Annual Report 2020

TURNING RESEARCH INTO CURES