FACULTY PROFILE

1. Name: Dr. Santosh K. Upadhyay

2. Designation: Assistant Professor

3. Qualification: Ph.D. (CSIR-IGIB Delhi) Post-Doctoral Research (Tumor Virology, UPENN-Philadelphia, USA) Post-Doctoral Research (Anti-Cancer Therapeutics, RPCI-Buffalo, USA)

4. Area of Specialization/Research field: Molecular Bioprospecting for Human-health; Infection Biology; Cancer Biology

5. Awards/Recognitions:  Post-Doctoral Research Fellowships (National Institute of Health (NIH)-USA @ University of Pennsylvania, School of Medicine – Philadelphia (PA)).  Post-Doctoral Research Fellowships (National Institute of Health (NIH)- -USA @ Roswell Park Cancer Institute-Buffalo (NY)).  International Society for Human and Animal Mycology (ISHAM) award 2008.  Qualified National Eligibility Test (UGC-CSIR) for Junior Research Fellowship (year 2003 and 2004).  Qualified National Eligibility Test (Indian Council for Medical Research (ICMR)) for Junior Research Fellowship (year 2003).  Qualified Graduate Aptitude Test for Engineering (GATE) (conducted by Indian Institute of Technology, year 2003). Awards/recognition to research scholars:

 Ph.D. Scholar Ms. Ankita Tripathi received Young Scientist Award at International conference, ICEFN & SEM-2019, Organized by Nanoscience and Nanotechnology Centre, Kumaun University (April 2019). Also got selected for DST-INSPIRE fellowship (2017).

 Ph.D. Scholar Ms. Rekha Gahtori received Young Scientist Award in Annual meeting of Council of Science and Technology (March 2018). Also got selected for ICMR-SRF (2019).

 Ph.D. Scholar Ms. Nidhi Negi received Young Scientist Award in Annual meeting of Uttarakhand Council of Science and Technology (March 2018).

 Ph.D. Scholar Mr. Ashutosh Paliwal received Certificate of Appreciation, from Faculty of Science, Kumaun University Nainital, for research in Biotechnology (National Science Day, 28 Feb. 2017).

6. Number of Research projects: i) Completed S. Title of the project Funding Agency Amount(Rs.) Year N. (From-To) Development of reporter systems for 1 screening of anti-metastatic and drug- Kumaun Univ. (UGC) - 1.25 Lacs 2016-2017 resensitizing phyto-chemicals from Minor Res. Project under ‘Innovative Res. Uttarakhand-flora Activities Scheme’

ii) On-going S. Title of the project Funding Agency Amount Date of Expected N. Commencement date of completion To establish a DNA-barcoding 1 and chemotaxonomy empowered National Mission herbarium of lichen-species of on Himalayan Studies (NMHS), Uttarakhand-Himalaya and 2018 2021 Ministry 60.66 development of a resource group of Environment, Lacs for conservation and Forest & Climate characterization of lichen- Change biodiversity (MoEF&CC)

2 DNA-barcoding of ethno- 2020 2021 medicinal and high-value plants 9.97 of Uttarakhand Himalaya and assessment of anti-inflammatory DIBER (DRDO) Lacs nutraceutical potential of selected phyto-extracts

iii) Others S. Title Agency Amt.(INR) Period N. 1. Lead the inter-departmental team of Rashtriya Uchchatar 2.27 Cr 2015 researchers at Kumaun University in Sikshya Abhiyan (Granted to onwards drafting the proposal for ‘Establishing (RUSA) Kumaun Cancer biology program at Kumaun University) University’.

7. Number of Ph. D candidates successfully completed: Yet to complete

8. Number of Ph. D candidates currently working: 4

9. Publications: i) Book Chapters: 1. S. K. Upadhyay, R. C. Rai, R. Gehtori, A. Paliwal, P. Gautam, P. Joshi (2017). Drug Resistance in Cancer; in: Drug Resistance in Bacteria, Fungi, Malaria, and Cancer; Springer, USA (ISBN 978-3-319-48682-6). 2. P. J. Bhetariya, N. Sharma, P. Singh, P. Tripathi, S.K. Upadhyay, P. Gautam (2017). Drug resistance in human fungal pathogens against azole drugs; in: Drug Resistance in Bacteria, Fungi, Malaria, and Cancer; Springer, USA (ISBN 978-3-319-48682-6). 3. T. Dogra, L. Mahajan, S.K. Upadhyay, P. Gautam (2016). Human Pathogenic fungi and their Survival Mechanisms in the host; in: Industrial Microbiology; Nova Publications, USA (ISBN 978-1-63484-491-8). 4. L. Mahajan, S.K. Upadhyay, A. Archana, P. Gautam (2016). Gut Microbiota and human health; in: Industrial Microbiology; Nova Publications, USA (ISBN 978-1-63484-491- 8). 5. R. Joshi, T. S. Bisht, L. Mahajan, P. Gautam, A. Verone-Boyle, S.K. Upadhyay (2016). Use of Microbes in the Production of Vaccines; in: Industrial Microbiology; Nova Publications, USA (ISBN 978-1-63484-491-8). 6. S.K. Upadhyay, H. C. Jha, A. Saha, E.S. Robertson (2012). Lymphocryptoviruses: EBV and Its Role in Human Cancer. Cancer Associated Viruses, 1st edn. Springer. ii) Research Articles published in journals

1. H. C. Jha, Z. Sun, S. K. Upadhyay, D.W. El-Naccache, R.K. Singh, S.K. Sahu and E. S. Robertson (2016). KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation. PLOS Pathogens; DOI:10.1371/journal.ppat.1005801 (I.F.=7.6). 2. P. Gautam, D. Mushahary, W. Hassan, S.K. Upadhyay, T. Madan, R. Sirdeshmukh, C. S. Sundaram, P. U. Sarma (2016). In-depth 2-DE reference map of Aspergillus fumigatus and its proteomic profiling on exposure to itraconazole. Journal of Medical Microbiology, 54(5):524-36. (I.F.=2.3) 3. A. Saha, H. C. Jha, S.K. Upadhyay, E. S. Robertson (2015). Epigenetic silencing of tumor suppressor genes during in vitro Epstein–Barr virus infection. PNAS, 112(37):E5199- 207. (I.F.=9.7) 4. S.K. Upadhyay*, A. Verone*, S. Shoemaker , M. Qin, S. Liu, M. Campbell and P. A.

Hershberger (2013). 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) Signaling Capacity and the Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer (NSCLC): Implications for Use of 1,25(OH)2D3 in NSCLC Treatment. Cancers, 5: 1504-1521. PMID 24217116). *Equal contribution (I.F.~3.0) 5. S.K. Upadhyay*, H. C. Jha*, M. P. Aj, J. Lu, Q. Cai, A. Saha, E. S. Robertson (2013). H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J. Virol. 87(9):5255-69 (PMID 23449797). *Equal contribution (I.F.=5.1) 6. A. Saha, J. Lu, L. Morizur, S.K. Upadhyay, M. Prasad, E.S. Robertson (2012). E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells. PLoS Pathog. 8 (3): e1002573. (I.F.=7.6) 7. Q. Cai, B. Xiao, H. Si, A. Cervini, J. Gao, J. Lu, S.K. Upadhyay, S.C. Verma, E.S. Robertson (2012). Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation. PLoS Pathog. 8 (3): e1002566. (I.F.=7.6) 8. A. Saha, S. Halder, S.K. Upadhyay, J. Lu, P. Kumar, M. Murakami, Q. Cai, E.S. Robertson (2011). Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathog. 7(2):e1001275. (I.F.=7.6) 9. S.K. Upadhyay, P. Gautam, H. Pandit, Y. Singh, S.F. Basir, T. Madan (2011). Identification of Fibrinogen-binding proteins of Aspergillus fumigatus using proteomic approach. Mycopathologia. (PMID: 21870122). (I.F.=1.5) 10. S.K. Upadhyay*, P. Gautam *, W. Hassan, T. Madan, R. Sirdeshmukh, C.S. Sundaram, W.N. Gade, S.F. Basir, Y. Singh, P.U. Sarma (2011). Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin. Mycopathologia. 172(5):331-46. *Equal contribution (I.F.=1.5) 11. S.K. Upadhyay, L. Mahajan, Y. Singh, S. F. Basir, T. Madan (2009). Identification and characterization of a laminin binding protein of Aspergillus fumigatus: Extracellular thaumatin domain protein (AfCalAp). Journal of Medical Microbiology. 58(Pt 6):714- 22. (I.F.=2.3) 12. S.K. Upadhyay, J. Shankar, Y. Singh, S. F. Basir, T. Madan, P. U. Sharma (2009). Expressed sequence tags of Aspergillus fumigatus: Extension of catalogue and their evaluation as putative drug targets and/or diagnostic markers. Indian Journal of clinical biochemistry (Springerlink Journal) 24 (2) 131-136. 13. S.K. Upadhyay, S. F. Basir, T. Madan (2008). Characterization of cell wall Galactomannoprotein (Mp1) as a potential adhesin of Aspergillus fumigatus. The Journal of Allergy and Clinical Immunology. 121(2): S14. 14. J. Shankar, S.K. Upadhyay, S. Gupta, S. F. Basir, P. U. Sharma, T. Madan (2008). Global gene expression profile of Aspergillus fumigatus conidia during interaction with murine macrophage. The Journal of Allergy and Clinical Immunology. 121(2): S134.

iii) Papers presented in Conferences/Seminars

1. R. Gahtori, A. Paliwal, R. Anand, Y. Joshi, P. Joshi, L. M. Tewari, S.K. Upadhyay (2019). Studies on Lichen Biodiversity in Uttarakhand. National Conference SUTBC-January 06, 2019

2. A. Paliwal, R. Gahtori, N. Negi, G. Chand, P. Joshi and S.K. Upadhyay (2019). A survey of studies on phytomedicinal potential of lichens. National Conference SUTBC- January 2019

3. R. Gahtori, A. Paliwal, N. Negi, R. Anand, G. Chand, Y. Joshi, P. Joshi and S.K. Upadhyay (2019). Promoting the Lichen trade and conservation in Uttarakhand through facilitating precise species identification. International Conference ACMAP-2019, scheduled in February-March 2019

4. R. Gahtori, A. H. Tripathi, N. Negi, P. Joshi, S.K. Upadhyay (2018). “Molecular systematic identification and anti-bacterial activities of Nyctanthes and Perilla plant- extracts isolated from Kumaun region of Uttarakhand” 12th Uttarakhand state council for science & Technology (UCOST), Dehradun.

5. R. Gahtori, N. Negi, A. Paliwal, G. Chand, P. Joshi, S.K. Upadhyay (2018). “Molecular identification by DNA barcoding and assessment of the anti-oxidative and anti- bacterial activities of Nyctanthes arbo-tristis” 4th India International Science festival (IISF), Lucknow.

6. A Paliwal, R. Gahtori, N. Negi, P. Joshi, S.K. Upadhyay (2018) “Elucidation of anti- oxidative and anti-microbial potentials of alcoholic leaf-extracts of Cissampelos pariera: A traditional phytomedicinal plant in Uttarakhand” 4th India International Science festival (IISF), Lucknow.

7. S.K. Upadhyay *, A. Verone*, S. Shoemaker, M. Qin, S. Liu, M. Campbell and P. A. Hershberger. 2013. Vitamin D Signaling Favors Epithelial Phenotype in Non-small Cell Lung Cancers. Invited talk in International conference, 'Recent Advances in Cancer Prevention and Therapeutics (RACPT-2013)'. Central university of Gujarat, Gandhinagar November 19-20, 2013.

8. H. C. Jha, S. K. Upadhyay, A. Saha, Q. Cai, S. Banerjee, J. Lu, M. P. Aj, E. S. Robertson. EBNA3C mediated stabilization of aurora kinase B contributes to oncogenesis. 'International congress on oncogenic herpesviruses and associated diseases'. Philadelphia, Pennsylvania, USA August 1-4, 2012. 9. S. Canfield, H.C. Jha, S. K. Upadhyay, M. Shirley, E.S. Robertson. Helicobacter pylori facilitates EBV infection of gastric cancer cell line. 6th Annual conference of GI and Ball diseases, UPENN Medical School, 2012.

10. S. K. Upadhyay*, P. Gautam*, W. Hassan, T. Madan, R. Sirdeshmukh, C. S. Sundaram, W. N. Gade, S. F. Basir, P. U. Sarma. Studies on molecular mechanisms of amphotericin B and artemisinin against Aspergillus fumigatus using transcriptomic and proteomic approach. 5th AOHUPO (Asia Oceania Human Proteome Organization) International conference held from 21st-25th Feb 2010 at Hyderabad, India. *Equal contribution

11. S.K. Upadhyay, S.F. Basir, T. Madan. “Identifying anchors of menacing mold: extracellular thaumatin domain protein characterized as a potential adhesin of Aspergillus fumigatus”, Poster presented in 3rd Advances against Aspergillosis (International) conference (January 16-19, 2008 Miami Beach, Florida), organized by University of California, San Diego School of Medicine.

12. S. K. Upadhyay, S. F. Basir, P. U. Sharma, T. Madan. 2007. Characterization of extracellular thaumatin domain protein as a potential adhesin of Aspergillus fumigatus. 33rd Indian Immunology Society Conference, "Current Trends & Developments in Immunology" (28th January, 2007 - 31st January, 2007).

13. J. Shankar, S.K. Upadhyay, S.F. Basir. T. Madan, P.U. Sarma. “A novel antigen of Aspergillus fumigatus, showing homology with thiamine biosynthesis protein”, Poster presented in a National conference, ‘Biotech-2004’ (May 2004, Delhi, India). iv) Review articles published in journals:

1. A. Paliwal, R. Gahtori, A. Kumari, Negi N., Chand G., Joshi P., Tewari L.M., Joshi Y. and S.K. Upadhyay (2018). Applications and roles of Lichens in the conservation of Himalayan environment. ENVIS Bulletin Himalayan Ecology 26:47-52. 2. A. Tripathi, R. Gahtori, N. Negi, A. Paliwal, P. Joshi and S.K. Upadhyay (2016). Epithelial-Mesenchymal Transition (EMT), Cancer Progression and Role of Aromatase. J Chem Eng Chem Res. 3(11): 1067-1074. 3. A. Srivatsan, J. R. Missert, S.K. Upadhyay and R. K. Pandey (2015). Porphyrin-based photosensitizers and the corresponding multifunctional nanoplatforms for cancer- imaging and phototherapy. J. Porphyrins Phthalocyanines, 19: 1–26. (I.F.=1.4)

10. Conference/Seminar organized:

 Organized a National workshop (as Convener) on ‘Hands-on training on Classical and Molecular methods of Lichen-identification’ at the Dept. of Biotechnology, Kumaun Uni. Campus, Bhimtal (Uttarakhand), Sponsored by NMHS (MoEF&CC) and Uttarakhand Council for Biotechnology (UCB); 12-14 March 2020.  Organized a National workshop (as Convener) on ‘Lichen Identification and Conservation’ at (Uttarakhand), Sponsored by NMHS (MoEF&CC); 27 December 2018.  Organized Lecture (as Convener) of Dr. D.K. Upreti, FNASc, renowned Lichenologist, at the Department of Botany, Kumaun University Nainital, on ‘Introduction to Lichens’ Aug. 2018.  Member of organizing committee: International conference ICEFN&SEM-2019; Kumaun Uni. Nainital; 24-26 May, 2019.  Member of organizing committee: International conference ICEFN-2016; Kumaun Uni. Nainital; March 27-29, 2016.  Member of organizing committee: ‘Annual Bioinformatics Coordinators’ meeting’, Dept of Biotech. Kumaun Uni. Campus Bhimtal; March 03-04, 2016.  Member of organizing committee: ‘National Seminar NSSAPPE-2017’, Dept. of Botany, DSB Campus, Kumaun Uni. Nainital; March 27-28, 2017.

11. Academic/Administrative positions held

. Member of University Animal Ethics Committee, Kumaun University Nainital . Member of Institutional Biosafety Committee (IBS), Kumaun University Nainital. . Member of Departmental Anti-ragging cell. . Member of Departmental Admission committee. . Member of Departmental women cell. . Contributed in setting-up research collaboration between Kumaun University and Cell Stress Biology Lab.-Roswell Park Cancer Institute Buffalo (USA) for Cancer Research. . Member of flying squad for Uttarakhand Technical University. . Served as ‘Radiation Safety Officer’ for more than 2 years (2010-2012): Tumor Virology lab., Dept. of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. . Supervision of the Aspergillosis ELISA facility of CSIR-IGIB for more than 3 years (2004-2007).

12. Membership to professional Organization/Associations:

. Member ‘International Association of Lichenology (IAL)’. . Affiliate Member (International) Microbiology Society. . Life member of Indian Association for Cancer Research (IACR). . Life member of Indian Science Congress Association (ISCA). . Life time member of Indian Immunology Society (IIS). . Has been member of American Society for Microbiology (ASM). . Has been Affiliate Junior Member of European Academy of Allergology and Clinical Immunology (EAACI). . Has been Doctoral/post- doctoral in training member of American Academy of Allergy Asthma and Immunology (AAAAI).

13. Reviewer/Examiner Duties

. In the reviewers’ panel of reputed journals viz. PLOS ONE, RSC Advances, J Pharmacy and Pharmacology, Cancer Review, Tumor and Microenvironment etc. . In the PhD thesis examiners panel of The University of KwaZulu-Natal (UKZN) . In the Project Reviewers’ panel of DST-SERB . In the examiners’ panel of MJP Rohilkhand University, Uttarakhand Technical University, HNB Garhwal University, B.T. Kumaun Institute of Technology Dwarahat and G.B. Pant University of Agriculture and Technology, Pantnagar. . Have been serving as External and Internal examiner for practical examinations conducted by Kumaun University for Undergraduate and Post-graduate courses related to Life Sciences.

(Dr. Santosh K. Upadhyay)