Business Plan

Reversing Aging Through Telomere Lengthening Contents

Business Summary 3 TAM Clinical Studies 13 Road Map Expectation 24 Company 4 Defytime Bill Andrews Requested Investment 25 Aging Care Capsules 14 Our Team 5 Cosmeceutical Estimated Sales 26 Defytime Aging Care Cream 15 Telomeres 6 Non-medicated Item Estimated Sales 27 Defytime Eye Serum 16 Telomerase 7 Cash Flow Analysis Assumptions 28 Defytime Deep Skin Express 17 What is Aging? 8 VVIP Medical Tour Estimated Sales 29 Defytime Aqua Oil Drops 18 Causes & Treatment of Aging 9 Company & Brand Structure 30 Defytime TAM Spray 19 Telomerase Induction Proposed Summary Terms 31 - Anti Aging Therapeutic 10 Proposed South Pacific Clinic 20 Company Structure 32 Telomerase Induction Inner Beauty NZ 21 Contracts 33 - Hybrid Vector Solution 11 Brand Marketing Strategy 22 TAM CO314818 12 SWOT Analysis 23

Business Plan 2 Business Summary

We have developed a genuine Our objectives are: anti aging solution called TAM. • To create products with TAM (Telomerase Activating Molecule) as an active ingredient. We now have a range of anti aging • To launch non-medicated and skin care products to introduce to the cosmetic market. products: mask patch, nasal spray • VVIP medical tour business. and dermal products. • To create telomere lengthening dermal products for anti aging and aging cure, and sell TAM products through sales channels. • To develop further premium anti aging products with TAM and non-medicated products. • South Pacific Clinic could provide genuine anti aging services to VVIP medical tour groups.

Business Plan 3 Company

Defytime Ltd is headquartered in Auckland New Zealand, with labs co-located in The University of Auckland and research and development in Reno, Nevada USA. Our first anti-aging clinic is located in Vanuatu. Our goal is to reverse the human aging process and cure diseases linked to aging by activating telomerase and thus extending telomeres, leading the cells to return to a state of youthful gene expression and function. This cutting edge research is led by director Dr. Bill Andrews. Dr. Andrews has worked in the biotech industry for over 35 years, focusing the last 20 years on finding ways to extend human lifespan through the intervention of telomere shortening in human cells.

Business Plan 4 Our Team

Dr. Bill Andrews Laura A. Briggs, Ph.D. Founder & President Vice President of Research & Discovery Dr. Andrews is the founder and President of Sierra Science Laura Briggs received her B.S. degree in Nutrition in 1993 and LLC, a biotech company in Reno, Nevada focused exclusively her Ph.D. in Environmental Science and Health in 2000 from on finding drugs that will transiently induce the expression of the University of Nevada, Reno. After a one year post-doctoral endogenous telomerase in human cells. position at UNR she joined Sierra Sciences, known as Andrews Inc in 2001. In addition to coordinating research and development at Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at Sierra Sciences, Dr. Briggs is also serving as the Biology Lab Coordinator the University of Georgia in 1981. He was a Senior Scientist at Armos Corp for Truckee Meadows Community College (TMCC) and has collaborated and Codon Corp, Director of Molecular Biology at Codon and at Geron on research projects at the V.A. Medical Center in Reno, Nevada. Corp, and Director of Technology Development at EOS Biosciences. While Director of Molecular Biology at Geron Corp from 1992 to 1997, Lancer Brown, M.S. Dr. Andrews was one of the principal discoverers of both the RNA and protein components of human telomerase and was awarded 2nd place Program Director of Screening as "National Inventor of the Year" in 1997 for this work. Lancer Brown received his B.S. and M.S. degrees in He is named inventor on 45 US issued telomerase patents. Dr. Andrews Biotechnology in 2003 from the University of Nevada, Reno is highly respected and widely known for his expertise and passion and was one of three students in the inaugural advanced BS/ for curing aging and TEDS. He has been a featured expert in many MS Biotechnology Program. He distinguished himself as the documentaries and is a frequent guest speaker at prestigious events. first student to complete the program. Lancer came to Sierra Sciences as Dr. Andrews is also an ultra marathon runner whose ultimate goal is an intern while completing his degree. Following graduation, he joined to run a 7-minute mile at the age of 130. Sierra Sciences full-time where he has proven to have remarkable ability to engineer genes and DNA. He has recently been promoted to Program Director of Screening.

Business Plan 5 Cell Telomeres Chromosome Telomere

Telomeres are an essential part of human cells that affect how our cells age. Cell division plays a critical role in normal growth, maintenance and DNA repair of all human tissues, including skin.

Telomeres are repeated sequences of DNA at the ends of each Telomere chromosome and are key genetic elements involved with the regulation of cell division. Telomeres shorten every time a cell divides, and once telomeres reach a critically short length, the cell either dies by apoptosis or stops dividing and senesces. Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, like the plastic tips at the end of shoelaces. Without the coating, shoelaces become frayed until they can no longer do their job, just as without telomeres, DNA strands become damaged and our cells can’t do their job. Telomeres are shortened as we age, but telomeres can also be shortened by stress, smoking, obesity, lack of exercise and a poor diet.

As cells divide over time telomeres shorten, and eventually cell division stops.

Business Plan 6 Telomerase

Telomerase is a naturally occurring enzyme that maintains telomeres and prevents them from Telomerase shortening during cell division. Telomerase, also called telomere terminal transferase, is a ribonucleoprotein that adds the polynucleotide “TTAGGG” to the 3’end of telomeres, at the ends of eukaryotic chromosomes. U C Telomerase is a reverse transcriptase enzyme that carries its own RNA RNA template C C A A molecule (with the pattern of ”CCCAAUCCC” in vertebrates), which is G T A used as a template for adding new bases onto the ends of telomeres. G G AT DNA

Nucleotide

Business Plan 7 What is Aging?

Ageing (British English) or aging (American English) is just the process of becoming older. The term is used to refer to biological aging of human beings, animals and other organisms, but can also refer to individual cells within an organism (cellular aging) or to the population of a species (population aging). In humans, aging is an accumulation of changes over time, encompassing physical, psychological, and social change. Reaction time may slow with age, while knowledge and wisdom may expand. Aging is one of the greatest contributing risk factors for most human diseases, and of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes.

Business Plan 8 Causes & Treatment of Aging The activation of telomerase in aged mice rejuvenates the entire body

Telomerase Induction The causes of aging can be ascribed to damage, whereby the accumulation of externally induced damage (such as DNA point mutations) may cause biological systems to fail, or to programmed aging, whereby internal processes (such as DNA telomere shortening) may cause aging. Telomere-shortening can be seen as a programmed aging ‘disease’, and could be cured by lengthening telomeres via Telomerase Induction.

Defytime proposes 2 different Telomerase Induction methods: • Anti Aging Therapeutic used in creams, supplements, and drugs • Hybrid Vector Solution (injection of a virus), available in our clinic in With telomerase aging is reversed Without telomerase aging continues Vanuatu for VVIP patients. The next 2 pages explain how these processes work.

Business Plan 9 Repressor Anti Aging Therapeutic Protein no Telomerase production

Chromosome

Telomerase Induction Method 1 Regulator Site Telomerase Gene Telomerase can be naturally produced by your cells to repair telomeres, but this function is shut off by a repressor protein binding to a regulator site or ‘switch’ on the chromosome.

• Defytime introduces a therapeutic element that binds to the Repressor repressor protein. Protein Telomerase production activated • This prevents the repressor protein from binding to the regulator site, Anti-aging Therapeutic allowing telomerase production to be activated. Chromosome • The telomerase produced by your cells can then repair the portions of the telomeres lost in cell division. Regulator Site Telomerase Gene

Business Plan 10 Hybrid Vector Solution + = Cloning Activated Adeno-Associated Virus Human Telomerase Gene (AAV) Viral Vector Hybrid Vector Telomerase Induction Method 2 In Defytime Telomere Lengthening Therapy, a hybrid vector combining the activated human telomerase gene with an adeno associated virus (AAV) is made and cultured. • The adeno associated virus does not cause disease, and has a very mild immune response. • The AAV transfers the hybrid vector (section of DNA) into your cells, where it can produce telomerase. • The telomerase produced by your cells can then repair the portions of the telomeres lost in cell division. Transfers into cells and onto Hybrid vector solution genomic DNA to produce telomerase. injected into the bloodstream

Business Plan 11 TAM CO314818

Telomerase Activating Molecule Developed by Bill Andrews, Ph. D. (Sierra Sciences, LLC.) in 2014, TAM CO314818 is a state of the art Telomerase Activating Molecule (TAM) that counteracts and suppresses the fundamental cause of aging: telomere shortening. By interfering with the action of telomerase inhibiting substances TAM CO314818 induces telomerase to function normally and to cause cell division to become more active leading to younger and healthier cells. TAM is the most effective anti-aging compound available, being 300 times more effective than TA65 - currently the strongest telomerase inducer in the market. The TAM compound is mixed with other ingredients for oral and dermal products. All Defytime products feature the TAM logo to indicate they contain the TAM compound.

Business Plan 12 TAM Clinical Studies

Excellent improvement of skin condition over 30 days Clinical trials in vivo in Italy (Abich Labs in cooperation with San Raffaele Hospital) proved the strong anti-aging properties of our TAM products. • 100 women tested, 36-65 years old • Applied twice daily, 20ug/ml TAM • Tested on day 0, 15, 30

Day 0 Day 15 Day 30

Business Plan 13 Defytime Bill Andrews Aging Care Capsules

With Telomerase Activation • Defytime Dr. Bill Andrews anti-aging dietary supplement with TAM improves biological health (skin, vessels, brain, bone). • Made in New Zealand from quality ingredients. • TAM targets telomeres in cells, leading to younger and healthier cells. • TAM is the most effective anti-aging compound available.

Business Plan 14 Defytime Aging Care Cream

With Telomerase Activation • Defytime Aging Care Cream with TAM counteracts and suppresses the fundamental cause of skin aging: telomere shortening. Skin cells are rejuvenated, youthful elasticity is restored, fine lines and wrinkles disappear. • A state of the art natural micro-emulsion optimized to deliver TAM to achieve maximum results. • Made in New Zealand from quality ingredients. • TAM targets telomeres within skin tissue, leading to younger and healthier skin cells. • TAM is the most effective anti-aging compound available.

Business Plan 15 Defytime Eye Serum

With Telomerase Activation • Defytime Eye Serum with Jojoba Oil and Macadamia Seed Oil Esters along with TAM acts to prevent premature aging of the skin. • Made in New Zealand from quality ingredients. • TAM targets telomeres within skin tissue, leading to younger and healthier skin cells. • TAM is the most effective anti-aging compound available.

Business Plan 16 Defytime Deep Skin Express

Rejuvenating Eye Patch with Telomerase Activation • Defytime Deep Skin Express rapidly delivers active ingredients into the deep dermal layer of the skin for lasting effects. • Convenient and fast application (1 minute). • Over 1.5mm absorption into the dermal layer after 50 minutes. • Made in New Zealand from 100% natural and sustainable ingredients. • Dermal tested and hypoallergenic. • TAM targets telomeres within skin tissue, leading to younger and healthier skin cells, and is the most effective anti-aging compound available.

Business Plan 17 Defytime Aqua Oil Drops

With Telomerase Activation • Defytime Aqua Oil Drops with Rosehip Oil, Macadamia Oil and Astaxanthin Oil along with TAM offers a wide range of skin health benefits when used regularly. • Made in New Zealand from quality ingredients. • TAM targets telomeres within skin tissue, leading to younger and healthier skin cells. • TAM is the most effective anti-aging compound available.

Business Plan 18 Defytime TAM Spray

With Telomerase Activation • Defytime TAM Spray with Aqueous Propolis helps to improve biological health, while preventing dry mouth, tooth decay and gum disease naturally. • Made in New Zealand from natural ingredients and free of sugar and preservatives. • Promotes production of saliva as well as providing active anti-bacterial properties against tooth decay, gingivitis and bad breath. • TAM targets telomeres in cells, leading to younger and healthier cells, and is the most effective anti-aging compound available.

Business Plan 19 South Pacific Clinic

Business Plan 20 Inner Beauty NZ Drink Anti Aging Care Water In the South Pacific we can host an Anti Aging Center for clinical treatment of VVIP. Defytime Nasal Spray can deliver TAM efficacy as a key inner beauty item, along Care with other treatments. Anti Aging Dermal Products & Nasal Spray

Eat Anti Aging Capsules

Business Plan 21 Brand Bill’s Give lectures Introduce Bill name as top and create and his work Telomere supporters through internet lengthening through social and mass media Scientist networks

Prove the Keep updating Marketing mechanism evidence and Strategy with third party proof tests Brand Marketing Products Create sales Produce and Strategy connected with channels for introduce new Bill’s name mass sales products

Business Plan 22 SWOT Analysis

Strength Opportunity SWOT Genuine anti aging and cure Unlimited market • As a new idea it may take time for consumers to understand the mechanism, aging solution but when consumers accept the idea it will create a huge market for the long term. • So, we need to spend time and money on Threat marketing and branding Bill’s name as the Weakness Similar products could create leading telomere expert. We also need to New mechanism confusion for consumers find the right channels to sell.

Business Plan 23 Road Map Expectation

Aug 30, 2019 Sep 30, 2019 Mar 30, 2020 Jun 30, 2020

Business Plan Aug 20 - 30 2019 (restructure web sites)

Market Research ~Aug 20, 2019 (market testing already completed)

Complete Contract Completed 28th September, Reno USA

Set Up Company Completed July 10, 2019 (Defytime Singapore - expecting initial fund)

Invest Fund August 30, 2019 (invest actual fund)

Order the Machines Sep 15 (1st machine with initial fund)

Produce Samples March 15 - Aug 30, 2019 (by Defytime, NZ)

Test Production February - Aug 2019

Viral Injection Sales Only for VVIP 2020 by booking / 3 clinical tests

Mass Production & Sales

Business Plan 24 Requested Investment Total: US$19Million

Details Amount (US$) Notes

License fee 3 Million

NZ clinic center (South Pacific) 5 Million Includes property cost

Viral clinic tests 2 Million 3 persons

Viral manufacturing factory setup costs 1 Million

New drug development costs 2 Million Until clinic phase 2/A

Marketing costs for dermal and oral 3 Million Branding, PR

Manufacturing costs for cosmetics 2 Million Mask patch, serum, cream, oral & nasal spray, capsules, oil

Operation costs 1 Million Yearly

Total 19 Million

Business Plan 25 Cosmeceutical Estimated Sales

Financial Years Ending March 31 2019 2020 2021 2022

Serum Unit Price (US$) 250 250 250 250

Volume Growth N/A 7.5 % 10% 30%

Sales Volume (units) 50,000 53,750 59,125 76,863

Total Direct Sales Revenue $12,500,000.00 $13,437,500.00 $14,781,250.00 $19,215,750.00

High-end anti aging products in the U.S., Prevage retails for about $175, and StriVectin for about $185. Japan and China: Based on the current pricing of Prevage and StriVectin, the company plans to price at more than $250.00 In 2018, the Freedonia Group estimated global cosmeceutical sales at about $5.8 billion and predicted a 7.4% average annual growth in the U.S. through 2020.

Business Plan 26 Non-medicated Item Estimated Sales

Financial Years Ending March 31 2019 2020 2021 2022

Capsule Unit Price (US$) 800 800 800 800

Volume Growth N/A 7.5 % 10% 30%

Sales Volume (units) 50,000 53,750 59,125 76,863

Total Direct Sales Revenue $40,000,000.00 $43,000,000.00 $47,300,000.00 $61,490,400.00

Business Plan 27 Cash Flow Analysis Assumptions

Fiscal Years Ending March 31 2019 2020 2021 2022

Total Revenue 1 $12,500,000.00 $13,437,500.00 $14,781,250.00 $19,215,750.00

2 $40,000,000.00 $43,000,000.00 $47,300,000.00 $61,490,400.00

Sub Total $52,500,000.00 $56,437,500.00 $62,081,250.00 $80,706,150.00

Cost of Sales (20% of Sales) 10500000 112 875 0 0 12416250 16141230

Marketing Expenses (2% of Sales) 1050000 112 875 0 1241625 1614123

Operating Expenses (4% of Sales) 2100000 2257500 2483250 3228246

Working Capital (10% of Sales) 5250000 5643750 6208125 8070615

Net Profit (24% of Sales) $12,600,000 $13,545,000 $14,899,500 $19,369,476

Business Plan 28 VVIP Medical Tour Estimated Sales

Fiscal Years Ending March 31 2019 2020 2021 2022

Unit Price (US$) $2,000,000.00 $2,000,000.00 $2,000,000.00 $2,000,000.00

Volume Growth N/A 10% 20% 30%

Sales Volume (Units) 100 110 132 172

Total Sales Revenue $200,000,000.00 $220,000,000.00 $264,000,000.00 $344,000,000.00

Cost of Sales (20% of Sales) $40,000,000.00 $44,000,000.00 $52,800,000.00 $68,800,000.00

Working Capital Tax / Operation Cost / $120,000,000.00 $132,000,000.00 $158,400,000.00 $206,400,000.00 Marketing Cost (60% of Sales)

Net Profit (20% of Sales) $40,000,000.00 $44,000,000.00 $52,800,000.00 $68,800,000.00

Business Plan 29 Company & Defytime Singapore Brand Structure

Equity Major Share Holder Equity Equity Pay License Fee Investment 51% Investment Investment

DefyAging Defytime Science Alternatif NZ Ltd New Zealand New Zealand New Zealand (DDC) Dermal Base PL

Local Sales R&D Center Clinic Center Corporation (Joint Venture)

Japan China USA

Business Plan 30 Proposed Summary Terms Investment: 19 Million USD

Summary Terms Description Target Investors from overseas 19 million USD The terms for the investment include receiving 30% of Defytime Singapore The entire business will operate with Defytime NZ capital of 19 million USD by purchasing or investing for the corporations shown in the Company & Brand Structure diagram. The business model for R&D and IPO will commence with the primary investment. Defytime Singapore HQ Shareholders Bill Andrews 20% Jonathan Greenwood 40% Investors 30% Others 10% Defytime Singapore A company targeted to be listed in the stock market (the target company for value maximization) Backdoor listing by securing the capital, or direct listing after 3~5 years If backdoor listing possible share premium realization through continuous R&D If direct listing: attracts large scale funds (attracting institutional and general investment when IPO) Sierra Sciences LLC Know how and patient management under the supervision of Dr. Bill Materials research and drug development, strategic management of intellectual property Deftime Science Drug Design Company Promotes new drug development based on Sierra Sciences’ findings Development of new drugs and health foods Defytime NZ Dermal related new product development and sales company management (Defytime Holdings’ subsidiary) Performs the role of a cash-cow Alternatif NZ Ltd Dermal Production Base Defytime Japan Regional sales or marketing subsidiary corporations Defytime China Attract investors with marketing skills and financing capacity in their region Defytime Korea (Joint Venture established) Management and control through sales licenses

Business Plan 31 Company Structure

Name of Company Defytime Limited (HQ)

CEO Jonathan Greenwood

Capital $500,000.00

Sale $500,000.00

Products Defytime Facial Serum, Mask Patch, Nasal Spray

Employees 8

Place New Zealand, Singapore, Hong Kong

Email [email protected], [email protected]

Website www.defytime.com

Name of Company Share Holder Relationship Number of Shares

Defytime Holdings Limited Jonathan Greenwood CEO 70

Business Plan 32 Contracts

Business Plan 33 Thank you

www.defytime.com