ISIC-2016 Abstract book

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Abstract Book Of IXth International Interdisciplinary Scientific Conference Of Young Scientists And Medical Students

«Actual Problems Of Clinical And Theoretical Medicine»

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BIOMEDICAL SCIENCES

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Aleksandrova С., Shaposhnik S. AMYLOCLASTIC POWER OF BUCCAL EPITHELIUM CELLS AND THE INCIDENCE OF RESPIRATORY DISEASE AMONG THE CHILDREN OF SCHOOL AGE Research advisor: Dzhameyev V., Candidate of Biological Sciences Department of medical biology, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Introduction. Sometimes I. Healthy children with the during the treatment of children, are lowest incidence of disease; needlessly used medicines that II. Children with a high reduce immune system and body's incidence of the disease; resistance, instead of contributing to III. Students with a high the rapid recovery. Therefore, it is incidence of the disease who recently necessary to use current diagnostic had a disease. measures allowing accurately Each group included three age determining the causes of the subgroups: 8-10; 11-13 and 14-16 disease and prescribe appropriate years. treatment. Sampling was carried out from 9 One of the modern non- to 10 AM fasting by massaging the traumatic diagnostic methods of inner surface of the cheek with a respiratory diseases is the cotton swab. Amylase activity of determination of the buccal buccal epithelial cells was epithelium enzyme activity. After all, determined by the colorimetric the epithelium of the mucous Wohlgemuth method. membrane is a major factor of the Results. The research has local immunity. shown that healthy children have The aim of our work is to study normal level of amyloclastic power the relationship between amylase of buccal epithelial cells. However, activity of buccal epithelial cells and children who often suffer from the morbidity rate of respiratory respiratory diseases, have the infections among the pupils. substantially reduced rate. The Material and methods. The lowest level of amyloclastic power object of the research is buccal was found among children, who had swabs taken from children aged 8- recently been ill. Among children 16, who often suffer from acute who are often sick, but during the respiratory infections. 46 students of experiment were healthy, in two age the Kharkiv Technological Lyceum groups from 8 to 13 years amylase №9 were investigated. They were activity was significantly lower than divided into three groups: normal, but significantly higher than among children who have been

4 ISIC-2016 Abstract book recovered. Among older children the child, which is probably related though, this value was within the to the level of the development of normal range. mucous membrane of the oral cavity. The conclusion. Thus, these 3) The most vulnerable to data suggest the following respiratory diseases were the conclusions. children of 11-13 years. 1) The incidence and rate of 4) Determination of susceptibility to infectious lesions of amyloclastic power of buccal oral cavity depends on the level of epithelium may be recommended for amyloclastic power of buccal wide use in clinical and laboratory epithelium. practice for the diagnosis of 2) The degree of resistance of respiratory diseases and an the organism depends on the age of increased tendency towards them.

Anmalugsi Pius INTERRELATION BETWEEN SEROTONIN CONTENT IN CEREBELLUM AND REGIONS OF EMOTIOGENIC LIMBICOCORTICAL SYSTEM OF BRAIN IN THE SUBMISSIVE AND DOMINANT Research Advisor: PhD, Associate Professor Popova L. Department of Biochemistry Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Serotonin is purkinje cells and cerebella nuclea. believed to contribute significantly to Serotonin is critical for cerebella the mechanism of genetically development ans its normal function determined individual differences in in the matured state. aggressiveness. In men two forms The Aim: The investigation of have been described; impulsive and correlation between serotonin controlled ( in animals-spontaneous content in cerebellum and frontal and adaptive respectively ). cortex plus hippocampus in Impulsive aggression is observed in submissive and dominant male rats. patients with depression. Submissive Materials and Methods: Work rat can serve as an experimental was carried out on 24 male rats of model of depression. Dominant rat the young reproductive period. demonstrate adaptive aggression. Distribution of the animals into Anatomical and groups with alternative type of immunohistochemical studies shows behavior was made using a model of that the cerebellum is extensively emotion stress "sensory contact" enervated by serotoninergic fibers with some modifications. According and they modulate the firing rate of to results of the testing, the animals

5 ISIC-2016 Abstract book were divided into 3 groups; Strong positive correlations were dominant,balanced and submissive. revealed between serotonin content Serotonin content in brain regions in cerebellum and hippocampus, was determined by fluorometric between serotonin content in micromethod. cerebellum and frontal cortex in al Results: According to the investigated. results obtained the serotonin level Conclusion: The decrease of was significantly decreased in all serotonin content in all investigated investigated brain regions of rats brain regions in submissive rats with submissive behavior type indicates the importance of versus both balanced and dominant serotonin deficiency in the formation ones. In dominant animals versus submissive behavior type. The same balanced ones, the tendency to the direction of serotonin changes in the increase in serotonin content was the hippocampus, frontal cortex and observed. Our results supports the cerebellum, strong correlation assumption of Neumann I.D et al. between serotonin content in (2010) about a different role of cerebellum and frontal serotonin in adaptive form cortex/hippocampus of all behavior aggression such as social dominance type rats is evidence of cerebellum (activation of serotoninergic involving in the formation of neurotransmission) versus abnormal realization of submissive and forms of aggression (reduced dominant behavior types. serotoninergic neurotrnsmission).

Avilova O.V. METASTRUCTURE OF THE SPLEEN UNDER THE IMPACT OF TRYGLYCIDYL ETHER OF POLYOXYPROPYLENE TRIOL Research advisor: Tereshchenko A.O., professor, Kolisnik I.L., assistant professor Department of human anatomy, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. The polyethers, as The aim of the study was to widely used xenobiotics not only in investigate the structural features of manufacture but in everyday life, the spleen of rats under the impact of have huge influence on human's tryglycidyl ether of organism, that dictates the need for polyoxypropylene triol, that is thorough study of the impact of this related to the class of polyethers. chemicals on the spleen Materials and methods: The metastructure. morphological study was performed

6 ISIC-2016 Abstract book on white Wistar outbred rats, during mitochondria had a slightly 30 days to the animals was elongated oval shape and localized administered by mouth the chemical mainly in the perinuclear cytoplasm. substance - tryglycidyl ether of A significant number of polyoxypropylene triol in a dose of mitochondria contained a large 1\100 DL50 by a metal probe. number of cristas. Mitochondrial Changes were studied on paraffin membrane was partially destroyed. sections using conventional The granular endoplasmic reticulum histological and histochemical is well developed, but it's cisternas methods (hematoksylyn-eozin, are greatly expanded and formed a pikrofuksyn by Van Hizonu, Feulgen- system of fairly large vacuoles filled Rosenbeka reaction, Brush reaction, with сoarse-fibred substance of the Daniels reaction, and lipid medium density. There were staining on frozen sections by Sudan detected ribosomes on the III). membranes of the endoplasmic Results: it is established that reticulum but in a very small tryglycidyl ether of number. polyoxypropylene triol exposes Conclusions: our study had nuclei of reticular cells of the spleen revealed dystrophic and destructive acquire an elongated shape.The changes of intracellular membrane nuclear membrane is smooth, structures, that shows activity loosened. The chromatin in the form reparative processes reduction, of osmophilic lumps concentrated changes of cells bioenergy, that is along karyolemma and had a structurally proved by destruction of homogeneous structure. In the membranes and mytochondria's center of the nucleus formed zone of cristas. very low electron density. A few

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Berdikova Julia FEATURES OF PENETRATIVE ACTION OF BULLETS AT SHOTS FROM AN AIR RIFLE DEPENDING ON A DISTANCE OF SHOTS Research advisor: Prof. Olhovsky Vasily Alekseevich Kharkiv National Medical Iniversity Departament of Forensic Medicine, Medical Law

Actuality. It is known that the biological material (dry wood, linen general regularities of penetrative fabric, porous cardboard). action of the bullets which are let out Results. The report of results from air rifles is that most of experiment consisted in fixing of intensively she is shown at shots at a the maximum depth of penetration distance to 5 m if the weapon is worn of a bullet into the object at blind a little out, and to 5 m - on the worn- damages. Shots in a biodummies was out weapon. Penetrative action of revealed steadily high ability of bullets depends on their speed at the bullets at all distances of shots to 15 time of a meeting with a barrier and, m inclusive. Damages has been more, on the mechanism of action of presenting by blind bullet wounds a bullet. Most of the models from 3,5 cm to 8,4 cm in depth. pneumatic weapon are construct in Depth of damages of 5 cm is this way, to provide starting velocity characteristic at shots in an bullet 130-170 m / s. emphasis, and also of distances of 5 The aim. Analysis of cm, 10 cm and from 3 to 10 m penetrative ability of bullets of inclusive. "Diabolo-1" which are let out from Conclusions. Between the air rifle of "IZh-38" depending on distance of shots from the air rifle the distance shots. and depth of wound channels in Materials and methods. targets there is an inversely Research was conducted on an air proportional dependence: increase rifle of "IZh-38", cut, single shot, in the distance of shots, as a rule, it double-barreled, sports and mass, causes a decrease in the depth of the spring-piston, with the fluctuating wound channels by slowing down trunk. Also had been used bullets the speed of flight of bullets that, in "Diabolo-1", biodummies and not turn, leads to reduction of kinetic energy of bullets.

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Bibhu Charan Nayak, Santosh Acharya, Sanipini Swati SHORT TERM MEMORY: THE FEATURES OF REMEMBERING Kharkiv national medical university (department of Ukrainian language, principles of psychology and pedagogics) Kharkiv, Ukraine

In modern society people often technique which was provided to face the problem of information investigate the durability of working remembering. This stimulates us to memory in terms of the multistore use different types of our memory, model. The experiment was held at a especially short term memory the special laboratory. 24 students duration of which is, thus, of great involved in the assay were asked to importance. This fact makes the recall meaningless-three-consonants topicality of our research and causes syllables called trigrams, e. g. NDF, our goal: to find out the features of RAN, ITK etc. It was necessary to short term remembering. prevent repeating so testees were Memory is considered to be a told to count in 3 or 4 from a specific process of encoding, storage and accidental number until the light retrieval of different kinds of signal appeared. Then they had to information. It is well-known that recall trigrams after a time span of our memory can be considered as 3–18 sec. The test showed that the having three types: sensory, short amount of trigrams recalled term and long term memory. depended on the length of the time In sensory memory information interval. The students recalled 80% is being held for less than a second of information after 3 sec. but they after an item is perceived. Short term could not recall more than 10% of memory (or working memory) gives trigrams after 18 sec. delay. Such an opportunity to recall information results prove once more that for a period up to a minute without information can be recovered from repeating. The storage in these two short term memory only during a types of memory is strictly limited in short period of time (not more than a its duration in contrast to long term minute) and only if this information memory which can store larger is still important. quality of information which is Thus, short term memory is supposed to be unlimited. strictly limited in its duration in case In everyday life short term of rehearsal prevented and any delay memory is considered to be the most causes the lost of information from common. That is why its lasting has short term memory. We can also always been an object of different state that short term memory differs studies such as the Brown-Peterson greatly from long term one in its

9 ISIC-2016 Abstract book duration. Thus, we can state the human memory. existence of multistore model of

Boiko Kateryna Oleksandrivna, Terletska Evgenia Oleksandrivna THE IMPACT OF PHYSICAL PERFORMANCE ON THE QUALITY OF LIFE OF YOUNG PEOPLE Research advisor: Candidate of Medical Sciences Nazarko Natalia Mukolaivna Department of Physical Rehabilitation and Sports Medicine Bogomolets National Medical University Kyiv, Ukraine

Actuality: Individual physical questionnaire of the quality of life - fitness has a significant contribution SF-36 . in health formation, in the body's Results: Among the surveyed ability to effectively perform students there were 48,5% (percent) muscular work. But rapid civilization of students with reduced physical development has contributed to the performance, 19,1% - with average deterioration of the motor areas of physical performance and 32,4% - life through social problem number with increased physical one - lack of physical exercises. performance. General health of Comprehensive valuation of health is students with high level of physical based not only on objective data, but performance was significantly better also on the subjective perception by compared with students with man of psychological, emotional, reduced physical performance and social and economic aspects of life, was 54,5±1,7 and 48,6±2,0 points namely quality of life and physical respectively (p<0,05). performance. However, their Role functioning caused by relationship is insufficiently studied. emotional state significantly was the Aim: To study the relationship best of students with low and of the quality of life of young people average physical performance and with their level of physical amounted to 59,1±2,6 and 46,2±5,0 performance to motivat them for points respectively (p<0,05), self-correction and exercising. apparently because these students Materials and methods: 136 justified that physically less active, students of Bogomolets National but anyway their lives quite diverse Medical University, 21,8±0,3 years and their physical level are more old, were assessed by pulse value of than appropriate. standard (Patent UA 34351 A) and Physical functioning, role functioning

10 ISIC-2016 Abstract book due to physical condition, intensity of physical performance scaled for of pain, vitality, social function and general health and role functioning, mental health were not significantly due to emotional state, creating the different between these groups need to modify their physical activity (p>0,05). by developing individualized Conclusions: Quality of life of recommendations. young people depends on their level

Bеzega E. V. MITES – PATHOGENS EAR MANGE (OTODECTOSIS) Research advisor: Kulachenko Boris Vladimirovich Kharkiv National Medical University Department of Biology Kharkiv, Ukraine

Actuality. Ear mange garbage dumps of the city of (Otodectosis) is a widespread, acute Krasnograd, in the village of Gerbils or chronic course disease that cause and Pets whose owners have applied members of the family Psoroptidae, for examination to the veterinary of the genus Otodectes. Often the clinic. During the period of study causative agents of the disease are determined the sensitivity of the transmitted from animals to humans pathogen to high and low and Vice versa. It is of great practical temperatures, set the sensitivity of importance for medicine and the parasite to the action of encourages to study parasitic ivermectin. diseases of animals not only to Results of the study. Known protect your pet, but also cases of infection by mites is people. information on possible future It parasitizes in several months and disease of the host. causes inflammation of the outer and The aim. To study the middle ear, allergic skin reaction to otodectosis of the disease and its bites of parasite that is manifested danger to humans. by severe itching. Materials and methods. The Conclusions. Analyzing the work was conducted in the spring literature sources and the results of and autumn period 2014-2015. our research we can conclude: During this period, ticks were 1. The causative agent can be examined in animals that were transmitted from animals to man. homeless. We surveyed animals Cause itching, allergic reaction in the found in parks, on the streets and bites of ticks, inflammation.

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2. Mites of the genus Otodectes scrod lesions of the ears, external auditory was sensitive to ivermectin, high and canal and tympanic membrane, low temperatures. accompanied by itching, dermatitis 3. Ear mange is characterized by skin (otitis media).

Cherniakova A. M. THE ROLE OF S.AUREUS IN THE ETIOLOGICAL STRUCTURE OF INFECTED WOUNDS IN BURN PATIENTS Research advisor: Minukhin V.V., professor Microbiology, virology and immunology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The infected burn microorganism strains obtained wounds are of serious medical, social from the burn patients were isolated and economic value. 75% of all and investigated. Gram-positive deaths in the cases with severe burns microorganisms were found to be (more than 40 % of the total body more prevalent in burn wounds (135 surface area) are currently related to strains were isolated that is 57% of sepsis from burn wound infection or the total number of received other infection complications. pathogens) whereas Gram-negative The aim of the research. Find bacteria were found in 84 strains out the bacteriological profile of (35.5% of the total number of post-burn wound infections and to microorganisms). Candida fungi (18 determine the role of S. aureus in the strains -7.5%) were identified as etiology of infectious complications well. It was found that S.aureus was in burn patients treated at the the cause of infectious complications Kharkov Burn Center. development in 104 cases (44% of Materials and methods: the the total number of the obtained wound discharge from the studied microorganisms). This pathogen was patients served as material for associated with other agents in 6% investigation. Specimens were of cases (Pseudomonas aeruginosa-8 collected as wound swabs. The strains, Proteus mirabilis-3, Candida organisms were isolated and fungi–4). identified by standard Conclusions: Our findings microbiological methods. The confirm with the available data of obtained results were processed other authors, who noted using the statistical PC software. "prevalence" of Gram-positive flora Results: The study was carried and 2:1 growth ratio of S.aureus and out from 2007 to 2015 at the P.aeruginosa in blood cultures of the Kharkov Burn Center. 237 patients with burn sepsis. Disposal of

12 ISIC-2016 Abstract book these data is of practical value for complications occurrence in burn doctors and scientists for the patients, as well as carrying out and improvement and development of developing new treatment strategies. new drugs to prevent septic

Chirva A.V., Sokol E.N. STUDY OF THE EFFECT OF BACKGROUND COLOR AND FONT OF TEXT DOCUMENTS ON THE PROCESS OF ADAPTATION OF MEDICAL STUDENTS TO INTELLECTUAL LOADS Research Advisor: PhD, Associate Professor Marakushin D.I. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Introduction. using "Schulte Table", tests Paramount importance in the Münsterberg and Bourdon. Mental process of analytical and synthetic capacity and mental rate was afferentation of the space evaluated by the method Kraepelin. surrounding belongs to the visual Results and discussion. At the sensory system. For intelligent 1st stage we were using Münsterberg people, whose professional activity is and Bourdon methods a black font connected with the reading of a large on a white background. The level of number of text documents relevantly concentration divided students into is the efficiency of the visual 3 groups: 1st – high level of 35.6%; analyzer. 2-nd – medium – 55,2%; 3rd – low of The Aim: the goal of the study 9.2%. At the 2nd stage we were using was to determine the optimal a green font on a white background. background and font to enhance As a result, the level of concentration mental performance and the in all study groups was significantly efficiency of the visual analyzer in increased, and redistribution in the process of formation of adaptive groups in the direction of increasing reactions to intellectual exertion. the number of students with a high Materials and methods. The degree of concentration. At the 3d study was made among 69 students stage used a green background and of the 2nd course of medical red font (green is calming, red – University, has signed a voluntary activates). As a result, all indicators consent to perform this study. had increased, but especially its Mental stability, indicators of volume. By using "Schultz Tables" attention, the efficiency of visual the results of high concentration perception process was determined showed 48.3% of the subjects; the

13 ISIC-2016 Abstract book average is 46.8 %. At the 2nd stage Conclusion. The results of we were using purple and yellow these studies allow us to conclude font on a white background. Results about the influence of background significantly decreased and color and font of text documents on increased the task completion time, the indicators of attention errors appeared while working with (concentration, volume, the 4th and 5th cards that testified to distribution). Red font on a green the fatigue of visual perception in background and green font on a continuous operation with the white background improves the yellow font. Such association of process of distribution and colors has caused tension concentration. The optimal reactions mechanism of the differential to adjust and adapt to intellectual sensitivity of the visual analyzer. loads must correspond to the Only 37,3% of the students retained effective functioning of the visual high. sensory system.

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Dobrovolskaya E.M., Maryenko N.I. VARIANT ANATOMY OF THE LOBULES OF THE POSTERIOR LOBE OF THE HUMAN CEREBELLUM Research advisor: Stepanenko A.Yu., Associate Professor Kharkiv National Medical University Department of Histology, Cytology and Embryology Kharkiv, Ukraine

Actuality. The cerebellum is into two main branches, there is not one of the most important functional secondary branches. The first variant structures of the central nervous – one secondary branch leaves from system, which provides statics and the upper main branch. The second coordination, it is also involved in variant – one secondary branch cognitive processes, emotional state leaves from the lower main branch. regulation. Morphological changes of Third – one secondary branch leaves cerebellar lobules are found in many from the place of division of the main congenital and acquired diseases of trunk. Fourth – the first secondary the cerebellum, at various mental branch leaves from the upper main disorders. branch, the second secondary branch The aim. To investigate leaves from the lower main branch. individual variability and features of The fifth variant - upper main branch variant anatomy of the posterior lobe divides into three secondary of the cerebellum. branches. The sixth variant: Material and methods. secondary branches depart from the Research was conducted at the upper branch sequentially. The Kharkiv regional bureau of forensic seventh: upper branch generates one medicine on 230 cerebellums of branch, which is divided into people of both sexes, who died of proximal and distal branches. The causes unrelated to brain pathology, eighth variant – lower main branch 20-99 years old. divides into three secondary Results. The shape of lobules branches. The ninth variant: that form the posterior lobe of the secondary branches depart from the cerebellum is quite varied. lower branch sequentially. The tenth Differences of the structure of these variant: lower branch generates one lobules depend on the characteristics branch, which is divided into of the branching of the white matter, proximal and distal branches. The the number and location of the eleventh variant – the first secondary secondary branches. Variants of the branch leaves from the upper main structure of different lobules are branch, the second secondary branch similar to each other. Zero variant of leaves from the place of division of the structure – main trunk is divided the main trunk. The twelfth variant–

15 ISIC-2016 Abstract book the first secondary branch leaves lobules of the posterior cerebellar from the lower main branch, the lobe, namely white matter branching second secondary branch leaves features. 14 variants of white matter from the place of division of the main branching of the lobules can be trunk. The thirteenth variant – both identified. These variants occur with secondary branches leave from the varying frequency. Described place of separation of main trunk or variants of the shape of the secondary branch divides into two cerebellar lobules can be used as daughter branches. criteria standards of modern Conclusions. Thus, it was diagnostic imaging techniques for found that there is individual the diagnosis of various diseases of variability of the structure of the the CNS.

Dutchak S.R., Priadka T.M. MEDICINAL ANALGESIC AND ANTIPHLOGISTIC THERAPY WITH AN EXTRACT COMFREY Research advisor: Melnyk M.V., Candidate of Medical Sciences, docent Department of Medical and Biological Chemistry, IFNMU, Ivano-Frankivsk, Ukraine

Actuality.Comfrey known use be accessible, safe and biodegradable for the treatment of joints and search led to compositions based on healing of wounds in a variety of natural water-soluble polymers, dosage forms. The most important gelatin, polyvinyl alcohol and starch. compound that causes the most basic Results: Individuals have our pharmacological properties of drugs combination of biocompatible made from medicinal comfrey is polymers are effective and safe when allantoin. used as a means of stitching together The aim of the research. of lactic acid and zinc oxide, forming Prepare medicalpellicles with a complex capable of increasing the different ratios of pellicle-forming strength of the polymer pellicle. materials and introduced them Were selected the best value comfrey in the alcohol solution and components that yield a film that dry weight; studied the rapidly degrade (1-2 days) and long- physicochemical properties of the acting (7-10 days). pellicles of comfrey, their ability to Conclusions: The swell and output of active experiments showed that the substances. synthesized pellicle can be prolonged Materials and methods: The drug and allows it to maintain a need for pellicle-forming materials constant concentration of active

16 ISIC-2016 Abstract book ingredient allantoin over a longer will enable dynamic allocation time than one day. Study selection evaluate these substances of tannins with syntheticpellicle also synthetic drug pellicle.

S.R. Dutchak, T.M. Priadka MEDICINAL ANALGESIC AND ANTIPHLOGISTIC THERAPY WITH AN EXTRACT COMFREY Supervisor: Candidate of Medical Sciences, docent M.V. Melnyk Ivano-Frankivsk National Medical University Department of Medical and Biological Chemistry

Background. Comfrey known their ability to swell and output of use for the treatment of joints and active substances. healing of wounds in a variety of Materials and methods. The dosage forms. The most important need for pellicle-forming materials compound that causes the most basic be accessible, safe and biodegradable pharmacological properties of drugs search led to compositions based on made from medicinal comfrey is natural water-soluble polymers, allantoin. Results of clinical studies gelatin, polyvinyl alcohol and starch. have shown that it promotes the The obtained results. growth of new fibroblasts - cells Individuals have our combination of from which bones are built. It is biocompatible polymers are effective established that the substance and safe when used as a means of contributes to the formation and stitching together of lactic acid and renewal of bone and connective zinc oxide, forming a complex tissue. capable of increasing the strength of Medicinal pellicles are known the polymer pellicle. Were selected for their properties as long-acting the best value components that yield drugs have advantages over a film that rapidly degrade (1-2 days) traditional methods of and long-acting (7-10 days). administration of drugs. Conclusions. The experiments The purpose and objectives showed that the synthesized pellicle of the study. Prepare medical can be prolonged drug and allows it pellicles with different ratios of to maintain a constant concentration pellicle-forming materials and of active ingredient allantoin over a introduced them comfrey in the longer time than one day. Study alcohol solution and dry weight; selection tannins with synthetic studied the physicochemical pellicle also will enable dynamic properties of the pellicles of comfrey, allocation evaluate these substances of synthetic drug pellicle.

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Zupanets I.A.1, Karnaukh E.V.2, Filyanin S.I.2 BODY MASS INDEX AS ONE OF THE MARKERS OF METABOLIC PROCESSES IN BIOEQUIVALENCE STUDIES 1National University of Pharmacy 2Kharkiv National Medical University (Departmemt of Pharmacology and medical prescription)

Kharkiv, UkraineResults . In healthy volunteers Actuality. Today in Ukraine with low BMI the maximum there are about 14 thousand drugs, concentration of test drug (Cmax) about 90% of which are generics. was more than 21% from healthy The most convincing method to volunteers with high and medium confirm their interchangeability are BMI. bioequivalence studies. In healthy volunteers with high In this article we study the BMI (greater than 26,5) - time to influence of the body mass index maximum concentration of the test (BMI) on the pharmacokinetic drug (Tmax) was higher by 27% properties of drugs. than in healthy volunteers with Materials and methods. medium and low levels of BMI. Retrospective analysis of 15 Conclusion. The study found bioequivalence studies carried out in that at the planning stage of Clinical and Diagnostics Center of bioequivalence study we should take National University of Pharmacy in into account the probability of the period from 2005 to 2015. There influence of different BMI types on are 3 types of BMI: Low - 18,5-20,5; the pharmacokinetic parameters; the Medium - 20,6-26,5; High - 26,6-30. medium level of BMI is optimal, Aim. The study of the impact of because it allows the greatest BMI on the pharmacokinetic effectiveness of the results of the parameters of the drugs. bioequivalence studies.

Ganizade N.D., Sheyan D.N., Liutenko M.A., Topchyi S.V. INFLUENCE OF THE ELECTROMAGNETIC RADIATION ON THE CENTRAL NERVOUS SYSTEM Department of Human Anatomy, Kharkiv National Medical University, Kharkiv, Ukrainе

Actuality. Rapid development mankind about twenty years ago, of telecommunications and computer proceeds and now. The level of technologies which have overflowed electromagnetic radiations (EMR)

18 ISIC-2016 Abstract book brings powerful contribution into Experiments were spent daily and environmental contamination. First automatically by device EMR with of all, this problem concerns frequency of 1800-2100 MHz especially vulnerable members of the (frequency of modern mobile society who are most subjected to phones). It was disconnected once a influence of fields - children and day, during feeding and caring of teenagers. In modern informational animals contained in vivarium’s world, the basis of an environment of conditions. the child is occupied with mobile Results. Rats lost weight (45- devices, gadgets with various kinds 60 g at the radiated group in of access to the Internet, Wi-Fi comparison with 92-95 g at the routers etc. In the literature, control one), growth (a difference of accessible to us, we have found out 2-3 cm), were inactive, with the low some works devoted to the given appetite, the raised thirst was theme in which frequency observed. Distinctions between corresponding to given devices was brains in the weight (1, 65-2, 58 g at used. In this connection we consider radiated and 3,97-4,05 g in normal) that all-round scientific researches were observed. The functional allowing to prove the change of characteristics of defeat CNS became principles of criteria of safety are appreciable: aggression display, necessary for children, taking into unsteadiness, pendular movements account prospects of development of by a head, the slow reaction to communications. irritant influence. The aim to study influence the Conclusions. It is necessary to EMR on the nervous system. develop ecological recommendations Materials and methods. about influence EMR on children. We Experiment was made on 20 rats established pathological influence aged of 20 days that corresponds to the EMR on a children's organism, in age of the person from 6 till 7 years. particular on CNS. We recommend Rats have been divided into excluding the influence of the EMR experimental and control groups. on children for prevention the Duration of an experimental part in development of possible pathologies. each group was 30-50 days.

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Gubin N., Pogodina E., Drobotova K., Yarmak I. FORENSIC-MEDICAL EVALUATIONS DAMAGESOF RESPIRATORY SYSTEM WITH ACUTE RESPIRATORY FAILURE Research Advisor: MD, Professor Olhovskiy V. Department of Forensic Medicine and Medical Law Kharkiv National Medical University Kharkiv, Ukraine

Actuality. In specialized medical assessment, blunt trauma of literature and legal documents in lung with occurrence sufficient level, summation of hemopneumothorax and ARI, features of acute posttraumatic especially when not injured ribs. At respiratory insufficiency (ARI), examinations take place cases, which must be used for its forensic- connected with change the severity medical evaluation. Not defined, in level of physical injuries, established which the severity level of ARI, during the initial and follow-up forensic experts in case of damages examination. Experts at carrying out of respiratory system (DRS), such examinations in his conclusions affections of larynx, trachea, lungs, refer to paragraph 2.1.2 "Rules of must evaluate this injury as determining the severity level of dangerous for life. It should be noted physical injuries" and evaluate chest that in different literature, the injury and its organs as severe authors suggest different laboratory physical injury as dangerous for a and instrumental parameters that life. Then, during repeated characterize the signs and severity of examinations previously estimated ARI. severe level of physical injuries, Purpose. Content analysis changed to simple level of physical expert cases of injuries respiratory injury. The experts refer to the system, which complicated of ARI, absence of ARI as a dangerous for a for identify ways of improving life events, in accordance with forensic-medical diagnostics. paragraph 2.1.3 "o" "Rules ...". Material and methods. We analyzed Based on a thorough analysis of the 87 conclusions of forensic- contemporary literature, devoted to medical examinations connected the diagnosis of emergency with DRS form archives of Kharkov conditions, we selected ARI criteria, regional bureau of forensic medical which can be used to improve the examination from 2007-2015 years. objectification and estimation at Results and discussion. The forensic-medical examination. analysis of the observations showed Depending on the severity level of that the greatest difficulties in the ARI, we have identified and grouped experts are the cases of forensic- 14 clinical, instrumental, laboratory

20 ISIC-2016 Abstract book parameters, which include the especially with the emergence of ARI definition of partial oxygen tension has some difficulties. Usage at and carbon dioxide in arterial blood, forensic-medical examination of its acidity et al., which is quite well-defined clinical, instrumental objective and characterize four and laboratory signs of ARI, increase degrees of severity level ARI. objectification of expert conclusion Conclusions. Forensic-medical and help avoid mistakes at evaluation of injuries DRS, which determining the severity level of belongs to dangerous for a life, physical injuries.

Hladkykh F. V., Stepaniuk N. H., Sokyrko M. V. THE EFFECT OF VINBORON ON THE EXPRESSION PROCESSES OF APOPTOSIS IN GASTRIC MUSOCA WITH IBUPROFEN-INDUCED GASTROPATHY IN RATS Vinnitsa National Pirogov Memorial medical University (Department of pharmacology) Vinnitsa, Ukraine

Introduction. Nonsteroidal simulated adjuvant arthritis (AA) in anti-inflammatory drugs (NSAIDs) is rats. the most popular for the treatment of Methods & materials. To a variety of diseases. However, their assess the pathological changes in use can cause serious complications gastric mucosa studied experimental in the gastrointestinal tract. To material produced from AA rats after identify the specific lesions of the administration of ibuprofen and its stomach, associated with the use of combination with vinboron. To NSAIDs in 1986 S.H. Roth suggested examine apoptosis in caspase-3 the term "NSAID gastropathy." From (CPP32) was selected as a marker. the literature it is known that one of The estimation of the expression of the mechanisms ulcerogenic actions caspase-3 in the formulations of the NSAID stands activation of apoptosis gastric mucosa at 400-fold of epithelial cells of the gastric magnification in similar sections mucosa. using a semiquantitative scale color The aim: to rate according intensity evaluation. immunohistochemical study effect of Results. The study showed ibuprofen (218 mg/kg) and its that in the monotherapy group combination with vinboron (11 ibuprofen number of positively mg/kg) on the apoptosis of epithelial stained cells was more than 60%, cells of gastric mucosa in the which was significantly (p<0,05) higher than in intact rats and Group

21 ISIC-2016 Abstract book combined use of ibuprofen and Vinboron gastroprotective effect vinboron in which the figure was 10- manifests inhibition of apoptosis 30% . process, as evidenced by a decrease Conclusions. Results of the in caspase-3 expression in the study indicate the ability of cytoplasm of epithelial cells of the ibuprofen act inducer of apoptosis of stomach. epithelial cells of the gastric mucosa.

Holnik Yana, A.V. Morozov COMPENSATION OF CARBOHYDRATE METABOLISM AS A FUNCTION OF PHYSICAL ACTIVITY OF CHILDREN WITH DIABETES MELLITUS Kharkiv National Medical University D. Alpern pathologic physiology department

Actuality. Currently the survey the people with DM and level treatment of diabetes is defenition of PA with using IPAS. characterized by the inability of full Children were devided to the groups compensation of the disease using depending on the level of HbA1c with only insulin, even with using the new recommendation ESPAD (2009)- 1 forms. Approaches to the diet gr.HbA1<7,5% (n=7); 2 gr.HbA1-7,5- therapy continues to evolve. That's 9% (N=8); 3 gr.HbA1≥ 9% (n=22). why it is reasonable the search of For the level of PA the children were alternative ways to improve the devided into groups: 1 group- PA≥ 21 compensation of diabetes mellitus of b. (n=7), 2 group-PA=18-20 b. (n=7), children, the special interest is a 3 group -PA≤ 17b. (n=22). The question about development of statistic refinement was performed optimized physical activity (PA) of by using the application Exel and this group of sick. SPSS 17.0. Purpose of the study: Explore Results: it was found that the the indicators of compensation of carbohydrate metabolism in the diabetes mellitus of sick children group is: HbA1 (9,7± 0,4)% and DG with different level of PA. (10,7± 0,5) mmol/L, that confimed Materials and methods: it is that the unsatisfactory compensation examined 37 children with diabetes of the disease of most patients. With 1 type 5-18 years old with the this the group3 with the less level of duration of disease 1-11 years. The PA the indicators of diabetes mellitus examine includes the level of is the worst: HbA1 – (11,1± 0,5)%, definition the compensation of DG (11,3± 0,7) mmol/L compared 1 carbohydrate metabolism (HbA1c group (HbA1 – (9,3± 0,5)%; DG – average daily glycemic, daily (10,4± 0,6 ) mmol/l , p,0,05. It variation of glycemia), conducting of schould be hoted, the low level of PA

22 ISIC-2016 Abstract book

significantly move abserved about p=0,47). girls (52,4% as compared with Conclusion: Children with 25,0% in boys, p=0,43), that the diabetes 1 type,the low level of PA accompanied by their more severe closely rekated with the worsening decompensation carbohydrate the compensation of carbohydrate metabolism in terms of HbA1 ((10,5± metabolism, especially in girls. 0,5)% beside (8,9± 0,7)% in boys,

Holovanova A.Yu., Pysarenko G.N. ANTISTRESS ACTION of PYRACETAMUM For the IMMOBILIZED RATS of 2- Х of MONTHLY AGE Research advisor: Kirichek L.T., professor Department of pharmacology and medical compounding, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Stress- it is a Pyracetamum on the state the specific reaction of organism, a hypothalamic-pituitary-adrenal rising up in reply to the action of system (HPAS) and to the oxidizing different unfavorable factors. equilibrium. Character of stress reaction for the Results. It is marked as a children of junior age creates pre- result of the executed research, conditions for the study offeatures that IS for experimental rats shows of action of stressprotecters in up typical metabolic violations as these terms. an increase of foods PAUL (diene The aim of work was a study conugates and malonicdialdehyde), in the experiment of antistress declines of activity of antioxidant action of Pyracetamum at the enzymes(SODAS) and immobilized stress (IS) for the rats hyperglycaemia. HPAS of rats in of 2-months age. these terms characterized by the Materials and methods. increase of gravimetric coefficient Work is executed on 18 white of thymus and amount of outbred rats of both sexes 2-months Corticosteronum in blood, that and age, Immobilization was created for intact animals differed in a high mass 90-100 fixing of rats on a back level as compared to adults, in the flow of 3 hours. Pyracetamum eosinopenia and some violation of was entered singly i.p. in a dose 20 trophism of mucous membrane of mgs/of kg 30 minutes prior to stomach. Under influence completion of design. About the Pyracetamum all metabolic indexes reaction of organism on stress and are normalized, and outside HPAS his corrections it was judged is a gravimetric coefficient of

23 ISIC-2016 Abstract book spleen. Thus there is a hypertrophy activity of goitrous gland and of, adrenal glands decline below of adrenal glands, and also norm in them ascorbic acid, less increase of level of blood sugar. expressed reduction of Application of antistress Corticosteronum in blood and preparation of Pyracetamum tendency to renewal of amount of warns development of oxidizing eosinophils. stress and, strengthening the Conclusion. Thus, IS for function of bark of adrenal young animals accompanied by gland, modulates activity of distorting the oxidizing balance, lymph- and genesis of strengthening of functional corticosteroids.

Hryhorova M.V, Sokol A.A. ADOLESCENT’S SENSORINEURAL HEARING LOSS. DRUGS USED IN TREATMENT Research Advisor: PhD, Associate Professor Ananko S.J. Department of Pharmacology and Drug Prescription Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Looking at the disease for children is characterized statistics of adolescent’s ENT by noise and congestion in the ears, diseases we marked, that there are which is accompanied by partial some cases when subjective tinnitus hearing impairment. appears. This condition is caused by The Aim: Drug-induced sensorineural hearing impairment. hearing loss therapy should be aimed We tried to find more effective to improve the state of the receptor treatments and drugs, which made structures; to normalize blood the best dynamics of disease course. circulation and lymphocirculation in Sensorineural hearing loss is a group the inner ear and the brain; to of diseases characterized by partial normalize the tissue and cellular hearing loss and broken function of metabolism of the central nervous sound reproduction due to damage system. of relevant organs: the inner ear, Results: Recently in the treatment of auditory nerve or brain center, sensorineural hearing loss medicine which is responsible for sound started to use the drug called perception. This disease is very rare "Vestibo" as it has very positive for children and it is often a impact on children’s recovery. complication of SARS or influenza. "Vestibo" is synthetic analogue of Also otitis media often leads to histamine. The main active sensorineural hearing loss. This ingredient - betahistine

24 ISIC-2016 Abstract book dihydrochloride. Betahistine affects effect. Moreover, "Vestibo" has the cochlear blood flow and central indirect effect on the arterioles and vestibular system. It possesses capillaries that are located in the strong central effect as nuclei H3- inner ear, it helps to increase the receptor antagonist of the vestibular vessel lumen, leading to an nerve, normalises neuronal improvement of the blood flow. transmission in polysynaptic Under the influence of the drug also neurons of the vestibular nuclei in seen the improvement of cerebral the brainstem level. "Vestibo" blood flow in the carotid and indirectly affects the H3-receptors, vertebrobasilar systems. After oral increases the amount of serotonin in dose betahistine is rapidly absorbed the brainstem, reduces the activity of from the gastrointestinal tract. the vestibular nuclei. It promotes the Conclusions: During the elimination of violations of the research of the drugs for treatment vestibular and cochlear system: of children’s sensorineural hearing reduces the frequency and intensity loss we can mark positive results in of dizziness, reduces noise in the the usage of "Vestibo" drug (or its ears, improves hearing in the case of analogues): children’s auditory its reduction. Drug stimulates the perception has improved and the H1-receptor, so there is no sedative noise in ears reduced greatly.

Ivanova V.S., Sokol H.N. INFLUENCE OF THE EFFECTIVENESS OF THE WORK OF PROPRIOCEPTIVE SENSORY SYSTEM ON THE FORMATION OF ADAPTATION TO THE INFORMATIVE STRESSOR Research Advisor: PhD, associate Professor of physiology Marakushin D.I. Department of physiology Kharkiv National Medical University Kharkiv, Ukraine

Introduction. The learning decisions taken by the brain and process at the Medical University increases the "price of adaptation" to during the first 3 years is associated the effects of informative stressor. with a significant amount of Objective: the purpose of the theoretical material that students study was to examine the should learn and be able to apply in relationship between proprioceptive practice. The problem arises in the perception and the process of integration of extero- and formation of adaptive reactions of interoceptive sensory system that medical students to prolonged reflects on the effectiveness of the affection of the informative stressor.

25 ISIC-2016 Abstract book

Materials and methods. In Results and discussion. In the research took part the students of initial stage of the study three groups the 2nd course of medical university, of students were formed according who signed a voluntary consent to to the level of physical training: not perform the research. Differential athletes with a low level of physical sensitivity of the proprioceptive training (Group 1)-17.4% of sensory system was investigated students; not athletes with an according to protractor`s indications average level of physical training, during the student`s playback of which do regular exercises almost specified movements in the space. regularly (Group 2)-69.3%; the third The time and precision of playback group consisted of athletes with of movements were considered. The moderate exercise schedule - 13.3% ability to adequate afferent synthesis of the students. On a scale of testing was evaluated by the sensorimotor of Spielberg-Hanina most students response SMR to the sound. The state (79.5%) with a high level of anxiety of anxiety as a psycho-physiological are determined in the group №3. property of personality was This group also showed the investigated using self-test of the maximum number of students level of personal and reactive anxiety (67.3%) with errors (11.8%) during according to the scale Spielberg- performing tasks on proprioceptive Hanina. With the help of a survey perception. Accordingly, in this each study group was divided into group mental operability and mental three subgroups according to the pace according to Kraepelin`s degree of physical training. The method showed a low percent of the calculation of Kerdo autonomic index volume of executed work and an and Hildebrant`s index was made in increased number of errors in its order to clarify the level of physical execution. Indicators SMR to the training and questions of autonomic sound were quite high. reactivity, autonomic support of Conclusion. The proprioceptive activities of the body in the dynamics sensory system of the students who of adaptation to the informative exercise their body systematically stressor. The indicators of mental and metered showed its health and mental pace were effectiveness in the process of determined by the method of forming of adaptive reactions to the Kraepelin. informative stressor.

26 ISIC-2016 Abstract book

Kalashnik E.I., Sheyan D.N., Liutenko M.A., Topchyi S.V. THE REASONS AND KINDS OF DALTONISM. CHANGES OF THE COLOUR, RECEPTORS OF THE EYE Department of Human Anatomy, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Ability to blue, pink, and also a violet shade distinguish colour and shades is of and their combinations. A the huge practical value for the combination of the red and green person. When business concerns were perceived as one colour. At certain areas of life inability to passing the Ishihara test examinees distinguish colours can become a defined the majority of the colours serious problems. From references it represented in drawings almost became known that the reason of without effort and only some images impossibility of the adequate colour have caused difficulties. In a case perception is the dysfunction of with polychromatic tables by Rabkin cones. Daltonism divides into three the results completely coincided types: abnormal dichromate, with the description have been dichromate, monochromatic, the confirmed at 14 men and 7 women perception of dichromate: with colour blindness in a green part deuteranopia, tritanopia. Daltonism of a spectrum - deuteranopia. The signs are individual in each specific blindness in the red part of a case but, nevertheless, there are spectrum, protanopia, was revealed common features. at 5 men and 2 women. At other The aim to study features of people abnormal trichromate has sight at the people suffering been revealed. daltonism, to check up and compare Conclusions. By results of accuracy of trouble-shooting tests on testing, polychromatic tables by revealing colour blindness. Rabkin have shown split-hair Material and methods. Experiment accuracy in comparison with the was spent by means of Ishihara test. Having studied polychromatic tables by Rabkin and materials on the given theme it trouble-shooting test of Ishihara. became known that number of Colour perception check was done colour-blind people among men are on volunteers aged from 20 to 45 much more than among women (8 % years, from which 24 men and 13 and 0,4 % relatively). Medicine for women were suffering hereditary daltonism treatment does not exist, daltonism. Visual acuity was 100 %. however successful results of Results. During testing, it has treatment of daltonism at monkeys been established that examinees can by means of methods of gene distinguish the next colours: dark engineering have been published in

27 ISIC-2016 Abstract book

2009. Also there are methods of people are normal and adequate correction of colour perception by people who have no other problems means of special lenses. Colour-blind with health.

Kalinichenko D. INFLUENCE OF NUTRITION AND METHOD OF THE POWER FOREIGN STUDENTS ON THE STATE OF THEIR HEALTH Research advisor - Associate Professor Digol L.G. Department of Medical Biology, Kharkiv National Medical University Ukraine, Kharkiv

Actuality. Every foreign student Results. The results showed aspiring to study abroad inevitably that the type of food the students are faces a number of problems divided to three groups: 27.5% associated with the new language, preferred to eat in the university cultural and social environment. cafe, as much in the national cuisine Factors such as isolation from the restaurants, 45% - at home. The home, poor nutrition have a average caloric intake of the students significant impact on the health of eating in the university cafe was students and, respectively, to their 1760 kcal, the students eating in the academic performance. The increase national cuisine restaurant - 3800 in students about the diet products kcal, at the home diet - 2600 kcal, of rapid preparation of food while as in mental work on average containing different flavors, jams, need to consume 2300 kcal. The dyes, modified components becomes increase in the diet of fast food foods a serious risk factor for many mentioned 50% of the students. diseases. Studying of revealing health The aim of studying is identify surveying students deterioration to the relationship between the nature 45% of students, with 67% of these of nutrition of foreign students and were gastrointestinal disease in the their state of health. 22% - metabolic disturbance Materials and methods. A (obesity), in 11% of cases - survey of 40 students from cardiovascular diseases. Turkmenistan (40%), Uzbekistan Conclusions. Results of the (37.5%), Azerbaijan (27.5%) and study indicate that foreign students Georgia (20%). The questionnaire health has a significant impact not included questions concerning the only life style associated with high type of food, caloric intake and food mental stress, but also eating habits preferences, and changes in health in a new environment too. Changes status after his arrival in Ukraine. in the nut, cooking techniques, diet

28 ISIC-2016 Abstract book require a certain period of disability of students of higher adaptation and can lead to an educational institutions. increase in chronic diseases and

Khalimov E.G., Sokol A.A. PHYSIOLOGICAL CHARACTERISTICS OF CEREBRAL CIRCULATION IN THE PRENATAL Research Advisor: PhD, Associate Professor. Vashuk N.A. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Study of the join to the cerebral part of vertebral physiological characteristics of artery. cerebral circulation in the prenatal Microcirculation of the brain is is an important subject, because for a derived from the radial vessels normal development of all organ extending from the pial arteries. systems, particularly the brain must Different brain structures have be adequate provision from the unequal capillary density, the circulatory system. location of which is depends on Results: Having analyzed further functional part of the brain literary sources, I found that blood important: in the gray matter exist vessels begin their development with more developed capillary density scattered vascular plexus formed than in white; in the cerebral cortex, between the endoderm and cerebellum and paraventricular mesoderm of the yolk sac, i.e outside hypothalamic nuclei of these vessels of the embryon body. The internal is greater than in other regions of the carotid artery (one of the main brain. The primary blood collection sources of blood supply to the brain) system of capillary head consists of a are derived from the third pair of gill primary head vein. The primary head arches (carotid arc) .In front of the vein flock dural front, middle and arc dorsal aortae form the rear capillary plexus. Due to the continuation of the internal carotid growth of the auditory capsule and artery. Each divided into anterior middle ear former course of the and posterior branches, the first primary head vein becomes branch is given to the eye, the unprofitable, and one of its areas is anterior and middle cerebral atrophy. To make the necessary arteries, and latter turn back and adjustments, above the otic capsule is formed anastomosis and

29 ISIC-2016 Abstract book secondary plexus are now flows into Conclusions: So I considered the rear plexus. All that remains of the development of the main blood the primary veins of the head can be vessels that participate in the blood called cavernous sinus. The drainage supply to the brain. It can be of the cavernous sinus is done concluded that the central nervous through the barrel middle plexus, system, particularly the brain, has a which gives rise to the upper close relationship with the sinuses, and through it goes to the circulatory system, without which formed spinal canal, giving rise to the normal developmenti is impossible. transverse sinus.

Khromey E. THE INFLUENCEOF LOW FREQUENCY LASER LIGHT ON THE SENSITIVITY OF ERYTROCYTES GLYCOCALIX Research Advisor: professor Ieshchenko V. Department of Pathological Physiology of D. Alpern Kharkiv National Medical University Kharkiv, Ukraine

Actuality: The majority of the under the source of EMR. The people of Ukraine use mobile density of the flow of radiation made network. There are messages that up 5 mWt/cm2, the exposition made electromagnetic radiation has an up 20, 40,60,80,100 min.. after the adverse effect on the human expiration of the periods of time the organism. But the mechanisms of blood was taken away to study the such activity are not fully studied. saturation ability of glycocalix before The aim: to study the change of and after the influence of laser light. the sensitivity of erythrocytes All the samples were incubated with glycocalix to the low frequency laser the dye alcian blue during 30 light (LFLL), primarily subjected to minutes, after what with the help of the influence of electromagnetic centrifugation in the supernatant radiation (EMR) which is liquid the contents of the dye were characteristically close to the determined. standards of the mobile network Results: It was determined that, GSM 900. after the influence of EMR the Materials and methods: The erythrocytes became more sensitive experiments were conducted with to laser light. the frog erythrocytes. Blood was put

30 ISIC-2016 Abstract book

Knigin M. FACTORS, WHICH INFLUENCE THE PROCESS OF SELF-EXCITATION OF THE HEART Research advisor: Vashchuk N., associate professor, PhD Department of normal human physiology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Ability of action influence electrocardiography, they potential spontaneous generation are – breathing, physical irritants, with no any external stimuli food consumption, drugs affection, (automaticity) is a characteristic of conditioned irritants and body atypical cardiomyocytes, which make position. During breathing act, up cardiac conduction system. This especially in act III, ECG peaks potential spreads over the direction and amplitude are very myocardium, causing sensitive to any axis deviations cardiomyocytes conduction. Heart is during inhalation and exhalation. devoid of extracardiac innervation, During inspiration process, R-wave but because of intracardiac nervous decreases in act I and increases in act system availability, heart sustains III, as for S-wave, it decreases in act its`s pumping function. Efferent III. During deep inhalation, T-wave fibers and atypical myocytes form decreases in act I, in act III T-wave irritant cardiac conduction system increases or becomes distorted, it for typical cardiomyocytes. becomes negative instead positive, Electrocardiography is one of cardiac or vice versa. Primary, this changes automaticity research methods. ECG are caused by heat reposition during results primary depend on inhalation and exhalation. Physical anatomical individuality of cardiac exercise always cause deep changes conduction system, on ratio of right in ECG-examination results. In and left ventricle muscle mass, on healthy person, it usually appears as heart surrounding tissues electric heartbeat rhythm acceleration. conductivity and substantially on During functional testing with nervous system reactivity of physical activity, there can be found different people – features of changes which may clearly show nervous reaction on internal or pathological changes in the heart, external impact influence factors. they are: presence of severe Results. There were 28 ECG- tachycardia, arrhythmia, atrial examinations analyzed. It was fibrillation, heart blocks et. founded, that internal and external According to this, ECG-examination organism factors may influence on allows us to determine pathology of cardiac automaticity. There are also almost all basic heart physiological a lot of physiological conditions may processes. Presence of rhythmic

31 ISIC-2016 Abstract book complexes on ECG, tells us about arrhythmia is called respiratory sinus rhythm. Speeded, comparing arrhythmia, because it arises as a with the norm, heart rate tells us result of vagal nerve tone changes about tachycardia, slowed down during breathing phases change. heart rhythm is called bradycardia. Rhythm disturbances are also Sometimes, during inhalation in express as so-called “nodal-rhythm” exhalation process, heartbeat rate appearance, in which master node may increase or decrease. This role leads to atrioventricular node.

Kolodyezna T.Yu., Dobrova V. Ye. THE ANALYSIS OF THE UKRAINIAN RECS WORK AS A PART OF THE TRIAL SUBJECT PROTECTION SYSTEM National university of Pharmacy (Department of Clinical Pharmacology and Clinical Pharmacy), Kharkiv, Ukraine [email protected]

Background. Ukraine has high The aim of this work was to potential in the field of clinical trial study approaches in RECs (CT) of new drugs holding. According organization in Ukraine and to to the regulations in CT holding the identify challenges to the effective start of any CT is impossible without functioning of the REC system in its approval by the research ethics Ukraine for increasing the trial committee (REC). RECs are the third subjects’ protection. party in the trial subjects’ protection Materials and methods. The side by side with State expert center interview of the 104 RECs was held and researchers. Our analysis of to evaluate the accordance of the literature sources showed that the RECs to the regulatory requirements. world's great attention is paid to The developed questionnaire assessing and improving the quality consisted of two parts and contained and efficiency of the RECs work. In questions about RECs’ work Ukraine there are about 500 local organizing, membership and research ethics committees (RECs) members’ educational training. The that perform the review of different analysis of the obtained results was health research projects including made with the help of generalization, clinical trials of drugs and medical modeling and content analysis devices. As for today their work isn’t methods. studied enough. This could hinder The results. The analysis of the effective protection of human the obtained results showed that subjects. most of the RECs (60.9%) are functioning 6 – 10 years. At 26% of

32 ISIC-2016 Abstract book

RECs the head and at 78.3% - international regulations for CT. members of RECs were assigned by 17.4% of RECs don’t use their policy the healthcare institutions in work what contradicts with the administration where the RECs are regulatory requirements and could functioning. The head appointment lead to decreasing of the trial by the healthcare institutions subjects’ protection. administration contradicts with the 26.1% of RECs have conflict of national regulations. Also this could interest with the researchers and be the reason for possible conflict of 60.9% - don’t have any. But our interests during ethical review of the research showed that they could CT since on this fact shows the have latent conflict of interest. dependence of the RECs from the Conclusions. Our study healthcare institutions showed the need of farther research administrations. on RECs’ work, elimination of conflict 100% of RECs use national of interest and development of tools regulations in their work; 95.7% use to assess the quality and GCP, 65.2% - declaration of Helsinki, effectiveness of the RECs work to other documents are little known increase the trial subjects’ and used in work. This shows not protection. enough awareness of RECs in

Kolotilov A., Likha V., Kovaliov M. THE INVESTIGATION OF THE MENTAL EFFICIENCY IN THE DYNAMICS OF THE EDUCATIONAL MOTIVATION DEVELOPMENT IN STUDENTS WITH THE INDIVIDUAL CHARACTERISTICS OF THE INNER TIME FLOW RATE Research advisor – PhD., Assoc. Marakushin D. Department of Physiology, Kharkiv National Medical University, Ukraine, Kharkiv

Actuality. Nowadays, the nerves system and the problem of the increasing number of psychophysiological perception of people, who feel informational the time. overstrain, is topic. It is more actual The aim of the research was to for students. The mental efficiency of study correlations of the individual person is determined by many flow of the inner man time, the factors, the main of them are the mental efficiency and the dynamics level and the condition of the health, of the educational motivation the dynamics of the educational development in adaptation motivation development, the conditions to the informational individually – typological features of stress.

33 ISIC-2016 Abstract book

Materials and methods. The the most exsperssed emotional resource was conducted on 46 reaction to fails and the approach to medical students, agreed to take part the tests as a competition for the in the experiment. To determine the best result. In the dynamics of the flow rate of the internal time educational motivation development measured the length of the extremly changed – from the highest individual minute and evaluated the interest to the complete apathy. The accuracy of measuring a set time mental efficiency of students with interval. The mental efficiency was decelerated flow rate of the internal evaluated by Kraepelin's test. The time (22 % of the testees) was the changes of the motivation to the lowest (they solved only 42,3% ), but cognitive activity was studied by the the number of mistakes was in 2,5 repertory grid technique of J. Kelly. times lower than students from the Results. Students have been first group. The dynamics of the divided on 3 groups according to the educational motivation rose slowly. main types of individual internal The amount of the ”balanced” passage of time: accelerated, students performed work (63,9%) decelerated and "balanced" (the flow was 78,5% with the lowest number rate of the internal time was the of mistakes (3,4%), which same with the flow rate of the corresponded the highest efficiency. physical time, the error does not The dynamics of educational exceed 5 seconds). Students with motivation characterized ensure accelerated flow rate of the internal sustainable growth. time (13,9% testees) have showed Conclusions. Internal time the highest level of the mental flow rate fairly reflects qualitative efficiency productivity – 89, 9% of and quantitative indicators of the the right answers, in the same time mental efficiency and explains the they have showed the hight number personality of the educational of the mistakes – 19, 7%. In this motivation development. group student have demonstrated

34 ISIC-2016 Abstract book

Korsunov K.V MONOAMINE CONTENTS IN CEREBELLUM OF BRAIN IN SUBMISSIVE AND DOMINANT RATS Research Advisor: PhD, Associate Professor Popova L.D Department of Biochemistry Kharkiv National Medical University Kharkiv, Ukraine Actuality. Neurophysiological Aim. The aim of the and biochemical studies of investigation was to study the neurotransmitter status, providing contents of serotonin, the aggressive and depressive states norepinephrine and dopamine in formation, mainly focused on cerebellum of submissive and structures of emotiogenic limbic- dominant rats. neocortical systems of brain. At the Materials and methods. Work same time, the role of cerebellum in was carried out on 24 male rats of these processes has not been the young reproductive period. studied, although cerebellum, which Distribution of animals into groups is an important structure of with alternative types of behavior locomotor function regulation, was made using a model of obviously is involved to the emotional stress “Sensory contact” realization of aggressive behavior. with some modifications. According Furthermore, in recent years the to the results of testing, the animals articles, according to which the were divided into 3 groups: cerebellum is involved in regulation dominant, balanced and submissive. of higher cognitive and emotional Contents of dopamine, functions, were published. Two norepinephrine and serotonin in forms of aggression in men are cerebellum were determined by known to be described: impulsive fluorometric micromethod. and controlled (in animals - Results. According to the spontaneous and adaptive, results, submissive and dominant respectively). Impulsive aggression rats differ in content of all studied is observed in patient with parameters in the cerebellum. In depression. Submissive rats can dominant rats the serotonin and serve as experimental model of dopamine contents were higher, and depression. Dominant rats the content of norepinephrine was demonstrate adaptive aggression. lower compared to submissive Monoaminergic brain systems have a animals. Rats with a dominant type great influence on the emotions and of behavior didn't differ from behavior in humans and animals and balanced animals on the content of are involved in development of dopamine and serotonin, but the depression and aggression. noradrenaline level in the

35 ISIC-2016 Abstract book cerebellum of these animals was the cerebellum with the cerebral reduced. Serotonin and dopamine cortex and limbic system structures levels were significantly lower in and the same direction of biogenic cerebellum of submissive rats amine content changes in compared with balanced animals. cerebellum, frontal cortex and These results are consistent with hippocampus, it can be assumed that previous data on the content of the cerebellum is involved in the biogenic amines in the hippocampus formation of dominant/submissive and frontal cortex. behaviors, in the development of Conclusions. Taking into aggressive and depressive states. account the neural connections of

Kuznetsova D. RECENT DATA ABOUT MOLECULAR UNDERPINNINGS OF METABOLIC SYNDROME PATHOGENESIS Research Advisor: Professor Leshchenko V. Department of Pathological Physiology named by D. Alpern Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Metabolic syndrome different factors NF-kB is been includes diabetes, obesity, arterial transporting from cytoplasm to hypertension, ischemic heart disease. nuclear and activates a big amount of This syndrome got a title ”deadly genes. NF-kB is one of the key quartet”. molecules detecting Pathogenesis of metabolic syndrome proinflammatory reactions in cells is very complicated. It is studied and stimulates synthesis of the TNF- intensively. α, IL-1, IL-6, which cause insulin Materials and methods: resistance. Most lipids, including Nowadays a great attention is payed nonesterified fatty acids, can activate to the part of insulin resistance as a NF-kB. Lipotoxicity declares itself as link of parts of metabolic syndrome. ”adiposopathy”. Adipocytes and Hyperglycemia is developing without macrophages, infiltrating adipose insulin and it stimulates secretion of tissue, secretes mediators of insulin, so increasing of insulin level inflammation, which, in addition, in plasma can cause heavy insulin aggravate atherogenesis. glycemia redoubles ability of Results: So, insulin resistance, angiotensin II to activate a nuclear arterial hypertension, dyslipidemia, factor kB (NF-kB) in smooth muscles cardiovascular diseases can be cells of vessels. Under influence of considered as manifestations of

36 ISIC-2016 Abstract book pathological process, central NF-kB. molecule of which is the activated

Markiv A.I. FEATURES OF THE CARDIOMETABOLIC DISORDERS AND STRUCTURAL- FUNCTIONAL STATE OF MYOCARDIUM IN PATIENTS WITH HYPERTONIC DISEASE AND DIABETES MELLITUS Research advisor: Bobronnikova L.R., professor Department of Clinical Pharmacology, Kharkiv National Medical Iniversity, Kharkiv , Ukraine

Actuality. Еssential (BMI), the patients were divided into hypertension (EH) and diabetes type groups: group I (n = 43) BMI 2 (DM-2) are the two of the most averaged 32,07±3,12kg / m²; group developed diseases in the world. II (n = 42) - 25,07±4,22kg / m². The Comorbidity of EH and DM- 2m may average blood pressure in patients of cause the early development of both groups was: SBP 160,50 ± 2,14 damages of target organs and and DBP 97,40 ± 1,91 mm hg. We subsequent cardiovascular evaluate the performance of catastrophes. The EH and DM-2 transthoracic echocardiography share many common pathogenic parameters and daily monitoring mechanisms that influence on the ofBP (DMBP). development of comorbidity. The results of the research. The aim of the research. To In the I group the content of total make an analytic review of literature cholesterol (TC) was on average 23% about features of metabolic higher in comparison with the disorders in patients with essential indexes of group II (p <0.01), hypertension and impaired body concentration of LDL cholesterol weight, identify the relationship increased by 30% (p <0.01) with a between structural and functional decrease in cholesterol levels HDL by parameters of the left ventricle (LV) 29% (p<0.01). The degree of and the daily profile of arterial reduction of nocturnal SBP was pressure (BP) in patients with EH in associated with BMI (r = 0,52; p combination with DM-2. <0.05). Materials and methods of The content of C-reactive research. 85 patients (47 men and protein (CRP) of blood serum in 38 women) with EH 2 stage and 2 patients in group I was 49% higher degree. The average age of the in comparison with indicators of patients was 56,8 ± 4,6 years. group II (p <0,01) and correlated Depending on the body mass index with SBP (r = 0,37; p <0,01), content

37 ISIC-2016 Abstract book of LDL cholesterol (r = 0,42; p early diastolic wave motion of the <0,001) and VLDL (r = 0,39; p mitral valve (r = -0.51; p <0.05). <0,001). In patients from the group I Сonclusion. The state of GB was found a significant increase in and diabetes type 2 in people with left ventricular posterior wall abdominal obesity appears much thickness (TZSLZH) by 17% (p more expressed changes in systemic <0.05) and the size of the left atrium metabolic changes and progression (LA) by 20% (p <0.05). In Group 2 of atherogenesis. It was found the patients revealed a direct correlation increase of blood pressure variability between blood pressure variability with a predominance of concentric and TZSLZH (r = 0.67; p <0.05) and LV hypertrophy (68% of patients) an inverse correlation between with the formation of diastolic average daily variability of blood dysfunction. pressure and the maximum rate of

Martynenko A.A., Zelenskaya A.N. PSYCHO-PHYSIOLOGICAL FACTORS OF ADAPTATION IN MEDICAL STUDENTS TO PROLONGED ACTION OF INFORMATIONAL STRESS Research Advisor: Assistant of Professor Marakushin D.I. Department of Normal physiology Kharkiv National Medical University Kharkiv, Ukraine

Introduction. According to the Objective: the purpose of the WHO in 2001 a fundamental rule of study was to find the ways to ability to live in happy healthy improve the efficiency of the mental human body is "ability to adapt to works in medical students with ever-changing conditions of the condition of preservation the healthy external and internal environment". functioning of the body. In modern conditions of scientific Materials and methods. The and technological progress a person study involved students of the 2nd must conscious and motivated to course medical university, who take responsibility for their own signed a voluntary consent to health. This is especially true of perform the research. Indicators of people whose professional activity is mental health and mental pace associated with the dominance of determined by the method of E. mental work on the background of Kraepelin. The ability to adequately long-term exposure information afferent synthesis was evaluated by stressor. the sensorimotor reaction (SMR) on the sound. Psychophysiological

38 ISIC-2016 Abstract book condition of the person evaluated on Accordingly, in each group was a scale Spielberg-Hanina. Eysenck carried out tests of mental test for IQ level were performed in operability and installation work on conditions of emotional well-being, the sound at the beginning of to the maximum level of error from research and in the dynamics of the emotional stressor. Efficiency of training during the school year the general adaptive reaction, before the exams. At the end of each vegetative reactivity and vegetative semester determined the level of support of the organism were anxiety. During the semester carried out by calculating the pedagogical observation conducted vegetation index of Kerdo and the degree of systematization the Hildebrant index. Deviation these accumulation of knowledge by indexes from standard values students and their efficiency of indicates the degree of misalignment assimilation, as well as psychological of the vegetative regulation of and pedagogical correction of visceral systems in the process of training mental operability. adaptation to the informational Conclusion. Students who stressor. regularly maintained their Results and discussion. In the professional knowledge at a level initial research stage a group of sufficient to perform the program students in the amount of 35 people tasks of training, have shown with an average IQ level has been efficiency of mental work and formed. On a scale SpielbergHanina reducing mental stress. For testing, study group was distributed maximum number of students of this as follows: 18.9% were students group (84.7%) general adaptation withhigh levels of anxiety (Group 1); reaction of the body to the action 60.7% showed an average level of duration of the information stressor anxiety (Group 2); 20.4% of students defined as adaptive response with low levels of anxiety (Group 3). training.

Maslova J. FEATURES OF THE ACCOMMODATIVE-CONVERGENCE SYSTEM OF TEENAGERS Research advisor: Maslova N., Candidate Medical of Sciences Department of Physiology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Conservation of formation of visual system taking visual function of teenagers and into consideration physiological creating essential conditions of features of an organism.

39 ISIC-2016 Abstract book

Aim. Necessity of studying age pronounced in the group of females. features of the accommodative- This process testifies about convergence system of teenagers to worsening of the functional reveal the basis laws of adaptation to capabilities of the visual system, visual load. especially among females. It is Matherials and methods. The generally accepted that the near point of convergence is a completion of the formation of the complex characteristic of the visual system occurs in 15-16 years. accommodative-convergence system However, according to the survey, and is defined as the minimum the processes of changing of distance from eyes. The least functional parameters are not distance of distinct vision (LDDV) is finished. In any functional system defined monoculary (excluding after its "gestation" should be a accommodative convergence, i.e. the period of a stable functioning. In the strengthening of the accommodation visual system, this interval should at the convergence). Investigation of include the period between 15 - 16 the least distance of distinct vision years and up to 30 - 40 years old. (LDDV) and the near point of Based on these results, we can say convergence was conducted on 48 that the formation of the visual students of 2nd year at the age of 19 system gradually goes to its - 20 years. Of them 21 persons are functional worsening without males and 27 persons are females. stabilization phase. Results. Mean value of the Conclusions. It turns out that LDDV of males in 19 years is 8.1 cm any other functional system of the (ОD), 7.4 сm (ОS), in 20 years is 8.5 body, which is subjected to load at cm (ОD), 7.6 сm (ОS); the NPC in 19 full capacity, trains and improves its years is 5.9 сm, in 20 years is 6.8 cm. function, i.e. through stress produces Mean value of the LDDV of females in structural trace of adaptation. When 19 years is 7.4 cm (ОD), 7.1 сm (ОS), the visual system is subjected to load in 20 years is 8.7 cm (ОD), 8.0 сm at full capacity, training of system (ОS); the NPC in 19 is 5.3 сm, in 20 and improvement of its functions years is 7.9 cm. From these facts we does not occur, in contrast the see that the convergence leads to worsening of its capabilities and increased accommodation reducing of reserves, up to approximately on 1.5 D. The position development of spasm of of the NPC is removed from the eye accommodation and myopia occurs. with age, and this is more

40 ISIC-2016 Abstract book

Matsak Denis ANATOMY OF POLYCISTIC KIDNEYS Research advisor: C.med.science Ghranyna Elena Department of Human Anatomy Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Kidneys are the one characterized by erythrocyturia, of the most important organs of the arterial hypertension (BP > 140/90 urinary tract. A kidney is a mm Hg), renal pain especially at parenchymatous organ which basic early stages. Pain syndrome is function is to remove excess of water stipulated by cystic pressure on from blood, electrolytes, and waste adjacent structures , cystic products of metabolism. There are hemorrhage, cyst rupture. With the many kidney pathologies which lead help of the ultrasound investigation to dysfunctions of these organs. One it was determined that average size of them is polycystic kidney disease. of a healthy kidney is: length – 11,23 Polycystic kidney disease is a cystic cm, width – 5,52 cm, thickness – 4,23 degeneration of a kidney cm, the parenchyma thickness – 1,69. parenchyma. Cysts form as a result of Kidney increase is typical for the increased proliferation and polycystic kidney disease. The tubule epithelium differentiation of following results were made after 30 nephron. As a result instead of patients aging from 30 to 60 years regular there form bubbles filled old with polycystic kidney disease with primary urine – cysts which had been examined with the lead to the considerable increase of a ultrasound: right kidney in average – kidney in size. Polycystic kidney length – 15-20,6 cm, width – 8,12 – disease can be two types: acquired 10,7 cm, parenchyma thickness – 1- polycystic kidney disease which 1,2 cm, kidney thickness – 7-8,26 cm. occurs as a result of a long-term Cysts are revealed at polycystic nephratonia and autosomal kidney disease. The size of cysts in dominant polycystic kidney disease, average are: 1-5,16 cm. more rarely autosomal recessive Conclusions: Polycystic polycystic kidney disease which is a kidney disease has following congenital pathology. This pathology characteristics- kidney increase in manifests clinically in children very both length and width due to the cyst rarely. As a rule disease growth, thinning of a kidney manifestation is registered in people parenchyma. As a rule above- elder than 30 years old but with age described structural changes lead to the incident frequency increases. the development of nephratonia. Due Polycystic clinical pattern is to this disease hemodialysis or

41 ISIC-2016 Abstract book peritoneal dialysis must be pathology. prescribed to patients with this

Dr. Alexander Mokanyuk, Dr. Mahammad Novrusov, Dr. Lesia Yekenina COMPUTER PROGRAM MATHCAD AS AN OBJECTIVE WAY TO DETERMINECOLOR (FOR THE FORENSIC MEDICAL PRACTICE) Vinnitsa National Medical Memorial University named by M.I Pirogov (Department of Pathological Anatomy, Forensic Science and Law) Vinnitsa. Ukraine

Relevance: determining the separately, white and orange colors color of damage is subjective, which of the line, according to which the can lead to errors in the results. That application is calibrated. Regardless is why this process requires of the source format of the file the objectification and standardization image in MathCAD is a matrix, color that can be achieved using computer values of which spreads from 0 technologies. (black) to 255 (white). Each element Objective: To determine the of the matrix is 1 pixel of the image. possibility of using MathCAD The program has three matrixes of program for digital image processing colors: red, green, blue (system and objective definition of the color. RGB). The combination of these Materials and Methods: three colors is able to reproduce any photos of damaged skin were made color. Each pixel on the reference by NikonAF-SNikkor 18-15 mm image was calibrated according to camera, using shadowless lighting the standard color (orange) with the Xenon lamp, from a distance of 40 balance of white and was compared cm, perpendicular to the skin with RGB colors. After that the surface. The color and size of lesions corresponding numerical value that were determined according to the corresponds to a color line was scale model of color metric scale. attached to each pixel. These data is Photos of the injuries were recorded in Microsoft Excel processed in the graphic editor spreadsheet and were used for Photoshop. From each image in a objective determination of the color graphics editor 4 images were cut: of damage. the actual damage, clear skin, one of Conclusions: The use of a the colors of the line and white. computer program MathCAD for Result: for the processing in processing digital images provides MathCAD program we took four the objective determination of the images: the actual damage, clear color of injury for purposes of skin, which were processed forensic practice.

42 ISIC-2016 Abstract book

Moskalenko V., Sirenko V. MAGNESIUM LEVEL IN PANCREAS OF RATS AND THEIR OFFSPRINGS IN LESS NUTRIENTS DIET CONDITION. Research advisor Kovaltsova Maria, PhD Department of Pathophysiology Kharkiv National Medical University, Kharkiv, Ukraine The relevance. Magnesium Offspring's from the first group of disbalance is an actual medical rats has the same pancreas problem, that appears in a dysfunctions as their mothers do hypocaloric nutrition, and can cause (except for 100% ductual pancreas exocrine and endocrine pancreas fibrosis and lack of lipomatosis). pathologies. Further pancreas dysfunction The aim of the study Is a reduces, specifically inflammational research of rats’ pancreas infiltration disappears (after 1 morphofunctional state and month) and the frequency of 2- ascertainment magnesium level after month rats’ sclerosis appearance a disbalanced diet. goes down. After 2 months The materials and methods. lipomatosis (in 50% of cases) and Pancreas morphofunctional state is ductus dysfunction (in 100% cases) researched on pregnant rats while is found. This leads to pancreas they were on hypocaloric diet (1 functional condition violation. group) and their 1-2 month Biochemical research results show descendants. Also pancreas that 100% of rats that belongs to the morphofunctional state of species on first group have undervalued balanced nutrition is ascertained (2 magnesium level relative to second group). Pancreas magnesium activity group’s same index and it is 91,2%±3 is researched by (р1<0,01). Offspring from the first spectrophotometrical method. group have the same pancreas The results. The research dysfunctions as their mothers do: results shows that 100% of rats in 100% of 1-month rats this result is the first group has morphofunctional 86%±1 (p<0,001), 100% of 2-month changes in pancreas: parenchymal species this result is 71%±1,4 (p < atrophy and stromal hypertrophy, 0,001) of a control group’s result. inflammational infiltration (40%), The conclusion. Thus, rats on acinar area and pancreatic islets hypocalorical nutrition and their decrease and endocrinocytes descendants have magnesium number in a part of pancreatic islets disbalance in front of decrease. No signs of haemocapillars morphofunctional changes of or ductus malfunctions are found. pancreas and pancreocytes.

43 ISIC-2016 Abstract book

Mukherjee Pratibha INTERRELATION BETWEEN DOPAMINE CONTENTS IN CEREBELLUM AND EMOTIOGENIC LIMBICOCORTICAL SYSTEM REGIONS IN RATS WITH DIFFERENT BEHAVIOR TYPES Research advisor: Popova L., MD, Doctor of Medical Sciences Professor Department of Biochemistry Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Dopaminergic was determined by fluorometric projections to limbic & cortical micromethod. Statistical analysis of structures regulate cognitive and the results was carried out by emotional functions. Limbic methods of nonparametric statistics projections influence cerebellum, & using the package “Statistica 6.0”. cerebellar activity modulates Results. The significant dopamine release in medial decrease of dopamine was found in prefrontal cortex. Cerebellum role in all investigated structures in aggressive and submissive state submissive males compared with development was not studied. both balanced and dominant rats. Aim. Taking into account that The difference in dopamine content frontal cortex and hippocampus are between dominant and balanced involved in control of anxiety and animals was observed only in frontal aggressive behaviour, the aim of the cortex. Dopaminergic system forms investigation is to study the hedonistic behavior components. interrelation between dopamine Dopamine plays the key role in contents in cerebellum and frontal behavioral disinhibition and cortex and hippocampus in male rats anxiolysis. The decrease of dopamine with alternative behavior types. content in frontal cortex and Matherials and methods. hippocampus in submissive males Work was carried out on 24 male promotes the formation of rats of the young reproductive submissive behavior. The analysis of period. Distribution of the animals correlations between the content of into groups with alternative types of dopamine in cerebellum and behavior was made using a model of structures of emotiogenic neocortical emotional stress “Sensory contact” system revealed the existence of with some modifications. According close positive correlation between to the results of testing, animals the content of dopamine in were divided into 3 groups: cerebellum and frontal cortex dominant, balanced and submissive. (submissive: + 0.881, P<0.05; Content of dopamine in frontal dominant: + 0.779, P<0.05), in cortex, hippocampus and cerebellum cerebellum and hippocampus

44 ISIC-2016 Abstract book

(submissive: + 0.887, P<0.05; formation of submissive behavior in dominant: + 0.683, P<0.05) both in submissive males by reducing the dominant and submissive males. mediation of positive emotional This tight positive correlation may reactions. The existence of close be explained by receiving excitatory positive correlation between input and sending reciprocal dopamine contents in cerebellum projections to the medial prefrontal and structures of emotiogenic cortex by dopaminergic neurons in limbicocortical system is a evidence the ventral tegmental area, and by that cerebellum is involved in the modulatory effects of cerebellum on formation of dominant/submissive dopamine release in medial behaviors. Dopaminergic system is prefrontal cortex. one of the mediatory systems of this Conclusions. The decrease of involving realization dopamine content promotes the

Nabok T.A., Zelenska A.N. ON THE QUESTION OF THE EFFECTIVENESS OF PSYCHOPHYSIOLOGICAL METHODS OF DIAGNOSTICS OF EDUCATIONAL MOTIVATION OF MEDICAL STUDENTS Research Advisor: PhD, Associate Professor Marakushin D.I. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. The content and the test and really reflect his attitude structure of human motivation is a to reality. significant indicator of the state of Materials and methods. The health and level of adaptation. In study was conducted on medical terms of psychophysiology, learning students of the 2nd course, who gave motivation is the basic social needs free and informed consent to of man. Study the content and participate in the experiment. On the structure of cognitive motivation of basis of information retrieval have medical students is an actual been selected: the traditional problem of psychophysiological. psychodiagnostic methods Aim: The aim of our study was (questionnaires and projective); to find motivation diagnostic technique of repertory grids of J. techniques of cognitive activity, Kelly (adapted for the study of which would have a reliable degree individual changes in teaching and of protection from the insincerity of learning motivation of students) and psychosemantic method of color

45 ISIC-2016 Abstract book metaphors in modifications of I.L. high demands on the level of Solomin. The method of color education and intellectual metaphors was adapted by I.L development of the respondents. He Solomin for the quantitative also proved to be quite energy measurement, quality assessment intensive to conduct a study. The and comparative analysis of the technique of color metaphors of I.L. content and structure of a wide Solomin reliably meets the task of range of motives in people of our research. Interpretation of the different social groups. results it has identified the relevant Results and discussion. As a advantages over other diagnostic result of these motivation methods methods of motivation of cognitive of diagnosis was obtained by the activity of students. Unlike ability to analyze the motivational traditional methods of psychological variety of students in terms of the tests focused on the identification of relation with the needs of the the content and structure of hierarchical model of A. Maslow. The conscious and unconscious, as well use of traditional questionnaires and as equipment repertory grids of J. projective psychodiagnostic methods Kelly , but requires much less time for the analysis of motivational and it has a power consumtion of choice did not allow a sufficient research. degree of accuracy to identify the Conclusion. So, the technique content and the structure of of color metaphors of I.L. Solomin is motivation. Studying the dynamics of the most effective method for teaching and learning motivation diagnosing educational motivation, using a technique of repertory grids as it allows adequate for a short time of J. Kelly showed the effectiveness of to evaluate the structure of the the method in the individual cognitive motivation of medical psychophysiological research. students. However, the method makes quite

46 ISIC-2016 Abstract book

Nazarov Dmytro Ihorovich ADVANCES OF NANOPARTICLE-BASED TARGETED DRUG DELIVERY FOR CANCER TREATMENT Research advisor: Onashko Yuliya Nikolaevna, Assistant Department of Pharmacology and Drug Prescription Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Cancer is still the 15-30nm). This is different from number second cause leading to what occurs in inflamed regions or death. The reasons of these situation even in those regions where tumors are side-effects of treatment by are located, in which endothelial chemo- and radiotherapy, which cells are less packed among increases mortality and restricts the themselves than in healthy regions, opportunity of further therapy. For which result in an accumulation of example, a widely used anticancer nanoparticles in the tumor tissue drug, doxorubicin, can cause heart near blood vessel. This vectorization failure or dilated cardiomyopathy strategy is known as enhanced because of nonspecifically permeability and retention effect absorption of it by non-targeted (EPR). tissues. That is why targeted drug A number of pre-clinical tests delivery systems for cancer and epidemiologic studies can be treatment are so actual nowadays. found, which show great potential of Object. The goal of this new medications for cancer. These research is to show a great potential drugs contain macromolecules of new medications either synthetic peptides, proteins, plasmids, RNA- and from natural-source compounds DNA hybrid aptamer. Liposomes against cancer. were the first nanocarriers approved Methods and Materials. by regulatory agencies for carrier Studying, analyze and generalization several chemotherapeutic agents. of data of National Centre of The first formulation of liposomes to Biotechnology Information. be approved in the market was the Results. The use of colloidal Doxil in 1955 for treatment of Kaposi nanoparticle systems is the way, sarcoma associated with AIDS. From which may develop therapeutic those time numerous tests were effect of chemical agents and reduce made in this field. For example, since its side effects. Because these drugs May 2009 90 patients with breast are encapsulated within cancer have been treated by nanoparticles of 50-800nm, they are Polymeric micelle containing not possible to cross the vessel wall paclitaxel in South Korea. In the USA of healthy regions of the organism 72 patients with liver cancer have (the space between these cells is only been treated by Lipid nanoparticles

47 ISIC-2016 Abstract book containing siRNA since December have specific combinations of 2014. Moreover, in 2002 block nanocarriers and target molecules - copolymer vaccine containing similar to the strategies of peptides helped to treat 48 patients chemotherapy combination that can with melanoma in the US. be personalized to improve Conclusion. Numerous treatment against cancer - that will technologies are engaged in the contribute to improve therapeutic development of nanocarrier. results and reduce costs. " Oncologists in the near future should

Onikova A., Otchik A. EXPERIMENTAL STUDY OF COPPER ION ROLE IN MECHANISMS OF NEPHROPATHY Research Advisor: PhD, Associate Professor Gorbach T. Department of Biochemistry Kharkiv National Medical University Kharkiv, Ukraine Actuality. Despite the scheme received distilled water. numerous studies that have found a After 1 month animals were taken role in lipid metabolism in the out of the experiment. The kidneys development and progression of were isolated, washed of blood, certain types of kidney disease, the prepared 10% homogenates in impact of environmental factors on 0,25M Tris-HCl buffer, pH 7.4. Using lipids of cellular membranes of the differential centrifugation kidneys not known until now. membranes of subcellular fractions The aim of our investigation were distinguished..Renal cell was to study the features of lipid membrane lipids extracted by Bligh serum and membrane subcellular and Dyer and fractionated by thin fractions of kidney cells, layer chromatography on plates inflammatory interleukins in blood Silufol. serum of rats with experimental Results. In experimental nephropathy. nephropathy, a decrease in the Material and methods. membranes of all factions (except Experiments conducted on 30 rats - the plasma membrane) cholesterol males 2 months of age. The animals and increase of phospholipid daily for 1 month intragastric content. Thus, in terms of (through a tube) once injected 1 ml nephropathy induced by of an aqueous solution of CuCl2 hyperelementosis of copper the ratio concentration of 1.35 mg / dm3. The of cholesterol / phospholipids in control group of animals of the same intracellular membrane structures is

48 ISIC-2016 Abstract book reduced, and the plasma membranes cell, resulting to be violations of its - increases. The features ratio of functioning. cholesterol/ phospholipids indicate a Conclusion: various disorders change in the structure and of lipid metabolism, induсed by properties of membranes, which are hypermicroelementosis of copper, expressed in different directions play an important role in the change their rigidity and mechanisms of nephropathy microviscosity even within a single development.

Pavlichuk E. A., Panich R. V., Karnaukh E. V. HOW BRANDS OF DRUGS DEFEND THEIR PRODUCTS AGAINST OF FALSIFICATION? Research advisor: Karnaukh E. V., PhD, Candidate Medical of Sciences Department of Pharmacology and medical Prescription Kharkiv National Medical University, Kharkiv, Ukraine Actuality. The number of counterfeits. For 72% high price counterfeit drugs is growing rapidly guarantee quality of adrug, while every year. Therefore, manufacturers 92% are looking for an alternative to are looking for ways to protect their expensive drug (knowing that the product from possible fraud. analog may be fake). All the basic Nootropic drugs whose popularity is information about the drug and how growing rapidly among young it is protected from tampering, the people, are no exception. majority of respondents receives Aim. To explore how from the Internet. The drugs in manufacturers are protected from network marketing buys just 10%, counterfeiting, and can buyers to 14% buy drugs with discount. identify counterfeit medication. Relative to glycine and nootropil, Matherials and methods. We manufacturers protect them as developed questionnaires, with the follows. On the packages indicate the help of these questionnaires we number of patents, and in the interviewed 50 respondents aged 18 instructions indicate the regimen to 25 years. The forms included 12 drug. questions. Conclusions. We can conclude Results. 40% of respondents that modern society knows about the are taking nootropics, mainly threat of fakes, and many buyers of Nootropil, Glycine. 100% of drugs one way or another are faced respondents are aware of the threat with counterfeit drugs. However, of fakes, but only 30% know how to there is a tendency of having very distinguish a fake. 54% of low skills to identify the fake drug. respondents encountered We also found mistrust of

49 ISIC-2016 Abstract book respondents to doctors and confidence in the Internet. pharmacists, and a high degree of

Poliakova Veronika Viacheslavovna, Kravchenko Maksim Iurevich THE INFLUENCE OF ELECTROMAGNETIC RADIATION ON THE LEVEL OF RATS STEROID HORMONES Research advisor: Denisenko Svetlana Andreevna, Candidate of Biological Sciences Department of Biochemistry Kharkiv national medical university, Kharkiv, Ukraine

Introduction. The low- conditions to the chamber, but were intensity electromagnetic radiation not exposed to radiation. Posterity of (EMR) is one of the factors of the the main and control groups was environment, that has an adverse derived from the experiment at the impact on the human body, primarily age of three months. For biochemical on neuroendocrinal system. At the study blood serum was taken, after same time it is known that the fetal that concentration of corticosterone, organism is extremely sensitive to estradiol and testosterone was changes in the maternal endocrine determined by immune-enzyme state and to the changes in the method. environment. Results. The influence of the Aim. The wide use of low-intensity electromagnetic electromagnetic radiators stipulates radiation on female rats during of a impossibility of exception of actions pregnancy is reflected on the level of of the EMR during pregnancy. In this posterity’s corticosterone. The connection there is a necessity of females of the main group have the studying of the impact of the low- concentration 862,0 nmol/l, control intensity EMR of cantimetric range group has 658,9 nmol/l. The males of (1-10 cm) on the pregnant individual the main group have the and on the endocrine state of a fetus. concentration 1522,5 nmol/l, control Materials and methods. The group has 617,9 nmol/l. In this way experiment was conducted on Wistar significantly the level of rats. Animals were divided into two corticosterone is elevated in males. groups. The first group of animals The examination of sex hormones was exposed to low-intensity EMR of level in blood serum of experimental centimetric range for 4 hours every animals is detected the reduction of day during the entire period of estradiol level in males (control – pregnancy. The second group 1,19 nmol/l, experiment – 0,21 (control) were placed under similar nmol/l) and females (control – 1,89

50 ISIC-2016 Abstract book nmol/l, experiment –1,51 nmol/l). Conclusions. The level of testosterone is lowered 1. Animals that prenatally in females (control –1,89 nmol/l, have suffered the impact of experiment – 0,98 nmol/l), in males electromagnetic radiation have the is increased (control – 5,47 nmol/l, increased level of corticosterone, experiment – 6,32 nmol/l), Such especially in males. deviations of sex hormones 2. These features may concentration are insignificant and indicate the activation of the stress- characterize the distribution under organized structures affecting reaction rates of population’s function systems hypophysis-adrenal endocrine state. glands, hypophysis-gonads.

Polikov G., Karnaukh E. INNOVATIVE BIO-TECHNOLOGICAL DEVELOPMENTS OF UKRAINIAN SCIENTISTS IN THE AREA OF PROBIOTICS Department of Pharmacology and Prescription writing Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Malnutritional diet, comprised of live bacteria, obtained the use of antibiotics, stresses – all is through the means of genetic detrimental to our health. Nowadays, engineering by a group of Ukrainian therapeutic and prophylactic use of scientists on the basis of the strain probiotics is common in the world. Bifidobacterium subtilis. Probiotics – are medicinal Bifidobacterium subtilis are preparations based on widespread in nature and, in food representatives of normal human (bread and milk), water, air. It intestinal microflora. inhibits the growth of pathogenic Aim. To analyze the feasibility and conditionally pathogenic flora, and benefits of the use of modern creates favorable conditions for the recombinant probiotic Subalin for normalization of the qualitative and pharmacological treatment of quantitative composition of intestinal dysbiosis. intestinal microflora (bifidobacteria, Matherials and methods. lactobacilli, escherichia coli). Current literature concerning the Bifidobacterium subtilis exists in the analysis of the data representing an spore state, so it allows you to use innovative generation of probiotics V the drug in conjunction with Subalin obtained via genetical antibacterial drugs. Resistant to engineering by Ukrainian scientists. aggressive gastrointestinal tract. It Results. The recombinant promotes the development of alpha probiotic generation V - Subalin, is interferon - antiviral and

51 ISIC-2016 Abstract book immunomodulatory effects. Subalin meningoencephalitis, intestinal helps normalize microflora, prevents dysbiosis. and cures dysbiosis in patients Conclusions. Subalin – is the receiving antibacterial agents, medication without reduces the level of endogenous counterparts,which is composed of intoxication, improves the body's Bifidobacterium subtilis, and has resistance to viral infections. Shows been in coexistence with a man for polytropic therapeutic effects millions of years. 2. Polytropic (immunomodulating, antibacterial, therapeutic effect increases the antiviral, antitumor). Use in effectiveness of treatment and helps treatment: viral hepatitis A, B, C, to avoid polypharmacy in bacterial and viral - bacterial pharmacotherapy dysbiosis.

Prisich K.S., Shulga L.I., Beztsenna T.S. STUDY OF THE INFLUENCE OF PHARMACEUTICAL FACTORS IN THE DEVELOPMENT OF DENTAL FUNDS – LIQUID EXTRACT OF BURNET Institute of Pharmacy Professionals Qualification Improvement National University of Pharmacy (Department of General Pharmacy and Safety of drugs) Kharkiv, Ukraine

Actuality. For the treatment of 30% - 70% ethanol and the inflammatory diseases of the oral appropriate concentration of solvent. cavity, justified is the use of herbal Microbiological study was remedies, among which the share of carried out microbiological method liquid extracts is negligible. In the of diffusion in agar on the basis of aspect of the specified relevant are the laboratory of biochemistry and studies on the creation of a new biotechnology SI "Mechnikov product for dentistry, namely, liquid Institute of Microbiology and extract of Burnet. immunology of National Academy of Objective: to determine the Medical Sciences of Ukraine". microbiological screening of the The cultures of influence of auxiliary substances microorganisms from American (extractant), pharmaceutical as an typical collection were used as test- important factor in creating dental strains of cultures: S. aureus АТСС tools – liquid extract of Burnet. 25923, E. coli АТСС 25922, P. Materials and methods aeruginosa АТСС 27853, B. subtilis study. Objects of research: Burnet АТСС 6633, P. vulgaris ATCC 4636, C. rhizomes and roots, model samples albicans АТСС 885-653. of liquid extracts, which are made on

52 ISIC-2016 Abstract book

The results and discussion. Burnet 40-60% ethanol test strain P. After analyzing the results of vulgaris 40% and 50% ethanol, and microbiological screening, it was set, the test strains B. subtilis 50% and that the level of antimicrobial 60% ethanol. Comparing the values activity depends on the of the diameters of zones of growth concentration auxiliary substances – delay of the test strains samples of ethanol. fluid extract of Burnet 60% and 70% The lowest zones of growth ethanol indicated that their retardation of all investigated test- antimicrobial activity hardly differed. cultures of microorganisms were In the future we plan to observed for the samples of liquid conduct several studies to determine extract of Burnet, made the content of biologically active 30% ethanol. substances of learning samples of The highest values of liquid extracts 40%, 50%, 60% diameters of zones of growth delay ethanol for the final selection of the of the test strain of S. aureus was extractant of plant-based observed for samples of extracts of preparation.

Pushkar L., Bondarenko V. THE NEW METHOD OF FORENSIC MEDICAL DIAGNOSTIC OF ACUTE ALCOHOL POISONING Kharkiv National Medical University (Department of Forensic Medicine, Medical Jurisprudences), Kharkiv, Ukraine

Acute alcoholic poisonings of AAP by means of determination of (AAP) have the 1st place in the list of diagnostic value of the sings of AAP fatal poisonings in Ukraine. The and estimation of their total diagnostic of this kind of death is combination. In during of this work difficult because forensic medical we had autopsy of 44 corpse of men expert must reveal and analyse more and woman which died after AAP than 30 diagnostic and non-specific (research group) and 61 corps of signs which also are found in other men and woman (control group) types of death. Now the forensic which died after cardiovascular medical diagnostic of AAP base on diseases and mechanical injuries the subjective rating of this signs without any alcoholic intoxication on without any objective criteria and so, the moment of death. the forensic medical experts commit So, we studied 32 the errors sometimes. macromorphological signs of AAP The purpose of this work which recommended in use by the consist in improvement of diagnostic rules and put their presence or

53 ISIC-2016 Abstract book absence in special registration cards trachea +3.4 and -3.4;the DC of in during of every autopsy. Finally bladder distension, bladder overflow we got the frequency of meeting of with urine +4.1 and -2.4; the DC of every sign in research and control skin cyanosis and face puffiness +3.6 group and by the criterion of and -2.4; the DC of palpebral oedema Student, Kullback's and Gubler- +3.1 and -2.8 DC etc. When we got Genkin's methodology we calculated every DC we must calculate their the diagnostic criterion of every sign combination (sum of DC). If this DC of death. sum put together 30 points or more In result of researching we got the conclusion of cause of death 17 macromorphological signs of AAP (AAP) would be with a probability up which have trustworthiness in to 95 %. If this DC sum less than 30 diagnostic between research and points we must continue own control groups and we calculated the investigation and make the diagnostic coefficient (DC) of every additional laboratory investigations sign and made the special table of (histological, toxicological, recommended diagnostic signs. So, biochemical etc.). the DC of presence of viscous pale Thus, we found out special grey mucus is +3.8 and their absence diagnostics algorithm of the cause of – minus 3.8; the DC of evident death from AAP which based on injection of conjunctiva vessels is frequency of meeting of diagnostic +5.5 and their absence - minus 2.5; signs and which is ready to use in the DC of hyperemia and (or) practice yet. This new method of haemorrhages of mucous membrane diagnostic of AAP increase the of proximal sections of small diagnostic value of expert intestine is +4.2 and -3.4 (absence); conclusions and decrease the the DC of hyperemia of vessels of possibility of errors in forensic mucous membrane in larynx and medical expertise of AAP.

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Sader Abbas, Adeem F.Y., Vasylieva O. THE EFFECT OF CHRONIC ELECTRICAL STIMULATION ON THE MUSCLES PHYSIOLOGICAL PROPERTIES IN PATIENTS WITH MYOTONIC DYSTROPHY TYPE 1 Research Advisor: PhD Marakushin D. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. To date, in Myotonic functional tests (10 Meter Walking Dystrophy type 1 (DM1) the Test, 6 Minutes Walking Test – MWT rehabilitative interventions have and Timed Up and Go Test – TUG always been aimed at muscle test) were performed. We analyzed strengthening, increasing of fatigue the average rectified value of sEMG resistance and improving of aerobic signal amplitude (ARV) to metabolism efficiency whereas the characterize the sarcolemmal electrical membrane fault has always excitability. been addressed pharmacologically. Results. After the treatment an Neuromuscular electrical stimulation increase of muscle strength in those (NMES) is a useful therapeutic tool in DM1 patients with a mild strength sport medicine and in the deficit was observed. In all subjects rehabilitation of many clinical an improvement of 10 MWT was conditions characterized by motor recorded. Five patients improved impairment such as stroke, cerebral their performance in the 6 MWT. In palsy and spinal cord injury. TUG test 4 out of 6 patients showed a The aim of our pilot study slight reduction in execution time. All was to evaluate the effects of chronic patients reported a subjective electrical stimulation both on improvement when walking. A functional and electrical properties complete recovery of the normal of muscle in a small group of DM1 increasing ARV curve was observed patients. in 4 out of 5 DM1 patients; the CM Materials and methods: five patient didn’t show modification of DM1 patients and one patient with the ARV pattern. Congenital Myotonia (CM) Conclusions: NMES performed a home electrical determined a clear-cut improvement stimulation of the tibialis anterior of both the muscular weakness and muscle lasting 15 days with a the sarcolemmal excitability frequency of two daily sessions of alteration in our small group of DM1 60 minutes each. Muscle strength patients. Therefore this was assessed according to the MRC rehabilitative approach, if confirmed scale (Medical Research Council) and by further extensive studies, could be 55

ISIC-2016 Abstract book considered early in the management inhibition of small conductance of muscular impairment in these calcium-activated potassium patients. An attractive hypothesis to channels expressed 3 (SK3) in explain our encouraging result could muscle of DM1 subjects. be represented by a functional

Savelieva E.V., Levasova O.L., Masih T. EFFECTS OF CAFFEINE, ACETAMINOPHEN, CARBAMAZEPINE AND THEIR COMPOSITIONS ON LIPID PEROXIDATION AND STATE OF THE ANTIOXIDANT SYSTEM IN A BLOOD SERUM OF RATS Kharkiv National Medical University Medical and bioorganic chemistry department Kharkov, Ukraine

Actuality. One of the ways to in 2nd group were administered 3% improve traditional medicines is to starch mucus and formalin edema create co-formulated drugs. The drug was caused by subplantar combination in multicomponent introduction of 2% formalin solution composition mutually enhances their in the hind paw of rat. Animals of 9 pharmacological effects; effectively groups were administered the eliminates pain, inflammation, than investigated drugs once orally via each individual component. gastric tube. Animals of the 3rd The aim. Determination of group received paracetamol (6 mg/1 lipid peroxidation (LPO) and state of kg of body weight); 4th –caffeine (0.6 the antioxidant system (AOS) in a mg/1 kg), 5th group – blood serum of rats in carbamazepine (5 mg/1 kg); 6th multicomponent composition group – a combination of compare to mono-preparation in rats carbamazepine (5 mg/1 kg) and under the condition of formalin caffeine (0.6 mg/1 kg); 7th group – a induced edema. combination of carbamazepine (5 Materials and Methods. An mg/1 kg) and paracetamol (6 mg/1 experimental study was performed kg); 8th group – a combination of on 54 rats of WAG line with the paracetamol (6 mg/1 kg) with average weight 210 - 230 g. The caffeine (0.6 mg/1 kg); 9th group – a animals were divided into 9 groups combination of carbamazepine (5 of 6 animals in each group. 3% starch mg/1 kg) with caffeine (0.6 mg/1 kg) mucus was injected orally via gastric and acetaminophen (6 mg/1 kg). tube to intact animals of 1st group (2 Intact animals and animals of ml/200 g of rat weight). The animals 2-9th groups were decapitated under 56

ISIC-2016 Abstract book ether anesthesia after 4 hours after and their composition affect the state modeling formalin induced edema – of CAT, SOD in rat serum and reduce at a time of the maximal edema in 2- it compare to formalin induced 9th groups animals. The serum was edema and even intact animals. Tri- used for investigation of LPO. The component composition of level of primary oxidation products – paracetamol + caffeine + diene conjugates (DC) and secondary carbamazepine brings studied products – malondialdehyde (MDA) parameters close to values of control was determined using a group. spectrophotometric method. Also Conclusions. Consider the this method was used for the results of the CAT and SOD study determination of AOS: the activity of under the condition of formalin catalase (CAT) and superoxide induced edema we can conclude that dismutase (SOD). these values correlate better than Results. All investigated adjusted figures of LPO (DC and drugs reduce the level of DC and TBARS), it indicates that the TBARS statistically significant with composition of caffeine have a strong regard to formalin induced edema antioxidant effect. The experiment and results are relatively close to the results confirm that tri-component control group. The three-component composition paracetamol + caffeine composition (paracetamol + caffeine + carbamazepine is an effective at + carbamazepine) has the best the state of LPO and AOS under the influence on the level of DC in condition of formalin induced edema investigated drugs. The level of and can be recommended for further TBARS is affected by all investigated study. composition. All investigated drugs

T.M. Sazonova, J.G. Zhadan DETERMINATION OF CATALASE ACTIVITY AFTER MODELING CRYONECROSIS OF THE MYOCARDIUM IN RATS Scientific advisors: S.I. Panov, Associate Professor of the Department of Human Anatomy S.A. Sherstuk, MD, Professor, Head of the Department of Human Anatomy V. N. Karazin Kharkiv National University, Medical faculty, Department of Human Anatomy

Relevance. 50 thousand of is one of the forms of necrosis of the new cases of myocardial infarction myocardium caused by violation of are recorded each year in our the blood flow through the affected country. Myocardial infarction (MI) - arteries. 57

ISIC-2016 Abstract book

High mortality and lack of pneumothorax. Cryogenic heart accurate repeatability of heart treatment was produced by damage, using existing models of MI, cryoinstrument with surface encourages researchers to look for temperature of the applicator -196 ° new options of modeling MI, which C. Chest cavity was tightly sutured will help to standardize the affected after cryoablation of the heart. area. Catalase activity was Formation of myocardial determined by a method based on damage is accompanied by intense the ability of hydrogen peroxide formation of active forms of oxygen (H2O2) to form a stable colored in the heart. Catalase plays an complex with molybdenum salts. 2 important role in limiting their effect ml of 0,03% H2O2 solution was added on cardiomyocytes. Catalase – is an to 0,02 ml of the serum or tissue enzyme of oxidoreductases class, homogenate. 1 ml of a 4% solution of which takes part in the antioxidant ammonium molybdate was added in system of cells and serves as 10 minutes. The optical density of antiperoxide protection. samples was determined by Characteristics of the spectrophotometer SF-46 at a functioning of this enzyme, namely wavelength of 410 nm. its activity, after cryonecrosis of the Results. Determination of myocardium have not been catalase activity in the blood serum established conclusively. of rats on the 7th, 14th, 28th days after Aim. To model myocardial the cryogenic treatment showed a infarction in rats by local dosed decrease of this parameter on 8.3%, cryotherapy on the heart muscle, to 12.88% and 13.43% respectively, at determine the activity of catalase p ≤ 0,01, relative to the norm. after modeling cryonecrosis. Conclusion. The decrease of Materials and methods. catalase activity in blood serum of Experiments were carried out in 10 rats on the 7th, 14th and 28th days mongrel male rats. MI model was after modeling cryonecrosis of the created surgically on animals under myocardium showed intense the ether mask narcosis. Before processes of lipid peroxidation. opening the chest cavity, a four-point These findings can be used to four ligatures were tied around 5th develop new methods of treatment and 6th ribs, that maximally helped of necrotic changes in the to exclude the development of myocardium.

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Sharapova A.E. FUNCTIONAL FEATURES OF THE AMYGDALA Research Advisor: Assistant Bausova O.B. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. One of the current hypothalamus area, while the issues of physiology of the human basolateral complex – on the central nervous system is not fully parasympathetic one. The amygdala, studied functional features of some especially its basolateral part, is structures, particularly of the limbic characterized by presence of a great system. A lot of functions of this number of glucocorticoid receptors system are performed due to such and therefore is sensitive to stress. It subcortical structures as the is assumed that such conditions as amygdalae. As it has been proved restlessness, autism, depression, that the loss of activity and posttraumatic shock and phobias are communications of the amygdalae associated with abnormal function of neurons leads to appearance of a the amygdala. Besides, weak number of pathologies, thus, the goal stimulation of basolateral part of the of the research consists in obtaining amygdala leads to improving of of accurate and extensive knowledge quality of short-term memory concerning amygdala functions, what processes, especially when initial is necessary for the further use of it level of memorizing is low. in clinical practice. Corticomedial region of the Materials and Methods: amygdala, as the part of the lateral Clinical research, observations and olfactory area, is functionally statistical regularities, based on associated with perception of smells them, have served as the basis for and regulation of sexual behavior. the study of functional features of the Additionally, it is responsible for amygdalae. creating reactions of avoiding of Results. In particular, the aversive stimuli. Excitation of this effects of stimulation amygdala were region can cause sexual activity. defined. Mostly they are caused by Conclusions: The amygdala its wide connections. Generally, plays an important role in formation stimulation of the amygdala can of subjective feeling of fear and cause almost all the effects appearing autonomic response of organism to it in stimulation of the hypothalamus. due to expression of the stathmin What is more, the corticomedial protein in the neurons of lateral complex of the amygdala has greater amygdala nuclei. Inability to feel fear effect on the sympathetic is one of the symptoms of amygdalae 59

ISIC-2016 Abstract book lesion, for example, of Urbach- pathologies as drug addiction, Wiethe syndrome. The size and schizophrenia, Alzheimer’s disease number of connections of the and epilepsy.Thus, it’s worth amygdala can be potential mentioning that the functions of the biomarkers for detection of groups amygdala are important and various of people who are predisposed to and its functional disorders are anxiety disorders. Besides, changes involved into the pathogenesis of in volume, number of connections many diseases, that is necessary to and electrical activity of the be considered in the diagnosis. amygdalae are signs of such

Sharapova A.E., Bausova O.B. INTERSYSTEM RELATIONS OF CARDIORESPIRATORY SYSTEM IN MEDICAL STUDENTS DURING THE STUDYING IN UNIVERSITY Research Advisor: PhD, Associate Professor. Chernobay L.V. Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Materials and Methods. The conjugation index (Hildebrand test, functional parameters of the normal value 2.8-4.9) as the ratio of cardiovascular and respiratory the heart rate and respiratory rate, systems and their relations in which characterizes the strength of condition of the dynamical psycho- the intersystem integration. emotional stress in medical students It was revealed that the after a year of studying in university presented physical activity caused (experimental group) were different types of reactions of the investigated. cardiovascular system in students of Results. The body condition the control and experimental groups. was evaluated during relative rest The first type of reaction is and immediately after physical manifested by increasing of systolic activity, which was to perform the blood pressure (SBP) on 20 mm Hg work on the cycle ergometer with relative to the initial level, which was constant power in 200W and a conditionally designated as frequency of rotation in 60 Hz "to "normally reactive". The second type failure". Intersystem relations of the of reaction is characterized by SBP cardiovascular and respiratory changes of more than 20 mm Hg, systems were evalua1ted on the which was designated as "over- basis of the calculation of reactive". The third type of reaction 60

ISIC-2016 Abstract book is characterized by the absence of lowest conjugation index, which is changes in SBP or even by equal to 3.48. decreasing of it, and therefore was Conclusions. By the end of the defined as "weakly reactive". first year of studying in university Conjugation index in "over- conjugation index of all three groups reactive" and "normally reactive" tends to decrease, both at rest and types during the rest and during during exercise. These changes are exercise is similar and equal to 4.37 mostly expressed in "weakly and 4.67, respectively. Apparently, reactive" group. It is a sign of the the increased activity of the decreasing of level of intersystem cardiovascular system in these integration of the cardiovascular and students is accompanied by adequate respiratory systems, which leads to activation of the respiratory system. deterioration of the adaptive The "weakly reactive" type has the capacity of the organism in the test conditions.

Shcholok T., Kukushkina M. THE POSSIBILITY OF CORRECTING OF ELASTIN SYNTHESIS IN BLOOD VESSELS Research Advisor: PhD, Associate Professor Gorbach T. Department of Biochemistry Kharkiv National Medical University Kharkiv, Ukraine

Actuality: There is lack of blood vessels of descendants, and to information about the impact of explore the possibility of correcting parental smoking on fetal vessels in the elasticity of blood vessels under literature. At the same time, the fact the influence of dosed physical of placental permeability for most activity. toxic components of tobacco smoke Materials and methods. and their accumulation in the Experiments were conducted on 3- amniotic fluid is observed. In this month-old rats of Wistar lines. Rats regard, studying the effect of were divided into 4 groups: 1) smoking of parents on fetal vessels is control (C), 2) "smoked" only extremely important. females (F), 3) "smoked" females and The aim of our study was to males (FM) 4) "smoked" only males investigate the influence of (M). "smoking" rats-parents on the Modeling of passive smoking was content of collagen and elastin in carried out by placing rats in a 61

ISIC-2016 Abstract book specially designed chamber, which arteries in neonates and 2-month-old was distributed with tobacco smoke offspring of parents-"smokers", what from cigarettes "Pryluky". 1-month- can cause increased rigidity of blood old rats-hairs were placed in vessels, especially if both parents "squirrel wheel" and ran it for 30 smoke. Under the influence of minutes every day. At the age of 2 physical activity the content of months all rats were removed from elastin significantly increased both in the experiment. The amount of the aorta and in the femoral artery, elastin in vascular homogenates was what leads to a decreasing measured using immunoassay with (approaching the level of control) of reagents of Bender - med System ratio of collagen/elastin in vessels. firm (Austria), collagen – with Conclusions. Physical activity spectrophotometric method (for can be recommended as a factor of oxyproline). the correction of functional state of The results of the research. blood vessels in children, offspring of Reduction of elastin was discovered parents who smoke. both in the aorta and femoral

Shenger S.V., Bulynina O.D. FEATURES OF MANIFESTATION OF COMMUNICATIVE ABILITIES AMONG YOUNG PERSONS WITH DIFFERENT TYPES OF FUNCTIONAL ASSYMETRY Department of Physiology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Under the influence would be available to each patient. of scientific revolution and changes, Organizational abilities include: which are connected to the country`s ability of planning own`s activities, movement to the market economy, capacity for work and flexibleness, professional activity of people was fast reaction on changing of plans. significantly complicated in all the We should note that there isn`t any fields, direct losses from the lack of conception in understanding organization or through unused doctor`s abilities and research work abilities increased. So, organizational is taken only in separate questions of activity of the leader acquires big this problem. sense, especially in profession of the The Aim: reveal possible doctor. We should organize the dependence between type of medical work so that specialized and functional asymmetry and hightechnological doctoral help 62

ISIC-2016 Abstract book organizational abilities of KNMU`s – high level of organizational abilities students. (0.71 – 0.80): distinguish + Materials and methods: the 33.3%.We determine that I – low 54 students of KNMU 2 course have level of organizational abilities ( 0.20 been examined. Control group – 0.55) have LTFA. 28.6% RTFA; includes 21 persons with a right type 25% LTFA; 37.5% MTFA and 23.1% of functional asymmetry (RTFA). SMTA. We should note that V – very Comparison group consists of high level of organizational abilities individuals with a left type of (0.81 – 1) have: 9.5% RTFA; 50% functional asymmetry (LTFA) – 12 LTFA and 38.5% SMTA. There isn`t persons, a person with mixed type of anyone with very high level of functional asymmetry (MTFA) – 8 organizational abilities among people and those with socio- persons with MTFA.So, many modified type of asymmetry (SMTA) persons with MTFA have low level of – 13 persons. Organizational abilities organizational abilities (37.5%) and were valued by the test (Sinyavsky a lot of persons with LTFA have very V.V., Fedoryshyn V.A.) high level of organizational abilities Results: We determine that (50%). persons with RTFA, MTFA and SMTA Conclusion: 1. Persons with have III – moderate level of LTFA have IV– high level of organizational abilities (0.66 – 0.70): organizational abilities (0.8). Persons they aspire to have new contacts with RTFA, MTFA and SMTA have III with people, don`t limit the circle of – moderate level of organizational acquaintances, defend their abilities (0.6). positions, plan work in advance, but 2. Many persons with MTFA have the potential of their abilities don`t low level of organizational abilities distinguish high stability, so (37.5%) and many persons with organizational abilities should LTFA have very high level of develop and improve. We should organizational abilities (50%) note that persons with LTFA have IV

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Shubina M.V. APPLICATION OF A CANCER DRUG FOR NEW INDICATIONS - TREATMENT OF NEURODEGENERATIVE DISEASES OF THE CNS Research advisor: Karnaukh E. V., PhD, Candidate Medical of Sciences Department of Pharmacology and medical Prescription Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Nilotinib is a of movement disorders). 6-month proven and approved drug that is treatment with increasing doses of prescribed to people with signs of nilotinib (from 150 to 300 mg per leukemia. Nilotinib is issued by day) may be the first effective brand: NOVARTIS PHARMA AG method for reducing degradation of (Switzerland) named Tasigna. cognitive and motor functions of Aim. Nilotinib may be a very patients with neurodegenerative powerful means for the control of diseases such as Parkinson's disease. motor symptoms among people with Improvements have been colossal: Parkinson's disease by improving the ability to move restores, with the their function and controlling non- help of a walker, take care of motor symptoms of the disease. themselves, speech recovers in a Matherials and methods. I previously non-verbal patients. In studied scientific works Fernando 90% of patients had significant Pagan - author of the study and improvement of clinical parameters, director of the Program movement and concentrations of biomarkers in disorders Georgetown University the cerebrospinal fluid of Medical Center, USA. The study Parkinson's disease (alpha- found that levels of toxic proteins in synuclein, beta amyloid-40/42, and blood and spinal fluid decreased dopamine), general rates of Tau once patients began taking nilotinib. protein and p-Tau (as a Also, tests showed that the manifestation of dementia markers). symptoms of Parkinson's including The tested doses of nilotinib were tremor and "freezing" decreased. significantly lower than the doses And during the study patients were used in treatment of cancer (up to able to use lower doses of 800 mg per day). The drug is proved Parkinson's drugs, suggesting that effective, the research carried for a the brain cells that produce group of people without the dopamine were working better. involvement of control groups. Results. New study by Conclusions. If effectiveness of Georgetown University Medical the drug wiil confirmed in larger, Center, USA, demonstrated it placebo-controlled studies, nilotinib (Fernando Pagan is author of the could become the first treatment that study and director of the Programme interrupt a process which kills brain 64

ISIC-2016 Abstract book cells in Parkinson's disease and other including Alzheimer's disease. neurodegenerative diseases,

Stupnytskyi Myroslav Andrew POSTTRAUMATIC COAGULOPATHY IN PATIENTS WITH THE SEVERE COMBINED THORACIC TRAUMA. Research advisor: Zhukov Victor Ivan Sc.Dr. Med., Sc.Dr. Biol. Biochemistry department Kharkiv National Medical University, Kharkiv, Ukraine

Introduction. Thoracic trauma Naphthol test were used for is one of the leading causes of coagulation monitoring. morbidity and mortality in Results. Reliable decrease of developing countries. Coagulation is fibrinogen concentration in an integral part of inflammation and comparison with control group was widespread activation of coagulation found on the 1-2-d day after trauma results in the systemic inflammatory in both survivors and nonsurvivors. response syndrome and increased Further analysis showed that on the susceptibility to sepsis. 3-4-th day of posttraumatic period Aim. The aim of this study was the level of fibrinogen concentration to determine the diagnostic value of continue decrease in comparison to the coagulopathy markers for control group. The more expressed metabolic monitoring of the severe level of decrease on the 5-6-th day combined thoracic trauma and it’s was for survivors. possibly of outcome prediction. The level of the prothrombin Materials and methods. 73 time increase was on 10.41% for the male patients aged from 20 to 68 1-2-d day, on 7.89% for the 3-4-th with the severe blunt combined day and on 10.15% for the 5-6-th day thoracic trauma with after trauma for patients from pneumothoraxes, hemothoraxes, survivor group. It’s dynamic in lung contusions, heart contusions patients from nonsurvivors group and multiply rib fractures were characterized by gradual increase included in this study. Patients' from the 1-2-d day. examinations were performed on 1- There were significant 2-d, 3-4-th and 5-6-th day after correlations between prothrombin trauma. The prothrombin time, time estimated on 1-2-d day after fibrinogen concentration and β- trauma and objective scales that characterise patient’s status on 65

ISIC-2016 Abstract book admission RTS scale and TRISS Conclusions. Hypocoagulation probability. Less significant occurs early from the 1-2-d day of correlations were between trauma in equal extent for both fibrinogen concentration on 1-2-d groups of patients with the severe day and these trauma objective combined thoracic trauma. scales. Coagulation abnormalities are the There were significant result of vital functions disturbances differences in β-Naphthol test on 1- (the level of traumatic shock) rather 2-d and 5-6-th days after trauma than direct mechanical tissue injury. between two groups of patient, more Disseminated intravascular expressed on 5-6-th day. Appearance coagulation with a fibrinolytic of positive and strongly positive β- phenotype at an early phase of Naphthol test on 5-6-th day after trauma is the predominant and trauma increases probable mortality initiative pathogenesis of trauma- from 18.47 – 19.37% to 26.91 – related coagulopathy with maximal 28.08%. expression on 5-6-th day of posttraumatic period.

Sukhonosov R., Vovk O., Ikramov V., Shmargalev A., Shafranetskaya V. THE CRANIOMETRY OF THE SKULL VAULT AT ADULT PEOPLE Research advisor: Tereshenko A., Professor Human anatomy, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The vault of skull The aim of research is (fornix) is the roof of the head and determine a range of main linear brain, brain forming protection and parameters of vault of skull at adult vital structures located there in. A people, from the standpoint of the number of authors studied the doctrine of individual anatomical characteristics of the structure of the variability. The study carried out on skull, its bone formation, considered 40 specimens of skulls of adults in the age and the individual aspects, using conventional techniques of will highlight a science – craniology. craniometric researches. We should not forget that the cranial Matherials and methods. The vault is the main field for surgical vault of skull has a pronounced approaches to different parts of the longitudinal range of parameters in brain, in which are carried out and a adults. So, the main length of the burr hole formed the necessary cranial vault corresponds to the different shapes and sizes. length of the skull and the distance 66

ISIC-2016 Abstract book between two craniometric points: gl vault in male from 18.0 to 19.5 cm (glabella) and op (opistocranion). (l= 18.87 cm, σ = 0.628, m = 0.170) This parameter ranges from adult and in female: the range from 17.0- males from 17.0 to 19.5 cm, making 17.5 (l= 17.22 cm, σ = 0.630, m = the amplitude variation of 2.5 cm; in 0.168), variants having the female – from 16.2 to 17.5 cm with amplitude of 1.5 and 0.5 cm, amplitude of 1.3 cm lengths. respectively. This indicates a Results. It was found that in the genetically reasonable relationship brachimorph shape of the skull gradually increasing the longitudinal length cranial vault varies from 17.0 setting of the cranial vault from to 17.9 cm (l =17.37 cm, σ = 0.545, m brachimorph to meso- and = 0.198) in men and l = 16.56 cm, σ = dolichomorph. 0.5620, m = 0.185 – for women, Conclusions. The study while there is a variation of the established a range of basic amplitude of 0.7-0.9 cm when morphometric parameters of the mesomorph form range of the cranial vault with a predominance of parameter of the cranial vault does all parameters in males. It defines not exceed 17,8-18,3 cm (l =17.98 the expression the dependence of the cm, σ = 0.385, m = 0.115) in men and longitudinal parameters of the 16.7-17.2 cm (l = 16.95 cm, σ = cranial vault on the type of structure 0.411, m = 0.121) in female and of the head, with their progressive forms amplitude variation within a increase from brachimorph to 0.5 cm in both genders. Accordingly, dolichomorph. The statistical in the dolichomorph form set range analysis revealed laws, confirming of variability of the length of the their importance.

Tarasenko D. THE INFLUENCE OF BLOOD GROUP ON THE FORMATION OF HUMAN CHARACTER Research advisor: Vashchuk N., Associate Professor, Candidate of Medical Sciences Department of normal human physiology, Kharkiv National Medical University, Kharkiv , Ukraine

Actuality. Blood is a liquid and does not allow non-resident loose connective tissue, with agents adversely affect us. We different for all organisms. It touched on this problem, in our performs two vital functions: opinion related with blood, as the saturates the body with nutrients formation of character for a single 67

ISIC-2016 Abstract book person or group of people. After all, university and familiar people, the nature of this phenotype painting whose qualities are well known. The temperament, inherited with the group of respondents was 115 blood of our parents. We are persons, among them to the I(0) interested in the theory of Polish group belonged47 people, to II(A) - scientist Ludwig Hirstsfeld, which 37, III(B) - 24, and IV(AB) - 7. states that ancient people are The results of the research. belonged for only one group of Those with I(0) blood group was blood, in AB(0) group system – the characterized by such features: high first group. The cause of the sociable, conscientious, optimism, mutation were turning points of vain, sometimes egocentric, human history. So, almost ancient ambitious, rude andjealous. For people were obtaining food by group II(A) blood were markedly hunting other animals, and the name different, this group had such of their group of blood is “Hunters”. qualities: balanced, commitment, Due to life on one place and respectable, responsible, dispirited, consumption of mainly vegetable excessive seriousness, obstinate and food their blood again mutated, we skeptical. III(B) group had the know it as the second group - following results: charismatic, "Farmers". People noticed that in talented, spirited, irresponsible, different places they could take more selfish, immature and unpredictable. harvest, as well as animals run away IV(AB) had such indicators: cool, from human habitat and began move expedience, talkative, chaste, from place to place in order to find a excessive strictness towards others, better place, so, we got another lack of initiative, indecisive and specific composition of blood - the inattentive. Our observation is third group – “Nomads”. As time almost coincided with the research passed, humanity took a new of Japanese scientists and may form territory, races were mixed blood the basis for the proper formation of with each other, and new kind of character and raise a man's strengths blood appeared – the firth, at the and weaknesses compensation. In moment the youngest group. this way we will be able to rationally Japanese researchers have distribute the load as the children supported the Herstsfeld’s theory during their maturation, to facilitate and suggested that each group of training for a separate group of blood will specifically affect blood, preventing the causes of temperament of the person. stress, which will contribute to an Materials and methods of increase in their psychological and research. We decided to conduct the emotional stability, health and research on our colleagues in the human well-being.

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Terletska Yevhenia Olexandrivna, Boyko Kateryna Olexandrivna THE EVALUATION OF QUALITY OF LIFE OF YOUTH DIFFERENT LEVELS OF PHYSICAL PERFORMANCE Research advisor: candidate of Medical Sciences Nazarko Nataliya Mykolaivna Department of Physical Rehabilitation and Sport Medicine Bogomolets National Medical University Kiev, Ukraine

Actuality: A research of the evaluation of the quality of life, were quality of life is very important used. component to identify health state Results: Using methodology, now. The process of poll holding is which was created by Multinational not very difficult. Therefore, there center of evaluation of the quality of are many different methods to life, a significant difference evaluate a quality of life. However, comparing indexes of emotional role this problem is not studied enough. functioning and general health Which one is the most effective, perceptions (p<0,05) between the relevant and the most accurately groups with different levels of demonstrate problem of the quality physical performance were found. A of life. significant difference was found Aim: To compare methodology comparing indexes of general health of evaluation of the quality of life, perceptions, vitality, social role prepared by “Evidence Clinical and functioning, bodily pain (p<0,001). Pharmaceutical Research” and Also a significant difference was methodology prepared by found comparing emotional role Multinational center of evaluation of functioning and mental health the quality of life. (p<0,05) using a methodology of the Materials and methods: quality of life research, prepared by There were 136 students (21±0,3 “Evidence Clinical and years old) of Bogomolets National Pharmaceutical Research”. medical University inquired during Conclusions: Methodology of this research. Physical performance evaluation of the quality of life were assessed by a national standard prepared by Multinational center of (Patent UA 34351 A) and a quality of evaluation of the quality of life life were assesed by SF-36 health requires less time and data, but it survey. For the evaluation a gives less reliable results. methodology, prepared by “Evidence Methodology of evaluation of the Clinical and Pharmaceutical quality of life prepared by “Evidence Research” and a methodology, Clinical and Pharmaceutical created by Multinational center of Research”, needs more time and 69

ISIC-2016 Abstract book resources, but it gives more possible and reliable results.

Tokareva I.l. MEDICAL RESEARCH IN METROLOGY Kharkiv National Medical University, Research Department.

Measurements in medicine is Medical device - a technical quite specific, so metrology allocated device that allows you to create the a separate direction - medical energy impact of therapeutic, metrology. Medical Metrology - surgical or bactericidal properties, as Metrology direction, whose main well as providing medical purposes task is to ensure the unity and defined composition of various reliability of measurements in substances (unit UHF-therapy, medicine. Research in the field of electrosurgery, the suit sstvennoy health metrics, benchmarks are kidney, ear prostheses, surgical conducted within the medical apparatus and equipment operating, metrology, samples, etc. These therapeutic types of devices using medical metrology used in medical various types of radiation, etc.). information systems Conclusions The metrological Technical devices used in requirements for medical devices are medicine, called the generalized term quite obvious. Many medical devices "medical equipment". Most of the are designed to provide energy medical equipment related to metering effect on the body, so they medical equipment, which in turn is deserve the attention of the divided into medical devices and metrological service. medical devices. The Law of Ukraine "On Objective metrology and metrological activity" To analyze the existing types of in the new edition of the medical equipment, and to consider 15.01 2015 defines the legal their metrological assurance framework for ensuring the for the correctapplication in uniformity of measurements in scientific research. Ukraine, regulates public relations in Results. The medical device is the sphere D metrology, aimed at considered to be a technical device protecting the citizens and the intended for diagnostic or national economy from the therapeutic measurement (medical consequences of doubtful results of thermometer, measurements. sfigmomanom emp, electrocardiogra When the research should be ph, etc..). guided by the requirements of the Act, only in this case and ssledovatel

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ISIC-2016 Abstract book can be sure that the results of him in the course of work, are experimental studies, obtained by reliable and reproducible.

Tokareva Il SYSTEM METROLOGICHETION PROVIDE MEDICAL EQUIPMENT IN HEALTH CARE Kharkiv National Medical University, Research Department

Actuality. Modern medicine used measuring devices, graphs of has a huge amount of measuring power metal ki and their timely instruments: from elementary execution, assigning responsibility thermometers for measuring body for metrological provision of medical temperature, blood pressure institutions - important licensing monitors, scales up devices for terms medical facility. The Law of ultrasound, Ukraine "On metrology and computed tomography, etc... metrological activity" operating in The accuracy of their readings the country since 1998 (revised depend correct diagnosis and from 15.01. 2015) It regulates the effectiveness of treatment prescribed relations of which arise in the by a doctor. Not by chance, in the process of e metrology measurement, which are used in Starting the implementation of medicine and public health, fall research, fulfilling the requirements within the scope of state regulation of the Law of Ukraine "On metrology of ensuring the uniformity of and metrological activity" should be measurements. aware of dissertation: measuring Purpose - analysis of equipment for medical purposes, metrological provision of measuring used in scientific research, should be instruments for medical purposes in metrologically believed territorial the health sector based on the study center of standardization, metrology of normative legal acts of and certification, and have the the legislation of Ukraine. testimony of Mr. metrolo nical Results. The need for verification. Verification is carried verification of measuring out once a year. Work on unverified instruments used in the medical devices is strictly prohibited; organizations - is one of the Pilot studies should be carried components, guaranteeing and out in laboratories accredited by the certifying the quality of medical Ministry of Health of Ukraine, to the services provided by the agency. Of right of measuring work and have course, this contributes to the fact the corresponding certificate. that the existence of an agreed list of

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Conclusions. Fulfilling the results of experimental research, requirements of the Act of obtainings them in the process, will dissertation can be sure that the be accurate and reproducible.

Topchii S.V., Izmailova L.V. STRUCTURAL ORGANIZATION OF NERVES OF THE SUPERFICIAL TEMPORAL AND FACIAL ARTERIES Research Advisor: PhD, Associate Professor Kulish A.S. Department of Human Anatomy Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Nervous system of neurovascular complexes stained vessels, in particular arteries, has according to methods of Weigert Pal attracted the attention of the and Krutsau were studied. morphologists and clinicians for a Results: Macromicroscopic long time. Currently, in addition to preparation methods using a practical requests of agiosurgions, binocular microscope revealed that accurate data on the structural sources of the adventitial nerve organization of the nervous plexuses of the superficial temporal apparatus of adventitial plexuses of and facial arteries are branches of arteries are of great theoretical value the superior cervical ganglion of the for a more complete understanding sympathetic trunk and branches of of the nerve supply of each organ. the facial, trigeminal, vagus and The aim of this study was to glossopharyngeal nerves. Studying clarify the sources of nerve histograms of neurovascular periarterial plexuses of superficial complexes of the superficial temporal and facial arteries, quantify temporal and facial arteries showed the structural organization of myelin that their adventitial plexuses nerve component constituting their forming nerve trunks of various adventitial plexuses. sizes. Thus, adventitia of the Materials and Methods: The temporal artery of the newborn in its study was conducted by proximal part the number of trunks conventional and macromicroscopic ranges from 3 to 8, in adulthood - and gistotopographic methods. from 7 to 15. The adventitia of the Complex modern morphological facial artery has from 2 to 5 trunks, methods were used to obtain data on in newborns, in adulthood - from 5 to the structural organization of the 12. The nerves of newborn they are nerves. Cross-sections of the represented only by thin (1-3mkm) 72

ISIC-2016 Abstract book fibers. In adulthood, the spectrum of branches of the superior cervical myelin fibers is mainly represented ganglion of the sympathetic trunk, by fine fibers, their content is 82- the branches of the facial, trigeminal, 85%, the content of the medium- glossopharyngeal and vagus nerves. sized fibres (diameter 3-7mkm) - 7- The nerve plexuses in the adventitia 11%, and thick ones (7-10mkm) - 5- of the superficial temporal and facial 9%. The total number of myelin arteries are formed by component in the nerves of the macroscopically visible as well as by superficial temporal artery in microscopic nerves with diameter newborns was 9 ± 3,3, in middle age less than 70 microns. Quantitative - 56 ± 11,8. In the nerves of the and qualitative data of myelin fibers adventitial plexus of the facial artery in the nerves of adventitial plexuses in newborns total number of myelin of studied arteries vary according to fibers was 7 ± 1,8, while in adulthood the age and the widths of studied - 37 ± 9,6. vessels. Conclusion: Thus, the main sources of studied plexuses are

Tsimokh I., Zhuravleva P. СOMPLEX GENETIC DISORDERS Research advisor: Shmulich O.,Candidate of Biological sciencis Department of Medical biology, Kharkiv National Medical University, Kharkiv, Ukraine

Introduction. The problem of diseases make 94% of all human studying genetic mechanisms of diseases. predisposition to diseases, The aim of our research is to inheritance of which does not fall determine influence of the under the Mendel’s rules and depend environmental factors and genetic on a significant number of genes predisposition on diabetes mellitus with additive effect (genetic development. component) and on the Material and methods. The environmental factors research method is data collection (environmental component) is one of from the controlled group of 46 the less examined. persons, among whom were sick and The actuality of this problem healthy people of different ages. Data solving lies in the fact that on the collection took place over several modern stage the multifactor days.

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The group under research the carbohydrate metabolism: consisted of mono- and dizygotic caffeine, adrenalin etc., previous twins, 19 persons with genetic infectious diseases: smallpox, predisposition and influence of German measles etc.) significantly internal and external factors, 15 with intensify activity of genes with the influence of factors but without additive effect, genetic predisposition, 8 with 4) Availability of unfavorable predisposition but without influence external environmental factors of factors. (stresses, constantly changeable Results. The research has environmental conditions, shown that disease was manifested professional load etc.) strongly by the influence of various factors on influence in case of availability of people who have no genetic genetic predisposition of a person, predisposition. But observing certain 5) 5.2% of persons without rules group with a genetic genetic predisposition but with predisposition has avoided diseases. influence of various factors the The conclusion. On the basis of disease was revealed, data, collected from this group such 6) Concordance in monozygotic conclusions were made: twins is pronounced greater than in 1) Susceptibility is the higher, dizygotic twins, the higher level of environmental 7) The higher the degree of factors is, because relatives have one severity in relatives of proband, the and the same habitat, severer disease appears, 2) Risk for relatives of proband 8) Under similar external depends on the relation degree – factors the type II diabetes appears disease frequency decreases under more quickly. decrease of the relation degree, Determination of influence of 3) Internal factors (low-activity various factors on development of mode of life, improper feeding, multifactor disease is important for susceptibility to overeating and the modern medicine for provision of obesity, intensity of pancreas work, early and rational disease treatment taking preparations that influence on and prophylaxis.

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Vdovychenko E., Klimchuk O. ANATOMIC-FUNCTIONAL CHARACTERISTICS OF THE LOWER LIMB JOINTS IN CASES OF FLAT-FOOTEDNESS Research Advisor: Doctor of medicine, professor Fomina L.V. Department of normal anatomy Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Human loco-motor degree of flat-footedness, 4 persons system plays a key role in life of a had the 2nd degree of flat-footedness person, because in case of loco- and 2 young men had the 3rd degree. motor system disorder not only does The record of the low limb angles the quality of life suffer some was performed against the changes but it also affects the anatomical axis in the frontal plane. functioning of inward parts of a From this point on we performed the body. For efficient axial load evaluations of the relationship of the redistribution, lower limb joints changes in the coxofemoral joint to form angles against long axis of the the degree of flat-footedness. body. In case of the abnormality of Findings of the research: one angle curve it may lead to According to Y. Zhuravlyov ( 2012 ) pathological changes of other angles. the normal arch height of the foot As a general rule, in prospect it may equals to >35mm, and the angle of lead not only to the development of the longitudinal arch of the foot the limb supporting function equals to 128◦ ± 2◦. According to our insufficiency but also to some results, the arch height of the foot structural changes in epiphysis of the among 5 young men with no flat- bones, in particular, the head of footedness averaged to 38mm with femur. the angle of 129.7◦. Their proximal The aim: to find out the anatomic angle of the femoral bone ( relationship of the anatomic- hereafter as PAA ) varied from 84.8◦ functional changes in the to 86.9◦ and their cervical-diaphyseal coxofemoral joint to the degree of angle ( hereafter as CDA ) varied flat-footedness. from 130.4◦ to 132.2◦. In case of 1st Materials and methods: 15 degree of flat-footedness the PAA young men of the military service observed among the young men age group were observed during the varied from 87.1◦ to 91.7◦ and the research. Among 5 of them there was CDA varied from 134.7◦ to 141.9◦. no flat-footedness observed but the Cosmetic disability in a form of club rest 10 people were evaluated with foot was observed among the young some pathological changes, as men. In case of 2nd degree of flat- follows: 4 young men had the 1st footedness the PAA observed among 75

ISIC-2016 Abstract book the young men varied from 93.7◦ to Conclusion: Untreated flat- 100.2◦ and the CDA varied from 145◦ footedness, which leads to the to 155◦. In case of 3rd degree of flat- changes in the angles of the footedness the PAA observed among coxofemoral joint, in the future may the young men varied from 102.2◦ to lead to early sclerotic changes in it 102.8◦ and the CDA varied from that may appear as a result of 158.1◦ to 159◦.In cases of the 2nd excessive stretch of the band in the and 3rd degree of flat-footedness the femoral head that promotes its young men complained of the pain in nutritional disorder. coxofemoral joint, specifically during long-lasting physical-activity.

Yuncova K.O., Yurkina I.S., Kolisnik I.L. AGE-RELATED CHANGES IN VESSELS OF ADRENAL GLANDS Research advisor: Korobchanska A.B. Department of human anatomy, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. In order to study of upper adrenal artery transforms into age-related changes in vessels diaphragmatic artery. This vessel is studied 50objects of different ages. not located on adrenal gland, and Adrenal arteries of fetus and above its upper margin and goes newborn wide, but trunks are short, with its main trunk to diaphragm, thereby adrenal glands little mobile sending to adrenal gland lateral and closely are adjacent to kidney, branches. Thus, in adult, unlike of diaphragm and aorta. With age, fetus and newborn, there is not one caliber of adrenal arteries relatively upper adrenal artery, but few small reduces, and length increases, glands branches. become more mobile and a layer of Branches of adrenal arteries fat separates from above-mentioned are located on the gland superficially organs. and loosely in fetus and newborn, as Relationships changes acutely an adult, they are immersed in with age, between upper adrenal substance of organ, tightly accrete artery and gland. Upper adrenal with stroma. Adrenal artery of fetus artery of fetus and newborn and newborn splits on capillaries presented by separated trunk, which subcapsulary, and in adult, in is located on surface of organ. Along thickness of organ. with development of diaphragm and In adult thereby division of adrenal increasing of its functional load gland by connective strands into 76

ISIC-2016 Abstract book particular lobules and some parts, Capillary network of adrenal intraorganic vascular network of glands in adult becomes less dense cortical part acquires certain and it is not marked independent isolation. capillary networks corresponding to The capillaries of adrenal different zones of cortical substance. glands of fetus and newborn do not In fetus and newborn is only have an independent form, one way of outflow from the gland - presented by slits that repeat space central vein. In adult except central between cells, their walls are vein on surface of organ there are extremely thin. With age capillaries several thin veins, their number and of adrenal glands becomes clear caliber is not constant. outline and compactness.

Zaporozhchenko Y. S., Maslova N. M. INFLUENCE OF MILD EMOTIONAL STRESS ON THE HEART RATE Research advisor: Department of Normal Physiology, Kharkiv National Medical University, Kharkiv, Ukraine

Relevance. Emotional stress is sympathetic and parasympathetic a state of explicit emotional nervous systems during emotional experiences of sudden difficulties of stress are required. The circulatory life, the inclusion of non-specific system has a high reactivity and adaptive mechanisms due to the plays a crucial role in the adaptation pathogenic effects of the reconstructions of the physiological environment, extreme force or state of the organism.( Tkachev V. I., prolonged negative emotions (Isaev Nadezhkina E. Yu., Filimonov O., D. N.) It is of great importance, 2015) Increase of heart rate during because it is the basis of many emotional stress is due to the physiological coping responses, influence of the sympathetic nervous which allow to overcome conflicts, system. The decrease of heart rate personal fears and anxieties. It is also during emotional stress is due to the important that the manifestations of action of the parasympathetic stress in students (fear of exam, etc.) nervous system ( Y. V. Shcherbatykh, can have a crucial effect on all body 2000) systems: nervous, immune, Aim. The determination of the cardiovascular and others. influence of mild emotional stress on Therefore, the study and the the heart rate among the students. knowledge of changes of the 77

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Method. We undertook a study minute also 15%. In groups with low of 56 students in 4 groups of 4 performance the heart rate is faculties. To assess the reactivity of elevated in 50% of people. In less the autonomic regulation the pulse than 5 beats/minute heart rate was rate was measured at the radial increased in 15%, on 5-12 beats - artery for 1 minute, while sitting, at 7%, heart rate was increased by rest, before emotional stress and more than 12 beats per minute in after it. The creation of a mild 30%. The pulse rate dropped in 30% emotional stress in the form of of students in 5-12 times per minute, assignments of licensing and 20% remained unchanged. examination "KROK-1" for last Conclusions. The studies have semester was a stress factor. found that during mild emotional Results of research. In groups stress there are changes in the with good progress the pulse rose direction of strengthening of from 70 % of students: less than 5 sympathetic influences, to a greater beats per minute in 23%, 5-12 extent among students with high beats/minute - 40% and by more academic performance(70%). This is than 12 beats a minute in 7%. The due to the stronger emotional stress heart rate decreased from 30% of in students who have a responsible students: less than 5 beats per attitude to the educational process. minute in 15%, and 5 to 12 beats per

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Zavgorodniy. A. Karnaukh E., BIOTECHNOLOGICAL INNERVATION AGAINST THE HEPATITIS C Department of Pharmacology and Prescription writing Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Currently, hepatitis stimulates the process of antigen C occupies a significant place in the presentation to immunocompetent structure of morbidity and mortality. cells, has the ability to stimulate the In the world of chronic hepatitis C phagocytic activity of macrophages (CHC) It affects about 3% of the and cytotoxic activity of T-cells and population, or about 180 million "natural killer" involved in antiviral people. immunity. It is used at a dose of 3 Aim. Based on the reviewed million IU 3 times a week during 24- literature to summarize information 48 weeks. Interferons are used in on current antiviral drugs, which are combination with ribavirin. This used for medical treatment of viral therapy is effective in about 75% hepatitis. after a year of treatment. This Matherials and methods. For method has serious side effects: the treatment of hepatitis C using aplastic, hypoplastic anemia, dryness preparations prepared by genetic of the oral mucosa, nausea, changes engineering - recombinant alpha- in TSH levels, thyroid dysfunction, interferons. arthralgia, myalgia, allergic Results. Interferon alfa-2a reactions. A new class of drugs - anti- (Roferon-A), one vial contains 18 virus agents a direct action - million IU of recombinant interferon sofosbuvir. It suppresses the alfa-2a and 0,005 mg of human replication of hepatitis C virus. serum albumin, the minimum Conclusions. Treatment combination therapy Roferon-A with during the first six months is more ribavirin it lasts 6 months. Initial effective than once hepatitis C has dose - 6 million IU 3 times a week for become chronic. Sofosbuvir with 3 months, maintenance dose - 3 ribavirin and interferon appears to million IU 3 times a week for an be around 90% effective in those during 3 months; Interferon alfa-2b with genotype 1, 4, 5, or 6 disease. (Altevir) exhibits a nonspecific Sofosbuvir with just ribavirin antiviral and antiproliferative appears to be 70 to 95% effective in activity, gives the synthesis of viral type 2 and 3 disease but has a higher RNA and viral proteins in the cell and rate of adverse effects.

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J.G. Zhadan, T.M. Sazonova THE STUDY OF THE CRP LEVEL IN BLOOD SERUM IN DIFFERENT TERMS AFTER THE SIMULATED CRYONECROSIS OF MYOCARDIUM

V.N.Karazin Kharkov National University Medical Faculty. Department of Human Anatomy Scientific supervisors: Dr. Panov S.I., Associate Professor of the Department of Human Anatomy; Dr. Sherstuk S.A., Professor, PhD, the Head of the Department of Human Anatomy

The development of 28th day of supervision. Researches myocardial infarction is the reason of were carried out by means of the the occurrence of systemic and local using of the immunoenzimic inflammatory reaction and activation analyzer «Labline–90» and the of an acute-phase protein, like C- commercial test-system of the reactive protein. The ratio between company “Vector Best”. The amount the CRP and cardiovascular diseases of the CRP was measured in mg per a has been researched for the many liter of serum. years. The results are described in Results. The study found the many researches. increasing CRP level in blood serum Purpose of work is to determine the after the simulated cryonecrosis of CRP level in blood serum in different myocardium on 7th day by 70,2 terms after the simulated myocardial percent from the normal amount, on infarction by means of local dosed 14th by 70,4 percent and on 28th day cryotherapy on 7th, 14th and 28th by 70,8 percent from the normal day of supervision. amount. Materials and methods. Conclusion. The research Experiments were carried out on 43 demonstrated increasing CRP level in mongrel male rats. The myocardial blood serum after the simulated infarction model was made surgically cryonecrosis of myocardium on 7th, on rats, using the ether mask 14th and 28th day of supervision anesthesia. Heart cryotherapy was that characterizes CRP as a marker of carried out by means of the nitrogen the inflammatory process after cryotools with an applicator under - myocardial infarction. 196 °С. The CRP level in blood serum was researched on 7th, 14th and

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DENTISTRY

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ISIC-2016 Abstract book Al-Salihi A.I. LONG –TERM RESULTS THE USE OF DIODE LASER 940 μm IN THE DURING PERIODONTAL THERAPY Research advisor: Cherepynska Ju. A., PhD Therapeutic Dentistry Department, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Mechanical remove of planning, gel application CHX 0.5% - biofilm can’t completely remove 5 min. The treatment protocol of 2nd periodontal pathogens, which may group additionally include laser lead to recurrence. Diode laser irrigation of periodontal pockets technology can additionally have a (940 μm, uninitiated light guide Ø photothermal devastating 300 μm, 1W/CW), coagulation of soft effect,coagulating impact on soft tissues of a periodontal pocket and periodontal tissue, reengineering de-epithelization of gingival margin and bio-stimulating effect on the (940 μm, initiated light guide Ø 300 healing process. μm, 2W/CW). The treatment The aim to explore the protocols in the 3rd group were dynamics of the degree of clinical analogous to the 2nd group but attachment loss (CAL), probing excluded antiseptics. All patients pocket depths (PPD) and bleeding were given standard oral care index (BoP) in the complex recommendations. Basing on the treatment of patients with chronic periodontal card data in 6 weeks, 3, 6 generalized moderate periodontitis and 12 months, the treatment while using the diode laser 940 μm. protocol was repeated in the Materials and methods: 30 respective groups. patients aged 35-44 with chronic Results: In 6 weeks, 3, 6 and generalized II degree periodontitis 12 months after treatment positive were divided into three equal groups dynamics was observed in all groups, at random. Local selection criteria: but the values of BoP and CAL/PPD index PI ≥ 25%, BoP ≥ 40%, PPD ≥ in the II and III groups were more 4mm. General selective criteria stable than in the I one, and the excluded: oral antiseptics and dynamics of indices in the II and III antibiotics during last three months, groups were almost similar. pregnancy, any systemic disease Significantly different among affecting the results of clinical themselves (p<0,05 ). studies. The treatment protocol in Conclusions: Results of the 1st group: sub-gingival irrigation clinical studies indicate that the use with H2O2 3%, 0.2% CHX, electro- of diode laser 940 μm during the mechanical removal of dental plaque, complex therapy of patients with sub-gingival scaling and root chronic generalized moderate

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ISIC-2016 Abstract book periodontitis is clinically justified, medications. Further study of long- appropriate and effective additional term results of this treatment will way of treatment allowing to reduce allow comparing the duration of the surgical intervention and remission in these groups.

Baghdadi Moustafa, Nadhim Ahmed, Alkhdo Ali, Almaho Mustafa, Palii O.V. STATISTICAL ANALYSIS OF HYGIENE TOOTHPASTES BY STUDENTS OF FACULTY OF DENTISTRY Research advisors: Ryabokon E.N., Garmash O.V. Department of Therapeutic Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Epidemiological dental faculty of Kharkiv National studies conducted in different Medical University. countries have shown that Results: The results show that periodontal disease is the most among the foreign students surveyed common pathology, which occurs in (32 persons aged 18-25 years), the different groups up to 80% of the most popular is Colgate toothpaste population. WHO data show the (43,75%). Second place on the use progression of periodontal disease in takes Sensodyne pasta in its various countries where the hygienic state of versions. the oral cavity is ignored by It should be emphasized that population or provided not enough. 54.37% of the people use different The aim: One of the trends in toothpastes with bleaching effect. order to strengthen the resistance of Thus, on the first place is Blend-a- hard tissues of teeth and periodontal med 3Dwhite (27,3%), then Closeup tissues is the use of health (18,2%), ROCS Whitening (9,1%), instruments (paste, mouthwash, and others. Pastes for the prevention etc.). Despite the wide range of and treatment of periodontal toothpastes on the market, deseases amounted up to 18,75%. distribution of advertising media and Conclusions: Despite the fact electronic network, the patient alone that among Arab students there are has to make the choice and it is significant percentage of periodontal difficult one. Based on the above, it is diseases, this young people prefer to interesting to study the variety of use whitening toothpastes, rather therapeutic and prophylactic than treatment and prevention one. toothpastes selected by students of Thus they choose aesthetic result, rather than curative.

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ISIC-2016 Abstract book Belyaev P.V. NEW APPROACHES TO COMPREHENSIVE TREATMENT INFLAMMATORY DISEASES OF MAXILLO FACIAL REGION Course of Dental Surgery the Faculty of Postgraduate Education, Vinnitsa National Pirogov’s Memorial Medical University, Vinnitsa, Ukraine.

Actuality: The problem of traditional methods. Evaluating the inflammatory 84axilla-facial region effectiveness of the treatment was diseases treatment is one of the most performed due to clinical, laboratory, serious problems of modern microbiology, cytology and statistical dentistry. We have developed a new research methods. method for the treatment of Results: The results showed inflammatory diseases, based on the that at the main group of patient use of Nanodispersed silica with normalization of clinical and cationic surface active antiseptic, laboratory parameters took place directed antimicrobial agents more quickly than in the comparison transport into inflammatory region group. Cytological picture showed and immunomodulatory therapy. that at the main group inflammation The aim is to confirm the almost completely disappeared at 5th effectiveness of the developed day of observation, refined wounds method for treatment of of necrotic tissues, appeared bright inflammatory 84axilla-facial region red granulation, bacterial wounds diseases. contamination was below a critical Materials and methods: level, which allowed to stitch Comparative assessment of the secondary sutures. While in the effectiveness of the developed comparison group and even at 6th inflammatory diseases treatment day of observation granulation tissue method was conducted in 67 was pale and partially filled the patients with purulent-inflammatory wounds. At tsytohramas were diseases of 84axilla-facial region. determined degenerative modified They were divided in two groups. leukocytes and neutrophils with Patients were representative for incomplete phagocytosis, although pathology, age, sex and co- observed activation of phagocytosis morbidities. All patients underwent and the presence of fibroblasts. disclosure suppurative focus and its Microbial contamination of wounds drainage. In the main group (32 was significantly higher than in main patients) the postoperative group patients. Completing Of the treatment was performed by first wound healing phase in this developed methodology and in the group of patients was only at 7th-8th comparison group (35 patients) – by

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ISIC-2016 Abstract book day, which required a prolongation microorganisms, leaded to the early of 85axilla85ization. appearance of granulation, Conclusions: Treatment of stimulated of reparative 85axilla-facial region inflammatory regeneration processes, and allowed diseases by the developed method to reduce the time patients ensures rapid purification of wound hospitalization. surface from necrotic tissues and

Bogatu Svitlana IS THE ASSOCIATION BETWEEN GASTRIC HELICOBACTER PYLORI INFECTION AND ORAL PATHOLOGY? Research advisor: Prof. Shnaider Stanislav Arkadiovych Odesa National Medical University Department of general dentistry

Introduction. Helicobacter Aim: to review the literature pylori (HP) infection is one of the and to reveal the relationship most prevalence bacterial infection between HP infection and pathology in the world. HP is a gram-negative, of the oral cavity, such as periodontal spiral or curved, microaerofilic disease, recurrent aphthous bacterium, producing the urease. HP stomatitis (RAS) and halitosis. causes the develop of chronic Results. In patients with HP- gastritis (typeB), gastric and positive gastric pathology duodenal ulcer, MALT-lymphoma periodontal disease are more and adenocarcinoma of the stomach. pronounced, and occur more Considered, that the only natural actively, subgingival plaque (in this place of HР existence is the gastric case) is a reservoir of HP. HP- mucosa. Numerous studies of foreign eradication therapy (HPET) scientists have shown the presence conducted alone will not be effective of НР in different biotopes of the oral for the control of gastric reinfection. cavity: in dental plaque, saliva, RAS is the oral inflammatory disease, periodontal pockets and on the characterized by the presence of prosthetic surface. The oral cavity erosions / ulcerations, ulcers with has been suggested as a permanent necrosis, surrounded by an reservoir of НР and the source of erythematous halo lying beneath the self-infection and re-infection in mucosal lining, which relates to a patients after successful eradication keratinized mucosa. Porter et al. in stomach. Currently, HP is regarded reported about positive serology in as an etiological factor of a number RAS, which determined the relative of diseases of the oral cavity. frequency of HP-antibodies IgG with 85

ISIC-2016 Abstract book small aphthous ulceration. Most that halitosis is frequent and curable authors suggest that HPET symptom HP-positive non-ulcer significantly improved the course of dyspepsia, and can be justified the RAS and reduced the number of indication for HPET. The clinical relapses. A lot of researchers have symptoms associated with bad tried to correlate halitosis and HP. breath and periodontal symptoms The first were Tiommy et al., who were significantly manifested in HP- studied patients with halitosis, who positive patients. After the triple was HP-positive. They found that the HPET halitosis disappeared in 90- halitosis had disappeared after 100% of cases. HPET, and highlighted the possible Conclusions. All the above association between halitosis and HP shows the association between infection. Serin et al. assigned triple gastric HP infection and oral HPET duration of 2 weeks in patients pathology. Therefore, oral diseases with halitosis and HP-positive gastric on the background gastric pathology pathology. They reported in patients should be considered as the complex with proven HPET, halitosis was the problem and co-treated by a most successful foregone conclusion gastroenterologist and dentist. symptom. Therefore, they believed

Dotsenko D., Vishnevetskaya A. EARLY DETECTION OF PEMPHIGUS VULGARIS IN THE ORAL CAVITY Research advisor: PhD. Kamina T. Department of Therapeutic Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Pemphigus vulgaris epidermis only after a few months or (common pemphigus) is an years. autoimmune disease, characterized The aim: As a rule, mucous by the blisters in mucous membrane lesions are observed at membranes and skin, turning into different stages of the disease. bursting bright pink erosion. Generally, it rarely happens to see Morbidity for this disease is 0.1-0.5 the not-opened blister because of the per 100000 population in the world. fragility of its membrane People between the ages of 30 to 60 mechanically damaged during food suffer from it. About 2/3 of the cases intake. Round or oval erosions on the begin with the emergence of blisters non-hyperemic mucous are to be in the oral cavity, and involving the found in the mouth cavity. Erosions can be red and moist or “sebaceous”, 86

ISIC-2016 Abstract book the surface of which is covered with mucous membrane epithelium of the fibrinose films. On the periphery of mouth is softly moistened; there are erosions whitish scraps of cystic singular fragile painful erosions at operculum are observed. Its the stage of epithelialization, the pandiculation with forceps can cause diameter 0.5-0.7 mm in the area of the disruption of epithelium beyond occlusion of teeth on the right cheek the erosion (sign of Nikolsky is and side face. At the time of the positive). Operculum of the opened examination of the patient’s general blisters remain on the erosions, state was classified as moderately making a whity-greish plaque, severe. The patient also marked that nevertheless, it can be easily for over 2 years till the final removed with a spatula. The diagnosis accidental trauma of the diagnostics of pemphigus vulgaris mucosa was accompanied by include clinical and laboratory subjective feelings. At the beginning, proofs. Acantholytic cells are the patient didn’t resort to medical changed cells of the spinous layer, help, then during the sanitation that underwent acantholysis and complained about it to the dentist’s, degenerated, that’s why acquired but received only general morphologic and tinctorial recommendations on oral care. The characteristics, distinguishing from diagnosis was made at the stage of over normal cells of that layer. involvement of the skin cover in the Materials and methods: pathological process. During the consultation service Conclusions: Early diagnostics patient A., 28 years old, complained of the disease presupposes more about tender erosions on the whole chances for patient’s further skin cover, obliged restriction of a properly functioning life. It consists body position and movements in timely referral to a doctor, namely because of the massive affect of skin to the dentist, as its primary cover and faint. The pale pink germination begins in the oral cavity.

Kishkan A., Marinko Z., Tishchenko A., Slavich A. EXPERIENCE OF PLANT-BASED GEL IN TREATMENT OF CHRONIC CATARRHAL GINGIVITIS Research advisor: Slavich A. Department of Restorative Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine Actuality: WHO data indicate a relevant in the present days. Local high prevalence of periodontal drug therapy with the use of plant disease among the population. In this medicine has much fewer side effects regard, the choice of medicine used than chemical substances and it to treat them, continues to be takes one of the leading places in the 87

ISIC-2016 Abstract book complex therapeutic measures when condition and other research treating periodontal diseases. methods. The aim of work was to study All examined patients after the effectiveness for clinical professional oral hygiene had gel application of preventive anti- application to the buccal and lingual periodontal plant-based gel in the surfaces of the gums on upper and treatment of chronic catarrhal lower jaws, as well as in the gingival gingivitis (CCG). and periodontal pockets using a Materials and methods: We cannula needles, exhibition – 4-5 conducted a comprehensive min. After the procedure, patients treatment of 24 patients aged 18 – were not recommended to eat for 40 48 years with the CCG. There was – 60 min. The home patients were used plant-based “Abigel” gel (PP trained to apply self-application gum “Latus”, Ukraine). gel for 3-4 minutes, two times a day. “Abigel” is a semisolid gel containing The treatment course lasted 4-6 fir oil, oak bark extract, gelling days. agents, synthetic resin and water. Results: After the treatment The main property of oak bark is there was observed a positive trend astringent action; it also has during the pathological process in hemostatic, antiseptic and anti- the periodontium among all 24 inflammatory characteristic. Fir oil (100%) patients with CCG. Patients has disinfectant, antibacterial, had decreased intensity of antiseptic, anti-inflammatory, pain- inflammation indicators, increased relieving properties. “Abigel” capillary resistance to vacuum, stimulates recovery of gingival improved performance of hygiene tissue. It is rapidly absorbed by oral indices. mucosa. Conclusions: Thus, our results The diagnosis was carried out on the point to the effectiveness of the basis of patients’ complaints, plant-based “Abigel” gel in the anamnesis, clinical status, index complex treatment of chronic assessment of periodontal tissue catarrhal gingivitis. This gel can be recommended for use in practice.

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ISIC-2016 Abstract book Kryvenko L. COMPARATIVE CHARACTERISTIC OF PERIODONTAL AND ORAL HYGIENE STATUS IN CHILDREN WITH ALLERGIC DISEASES Research advisor: Professor Nazaryan R. Pediatric Dentistry, Pediatric Maxillofacial Surgery and Implantology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Allergic diseases with allergic rhinitis and atopic such as bronchial asthma, allergic dermatitis and the control group. rhinitis and atopic dermatitis are a The average age of patients was 11,9 global public health problem. The (± 0,22) years for bronchial asthma prevalence of these diseases is group, 13,1(± 0,26) for allergic increasing worldwide, especially rhinitis, 10,2 (± 0,18) for atopic among children. dermatitis and 15,2 (± 0.23) years The aim to compare for the control group. When periodontal and hygienic status of comparing the level of hygiene oral cavity in children with bronchial between the main groups and the asthma, allergic rhinitis and atopic comparison group, the average score dermatitis. for asthmatics MQHPI was equal to Materials and methods: 96 2,03 (± 0,52), for allergic rhinitis patients with bronchial asthma, 1,87 (± 0,43), for atopic dermatitis allergic rhinitis and atopic 1,94 (± 0,61) compared to 1,29 (± dermatitis, aged 5 to 18 years, were 0,31) in the control group, the examined to identify their hygienic difference in the groups was and periodontal status. The results of statistically significant (p <0.01). In the dental examinations were determining the degree of gingivitis, compared with the control group (30 the difference between the main patients), corresponding by age and group and the comparison group was gender. Hygienic status was also reliable – 1,82 (± 0,41) among determined using a modified index children with asthma, 1,67 (± 0,52) Quigley-Hein (Modified Quigley-Hein in allergic rhinitis group, 1,53 (± Plaque Index, MQHPI), the degree of 0,64) in atopic dermatitis group and gum inflammation – through 0,29 (± 0,43) in the comparison bleeding gums index (Sulcus group. Bleeding Index, SBI, Mühlemann and Conclusions: Children with Son 1971). such allergic pathology as bronchial Results: Showed the worst asthma, allergic rhinitis and atopic hygienic status and degree of gum dermatitis should be referred to the inflammation among children with group of risk associated with asthma when compared to children periodontal diseases (gingivitis).

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ISIC-2016 Abstract book Pavlova K. THE POSSIBILITIES OF PHONOGRAPHIC METHODS OF RESEARCH OF A CONDITION OF OCCLUSION AND EFFICIENCY OF MASTICATORY PROCESS Research advisor: Ph.D. Krivchenko Y. Department of Anatomy, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: The modern world study of the state of the teeth-jaw of dental practice has achieved system. We studied by this method considerable success in providing 29 patients aged from 13 to 17 years, quality patient care. At the same of which 17 patients represented a time, literature data and statistics control group, i.e. patients with indicate a significant number of normal occlusion and 12 patients patients who complain of so-called with various disorders of occlusion facial pain, caused by incomplete and bite (progenic, prognathic, open, recovery of interdental contacts the cross ). 87 measurements of upper and lower jaw, the so-called phonograms, which were able to occlusion, after treatment. Diagnosis assess the efficiency of the chewing of the state of efficiency of the process were performed. A chewing process, which indicates the comparative evaluation of completeness of rehabilitation of masticatory efficiency by the method dental patients has importance. of I. S. Ruby, made the analysis of The aim to study the literature, scientific works, which anatomical structure of the upper helped to create a more simple and and lower jaws, find out the possible affordable method to study the anatomical changes and functional functional state of the teeth-jaw disturbances due to improper system. occlusion, to develop and carry out Conclusions: The main approbation phonographic methods conclusion that we made from the of research of functional state of results of the research, is that our occlusion and masticatory efficiency, phonographic method of assessing evaluate opportunities, information, the process of closing teeth and and the accuracy of the determine the effectiveness of the phonographic methods of the study chewing process allow to diagnose of occlusion and masticatory disorders and evaluate the degree of efficiency of the process for normalization. And, based on the fact assessment of the functional state of that the methods are simple, dentoalveolar system in comparison informative, reasonably accurate, do with traditional diagnostic methods. not require special training and Materials and methods: We conditions for their conduct, they offered scheme of phonographic may find widespread use in dental

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ISIC-2016 Abstract book practice. .

Melynuk V. S., Horzov L. F., Sabov A.V. SOCIAL ASPECTS OF PROVIDING DENTAL CARE IN UZHHOROD CHILDREN Department of Pediatric Dentistry, Uzhgorod National University, Uzhgorod, Ukraine Actuality: The provision of visitors there were more persons free, affordable and quality dental over the age of 36 years is 52.5 %, care need especially to vulnerable from 26 to 35 years of age and segments of the population such as 36.2%. Rarely, the patients with children with disabilities, families in children were people aged 18 to 25 which the parents are themselves years are 11.2%. Private clinics also disabled, orphans. prevailed parents aged 36 years and The aim to study the above is 56% and from 26 to 35 availability and people’s satisfaction years – 42% of 18 to 25 years – 2%. in receiving timely, quality, effective It is obvious that for young parents dental care to children in Uzhgorod. aged 18 to 25 years old, seeking Materials and methods: With dental care in private clinics is not the aim of exploring and comparing available due to a lower level of views of patients with children, their welfare. satisfaction with the organization, The survey results allowed us availability and quality of dental to obtain information about marital services conducted a survey of 156 status and family composition of respondents. Developed a respondents. Found that among questionnaire, which included parents who attend public clinics and questions about gender, age of 46% has a complete family. Full parents; questions that indicated the families with children with social status of the respondents disabilities make up 6%, full large evaluated the level of social families – 9%, full families with protection of families who sought children with disabilities – 2%, medical dental care (the number of single-parent families make up 20%, children in the families of children single-parent families with disabled with disabilities, family members). children – 9%, part of a large family – Results: In state of the dental 3%, incomplete families with clinic turned the vast number of disabled children – 5%. In private female parents of 88.8%, male – clinics the number of complete parents 11.2% and private clinics – families was 44%. Full families with women – parents 86%, while the disabled children – 11%, full families percentage of parents-men was 14%. with many children – 4%, full In public dental clinics among families with disabled children – 0%. 91

ISIC-2016 Abstract book In addition, studying the composition be noted that at public dental clinics of the family, we can highlight the have a higher percentage of visits of socially unprotected group of the the respondents with low income population, which includes families was 18.8%, while private clinics with low-income, single-parent account for only 2% of visits to low- families, large families, and families income citizens. with children with a disability. 2.5% Conclusions: 54% of the of respondents who applied to public families participating in the survey clinics evaluated the material wealth belong to socially vulnerable groups of his family as high, at 78.8% of the population. 42.5% of consider material wealth as the respondents could not afford to use average, and 18.8% are low. Of those paid medical services, as this will respondents who had accessed seriously affect their family budget. private clinics 2% of the assessed Out of 156 respondents, only 23.8% wealth of their family as high, 96% of the children are treated entirely average, 2% of respondents believe free, others have to pay for dental that they have a low affluence. It can treatment.

Slynko Y. INFLUENCE OF LOW PHYSICAL ACTIVITY AT MORPHOFUNCTIONAL STATE IN PERIODONTAL LIGAMENT OF PREGNANT RATS POSTERITY Research advisor: Prof. Rjabokon E. Department of Therapeutic Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine Actuality: In present time are Histological, morphometric, and born and becoming adult children immunohistochemical features of whose mothers had inactive mode of periodontal ligament in three- living during their pregnancy. In this month-old posterity of WAG rats, connection exists the necessity in the whose mothers were having profound studying of an influence of different physical activity during mothers hypokinesia on the gestation had been studied. condition of various organs and Posterity of female rats, which systems in their children, including stayed in the cells of a standard size dentoalveolar system. during gestation, were included in The aim: Purpose is to study the first group (gr.K, n = 27). the microstructural features of Posterity of female rats, who during periodontal ligament in pregnancy stayed in cells with experimental animals, whose reduced area for possible movement, mothers were in hypokinesia were included to the second group condition during their gestation. (gr.GK, n = 25). Materials and methods: Results: Collagen fibers in 92

ISIC-2016 Abstract book periodontal ligament of microslides comparison with gr.K (Rk-gk< 0,05). in gr.K are thin, have sinuous Also it is necessary to note that in disposition that is check with it’s microslides of gr.K are found normal structure. destruction zones in periodontal Immunohistochemical reaction on ligament even to 1/5 tooth root type I collagen gives intensive length. The space between gum and luminescence (0,349±0,012 the tooth filled by granulation tissue, st.un.opt.den). infiltrate by neutrophils, In microslides of posterity gr.GK macrophages and lymphocytes. periodontal ligament is very Above-mentioned situation is typical defective that is shows indirect it’s for dystophyco-inflammatory infirmity in contrast with control diseases in periodontal tissues. group. In extant areas periodontal Conclusions: Thus, in female ligament fibers looks straight, thin posterity that during their pregnancy and rarely situated. was in hypokinesia condition , Immunohistochemical research on periodont has depressed morpho- type I collagen is an evidence of it’s functional activity, that can be one of smaller content in periodontal fibers the starting device in periodontal (0,264±0,010 st.un.opt.den) in tissues disease evolution.

Steblianko A., Hudik A. EXPERIENCE OF PHYTOPREPARATIONS FOR TREATMENT OFACUTE ODONTOGENIC PERIOSTITIS Research advisor: Prof. Grigorov S. Department of Maxillofacial and Oral Surgery, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: The urgent matter treatment of acute odontogenic of the modern dental practice is to periostitis (AOP). improve the efficiency when treating Materials and methods: The the inflammatory diseases of oral “Tymsal” active ingredient is thyme cavity (IDOC). Medical drugs of plant liquid extract with essential oil origin are mainly used in IDOC which includes antibacterial complex treatment because they do properties of thymol and sage not include chemically synthesized tincture. To investigate the agents with a number of side effects. antibacterial activity (AA) by the The aim was the clinical – “pits” method of solid “Tymsal” laboratory study of preparation diluted 1: 2, 1: 4, 1: 8 phytopreparation efficiency in the there were used clinical and test form of spray – “Tymsal” (“Herbapol strains Pseudomonas aeruginosa, Krakow S.A.” company) during the Proteus penneri, Micrococcus luteus, 93

ISIC-2016 Abstract book Escherichia coli ATCC 25922, Results: The results Bacillus cereus ATCC 10702, Bacillus demonstrated that the drug “Tymsal” subtilis ATCC 6633, Staphylococcus diluted 1: 2 and 1: 4 showed a epidermidis 209, Staphylococcus bactericidal action to all the studied aureus ATCC 25923, Klebsiella cultures, at a dilution of 1: 8 to some oxytoca, Streptococcus agalactiae of them the bactericidal activity was and Candida albicans, which are reduced. representatives of gram-positive and It is clinically found that even 2 days gram-negative microorganisms. after the surgery and use of “Tymsal” We performed the examination, the patients had no pain and reduced treatment and monitoring of the swelling of tissues area in tooth dynamics among 22 patients aged extraction wells. We also marked the from 18 to 45 years who were beginning of the formation of hospitalized for AOP to the granulation tissue in all (100%) maxillofacial department of the patients of group I, 86% - group II, Regional Clinical Hospital in Kharkiv. 83% - group III. On the 4th day there The patients were divided into three was an active formation of groups: group I patients (9 people) granulation process in the wells of used “Tymsal” in a dilution of 1: 5, extracted teeth in all groups of the group II patients (7 people) – patients (100%). On the 6th day all 1:10, and group III (6 people) – 1:20. the parameters of studied traits were Patients were treated according to 100% among all patients. AOP therapy protocol. Immediately Conclusions: Thus, the AOP after the surgery all patients had the treatment with the drug “Tymsal” in tooth extraction hole filled with swab selected dilutions was rational in all containing preparation of the cases. corresponding dilutions.

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ISIC-2016 Abstract book Volchenko N. PERIODONTAL TISSUE CONDITION IN 8-YEAR OLD SCHOOLCHILDREN WITH DIFFERENT EDUCATION LOAD Research advisor: Ass.prof. Volchenko N. Department of Dentistry, Department of Pediatric Dentistry, Pediatric Oral Surgery and Implantology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Children’s health group ( = 1.76 , p < 0.05). In 60% condition is the condition of health of children of the first group and in 43.3 the nation. In view of the above the % children had a second index is doctors have been working hard to defined, quantitative values are the determine the factors which have an scores from 0.1 to 1.0, which means adverse impact on children’s health. that these children found the risk of The aim was is to investigate disease periodontal a greater extent the features of periodontal tissue in the first group ( = 3.65 , p < 0.01). condition in 8-year old The presence of mild inflammation schoolchildren in terms of education was detected in 7.5% children of the load character. first and 3.3% children of the second Matherials and methods: The group ( = 0.78 , p> 0.05), the research involved 25 children at the quantitative value of more than 2.1 age of 8 –years, 13 of them are points in both groups of enrolled in board education program schoolchildren have been identified, and 12 children are enrolled in means inflammation of periodontal general education program. The tissue of moderate and severe were authors employed index assessment found. of periodontal tissue condition by Conclusions: So, as a result CPI. the authors obtained data suggesting Results: In 32.5 % and the that the majority of schoolchildren, pupils are enrolled in board enrolled in board education program education program 53.3 % children were found to have more signs of are enrolled in general education periodontal tissue inflammation in program of inflammation could not comparison to the children enrolled be detected, especially in the second in general education program.

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ISIC-2016 Abstract book Volkova O. BIOCHEMICAL INDICATORS OF ORAL FLUID OF PATIENTS WITH CARIES AT ACTION OF LECITHIN-CALCIUM COMPLEX Research advisor: professor Ryabocon Ye. Department of Therapeutic Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Integral part of human also significantly returned to normal health is dental health, which is after treatment, “Lecithin-2” (OPA in defined as the state of organs and the control -3,00 ± 0,21, to tissues of oral cavity. medication – 4,05 ± 0,39 nkat / L, p The aim of this study was to <0.05, after 1 month – 2,91 ± 0,29 examine the influence of complex nkat / L, p <0.05). In patients with preparation “Lecithin-2”, lecithin on caries significantly reduced in oral which contains calcium citrate, and fluid concentrations of calcium, as a source of phosphorus which after treatment returned to biochemical indicators of oral fluid of normal, indicating that the multiple dental caries. restoration of remineralizing the Materials and methods: Basic function of saliva (calcium in the groop is 52 patients diagnosed with control -0,92 ± 0,04 mmol / l, before multiple dental caries, which is set the drug – 0,68 ± 0.04 mmol / l, p on the basis of clinical examination. <0.001, after 1 month – 0,88 ± 0,03 Patient’s main groups except the mmol / l, p1 <0.01). More than 2-fold basic therapy the first day of the reduced activity of one of the survey were receiving the drug antioxidant enzymes catalase, and “Lecithin-2” manufactured for thirty after a month of taking the course days, three times a day for half an “Lecithin-2”, this rate was almost hour before meals and one tablet to back to normal (catalase, in control – complete resolve in the oral cavity. 0,305 ± 0,033 mAbs / l, before the Patients in the first day of the survey, drug – 0,14 ± 0.01 mAbs / l, p <0.001, and then a month later to collect after 1 month – 0,27 ± 0,053 mAbs / unstimulated saliva. In the l, p1 <0.05). supernatant was determined the Conclusions: As a result of our concentration MDA, total proteolytic studies found that patients with activity OPA, the activity of catalase, multiple dental caries observed urease and lysozyme, as well as the phenomenon of disbioz of the oral concentration of calcium. cavity for signs of inflammation, Results: As shown by studies of reduction of the protective two inflammatory markers (MDA, antioxidant system and decrease the and UPA) UPA only significantly concentration of calcium in oral fluid. increased in patients with caries and Admission during the month

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ISIC-2016 Abstract book lecithin-calcium complex completely antioxidant-prooxidant system and eliminated the phenomenon of the concentration of calcium in oral dysbiosis and inflammation, fluid. increased to normal levels of

Voloshan O. TREATMENTS FEATURES OF PATIENTS WITH ODONTOGENIC MAXILLARY SINUSITIS OF FUNGAL ORIGIN Research Advisor: PhD., Associated Professor Demyanyk D. Department of Dental and Maxillofacial Surgery, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: The choice of tactic of odontogenous maxillary sinusitis treatment and diagnostic difficulties with the prevalence of the fungus ofpatients with maxillary flora. odontogenic sinusitis are still the The aim 1)to develop common relevant issue inmaxillofacial surgery principles in the diagnosis and ( Teemofev A.A. (2011) , Zaprudena tactics of the treatment process and M.V. (1984), Neupokoev N.N. (1996), rehabilitation period of patients with Morokhoiv V.I (2009). The difficulty odontogenic maxillary sinusitis with in diagnosis , uncontrolled and a prevalence of fungal flora, 2) to inadequate designation of antibiotic , study the most common mistakes in failure in conservative treatment of diagnosis and tactics of the odontogenic sinusitis , creates treatment of patients with conditions for the growth of odontogenic maxillary sinusitis with microorganism ,representing the predominance of fungus flora, 3) Saprophytic flora , increasing to develop the algorithm level of virulence of opportunistic bacteria . surgical intervention in identifying Recently in literature there have odontogenic maxillary sinusitis with been researches that discuss the a prevalence of fungal flora. possibility of developing chronic Materials and methods: We sinusitis on the background of fungal have observed 87 patients with sinus lesions caused by genus odontogenic sinusitis were treated in Aspergillus .Such researches are the dental department in Kharkov rare; therefore survey of literature regional hospital for the period that carried out by us showed the 2013-2016, went through clinical, expediency of further study of laboratory and radiological clinical variety and difficulties of examinations (including a panoramic differential diagnostics during the radiography and cone tomography to treatment of patients with establish the causes of odontogenic ). 97

ISIC-2016 Abstract book At the time of treatment in reconstruction of defects and plastic department, 70% of patients closure of tissue. complained of unilateral nasal Results: The results analysis of congestion, pain in the causative statistical data showed that for a tooth, swelling and hyperemia of the specified period of time in dental gums, discharge from the nasal department 87 patients were treated passage. All patients underwent a , including 10 patients with complex treatment of odontogenic odontogenic sinusitis with a maxillary sinusitis, according to the prevalence of fungal flora. quality standards of the Ministry of Conclusions of postoperative Health of Ukraine in dental material showed that what revealed department. We conducted a radical as «foreign matters» appeared to be cysto-sinusotomy (60) and cysto- Aspergillus niger which stimulated naso-sinustomy (27) (depending on by the presence of filling material in the clinical picture) with bone maxillary sinus.

Yakovleva D. U. MAXILLO-FACIAL SCHWANNOMAS: CLINIC, DIAGNOSTIC AND TREATMENT Research advisor: Сandidate of Medical Sciences Rak A. V. Department of Oral and Maxillofacial Surgery, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Schwannoma is a complained of a painless mass that benign tumor that originates from had been enlarging slowly in the the Schwann cells of the peripheral right parotid gland for the last two nerves. Approximately 25-45% years. The patient didn’t have any schwannomas are seen in the head lymphadenopathy in the and neck region and found rarely in supraclavicular, anterior and the oral cavity, about 1%, affecting posterior region of the neck. the tongue, the buccal mucosa, the Laboratory research included palate, the base of the mouth. ultrasonography and histopathologic The aim to study the features examination. Slides were stained of clinic, diagnosis and treatment of with hematoxylin and eosin, maxillofacial schwannomas. pikrofuksin by Van Gieson, the CHIC- Materials and methods: The reaction was conducted. analysis of literary sources and one Results: Ultrasonography clinical case was performed. Patient showed a hypoechoic mass in size, B applied to the clinic of surgical with irregular shape, clear boundary, dentistry and maxillofacial surgery without calcification. The KhNMU for making a diagnosis. He histopathologic analysis revealed the

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ISIC-2016 Abstract book majority of Antoni B pattern for the the intraparotid facial nerve main whole specimen. This variant is less trunk. In present case the superficial cellular and less organized, parotidectomy with the following representing degenerated Antoni A enucleation of the neoformation was areas. It is composed of hypocellular preferred. Other techniques, such as myxoid matrix punctuated by partial resection, should be avoided microcysties, inflammatory cells and because of the possibility of cause delicate collagen fibers. The tumor neural damages. vessels are sharply thickened due to Conclusions: The fibrosis and hyalinosis. The volume preoperative diagnosis of of operative intervention depends on schwannoma is always difficult. That several factors, like extent and is why, for the facial tumor, surgeons biological behavior of the tumor, often have to convert intraoperative preoperative facial nerve function intervention. Additional methods of according to the House-Brackmann research play a crucial role in the grade, and the location in relation to final diagnosis.

Yarovenko L. SOCIOLOGICAL SURVEU OF THE STUDENTS WITH THE PROGNATHIC OCCLUSION OF THE CITY LVIV Research advisor: Bezvushko E., Dr. of Med. Sciences

Children stomatology department, Lviv National Medical university after Danylo Halytskyy, Lviv, Ukraine

Relevance: According to the Materials and Methods: For literature, teeth anomalies take the conducting our research 750 pupils third place of all dental diseases in aged 9 to 17 of secondary schools the world today. The prevalence of №65, 67, gymnasiums "Hrono", the prognathic occlusion (PO) ranges "Oriyana", "Sykhivska" in Lviv and from 16,2% to 23,93%. patients of Medical Dentistry of Lviv Objectives: To determine the National Medical center after Danylo degree of emotional state of school Halytskyy were questioned. All children and adolescents with and respondents were divided into without the dental-jaw anomalies groups – the main group - patients and with the PO according to a with PO (150 - students) and the questionnaire survey. Conduct a control one (600 students). The comparative description. surveyed students were also divided into groups regarding to the age: the 99

ISIC-2016 Abstract book first group - 9-10 years old, the To the question "How do you second group - 12-13 years old and assess the state of your teeth and the third one- 16-17 years old. gums?" the majority of pupils in the The results: Thus, when control group (45,3-63,3%) rated it exploring the question "How as a good one, but only one third of important is your health to you?"we the pupils from the main group was marked the highest possible interest. satisfied with their teeth and gums The children 9-10y. (34%) and 12- 24-44%. 13y. (40%) with the PO assessed the Therefore, to the question "Are state of their health the most you satisfied with the appearance of carefully and the children in the your teeth?" the main group of pupils control group:9-10y. (23,3-53,3%) of all ages responded not happy with and 28-50,6% of children 12-13y.in 38-58% respectively, whereas in the accordance. control group satisfied with most of For the question "How much are the respondents, satisfied with the you satisfied with your health?" the appearance of their teeth is 56,6- main group of the respondents of all 85,3%. ages mostly said they were satisfied Although interesting is the fact with their health (50-64%). While that it does not affect the desire to the control group of the respondents smile. Thus, the pupils of both more carefully evaluate their health groups smile free: 82,6-91,3% and with the time: aged 9-10y. - more 58-84% respectively. than half (58,6%) - quite satisfied Conclusion: The analysis of the with their health, aged 12-13y. - 50% results of the questionnaire survey and aged 16-17y. only a third is shows a direct relationship between satisfied (36,6%). Hence, the the dental status and the emotional importance of health for pupils, who state of the patient, which certainly were questionned is a priority issue affects the quality of life. in both groups and doesn’t depend on the age.

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ISIC-2016 Abstract book Yeliseyeva O. ORAL CAVITY IMMUNITY CHARACTERISTICS IN THE PATIENTS ORAL LICHEN PLANUS Research Advisor: DM. Sokolova I. Department of Dentistry, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: A firm tendency of rinser “Lizomukoid”, toothpaste frequent combination of chronicle “Lakalut active”, pills “Lisobakt”, generalized periodontitis (CGP) and patients of subgroup 3b also had oral lichen planus (OLP) has been lysozyme containing films observed recently and known application). Systemic treatment of treatment measures often give OLP was also conducted (after a insufficient therapeutic effect. specialists’ advice). The aim: The object of the Results: The reduction of the research is to study the state of the lysozyme and beta-lysine level, C3 local oral cavity immunity of the fragment and also sIgA level in the patients with generalized oral cavity liquid has been observed. periodontitis together with oral After the treatment in subgroups 2b lichen planus. and 3b normalization of the above Materials and methods: 52 mentioned characteristics level in patients who were divided into 3 the oral cavity liquid has been groups took part in the research. observed during all the treatment Group 1 included patients with intact period. In groups 2a and 3a there periodontium. Group 2 included weren’t any significant changes of patients with CGP together with OLP these characteristics (p>0,05). and without injury of the oral cavity Conclusions: Successful mucous membrane (OCMM). Group 3 treatment of the patients with CGP included patients with CGP together together with OLP according to the with OLP and OCMM injury. Groups 2 worked out scheme is accompanied and 3 were subdivided into 2a and by restoration of the local non- 3a (those patients had standard specific immunity characteristics of treatment: rinser “Perio-AID” 0.12%, the oral cavity such as lysozyme and toothpaste “Lacalut active”, and beta-lysine activity, C3 fragment patients of subgroup 3a also had sea- complement concentration, and also buckthorn oil application on lesion sIgA level normalization just after focuses) and 2b and 3b (those the end of the course of treatment patients had the worked out therapy: and in 3 months after the therapy.

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ISIC-2016 Abstract book Zaarour A., Rabih S. ESTIMATION OF ARTICULATION OF ORGANS OF HUMAN SPEECH SYSTEM IN A DIRECTION OF EXTENDS THE POSSIBILITY OF INDIVIDUAL CORRECTION OF TREATMENT AND PREVENTIVE MEASURES IN PEDIATRIC DENTISTRY Research advisor: Kuzina V., Assoc. Prof.; Khmiz T., Assoc. Prof. Department of Pediatric Dentistry, Pediatric Maxillofacial Surgery and Implantology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Prevention of dentofacial facial features and intraoral for the deformities – an important link in purpose of recording the presence of pediatric dentistry. Timely and the bite pathology and its kind were correct prevention allows to avoid or conducted. reduce the time of wearing of Results: The 25 persons were complex orthodontic appliances, and selected, according to the results of promotes the self-elimination of the survey. They pointed to the use certain anomalies during childhood. of only one language within the first The aim to study the 10-15 years of life that corresponds proportion of persons in carriers of to the period of active formation and foreign languages with different growth of the maxillofacial region. articulation characteristic. Everyone had bite pathology, with Materials and methods: The typical facial features and a tendency questioning of foreign students, to uniformity. natives of the Asian region, in order Conclusions: The obtained data to establish the type, duration and should be taken into account during frequency of use of language in the inspection of patients, whose childhood was conducted. Surveyed mother tongue or the language in were asked to tell about themselves which the patient says most of his in their native language. The life, is characterized by specific articulation movements of the articulation, and differ from the tongue and lips were recorded using Ukrainian or Russian. It extends the a video at the same time. Both, possibility of individual correction of extraoral examination of the treatment and preventive measures maxillofacial region with an in pediatric dentistry. emphasis on the presence of the

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ISIC-2016 Abstract book Мikulinska – Rudich Y.N., Mys V.O. EXPIRIENCE IN THE USE OF FLOWABLE COMPOSITES FILTEK BULK FILL AND SDR FOR SEALING OF UPPER MOLARS Research advisor: M.D., Doctor of Medical Sciences, Professor Nazaryn R.S. Department of Pediatric Dentistry, Pediatric Maxillofacial Surgery and Implantology Department, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: When working with smoothly without delays, saving the kids dentist is constantly faced reduced when filling the anatomical with a number of problems that are shape of the tooth, which indirectly associated with psychological and testifies reducing the polymerization emotional state of the child’s specific shrinkage stress and the minimum behavior, inherent in childhood. basic materials for replacement of The aim to compare the dentin. However, in the first group, efficacy of flowable composite which was conducted 3M ESPE Filtek materials for filling cavities 1 class in ™ Bulk Fill Treatment of material the maxillary molars in children 12 decay was observed color mismatch to 14 years. seal / enamel in 13 of 21 the treated Materials and methods: In tooth. children receiving treatment was Conclusions: Based on the made the upper permanent molars results of clinical studies we (42) for chronic middle caries conducted among children 12 to 14 company materials 3M ESPE Filtek™ years who underwent dental filling Bulk Fill and Dentsplay SDR. Parents flowable composite material were informed about the Dentsplay company SDR and composition and the instructions for flowable composite material Filtek ™ use of materials. Bulk Fill 3M ESPE company may be Results: One month after concluded that a satisfactory sealing as a result of an objective adaptation of the materials to the examination of both the first and cavity walls, convenience and ease of second groups studied was use, large depth polymerization that determined good marginal seal seals eliminates the need for making during the probe along the border of layered composite material in the the tooth \ enamel probe slid cavity.

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INFECTIOUS DISEASES

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ISIC-2016 Abstract book Adeyemi A.A., Bondarenko A.V. DIAGNOSTIC APPROACHES IN TICK-BORNE DISEASES Research advisor: Bondarenko A.V., Doctor of Medical Sciences, Professor Department of Infectious Diseases, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Aetiological diagnosis of positive within 2-4 weeks after the tick-borne diseases is often difficult onset. In Anaplasmosis and and interpretation of laboratory data Ehrlichiosis IFA and PCR should be is very important in order to used within 7-10 days after the onset establish the diagnosis. Since many of symptoms and should be repeated patients rarely have the tick in hand, in 2-4 weeks later to reduce the risk a definitive diagnosis thus requires of false negative. In Borreliosis, more specialized methods. patients with symptoms greater than The aim. To help clinicians in 1 month, testing for only IgG should diagnosing infections transmitted by be done, as IgM alone is insufficient tick bites and to provide guideline for the diagnosis. If the result is based on the results of our positive or equivocal it is followed by collaboration with Laboratory of a Western Blot for confirmation. In New and Little Explored Infections Bartonellosis, IFA for both IgM and (Mechnikov Institute of Microbiology IgG antibodies must be used. and Immunology). However, cross reactions may occur Materials and methods. with antibodies to Coxiella, Haemolymph smear, peripheral Chlamydia, and Rickettsia. Western blood smear, immunological tests for Blot tests appear to have greater antigens and antibodies – indirect specificity. Bartonella organisms can immunofluorescent assay (IFA), sometimes be visualized by molecular genetic analysis – immunohistochemicall staining. The polymerase chain reaction (PCR). DNA of various Bartonella species Results. Our investigations, can also be amplified by PCR in showed that, if in some rare cases, blood, spinal fluid and tissue. the patient is lucky to have the tick, it Conclusion. The various would be possible to perform a methods for diagnosing tick borne haemolymph smear, make a diseases have varying sensitivities potential diagnosis, and start proper and specificities, especially when the prophylaxis. time of sample collection is In Babesiosis the gold standard is a considered. The most important thick and thin blood smear to detect diagnostic tests have been described small “Maltese cross” inclusion taking into consideration factors like bodies in RBC’s. PCR and IFA, are the seroconversion time,

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ISIC-2016 Abstract book immunocompromised status of some of these diseases, thus a lot of patients and number of tick borne importance falls on the diagnostic parasites in the organism. It is often tests. difficult to differentiate between

Аntsyferova N., Solmennyk A., Bondar А., Sokhan A., Penkov D, Perelomov V. MODERN UNDERSTANDING OF THE CLINICAL PICTURE THE OF CHRONIC HCV-INFECTION Kharkiv National Medical University (Department of Infectious diseases), Kharkiv, Ukraine

Modern concepts of clinical consultations of interfacing manifestations of chronic HCV- specialists. infection are not limited to liver The results. First became lesion. Many scientists being aware of HCV infection more than discussed the role of the virus in the 6o% patients at the stage of chronic development of a wide spectrum of process. Almost a quarter (24.75%) pathologies: hematological and patients suffered from arthritis, dermatological diseases, diabetes, 2.44% - allergic dermatitis, 1.45% - kidney disease, etc. According to hypochromic anemia, 0.48% - various studies, their frequency has psoriasis for several years before significant differences in different diagnosis. Repeated treatment of countries from 38 to 74%. these conditions in a specialized The aim of the study – to hospital does not have a positive determine the incidence of effect. Analysis of the clinical data of extrahepatic symptoms in the patients in an infectious hospital clinical picture of chronic HCV revealed the prevalence of infection at this stage. gepatomegalia (100%), asteno- Object and methods. The study vegetative (75.24%) and dyspeptic involved of 206 patients with chronic (69.9%) syndromes. Extrahepatic hepatitis C. Along with the manifestations (arthralgia, allergic confirmation of the etiologic dermatitis, anemia, psoriasis) diagnosis the program of general 29.12% were observed in patients. clinical examination included Against the background of combined assessment of complaints and antiviral therapy had complete or anamnestic data, physical partial regression the studied examination, study of the functional symptoms. state of the liver, as well as The conclusion. At the present

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ISIC-2016 Abstract book stage of chronic infection is weight of extrahepatic pathology in characterized by a low specific the the general structure of the disease.

Augusto Maurelio Vicente ZIKA VIRUS, DENGUE AND CHIKUNGUNYA IN BRAZIL: SYMPTOMS, DIAGNOSIS Research advisor: Kovalenko Natalia, asst. prof. Department of Microbiology, Virology, and Immunology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Dengue, and microcephaly was confirmed. chikungunya fever and Zika viruses The severe pain in all joints are three diseases that increase in especially on fingers, wrists and on number of cases and severity and the palms of the hands, ankles and that has the same transmitter: Aedes feet are the main clinical symptoms aegypti. of chikungunya. The aim. One of the main . To establish whether the challenges of health agencies in patient is with Zika, dengue or obtaining reliable data on the cases chikungunya, in addition to of the disease has been the difficulty analyzing the symptoms, the doctor of diagnosis, since the symptoms are may order tests to confirm the very similar and can often lead to diagnosis. Dengue confirmation can confusion with other viruses. be made through serological tests Results. The four dengue ELISA, RT-PCR, or the virus isolation serotypes cause the same clinical in cell culture. It is also antigenic manifestation, that may include: high detection technique NS1 fever with severe headaches, severe (nonstructural glycoprotein 1), bone and muscle pain; fatigue, simpler and cheaper than PCR, reddish spots, diarrhea, vomiting, results in 48 hours (useful for cough, and nasal congestion, but can samples up to the tenth day of progress to diffuse inflammation of disease). In the case of chikungunya, blood vessels and thrombocytopenia. it is also possible to test for serology Symptoms of Zika virus manifest in a in search of the antibody, but Zika mild way. In the first 24 hours the has no test available for serology. rash appears and cause severe Private laboratories are seeking itching, fever is lower, conjunctival genetic material testing (PCR) for hyperemia, muscle pain, headache Zika and chikungunya. However, and back pain, sore throat, coughing, these tests can only be applied until swelling in the body and vomiting. A the fifth day after the onset of relationship between the Zika virus symptoms to the Zika virus and until 107

ISIC-2016 Abstract book the tenth day to chikungunya, since indicates the presence of antibodies after that the virus is no longer on in the blood. Two methods for then organism is not detected by the serology test to detect Zika virus genetic material test (PCR). A new have already developed: the technology, NAT Kit will enable immunofluorescence assay and diagnosis via the identification of the ELISA. The immunofluorescence test genetic material, simultaneously the is able to detect the most common three diseases: chikungunya, dengue flavivirus and arboviruses: the four fever and Zika virus. Currently, the serotypes of chikungunya, dengue diagnosis of Zika virus is carried out and Zika. by RT-PCR in real time, which Conclusions. Thus, laboratory identifies the presence of genetic methods when applied well known material of the virus in the sample. are important to support the work of For chikungunya, the test involves a the physician and should be technique called considered seriously in order to immunochromatography, which avoid errors in treatment.

Dudnik A.Y., Mohylenets O.I. CASE OF PLASMODIUM OVALE MALARIA WITH LONG INCUBATION PERIOD Research advisor - Doctor of medical science Kozko V.M. Department of infectious diseases, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Early and accurate Results. Patient M., 22 years, diagnosis of malaria is essential for was admitted to the KRCHID on the effective disease management and 5th day of disease with complaints of malaria surveillance. High-quality fever up to 38°C, weakness and malaria diagnosis is important in all headache. It was known from settings as misdiagnosis can result in anamnesis that 5 days ago in the significant morbidity and mortality evening he felt chills, but did not (WHO). measure body temperature. He took The aim to optimize the paracetamolum, after that patient diagnostics of malaria in nonendemic noticed a marked sweating and countries for this disease. condition got better. During the Materials and methods: following days he felt satisfactory. On analysis of the patient's case history, the 3rd and the 5th days of illness who was hospitalized to the Kharkiv chills, rise in temperature up to 38,5- Regional Clinical Hospital of 39ºC with following sweating was Infectious Diseases (KRCHID), was observed. From the epidemiological conducted. anamnesis: patient came to Ukraine 108

ISIC-2016 Abstract book from Cameroon (Africa) about a year caused by Pl. ovale, of moderate ago; lives in apartment; denies any severity. The difficulty of diagnostics contact with infectious patients. have resulted from the fact, that From the anamnesis of life it was patient was in an endemic area about known that in Cameroon he had 1 year ago (the incubation period in malaria many times (the last one – most cases of malaria varies from 7 1,5 years ago; he didn’t know neither to 30 days) that had led to reduced species that caused the disease nor clinical suspicion. In case of Pl. vivax treatment he was done). On and Pl. ovale malaria there is examination: general condition of possibility of late relapces and in moderate severity, body rare cases – of long incubation temperature is 38,5°C. The skin is of period (if patient mainly was normal color, without rash. The infected by dormant generation of sclera are subicteric. The mucosa of parasites). the oropharynx is slightly hyperemic. Conclusions. 1. There must be Other organs and systems – without epidemiological and clinical pathology. The preliminary suspicion for malaria by doctors due diagnosis: acute respiratory to growing migration of people and infection? Viral hepatitis? In the international travelling to African blood test – normocytosis (leu – and Asian countries. 2. Considering 4,8×109/l), monocytosis – 15%. In the possibility of primary Pl. ovale liver function test – moderate latency and long incubation period cytolytic syndrome (ALT – 2,44 (about 1 year) of disease, tests for mmol/l). Parasitoscopy: Pl. ovale malaria should be done for all was revealed; parasitemia level – feverish patients who had been in 5220/µl. Final diagnosis: Malaria, malaria-endemic regions.

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ISIC-2016 Abstract book Elkosh Mohamed Moneir STUDY OF ANTIBACTERIAL ACTIVITY OF COMBINATIONS OF TEA TREE ESSENTIAL OIL WITH ANTIBIOTICS AGAINST OPPORTUNISTIC MICROORGANISMS IN VITRO Department of microbiology, virology and immunology Kharkiv National Medical University, Kharkiv, Ukraine 25922 and Klebsiella pneumoniae Actuality. Due to absence of a АТСС 5505. proper antibiotic policy or non- Materials and methods: adherence to it firmly, common Antibacterial activity of the tea tree strains of bacteria develop new essential oil and antibiotics was mechanisms of resistance to widely studed by disc diffusion test used antimicrobial agents which are according to recommendations of the used for many years. These strains International Committee of Clinical are still increasing in number by the Laboratory Standards (NCCLS, time. The resistance has been 2002). observed in both Gram-positive and Results: The tea tree essential Gram-negative bacteria isolated from oil was dissolved in ethanol and specimens of patients with introduced into melted and cooled community-acquired and hospital- meat pepton agar at a concentration acquired (nosocomial) infections. of 70 mcg/ml or 0,007 wоlume %. A new revolution in the field of Suspension of microorganisms combating antibiotic resistance is the (microbial load 2•109 CFU/ml) was development of new added on the surface of cooled agar pharmacological regimens by using then standard paper discs with combination therapy of conventional antibiotics were placed. Inoculated antibiotics with essential oils as sort Petri dishes were incubated in an of phytopharmaceuticals. This incubator at 370 C for 24 hours. combination therapy exhibits Record of the results was carried out efficacy even with plasmid-conferred by the diameter of the zones of multidrug resistant bacteria. growth inhibition around the discs. The aim of our research was Synergistic effects of the tea to investigate synergistic outcome tree essential oil were demonstrated between the tea tree essential oil in combination with doxycycline, (Melaleuca alternifolia) and ceftriaxon, cefoperason and antibiotics against facultative ciprofloxacin against both Gram- anaerobic bacteria such as standard positive and Gram-negative bacteria. strains Staphylococcus aureus ATCC Besides that the tea tree essential oil 25923, Staphylococcus epidermidis enhanced the azithromycin, ATCC 14990, Escherichia coli ATCC cefuroxim and clindamycin activity against S. aureus. Doxycyclin and

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ISIC-2016 Abstract book ofloxacin were more effective in effective dose of antibiotics in the combination with the tea tree treatment of infections that reduces essential oil against K. pneumoniae. the adverse effects of antibiotics. For Essential oil also potentiates the continuation of these promising effect of cefotaxime and ofloxacin investigations we need more studies against E.coli. about molecular basis of synergistic Conclusions: Synergistic effect interactions to understand its of the tea tree essential oil with mechanism of action more and more. antibiotics decreases the minimum

Fatianova F., Vinokurova O. THE DYNAMICS OF INDEXES OF LIPID METABOLISM FOR THE TREATMENT PATIENTS WITH ACUTE HEPATITIS B Research Advisor: Doctor of Medical Sciences, Professor Kozko V.N. Department of Infectious Diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality. According to WHO purpose of establishing the state of data about 2 billion people in the lipid metabolism among patients world are infected with hepatitis B. with hepatitis B we determined the The relevance of HBV is determined content of non-esterified fatty acid, by the fact that currently there are prostaglandins in the serum with no specific highly effective methods gaschromatography method, and the of treatment. Nowadays the study of level of total lipids, cholesterol, β- lipid metabolism during viral liver lipoprotein, diseases is of considerable interest. triglycerides(conventional methods). The Aim of work was the Results. We studied indicators study of the main indicators of lipid of lipid metabolism with regard to metabolism in the serum of patients therapy (defined by its content in with acute hepatitis B during blood serum before and after different methods of treatment. treatment). 1 group consisted of 42 Matherials and methods. We patients with acute hepatitis B who examined 140 patients with acute received basic therapy. Group 2 viral hepatitis B of the age from 16 to consisted of 58 patients with acute 62 years old. The diagnosis of acute hepatitis b, for which in complex hepatitis B was verified using the therapy Erbisol was used. It is methods of enzyme-linked revealed that in the group of patients immunosorbent analysis and where the medicine "Erbisol" was polymerase chain reaction. For the used in comparison to the group of 111

ISIC-2016 Abstract book patients who received basic therapy, three representative groups there was faster leveling of icteric (P>0.05): headache, insomnia, dry syndrome, headache, the duration of mouth, nausea, vomiting, pain and the febrile period was much less, and heaviness in the right there were less pain (epigastric). It is hypochondrium, aholic stool, revealed that (in comparison with constipation, diarrhea. their content before treatment) the Conclusions. Using Erbisol content of biochemical parameters contributes to more rapid decrease fell faster to control values under the of the content of β-lipoprotein, influence of Erbisol – AlAt - 87.9%, triglycerides, prostaglandin F2, bilirubin - at 78.7% (under the action prostaglandin E1, prostacyclin, of Galstena – by 83.6% and 65.4% thromboxane B2, and Using Galstena respectively and the basic treatment contributes to more rapid decrease – of 66.1% and 66.2% respectively). of total lipids, total cholesterol, The duration of subsequent clinical prostaglandin F1, normalization of manifestations of disease did not the level of most fatty acids. differ significantly for patients of all

Ghosh Somdipa CLINICAL PRESENTATION OF TB AMONG PATIENTS WHO HAVE RISK FACTORS OF TB Research advisor: Choporova Aleksandra PhD Kharkiv National Medical University Department of Phthisiology and Pulmonology

Actuality: There are estimated cigarettes a day increases the risk of 8-10 million new cases of TB each TB by 2 or 4 times.Smokers doubles year worldwide.It remains a global the risk that people who have been emergency and continues to kill 1.4 successfully treated for TB will million people every year.CO- develop TB again, term called INFECTION WITH HIV:HIV infection ‘RECURRENT TB’. DIABETES:directly increases the likelihood that new impairs the innate and adaptive infection with M.tuberculosis due to immune responses, thereby immune supression will progress accelerating the proliferation of TB. rapidly to TB disease among HIV- The aim: The aim of the study infected individuals, lifetime risk of was to demonstrate that patients developing active TB is with certain risk factors like HIV, 50%,compared to 5-10% in persons smoking, drinking and diabetes are who are not HIV- more prone to develop TB. Materials infected.SMOKING:more than 20 and methods:15 patients suffering 112

ISIC-2016 Abstract book from different forms of TB, like compared to other patients with Primary form of TB, patients,treatment was ineffective or Secondary form with disseminated slow because of presence of HIV TB and miliary TB admitted to infection. department of phthisiology and Conclusion: This shows us pulmonology were under my that patients with diabetes and those observation and were chosen for who are regular smokers and drinks further analysis. a lot are more prone to TB proving Results: After investigation I that these are risk factors of TB due found out that 6 of the patients were to which treatment was taking regular smokers and used to drink time.We can also say that TB patients very often and were also diabetic. having CO-INFECTION with HIV is And 4 patients were infected with the most dangerous risk factor of TB HIV. After treatment it was seen that as we saw that treatment’s 33% of patients who were not effectiveness is very low. To infected with HIV, nor they were decrease the risk of TB, people who diabetic and neither they smoke nor regularly smokes or drinks or having drink were having fast recovery.• In diabetes or are infected by HIV was seen in 40% of patients who should be under observation for TB. were having diabetes and were Flurography should be done regular smokers and use to drink regularly along with x-ray, CBC, lab very often that the treatment was test once in a year atleast to prevent taking time as compared to other severe form of TB because patients. In 27% HIV infected PREVENTION IS BETTER THAN patients improvement was least, CURE. very low recovery was seen,as

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ISIC-2016 Abstract book Guz Elena, Al Bhadili Laith Mousen, Mabroad Aws Falah CLINICAL SIGNIFICANCE OF PROSTAGLANDINS IN FORM OF COURSES OF BACTERIAL INTESTINAL INFECTIONS IN CHILDREN Research advisor: Dr.PhD Zharkova Tetyana Kharkiv National Medical University Department of children infection disiases

Actuality: Acute intestinal PG of serum were investigated by infections (ІI) are one of the most Elisa test. frequent infectious diseases for the Results: We found that all children. Certainly, that clinical sings patients had increased levels of PGE of any disease, including IІ, is and PGF2α in serum during disease determined by the reaction of that matches of activity mediators of inflammation, inflammatory reaction of organism. particular – interleukins and In an acute period in patients with prostaglandins (PG). The PG are able WLIІ the level of PGЕ (211,93±6,86) to disturbs the dynamic balance of of blood is considerably higher and antioxidant activity of lipids and PGF2α (65,69±2,07 pkg/ml) - below, antioxidant system, change a than for children with SLII (PGE peristalsis to the intestinal, vascular 206,38±4,79 pkg/ml, PGF2α tone. However there are only single 74,73±3,74 pkg/ml). We consider scientific works to the study of PG in that levels of PG of blood can be used forming of clinical variant of II. as prognostic criteria of course of II The aim: to set the value of on the early stage. In our opinion, prostaglandin (PG)E and F2α in exactly high level of PGЕ in a acute forming of clinical variant of period of patients with WLII and intestinal infections at children of weak activating of PGF2α in blood is early age cause of development of more Materials and methods: We expressive inflammatory reaction in observed 198 children (1–3 years) intestinal. This fact was confirmed by with II, of which 131 - the smooth- changes in caprological test. like (SL) and 67-wavy-like (WL) On the 6 – 7 day we registered course of the disease (98-shigellosis, decline of levels of PGЕ and increase 67-salmonellosis, 33–esherihiosis). - PGF2α in the serum for all patients, The 25 healthy children were control but for SLII was lowest level of PGЕ group. All patients determined the and highest level of PGF2α in levels of PGE and PGF2α in the blood, comparison with WLII. In our on the 1-3 day after onset of the opinion, this fact shows to unfinished disease, then on 6-7 day and in case inflammatory reaction in the of WLIІ on 12-14 day. The levels of organism of children, this is impotent for stages rehabilitation and clinical

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ISIC-2016 Abstract book supervision of convalescents. At the of concentrate of PG in blood of period of early convalescent on 12- patients with II at the early stages 14 day of the diseases the levels of and at the course of illness allows PG in patients with WLII were forecasting the variant of course. approached to the level of patients That will allow prescribing with SLII, but the time difference is therapeutic tactics of patients more 5-7 days. objectively. The high levels of PG in Conclusion: In the acute the convalescent period show to the period of II the levels of PG were unfinished inflammatory reaction in increase, that conform the active the organism. This fact we mast phase of the system inflammatory consider on the stages of further reaction of organism. Determination rehabilitation.

Ilyukha S., Parkhomenko J. THYROID STATE IN CASES OF PULMONARY TUBERCULOSIS Research advisor: Matveyeva S., PhD, Candidate of Medical Sciences Department of Phthisiology and Pulmonology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. An epidemic hormone are measured by immune- situation on tuberculosis (TB) in enzyme method in a blood stream. Ukraine is characterized by the high Results. Pathology of level of relapses of the disease. echostructure of thyroid is Because TB is immunodeficient diagnosed in 53, (33%) of new cases disease, and thyroid participates in of tuberculosis and in 60 (66%) of forming of immunity, we made cases previously treated. The level of comparative study of thyroid state in free thyroxine was significantly new cases of TB and cases previously lower and level of thyroid treated. stimulating hormone was Aim. To study a thyroid state significantly higher in persons in patients with new cases of previously treated comparing with tuberculosis and previously treated new cases. The percentage of cases. autoimmune thyroiditis and the Matherials and methods. in percentage subclinical 60 patients (30 persons with new hypothyroidism were higher in cases of tuberculosis and 30 persons persons previously treated previously treated) echostructure of comparing with new cases. thyroid is studied, and also the levels Conclusions. The changes of free thyroxine, thyroid stimulating found is the ground for recommendation to screen thyroid 115

ISIC-2016 Abstract book state in persons with tuberculosis relapsed and treatment failure.

K.V. Iurko, A.O. Solomennik, N.I. Khrystenko THE FEATURES OF LIPID METABOLISM IN PATIENTS WITH CHRONIC HEPATITS C Departnment of Infectious Diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Hepatitis C virus Statistical analysis was performed (HCV) is characterized by wide using the software package distribution and ability to cause «Statistica for Windows», 8.0. health disorders of the working Results. Study on the work population, thus causing significant carried out at the Department of morbidity and mortality worldwide. Infectious Diseases of Kharkiv Among the factors indicative of the National Medical University, located progression of chronic hepatitis C, at the Regional Clinical Hospital of the leading position belongs to Infectious Diseases of Kharkiv. TC in hepatic steatosis, which may be patients with chronic hepatitis C had virus-induced, and metabolic. HCV- no significant difference with that of infection is one of the major risk the control group in patients. The factors for metabolic disorders. patients studied, compared to the Materials and methods. The control, there was a significant content of lipid metabolism was increase of triglyceride, atherogenic determined in 36 patients with coefficient, LDL, VLDL and reduction chronic hepatitis C. The study of lipid HDL (p<0.001). In carrying out the metabolism of blood (total correlation analysis in patients with cholesterol (TC), triglyceride, High- chronic hepatitis C, a strong direct density lipoproteins (HDL), Low relationship between the level of density lipoproteins (LDL)) was CD4+ cells and the degree of increase carried out by the enzymatically- of triglyceride (r = 0,64, p <0.001) colorimetric method with diagnostic was established. kits from the company "SpaynLab" Conclusions. In patients with (Spain). The content of Very Low chronic hepatitis C significant Density Lipoproteins (VLDL) in increases in serum triglyceride, blood serum was determined by the atherogenic coefficient, LDL, VLDL formula: VLDL=TG/5. Atherogenic and HDL were observed. This coefficient (AC) was calculated by indicates a violation of lipid the formula: AC=(TC-HDL)/HDL. metabolism in studied patients.

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Egwakhide Adams, Zainab Akanni, Sorokina Olga A CURRENT REVIEW OF EBOLA HEMORRHAGIC FEVER Research Advisor: PhD Kucherenko Olena Department of Infectious Diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Ebola hemorrhagic symptoms. A negative test before fever (EHF) is an acute viral this does not rule out Ebola virus syndrome that presents with fever disease (EVD). IgM enzyme-linked and an ensuing bleeding diathesis immunosorbent assay, antigen- that is marked by high mortality in capture, polymerase chain reaction, human and nonhuman primates. and virus isolation are the diagnostic Fatality rates are between 50% and tests available to diagnose a patient 100%. Due to its lethal nature, this who presents at a health facility filovirus is classified as a biological within a few days of showing class 4 pathogen. symptoms. Supportive management Results. Pteropodidae families of infected patients is the primary of fruit bats are thought to be the method of treatment, with particular natural reservoirs of Ebola virus attention to maintenance of (EV), humans can be infected by EV hydration, circulatory volume, blood by direct contact with blood and pressure, and the provision of body fluids of infected animals such supplemental oxygen. In almost all as apes, gorillas, fruit bats, and outbreaks of EHF, the fatality rate monkeys there is no evidence that among health care workers was pet cat and dogs, mosquitoes, or higher than that of non-health care other insects can transmit EV. workers. Since there is no specific Human-to-human transmission treatment outside of supportive occurs via direct contact with the management and palliative care, blood, organs, secretion, and other containment of this potentially lethal bodily fluids (such as urine, faeces, virus is paramount. Prevention is a semen, breast milk, mucus, vomit) of very important tool in stopping the an infected person and via surface spread of disease especially as there and materials contaminated with is no FDA-approved vaccine available these fluids. Incubation ranges from for EVD. Prevention is achieved by 2 to 21 days. Patients who are able to careful practice of personal hygiene, mount an immune response to the avoiding contact with blood and EV will begin to recover in 7 to 10 body fluids and funeral ritual that days. EV usually reaches detectable require handling the body of levels in blood after 3 days of someone who has died from EVD; 117

ISIC-2016 Abstract book with bats and nonhuman primates or with the bodies of people who have blood, fluids, and raw meat prepared died from EVD. from these animals. Health care Conclusion. The public health workers who may be exposed to sector along with the respective chief people with EVD should wear authorities in developing countries appropriate personal protective must devise strategies, keeping the equipment. Practice proper infection available resources in mind, to deal control and sterilization measures. with the outbreak before it occurs. Avoid direct, unprotected contact

Elizabeth Ejagwulu, Fatima Abdur-Rahman, Al-Bhadili Laith-Muhsen RABIES Research Advisor: PhD Kucherenko Olena Department of Childhood Infections Kharkiv National Medical University Kharkiv, Ukraine almost invariably fatal. The virus Actuality. Rabies (R) is an replicates in striated or connective averiable viral disease caused by the tissue at the site of inoculation and rabid animal to the warm blooded enters peripheral nerves through animals especially human. According neuromuscular junction. It then to an estimation by WHO, almost spreads to the CNS in the 55,000 people die because of R every endoneurium of the Schwann cells. year. Dogs, cats and foxes are the Terminally, there is widespread CNS major reason behind this, involvement but few neurons approximately 99% human deaths infected with the virus show caused by dog's bites. Developing structural abnormalities. R divided countries are the victims of R. With upon three stages: prodromal, the post-exposure preventive excitement (furious) and paralytic regimes, 327,000 people can prevent (dumb). The first clinical symptom is this disease annually. neuropathic pain at the site of The Aim. To study the infection or wound due to viral methods of prevention and replication. Followed by the treatment of Rabies prodromal phase either or both the Results. The common mode of excitement or paralytic forms of the transmission of R is by bite of a rabid disease may be observed in the animal or the contamination of particular species. R can only be scratch wounds by virus infected confirmed by laboratory tests saliva. R is an acute infection of the preferably conducted post mortem central nerves system (CNS) which is on central nervous system tissue and 118

ISIC-2016 Abstract book also on the samples of saliva, serum, disease and requires strong and skin biopsies of hair follicles at the permanent prevention for every nape of the neck. There is no certain susceptible victim of a rabid bite. cure for R except supportive care. R Ways of prevention are: post- can be prevented before the latent exposure prophylaxis - should be symptoms can develop, consists of done if a person is bitten by an giving a person an injection of R animal (involved: washing immune globulin (Ig) and another thoroughly of wound and scratches injection of R vaccine as soon as with soap and water and after using possible after the bite or exposure to one dose of R immunoglobulin and saliva from an infected animal. five doses of R vaccine within the 28 Human R Ig is used or injected at the days period) and pre-exposure bite area immediately because it prophylaxis – it needs high risk attacks the virus and slow down or groups (veterinarian, animal stop viral progression through the handlers and laboratory workers, nerves. Untreated or inappropriately whose activities bring them in treated R is always fatal because contact with R virus or rabid treatment is not effective. The animals, international travelers solution is to use vaccination against likely to come in contact of the R. animals in the R threaten areas) Conclusions. To conclude, nowadays R is a very dangerous

Obi Chioma Annastasia HELICOBACTER PYLORY ERADICATION IN TREATMENT OF PATIENTS WITH ACUTE CENTRAL SEROUS CHORIORETINOPATHY Research advisor: Zubkova Darya, Dr Department of ophthalmology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Although the more often in patients with central majority of cases of central serous serous chorioretinopathy. chorioretinopathy are self-limited, The aim was to estimate the resolving spontaneously after a clinical efficiency of helicobacter number of weeks, the recurrence Pylori infection eradication in rate is estimated to be 20% to 50%, treatment of patients with central some cases will be chronic, lasting serous chorioretinopathy. six months or longer. The evidence of Methods. 93 patients with acute Helicobacter pylori infection appears central serous chorioretinopathy participated in this study. Patients 119

ISIC-2016 Abstract book were divided into experimental improvement distant prognosis after group (33 helicobacter Pylori 2 years: visual acuity increasing in positive patients who received 1,2 times (р=0.03), decreasing of eradication treatment) and two scotoma frequency in 2,4 times control groups who did not receive (р=0.02) and scotoma size in 1,9 eradication treatment: 29 times (р=0.04), decreasing of helicobacter Pylori positive patients metamorphopsia frequency in 1,3 and 31 helicobacter Pylori negative times (р=0.03) and color pathology patients. Research methods were in 1,6 times (р=0.04); positive best-corrected Snellen visual acuity, dynamic with complete resorbtion of optical coherence tomography on the subretinal fluid was marked after 3 «SOCT Copernicus» and fluorescein months in all patients with central angiography. serous chorioretinopathy. Results. The helicobacter Pylori Conclusions. The Helicobacter eradication caused decreasing of Pylori eradication is effective in disease duration on 3 months treatment of Helicobacter Pylori (р=0.04) and recurrence frequency positive patients with central serous on 45,6 % (р=0.03) as well as chorioretinopathy.

Ogbu Odira .F CHIKUNGUNYA FEVER AND WHY IT SPREADS FASTER THAN OTHER VIRUSES. Research advisor O.I Mohylynets Department of infectious disease Kharkiv national medical university, Kharkov, Ukraine travel of infected individuals Actuality. Chikungunya is an between regions where competent arthropod borne mosquitoes exist for perptuation of virus(arbovirus)endemic to west local transmission.During this period africa that causes acute febrile the virus must replicate and reach polyarthralgia and arthritis. The the mosquito salivary gland so that it name is derived from tanzanian will be transmitted to a new host language meaning “that which bends when the mosquito takes the next up ”Epidemiology is endermic in part blood meal.This virus is most often of west Africa ,where it maintains in spread to people by aides aegypti cycle involving humans, aides and aedes albopictus mosquitoes mosquitoes, primates ,and others.it ,and this mosquitoes get infected has been identified in over 60 when they feed on a person already countries in Asia, Africa, Europe and infected with chikungunya virus. American.It spreads by means of Chikungunya fever is transmitted 120

ISIC-2016 Abstract book rarely from mother to newborn, till contractedf it,mainly in Caribbean. date ,no infants have been found to We are in century of migrations and be infected with chikungunya virus frequent travel,and consequently in a through breastfeeding. After bite of context where diseases spreads an infected mosquito ,onset of illness rapidly. To date,30 countries in the occurs usually between 4-8days but Americas have been affected- can range from 2-12days.The clinical argentina is the most recent. signs and symptoms begins abruptly Conclusion: symptoms of with fever and malaise following an chikungunya are similar to those of incubation period of 2-4days.Fever dengue and zika virus because they maybe high grade (40degree )usual are transmitted by same species of duration 3-5days.Polyarthralgia mosquitoes.so they should be begins 2-5days after onset of fever differentiated properly .chikungunya and commonly involves multiple virus should be considered in joints .Arthralgia is symetrical and patients with acute onset of involves distal joints more than persistent fever and polyarthralgia, proximal, Pain is intense which also especially travellers who recently can lead to immobilisation.Skin returned from areas with known manifestation ,with most common virus transmission. Dengue fever: being macular or macular papular they both share some clinical rash usually appearing 3days or later symptoms ,however polyrthralgia is after onset of illness and lasting 3- not typical for dengue fever. 7days.There is no specific antiviral Cytopenia particularly treatment for chikungunya fever thrombocytopenia may distinguish ,treatment is directed primarily at dengue from chikunguya fever. Zika relieving symptoms ,including joint virus: chikungunya presents with pain and fever with antipyretics, higher fever and more intense optimal analgesics and fluids. There arthralgia than zika virus. Diagnosis is no commercial chikungunya is established by pcr. Enteric fever: vaccine . the presentation of enteric fever is Results. Chikungunya fever is typically subacute but chikungunya spreading more rapidly through is abrupt onset. Leptospirosis: is Latin America, the virus has killed distinguished from chikungunya by 21people and infected some 6000 in presence of conjuctival effusion and the region. The first cases was jaundice. Malaria: fever in malaria is detected in late 2013,so far, an intermittent whereas in chikugunya estimated 500,000 people have is persistent fever.

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ISIC-2016 Abstract book Ogunyemi Opeyemi Oluwafunmilayo INVESTIGATION OF INCREASING INCIDENCE OF EXTRAPULMONARY TB IN NIGERIA Research Advisor: PhD Choporova A. Department of Phthisiology and Pulmonology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Nigeria is one of the acid fast bacillus in collected high tuberculosis (TB) burden sample.Patients or guardian were countries, and reports one of the informed about participation in the highest incidence rates of extra- study with the right not to pulmonary TB dominated by cervical participate. lymphadenitis (TBLN) and Results: During the study abdominal TB. period, 90 patients with Aim: To investigate the extrapulmonary tuberculosis were increasing incidence of diagnosed and treated. 59 of the extrapulmonary tuberculosis in patients were HIV positive(53-TBLN, Nigeria and find the correlation 5-abdominal TB, 1-uterine TB). No between its rising incidence and HIV- major patient or bacterial strain coinfection. factor could be identified as being Materials and Method:The responsible for the high rate of research was conducted among a TBLN. Analysis of the demographic group of patients with data of involved patients showed extrapulmonary tuberculosis that having regular and direct registered in the out-patient clinic of contact with live animals was more a Research Institute in Nigeria, associated with TBLN, abdominal TB between the years 2011-2014.The and cutaneous TB than with PTB. demographic & clinical Mycobacterium bovis was isolated characteristics of 60 TBLN patients from most patients with abdominal and 25 abdominal TB patients, 3 TB, but not from those with TBLN. cutaneous TB patients and 2 uterine Majority (≈90%) of patients who TB patients were studied. Detailed presented with abdominal TB were examination was carried Northern Nigerians amongst-whom out.Western blot tests were cattle-rearing and intake of raw milk performed to check HIV status. is a very common cultural practice, Histological examination of biopsy this suggests that infection with material was carried out in every Mycobacterium bovis should be case. Diagnosis of TB was made by included as one of the main reasons histological or cytological for the high rate of extrapulmonary examination or demonstration of TB in Nigeria. All 3 cases of

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ISIC-2016 Abstract book cutaneous tb were also amongst Conclusion: The increasing northern Nigerians. In these patients incidence of extrapulmonary the incidence showed little tuberculosis in Nigeria can be association with HIV coinfection. The associated with the rapidly incidence of TBLN was higher worsening HIV/AIDS epidemic and amongst patients with HIV bad economic condition in the coinfection (88.3%). People of low- country. It is possible that income groups were found to be extrapulmonary TB has always had a more commonly affected, confirming high incidence in places where the higher prevalence in cattle-rearing and drinking of raw overcrowded, unhygienic living cow milk are common cultural conditions and possibly malnutrition practices. (55.6%).

Olkhovskyy Evgen, Al-Karawi Ahmed Shakir EPSTEIN-BARR VIRUS INFECTION IN CHILDREN: A RETROSPECTIVE ANALYSIS Research advisor: Professor Kuznetsov Sergey Department of children infectious diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality: In the recent Aim: The main aim of our decades, the persistence of study was a retrospective analysis of herpesvirus infections was noticed , the liver in patients with persistent including those caused by Epstein- EBVI. Barr virus, occupying one of the main Materials and methods: We children's infectious diseases, conducted a survey of 54 children affecting not only the course of other aged 1-6 year-old who had persistent infectious diseases, but also to EBVI through 1-2-3-6 months after physical development of the child in discharge from the hospital where general. Considering the fact that the they were treated on the active children with infectious phase of EBVI (severe form). In mononucleosis often discharged addition to the observation, the from the hospital with an children underwent ultrasound of improvement of the general the liver and liver function test. condition, but with preservation of Result: After one month study the structural and functional changes showed that 43 (79.63%) of children in the liver. have preserved liver parenchymal reaction with increased echogenicity 123

ISIC-2016 Abstract book to 10 gradations, 8 (14.82%) - the four cases of periportal phenomenon of hepatosplenitis, 10 lymphadenitis and mesadenitis (18.52%) - periportal lymphadenitis, (7.41%). The slight increase in ALT in 11 (20.37%) – abdomenal level determined in 15 (27.77%) mesadenitis phenomenon. According children, indicating preservation of to the results of liver function tests in the phenomena of cytolysis. A survey 36 (66.67%) of children appeared to of children six months later revealed have the phenomena of cytolysis the presence of liver parenchymal with increased ALT level. A survey of reaction in 15 patients (27.77%), no children at second month showed cases of hepatosplenitis, in three preservation of liver parenchymal cases of periportal lymphadenitis reaction with a slight increase in remained (5.55%) and four children echogenicity of the tissue in 35 preserved the phenomenon of (64.81%) of children, the abdominal mesadenitis (7, 41%). phenomenon hepatosplenitis - 4 Conclusions: in children with (7.41%), periportal lymphadenitis - persistent EBVI ,for long time 6 (11.11%), phenomenon preserved the changes of structural mesadenitis - 7 (12.96%). and functional state of the liver, Manifestations of cytolysis were which should be considered at the observed in 25 (46.3%) of children. stage of follow-up, to concern about Positive dynamics was observed on in course of rehabilitation therapy the third month of study: liver with hepatoprotectors, take into parenchymal reaction was account the above specified changes determined in 20 (37.04%) patients, when combination with any other one case hepatosplenitis (1.85%), infectious disease.

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ISIC-2016 Abstract book Omakagu Emmanuel, Andrew Trizhelik Agnes ZIKA VIRUS DISEASE Research Advisor: PhD Kucherenko Olena Department of Childhood Infections Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Zika virus (ZV) is a conjunctivitis, and joint pains. Three member of the virus family well-documented cases of ZV were Flaviviridae and the genus Flavivirus. described in brief in 1954, whereas a It is spread by daytime-active Aedes detailed description was published mosquitoes, such as A. aegypti and A. in 1964; it began with a mild albopictus. ZV is related to dengue, headache, and progressed to a yellow fever, Japanese encephalitis, maculopapular rash, fever, and back and West Nile viruses. It’s name pain. Within two days, the rash comes from the Zika Forest of started fading, and within three days, Uganda, where the virus was first the fever resolved and only the rash isolated in 1947. The virus spread remained. Thus far, Zika fever has eastward across the Pacific Ocean been a relatively mild disease of 2013–2014 Zika virus outbreaks in limited scope, with only one in five Oceania to French Polynesia, New persons developing symptoms, with Caledonia, the Cook Islands, and no fatalities, but its true potential as Easter Island, and in 2015 to Mexico, a viral agent of disease is unknown. Central America, the Caribbean, and For differencial diagnosis we have to South America, where the Zika remember that the symptoms of Zika outbreak has reached pandemic are similar to those of dengue and levels. As of 2016, the illness cannot chikungunya, diseases spread be prevented by medications or through the same mosquitoes that vaccines. transmit ZV. The Aim. To study methods of Conclusion. ZV is related to yellow prevention and treatment of Zika fever, Japanese encephalitis, and virus disease. West Nile viruses. There is no Results. ZV may spread from a vaccine to prevent or medicine to pregnant women to the baby. This treat ZV. Recomendations: Get plenty may result in microcephaly and of rest. Drink fluids to prevent other severe brain problems. ZV dehydration. Take medicine such as infections in adults can result in acetaminophen or paracetamol to Guillain-Barré syndrome. Common reduce fever and pain. Do not take symptoms of infection with the virus aspirin and other non-steroidal anti- include mild headaches, inflammatory drugs until dengue can maculopapular rash, fever, malaise, be ruled out to reduce the risk of

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ISIC-2016 Abstract book bleeding. To conclude, ZV disease is a people to avoid it. very dangerous disease today and strong prevention of it can help

Onuchukwu Chibuzor, Burtov Dmytro, CHARACTERISTICS OF MULTIDRUG-RESISTANT TUBERCULOSIS IN NIGERIA Research Advisor: Medical Doctor Bassey Udoema Department of Phthisiology and Pulmonology Kharkiv National Medical University Kharkiv, Ukraine prepared using Ziehl-Neelsen and Introduction: Nigeria is ranked the specimen considered of best tenth recently among countries with quality out of the three collected was highest burden of tuberculosis (TB) cultured on an automated BACTEC in the world, with an annual 960 Mycobacterium growth incidence of 311 cases per 100,000 indicator tube DST was conducted population and a mortality rate of using four anti-TB drugs – 81 per 100,000 population even with streptomycin, isoniazid, rifampicin the use of Directly Observed Therapy and ethambutol. Cultures were Short Course (DOTS) Strategy. Drug incubated at 37C for up to 42 days sensitivity survey was conducted and confirmed. using automated BACTEC cultures Result. 117(males 59; females and drug susceptibility testing 58) patients with chronic cough (DST) of patients with features of were investigated during the study pulmonary TB in Nigeria at the period of these, 31 had smear- Research Laboratory of Zankli positive TB. 72 patients had positive Medical Centre (ZMC) in Abuja. sputum culture, although M. The aim of our study was to tuberculosis complex isolates were investigate characteristics of only confirmed in 39 of these and 4 Multidrug-resistant tuberculosis in were deemed to be contaminants, Nigeria. leaving 35 specimens for analysis of Materials and methods. One DST. DST was performed in 32 of the hundred and seventeen (males 59; 35 isolates; 10 (31%) were resistant females 58) patients with chronic to at least one of the four drugs cough were investigated during the tested and 4 (13%) were resistant study period Three sputum samples to the four drugs tested and were were collected and were examined at classified as multidrug resistant-TB ZMC with automated BACTEC TB (MDR-TB). Seven of the 19 (37%) culture and susceptibility in Abuja, HIV-positive and 3 of the 12 (25%) Nigeria, Sputum smears were 126

ISIC-2016 Abstract book HIV-negative patients had resistant infection was found. MDR-TB is isolates to any of the four drugs. present in Nigeria and larger studies Conclusion. This study are urgently required Adequate confirms that there is a high measures should be put in place to prevalence of Multiple TB drug provide second-line drugs, resistance in Nigeria, Ten (31%) of supervision of drug distribution and 32 culture-positive patients were compliance, enforcement of DOTS resistant to at least one and four protocols and continued training of (13%) to all of the four drugs tested, all personnel in TB management and No association between drug care. resistance and human immunodeficiency virus (HIV)

Patel Priyanka Harishchandra, Isa Mashkur Abdulhamid THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL AGE CHILDREN WITH SEVERE ASTHMA Research advisor – Doctor of medicine Bezrukov L.O. Department of pediatrics and children’s infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine

Actuality. A major challenge examined in the pulmonology among modern pediatric allergic department of Chernivtsi Regional diseases is bronchial asthma. Children's Clinical Hospital. The Assigning asthma control therapy to study involved 30 pupils with severe children should be considered based asthma and 30 children with on the phenotype. Hence, moderate course. The content of performance of atopic reactivity in serum total immunoglobulin E(IgE), children that reflect the specific IL-4 and IL-5 were determined by pathogenic mechanisms of asthma enzyme-linked immunosorbent will personalize treatment and thus assay (ELISA). Determination of improve management of asthma. immediate type skin sensitivity to The aim to increase the nonbacterial standard allergens was effectiveness of treatment of severe performed by intradermal tests. To asthma phenotype in school-age study atopy, standard household, children, taking into account the epidermal, pollen and food allergen diagnostic value of atopic reactivity was used.Clinical and indicators. epidemiological risks, as well as the Materials and method: 60 diagnostic value of individual school-age children suffering from indicators of atopic reactivity for asthma were comprehensively severe asthma phenotype 127

ISIC-2016 Abstract book verification were defined. (Pφ<0.05) of the second. Results: About one in three Conclusion: The phenotype of patients (36.4%) with the phenotype severe asthma raises the risk of of severe asthma recorded increased content of IL-4 and IL -5 in significantly increased content of IL- serum by 3.1 times. However, this 4 (more than 10.0 pg/ml), while only paraclinical test is 15.5% in the second group rather suitable for verification of this (Рφ<0.05). There was increased risk phenotype (Sp – 84.6% (95% CI of relatively raised content of IL-4 75.9-91.1)) than for its detection (Se and IL-5 in serum of patients with – 36.4% (95% CI 26.9-46.6)). severe asthma. Almost every second Concentration of total IgE in serum child suffering from severe asthma of more than 545.3 IU/ml in children noted increased concentration of IgE doubles the chances of severe (>545.3 IU/ml). There were asthma being present. Increased significantly more frequent cases of sensitivity to domestic allergens hypersensitivity to household (hyperemia more than 15.0mm) allergens in the group of patients allows severe asthma specificity with severe asthma. Thus, a verification (81.5%) and hyperaemia of more than 15.0mm personalization of treatment policy was recorded in 81.5% of children of in these patients. the first group and only in 51.9%

Popovich N. CONTEMPORARY ASSESSEMENT OF ENTEROSORBENTS Research advisor: prof. Tereshin V. A. Department of Infectious Diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality. In recent years, the enterosorbents used in modern problem of endogenous intoxication medicine. (endotoxemia) became acute and Materials and methods. urgent that is why the extracorporeal Contemporary scientific literature. blood purification is the branch of Results. The main positive studies that is developing now. effect of enterosorption is an active The aim is to analyse detoxification, based on the contemporary scientific literature allocation of factors of endogenous on this subject, describe the kinds of intoxication through the gastrointestinal tract via oral 128

ISIC-2016 Abstract book sorbents. In total there are 4 from 70 to 1000 daltons (urea, generations of enterosorbents. The bilirubin, cholesterol, midmolecule 1-st generation is carbon adsorbents peptides). The 4-th generation is (Charcoal, Sorbeks). It is silicon highly dispersed sorbents characterized by the fact that (White Charcoal). The mechanism of medications that belong this sorption is based on electrostatic generation have small pores and interaction. Particles of silicon adsorb small molecules: water, dioxide block the agglutination vitamins, amino acids and minerals . centres of pathogenic The 2-nd generation is polymeric microorganisms. sorbents (Polyphepan, diosmectite). Conclusion. The application of It represents a plate with a gap of 1 enterosorbents based on silicon nm between layers, which also dioxide (SiO2) in clinical practice has makes impossible the sorption of several positive pharmacological medium and large molecules. The 3- effects compared to other groups of rd generation is silicon and hydrogel sorbents due to its high adsorption sorbents (Enterosgel, Polisorb, White capacity, high speed of binding of Clay, Smecta). The skeleton of the gel microorganisms and bacterial toxins, consists of globules, the pores possibility of ingestion in moderate represent empty spaces between the therapeutic doses, large area of the globules, binding of substance may active surface and immediate be in a range of molecular weights therapeutic effect.

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ISIC-2016 Abstract book Serdiuk V. Kozlovа K. COMPARAIVE CHARACTERISTICS OF DIFFEREN GENERAIONS OF CEPHALOSPORINS AT TREATMENT OF TONSILLITIS Research advisor: Tereshyn V Second Scientific adviser ass.prof. Merkulova N.F. Department of infectious diseases Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Tonsillitis is an that the duration of fever from the acute infectious disease, it takes onset of the disease in patients third after influenza and other acute treated with Cedex, averaged 5,4 ± respiratory infections. It is one of the 0,53 days, Cefazolin - 6,0 ± 0,50 days leading places in the temporary (p> 0.05). The duration of elevated disability of the population. It can body temperature period from the cause a lot of complications: start of antibiotic therapy showed rheumatic fever, myocarditis or that individuals group I this figure glomerulonephritis. was 4,3 ± 0,35 days, patients in The aim of this work was to group II - 4,8 ± 0,47 days (p> 0.05 ). study the comparative Symptoms of intoxication in patients characteristics of different of group I have been recorded over generations of cephalosporins in the 4,5 ± 0,32 days in group II - 4,9 ± treatment tonsillitis. 0,35 days. Sore throat was founded Material and methods. It was 2,3 ± 0,35 days in patients of group I, retrospective analysis. We used case 2,5 ± 0,40 days - group II, raids on histories of different patients with the tonsils held were located 3,5 ± tonsillitis in age from 20 to 55 years. 0,11 and 3,6 ± 0 15 days, All cases were divided into 2 groups. respectively. Increased regional The first group consists of 20 lymph nodes about 1.5-2 sm in patients. They received Сedex diameter have been observed within (third-generation cephalosporins) at 5,7 ± 0,35 days in patients treated a daily dose of 400 mg. The second Cedex, somewhat more 6,1 ± 0,40 group consists of 25 patients. They days - patients treated Cefazolin (p> received Сefazolin (first-generation 0.05). cephalosporins) at a daily dose of 1 The germs of pathogenic g. As a result of studies bacteria were microorganisms absent in 85% of of found : Str. pyogenes , Staph. aureus, patients who received Cedex, and H. inflyenza, Str. pneumoniae, 80% of patients who received Klebsiella pneumoniae. Cefazolin after treatment with Results. In the process of antibiotics. dynamic observation, it was found

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ISIC-2016 Abstract book The average duration of cephalosporin Cedex has a hospitalization was in the first group pronounced antibacterial effect in - 11,3 ± 0,49, while the second - 12,1 comparison with the first-generation ± 0,30. cephalosporin Cefazolin. Cedex is Conclusion. As a result of the more effective in eliminating the research we got to the following clinical manifestations of tonsillitis conclusions: the third-generation compared to Cefazolin.

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ISIC-2016 Abstract book Shcherbich J.V. EXTERNAL TREATMENT OF LIGHT COURSE OF ACNE DISEASE IN THE ACUTE STAGE Research advisor - Candidate of Medical Sciences Nalizhytyy A.A. Department of skin and venereal diseases, Vinnytsia National Pirogov Memorial Medical University, Vinnytsia, Ukraine

Actuality. Statistics shows that acute stage were examined and currently acne disease takes the treated. All had open and closed third place in frequency of appeals to comedones on face, papules and the dermatologists. It is especially pustules on different stages of spread among adolescents and development.Gel Deryva C, which young people. According to was applied with a thin layer on scientists,80% of the population clean, dry skin 1 time per day in the aged 12 to 25 years has this disease. evening was used as external Changes in the endocrine system, therapy. Effaclar Duo (+) corrective intensive production of sex remedy was used with a thin layer 1 hormones, including androgens that per day in the morning to reduce a increase the production of sebum are comedogenic. All patients were the main causes of acne during this prescribed a local laser therapy with period. Pathological follicular a wavelength of 380 - 420 nm and hyperkeratosis, Propionbacterium 650 - 660 nm 1 per day. At the acnes growth and opportunistic beginning and after five weeks of pathogens - Staphylococcus treatment the estimation of epidermidis, Staphylococcus aureus, dermatological life quality index inflammatory process in general (DLQI - Dermatology Life Quality plays an important pathogenetic role Index) was made. . Thats why, treatment should be Results: The positive complex and should affect all these dynamics of reducing of acute parts. inflammation and the number of The aim. To investigate the lesions were showed after the first effectiveness of local combined week of treatment. The maximum treatment of light course of acne therapeutic effectiveness was disease in the acute stage using noticed from the 4-5-th week of Deryva C remedy, Effaclar Duo (+) treatment.The 7-th week of correction remedy and laser therapy, treatment was accompanied by dry determine the dermatological life skin, which was successfully quality index (DLQI) of patients. corrected by Effaclar Duo (+) remedy Materials and Methods:14 in most patients.The by-effects were patients aged 15 to 31 years with not found during the researching. At light course of acne disease in the the same time a significant decrease 132

ISIC-2016 Abstract book of the DLQI index was noticed with safe method of treatment of light the improvement of clinical course of acne disease, has anti- symptoms. So, before the beginning comedone and anti-inflammatory of the treatment people`s DLQI was action, helps to prevent the 15,2 ± 0,53, and after treatment it appearance of new lesions. The use was- 7,3 ± 0,88,thus it decreased in of the proposed treatment has 2,08 times. greatly improved the quality of life of Conclusions: The proposed patients with acne,about what a combination of external treatment decrease of DLQI index shows. and laser therapy is an effective and

Sokhan A.V., Gvozdeckaya M.G., Urko K.V., Gavrilov A.V., Hasanova A. CLINICAL AND LABORATORY FEATURES OF ACUTE NEUROINFECTIONS IN HIV-POSITIVE PATIENTS. Research Advisor: Doctor of Medical Sciences, Professor Kozko V.N., Gvozdeckaya M. Department of Infectious Diseases Kharkiv National Medical University Ukraine, Kharkiv

Actuality. Clinical infectious CNS lesions in this group presentation of neuroinfections in of patients. HIV-infected includes a wide Matherials and Methods. spectrum of manifestations from Analysis of cerebrospinal fluid of asymptomatic infection to a patients by PCR which have features symptomatic and severe illness. of acute neuroinfections in HIV- Central nervous system involvement positive patients should be always considered as a Results. In recent years CNS severe clinical form in HIV-infected. lesions observed in 42,5% of Physicians should be aware to the patients. Through examination of broad clinical spectrum of cerebrospinal fluid of patients by neuroinfections in HIV-infected PCR was confirmed etiology of CNS patients. In the Kharkiv region all infections: toxoplasmosis in 19,9% of HIV - infected patients with patients, herpes simplex virus in infectious diseases that require 2,0%, cytomegalovirus in 13,2%, hospitalization hospitalized in Epstein - Bar virus in 18,5%, herpes- regional clinical infectious diseases zoster virus in 2,8%, cryptococcosis hospital. Experience of recent years in 7,4% and mycobacterium demonstrates the relevance of tuberculosis in 9,3% of cases. In

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ISIC-2016 Abstract book 10,0% of patients mix-infection was characterized by progressive diagnosed. Despite the use of dementia, cognitive disorders and modern methods of diagnosis of CNS paresis. etiology remained unclear in 45.7 % Conclusion. In HIV-infected of patients. This certainly reduces patients, we can see no change in the the effectiveness of treatment, clinical analysis of CSF. Even in increase the risk of complications patients with acute neuroinfection and deaths. Almost all HIV-infected observed only increased protein patients has subacute or chronic level and a slight increased level of course of the neuroinfection, with lymphocytes. The absence of slightly pronounced or even absent significant changes to show features meningeal symptoms and syndromes of infection in the central nervous of intoxication, which is not typical system in HIV-infected show low for immunocompetent patients. informativeness of routine clinical Clinical symptoms of CNS infectious tests in this group of patients. lesions in HIV-infected are usually

Sokhan A.V., Ansyferova N.V., Gavrilov A.V., Dudnik A.U. DIAGNOSTIC VALUE OF NEURON SPECIFIC ENOLASE (NSE) LEVEL IN CEREBROSPINAL FLUID OF PATIENTS WITH ACUTE BACTERIAL MENINGITIS. Kharkiv national medical university (infectious diseases department), Ukraine, Kharkiv

Bacterial meningitis occupies the neurospecific protein levels in a special place in the structure of patients with acute neuroinfections. acute neuroinfections. These To evaluate the diagnostic value and diseases are not only high rates of the degree of destruction of neurons mortality but frequent in adult patients with bacterial complications. As a marker of tissue meningitis, we determined the CSF damage to the brain is suggested to level of NSE in the course of the use different neurospecific proteins disease. The comparison group entering into the neural and glial consisted of 12 patients with acute tissue. In studies of recent years respiratory infections and shows the diagnostic value of meningism. We observed 54 patients increasing the concentration some with acute bacterial meningitis. neurospecific proteins in CSF and Among them 26 – with blood of patients with stroke, pneumococcal and 28 – with traumatic brain injury, diseases with meningococcal etiology of the demyelization. However, no data on disease. Among them, 15 (27.8%) 134

ISIC-2016 Abstract book showed moderate severity, 39 moderate severity level of NSE in (72.2%) – severe course of disease. CSF of patients with meningococcal In 7 (12.96%) patients the disease meningitis was 18,20±1,97 mg/l, ended lethally. Severity was mainly pneumococcal – 20,28±1,91 mg/l, in due to the development of cerebral severe – 25,57±2,55 mg/l and, edema, an infectious-toxic shock and 22,94±1,62 mg/l (P<0,01), in focal neurological symptoms. All patients with fatal consequences – patients with severe disease at the 28,93±0,88 mg/l (P<0,001 and time of admission were observed P<0,01). In all patients with cerebral edema symptoms of varying pneumococcal meningitis in acute severity. The obtained data show a phase of the disease CSF levels of significant increased NSE level in NSE was significantly higher than in cerebrospinal fluid during the acute the control group (P<0,001). phase of the disease. NSE level was Increased levels of NSE in patients not significantly dependent on the with acute bacterial meningitis, etiology of the process, but it depending on the severity of the depended on the severity of the disease demonstrates the presence disease – the highest levels were of neuronal damage that is important observed in patients whose disease diagnostic and prognostic marker. has ended lethally. In a group of

Elzahra Mohamed STIGMATIZING INFECTIOUS DISEASES Karrary University (medicine collage) Sudan, Khartoum

Actuality. Stigma is a mark of Results. Stigmatizing infectious disgrace that sets a person apart. diseases include: hepatitis, AIDS, When a person is labelled by their tuberculosis, Sars and others. People illness they are seen as part of a with such diseases suffer from stereotyped group. (According to feeling of shame and they may get WHO). frustrated and disappointed because The Aim. To focus the light on the of unacceptable attitudes from silence sufferance of patients with people toward them. Some people stigmatizing infectious diseases in are afraid of getting infected so they order to create an awareness in the prefer to stay away, others despise community of the infectious diseases those patients especially whom with and how people must deal with AIDS/HIV, less people are aware them. enough of the various infectious

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ISIC-2016 Abstract book diseases and their transmission practitioners specialized in testing ways. blood samples of patients refuse Through the ages, many testing samples of patients who are stigmatizing infectious diseases were susceptible to such an illnesses. associated with epidemic illnesses Best recommended solution is such as colera and chicken box. to raise the awareness of the entire Patients were held in the quarantine society in general and the employers till they die or recover, but even if in the medical fields in specific. they recover they face Barriers when People must get the knowledge of dealing with the refusing unaware the ways of infections spreading, and society. the possibility of treating several However, what makes the types of infectious diseases and the problem bigger or simpler is the preventing processes that they may doctors and medical care use to stay far away from diseases. practitioners who deal with the Conclusion. Patients as well patients, because their behaviour has need to be educated enough and a direct impact on the progress of the have the required information about patient’s psychological and their diseases in order to be able physiological health. coexist with them and participate in According to the bioethics the treating journey in an effective principles in the clinical practice, way. Qualifying centers may be practitioners in the medical field are successful in such issues. A patient not allowed to refuse treating with a confident is much easier been patients with such diseases. But this helped and treated than a patient is not always the truth, a trustful with shame. resources have proved that some

Tikhonova Olga, Adamsky Mark CLINICAL CRITERIA FOR DIAGNOSIS OF CEREBRAL TOXOPLASMOSIS IN HIV-INFECTED PATIENTS Research advisor: Solomennyk Ganna, the candidate of medical Sciences Department of infectious diseases Kharkiv national medical university, Kharkiv, Ukraine

Actuality. HIV infection AIDS, 38 % is toxoplasmosis acquired in the world pandemic infection. properties. Among all opportunistic The aim of the present study is diseases arising on a background of to improve the diagnosis of the CNS lesion caused by T. gondii, occurs in 136

ISIC-2016 Abstract book HIV-infected persons, based on a 6.1%, disorders of higher integrative comprehensive clinical studies. functions such as memory loss - in Matherials and Methods. 21.2% of patients. Meningeal Clinical-anamnestic information of syndrome was defined by stiff neck - CNS disease in HIV-infected persons, at 39.4% and Kernig symptom - in caused by T. gondii. 45.5% of patients. Motor abuse as Results. After studying hemiparesis, paraparesis and histories of the disease, it was found tetraparesis were present in 48.5%, that the disease started slowly, epileptiform syndrome - in 27.3%. patients came to the hospital on Abnormal reflexes were found in average (88,0 ± 21,2) day after onset 21.2% of patients of disease. Most came to the hospital Conclusion. The affection of in moderate condition - 69.7% of the CNS induced by T. gondii in HIV- cases. In severe condition - 24.3% infected people develops cases and in satisfactory condition - encephalitis. Most patients came to 6%. The duration of the time from the infectious hospital in moderate diagnosing of HIV infection to the condition and with a clear appearance of the first conscience. The main complaints are manifestations of T. gondii CNS weakness, mild diffuse headache, affection was in average (2,2 ± 0,6) nausea and often vomiting. An years. objective examination of patients An objective examination of shows most often weakness in the patients defined by disorientation in limbs, epileptiform and vestibular- place, time and personality - in atactic syndromes, disorders of 27.3%, psychomotor excitation in higher integrative functions.

Tregub E. CHANGES IN NITROGEN OXIDE IN PATIENTS WITH DESTRUCTIVE RECURRENT PULMONARY TUBERCULOSIS UNDERGOING THE INTENSIVE PHASE OF ANTI-TUBERCULOSIS THERAPY Research advisor: Butov D., PhD, Candidate of Medical Sciences Department of Phthisiology and Pulmonology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The determination been ascribed an important role in of nitrogen oxide status in patients immune response to TB. may contribute to the diagnosis of Aim. To study changes in tuberculosis (TB) and to determining nitrogen oxide (NO) in patients with the effectiveness of treatment and destructive recurrent pulmonary prognosis since nitrogen oxide have tuberculosis (RPTB) undergoing the 137

ISIC-2016 Abstract book intensive phase of anti-tuberculosis levels were significantly higher in therapy. 3rd group compared to 1st group, Matherials and while lowest levels were in 2nd methods. 198 patients were group. After two months of screened for TB: 71 patients with treatment the 1st group had iNOS destructive RPTB (1st group), 29 (104±3.30), nitrate (44.63±1.05), patients with RPTB without nitrite (4.41±0.10), 2nd group iNOS degradation (2nd group), 98 patients (85.21±2.98), nitrate (37.17±1.52), with newly diagnosed destructive nitrite (3.70±0.10), 3rd group iNOS pulmonary TB (NDPTB) (3rd group) (91.86±1.19), nitrate (41.41±0.90), and 30 healthy donors (4th group). nitrite (4.14±0.07) meaning that the All patients at admission had difference between baseline and infiltrative pulmonary TB. NO status post-treatment was significant was evaluated by measuring by (p<0.05). After two months of spectrophotometry the inducible NO therapy patients in 2nd group had synthase in neutrophils (iNOS), significantly more pronounced nitrite and nitrate levels in samples decrease in NO than 1st group. of venous blood prior treatment and Conclusions. In patients with two months later. pulmonary TB had significantly Results. At entry, the contents higher output in NO than in healthy of NO in 1st group iNOS (231.6 ± controls. Before treatment initiation 7.74) pmol\min\mgB, nitrate (56.35 patients with RPTB had significantly ± 1.09) mmol/l, nitrite (5.40±0.11) lower rates of NO than in patients mmol/l; in 2nd group iNOS with NDPTB. After 2 months on (307±8.46), nitrate (63.18±1.48), chemotherapy patients with nitrite (6.24±0.17); in 3rd group pulmonary TB had significantly iNOS (251.7±6.34), nitrate lower NO activity. There were (61.82±1.35), nitrite (5.77±0.11) significant differences in the indices values were significantly different NO between patients with (p<0.05); compared to 4th group destructive and without destructive iNOS (81.03±2.36), nitrate RPTB. (37.98±1.30), nitrite (3.83±0.09). NO

Vashchenko V. N., Kulinchenko G. M., Luchko N.O. SUPERSHARP COURSE OF FULMINANT HEPATITIS B. CLINICAL CASE. Research advisor: Bondar A.E., Candidate of medical science Infectious Diseases Department, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. The fulminant course disease, which is characterized by of acute hepatitis B is a severe rapid development of acute liver 138

ISIC-2016 Abstract book failure with the accession of hepatic Laboratory data: a sharp rise in ALT, encephalopathy and DIC. The peak of hyperbilirubinemia due to direct this disease occurs in the age group fraction, hypocoagulation – from 20 to 49 years. It is known that prothrombin index 28%. Diagnosed about 30% of the population has as: acute viral hepatitis, fulminant already had the contact with people course. By the combination of clinical who were infected with the hepatitis and laboratory findings the patient B virus.The prevalence of hepatitis was transferred to the intensive care fluctuates from 0.1% to 20%. In this unit. In the dynamics 02.02.16 is case, for 1 incident of acute hepatitis observed the progression of hepatic B occurring with jaundice, can be to encephalopathy, consciousness at 10 anicteric forms, and in 0,1-0,5% the level of stupor – coma I degree, of incidents of acute HBV infection liver – 2 cm above the costal margin. occurs fulminante. Examined by concilium, the Aim. To analyze the clinical diagnosis: acute viral hepatitis B ( features of fulminant form of acute identified HBsAg, anti-HBcor IgM, hepatitis B on the example of a DNA of HBV with negative total anti clinical case. HDV, anti HEV), fulminant course, Materials and methods. hepatic encephalopathy II-III degree. Clinical observation of the patient H., Conducted therapy: Lamivudine, 25 years old, who was treated in corticosteroids, protease inhibitors, Kharkiv Regional Clinical Infectious lactulose, hemostatics, detoxification Diseases Hospital in January - therapy, Rifaximin. 04.02.16 February2016. progressive encephalopathy with the Results. The patient was accession of convulsive syndrome, brought in Kharkiv Regional Clinical increase of the hepatic-renal failure, Infectious Diseases Hospital by the fatal outcome. Pathological and brigade of emergency medical clinical diagnoses – comparison of services 31.01.16 on the 4th day of 1A. illness with a diagnosis ARVI. The Conclusions. Supersharp patient was hospitalizedin to the course of fulminant form of acute Kharkiv Regional Clinical Infectious hepatitis B has led to the adverse Diseases Hospital with a preliminary outcome, despite adequate diagnosis: Food toxicoinfection? diagnostic and therapeutic tactics in After examination in the department the hospital. Scarce and nonspecific 01.02.16 were complaints about a symptoms at the early stage of a sharp general weakness, flaccidity, disease before the onset of jaundice drowsiness, yellowness of skin and causes diagnostic difficulties. The sclera. The liver is on the level of 1.0 most effective method of preventing cm below the costal margin. hepatitis B is a specific vaccination.

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NEUROSCIENCES

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ISIC-2016 Abstract book Ali Harb PARKINSON’S DISEASE, AND ITS RELATION WITH THC (TETRAHYDROCANNABINOL) Research advisor: Riznychenko O.K., candidate of med. science, ass.prof. Department of Neurology Nº1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality: Parkinson's disease tetrahydrocannabinol on Parkinson's (PD) is a degenerative disorder of disease and its symptoms. the central nervous system mainly Matherials and methods: 6 affecting the motor neuron, it is patients with Parkinson's disease primarily associated with the were asked to stop taking their usual gradual loss of cells in the substantia Parkinson's disease drugs, and they nigra of the brain which will lead to started to take only decrease in dopamine production, tetrahydrocannabinol in the morning and the presence of Lewy bodies and time, which was introduced Lewy neuritis(abnormal aggregates intravenously after breakfast. of protein that develop inside nerve Results: The study elicited cells in Parkinson's disease). This significant decreasing in tremor, will lead to tremor, bradykinesia, sleep disturbance, bradykinesia and soft voice, decreased in facial rigidity of limbs in 5 patients, and expression, sleep disturbance, barely decreased in one patient. decreased olfactory sensation, Conclusions: Based on the slowliness of thinking, malaise, obtained results, it can be stated that weakness, rigidity of limbs, dystonia. tetrahydrocannabinol helps relieve Inhibition of gamma-aminobutyric major symptoms of Parkinson acid action may lead to increasing in disease, and this effect is by dopamine levels; studies showed increasing dopamine levels by that tetrahydrocannabinol helps in blocking the action gamma- blocking gamma-aminobutyric acid. aminobutyric acid (GABA). The aim: The research aims at the study the effect of

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ISIC-2016 Abstract book Feldman D.A., Mykhaylov V.B. PSYCHO-EMOTIONAL DISORDERS IN DISPLACED RESIDENTS FROM ATO ZONE Research Advisor: DMSc., Prof., Academic of Academy of Sciences of highest Education of Ukraine, doctor of higher category Kogyna A.M. Department of Psychiatry, Narcology and Medical Psychology Kharkiv National Medical Iniversity Kharkiv, Ukraine

Actuality: As far as is known Results of the psycho-diagnostic the spectrum of potential mental investigations showed up that in disorders connected with their men the indices of a reactive alarm experience of life-threatening (average score – 37.7 ± 3.0) were situations is rather big. For higher than the indices of a trait rendering of psychological and anxiety (average score – 32.6 ± 2.9). psychiatrical help to people and In women the indices of a trait displaced residents from ATO (anti- anxiety (average score – 38.6 ± 2.9) terrorist operation) zone an were higher than the indices of a important thing is knowledge about reactive alarm (average score – 34.7 consequences of armed hostilities on ± 3.0). An average score on the the state of mental health that is an Hamilton Anxiety Rating Scale in actuality of this investigation. men: 17.0 ± 2.3 points, in women: The aim: To study 18.0 ± 2.3 points.On the life quality developmental peculiarities of scale, investigation of the individuals psycho-emotional disorders in did not reveal any substantial individuals of the displaced residents differences among men and women. from ATO zone. In the lowest level the scales were Matherials and evaluated as follows: methods: With the help of clinical ‘Psychoemotional State’, and psycho-diagnostic (Hamilton ‘Interpersonal Interaction’ and Depression Rating Scale, State-Trait ‘Overall Comprehension of the Life Anxiety Inventory, life quality scale) Quality’. Also, under the terms of the methods, 30 persons (15 men and 15 informed consent of the parents, we women) were investigated. conducted a survey of 10 refugee Results: Principal patho- children under the age of 9 years, psychological syndromes diagnosed who, together with his parents in the persons of displaced residents moved to Kharkov from ATO zone. from ATO zone: astheno-depressive There have been several major (75.9 %), astheno-distressing (82.5 clinical and psychopathological %), astheno-phobic (13.2 %), symptom: a dominance asthenia astheno-hypochondriacal (3.3%). (54%); anxiety and phobic

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ISIC-2016 Abstract book symptoms (26%); behavioral psychoemotional disorders of disorders (20%). various expression grades which Conclusions: Therefore in the need further correction in conditions majority of people having left ATO of specialized medical institutions. zone one can observe

Ghazal Bilal Hassan EFFECT OF POST-ISOMETRIC THERAPY ON PATIENT WITH TENSION HEADACHE Research advisor: As.prof. Riznychenko Olena Kharkiv National Medical University Department of neurology №1 Kharkiv, Ukraine

Actuality: Tension headache is of tension headache, for one month. the most common type of headache. PIR technique is based on loosening Tension produce pain in the neck up and activated the tensed muscles and shoulder resulting in (muscles of head and neck facial constriction of the blood vessels and muscles SCM muscle), begins by blood circulation resulting in placing the muscle in stretch position headache. Stress guilt fear and anger, then an isometric contraction is depression, and rage are all exerted against a minimal resistance, contibuting factors of tension a gentle stretch follow as muscle headache. Beside pharmacological release. All the patients were taught treatment, another techniques can be to do the same exercises in the same applied, post isometric relaxation range. (PIR), which is a massage therapy Results: 8 participants applied directed toward the exact points and the exercises on daily basis in which tension in particular muscles. seven of them declared a decrease in The aim: Prove the effect of frequency of tension headaches post-isometric relaxation therapy in attacks after three weeks, nine relieving of tension headache in patients said they had an instant young people. relief of pain when exerting the Materials and methods: ten exercises at the moment of attack. participants (6 females, 4 males) Conclusions: PIR is very were taught the method of PIR by a beneficial technique, which can be special therapist, and asked to apply easily done at home or under the it daily and at the moment of attack supervision of therapist, 144

ISIC-2016 Abstract book recommended to more studies (on and to be included in the basic of other muscles and other problems) treatment of tension headache.

Hleizer A. IMPACT OF GILLES DE LA TOURETTE SYNDROME ON THE INTELLECTUAL LEVEL OF THE CHILDREN Research advisor: Riznychenko E., candidate of medical sciences, associate professor Department of neurology №1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality: Gilles de la Tourette Matherials and methods:The syndrome is widespread disease, but research involved 6 children, aged 7 at the same time, one of the least – 11 with diagnosed Tourette studied disorder of central nervous syndrome. Children have multiply system. It’s characterized by motor, tics with different characteristics and phonic and behavioral tics. It was localizations. For evaluation was determined that high percentage of used Raven's Progressive Matrices in people suffering from Tourette accordance with the age of each syndrome also has learning child. difficulties and disruptions of the Results: The results obtained attention. One of the frequent that 4 children has average complains is the emergence of intelligence in their age group. Also 2 obsessive thoughts and actions. Since children have average intelligence, that disorder has significant impact but their results of test are on the on development of children and a low end of normal. frequency of detection of disease is Conclusions: Thus this study rising, we should pay particular shows that Tourette syndrome has attention on studying of Gilles de la little impact on the intellectual level Tourette syndrome from the of the children. However, we need to perspective of intellectual disorders. draw the attention to groups at risk The aim: To determine the to stop the deterioration of situation. extent of impact of Gilles de la And also we need to exclude the Tourette syndrome on the impact of other endogenous and intellectual level of the children. exogenous factors on the results of research.

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ISIC-2016 Abstract book Kashyrina O., Riznychenko O. EFFECTIVENESS OF ZINC PREPARATIONS IN TREATMENT OF HEPATOLENTICULAR DEGENERATION Kharkiv national medical university (neurology department №1), Kharkiv, Ukraine

Actuality: Hepatolenticular shaking form, 3 have shaking form degeneration, or Wilson’s disease is a and 1 patient has hyperkinetic form. severe chronical progressive disease, All patients got zinc preparations which is connected with genetically monotherapy for more than a year, determinate disorder of copper because of complications, caused by metabolism. On the average, there Penicillamine. are 30 cases in 1 million people Results: As a result of recorded in the world. And without treatment, we could observe treatment it can lead to death. improvement of neurological status Penicillamine is the first treatment in all patients. Namely, tremor used, often give complications. So decreased, dysphagia disappeared, there is a reason to search for new, increased speech, amplitude and more effectiveness and less toxic frequency of hyperkinesia also preparations for treatment of this decreased. Side effects, like minor disease. dyspepsia disturbed only 2 patients. The aim: To research Conclusions: Zinc effectiveness of zinc preparations in preparations are effective in treatment of hepatolenticular treatment of hepatolenticular degeneration. degeneration and can be a good Matherials and alternative to penicillamine. Zinc methods: There are 8 patients (5 preparations have low toxicity and females and 3 males) with diagnosis they don’t cause serious hepatolenticular degeneration under complications. However, according observation. The age at the moment to clinical forms and diagnostic of hospitalization is from 16 to 34 methods, along with pathogenetic years, on the average 24,7 years. At therapy, patients also need to get the moment of disease debut – from symptomatic therapy 1-2 times per 12 to 23 years old, on the average year. 17,9 years old. 4 patients have rigid-

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ISIC-2016 Abstract book Kennedy Enem TRIGGERS OF MIGRAINE IN DIFFERENT PATIENTS AND CONDITIONS Research advisor: Riznychenko O.K., Candidate of medical science associated professor Department of neurology No 1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality: migraine is a primary Results: The patients each headache disorder characterized by mentioned their own individual recurrent headaches that are peculiarity to the triggers, that is moderate to severe. Typically, the each patient noted that they headaches affect one half of the head responded to some triggers but are pulsating and last from 2 to 72 didn’t have any effect from some hours and many patients get other ones and that they discovered reocurruring migraines without new triggers to their migraines from being sure of their triggers and so the experiment which they didn’t are left clueless on how to avoid know about earlier migraines. Conclusions: Doctors should be The aim: To prove that able to fully understand that different people have very patient’s triggers are very different completely different triggers for and varied and that many times the migraine. patients are not fully aware of all Matherials and methods: Ten their triggers and as such should do participants (5 females and 5 males) proper observation, anamnesis were asked about the causes of their verification and experimentation migraine and then we tested them before concluding, so that they can separately with triggers of all the properly advice their patients on patients including ones we suggested trigger avoidance mechanisms. ourselves for 3 days.

Korolkova A. THE PROBLEM OF EARLY DIAGNOSTICS OF FRIEDREICH'S ATAXIA Research advisor: Teslenko O. Department of Neurology, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality: Friedreich's ataxia progressive damage to the nervous (FA) is an autosomal recessive system because of particular genetic inherited disease that causes mutation in the FXN gene. This one

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ISIC-2016 Abstract book encodes the protein frataxin. The most exact test is the DNA- Frataxin is very important for testing. This method can find the mitochondrial work, it takes the iron damaged gen and differ this ataxia out of mitochondrial area. If there is from another one. It is also not enough frataxin, the excess of important to perform iron induces producing of dangerous Electrocardiography (indicating free radicals. The condition is called Cardiomyopathy), after German physician Nikolaus Electromyography, X-ray Friedreich, who was first to describe radiography (indicating bones it in the 1860s. This pathology is one pathology) and blood test (for of the first inherited ataxia which endocrine disorder). The advantage was found out in a big group of of DNA-testing is the ability to make locomotor diseases. Its incidence in this research at any age and get the general population is roughly 1 authentic results. in 50,000. FA has clear diagnostic Results: This work shows us signs. availability of methods enough for The aim: to analyze the existing diagnostics in this group of patients. methods of diagnostics of Early detection of the problem is Friedreich's ataxia, to pay attention possible and necessary for treatment of medical community to the assignment in right period. It can significance of early detection of this improve the quality of a patient`s life. pathology. Conclusions: It is necessary to Materials and methods: Some pay doctor`s attention to the literature sources were analyzed in existence of such problem. This order to get the information about problem is relevant especially for this problem. It was revealed that the pediatricians, cardiologists, disease has typical clinical endocrinologists and orthopedists- indications: autosomal recessive traumatologists because of the inherited disease; start under 25 different signs of this pathology. Also years old, progressing of ataxia, it is real to diagnose FA and help muscle weakness in arms and legs, patients by sending them to genetics weakness of tendon reflexes, loss of and neuropathologists. vibratory and proprioceptive sensation, dysarthria.

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ISIC-2016 Abstract book Kraskovska Т. PSYCHOEDUCATION AS ONE OF THE COMPONENTS OF RESOCIALIZATION IN PATIENTS WITH DEPRESSION Research Advisor: PhD. Zelenska K. Department of psychiatry, narcology and medical psychology, Kharkiv national medical University, Kharkiv, Ukraine

Actuality: Depression is a included pharmacotherapy and mental affective disorder, which is psychoeducational classes in groups manifested by the triad: slowing of of 6-7 patients. The cycle consisted of thought and speech, low mood and 10-12 classes: 1.5-2 hours 1-2 times loss of ability to rejoice, retardation a week. of motor skills. International Methods: clinical- epidemiological research has shown psychopathological: the study of that the frequency of depression in complaints, mental and somato- society varies from 4.8 to 7.4 %. 25 neurological status, the allocation of % of patients of General the main psychopathological practitioners had depression. syndromes; psychodiagnostic using Depression is one of the main scales of anxiety and depression of motives of suicide in all countries. Hamilton (M. Hamilton, 1967), Every year depressed patients hospital scale of anxiety and commit suicide 850 thousand times. depression (HADS), (Zigmond A. S., WHO reports that half of the patients Snaith R. P., 1983);statistical. with depression are not receiving the Results: In patients received necessary support due to incorrect proposed therapy rapid reduction of diagnosis of the disease or due to the psychopathological symptoms, fact that do not seek the help of normalization of emotional state, doctors. stabilization of behavior, The aim of our research was improvement of cognitive functions, to study the complex system of increasing of psycho-physical psуhopatology in patients with activity of patients, expansion of depression as a part of psychosocial contacts with others, the resumption rehabilitation and the development of the usual mode were noted. By the of optimal methods of application of fourth week of the therapy the psychoeducational programs in indicators on a scale of anxiety and complex rehabilitation of patients depression Hamilton from 26 points with depression. decreased to 10.5 points; on hospital Materials: we examined 20 scale of anxiety and depression from patients of both sexes aged 18-45 11 points to 6. years with depression according to Conclusions: an integrated the ICD-10 criteria, complex therapy approach in the treatment of

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ISIC-2016 Abstract book depression including psychoeducational training leads to pharmacotherapy using inhibitors of restoration of social activity and reverse capture of serotonin and successful resocialization of the norepinephrine in combination with patients.

EFFECTS OF PLASMAPHERESIS AND PHYSICAL EXERCISE ON A PATIENT WITH MULTIPLE SCLEROSIS. Majida Sameja and Komal partap singh Research advisor: candidate of medical science associated professor Riznychenko O.K. Kharkiv national medical university Department of neurology no 1, Ukraine, Kharkiv

Actuality: Multiple sclerosis is exchange to manage sudden, severe characterized by disseminated attacks, sometimes called relapses or patches of demyelination in the brain flare-ups. Their plasma could have and spinalcord.common symptoms certain proteins that are attacking include visual and oculomotor their own body. When you take out abnormalities,paresthesias,weakness the plasma, you get rid of those ,spasticity,urinary dysfunction and proteins, and symptoms may get mild cognitive better. impairment.Typically,neurologic Results: The process isn't deficit are multiple,with remissions painful, and does not need and exacerbations gradually anesthesia.You'll lay in bed or sit in a producing disability. reclining chairt a needle attached to Diagnosis, requires clinical or MRI a thin tube, called a catheter, into a evidence of >/= 2 characteristic vein in each arm, you may have to neurologic lesions that are separated have a needle in the patients in both time and space (location in shoulder; blood comes out through the CNS). one of the tubes and goes into a The aim: prove the effect of machine that separates your plasma plasmaphoresis and physical from your blood cells. Then your exercise in relieving of Multiple blood cells get mixed with fresh sclerosis. plasma, and the new blood mixture Matherials and methods: 8 goes back into your body through the participants (5females,3males) was other tube.patient were advised to done and exercising not less workout 30minutes daily. than30minutes daily and The 8 patients where administered plasmapheresis ounce a with daily exercises and they month,plasmapheresis is by plasma declaired that there symptoms had 150

ISIC-2016 Abstract book reduced including tremor , muscle Conclusions: it was observed pain , weakness. that plasmapheresis was beneficial against multiple sclerosis.

Obi Chioma Annastasia ROLE OF AGE AND SEX DIFFERENCE IN ATHLETES WITH CONCUSSION Research advisor: Kufterina Nataliya, Dr Department of neurology Kharkiv national medical university, Kharkiv, Ukraine

Actuality: Concussion is as a Concussion Symptom Scale (PCSS) at result head injury which occurs baseline and again at 2, 7, and 14 without signs of neurological deficit. days after concussion. Participants Currently, researchers have begun to completed the Balance Error Scoring focus on age and sex differences in System (BESS) at 1, 2, and 3 days concussion outcomes. The results after concussion. shows that younger athletes and Results: Female athletes female athletes may take a longer performed worse than male athletes period of time to recover from a on visual memory (mean, 65.1% and concussion. Moreover, much is not 70.1%, respectively; P = .049) and yet known about the interactive reported more symptoms (mean, effects of age and sex on symptoms, 14.4 and 10.1, respectively) after neurocognitive testing (NCT) and concussion (P = .035). High school postural stability. athletes performed worse than The aim: The aim is to college athletes on verbal (mean, determine the symptoms in various 78.8% and 82.7%, respectively; P = sex and age, NCT, and postural .001) and visual (mean, 65.8% and stability following concussion. We 69.4%, respectively; P = .01) have observed that high school and memory. High school athletes were female athletes would have worse still impaired on verbal memory 7 symptoms, NCT, and postural days after concussion compared with stability than college and male college athletes (P = .001). High athletes, respectively. school male athletes scored worse on Materials and Methods: A the BESS than college male athletes total of 296 concussed athletes from (mean, 18.8 and 13.0, respectively; P a multistate, 2-year study were = .001). College female athletes enrolled in this study. Participants scored worse on the BESS than high completed the Immediate Post- school female athletes (mean, 21.1 Concussion Assessment and and 16.9, respectively; P = .001). Cognitive Test (ImPACT) and Post- 151

ISIC-2016 Abstract book Conclusions: The results of interpreting symptoms, specific the current study supported age and components of NCT, and postural sex differences in memory and stability tests. Future research symptoms and an interaction should develop and assess between age and sex on postural interventions tailored to age and sex stability after concussion that differences and include younger warrant consideration from (<14 years) participants. clinicians and researchers when

Olaniyan Mercy THE USE OF MUSIC THERAPY IN THE TREATMENT OF ANXIETY AND DEPRESSIVE DISORDERS IN PREGNANT WOMEN Research advisor: Leshchyna Iryna MD, Candidate of medical sciences(PhD) Kharkiv National Medical University Psychiatry, narcology and medical psychology

Actuality: Currently, most Material and methods: scientists hold the view that women Clinical-psychopathological, during pregnancy are at increased psychodiagnostical (Hamilton risk of developing mental Depression and Anxiety Scale, disturbances, and the most «Quality of life index») and methods commonly found are anxiety and of statistical analysis were used. In depressive disorder due to hormone the research, 25 pregnant women changes that affect the chemicals in were inspected aged between 20 and the brain. 32 years. Gestational age ranged The limited use of pharmacological from 22 to 32 weeks. treatments for affective disorders in Results: In 56% of the women during gestation determines examined women were observed the need to consider psychotherapy affective disorders of mild and as the main method among which moderate severity in the form of the least studied is the therapeutic depressed mood, anxiety, fear, effect of music. irritability, decreased mental and The aim: The purpose of our physical activity. According to the study is to evaluate the effectiveness Hamilton scale, anxiety disorders of music therapy in the treatment of were diagnosed in 44.0% of anxiety and depressive disorders in pregnant women. Most of them pregnant women. (63.6%) were characterized by mild degree of anxiety, 36.4% - moderate 152

ISIC-2016 Abstract book and severe. In 24.0% of women of pregnant women in the first group depressive disorders of mild and was noted normalization of anxiety moderate degree were identified. In and depression. In 21.42% cases the analysis of the profile of the affective disturbances decreased to quality of life, the following attract subclinical stage. In 7.14% of women attention: the significant decline of - positive dynamics, but indicators indicators on the scale of remained at high level. The profile of «Interpersonal interaction» (5.35± the quality of life was characterized 0.55), «Psychological and emotional by greater uniformity of assessments well-being» (5.45±0.2), «Physical of different aspects of life. The study health» (6.05±0.25). identified significantly larger In order to determine the efficacy of increases in these indicators in the music therapy in treatment of main group than the control emotional disorders in pregnant, 2 (p<0.01). groups were allocated: the first - Conclusions: The use of music consisted of 8 patients, who received therapy in complex treatment of complex treatment with music anxiety and depressive disorders in therapy, second group – women, who pregnant women is an effective were treated with standard therapy psychotherapeutic tool aimed to (6 people). Music - therapy sessions normalize the emotional and were conducted in groups of 8 psychological state of women, people lasting 60 minutes with a improving their adaptive capacity, frequency of 3 times per week for 2 quality of life and it plays an months. important role in preparing for As a result of complex therapy with successful delivery. the use of music therapy, in 71.44%

Olefir O.S. COMPUTER ADDICTION AS A FACTOR OF PROVOKE SITUATIONAL ANXIETY INCREASING Kharkiv National Medical University, Department of Psychiatry and Medical Psychology of Addiction Supervisor: Cherkasova O.

The term "computer addiction" concerned with mental disorders, defines a pathological addiction but the phenomenon of formation of person to work or spending time at pathological human-computer the computer. This term is still not communication was evident and recognized by many scientists becoming more razmah.Situativnaya 153

ISIC-2016 Abstract book anxiety as a condition characterized According to the research, the by subjectively experienced following conclusions: emotions: stress, anxiety, concern, 1. The presence of a human nervousness. This condition occurs computer addiction significantly as an emotional reaction to a increases the risk of increasing the stressful situation and may vary in level of situational anxiety, and thus intensity and dinamichnosti.Danaya leads to a decrease in its adaptive work is the second stage of the study, capabilities. in which we prove the hypothesis 2. preventive measures to prevent that lightning technology computer addiction in children and development and implementation of adolescents within the family and the them in our daily life has some school should be carried out. Parents negative mental health Aspects. and teachers help children learn the To confirm this idea, we real world. It is important that they investigated the relationship are also taught children "safety between the presence of computer rules" in the virtual world addiction and the level of situational 3. The basic principle of easing and anxiety in three age groups (Group 1 addiction treatment - replacement - Class 3 pupils, Group 2 - Class 8 of: the formation of a full spiritual students, 3 group - 3 rd year student and intellectual life, live of the Faculty II KhNMU.). For the communication with parents and study were used standard peers, attention and care, training on questionnaires Spielberger-Hanin clubs and sports clubs, help with the and the Russian-language adaptation work on the house. of the questionnaire Kimberly Young. 4. It is necessary to develop a culture As a result of the study, we of dialogue with the computer. It is have the following results were important to show the minor that found: in group №1 elevated levels using a computer is interesting to of situational anxiety was observed develop intellectually, to receive the in 5 children and computer addiction necessary and useful information, defined in 8, №2 in the group, these engage in learning, etc. figures were 12 and 8, and in the 5. The computer should be placed group №3 - 8 and 5 respectively. In where it is more convenient to favor of solvency extended contact control the use of minors as well as hypothesis is the fact that the mass to establish clear requirements for fraction of the studied children and the use of computers and the students with computer addiction Internet, and they always require among those who have been strict compliance. identified elevated levels of 6. In order to preserve the health of situational anxiety, Group №1,2,3 the younger generation must be was 100%. properly organize the workplace for the computer to constantly monitor 154

ISIC-2016 Abstract book the posture, and regularly take exercises. breaks to rest and do physical

Plyekhova O.O., KalyuzhkaV.Yu. THE LEVEL OF SOCIAL MALADJUSTMENT AND ANXIETY OF MODERN STUDENTS IN DEPENDING ON LOCATION OF LEARNING Research advisor: PhD Zelenska K. Kharkiv National Medical University, Kharkiv, Ukraine (Department of Psychiatry, Narcology and Medical Psychology)

Actuality: There is the highest Results: Only 10% of the risk of mental pathology students, which were surveyed, are manifestation in connection with a practically healthy.The rest of high level of load and stress in the students have chronic diseases.Only student's age, which are important 8% of the students had a chronic factors of emotional maladjustment. pathology at the time of admission to The aim: To determine the the University. The level of anxiety is level of students' mental health, to generally mediumin all groups, what evaluate the level of anxiety and reflects the effects on different stress maladjustment, to compare the level factors. During the session, and of maladjustment in students of before STEP-1 the level of anxiety is Kharkiv National Medical University sharply higher (3rd year of KhNMU). (KhNMU) and Kharkiv National A high level of anxiety have 42% of Automobile and Highway University students, that indicatesthe emotional (KhNAHU). and behavioral symptoms of chronic Matherials and methods: 120 stress. For 56% of first-year students healthy students of KhNMU (40 is typical a medium level of students from 1st, 3rd and 4th maladjustment, which requires the courses) and 80 students KhNAHU assistance of specialists in carrying (40 students from 1st and 3rd out rehabilitation. During training courses); the questionnaires, which for STEP-1decreases the quantity of consisted of three questionnaires: students with a satisfactory general questions, the questionnaire adaptation. We can observe it in a "Evaluation of occupational low professional adaptation of maladjustment" and the Hospital students (62,5%)of the 3rd year of Anxiety and Depression Scale. All KhNMU. For the 4th year students a students were divided into five low level of maladjustment (80%) is groups: Group 1 – 1st year KhNMU, 2 typical. It is also note worthy that in – 3rd year, 3 – 4th year, 4 – 1st year none group of students KhNMU do KhNAHU, 5 – 3rd year. not decrease the level of anxiety

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ISIC-2016 Abstract book below 50%. In KhNAHU is the figure students 3 and 5 groups is low, but it 32%. is advisable to make an advisory The students whose parents are work of specialists. doctors, have significantly lower Conclusions: We can conclude level of maladjustment and anxiety that students are very contemptuous than the others. of their mental health, because less So, the level of professional than 20% can be called «healthy». maladjustment of students of the 1,2 While the level of anxiety, depression and 4 groups are fairly moderate, and maladjustment is in the range what requires the assistance of that can be corrected, students need experts to conduct rehabilitation. to take care of their health and The level of maladjustment of future.

Polikov G. QUALITY OF LIFE OF PATIENTS WITH NEUROSURGICAL DISEASES Research advisor: Zelenska C., PhD Department of Psychiatry, Narcology and Medical Psychology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: The result of the rating scale integrated indicator of treatment process can be estimated quality of life (Mezzich I., Cohen N., taking into account a number of Ruiperez M., Lin I., and Yoon G., indicators. These include: life 1999). expectancy, quality of life, total and Results: Created 2 groups. The postoperative mortality. Quality of first (I) group consisted of 9 patients life is an integral characteristic of the with severe restrictions on physical, mental, emotional and movement. This group included social functioning of a person. patients diagnosed with: Acute The aim is to evaluate the ischemic attack (7 persons); quality of life in patients with Meningioma (2 people). The second neurosurgical pathology, after the (II) group consisted of 8 patients treatment process. with no traffic restrictions. In the II Materials and methods: We group included patients with conducted a comprehensive survey diagnoses: Closed head injury (2 of 17 patients aged 28 to 60 years persons); Acute ischemic attack (3 old of both sexes who are in persons); neurosurgical hospital in the Osteochondrosis(3people).In the I postoperative period. Quality of life group, the mean score of quality of assessment was performed using a life 5.6. According to obtained values 156

ISIC-2016 Abstract book subscales: subjective well-being and and mental well-being, self-service satisfaction - 5.3 points; fulfillment of and the independence of action, social roles - 5,2 points; the external health, personal realization. conditions of life - 6.7 points. In Conclusions: It is very group II, the average quality of life important for patients with score was 7.8. According to obtained neurosurgical pathology, are in the values subscales: subjective well- postoperative period is the degree of being and satisfaction - 7.5 points; restrictions on movement and fulfillment of social roles - 7,8 points; deterioration of self-independence the external conditions of life - 7.6 activities, health, personal points. realization. In our view, it is Quality of life was significantly important counseling and provision reduced depending on the severity of of qualified psychological support for traffic restrictions regardless of the patients with different neurosurgical patient diagnosis. In this case, the I pathology in the pre- and group of patients come to the fore postoperative period. experiences regarding the physical

Praharaj Pooja, Nekrasova Nataliya SPONDYLOGENIC INFLUENCE ON VERTEBRAL ARTERIES IN VERTEBROBASILAR INSUFFICIENCY Research advisor: Nekrasova Nataliya MD,PHD Kharkiv National Medical University DEPARTMENT OF NEUROLOGY № 2

Actuality: Vertebrobasilar intervertebral space.Osteophytes insufficiency (VBI) describes located laterally and anterolaterally condition where there is an adjacent to vertebral artery play insufficient delivery of blood flow via major role in occlusion.These the vertebral or basilar arteries to patients are prone to ischemia and the brain. The etiology may be based stroke.The symptoms include: on the atherosclerosis, vertigo (dizziness),visual lipohyalinosis, vertebrobasilar artery disturbances(blurring, graying, dissection or embolic occlusion or by double vision), drop attack (sudden cervical osteophytes.When vertebral falls),numbness,tingling and slurred compression results from or lost speech. osteophytes,it leads to a condition The aim: to assess called as osteochondrosis which is spondylogenic influence on vertebral defined as narrowing of 157

ISIC-2016 Abstract book arteries during rotational probes in blood in posterior cerebral artery patients with SVBI. (PCA) by 32.9%, in vertebral artery Materials and methods: We (VA) by 23.1%, in basilar artery (BA) examined 98 patients (women - 56, by 23.4% compared to men - 42) with manifestations of corresponding parameters in control SVBI on the background of group were revealed. Also signs of neurovascular and radicular vascular tone increase in the syndromes of cervical vertebobasilar system according to osteochondrosis of a vertebral level of index pulsatility (PL) and column. Patients from 18 to 40 years resistance index (RL) on an average (median age of 28.5±3.8 years) were of 3.1 and 1.8 times were included in this study. All study detected.The change in linear subjects underwent functional X-ray velocity on the degree of head examination of cervical vertebral rotation was significantly higher in column with bending and extension, patients with VBI. The group of cervical spine MRI. Patients patients had variations in the underwent an ultrasonic number of Vr changing cases by 30 dopplerography and transcranial % and more (Р < 0.05).The dopplerography of cerebral vessels significant differences were with functional loading tests (head established during functional loading rotations. We studied the dynamics tests (head rotations) by defined of blood flow indices in suboccipital reactivity ratio on rotational probe (VA3) segments of vertebral and (RR). It was established that the RR basilar arteries (BA) on head for BA in patients with SVBN was rotation in our patients. Velocity was raised comparing to control estimated initially in the patients’ (31.0±12.2 % vs. 6.5±2.5 %) prone position with the head’s (p≤0.05), the same direction was neutral position, then on maximum detected while analyzing RR for VA rightwards rotation, and after that (23.4±8.2 % vs. 5.1±2.2 %) (p≤0.05). on maximum leftwards rotation. Conclusions: Obtained Results: On the base of hemodynamic changes confirmed obtained data according to Doppler spondylogenic influence on vertebral research, reduction of velocity of arteries in patients with SVBI.

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ISIC-2016 Abstract book Tikhonova Olga, Kopytko Marina IMPROVING THE QUALITY OF LIFE IN PATIENTS WITH COMBINED CRANIO- MAXILLO-FACIAL TRAUMA Research advisor: Grygorova Irina, professor Department of neurology Kharkiv national medical university, Kharkiv, Ukraine

Actuality: The incidence of with combined cranio-maxillo-brain traumatic brain injury annually in injury -dysphagia, and in this case, Ukraine is in average 400-420 per the non-steroidal antiinflammatory 100 000. Currently acquired drugs intake is difficult. In this relevance the study of military situation medication used traumatic brain injury(TBI), much of "Movixicam", which, due to the form, which occurs in the form of dispersible in the oral cavity, prevent combined injury. pain in this group patients without The aim of this work is the discomfort if swallowed. examination of patients with Due to the direct and indirect combined cranio-maxillo-brain neuronal damage in TBI activates the injury, which were in Regional mechanisms of neuroplasticity that clinical hospital in neurological and leads to a qualitative and maxillofacial departments. quantitative restructuring of Results: In the acute phase of neuronal and glial elements. mild TBI in 98% showed signs of Pharmacological agents with asthenic syndrome, 94% - syndrome neurotrophic, neuroprotective and of vegetative dysfunction, 85% anti-apoptotic effect, such as liquor-hypertensive syndrome, 74% "Cerebrolysin", reduce the activation of the detected autonomic of microglia, releasing of dysfunction. In 60% of patients with proinflammatory cytokines and mild TBI in the acute period, there excitotoxins, which makes the was cephalgic syndrome. In addition mechanisms of neuroprotection and to clinical and neurological neuroplasticity more effective. examinations were conducted Conclusions: it is extremely neuropsychological tests such as the important to improve the quality of Montreal scale, Schulte table and 10 life of patients with combined words memorization test. The cranio-maxillo-brain injury: results of the tests showed mild adequate pain relief with form of cognitive impairment. intake, and correction of cognitive A frequent complaint in patients and neuroplastic violations.

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ISIC-2016 Abstract book Ulyanovskа M. ANALYSIS OF MEDICAL UNIVERSITY STUDENTS` COMPETENCY IN THE PROBLEM OF EPILEPSY Research advisor - Assoc. Prof. Maliarska N. V. Department of Neurology, Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine

Actuality: The epilepsy is a persons (67.27%) - “ No, I had never brain disease that is characterized by seen”, 19 (17.27%) – “Yes, I saw it persistent tendency to development once”, 7 (6.36%) – “Yes, I provided of epileptic attacks and help once”, “4 (3.64%) – “Yes, I saw neurobiological, cognitive, it several times”, 6 ( 5.45%) - "Yes, I psychological and social provided help several times”. The consequences of this condition. question "Can you provide the first There are 40-50 million registered aid for seizures?" 44 persons (40%) patients with epilepsy in the world, answered "Yes" and 66 persons according to the WHO. In Ukraine, (60%) - "Not sure". The question "In the number of registered patients your opinion, is an epilepsy an with epilepsy at the end of 2013 was incurable disease?" 48 (43.64%) 0.25% of the total population. responded "No" and 62 (56.36%) The aim: To investigate the "Yes." To the question "Do you agree competency of students in the that the epilepsy is a mental illness?" problem of epilepsy and to 60 (54.55%) responded "No" and 50 determine the feasibility of a round (45.45%) - "Yes". The question "Is it table discussion of this topic. true that persons suffering from Materials and methods: The epilepsy often die during seizures?" study was conducted by anonymous 58 (52.73%) responded "No" and 52 survey of students of the medical (47.27%) "Yes". 17 individuals university by means of a (15.45%) answered all four questionnaire containing 20 questions about the rules of first aid questions divided into blocks. correctly. 101 person (91.82%) Results: The survey involved answered the question "Do you want 110 respondents - students of 1-6 to learn more about epilepsy?" courses of higher medical schools of “Yes”. Ukraine (Lviv National Medical Conclusions: Two thirds of University preferably), including 75 interviewed people have never seen (68.18%) women and 35 (31.81%) seizure attack. About half of the men. The question "Did you ever respondents made mistakes, observe or even provide medical answering important questions care during an epileptic seizure?" about epilepsy. 40% of respondents respondents answered as follows: 74 claimed that they know how to help

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ISIC-2016 Abstract book a person with seizures and only table devoted to the problem of 15.45% were able to answer all epilepsy in the university, paying questions concerning the rules for attention to the issue of first aid for providing such help correctly. About seizures, to debunk some common 92% of respondents would like to myths concerning this disease and to learn more about epilepsy. demonstrate some videos which can Therefore, we consider it illustrate different types of attacks. appropriate to organize the round

Zahora O. INFLUENCE OF CENTRALLY ACTING MUSCLE RELAXANTS TO THE MUSCLE SPASM IN POST-STROKE PERIOD Research Advisor: Candidate of Medical Sciences, Associate Professor Riznychenko O. Department of Neurology № 1, Kharkiv National Medical Iniversity Kharkiv, Ukraine

Actuality: According to World the initial dosage of 50 mg two times Health Organization data, one of the a day for reducing muscle tone was main causes of disability is a stroke. used for 4 patients. Another half of Persistent motor dysfunction after patients (4) as a muscle relaxant the disease significantly reduces the drug was assigned the preparation quality of patients life, so the with the active ingredient tizanidine complex therapy initiated as early as in a dosage of 2 mg three times a day. possible helps for early recovery of Both groups received drugs for 2 patients. weeks. The aim: to compare the effect Results: In all cases positive of central muscle relaxants to the dynamics was noted as decrease of occurrence of undesirable muscle muscular spasticity. The group of weakness. patients who accepted pills with the Material and methods: the active ingredient tolperisone also study included 8 patients aged 55-63 noted an expressed general muscle years who had a history of ischemic weakness, which significantly stroke: 3 patients - in the left reduces the efficiency of restorative cerebral artery pool, 5 - in the right physiotherapy. cerebral artery pool. After 3 months Conclusions: The research has of combined therapy in post-stroke shown that in order to reduce muscle period muscle the relaxant drug with spasticity after stroke it is preferable the active substance tolperisone in to use drugs of tinazidin as they have 161

ISIC-2016 Abstract book a good muscle relax effect and do not contrast to tolperisone. cause undesired muscle weakness in

Zelenska K.O. ANALYSIS OF STRESSFUL SITUATIONS THAT LEAD TO DEVELOPMENT OF AUTO-AGGRESSIVE BEHAVIOR IN PATIENTS WITH DEPRESSIVE DISORDERS Research advisor – Professor Kozhina H.M. Department of Psychiatry, Narcology and Medical psychology, Kharkiv National Medical University, Kharkiv, Ukraine Actuality: Suicidal behavior is Hamilton Depression (M. Hamilton, the most life-threatening form of 1967), adapted to the ICD-10 (GP auto-aggressive activity, since its aim Panteleyev 1988) (HDRS); Berg-scale and motive is action leading to a Montgomery (Montgomery SA, voluntary death. Suicide is an Asberg M., 1979), adapted to the ICD- extreme form of suicidal behavior, 10 (Guelfi GD, 1993) (MADRS); implying conscious voluntary actions method "of suicide risk determining" aimed intentional achieving of own (Gavenko VL, Sinayko VM, Sokolov death and leading to it. The constant IM, 2001); "Self-rating test of auto- increasing of the prevalence of aggressive predictor severity" autoagressive behavior, particullary (Pilyagina GY, 2004), statistical. in suicide cases and suicide attempts Results: thus, the analysis of among the population of Ukraine in the data allowed us to determine the recent decades poses suicidology in main stressful situations leading to some of the most important areas of the development of suicidal behavior research for the Ukrainian in young adults with depressive psychiatrists. disorders: the loneliness, the loss of a The aim: To identify the major beloved one, divorce (39.2% women stress events entailing suicidal and 34.3% men), serious financial behavior in young persons. difficulties, unexpected collapse of Materials and Methods: 96 property, loss of a job (49.2% patients of both sexes aged 18 - 35 women and 64.3% men), forced years with signs of suicidal behavior dramatic change of life stereotype were surveyed. The methods were (16.9% and 11.2%, respectively), used: clinical, psychopathological, family (58.3% and 64, 2%) and duty clinical-anamnestic, (5.9% and 5.6%) relation conflicts, psychodiagnostic using the hospital cruel treatment with persons who anxiety and depression scale (HADS) commited suiside (52.8% and 46.1%, (Zigmond A. S., Snaith R. P., 1983); respectively), the situations with Clinical Anxiety Scale and the long-term mental stress (12.3% of 162

ISIC-2016 Abstract book women and 7.9% men), poor of the cognitive content and physical health, the presence of dominance of mental trauma in the disabling disease (11.3% of women mind, the loss of life meaning. and 6.3% of men). Determening of a trigger mechanism Conclusions: The next of autoagressive behavior is one of stressful situations that lead to the main components in predicting suicidal behavior were identified: the the risk of suicide. frustration of basic needs, narrowing

Korovina L. D., Kondratenko A. P. THE COMPONENTS OF THE DYNAMICS OF BODY WEIGHT IN PATIENTS WITH PARANOID SCHIZOPHRENIA.

Schizophrenia - one of the The study showed that in the most severe mental illnesses. first year of therapy, the highest Significant advances in the treatment weight gain was while taking of this disease appeared with the amisulpride. Risperidone caused an discovery of neuroleptics average increase in weight in the (antipsychotic drugs). Initially, the first year, but it progressively practice of first-generation drugs increased throughout the time of have been introduced. But they not therapy and reached a level of only showed its activity towards the obesity. Quetiapine drugs cause symptoms. Antipsychotics caused weight gain a few kilograms per year, significant complications - with a mass of stabilization in the neuroleptic syndrome. second year of therapy. Pre-emptive use of atypical Change one antipsychotic antipsychotics based on their impact drug to another is not always result on the positive and negative in weight loss. When changing symptoms of schizophrenia, it is risperidone to quetiapine, weight extremely rare appearance of loss noted only in patients treated neuroleptic syndrome. At the same with antipsychotic in combination time, in recent years there are many with psychorehabilitation program. works devoted to another type of Thus, we think that an side-effects - neuroendocrine effects. increase in body weight in patients In our research we followed with paranoid schizophrenia is the impact of various second associated with prolonged use of generation antipsychotics on weight second-generation antipsychotics. gain of women with paranoid But the development of abdominal schizophrenia with complex obesity depends on a complex of treatment. factors, including the level of physical and social activity, the 163

ISIC-2016 Abstract book severity of the negative psychic the possibility of self-realization and symptoms (primary and secondary), the availability of support.

Hmain S., Kozhina H.M. INFLUENCE OF ART THERAPY IN COMPLEX TREATMENT ON THE QUALITY OF REMISSION IN PATIENTS WITH RECURRENT DEPRESSIVE DISORDER Department of Psychiatry, Narcology and Medical psychology, Kharkiv National Medical University, Kharkiv, Ukraine

Introduction. According to We used clinical, studies done in recent years psychopathological, regarding the treatment of patients psychodiagnostic and statistical with recurrent depressive disorder, a methods. shift of interest from studies Results. The results of the evaluating the effectiveness of effectiveness of art therapy in therapy to the study of remission is complex treatment in patients with seen. According to the literature, recurrent depressive disorder is complete remission occurs in only detected primarily in reducing of the 40-50% of patients, in other cases level of anxiety at the early stages of there is residual symptoms. treatment, as well as in reducing of Aim. Evaluating the the severity of anhedonia and effectivness of art therapy in improving the quality of life in treatment in patients with recurrent remission period. depressive disorder on the quality of Conclusion. These results remission. support the use of art therapy in Methods: The study involved treatment in patients with recurrent 135 patients – 60 –male and 75 depressive disorder during period of female patients aged from 18 to 30 active treatment, and after achieving years old. The main group of patients clinical remission contributes to apart the combined treatment also achieving and maintaining high- participated in group art therapy quality and stable remission with full with the use of drawing techniques, restoration of quality of life and while the control group – statutory social functioning. standard therapy.

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ISIC-2016 Abstract book

OBSTETRICS AND GYNECOLOGY

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ISIC-2016 Abstract book Alaya Lamia MOLECULAR BIOLOGICAL FACTORS OF GENITAL PROLAPSE IN PERIMENOPAUSAL WOMEN WITH CONNECTIVE TISSUE DYSPLASIA AND THEIR CORRECTION Research advisor:Prof. Scsherbina Mykola Kharkiv National Medical Iniversity Department of obstetrics and gynecology №1

Actuality: The genital elements involved in collagen prolapse, as part of the formation are also played an gynecological pathology, according important role in the collagen to different authors it is from 1.7 formation processes to 28%, particularly among The aim :The aim of the women older than 40 years this study was to investigate the figure rises to 34.7%. In 85.5% of molecular biological factors patients with genital prolapse the associated with the genital following symptoms occur: prolapse in menopausal women urinary incontinence in 70% of with connective tissue dysplasia. patients, defecation disorders in Materials and methods: 36.5% and dyspareunia in 53.3% We examined 65 women in patients.According to modern perimenopause with genital research, the leading cause of prolapse of 1-2 stages. The prolapse is the dyspalsia of the patients were divided into two systemic connective tissue groups according to age and the dysplasia (CTD), CTD is common presence of phenotypic signs of in 48% cases among women with CTD and the applied treatment. genital prolapse. CTD is a Clinical characteristics and the multisystemic pathology with a estradiol concentration of the progressive course, which is matrix metalloproteinase 9 (MMP- charcterised by the defects in the 9) activity in serum were protein synthesis or catabolic determined. mulfunction of the components of Results: Women in both the extracellular matrix of the groups with clinical signs of connective tissue. Matrix genital prolapse showed a metalloproteinases (MMPs) play a significant (p <0,05) decrease in critical role in regulating the the estradiol concentrations homeostasis of the extracellular compared to the physiological matrix. MMPs are proteolytic norm. Thus, in the group 1 of enzymes involved in the patients with CTD symptoms the degradation and remodeling of the average estradiol level was 0.13 ± connective tissue. Vitamins, trace 0.014 nmol/l and in group 2 it was

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ISIC-2016 Abstract book 0.27 ± 0.035 nmol / l. The elevated collagen destruction with the low levels of MMP-9 were detected in levels of estradiol. The data the group CTD symptoms obtained in this study allows us to (215,11±17,3ng/ml) compared to consider the MMP-9 activity the norm value determined among dysfunction and low level of women in perimenopause estrogens as the risk factors for (100,0±6,1ng/ml), which confirms this disease in perimenopausal pathogenic role of women. Promt response to the metalloproteinases in the hormonal disorders together with restructuring on the connective the metabolic therapy significantly tissue. increases the effect of preventative Conclusion: Patients with and therapeutic interventions for genital prolapse and connective genital prolapse. tissue dysplasia show increase

P. A. Alieva, S. E. Malikova, I.V.Zhuk IMPROVEMENT OF TREATMENT EFFICIENCY IN CHRONIC INFLAMMATORY DISEASES OF UTERINE ADNEXA Research advisor: Tuchkina I. Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical Iniversity Kharkiv, Ukraine

Actuality. Inflammatory inflammatory diseases of the pelvic diseases of the female reproductive organs (CIDPO) should actually be system prevail among gynecologic considered as polysystemic abnormalities and their frequency disorders involving complexes, comprises up to 70%. Chronic genital associated with many adaptation and extragenital conditions remain processes in the female body. most challenging in diagnosis and The aim of the study implied differentiation, as their treatment is examination of reproductive age associated with specific pathogenic patients, diagnosed with CIDPO, who mechanisms of their development. underwent in-patient treatment at The relevance of this problem is gynecological department of Kharkiv conditioned by a number of Maternity Hospital No.1 in the years significant long-term consequences 2014-2015. for women's health, such as Materials and methods. Main secondary infertility, menstrual clinical symptoms included pain disorders (MDs), ectopic pregnancy (65.6%), dysmenorrhea (51.1%), and pelvic pain syndrome. Chronic dyspareunia (27.9%), MDs as 167

ISIC-2016 Abstract book hyperpolymenorrhea (34.4%) and treatment results in a rapid and oligoopsomenorrhea (14.4%). significant reduction of pain Results. Bacteriologic findings syndrome, normalization of in patients with CIDPO revealed regulatory function of sympathetic- different types of coccobacillary adrenal system and MDs, microflora, chlamydia, ureaplasma, improvement of hemodynamic with the predominance of microbial parameters and elimination of associations in most cases. endothelial dysfunction, which Thiopoetin class of drugs (Glutoxim) substantially improves the results of was given priority in treatment and prevents relapses of immunocorrective therapy. the disease in future. Conclusion. Studies have shown that immunocorrective

Arsentyeva Alina CURRENT METHODS OF CERVICAL PREGNANCY DIAGNOSIS Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Cervical pregnancy Materials and methods: The (CP) is a rare form of ectopic study involved the assessment of pregnancy, which occurs at a medical histories of women with frequency of 0.1-0.4% cases. CP ectopic pregnancy who underwent development is conditioned by in-patient treatment at gynecological medical and surgical abortions, department of Kharkiv Maternity pelvic inflammatory diseases, uterine Hospital No.1 for the last 5 years. tumors and in vitro fertilization. CP Results: The assessment of is diagnosed when a trophoblast current methods of CP diagnosis attaches to the cervical canal below provided in the framework of the the internal os. The fertilized egg study showed that the diagnosis is grows into the muscle of the cervix based on clinical examination to form a single hypervasculated findings, human chorionic complex, due to lack of decidua in the gonadotropin (hCG) level in blood, cervical canal. Therefore, patients ultrasound (US), using color Doppler develop profuse bleeding in mapping (CDM) and magnetic disruption of the integrity of the resonance imaging (MRI). The study gestational sac. revealed that hCG level in blood does not correspond to CP gestational 168

ISIC-2016 Abstract book period. Increase in hCG tomograms (1 case) clearly identified concentration occurs slower than in the margins between the chorion and normal pregnancy. Ultrasound cervical stroma. Sagittal and examination with transabdominal transverse sections provided reliable and transvaginal probes determined visualization of the gestational sac the location and size of the uterus, and helped to detect its size. identified myometrium structure, the Conclusions: Thus, complex presence or absence of myomatous cases of differential diagnosis, nodules, endometriosis as well as especially in intact CP, traditional localization and size of the clinical methods and determination gestational sac. Ultrasound and CDM of hCG in blood should be of blood flow helped to visualize the accompanied by diagnostically location of chorionic vessels, crucial up-to-date examination evaluate vascularization of the techniques, such as ultrasound with uterus and its cervical division. MRI CDM and MRI of the pelvic organs.

Blagoveshchenskiy R., Reznik M. A., Rakityanskiy I. Yu., Rubinskaya A. N. HERPES VIRUS INFECTION INFLUENCE ON INTRAUTERINE STATE OF THE FETUS Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Intrauterine herpes during pregnancy. Numerous studies virus infections are among the most suggest the possibility of common infections. Numerous transplacental infection of fetus with studies have shown that by the age of herpes virus infections. 18 years more than 90% of the world The aim: To analyze the effect population gets infected with one or of herpes virus infections on the more of the currently known strains state of the fetus and course of labor. of herpes viruses. The presence of Materials and methods: The class Ig G maternal antibodies was course of pregnancy and delivery shown to have little effect on the was assessed in 20 women with developing fetus. Infected mothers herpes virus infection who more frequently give birth to a underwent follow-up treatment at healthy child while the greatest Kharkiv Maternity Hospital No.1. The threat in terms of perinatal loss is study also involved determination of presented by a primary infection the functional state of fetoplacental 169

ISIC-2016 Abstract book complex and the course of labor. Biophysical profile of fetus according These pregnant women were found to Vintzeleos et al. was estimated at to have Ig M, A to herpes virus 6-7 points in 16% and 5 points or infections. Somatic, obstetric and below in 4% of pregnant women. gynecological status was assessed in Disruption of fetoplacental blood all the patients by conventional flow at compensatory stage was methods of examination. The detected in 37.4% of pregnant condition of the fetus and changes in women, in 10.7% at the placenta were mainly identified subcompensatory stage and in 3% at by biometrics of the fetus, thickness decompensatory stage. and structure of the placenta, the Decompensated disruption of quantity of amniotic fluid and fetoplacental blood flow was the cardiotocography. Blood flow in indication for operative delivery. vessels of mother-placenta-fetus Cesarean section was performed in 7 system was determined by Doppler (35%) of the examined pregnant study. women. Delivery in the remaining Results: The study showed patients was characterized by that intrauterine growth retardation premature discharge of amniotic was diagnosed in 15% of pregnant fluid in 25%, meconium-tinged women. Signs of intrauterine viral amniotic fluid in 10% and uterine infection included oligohydramnios inertia in 22%. in 58% and placental hypoplasia in Conclusions: Thus, it can be 46% of cases. Cardiotocography concluded that herpes virus demonstrated episodes of infections adversely affect the deceleration, reduction in frequency condition of the fetus and disrupt and amplitude of oscillation, normal course of delivery. indicating chronic fetal hypoxia.

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ISIC-2016 Abstract book Borodai I., Molchaniuk D., Ponomarenko T. VIRUS AGENTS AS FACTORS OF HABITUAL MISCARRIAGE Research advisor: Lypko O., Doctor of Medicine, professor Department of obstetrics and gynecology №1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. Almost there are no Results. In our research we women with habitual miscarriage identified that virus Coxcackie A who haven`t any virus persistence. In have 95% of patients (16% in big amount of cases these women control group), Coxsackie B – 73% have a combination of different (in control – 8%), cytomegalovirus – viruses. It`s connected with the 61% (in control – 26%), herpes peculiarities of the patient's immune simplex – 55,5% (in control – 25%). system. And generally these patients Enteroviruses in acute disease in haven`t evident clinical early pregnancy cause the death of manifestations. Here we have a the embryo or fetus, the spontaneous vicious circle: the immune system miscarriage, prematurity. The leads to the persistence of viruses relationship of enteroviruses with and these viruses lead to the the development of autoimmune activation of bacterial flora, to the diseases is proved: circulating appearance of autoimmune immune complexes, their long disorders, which are the causes of presence in the bloodstream, cause abortion. So the timely diagnostics changes in the blood vessels, and treatment of the most common including placenta. Practically all virus infections is important for patients with cytomegalovirus had women with habitual miscarriage. disturbances in reproductive system: The aim was to determine the defective luteal phase because of most common virus agents, which hypofunction and hyperandrogens, persist in women with habitual chronic inflammatory diseases of miscarriage, and their role in genitals, different defects of uterine investigated pathology. development, cervical incompetence, Material and methods. We autoimmune disorders. Herpes studied 35 cases of women with simplex virus is the factor of habitual miscarriage. These women vulvovaginitises, chronic were examined for persistence of endometritis, cervical erosions. herpes viruses (herpes simplex virus, Conclusions. Thus, almost all cytomegalovirus) and enteroviruses women with habitual miscarriage (Coxsackie A, B). The control group have different virus agents and even consists of women with normal the combination of viruses. It can be pregnancy. the factors of miscarriage so the

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ISIC-2016 Abstract book timely diagnostics and treatment of important these infectious diseases is certainly .

Cherniakova A.E., Karmazina I.S. ROLE OF CERVICAL CANAL SCREENING IN DIAGNOSTICS AND THERAPY OF CERVIX UTERI PATHOLOGY Research supervisor: Shedrov A.A., associate professor, Candidate of Medical Sciences Department of obstetrics and gynecology №1 Kharkiv National Medical University Kharkov, Ukraine

Actuality: Cervix uteri is included visual and colposcopy unique organ which possesses examinations, cytological appointed functional independence examination of vaginal smears, and and supplies control of biological identification of vaginal microflora substances, particles and infectious by microscopic, cultural and agents movement into the uterine molecular methods. cavity and backward. During Results: The cytological pregnancy cervical canal (CC) investigations of smears from the protects the fetus and its envelopes surface of uterine neck and cervical from the contact with the external canal revealed that 6 patients environment, and during delivery CC (16.2%) only had no pathological supplies the partial loading mode of changes. Signs of inflammation were fetus yield from the uterus. found in 19 patients (51.4%): Inflammatory and neoplastic cervicitis – in 5 (13.5%), colpitis – in diseases of cervix uteri cause the 3 (8.1%), cervicitis and vaginitis – in injury of the CC epithelium. Recent 13 (35.0%) women. Ectopic time the intraepithelial changes of CC columnar epithelium and are accepted as main reason of the transformation zones were found in uterine neck tumor (UNT) which has 14 examined patients: 4 – without the rising trend overall the world. inflammation, 10 – associated with The aim of our research was inflammation, 5 – with inflammation the analysis of potential abilities of caused by human papilloma virus CC opportunistic screening in the (HPV), 1 – with erosion tissue diagnostics of CC diseases. injuring. In addition, LSIL was Materials and methods: The revealed in 2 patients, epithelium analysis of 37 women (from 20 to 64 atrophy in menopause – in 6 year old) examination results has patients, and hyperkeratosis of been done. Screening research squamous epithelium – in 1 woman. 172

ISIC-2016 Abstract book The colposcopy examination asymptomatic clinical course of revealed that in 97.3% cases of genital infections with the leading epithelium ectopy was accompanied role of HPV and Gardnerella vaginalis by inflammation. In 24.3% of cases as etiological agents. the atypia of squamous epithelium Conclusions: The results of was associated with HPV the research indicate that the chronic independently from the type of virus, inflammation is the most often in 10.8% of cases it was caused by reason of the CC pathology. As a other factors. Infections screening usual, its significant etiological factor allowed to define the following is asymptomatic mixed-infection. etiological microorganisms causing Opportunistic screening of CC genital infections: HPV – 28.5%, comprising colposcopy, cytological Gardnerella vaginalis – 12.5%, and microbiological examinations is Chlamydia – 9.6%, Mycoplasma – the highly informative method of 8.9%, HSV – 8.7%, Candida albicans – early detection and identification of 8.1%. We would like to point out the CC pathology.

Chernova I.G, Naumova E.N. ADENOMYOSIS TREATMENT IN WOMEN OF REPRODUCTIVE AGE Research Advisor: Tkacheva Olga, PhD Department of Obstetrics and gynecology #1 Kharkiv National Medical University Kharkov, Ukraine

Actuality. One of the most The aim. Clinical valuation of debated problems in modern the effectiveness of the drug indole- gynecology is the progression of 3-carbinol and the optimization of endometriosis after hormonal medical therapy among women with treatment. Surgical treatment, in adenomyosis in the reproductive spite of the improvement of age. techniques (use of endoscopic Materials and methods. We surgery, electrocautery, laser) examined 20 women with neither ensure complete elimination adenomyosis in reproductive age. of endometrial lesions, nor prevent The average age of patients was 36.5 recurrence of the disease. Nowadays + \ - 1.5 years. All patients received the major role is given to indole-3-carbinol 200 mg 2 times a phytonutrients (indole-3-carbinol) ‒ day for 3 months. Treatment efficacy plant derived substances capable to was evaluated on the basis of block the proliferative activity at the medical history, clinical and level of the target cells. 173

ISIC-2016 Abstract book ultrasound data after 3 months from patients (55%) the uterus the beginning of the treatment. corresponded to the size of 5 weeks Results. During of the analysis of pregnancy, in 7 patients (35%) ‒ 6 of clinical symptoms, the patients weeks of pregnancy, in 2 patients complained of general weakness, (10%) ‒ 8 weeks. undue fatigability, decreased of Evaluation of the effectiveness working capacity ‒ 10 woman of monotherapy by indinol-3- (50%). Menstrual dysfunctions were carbinol conducted under clinical the following character: symptoms and results of ultrasound hyperpolymenorrhea in 14 cases scan. After the 3 months of clinical (70%), acyclic bleeding in 8 cases examination was noted the (40%), algodismenorrhea in 16 cases improvement of the state of 40% (80%), pelvic pain without women: metrorrhagia ‒ 50%, association with menstruation in 4 hyperpolymenorrhea ‒ 40%, cases (20%), dysuric syndrome in 5 algodismenorrhea ‒ 55%, pelvic cases (25%). pains ‒ 50%. We study the Analysis of the anamnestic corpulence of the wall of uterus: data detected the high level of before treatment ‒ 30 mm, after somatic diseases: arterial treatment ‒ 26 mm. So, the clinical hypertension in 3 patients (15%), effect of the monotherapy by indinol- chronic diseases of hepatobiliary 3-carbinol was 50% without any system and gastrointestinal tract in negative effects. 12 cases (60%), varicose disease of Conclusions. At the modern lower extremities venous in 4 cases stage of the treatment of (20%), pathology of thyroid in 2 adenomyosis, the most pathogenetic cases (10%), obesity in 4 cases based therapy is acting on the (20%), fibrocystic breast mastopathy processes of regulation of cell in 6 cases (30%), anemia in 5 cases proliferation, invasion and apoptosis. (25%). It’s expedient to use them for the During of the ultrasound initial manifestations of adenomyosis examination of the size of uterus we in women of reproductive time. got the following results: in 11

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ISIC-2016 Abstract book Douglas B. I., Alabo Y. J. ABORTION’S AFTERMATH. WHAT IS ABORTION? Research Advisor: the Master of Medicine Romanenko A. O. Department of obstetrics and gynecology№2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Abortion is the studies for 10 countries where ending of pregnancy by removing a abortion is highly restricted; and fetus or embryo from the womb worldwide and regional estimates of before it can survive on its own. An unsafe abortion from the World abortion which occurs Health Organization. spontaneously is also known as a Results. Approximately 26 miscarriage. An abortion may be million legal and 20 million illegal caused purposely and is then called abortions were performed an induced abortion, or less worldwide in 2015, resulting in a frequently, "induced miscarriage". worldwide abortion rate of 35 per The word abortion is often used to 1,000 women aged 15–44. Among mean only induced abortions. When the sub regions of the world, Eastern an abortion (or miscarriage) takes Europe had the highest abortion rate place by itself, without any outside (90 per 1,000) and Western Europe aid, it’s called spontaneous abortion. the lowest rate (11 per 1,000). Types of abortion: induced abortion Among countries where abortion is and spontaneous abortion. legal without restriction as to reason, Materials and methods. the highest abortion rate, 83 per Numbers and rates of induced 1,000, was reported for Vietnam and abortions were estimated from four the lowest, seven per 1,000, for sources: official statistics or other Belgium and the Netherlands. national data on legal abortions in 57 Abortion rates are no lower overall countries; estimates based on in areas where abortion is generally population surveys for two countries restricte without official statistics; special

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ISIC-2016 Abstract book Dynnik Oleksandra, Nebesna Hanna FEATURES OF SONOGRAPHIC INDICES OF THE SMALL PELVIS ORGANS IN GIRLS WITH ABNORMAL UTERINE BLEEDING Research advisor: Prof. Mertsalova Olga Department of obstetrics and gynecology №1 Kharkiv National Medical University Kharkov, Ukraine

Actuality: Negative tends, <0.01) has been registered in them preserved in regard to the reliably more frequent. This reproductive capacity of adolescent thickness of the endometrium has girls, testify to the fact that been observed with similar development and introduction of the frequency in all three groups, current technologies make it irrespective of the disease course (gr. possible to increase the effectiveness I- 60.9%, gr. II - 60.3%, and gr. III - of prevention and treatment of 68.4%). gynecological diseases in this group Comparative analysis of the of patients. ovarian echosonograms in the The aim:Our study was groups of our patients has shown no designed to determine the significant difference between them characteristic features of with respect to their size. But it has echosonografic indices of the turned out that follicles with the internal genitalia in female diameter more than 10 mm adolescents with abnormal uterine visualized in the ovarian bleeding (AUB). echostructure in a certain percentage Materials and methods: of girls, and in some of our Ultrasound parameters of the adolescents it reached 30 mm or internal genitalia were estimated in more (this is regarded as ovarian 161 patients with AUB which were cysts). The proportion of girls with divided into three groups depending persistent follicles and/or ovarian on the BMI. Gr. I included 65 patients cysts in gr. Ι amounts to 33.9%, in gr. with the BMI standard values, gr. II ΙΙΙ - 44.7%, and in gr. ΙΙ -20.7%, comprised 58 girls with overweight, which is significantly less frequent and gr. III - 38 patients with body than in the other groups (p1 <0,03; weight deficiency. p2 <0,001). Results. Physiological Analysis of the uterus size in echosonografic parameters were girls with the absence or presence of observed much less frequent in insulin resistance has found that only adolescents from gr. IΙ, but an in patients from gr. Ι and ΙΙΙ with a increased size of the uterus (48.3% v. rise in the level of immunoreactive 38.2% in gr. I and 34.2% in gr. ΙΙ, P insulin and the HOMA index the

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ISIC-2016 Abstract book percentage of patients with an Attention is attracted by the enhanced size of the uterus (gr. I- fact that endometrial hyperplasia in from 22.2% in patients without IR to almost half of patients from gr. Ι and 60.7% with IR, p <0,001; gr. ΙΙΙ - from ΙΙ is combined with hyperinsulinemia 26.7% without IR to 66.7% with IR, p (gr. I - 42.3% and gr. II - 50%). <0,001) is increased significantly. We Conclusion: Thus, can assume that hyperinsulinemia at echosonography in childhood puberty may stimulate the growth provides sufficient information on through the direct anabolic effect of the small pelvis organs and is an insulin, that is to contribute to an important method in the diagnosis of increase in the uterus size in girls the reproductive system pathology. without overweight.

Fedziukova L. SURGICAL DELIVERY IN MODERN OBSTETRICS Research advisor: Korbut I., Candidate of Medical Science, Associate Professor Department of obstetrics and gynecology Gomel State Medical University, Gomel, Belorussia

Actuality. The most common Results. Patient in group B were methods of operative delivery with a significantly more likely primigravidas live fetus is a cesarean section and (χ2 =2,93, p <0.005) and nulliparous vacuum -extraction of the fetus. (χ2 = 2,38, p <0.02). Women in both Indications for cesarean section is groups had similar gynecological much wider than for vacuum history, but pregnancy loss were extraction, but through the work we diagnosed only in patients deliveried considered acute fetal hypoxia and with caesarean section.Blood loss in birth weakness. group A was 663 ±78 ml in group B - Aim. Compare the effect of 317±52 mL, Z =-6,9, p<0,001. mode of delivery on the condition of White blood cells in the 3-4e day after the mother and child. delivery of 11 * / l and more in group Matherials and methods. A -58,3±8,2%, group B -72,7±7,6%. In Statistical processing performed with women with cesarean section after the help of applications Microsoft delivery leukocytosis was more Office: quality - Me (25; 75 percentile), pronounced than in women with quantitative - n, p ± sp%, statistically vacuum extraction. significance p <0.05 features. It was Assessment of children Apgar after 1 formed two groups of women (A - minute of life in group A - 8(8,8), in Caesarean section n = 36, B - vacuum group B - 7(6.8) b; After 5 minutes in extraction n = 33). group A- 8 (8.9) b, in group B - 8(7.8)

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ISIC-2016 Abstract book b. When using the vacuum extraction birth weight in group A 41,7 ± 8,2%, in children born in hypoxia significantly group B-36,4 ±8,37%. higher (χ2 =3,0, p <0,005). Premature rupture of membranes in Conclusions. Thus, with similar Group 1 was at 63,9 ± 8,0% people, in indications for operative vaginal group 2 - 42,4 ± 8,6%. Green was the delivery, maternal safer mode of color of amniotic fluid in 13 patients delivery is a vacuum extraction of the (36,1±8,0%) and 9 (27,3±7,6%) fetus. For more optimal fetal cesarian patients, respectively. section. Children born with hypoxia Weight at birth in group A - 3435g less, more important adaptation fetus (3190; 3753) g, in group B - 3500g than the weight loss during the first (3330; 3760). For 6-7 days not reached day.

O. V. Gnatenko, S. V. Kebashvili CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF ADNEXAL TORSION IN CHILDREN AND ADOLESCENTS Research advisor: Tuchkina I. Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical Iniversity Kharkiv, Ukraine

Actuality. One of the most The aim was to study the frequent causes of children incidence of adnexal torsion in admission to the surgical department children and adolescents. is conditioned by abdominal pain, Materials and methods. The which can often result from study involved clinical and statistical gynecological diseases, particularly analysis of medical records of adnexal torsion (in 2-3% of cases). patients with diagnosed adnexal Adnexal torsion develops much more torsion, who underwent inpatient commonly in children and treatment at gynecologic department adolescents than in adult women, of Kharkiv Regional Children's which is due to anatomical features Clinical Hospital from 2010 to 2016. of internal genital organs (small size Results and their discussion. of the uterus, a relatively high The assessment of the records for location of the ovaries in the small the period under investigation pelvis), physiological characteristics showed that adnexal torsion was (overload of the bladder, juvenile diagnosed in 30 patients, including constipation, overactive intestinal 11 girls under 12 years of age and 18 peristalsis), as well as more mobile adolescents. Solitary torsion of the lifestyle inherent to this age group. ovary was observed in 12 patients, 178

ISIC-2016 Abstract book torsion of an ovarian cyst - in 10, flow and without necrotic changes torsion of a paratubal cyst - in 5, underwent detorsion while adnexa torsion of the ovary and fallopian with absent blood flow and presence tube - in 2, torsion of ovarian of necrosis were removed. teratoma - in 1. The treatment Conclusion. All cases of included 28 surgical operations by suspected adnexal torsion in laparoscopy and 2 operations by children and adolescents need to be laparotomy. Organ-preserving comprehensively diagnosed. surgical treatment implied Minimally invasive organ-preserving determination of the state of adnexal laparoscopic intervention should be tissues: patients with intact blood considered the method of choice.

O. V. Gnatenko, S. V. Kebashvili CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF ADNEXAL TORSION IN CHILDREN AND ADOLESCENTS Department of Obstetrics, Gynecology and Children Gynecology Scientific supervisor: Doctor of Medical Science, Professor I. A. Tuchkina Kharkiv National Medical University Kharkiv, Ukraine

Actuality. One of the most The aim. To study the frequent causes of children incidence of adnexal torsion in admission to the surgical department children and adolescents. is conditioned by abdominal pain, Materials and methods. The which can often result from study involved clinical and statistical gynecological diseases, particularly analysis of medical records of adnexal torsion (in 2-3% of cases). patients with diagnosed adnexal Adnexal torsion develops much more torsion, who underwent inpatient commonly in children and treatment at gynecologic department adolescents than in adult women, of Kharkiv Regional Children's which is due to anatomical features Clinical Hospital from 2010 to 2016. of internal genital organs (small size Results. The assessment of the of the uterus, a relatively high records for the period under location of the ovaries in the small investigation showed that adnexal pelvis), physiological characteristics torsion was diagnosed in 30 patients, (overload of the bladder, juvenile including 11 girls under 12 years of constipation, overactive intestinal age and 18 adolescents. Solitary peristalsis), as well as more mobile torsion of the ovary was observed in lifestyle inherent to this age group. 12 patients, torsion of an ovarian 179

ISIC-2016 Abstract book cyst - in 10, torsion of a paratubal changes underwent detorsion while cyst - in 5, torsion of the ovary and adnexa with absent blood flow and fallopian tube - in 2, torsion of presence of necrosis were removed. ovarian teratoma - in 1. The Conclusion. All cases of treatment included 28 surgical suspected adnexal torsion in operations by laparoscopy and 2 children and adolescents need to be operations by laparotomy. Organ- comprehensively diagnosed. preserving surgical treatment Minimally invasive organ-preserving implied determination of the state of laparoscopic intervention should be adnexal tissues: patients with intact considered the method of choice. blood flow and without necrotic

Hasan A. ROLE OF THE METHODS OF OVUM EXTRUSION IN THE PREVENTION OF SECONDARY TUBOPERITONEAL INFERTILITY DURING ECTOPIC PREGNANCY TREATMENT Research Advisor: PhD, Associate Professor Saltovsky A. Department of Obstetrics and Gynecology №1 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Method of extrusion patients with EP treated by of the ovum (MEO) has been uncomplicated organ-preserve successfully used in the treatment of surgery by the MEO on a single FT in ectopic pregnancy (EP) progressing the term up to 6 obstetrical weeks in terms of up to 6 obstetrical weeks. was carried out. Postoperatively, all At clearly less traumatization of patients obtained the therapeutic fallopian tubes (FT), this method and prophylactic courses of complex allows preserving FT in most cases, antibacterial and anti-inflammatory but the assessment of delayed MEO therapy. The results of the research outcome is debatable. were clinically evaluated by the The aim of the work was to degree of tubal patency according determine the frequency of culdoscopy in the late postoperative occurrence of FT occlusion and period and metrosalpingography pregnancy after EP treatment by (MSG) at 6 months after surgery as MEO in patients with a single stored well as by the percentage of FT. pregnancy in these patients after EP. Materials and Methods. Results of the study. Analysis of 34 medical records of Development of FT occlusion was

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ISIC-2016 Abstract book observed in 20.6% of patients (7 Conclusions. Thus, the patients), limiting of the contrast obvious high effectiveness of this agent spreading in the abdominal method makes it preferred in cavity was in the 11.8% of cases (4 laparoscopy on the progressive EP, patients). Pregnancy occurred in 20 and in the future, perhaps, the "gold cases: intrauterine in 17 patients standard" in treatment of EP with (50%), ectopic in 3 patients (8.8%). simultaneous prevention of tuboperitoneal infertility.

P. A. Alieva, S. E. Malikova, S.S. Filatova, T. A. Ivanova IMPROVEMENT OF TREATMENT EFFICIENCY IN CHRONIC INFLAMMATORY DISEASES OF UTERINE ADNEXA Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Inflammatory associated with many adaptation diseases of the female reproductive processes in the female body. system prevail among gynecologic Materials and methods: The abnormalities and their frequency study implied examination of comprises up to 70%. Chronic genital reproductive age patients, diagnosed and extragenital conditions remain with CIDPO, who underwent in- most challenging in diagnosis and patient treatment at gynecological differentiation, as their treatment is department of Kharkiv Maternity associated with specific pathogenic Hospital No.1 in the years 2014- mechanisms of their development. 2015. Main clinical symptoms The relevance of this problem is included pain (65.6%), conditioned by a number of dysmenorrhea (51.1%), dyspareunia significant long-term consequences (27.9%), MDs as for women's health, such as hyperpolymenorrhea (34.4%) and secondary infertility, menstrual oligoopsomenorrhea (14.4%). disorders (MDs), ectopic pregnancy Bacteriologic findings in patients and pelvic pain syndrome. Chronic with CIDPO revealed different types inflammatory diseases of the pelvic of coccobacillary microflora, organs (CIDPO) should actually be chlamydia, ureaplasma, with the considered as polysystemic predominance of microbial disorders involving complexes, associations in most cases. Thiopoetin class of drugs (Glutoxim) 181

ISIC-2016 Abstract book was given priority in adrenal system and MDs, immunocorrective therapy. improvement of hemodynamic Conclusions: Studies have parameters and elimination of shown that immunocorrective endothelial dysfunction, which treatment results in a rapid and substantially improves the results of significant reduction of pain treatment and prevents relapses of syndrome, normalization of the disease in future regulatory function of sympathetic- .

Jacobs Y., Romanenko A.A. PRIMARY CESAREAN DELIVERY INCREASES RISK IN THE NEXT PREGNANCY Research advisor: Romanenko A.A., magister of medicine Department of obsterics and gynecology N2, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. A Caesarean section, gestational age and obstetrics history also known as c-section is a surgical (ectopic pregnancy, miscarriage, still procedure in which incisions are birth or termination). made through a mother’s abdomen Results. More women who had and uterus to deliver one or more previous caesarean delivery were 30 babies. years or older compared to those The aim to analyze the who had a previous vaginal delivery. difference and risk in second Conversely, fewer women in the pregnancy outcomes between previous cesarean delivery group women who had a previous were smokers or had pregnancy caesarean delivery and those who interval less than 15 months. Women had a previous vaginal delivery. who delivered their child by Materials and methods. cesarean section had a significantly Population based retrospective study increased risk of adverse outcomes of all second birth, comparing in their second pregnancy including outcomes of 30 women who placenta previa, antepartum underwent a caesarean delivery for hemorrhage, malpresentation, the first birth with 800 who prolonged labour and cesarean underwent a vaginal first birth. The delivery. The risk of emergency statistical analysis adjusted for age, cesarean delivery increased the indigenous status, smoking status, most. Rare events such as placenta pregnancy interval, medical accreta and uterine rupture also conditions (hypertension, diabetes were significantly more common in or asthma), obstetrics complications, mothers who delivered their first 182

ISIC-2016 Abstract book child by c-section. Also two maternal different, a first cesarean delivery is death occurred in the previous associated with increased risk of cesarean delivery group (one from adverse outcomes in subsequent hemorrhage following hysterectomy pregnancy and the risk of recurrent for placenta accreta and one from cesarean deliveries are additives. I amniotic fluid embolism following believe these findings have serious uterine rupture). There were no implications for women who elect to maternal deaths in vaginal delivery have first child through a cesarean group. Infants whose mothers had a delivery and however if these risk previous cesarean delivery had an fully explained to the woman, she increased risk of being small for should be allowed to choose to gestational age, premature or accept one set of risk above the stillborn. other. Conclusion. Therefore the risk of cesarean section and Labor are

Kambinda Dricky Nasilele GESTATIONAL DIABETES AND MEDICAL TREATMENT Research advisor: Gradil O. Оbstetrics and gynecology №2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Gestational Diabetes women with Gestational Diabetes Mellitus is defined as high blood Mellitus using Medication and a glucose level in a pregnant women Special diet. The special diet was who never had diabetes. Gestational 1.Plenty of water 2.Take small Diabetes affects up to 15% of women quantity of breakfast (because blood worldwide. glucose is not easy to control in the The aim was to improve the morning due to the release of health of women and to avoid hormones that boost the blood complications of mother and sugar).3. 25 to 40 g of carbohydrates newborn during pregnancy and in the morning and 50 to 60g of birth. To determine the benefits of Carbohydrates for lunch and dinner, treatment on women with eg whole-grain bread Gestational Diabetes Mellitus and products).4.Protein e.g meat, cheese, their Newborn babies. eggs, nuts, peanut butter, fish, Matherials and methods. The turckey etc. 5.Vegetables eg lettuce, study was conducted on 46 pregnant okra, mushrooms, brocoli carrots, 183

ISIC-2016 Abstract book cabbage etc. 6.Fats e.g nuts, salmon complications of pre-eclampsia, and fish avocados etc.7 Getting enough almost 87% gave birth with rest and avoid stressful situations. ceaserian section. Result.The 46 pregnant Conclusion. Pregnant women women with gestational diabetes with Gestational Diabetes and their where divided into two groups, 23 newborn who were on put on women were put on traditional treatment and the special diet had treatment and the special diet and less complications such as pre- the other 23 women only traditional eclampsia, macrosomia, dystocia, treatment .Women who were on less admission to intensive care unit medication had less cases of and less delivery with cesarean cesearean section and section while pregnant women and hypertension/pre-eclampsia in fact their babies with gestational their blood pressure was well diabetes without treatment showed controlled, they were less 97% complications. Treating complications such as hypoglycemia, Gestational Diabetes Mellitus results preterm birth with respiratory in less complications in both mother distress syndrome ,microsomia and and the baby and improves their no admissions to intensive care unit health. So it goes on to show that of neonates with women with treating Gestational Diabetes has gestational diabetes. With women on great health benefits on both the observation showed a lot more mother and her baby .

Kluiunyk M.V., Kolganova N.L. SPECIFIC DERMATOSES OF PREGNANT WOMEN Research advisor: Belovola A.N., Professor Department of dermatology, venereology and medical cosmetology, Kharkiv National Medical University, Kharkiv , Ukraine

Actuality. During pregnancy pregnant woman. Therefore this kind women’s skin has a lot of functional of diseases can be harmful for fetus. changes. There is group of specific The aim. To find out several skin diseases which we can see groups of specific dermatoses of during pregnancy or/and after pregnancy. childborn. This problem is very Materials and methods of important in obstetrics and in research. Material were data of 75 dermatology, because skin diseases, patients surveyed in the last 2 years in most cases, has negative impact on about various diseases of the mental and emotional condition of a abdominal and thoracic cavities. 184

ISIC-2016 Abstract book Diaphragms with pathology were Umbilical region doesn’t involve in excluded. Analysis and image the pathological process; on mucous processing were performed on a it didn’t describe. Itching of pregnant workstation "HP-Z820" with special it can more often observes in person software "Vitrea 2".Gender-based who has atopic diseases in cases were: male – 61 and female – anamnesis. The disease appears by 14 cases. Age interval from 26 to 82 itching in combination with small years old, according to the type of (<0.5 cm) red or flesh-colored the structure revealed the following papules, in more cases it located on relationships – male hypersthenics – the skin of the body and extensor 35%, normosthenics – 60%, surfaces of limbs. Itchy folliculitis of asthenics – 15%; for female pregnant. At present time scientists following ratio was 30%, 50% and don’t know about pathogenesis of 20% accordently. this disease. Maybe, mechanism of The results. Based on analysis development, similar to the of scientific literature we found out mechanism of development of several groups of specific steroid acne (acne on the dermatoses of pregnancy. background of using systemic Pemphigoid of pregnant - hormone- corticosteroids or progesterone).The mediated, autoimmune disease that disease doesn’t recur. The disease develops in association with characterize by severe itching and pregnancy, a molar pregnancy and eruption of small, red follicular even the chorioepithelioma. If you papules which located on the upper had this disease one time, it will of body. come back again. Urticarial rash Conclusion: Thus, based on takes form of plaques, strips and literature which we reviewed, we concentric rings. In further bubbles can conclude that the problem of the and bubbles, accompanied by severe specific dermatoses of pregnancy is itching. In most cases the process important for both obstetrics and begins in the region of navel and dermatology. First of all because of then spreads to the skin of the the negative impact skin diseases on abdomen, thighs, palms, soles, rarely mental and emotional condition of on mucous. Polymorphic rash of the pregnant woman, therefore it can pregnancy appear in late of be harmful for fetus. You must pregnancy and/or after childbirth. exercise special care in the treatment There are three main theories: of these dermatoses. There are two excessive stretching of the stomach, specialists who should carry about hormonal factor, embryonal factors. pregnant woman with specific It starts of urticarial papules, usually dermatoses: obstetrician - on the fringes of sprains. Often rash gynecologist and dermatologist. connects with another rashes, then it Treatment depends on the clinical can looks like a toxic erythema. picture, and gestational age. 185

ISIC-2016 Abstract book

Konoval A. THE IMPACT OF IMMUNOMODULATORY THERAPY ON THE MICROBIAL ASSOCIATIONS IN WOMEN WITH CSO Research advisor: Paraschuk Y., Doctor of Medical Science, Professor Department of obstetrics and gynecology №2, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality: Insufficient efficacy follows: group 1 – women with CSO of the therapy of ascending infection, receiving standard therapy; Group 2 leading to the chronic – women with CSO who received the salpingoophoritis (CSO) to a certain therapy including an extent is attributed to the presence immunomodulating drug. of the defense mechanisms of Results: Results of the pathogens of damaging factors. pathogen testing of vaginal Research of biofilms allows to detect secretions on the ability to form informative criteria for the biofilms showed that all isolated assessment of the earliest pathogens have formed dense mechanisms of adaptive responses of biofilms in the patients of group 1 microbes to the action of various and 2 before therapy. factors, and to define the therapy After conduction of therapy in which will prevent the formation of women with CSO it was found that biofilm spread. the optical density of daily isolate The aim: Diagnostic biofilms had been significantly confirmation of the use of decreased. However, it was found immunomodulatory therapy in that after the proposed treatment women with CSO against a performed in women of group 2 the background of determination of the density of daily biofilms E.coli was ability of microorganisms to form inhibited in 2.9 times, while in biofilms. women of group 1 – in 1.9 times; in Materials and methods: women of group 2 the density of determination of the density of daily biofilms S. epidermidis was biofilms of vaginal secretions due to inhibited in 5.1 times, and in women the coloration with gentian violet of group 1 – in 2.7 times; with further microscopic evaluation Enterobacter – in women of group 2 in 70 women with CSO compared the density of daily biofilms was with a group of healthy women (n = inhibited in 6.5 times and in women 35). The groups were divided as of group 1 – in 3.4 times;

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ISIC-2016 Abstract book Actinomyces spp. – in women of Conclusion: So the application group 2 the density of daily biofilms of immunomodulating biological was inhibited in 6.8 times and in agents in CSO inhibits the ability of women of group 1 – in 3.9 times; S. pathogens of vaginal secretions to pyogenes – in women of group 2 the form dense biofilms as one of the density of daily biofilms was major factors of pathogenicity of inhibited in 5.9 times and in women microorganisms. This enables of group 1 – in 3.2 times; Candida antimicrobial medications to spp – in women of group 2 the perform their function to the extent density of daily biofilms was necessary to eliminate the pathogen inhibited in 7.5 times and in women from the body, since the biofilms are of group 1 – in 4.1 times; S. aureus – formed in the presence of microbial in women of group 2 the density of associations, which in turn are daily biofilms was inhibited in 5.4 multiresistant to antimicrobial times and in women of group 1 – in therapy. 2.7 times.

Litvinova A. FEATURES OF PREGNANCY COMPLICATED BY PREECLAMPSIA AND ANTIPHOSPHOLIPID SYNDROME Research advisor: Tuchkina I., Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. Antiphospholipid weeks of gestational. Women were syndrome (APS) is one of the reasons divided into 3 groups. The 1 group for the development of obstetric and consisted of 27 pregnant with extragenital pathology. Importance is preeclampsia of varying severity and assigned to the antiphospholipid an increased level of antibodies to antibodies (APA), because their play cardiolipin (ACL) and β2 – an important role in vascular wall glycoprotein 1 (GP1). II group damage that underlies the consisted of 31 pregnant with pathogenesis of preeclampsia. preeclampsia and physiological level The aim: the study to ACL and β2GP1. The control group investigate the characteristics of consisted of 25 pregnant with products AFA in pregnant women physiological pregnancy. All with preeclampsia. pregnant underwent a clinical Material and methods. examination and laboratory findings, Examined 83 pregnant at 22 to 38 a study of indicators of coagulation 187

ISIC-2016 Abstract book and anticoagulation systems, the umbilical artery, which can be level ACL, anti-β2 GP-1, antibodies to explained by preeclampsia, cjnstant prothrombin and anexin V. of pathological products APA Results. Analysis of severity of enhanced thrombotic tendency pre-eclampsia showed that pregnant leading to the violation of the utero- in the group with pathological levels fetal blood flow. In the 1 group, these of APA were significantly more changes occurred in 22.1% of cases, frequent was presence of pre- and in II – 4.4% ( p<0.05). eclampsia severe – 25,0%, in the II Analysis of pregnancy group, severe preeclampsia is absent outcomes showed that the date of (p<0.05 ). Revealed earlier delivery in 1, and ІІ groups of development of preeclampsia in pregnant women with preeclampsia pregnant with pathological level APA (36,2±0,5 weeks) and (36,8±0,3) was (13.8% of patients of the 1st group in significantly earlier (p<0.05) than the 22-24 weeks). It was found that the control (39,1±0,1). for pregnant women with Conclusions. On the pathological level APA is pathological level of APA characterized by an earlier and more accompanied the earlier severe pre-eclampsia. development and more severe Installed a significantly higher course of preeclampsia, leads to the level of autoantibodies to β2 GP-1 deterioration of the fetus, classes IgM, IgG, antibodies to anexin accompanied by an increase in the V class and IgM antibodies to number of premature labor and the cardiolipin. birth of children with grous In the presence of retardation. For the prevention and preeclampsia on the background of treatment of pregnant with the pathological level of antibodies preeclampsia, it should be surveys significantly more frequently. The for the APA, β2-GP1, prothrombin results of Doppler blood flow in and anexin V.

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ISIC-2016 Abstract book Miroshnichenko Y.N., Tverezovskaya I.I. APPLICATION OF LETROZOLE IN ENDOCRINE STERILITY TREATMENT Scientific adviser: teaching assistant of the department of obstetrics and gynecology № 1 KhNMU, Gorbatovskaya E.V., PhD Department of obstetrics and gynecology № 1, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Endocrine sterility medical preparations have been used occupies one of leading positions for 4 months. among different reasons of female Results. After having sterility that combine all conditions undergone a treatment course 82% connected with ovulatory failure. In of patients had restoration of ovarian the structure of female sterility a function, 39 % of them got pregnant. frequency of endocrine form range to After dose titration to 5,0 mg, the 40 %. rest 90 % of women got pregnant. On The aim of the research is to the top of already administered expose peculiarities of mechanism of therapy thinning of functional action aromatase inhibitor letrozole endometrial layer and reducing of in patients with sterility caused by glands secretion were not observed. polycystic ovary syndrome. Conclusion. Ovarian Materials and methods. There hyperstimulation of aromatase were 28 women 20-28 years old with inhibitor letrozole is an effective polycystic ovary syndrome (average method of ovarian stimulation in age is 24±1,8). All patients had patients with endocrine sterility. complete pelvic examination for co- Application of medicaments results morbidity detection of reproductive in restoration of ovulation and female system and contraindication pregnancy. It is also exposed that to this type of therapy. Selected letrozole has dose-dependent effect on dominant follicle growth.

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ISIC-2016 Abstract book Alisa Nagieva MODERN APPROACHES TO THE ISSUES OF IMMUNOLOGICAL INFERTILITY DIAGNOSTIC Research advisor: ass. prof. Vesich T.L. Department of obstetrics and gynecology №1 Kharkiv National Medical University Kharkov, Ukraine

Actuality: There are a lot of  MAR- test - the percentage of reasons of infertility emergence but sperm covered by SAB. one of the main causes is problems Results: To determine the with immunity and this problem predictive value of immunological hold 3rd place by criteria of infertility diagnostic methods, an frequency of occurrence. experiment was carried out. In Materials and methods: experiment participate 20 couples Those contraventions are usually with infertility: they are a study connected with forming of sperm group. And 20 couples who have antibodies (SAB). A degree of children: they are a control group. impaired fertility will depend on Results of test-contact showed that 5 quantity of SAB, that will be a cause couples (25%) from study group of impaired spermatogenesis. have SAB. In control group there According to the statistics if men were 4 couples (20%) with SAB. But have SAB it will lead to infertility in MAR- test showed that 8 infertility 10-20%. To diagnose immunological couples (40%) had SAB, when from infertility next methods are used: control group there was only one  postcoital test (PCT) – couple (2%). estimate the compatibility between sperm and cervical mucus; Conclusions: Taking into  test contact - estimation of account the data of the experiment, penetrating ability of sperm in the MAR-test is recommended as a cervical mucus; required method when examining infertile couples.

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ISIC-2016 Abstract book Nesteruk A.V. CYTOKINE PROFILE AS DIAGNOSTIC CRITERION IN PERINATOLOGY Research Advisor: PhD, Associate Professor Plachotnaya I.Y. Department of Obstetrics and Gynecology №1 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: In accordance with Materials and Methods: The the statistical study carried out by study included 24 pregnant women, Ginsburg in 2010, early perinatal who were divided into 2 groups. The mortality in Ukraine is about 3 cases first group (basic) included 14 per 1,000 live births. This is in great women with realization of IUI in the part due to the infectious newborn in early neonatal period, complications in children arising the second (control) - 10 patients because of intrauterine infection without the implementation of IUI in (IUI) of mother. Early detection of newborns. The content of cytokines IUI is not always possible due to the IL-1β, TNFα, IL-6, IL-8, IL-10 were nonspecific symptom. examined.Women age ranged from Chronic persistent infection 22 to 39 years and was averaged contributes to the maintenance of 31.0 ± 0.5 and 28.0 ± 0.5 years, permanent high levels of innate respectively. In analyzing the immunity factors due to the effect on structure of extragenital diseases of the cell Toll-receptor system. mothers there was a significant Receptor activation leads to the increase in the incidence of chronic cytokine release and implementation diseases of upper respiratory tract of inflammatory response. (32.3%), chronic kidney disease Presumably, the levels of pro- and (25.1%), cystitis (30.2%), p <0.05. In anti-inflammatory cytokines may the basic group, the opportunistic allow predicting the implementation vulvovaginal infection (43.5%), of infectious complications in the carriage of herpes simplex virus children who are born to mothers (42.1%), candidiasis (35%), with IUI. ureaplasma (36.4%), p <0.05, were Aim: Determination of the more common. criteria for the diagnostic of early In the quantitative study of neonatal complications based on a pro-inflammatory cytokines in study of pro- and anti-inflammatory pregnant women who gave birth to cytokines in the blood serum and the children with IUI, there was a contents of the posterior vaginal significant increase in the serum fornix (PVF) of pregnant women levels of IL-8 (16.73±1.7 pg/ml, p = with IUI. 0.021) and IL-6 (38.4±3.5 pg/ml, p = 0.032). The contents of the PVF had

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ISIC-2016 Abstract book elevated cytokine levels of IL-6 anti-inflammatory cytokine IL-10 (89.41±6.5 g/g) and IL-1β and increase of pro-inflammatory (157.2±13.4 g/g), p<0.05. Anti- cytokines IL-6, IL-8 at the systemic inflammatory IL-10 in the serum of level as well as an increase of pro- pregnant women was reduced 6 inflammatory cytokines IL-1β, IL-6 at times compared to the control group, the periphery. Based on these data it average was 3.99±2.2 pg/ml, p = is possible to develop diagnostic 0.011). criteria, the use of which will reduce Conclusions: In result of the risk of infectious complications examination of pregnant women in newborns. with IUI implementation in neonates it has been shown an decrease of

Novikova Anastasia CLINICAL AND ETIOLOGIC CHARACTERISTICS OF ABNORMAL UTERINE BLEEDINGS IN ADOLESCENT GIRLS Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Abnormal uterine presentation of new abnormal bleedings of puberty (AUBP) are one uterine bleedings in adolescents. of the most severe gynecological Materials and methods: diseases in adolescents constituting Assessment of medical records of 11- 20-30% of all gynecological diseases 17-year-old adolescents with AUBP in this age group. Issues of diagnosis, for the years 2014-2015 was treatment and rehabilitation of performed at the Department of patients with AUBP remain relevant, Obstetrics, Gynecology and Children since recurrence worsens prognosis Gynecology (Regional Children regarding reproductive function in Clinical Hospital No.1 and Kharkiv these patients, which is still an Maternity Hospital No.1). important social and economic Results: The study of medical problem. records showed that 70% of patients The aim of our study was to developed AUBP at the age of 14-16 evaluate clinical and etiological years, the majority of patients features of the development and (77.5%) had new-onset bleedings and 22.5% of adolescents suffered 192

ISIC-2016 Abstract book from recurrent bleedings. Of these, chronic extragenital diseases 80% of girls did not undergo (chronic gastritis, pyelonephritis, rehabilitation after the new-onset disorders of the nervous and bleeding and did not seek endocrine systems). gynecological help to restore Conclusions: Thus, the study menstrual function. showed that AUBP more commonly The findings revealed that 55% occurs in adolescent girls 2-3 years of patients had such family histories after menarche. The study also of reproductive disorders as determined multifactorial etiology of maternal menstrual dysfunction this disease: the impact of adverse (MD), complicated perinatal period perinatal period and premorbid (hypoxia during labor, birth trauma, background, the presence of intrauterine pneumonia and other) extragenital pathology, as well as in 45% of patients. The majority of hereditary predisposition to MD. patients were found to develop Absence of rehabilitation after new- AUBP at unfavorable premorbid onset bleeding is regarded as a risk background: 67.5% of them had factor of recurrence, which indicates frequent acute respiratory viral the need for careful clinical infections and sore throat in examination of these patients in prepubertal period. Besides, 60% of order to restore menstrual function patients were diagnosed with during routine clinical examination.

O. V. Gnatenko, A. M. Prokopenko IMPROVEMENT OF DIAGNOSIS AND TREATMENT EFFICIENCY IN ACUTE ABDOMEN IN YOUNG FEMALE PATIENTS AND ADOLESCENT GIRLS Scientific supervisor: Doctor of Medical Science, Professor I. A. Tuchkina Department of Obstetrics, Gynecology and Children Gynecology, Kharkiv National Medical University Kharkiv, Ukraine

Actuality. The term "acute efficiency in pubertal patients and abdomen" is complex. It unites acute young women with gynecologic conditions of different etiology and disorders that triggered acute clinical presentation. Despite the abdomen. variety of etiologic factors its Materials and methods. The symptoms have many common study was performed at the features (I.A. Tuchkina et al, 2013). Department of Obstetrics, The aim of the study was to Gynecology and Children improve diagnosis and treatment Gynecology. It involved examination 193

ISIC-2016 Abstract book of 184 adolescents aged 11-18 years history and infectious index, the and young reproductive age women, course of pregnancy and labor, the who underwent treatment of acute degree of physical and sexual abdomen with differential diagnosis development, the character of between gynecologic and surgical menstrual disorders, gynecological abnormalities. status and functional status of the Results. Acute abdomen in ovaries. Hormonal profile was adolescents was due to pelvic tumors studied by the levels of luteinizing - 36%, congenital anomalies of the and follicle-stimulating hormones, uterus and vagina - 17%, ovulatory prolactin, estradiol and testosterone. syndrome and ovarian apoplexy - The study also determined physical 21%, acute appendicitis - 18%, health (consultation with a torsion of adnexa - 8%. Young pediatrician and specialists in women most often had inflammatory related fields), pelvic diseases of the internal reproductive echosonography, Doppler study of organs - 33%, ovarian apoplexy - uterine vessels and ovaries, 32%, pelvic tumors - 18%, vaginoscopy and colposcopy by endometriosis - 13%, ectopic indications and follow-up monitoring pregnancy, menstrual blood reflux, by a surgeon and a gynecologist adhesions after surgery on uterine (compulsory at the age under 18, by adnexa - to 4%. Acute abdomen in pediatric gynecologists and girls and adolescents with ovarian surgeons). tumors is often caused by torsion of Conclusion. Symptoms of cyst pedicle and uterine adnexa - acute abdomen in adolescents and 37%, hemorrhage into the cyst young women were triggered by capsule - 35%, rupture of cyst pelvic tumors in 36% and capsule - 23%, association with acute inflammatory pelvic diseases in 33% appendicitis - 5%. The authors cases. The diagnostic algorithm developed a diagnostic algorithm elaborated in the study promotes involving comprehensive clinical and early diagnosis and rational therapy laboratory examination, assessment with maximum preservation of of clinical presentation, premorbid reproductive organs in surgical background, evaluation of the early interventions.

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ISIC-2016 Abstract book Obinyan Ofure Abigael C-JUN INFLAMMATORZ PROTEIN; A NEW DIAGNOSTIC APPROACH TO THE DIAGNOSIS OF ENDOMETRIOSIS Research advisor: Professor Grigrovna Oxasana Obstetrics and Gynecology Department N2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Endometriosis, the each sample, 50 proteins were invasive displacement of uterine measured, including inflammatory tissue into surrounding organs, compounds known as cytokines. A affects at least 10 percent of women distinctive profile of cytokine activity worldwide. In patients with associated with certain symptoms, endometriosis, cells from the lining specifically ovarian and rectovaginal of the uterus flow into the fallopian lesions was identified. tubes and then into the peritoneal Results: One of the key cavity, where they implant on organs inflammatory regulators identified including the ovaries, colon, and from the peritoneal fluid sample diaphragm. This produces lesions analyzed was c-Jun, which is a that can cause pain ranging from protein that drives inflammation and mild to debilitating, and can lead to has been known to be strongly infertility. Endometriosis is difficult associated with endometriosis. c-Jun to study because it can appear and is a molecule that is secreted by disappear at different times in a macrophages, a type of immune cell woman's life, and the symptoms and that acts as a sentinel patrolling severity can vary greatly. tissues, digesting foreign material, Furthermore, the disease often goes and presenting it to other immune undiagnosed or misdiagnosed for cells. The link between the immune many years. activation of c-Jun inflammatory The aim of the investigation protein and development of was to study the various endometriosis is not clearly inflammatory proteins in patients understood. with suspected or diagnosed Conclusions: Identification of endometriosis so as to improve the c-Jun inflammatory protein in clinical method of investigating peritoneal fluid of patient indicates a endometriosis. strong suspicion for the diagnosis of Materials and Methods: endometriosis. With such revelation, Peritoneal fluid from 77 patients drugs that inhibit c-Jun protein can who reported a wide range of be used for the early treatment of symptom severity indicating endometriosis and can prevent the endometriosis was analyzed. For various complications such as pain

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ISIC-2016 Abstract book and infertility that most women encounter.

Oluwayemi M., Gradil O.G. THE NEW ASPECTS OF ENDOMETRIAL CANCER TREATMENT Research advisor: Gradil O.G., Ph.D. Department of obsterics and gynecology №2, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Endometrial cancer aim of “Therapeutic Improvement” is the fourth most common cancer in and the emerging likelihood of women with an estimated 46,470 endometrial cancer because of our new diagnoses and over 8000 deaths modified lifestyle plays a greater role in 2011. For patients with early stage in endometrial cancer development disease, hysterectomy is considered in every woman, especially those of curative. By contrast, advanced stage premenopausal age. The role played and high grade endometrial cancer is by the evolving therapeutic influence lethal. of Targeted Molecular Therapy has The aim is to increase shown great prognostic value for all awareness, and begin a fight against kinds of cancers it is optimized for, it industries that are aware of the would also improve the prognosis potential risk posed in form of side and increase the survival rate of effect after the use of some products, every patient suffering from producing a more reliable therapy endometrial cancer and even any and thereby reducing mortality. kind of cancer as a whole. Materials and methods. Conclusion. Despite the Retrospective analysis of 117 case questions and barriers, the histories of patients with incorporation of targeted molecular endometrial cancers. Cross analysis therapy into treatment regimens in of the etiological background, endometrial cancer is an exciting pathophysiology and prognosis of area of investigation with the these patients. Diagnostic methods potential to improve outcomes. such as General Clinical Examination, Outside of the development of a Biochemical analysis, ultrasound, CT reliable screening test for scan Histological study (biopsy). endometrial cancer, converting the Results. The insights into disease to a chronic state and hormonal therapy as a cure for other improving progression-free survival cancers, the role played by the is our best hope to reverse the pharmaceutical industries with the

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ISIC-2016 Abstract book concerning trend of decreasing 5 year survival for this disease.

I.K.Osovskiy, R. E. Blagoveshchensky, L. A. Grebenyuk ADMINISTRATION OF OCTAPLEX IN COMPREHENSIVE TREATMENT OF PATIENTS WITH PROFUSE OBSTETRICAL HEMORRHAGE Research advisor: Tuchkina I. Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical Iniversity Kharkiv, Ukraine

Actuality. In spite of the medical immunobiological drug advances in up-to-date medicine the Octaplex 500 IU approved by the treatment of postpartum order issued by the Ministry of hemorrhage remains a serious Health of Ukraine No.197 from challenge for obstetricians. The 05.03.2010 incidence of such bleedings Results of the study: The comprises up to 9-11% of the total treatment of women with profuse number of deliveries. It is blood loss was aimed both at surgical hemorrhage that conditions the arrest of bleeding and at urgent fourth part of the causes of maternal replenishment of circulating blood mortality, of which over 70% result volume. This method is not possible from disorders of hemostatic system, without infusion therapy and i.e. it can be considered a administration of drugs, activating manifestation of DIC-syndrome. The hemostasis and preventing the incidence of profuse obstetric development of coagulopathy. hemorrhage is 0.5 - 4.5% of the total Development of hemorrhagic shock number of bleedings. followed by a severe disruption of The aim was to analyze the blood coagulation system is the most effectiveness of administration of severe and life-threatening therapeutic agent Octaplex in the complication of blood and plasma treatment of profuse obstetric loss. The action of this drug is aimed hemorrhage. at the correction of coagulopathy. It Materials and methods: the contains several coagulation factors Department of Obstetrics, in high concentration: factor II - 220- Gynecology and Children Gynecology 760 IU, Factor VII - 180-480 IU, assessed feasibility of administration Factor IX - 500 IU, Factor X - 360-600 and effectiveness of the therapy with IU, protein S - 140-640 IU, protein C - this drug according to the 140-620 IU, heparin - 100-250 IU. instructions for the employment of Given the amount of clotting factors 197

ISIC-2016 Abstract book it can be said that one bottle of prothrombin - 52.5%, blood clotting Octaplex 500 IU is equivalent to time - 5 minutes 41 seconds). Indices 1000-1500 ml of fresh frozen of blood clotting after administration plasma. The average amount of blood of Octaplex 500 IU (INR-1.12, Quick’s loss was 950 mL (mean prothrombin - 86.3%, blood clotting intraoperative blood loss - 620 ml), time - 7 minutes 23 seconds). which corresponds to an average Conclusion: Octaplex is an value of 21% of CBV, 1.53% of body effective agent for the treatment of weight. Indices of blood clotting profuse postpartum hemorrhage and before administration of Octaplex corrects coagulopathy. 500 IU (INR - 0.78, Quick’s

Praharaj Pooja RELEVANT AND MOST APPROPRIATE CONCEIVING PERIOD FOR A FULL TERM PREGNANCY AFTER MISCARRIAGE Research advisor: Ass.prof. Gayvoronskaya Svetlana Department of gynecology № 2 Kharkiv National Medical University Kharkov, Ukraine

Actuality: A miscarriage is the conceive within 3 cycles of spontaneous loss of a fetus before menstruation to give birth to a live the 20th week of pregnancy. For baby and avoid further loss. There is those who lose a pregnancy in the no physiologic reason for delaying first or second trimester, the pregnancy attempt after a loss, it question is always concerned of somehow depends upon the when to begin trying to conceive emotional and mental status of the again. It can often be associated couple. highly with emotion and uncertainty. The aim : To study the Doctors usually recommend that relevance of conceiving immediately women should wait at least three within 3 months and after 3 months months after a miscarriage before of miscarriage. trying to get pregnant again with the Materials and methods: belief that this delay will reduce the Literal Statistics of Women who risk of another miscarriage. My planned to conceive sooner and later research suggests that the three- after their miscarriage taking into month wait recommendation isn’t account the terms of their age, their warranted and it may lead to another partner’s age, BMI , race, smoking loss. It’s always a better option to history, alcohol use, physical activity, 198

ISIC-2016 Abstract book sub fertility (history of difficulty other 83 women (77%) began trying conceiving over at least a year of to conceive within three months trying), previous children, previous after their loss. Among those who losses, gestational age of previous began trying to conceive within three loss. months, just over half 44 women Results: We tracked 108 (53%) became pregnant and gave women with two previous birth to a live baby. Meanwhile just 9 miscarriages for up to six menstrual women (36%) of those who waited cycles while they tried to conceive at least three months after their loss again. None of the women’s most before trying to conceive could recent pregnancies had resulted in a manage to give birth to a full term live birth or stillbirth or had involved baby. an ectopic or molar pregnancy, and Conclusion: Women who 106 (99%) women had lost their started trying to conceive within fetuses at 19 weeks of pregnancy or three months after their last earlier. Almost 25 women (23%) miscarriage still had approximately waited more than three months after 65% greater chances of becoming their last pregnancy loss before pregnant and giving live birth than attempting to conceive again, but the women who waited.

Shakhzadian Lauritta, Liubomudrova Katerina CRITERIA FOR THE DIAGNOSIS OF SERTOLI - LEYDIG TUMORS Research advisor: Gayvoronskaya Svetlana, assistant professor Department of Obstetrics and Gynecology №2 Kharkiv national medical university, Kharkiv, Ukraine

Actuality: Sertoli - Leydig develops between the ages of 20-40 Tumors (also referred to as years. androblastoma and The aim: To search for the arrhenoblastoma) - are ovarian most effective diagnostic and neoplasias of stromal sex cord- prognostic criteria of ovarian tumors producing testosterone. This from sex cord stromal women of masculinizing hormone producing childbearing age. tumors containing Sertoli cells - Materials and Methods: We Leydig (hilyusnye and stromal cells). observed 5 women aged 25-38 years, These tumors constitute 1.5-2.0% of with a benign course of the disease. all ovarian tumors and usually Everyone developed a similar clinical picture of acne, hirsutism (40% 199

ISIC-2016 Abstract book patients), amenorrhea (60%), was determined by the side of the virilization, infertility, uterus, it was one-sided, mobile, masculinization, lack of libido, and painless, with a diameter of about 15 many showed a decrease of cm, oval, thick consistency, with a subcutaneous fat, hypertrophy of the smooth surface. Ultrasound picture clitoris. showed inhomogeneous internal Laboratory studies yielded the structure with multiple hyperechoic following results: we observed and hypoechoic areas inclusions. women with identified reduction of Ultrasonography of androblastoma FSH - 1.2 mU / l (N = 2.8-11.3mEd / has similar characteristics with l) and LH - 1.4 mU / l (N = 2.0- granulous- and theca cell tumors. All 14.0mEd / liter) in the follicular patients had the surgical removal of phase; androstenedione low content the mass, salpingo-oophorectomy - 60 ng / 100 ml (N = 85-275 ng / with resection of the greater 100 ml) in plasma and a significant omentum and the revision of the increase in testosterone indicators - contralateral ovary. 5.3 pg / ml (N = 0,45 - 3,17 pg / ml). Conclusions. For the purpose An increase in the characteristic α- of differential diagnosis of ovarian fetoprotein - 15Ed / ml (N = <10Ed / tumors, hormonal examination ml), DHEA-S - 500 mg / dL (N = 30- should be carried out to investigate 333 mcg / dl) was observed. In these tumor markers, ultrasonography, CT patients no expression of cytokeratin (if indicated), a suspected Sertoli - 7, smooth muscle actin, CD 10, Leydig tumor requires immediate CA125 was detected. At surgery. gynecological examination the tumor

Skorbach Olena, Kucher Alina METABOLIC IMPLICATIONS IN WOMEN AFTER HYSTERECTOMY Research advisor:Prof. Scsherbina Mykola Department of obstetrics and gynecology №1 Kharkiv National Medical University Kharkov, Ukraine

Actuality . According to the preserving ovarian tissue, 60-85% of literature, hysterectomy is the most women accompanied by neuro- common radical surgery on the vegetative and psycho-emotional internal female organs in women. disorders, changes in lipid and Surgical removal of the uterus, even 200

ISIC-2016 Abstract book protein metabolism and leads to the disturbances in II gr. included development of metabolic syndrome. increase of body weight, blood The aim. The aim of our study pressure, changes in lipid and was to study features of hormonal carbohydrate metabolism. After 1 and metabolic processes in women year in women after hysterectomy after hysterectomy. was ascertained BMI tends to Material and methods. We increase on average by 12%. The examined 60 women aged 40 to 51 same dynamics also noted regarding years. All women were divided into to BP. Before the surgery, 25 (83.3%) the following clinical groups: I gr. – women had normal blood pressure, 30 healthy women; II gr. – 30 women but by the end of the first year after after hysterectomy without removal surgery were observed in 37 (74%) of both ovaries. Assessment of women some increase in systolic hormonal carried in plasma by blood pressure and diastolic blood enzyme immunoassay using test kits pressure less. The study of manufacturing company "Alkor Bio" carbohydrate metabolism did not (St. Petersburg, Russia). All women reveal significant abnormalities of determine the Body Mass Index basal levels of IRI and C-peptide in (BMI), conducted systolic and the women group II. In the analysis diastolic blood pressure (BP). Levels of lipid metabolism in II gr. were able of serum immunoreactive insulin to identify potential increase in (IRI) and C-peptide were determined atherogenic potential of blood, by standard radioimmunoassay kits characterized by firm DRG International Inc (USA) by hypercholesterolaemia and ELISA. Determination of the significantly different from I gr. concentration of total cholesterol, [p<0.05]. Moreover, an increase of triglycerides (TG), high-density proatherogenic factions as LDL, lipoprotein (HDL) were determined which was significantly different by enzymatic colorimetric method in from I gr. [p<0.05]. Also found a the blood serum using test systems significant increase TG in II gr from Roche Diagnostics comparing to the I gr. [p<0.05]. (Switzerland) on an automatic Antiatherogenic fraction biochemical analyzer Cobas 6000 concentration of HDL cholesterol in (module 501). Low-density II gr. was significantly lower than in I lipoprotein (LDL) was calculated by gr. [p<0.05]. formula W.T. Friedewald (1972). Conclusions. Thus, Results. In the study it was hysterectomy, which is made in the found that in II gr. showed significant reproductive age, contributes to increase in the content of follicle- premature ovarian failure, and stimulating and luteinizing further development and metabolic hormones amid falling estradiol, disorders. progesterone [p <0.05]. Metabolic 201

ISIC-2016 Abstract book Soe Thurein, Romanenko A., Adeyemi A. ROLE OF sFlt-1/PlGF RATIO IN THE DIAGNOSIS AND PROGNOSIS OF PREECLAMPSIA Research Advisor: Assistant Saitarly D.P. Department of Obstetrics and Gynelocogy №2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Preeclampsia is one and PlGF. Patients with preeclampsia of the late gestoses, which affects had a significantly increased sFlt- both the mother and the unborn 1/PlGF ratio. In a prospective study child. It begins after 20 week of by Moore, A.G. et al, the sFlt-1/PlGF gestation and presents with ratio of 276 women with suspected hypertension ≥ 140mmHg (systolic) preeclampsia were measured. High or ≥ 90mmHg (diastolic) and levels of sFlt-1/PlGF ratio were proteinuria ≥ 0.3/24hours with or associated with increased risks of without edema. Mechanism of maternal and neonatal preeclampsia is not fully understood complications. PROGNOSIS and but there is growing evidence that PreOS study found that sFlt-1/PlGF factors such as soluble fms-like ratio < 38 will most likely not tyrosine kinase- 1 (sFlt-1) and develop preeclampsia for at least1 placental growth factor (PIGF) has a week, and ratio 38 – 85 has no major role in disease development. definite diagnosis but are highly sFlt-1:PlGF ratio is increased in the likely to develop preeclampsia in 4 serum of women with preeclampsia. weeks. The ratio >85 was associated Aim: The aim is to determine with early onset preeclampsia and the role of sFlt-1/PlGF ratio in ratio>110 was associated with late diagnosis and prognosis of onset preeclampsia or other forms of preeclampsia placental insufficiency. Severely Materials and methods: elevated sFlt-1/PlGF ratio are studies by Verlohren, S. et al (2012). associated with the need to deliver Moore, A.G. et al (2012). PROGNOSIS within 48 hours. and PreOS study Conclusion: sFlt-1/PlGF ratio Results of research: In one can be used as an additional study by Verlohren S. et al, 388 diagnostic tool in preeclampsia. It singleton pregnancies with normal also has a prognostic value. Though pregnancy outcome, 164 with sFlt-1/PlGF ratio is not included in preeclampsia, 36 with gestational current guidelines, its use will help hypertension and 42 with chronic to optimize care in women with hypertension were tested for sFlt-1 preeclampsia.

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ISIC-2016 Abstract book V. Yu. Solyanik, A. M. Chumak CERVICAL POLYP (CLINICAL CASE) Scientific supervisor: Doctor of Medical Science, Professor I. A. Tuchkina Department of Obstetrics, Gynecology and Children Gynecology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Cervical polyps rank female type. The vagina is narrow one of the first disorders among with clean vaginal mucosa. The benign abnormalities as they affect cervix is conical in shape, without 22.8% of gynecological patients and deformations, cervical epithelium is are often found in pregnant women. intact. A polyp of 1.8×0.5 cm in size is Pregnancy promotes active seen in the cervical canal. The body proliferative processes in the cervix, of uterus is increased to 17 weeks of leading to reserve cell proliferation, pregnancy. The adnexa are not microglandular hyperplasia and detectable. Vaginal vault is squamous metaplasia. unobstructed and painless. Simultaneously, cervical polyps show Discharge is spotting and blood- decidual response of stroma. tinged. On examination: complete Pregnant women may have decidual blood count: hemoglobin 125 g /l, pseudopolyps with local decidual RBC 4.1×10/12, WBC 5.0×10/9, changes in cervical stroma, which is thrombocytes 220×10/9, BSR 24 shaped like a protruding plaque or a mm/h, stabs-2%, segmented pseudopolyp. neutrophils-69%, eosinophils - 2%, Clinical case. A pregnant 27- lymphocytes-22%, monocytes - 5%; year-old patient A. was referred to urinalysis: quantity 50.0 mL, color: gynecology department on 03/12/15 light yellow, specific weight 1.010, by a doctor from a maternity welfare alkaline reaction, WBC 10-12 within clinic with blood-tinged discharge sight, transitional epithelium 0-2 from the genital tract. The woman within sight, much mucus. was examined and diagnosed with: Colposcopy: a decidual polyp of pregnancy of 17 weeks and a 1.8×0.5 cm in size seen in the decidual polyp. Present history. At cervical canal. US findings: the first consultation for registration hyperechoic formation of 1.8×0.5 cm she was diagnosed with pregnancy of is visualized in the cavity of the 17 weeks and a decidual polyp. The cervix. woman was referred to hospital for Treatment. Decidual polyps treatment. Gynecologic status. during pregnancy are subject to External genitalia are without immediate removal, if such abnormalities. Body hair is of the symptoms are observed:

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ISIC-2016 Abstract book • The formation bleeds techniques and an endoscope, constantly; followed by thermo- and • The surface of the polyp is cryocautery. The method is found to have ulcerations; minimally invasive and does not • The polyp triggers spasms require scraping of the cervix, so it and increases the tone of the uterus; can be used in pregnancy. In this • The infected polyp undergoes clinical case polypectomy is destructive changes. performed by unscrewing followed Conclusions. Polyps are by histological examination of the removed by unscrewing using laser removed tissue.

V. A. Sorokina, V. V. Grigoryeva, A. K. Dusmatova INCIDENCE AND CHARACTER OF INFLAMMATORY DISEASES IN PREGNANT WOMEN Scientific supervisor: Doctor of Medical Science, Professor I. A. Tuchkina Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Inflammatory and labor records at the Department diseases in pregnant women of Pathologic Pregnancy in Kharkiv complicate pregnancy, triggering Maternity Hospital No.1 during the adverse outcomes of labor and years 2014-2015. deteriorating postpartum period. The study showed that prior to The aim of the study was to the present pregnancy 67% of analyze the incidence and character women had inflammatory diseases of of inflammatory diseases in pregnant the reproductive organs (vaginitis, women. colpitis, endocervicitis, salpingo- Materials and methods. The oophoritis, etc.). Sexually study involved examination of 60 transmitted infections were detected pregnant women at the age of 20-35 in 15.5% of women. years at 25-38 weeks of gestation. All Extragenital diseases in the pregnant women underwent remission were found in 12.2% of clinical examination in accordance pregnant. The most frequently with the order issued by the Ministry observed disorders were chronic of Health of Ukraine No. 582 (of pyelonephritis (25.0%), chronic 15.12.2003). gastritis (15.0%) and vegetative- Results. The study implied vascular dystonia (10.0%). retrospective analysis of obstetric 204

ISIC-2016 Abstract book The study of the reproductive secondary to a decrease in lactic acid function showed that the present bacteria, presence of Gardnerella pregnancy was the first for 30.5% of vaginalis. women, 20.5% of pregnant women Ultrasound examination had more than two abortions, 8.4% revealed oligohydramnios in 20 and 5.4%, respectively, had pregnant (33.3%) and pathologic and premature birth in polyhydramnios in 18 (30%), history, 15.6% of patients had increased echogenicity of the ectopic pregnancy, infertility I was endothelium of the internal organs in observed in10.6% and infertility II in 5 (8.3%), placental dysfunction in 17 9.0%. (28.4%) patients. Clinically pregnant patients Labor history: vaginal labor in presented with itching and burning 34 (56.6%), cesarean section in 17 in the vagina, frequent urination and cases, including: scheduled in 12 vaginal discharge (leukorrhea). (20.0%), urgent in 5 (3.4%), Bacteriologic study of vaginal premature rupture of membranes in contents showed fungus mycelium 9 pregnant women (15.0%). and spores in 28 pregnant women Conclusion: Bacteriologic (46.6%), indicating vaginal study of vaginal content has a high candidiasis. Bacterial vaginosis was diagnostic value in prognosis of identified in 32 pregnant women pregnancy and childbirth. It allows (53.4%): increased white blood cells timely, non-invasively prevention of count from 15 to 45 within sight, abnormal changes in the mother- clue cells and much mucus, placenta-fetus system.

N. A. Stolbova ENDOMETRIAL HYPERPLASIA. TREATMENT AND PREVENTION AT REPRODUCTIVE AGE. Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. A high incidence of of EH identification lies in the fact endometrial hyperplasia (EH) and that it is one of the most frequent the likelihood of malignancy put this causes of uterine bleeding and pathological condition among the women's hospitalization. most urgent problems of modern The aim of our study was to medicine. Crucial clinical significance improve the treatment of women 205

ISIC-2016 Abstract book with endometrial hyperplasia (EH) tablet / day (30 mg) from the 1st day and to determine the effectiveness of of menstrual cycle for 21 days, phytonutrient indole-3-carbinol in munali-30 - "Lupin Limited", a complex treatment. representative office in Ukraine) for Materials and methods. To 1-3 months; the second group achieve this goal we performed a consisted of 25 women who after retrospective study of 50 women of curettage of the uterine cavity were mean age 36.6±2.5 years, who administered COCs for 1-3 months underwent inpatient treatment from and further till 6 months 2014 to 2016 at the Department of phytonutrients "Indole-F" Obstetrics, Gynecology and Children (Farmakom, Kharkov) 1-2 capsules Gynecology of KNMU. Indications for (1 capsule- 90 mg), 2 times a day. hospitalization of patients included Results. In the first clinical uterine bleedings of different nature group E2 indices were not (85.6%) and presence of significantly different before and ultrasonographic findings of after the treatment (before pathological changes of the treatment: 21.5 ± 0.70 ng / ml; after endometrium (14.4%). treatment: 20.1 ± 1.3ng / ml); PRG Echography was regarded as levels tended to increase (before: an EH marker. An increase in the 77.5 ± 8.1 ng / ml; after 96.3 ± 7.2 ng thickness of more than 16 mm / ml). In the second clinical group E2 and/or ultrasound signs of abnormal levels decreased (before: 26.2 ± 1.1 changes in its structure were ng / ml; after: 19.6 ± 1.1 ng / ml), considered to be one of the criteria of and PRG levels increases (before: endometrial hyperplasia. The 75.2 ± 5.4 ng / ml; after: 91.8 ± 2.7 ng abovementioned signs were / ml). indications for morphological The study of findings in 6 examination after therapeutic and months showed that EH relapses in diagnostic curettage of the uterus. the second group was observed 3 Prior to and after the treatment (in 3 times less than in the first group 1 and 6 months) all women underwent (12% vs. 32%) tests to determine their hormonal Conclusion. The study showed profile (estradiol (E2) and that administration of progesterone (PRG)). The patients phytonutrients as part of were divided into two clinical comprehensive therapy of patients groups: the first group - 25 women, with EH improves the effectiveness who after curettage of the uterine of treatment and reduces the cavity received combined oral incidence of recurrence in women of contraceptives (COCs) reproductive age. (ethinylestradiol + desogestrel 1

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ISIC-2016 Abstract book Yu. A. Svidchenko, E. A. Kamardina, V. A. Miroshnikova PROLONGED CONTRACEPTION STRATEGIES IN THE TREATMENT OF GENITAL ENDOMETRIOSIS Research advisor: Tuchkina Irina, Doctor of Medical Science, Professor Department of Obstetrics, Gynecology and Children Gynecology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The problem of women were examined by clinical, endometriosis remains one of the laboratory and instrumental most difficult in present-date methods, according to the order gynecology. The incidence of this issued by the Ministry of Health of pathology is high and stable Ukraine No.626 (of 08.10.2007). comprising 5-10% of all Results. The study found that reproductive age women and 20- administration of ""Jeanine"" 30% of women with primary and resulted in a significant reduction in secondary infertility, and has no the severity of dysmenorrhea - 40 tendency to decrease. women (76.9%), dyspareunia - 45 The aim. To evaluate the women (88.8%). It also identified an efficacy of prolonged combination increase in the quality of life and the oral contraceptives in the treatment degree of sexual satisfaction in of genital endometriosis. patients. Ultrasound examination Materials and methods. The showed that 38 women (73%) had a study involved examination of 52 clear tendency towards a decrease in case histories of women with genital the severity of genital endometriosis endometriosis. Of these, 27 patients and a reduction in size of were diagnosed with endometriosis endometrioid heterotopias during of the uterus and endometriosis of the course of treatment. Side effects the vagina, who took ""Jeanine"" as of the drug were observed in 10 an independent method of treatment patients (19%) - spotting blood- (63 days of receiving active pills tinged discharge in the first three followed by a seven-day break), and months of drug administration. 25 women with endometriosis of the Conclusion. The study ovaries, endometriosis of the uterus, revealed positive dynamics in the who took ""Jeanine"" after surgical course of treatment by ""Jeanine"", treatment (coagulation of both as an independent endometriosis foci during monomethod and as an anti- laparoscopy). The average age of recurrence postoperative therapy. patients was 33.2±0.7 years. The

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ISIC-2016 Abstract book Adejobi Fisayo, Nwaizu Tochukwu, Naguta L.A. EFFECT OF PHYTOESTROGENS IN PATIENTS WITH ABNORMAL UTERINE BLEEDING Department of Obstetrics and Gynecology №1, Head of the Department prof. M.O. SHCHERBYNA Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: In the pathogenesis histological and ultrasound of abnormal uterine bleeding (AUB) examinations were taken into the main role is give to the violation consideration. We had the of the relationship between the comparative analysis of the AUB hypothalamus, pituitary, ovaries and treatment: 31 patients who received uterus, resulting in the change of the traditional treatment, which processes of follikulogenesis, included hemostatic and hormone ovulation, formation and therapy (comparative group) and 28 development of the corpus luteum, patients treated with combined and, consequently, this leads to the therapy, which included the use of disruption of processes of phytoestrogens. The control group proliferation, secretion and consisted of 12 healthy women. All endometrium desquamation. AUB patients had complaints of general frequency ranges from 15 to 20%. weakness, fatigue, menstrual AUB can be not only manifestations disorders. of pathological processes in the The results. The average age reproductive system, but the first of women was 31,8 ± 1,53 years with sign of violations of hemostasis individual ranges from 22 to 48 fundamental units, as well. years. In the analysis of menstrual The aim. To examine the function it has been revealed that the feasibility of phytoestrogen therapy average age of menarche was 13,71 ± in the treatment of AUB to reduce 1,4 years. Full normalization of this pathology in women of menstrual function was noted in 26 reproductive age. (92.8%) patients of the main group, Materials and methods. To compared with 28 women (90.3%) achieve this goal, we have studied from the comparison group. In the the effectiveness of use of phytoestrogens a positive phytoestrogenotherapy in treatment trend has been noticed, confirmed by of patients with AUB. When making clinical and laboratory, hormone, the diagnosis, complaints of patients, histological and ultrasound studies. menstrual function, clinical and All patients of the main group have laboratory techniques, tests of significantly improved their overall functional diagnostics, hormone, health conditions, there were no

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ISIC-2016 Abstract book complaints, menstrual blood loss Conclusion. Thus, the received decreased. 2 (6.4%) patients from data, the positive dynamics of clinical the comparison group required symptoms and absence of recurrence discontinuation of hormone therapy in patients who used phytoestrogens, due to side effects. All patients whose show the effectiveness of the therapy treatment was conducted with the and it can be recommended for use of phytoestrogens underwent widespread use in gynecological ultrasound examination 6 months practice. later and endometrial pathology was not found.

Tykhanskyi D., Liubomudrova K.S., Melashych Jane TREАTMENT OF BACTERIAL VAGINOSIS WITH MONOCHROMATIC RED LIGHT Research advisor - Associate Professor Gayvoronskaya S. Department of Obstetrics and Gynecology No. 2, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Light of helium- with simultaneously using of neon laser has an influence on «Mustang-2000» device – 7 processes in tissues during procedures. In control group (15 metabolism shifts. Vaginal women) were used analogical drugs dysbacteriosis is a structural with successive topical disturbance of mucosa’s biofilm. administration of lactobacterise. Collective immunity of pathological Effectiveness of therapy was biofilm prevents from correction of assessed according to the character bacterial vaginosis (BV) with of BV’s intensity before and after the probiotics. treatment as the data shows: The aim. To investigate presence or absence and quantity of influence of lasers’ radiation on biofilms; quantitative assessment of character of pathological vaginal anaerobes to aerobes, detected after biofilms at often recurrent vaginal treatment; lysozyme’s level of dysbiosis. vaginal biotope. Material and methods. Results: Patients with BV in Experimental group (40 women with 72.5% (n=29) of cases had biofilms BV) passed a treatment course of BV: in the experimental group and 73.3% metronidazole 500 mg orally twice a (n=11) in the control group. day for 5–7 days and clindamycin Correlation of anaerobes to aerobes 100 mg intravaginally for 6 days in experimental group was 153:1, in 209

ISIC-2016 Abstract book control group – 156:1. Contents of vaginal secretion of experimental lysozyme in secretion before group was according to the treatment was 39,74±6,25 mcg/l physiological norm (30,87±5,15 (cervical secretion) at the rate mcg/l and 28,89± 6,29 mcg/l 30,54±6,32 mcg/l, р<0,05 and accordingly). Lysozyme’s contents in 37,97±8,52 mcg/l (vaginal slime) at secretion in control group remained the rate 28,85±6,94 mcg/l. After increased 37,96±5,7 mcg/l with the treatment’s course, clinical recovery norm of 30,54±6,32, р<0,05 in occurred in 87,5% (n=35) of cases in cervical slime and 33,79±6,8 mcg/l experimental group and in 60% when the norm is 28,85±6,94 mcg/l, (n=9) of cases in control group. р<0,05 in vaginal contents. Presence of biofilms in experimental Conclusions: Using of group regressed to 22,5% (n=9) and monochromatic red light leads to correlation’s quantitation of stimulation of local immunity cells, anaerobes to aerobes changed to 4:1. which regenerate and revive In control group presence of adaptive mechanisms. Thanks to biofilm’s associations was detected these pathological biofilm in 80% (n=12), correlation of associations are destroyed and anaerobes to aerobes was 40:1. recovery is accelerated. Lysozyme’s contents in cervical and

Yavdak Anastasia SPECIFIC FEATURES OF UTERINE SCAR FORMATION AFTER CESAREAN SECTION Research supervisor:Prof. Scsherbina Irina Department of obstetrics and gynecology №1 Kharkiv National Medical University Kharkov, Ukraine

Actuality: The most important abdominal delivery creates a new strategic direction for Social Policy of problem - the management of Ukraine is to preserve and pregnancy and delivery in women strengthen the health of the with a uterine scar. In currently have population. Prevailing trends in a scar on the uterus up to 10 % society - low fertility, ecological multiparous. Traditional evaluation trouble, determine characteristics of of the uterine scar during pregnancy, modern obstetrics - a significant based mainly on the analysis of increase in the frequency of clinical and anamnestic data, is not abdominal delivery. However, highly informative, the conclusion of increasing the frequency of sonographic study is ambiguous. For 210

ISIC-2016 Abstract book morphological study of tissue of the The average age of patients uterine scar biopsy is mainly used at was 27 to 5 years. In the somatic re-operation. However, until our history of the patients of the 1 group time are unclear factors that predominated diseases of the determine complete wound healing circulatory system (mitral valve after surgery. According to the prolaps , dystonia, hypertension), literature increasingly important in myopia in 27.5 % of patients. The the formation of a defective scar analysis of MMP -9 expression given to the disorganization of the showed an increase in MMP -9, while connective tissue. In connection with in group 1 maximum expression was this search for predictors of significantly higher than in formation of high-grade scar is comparison group. Thus, magnesium relevant. deficiency leads to increased of MMP The aim: Increase the activity and as a consequence, efficiency of diagnostic usefulness of enhance the processes of uterine scar formation on the basis degradation of extracellular matrix - of a clinico - pathogenetic and interstitial connective bases muscle biochemical criteria. tissue of the uterus. Materials and methods: Conclusions: Activity of MMP-9 in the serum was 1. The most important clinical determined with using a fluorescent predictors of inferiority of uterine substrate, magnesium levels - scar are phenotypic signs of colorimetric method with xylidine connective tissue dysplasia. blue. 2. Molecular-biological factors Results: The study included 20 that determine the formation of pregnant women with a uterine scar defective uterine scar are after cesarean section which were hypomagnesemia and increased divided into 2 clinical groups. Group activity of matrix metalloproteinases. 1 - 10 patients with phenotypic traits 3. Clarification of the of undifferentiated connective tissue pathogenesis of formation of dysplasia (NDCTD) and group 2 -10 defective uterine scar can improve pregnant women without signs of the efficiency of diagnosis and to NDCTD. identify ways of prevention

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ISIC-2016 Abstract book

PEDIATRICS

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ISIC-2016 Abstract book Asuka Emediong S, Aliejim Uchenna S. INDICES OF IMMUNE SYSTEM OF JUVENILE IDIOPATHIC ARTHRITIS PATIENTS WITH DIFFERENT COMBINATIONS OF GENOTYPES OF METHYLENETETRAHYDROFOLATE REDUCTASE, METHYLTRANSFERASE, METHYLTRANSFERASE REDUCTASE. Research advisor: Golovko T. Department of Pediatrics V.N. Karazin National University Kharkiv Ukraine.

Actuality. Juvenile Idiopathic variants (MTHFR-677 and MTHFR Arthritis (JIA) - autoimmune, non- 129). infectious chronic inflammatory joint Method: the index group disease in children less than 16 years compiled 9 patients with JIA, control of age. Methotrexate (MTX) is one of group compiled 20 apparently the most effective medication for healthy children. Children of index treating of patient with JIA, but long- group were divided into 3 groups. term therapy by MTX leads to The first group had none or one disturbances of folate cycle. The 5- affected gene, the second group had methyltetrahydrofolate- two, while the third had three and homocysteine methyltransferase more affected genes. Blood analysis (MTR), 5-methyltetrahydrofolate- indices included: total hemolytic homocysteine methyltransferase complement assay, circulating reductase (MTRR), 5,10 immune complex (CIC), circulating methylenetetrahydrofolate immune complex constant (CIC reductase C677T and A1298C const), immunoglobulin (IgA,G,M). variants (MTHFR-677 and MTHFR MTR, MTRR, MTHFR-677 and 129) are genes which codes enzymes MTHFR 129 were tested by of folate cycle. polymerase chain reaction (PCR). The aim was to determine Statgraphics 3.0 test were used for differences in parameters of immune processing of the data. system of patients with Juvenile Result: the indexes of total Idiopathic Arthritis (JIA) with hemolytic complement assay in first different combinations of genotype and second groups were without of 5-methyltetrahydrofolate- significant difference in comparison homocysteine methyltransferase with indices of control group. but in (MTR), 5-methyltetrahydrofolate- patient from III group these homocysteine methyltransferase parameter was authentically higher reductase (MTRR), 5,10 (1,39±0,31, p<0,001, control group methylenetetrahydrofolate 1,14±0,02).The levels of CIC and CIC reductase C677T and A1298C constant were no different from

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ISIC-2016 Abstract book analogous indices of control group. Conclusion: the study shows IgG had an upward trend in patients that the group with three and more of the 3rd group (III group affected genes o had the highest level 17,08±2,45, p<0,05, control group of immune reactivity as compared to 11,66±0,73) and a downward trend patients with two, one or none in patients of the first group. IgM affected genes. Consequently, this were authentically higher in patients requires further studies and from III group 3,08±0,90, p<0,001, investigation on how the degree of control group 1,23±0,09).Patient of immune reactivity corresponds with the 2nd group had a downward genes mutations. trend of IgA , (II group 1,61±0,08, p<0,05, control group 1,88±0).

Awofolaju T.T., Adeleke A. LABORATORY BLOOD PARAMETERS OF JUVENILE IDIOPATHIC ARTHRITIS PATIENTS WITH DIFFERENT COMBINATIONS OF GENOTYPES OF METHYLENETETRAHYDROFOLATE REDUCTASE, METHIONINE SYNTHASE, METHIONINE SYNTHASE AND REDUCTASE GENES Research advisor: Golovko T.A., PhD Pediatrics department, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Actuality. The methyl cycle Materials and methods: the play important role in the study included 9 patients with JIA. metabolism of the cytotoxic drug They were divided into 3 groups. The methotrexate. It contains different first group had none or one affected gene coding enzymes, such as the gene, the second group had two, methylenetetrahydrofolate while the third had three and more reductase, methionine synthase, affected genes. The following indexes methionine synthase and reductase. were assessed in the blood: The aim to determine erythrocytes (RBC), hemoglobin differences in laboratory blood (Hb), leukocytes (WBC) with their parameters of patients with Juvenile subtypes, erythrocyte sedimentation Idiopathic Arthritis (JIA) with rate (ESR), glycoproteins, sialic acids, different combinations of genotype seromucoids. Statgraphics 3.0 test of methionine synthase (MTR), were used for processing of the data. methionine synthase and reductase Results: the indexes of (MTRR), methylenetetrahydrofolate erythrocytes and hemoglobin were reductase ( MTHFR 1298 and without significant difference (RBC I MTHFR 677) genes. group 4,25±0,14, p>0,1, II group 214

ISIC-2016 Abstract book 4,13±0,13, p>0,1, III group group 184,50±5,50, p>0,1, II group 3,96±0,16, p>0,1; Hb I group 186,20±9,79, p>0,1, III group 121,50±5,50, p>0,1, II group 204,00±96,00, p>0,1). The 121,20±4,05, p>0,1, III group seromucoids in patients from I and II 113,50±8,50, p>0,1). The level of groups were authentically higher (I WBC was authentically higher in group 0,198±0,088, p<0,05 opposite patients from III group (WBC III II group 0,102±0,004, p<0,05), in group 14,5±5,60, p<0,05 opposite I patients from III group registered group 7,80±1,30, p>0,1, II group the tendency for elevation of 6,69±0,78, p>0,1), though their seromucoid’s level (0,193±0,087, subtypes were without significant p<0,1). difference. In children from III group Conclusions: consequently, registered the tendency for the laboratory blood parameters in elevation of ESR (ESR III group patients with Juvenile Idiopathic 15,5±13,50, p<0,1 opposite I group Arthritis (JIA) from different groups 4,50±0,50, p>0,1, II group 7,00±2,14, were shift multivalued. In patients p>0,1). The biochemical values were with three and more affected genes shift multivalued. For example, were authentically higher WBC and glycoproteins, haptoglobin and sialic registered the tendency for acids were without significant elevation of ESR. In children, who difference (glycoproteins I group had none or one affected gene and 0,350±0,090, p>0,1, II group with two affected genes, were 0,294±0,030, p>0,1, III group authentically higher level of 0,325±0,070, p>0,1; haptoglobin I seromucoids, which indicated the group 1,227±0,496, p>0,1, II group inflammation process of connective 0,822±0,152, p>0,1, III group tissue in this patient. 1,733±0,818, p>0,1; sialic acids I

Mousa Khalil Bahja, Zeinab Hammound RISK FACTORS IN MAXILLARY SINUSITIS ESTIMATED BY CONE BEAM COMPUTED TOMOGRAPHY Research advisor: Fomenko Yulia, Golik Natalya

Maxillary sinusitis of odontogenic dentoalveolar unit . Failure to origin is a well-known condition in accurately identify a dental cause in both the dental and otolaryngology these patients usually lead to communities. It occurs when the persistent symptomatology and schneiderian membrane is violated failure of medical and surgical by conditions arising from therapies directed toward sinusitis. 215

ISIC-2016 Abstract book Unilateral recalcitrant disease and peculiarities of maxillary associated with foul smelling posterior teeth : drainage is a most common feature 1- Anatomy of odontogenic sinusitis . Recently , 2- Presence or absence of endodontic maxillary sinusitis is well identified treatment by the Cone Beam Computed 3- Presence of complications of Tomography (CBCT) that provides endodontic treatment high-quality, accurate three- 4- Changes in maxillary sinusitis dimensional (3D) representations of 5- Presence of foreign bodies related the osseous elements of the to iatrogenic activities. maxillofacial skeleton. CBCT systems Results : 35 of cases revealed are available that provide small field changes in maxillary sinus , 95% of of view images at low dose with cases suffering from maxillary sufficient spatial resolution for sinusitis due to bad endodontic applications in endodontic diagnosis, treatment . Almost 90% of cases treatment guidance, and showed that the roots of the teeth posttreatment evaluation.In recent were in contact or almost publications , patients suffering from penetrating beneath schneiderian maxillary sinusitis increased from membrane . Moreover , 8% of the 10-12% up to 30-40% . cases presented foreign bodies in the Aim of the study : to estimate investigated zones. the relation between the anatomy of Conclusion : Incidence of the upper posterior teeth and odontogenic sinusitis is likely to be maxillary sinusitis and factors that reported due to iatrogenia ( bad increases the risk of sinusitis. endodontic techniques of treatment ) Methodology : 42 patients and peculiarities of the anatomy of suffering from dental problems in the roots. In addition, dental maxillary posterior area , were evaluations with only panoramic or investigated and examined by Cone dental radiographs frequently fail to Beam Computed Tomography diagnose a dental disease in patients (CBCT) (3D ) images during april with odontogenic maxillary sinusitis , 2015 in pediatric therapeutic therefore, should prompt strong dentistry department of KMNU by consideration of a sinus CT or CVCT using the 3D program technology. with thorough inspection. The study was conducted by investigating different parameters

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ISIC-2016 Abstract book Chernenko L.N. STATE OF THE LEFT VENTRICULAR FUNCTION IN CHILDREN WITH BRONCHOPULMONARY DYSPLASIA Research advisor – Professor Gonchar M. Department of Pediatrics No.1 and Neonatology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. With the Results: in the study of development of the technologies in diastolic function of the heart in special care nursery and respiratory children surveyed were analyzed support of premature newborns maximum speed peak early (E), the there has been noted a reduction in maximum speed of atrial systole (A), mortality along with an increase in the ratio (E/A), deceleration time of frequency of bronchopulmonary E peak time and isovolumetric dysplasia (BPD) in children. Today reduction (IVRT). In the first year of we know that children with diseases life in children with BPD of the respiratory system on a par isovolumetric relaxation time was with the overload of the right significantly less than standard ventricle of the heart activity indicators and IVRT in children and changes occur in diastole left the comparison group (p<0.01). chambers of the heart. Diastolic Accelerated isovolumetric relaxation dysfunction is often preceded by correlated with a high heart rate, reducing the pumping function and characteristic of children with BPD can lead to the formation of left (r=0,675, p<0.01). Maximum velocity ventricular heart failure in children of early filling (peak E) was with respiratory diseases. significantly decreased compared The aim of the work was to with normal (p<0.01). While the rate improve the diagnosis of diastolic of atrial contraction tended to dysfunction of the ventricles of the decrease. The median ratio E/A was heart in children with higher than unity (1.29 units). And bronchopulmonary dysplasia. the results of the study E/A in the comparison group (p<0.01). Thus, in Material and methods: the children with BPD in the first year of study involved 83 children aged from life is more likely pseudonormal type 1 month to 3 years with of diastolic dysfunction as type of bronchopulmonary dysplasia. diastolic dysfunction with chronic Assessment of diastolic function and energy deficiency, hypoxia and measurement of pulmonary artery cardiac morphological changes pressure was carried out with the characteristic of patients with BPD. help of all surveyed In 1/3 patients had impaired Dopplerechocardiography «AU 3 relaxation spectrum of the left Partner». 217

ISIC-2016 Abstract book ventricle, indicating that the early Conclusions: for children with stage of diastolic dysfunction. In bronchopulmonary dysplasia these patients the peak E was characterized pseudonormal type of reduced, the peak A and DT - diastolic dysfunction (p<0.01) and a increased against the background of violation of relaxation (p<0.01). Most overtime isovolumetric relaxation. often in children with Infants with BPD frequently detected bronchopulmonary dysplasia in type pseudonormal transmitral mitral spectrum detected diastolic range (p<0.01). pseudonormal type (p<0.01).

Dryl I., Mechanina D. FEATURES OF MICROBIAL-INFLAMMATORY DISEASES IN INFANT CHILDREN Research advisor: Gonchar M., Doctor of Medical Science Department of pediatrics #1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. The numerous period of pyelonephritis, children studies show the relevance of divided into 3 groups: I group 26 studying blood parameters in children with chronic pyelonephritis children with renal insufficiency. Not in the period of remission, the enough described the changes of average duration of disease 5,2 ± indicators of blood test in children 4,02 years; II group of 13 children with kidney disease, that determined with acute exacerbation of chronic by hematology analyzer, including pyelonephritis, duration 2,6 ± 2,05 the average content of hemoglobin years; III group of 15 children with (MCH). acute active pyelonephritis, duration The aim to analyze the blood of disease 5,3 ± 4,4 days. test indicators obtained by Results: mild anemia was found hematology analyzer in children in in 20 (37,03 ± 6,6%) children, 6 of different periods of clinical course of them (23,8 ± 8,4%) - from I group, 7 pyelonephritis. (53,8 ± 14,3%) - from II group, 7 Materials and methods: the (46,6 ± 13,3%) - from III group. The study involved 54 children from 1 to average volume of red blood cells 17 years of age (meanage 6,6 ± 4,3r was reduced in 24 (44,4 ± 6,8%) .). The girls prevailed 44 (81,5 ± children, most often in children III gr. 5,3%) against 10 boys (18,5 ± 5,3%). (53,3 ± 13,3). MCH decreased in 39 In depending on the course of the (72,2 ± 6,15%) children, most often

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ISIC-2016 Abstract book in children II gr. The average volume especially in the acute process and of platelets was reduced in 11 (20,3 the presence of active inflammation. ± 5,5%) children, more often in The MCH reducing in the vast children with III gr. -6 (40,0 ± majority of children 72,2 ± 6,15%, 13,0%). which enables us to regard this Conclusions: one-third of figure as an early manifestation of children with pyelonephritis has anemia (before reduction microcytic hypochromic anemia, hemoglobin).

Dryl I., Kazaryan V., Medyk E. FEATURES OF MICROBIAL-INFLAMMATORY DISEASES IN INFANT CHILDREN Research advisor: Gonchar M., Doctor of Medical Science Department of pediatrics #1, Kharkiv National Medical Iniversity, Kharkiv, Ukraine the ground for hospitalization. 54,1 ± Actuality. The most common 10 % of children were born from the pathological conditions of the first pregnancy; 20,8 ± 10,3 % - from urogenital system in young children the second pregnancy, 25 ± 9,0 % include microbial-inflammatory from the third pregnancy. In 65,2 ± processes in the kidneys. The 10,0 % of children had complications studying of factors that potentially in the anamnesis: in 73,3 ± 11,8 % of affect their appearance and mothers had the threatened contribute to the progression of miscarriage, 26,6 ± 11,8 % of kidney disease is important. mothers suffering from anemia in The aim to identify potentially late terms of the pregnancy. As a unfavorable premorbid background result of the pathological pregnancy, and their impact on the microbial 37,5 ± 10,0 % of children were born and inflammatory process in the by the cesarean section. All children kidneys of infant children. were born full-term with an average Materials and methods: the body mass 3470 ± 300 g. Only ½ of study involved 24 infant children patients had the full breastfeeding (from 2 to 36 months) with acute for more than 6 months whose active pyelonephritis. The average average duration was 3,5 ± 7,5 age of studied patients was 15,5 ± 6,5 months. The duration of the months, girls were prevailed (87,5 ± breastfeeding less than 3 months 6,8 %). was 25 ± 9,0 % of children, that form Results: in 66,6 ± 9,8 % of 50% of the recommended minimum children microbial-inflammatory term and continued 2,4 ± 1,5 months. process in the kidneys debuted with The course of pyelonephritis in 45,8 hyperthermal syndrome, which was ± 10,3 % of children accompanied by 219

ISIC-2016 Abstract book the hypochromic, microcytic mild indicates the greater severity of the anemia severity. All children with the inflammatory activity in these anemia had insufficient duration of patients. breastfeeding, which certainly Conclusions: potentially contributed to the slow process of adverse factors in infant children recovery of the child with include burdened perinatal history in peculiarities of the immune status. the form of long-term existence of Children with the normal duration of the threatened miscarriage and breastfeeding had moderate signs of mothers’ anemia; insufficient inflammation of the slight increase in duration of the breastfeeding and the the erythrocyte sedimentation rate, presence of patients’ mild anemia. 7,8 ± 3,1 mm/hour on average, These factors likely contributed to children with the shorter the emergence of infectious- breastfeeding were more inflammatory process with higher pronounced signs of inflammation level of activity compared to children with increased sedimentation rate to with the adequate breastfeeding 20,7 ± 5,4 on average. The last one without anemia.

Gordyeyeva A.A., Plohinov G.A., Zabolotnaya N.I. CHEST WALL DEFORMATION AS ONE OF MANIFESTATIONS OF CONNECTIVE TISSUE DYSPLASIA Research Advisor: Professor, DM Mokiya-Serbina S.A. Department of Pediatrics, Family Medicine and Clinical Laboratory Diagnostics State Establishment “Dnipropetrovsk Medical Academy” Dnipropetrovsk, Ukraine The materials and methods: Actuality. Chest wall we studied 269 children aged deformations are divided into between 6 to 14 years, pupils of congenital and acquired. According school №. 45 of Krivoy Rog. to various authors, these deformities Results: we identified 68 occur in 4% of the population and (25,28%) children with chest wall more often is combined with deformities, funnel chest wasin 53 manifestations of connective tissue (78%) children and keel chest – in 15 dysplasia (CTD). children (22%). 35 (51.5%) children The aim of the work is to with manifestations of mild investigate the frequency of chest connective tissue dysplasia (normal wall deformities in children of 6-14 variant) had chest deformity, while years with various degree of in 30 cases (44.1%) it was funnel connective tissue dysplasia. chest, in 5 (7,4%) – keel chest. One 220

ISIC-2016 Abstract book third of children with chest wall maxillofacial area, bone-articular deformities (21; 30,9%) were found system met with reliably the same to have phenotypic signs of CTD of frequency with these deformities, moderate degree, while funnel chest but keel chest was more often was diagnosed in 15 (22.1%), and combined with scoliosis of 2 degree. keel chest in 5 cases (7.4%). CTD of Conclusions: the dependence of the heavy degree was diagnosed in 12 occurrence frequency of chest wall (17,6%) children with chest wall deformity of the severity of deformity, funnel chest occurred in 8 connective tissue dysplasia was (11.8%) children, keel chest – in 4 established. The presence of chest (5,9%) children. Among examined wall deformities with mild CTD pupils with funnel chest boys met (normal variant) in almost half of the twice as often than girls, children probably indicates the Comparative evaluation of acquired nature of the disease. In occurrence frequency of individual children of 6-14 years, irrespective phenotypic features in funnel and of the severity of CTD funnel chest keel chest showed that dominated. manifestations of CTD of the skin,

Gupta Anmol BREASTFEEDING IN KHARKIV, CAN WE IMPROVE SITUATION? Research advisor: Barska L., Candidate of Medical Science Department of Propedeutics of Pediatrics, Kharkiv National Medical Iniversity, Kharkiv, Ukraine children are failing to receive the full Actuality. The Benefits of benefits provided by breastfeeding. breastfeeding are evident and were Why according to WHO published worldwide. The Concept statistics the prevalence of breast- Baby Friendly hospital was accepted feeding up to 6 months is only 20% in the world and was distributed in in Ukraine? First of all, Ukrainian our country. The Lancet journal publications during the last 5-10 turned to this topic in February years show few studies about the 2016. It was written that just 1 in 5 prevalence of breastfeeding, as well children in high-income countries as researches which are devoted to are breastfed to 12 months, whilst the promotion of breastfeeding. By only 1 in 3 children in low and the way foreign sources, including middle-income countries are the human Lactation Journal exclusively breastfed for the first 6 demonstrate hundreds of months. As a result, millions of publications and this number grows every year. 221

ISIC-2016 Abstract book According to the data of Kiev breastfeeding were: milk lack- 50% Breastfeeding Monitoring Centre, it families, by the way inadequate was revealed that 46.5% women had weight gain during breastfeeding problems with breastfeeding after observed only 5% women, painful discharge from the maternity ward. nipples - 45% women. Formula More often there were problems feeding was obtained by 85% of with nipples pain, lactostasis, as well children during their first days of life. as the lack of mother's milk. Only 20% women were asked for The aim: To investigate the medical help in case of breastfeeding prevalence of breastfeeding among problems. And 80% of women the children of our region, to find out decided to give formula for a first which factors lead to early finishing time on their own. Those women of breastfeeding. who asked for help in 50% returned Materials and Methods: We to exclusive breastfeeding. have interviewed 52 mothers of Conclusions: Distribution of children which were treated at the high-quality and adequate Multidisciplinary Clinical Hospital information devoted to No.17 in Kharkiv for various reason. breastfeeding among women by Age of children ranged from 1.5 physicians will increase the months to 22 months. The prevalence of breastfeeding in our prevalence of breast-feeding in country. Increased breastfeeding children averaged 50%, up to 6 rate in our country can raise not only months breast milk was obtained by the level of the nation's health, but 35% children. About 99% of children also will effect on the economic were breastfed during first hours. status of the citizens. There is the The average breastfeeding duration high probability to return was 2.0-4.5 months. breastfeeding in case of adequate Results: The reasons that lactation help. leaded to the early finish of

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ISIC-2016 Abstract book Isa Mashkur Abdulhamid, Patel Priyanka Harishchanka, Uliana Ivanivna Marusyk THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL-AGE CHILDREN WITH SEVERE ASTHMA Bukovinian State Medical University ({Department of pediatrics and children’s infectious diseases}, Chernivtsi, Ukraine)

Introduction: A major study atopy, standard household, challenge among modern pediatric epidermal, pollen and food allergen allergic diseases is bronchial asthma. was used. Assigning asthma control therapy to Clinical and epidemiological children should be considered based risks, as well as the diagnostic value on the phenotype. Hence, of individual indicators of atopic performance of atopic reactivity in reactivity for severe asthma children that reflect the specific phenotype verification were defined. pathogenic mechanisms of asthma Results: About one in three will personalize treatment and thus patients (36.4%) with the phenotype improve management of asthma. of severe asthma recorded Aim: To increase the significantly increased content of IL- effectiveness of treatment of severe 4 (more than 10.0 pg/ml), while only asthma phenotype in school-age 15.5% in the second group children, taking into account the (Рφ<0.05). There was increased risk diagnostic value of atopic reactivity of relatively raised content of IL-4 indicators. and IL-5 in serum of patients with Materials and method: 60 severe asthma. Almost every second school-age children suffering from child suffering from severe asthma asthma were comprehensively noted increased concentration of IgE examined in the pulmonology (>545.3 IU/ml). There were department of Chernivtsi Regional significantly more frequent cases of Children's Clinical Hospital. The hypersensitivity to household study involved 30 pupils with severe allergens in the group of patients asthma and 30 children with with severe asthma. Thus, a moderate course. The content of hyperaemia of more than 15.0mm serum total immunoglobulin E(IgE), was recorded in 81.5% of children of IL-4 and IL-5 were determined by the first group and only in 51.9% enzyme-linked immunosorbent (Pφ<0.05) of the second. assay (ELISA). Determination of Conclusion: The phenotype of immediate type skin sensitivity to severe asthma raises the risk of nonbacterial standard allergens was increased content of IL-4 and IL -5 in performed by intradermal tests. To serum by 3.1 times. However, this 223

ISIC-2016 Abstract book paraclinical test is rather suitable for chances of severe asthma being verification of this phenotype (Sp – present. Increased sensitivity to 84.6% (95% CI 75.9-91.1)) than for domestic allergens (hyperemia more its detection (Se – 36.4% (95% CI than 15.0mm) allows severe asthma 26.9-46.6)). Concentration of total specificity verification (81.5%) and IgE in serum of more than 545.3 personalization of treatment policy IU/ml in children doubles the in these patients.

Koval V. DIFFERENTIAL DIAGNOSIS OF TROMBOCYTOSIS IN CHILDREN BASED ON CLINICAL EXPERIENCE Research Advisor: PhD, Associate Professor Ishchenko T.B. Department of Pediatrics №1 and Neonatology Kharkiv National Medical University Kharkiv, Ukraine body length of 44 cm, Apgar score of Actuality. The most common 3-4 points. Condition was very reason of thrombocytosis is a severe and resuscitation with non- secondary or reactive process, invasive respiratory support was caused by infection, trauma, held. Since birth the neonate had operation, anemia, congenital severe respiratory and neurological adrenal hyperplasia, medications disorders, then hemorrhagic and (corticoids, sympathomimetics) and hepatolienal syndrome appeared. In other reasons. Primary clinical blood tests there was anemia, thrombocytosis (family leukopenia, thrombocytosis (up to thrombocytosis, megakaryocytic 1300×109), distinct myeloid leukemia) caused by clonal irritation. Congenital megakaryocytic proliferation of bone marrow is leukemia was supposed. But about 10% of cases. There are myelogram was not held due to principal differences between the severe condition. In spite of intensive primary and secondary therapy the infant died at 9 days of thrombocytosis in etiopathogenesis life. Results of autopsy confirmed and clinical manifestations, but often primary thrombocytosis due to it is difficult to differentiate these congenital megakaryocytic leukemia. types basing on clinical symptoms A boy was born from 4th and laboratory data. pregnancy 2nd delivery in the Results: a boy was born from gestational age of 40 weeks, cesarean the 5th pregnancy, 2nd premature section with birth weight of 3500g, delivery in gestational age of 32 body length of 51 cm, Apgar score of weeks with body weight of 2240 g, 8-9. Hyperpigmentation of genitals 224

ISIC-2016 Abstract book was observed. Condition observed. In this case there was a deteriorated in the first weeks of life, secondary thrombocytosis when anxiety, flacidity, repeated associated with the underlying vomiting, refusal to eat, loss of body disease in combination with weight appeared. Basing on microbial infection processes on the complaints, electrolyte and hormonal background of immunodeficiency. disorders congenital adrenal Conclusions: in the case of a hyperplasia, salt-wasting form was transient thrombocytosis, which diagnosed. In a clinical blood test disappear after treatment of there was high thrombocytosis (up background cause, heamotological to 800×109), granulocyte shift, examination is not necessary. In anemia. Child received substitution cases of combined reasons of corticosteroid therapy, antibiotics, thrombocytosis (congenital adrenal correction of fluid and electrolyte hyperplasia and infections) thrice disorders. To eliminate bacterial inoculation of all biological heamoblastosis with primary fluids should be included to plan of thrombocytosis myelogram was examination to provide target conducted, pathology was not antibiotic therapy. Conversely, in the revealed. After empirical antibiotic case of persist thrombocytosis in therapy by meronem general absence of an obvious cause, total improvement and normalization of hematological examination must be all parameters of blood test were conducted.

Koval V.A., Kolesnik V.O., Omelchenko A.V. PEDIATRIC SPINAL MUSCULAR ATROPHY AS A SYNDROME OF FLACCID CHILD Supervisor – Omelchenko O.V. Kharkiv National Medical University

Proximal spinal muscular Case report. The child N. of 1 atrophy (SMA) of childhood is a year 4 months was admitted to the severe, often fatal monogenic department of anesthesiology and disease, inherited in an autosomal intensive therapy with complaints of recessive manner. Pathogenetic basis the absence of physical activity in the of the disease is an affection of motor upper and lower limbs, cramps, alpha neurons of the anterior horns refusal to eat, weight loss, dyspnoe. of the spinal cord. This disease is The boy was born from the second connected with mutation of gene normal pregnancy in gestational age SMN1 (survival motor neuron-1) in of 40 weeks. Delivery was 5q13. physiological. The older child in 225

ISIC-2016 Abstract book family had trisomy 21. At the first tendon reflexes were absent. days of life the mother noted Breathing was superficial, decrease in general motor activity, arrhythmic, dyspnoe. While weak cry, skin jaundice. At the age of percussion in the lower parts of right two weeks, there was a decrease in lung pulmonary sound was dull; muscle tone of the upper and lower while auscultation breathing was extremities, absence of sight fixation. weakened. Cardiac tones were After the 2nd week of life there was a rhythmic, muffled with tachycardia. general muscular hypotonia, On the chest X-ray there was a right movements of legs disappear, focal confluent pneumonia. Child was distinct dyspnoe. Because of this, supported by ALV, due to a distinct child was examined by a neurologist dicrease of oxygen saturation. The and a geneticist. Basing on the child spent 365 days in the results of molecular genetic studies department, a tracheostomy was the deletion of the 7th and 8th exons made because efforts to recover telomeric SMN1 gene in the spontaneous breathing were not homozygous state (spinal muscular effective, the feeding was carried out atrophy) has been detected. Results through a tube. During his stay in the of electromyography detected signs hospital pneumonia had undulating of a lesion of motor neurons of the character; child received spinal cord. At the age of 4 months a symptomatic, pathogenetic therapy progressive deterioration with and drugs that improve trophism of increasing bulbar syndrome, distinct the nervous tissue. Despite reduced muscle tone and limited conducted complex therapeutic active movements was observed. measures, the child's condition Tendon reflexes from upper and progressively worsened and he died lower extremities were absent. While of a cerebral, cardio-respiratory, admission condition was severe with renal failure. respiratory insufficiency of II-III Suchwise, after the detection of degree; infant was flaccid, adynamic, the symptoms of weakness and malnutrition of III degree, funnel diffuse hypotonia in children, chest deformity was observed. While physicians should suspect high examination, there were no active probability of the diagnosis of SMA. movements, areflexia presented,

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ISIC-2016 Abstract book Aboghedeh A.M., Abughadeh A.R., Asibey A.G., Shuaibat M.A., Lupaltsova O.S. THE CELL IMMUNITY COMPONENT IN CHILDREN WITH REACTIVE LYMPHADENOPATHY Department of fundamentals of pediatrics №2 Kharkiv national medical university, Kharkiv, Ukraine

Actuality. The reactive had reduced level of the absolute lymphadenopathy is the reversible number of leukocytes in 21 (75±8,3%) enlargement of lymphoid tissue of cases. The absolute number of secondary to antigen stimulus. The lymphocyte in 15 (53,6±9,6%) children underlying mechanisms of the lymph and lymphocyte relative amounts in the node response to antigen stimulus in blood from subjects in 17 (60,7±9,3%) children has not yet been completely of patients were decreased compared elucidated. Aim: to evaluated the to normal lymphocyte relative amounts cellular immunity in blood in children according to age. The decreased levels the reactive lymphadenopathy. of absolute number of CD 3+, CD 22+, Material and methods: the 28 CD 4+, CD 25+ lymphocytes were patients were recruited from Regional detected in 10 (35,7±9,2%), 4 Children Clinical Hospital №1, Kharkiv. (17,9±7,4%), 9 (32,1±8,9%), 13 Children with the reactive (46,4±9,6%) of children, respectively. lymphadenopathy (n=28) aged on We studied that blood from subjects of average (5,9±2,4) years who had been patients with the reactive admitted to the immunology lymphadenopathy had a higher levels department. The reactive of CD 8+ lymphocytes in 5 lymphadenopathy was defined (17,9±7,37%) and CD 16+ - according to the protocol of diagnosis lymphocytes in 12 (42,9±9,5%) of and treatment diseases of the immune cases. system in children. The immunology Conclusion: the present data blood testing was collected after show that the decrease in cellular clinical evaluation. Statistical analysis immunity indicating a significant role was performed using „Statistica-6”. in the pathogenesis of the inadequate Results: we found that children inflammatory response with the with the reactive lymphadenopathy activation of the cytotoxic component.

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ISIC-2016 Abstract book

Lysak Maryna, Kysil Irina SPECIFICS OF AUTONOMIC REGULATION OF TEENAGER'S ORGANISM: MEDICAL AND SOCIAL PROBLEMS Research advisior: Atamanova O.V. Assoc. prof. Department of Propedeutics of Pediatrics No.1 Kharkiv National Medical University

Actuality. Vegetative-vascular №5. All the teenagers were held disorders are one of the urgent blood pressure (BP) and heart rate problems of modern medicine. This (HR), to test and thereafter. The is due to several factors and study was conducted according to especially the huge prevalence of international standards. The children autonomic disorders in adolescents. were divided into 2 groups: І - According to numerous children with vegetative-vascular epidemiological studies in dysfunction and II - children without populations of autonomic disorders, a diagnosis of VVD. occurring in 25-80% of cases. To date, the issue remains controversial Results: in analyzing the terminology, classification, results of the study found that pathogenesis, clinical diagnosis children and of average blood eligibility vegetative - vascular pressure at rest places: systolic - dystonia (VVD) as the underlying 128,3 ± 4,2, diastolic - 74,4 ± 3,9 mm disease, given the lack of nozoformy Hg and HR 84,22 ± 1,19 to pass; in ICD-10. Children in the second group systolic blood pressure - 122 ± 6,0, diastolic - The aim explore the adaptive- 70,6 ± 4,3 mm Hg and HR 78,01 ± compensatory mechanisms of the 0,98 in accordance pass. After the organism teens depending on the test Shalkova 16.5% of children and availability of diagnosis of vegetative 13.3% of children and the second - vascular dystonia (according to group experienced an increase in medical records) and define the systolic blood pressure (SBP) within medical and social problems of the 10-15%, diastolic blood pressure topic. (DBP) in the range of 5-10% and heart rate within 15 -20%. The Materials and methods: in a increase more than 20% of the study of 50 teenagers participated original values SBP, DBP and heart Kharkiv Lyceum №89 aged 12-16 rate was observed in 7.2% of years (24 girls and 26 boys). Cards children and of children and 6% of were analyzed medical students the second group. Reduction of conducted functional tests Shalkova

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ISIC-2016 Abstract book relevant indicators were not Therefore, to maintain the health of observed nor any child. the population of child health and teaching staff shall be required not to Conclusions: thus, adaptive - limit physical activity of children and compensatory possibilities of adolescents on physical education in children does not depend on the schools for the diagnosis of availability of diagnosis VVD. vegetative - vascular dystonia.

Muzhanovskyi V., Malich A., Lysytska N. APERT SYNDROME OF NEWBORN Research advisor: Malich T., assistant professor Department of pediatric №1 and Neonatology , Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. Primary term, with body weight 2.7 kg and craniosynostosis refers to closure of length 50 cm, Apgar scored 6/7. one or more sutures due to Mother developed polyhydramnios abnormalities of skull development at 34 weeks gestation. Newborn has secondary craniosynostosis results developed stigmata, although from failure of brain growth and appearing to be in good health. expansion. Objectively the faces tend to be The aim is to study of asymmetric, the eyes are proptotic, newborn with Apert syndrome. orbits shallow, widely spaced, Materials and methods: antimongoloid slant of palpebral under observation there was a fissures, syndactyly of the 2nd, 3rd, newborn with Apert syndrome. The 4th fingers, which be joined to the careful study of anamnesis, clinical thumb and the 5th fingers. Similar investigation, monitoring of vital abnormalities occur in the feet. functions has been carried out. During 3 days the general condition Results: apert syndrome is within normal. Newborn was usually a sporadic condition, consulting with orthopedics and although autosomal dominant discharge at home with inheritance. Apert syndrome recommendation. Newborn made a characterized by diagnosis: Aper syndrome, 1 type. acrocephalosyndactyly. Conclusion: due to typical Under observation the was a phenotype diagnosis has been neonate, who was born in perinatal established. center, from the first gestation on

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ISIC-2016 Abstract book Nagieva K. F. COMBINATION OF HEREDITARY MOTOSENSOR NEUROPATHY WITH HYPERHOMOCYSTEINEMIA AND FOLATEDEFICIENCY Research Advisor: the Candidate of Medical Sciences Molodan L. V. Kharkiv Specialized Medical Genetic Center Kharkiv, Ukraine

Actuality. Hereditary neurological department, where he motosensor neuropathies - was examined. Received therapy. He genetically heterogeneous group of was discharged with the diagnosis of: clinically polymorphic diseases with Hereditary neuropathy. Scoliotic progredient character of the course, posture. Per cavus bilateralis. leading to disability. Determination Secondary cardiomyopathy of mixed of certain metabolic disorders in this genesis. In the future - repeated group of patients allows to adjuste hospital treatment with the same conducting tactic of patients, thereby diagnosis. In November 2015 – slow down the progression of the hospital treatment in specialized process. sanatoriums. Diagnosis: Hereditary Materials and methods: polyneuropathy of the lower limbs. patient G., 17 years old boy, Scoliotic posture. Diagnosis when complained of fatigue during hospitalized: Hereditary physical activity, cramps in the calf polyneuropathy of the lower limbs. muscles, emaciation of the lower Scoliotic posture. In phenotype: pink limbs, feet deformity, difficulty in color of the palms, thin hair, long walking, unsteadiness. Parents find face, short nose, long neck, scoliosis, child sick from the age of 10 years, Friedreich’s foots, amyotrophy. when they noticed that the hands of Pedigree: the uncle of the boy is sick child are toned during sleeping. In on hereditary neuropathy; the aged 13-14, noticed that the child mother of the boy and his uncle are changed gait, did not get completely have the Friedreich’s foot. on foot, later lossing of feet and Results: karyotype - 46, XY, hands weight was observed. The Ultrasonography of internal organs: child was hospitalized in the Inhomogeneous structure

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ISIC-2016 Abstract book Onwujekwe Udodi HAEMATOLOGICAL MANIFESTATIONS OF HELMINTHIASIS IN CHILDREN Research advisor: Afanasieva O.A., M.D., PhD Department of Pediatrics No. 2

Kharkiv National Medical (in 8 children), rarely - enterobiosis University, Kharkiv, Ukraine (3), ascariasis (2), giardiasis (3), and Actuality. Latent course of two children had a combination of helminthic infections with the ascariasis and toxocariasis. The development of clinical symptoms of complaints were observed mainly in other diseases (allergy, diseases of children with toxocariasis. On the blood system) and the examination of these children the peculiarities of helminthic life cycle following diagnoses were made: iron provoke difficulties in diagnostics deficiency anemia (43.7%), and lead to long-term negative leukemoid reaction of the influence on the child's organism. eosinophilic type (18.7%), reactive The aim identification of lymphadenopathy (25.0%), hematological symptoms of hepatosplenomegaly (56 5%), long- helminthiasis in children. term fever (6.25%), acute Matherials and obstructive bronchitis (6.25%). The methods: we analyzed the case most common laboratory histories of 16 children age 1.5 to parameters were anemia – moderate 17years in the hematological to severe, leukocytosis up to department of Kharkov City 25*10^9 / l, eosinophilia (up to Children's Clinical Hospital No. 16, in 57%), high blood levels of γ- whom helminthic infestations have globulins (up to 44%) and Ig E (up to been found. 880 ME/mL), accelerated ESR (up to Results: main complaints of 45 mm/h). patients were the following: pale Conclusions: taking into skin, weakness, loss of appetite, taste account the high incidence of perversion (desire to eat chalk, soil, helminthic infections among children raw meat, butter), sleep disturbance, and the lack of specific symptoms, in fatigue, irritability, rise in body the presence of asthenic and anemic temperature, nausea, abdominal syndromes, hepatosplenomegaly, pain, disorders of stool (diarrhea or and lymphadenopathy in patients, constipation), disturbing them for a the plan of differential diagnosis long time (from several weeks to should include an examination for months). Among the identified helminthic infections. Helminthes, toxocariasis prevailed

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ISIC-2016 Abstract book Pliushko D., Lievashova A., Yanovskaya A. THE CLINICAL CASE OF THE COMBINATION OF PROGRESSIVE BECKER MUSCULAR DYSTROPHY, MITOCHONDRIAL DYSFUNCTION AND SECONDARY REACTIVE HEPATITIS Research advisor - Corresponding member of NAMS, M.D., Professor Grechanina H. Department of Medical Genetics, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Becker muscular pyramidal insufficiency. Additional dystrophy is an inherited disorder studies: biochemical analysis of that involves slowly worsening blood - lactic acidosis 4,13 mkmol/l, muscle weakness of the legs and persistent significant increase of CPK pelvis. It occurs in about 3 to 6 out of 7646,9, persistent elevation of every 100,000 births. Mitochondrial transaminases; GCMS of organic dysfunction — is typical pathological acids in the morning urine – there process that can be caused by are metabolites of mitochondrial different pathogens. It is important dysfunction and metabolic to study these disorders due to the disturbances of fatty acids with very presence of sufficiently effective long chain; EMG - signs of pyramidal therapeutic correction possibilities. insufficiency; molecular genetic study - deletion of 45, 47 exons of the The aim to study the features dystrophin gene. It was diagnosed: of the the combination of progressive Progressive Becker muscular Becker muscular dystrophy, dystrophy, mitochondrial mitochondrial dysfunction and dysfunction, secondary reactive secondary reactive hepatitis. hepatitis.

Materials and methods: we Conclusions: in this clinical studied the case history, published case we want to show the possibility data and the nature of the clinical of combining of different rare genetic manifestations, deployed in time. and acquired diseases, which have non-specific clinical manifestations. Results: nine-year-old child In such cases children need a was directed for consultation with comprehensive survey to identify the complaining of convulsive disorder, causes of the disease, medical and excessive mobility, impaired genetic testing to eliminate attention, fatigue.When he was three hereditary diseases. Only this years old the delayed speech diagnostic approach can help to development was diagnosed. choose the right tactics for each Neurological assessment: signs of patient.

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ISIC-2016 Abstract book E.Podgalaya, T.Teslenko, A.Senatorova FEATURES OF CONDITION OF CARDIOVASCULAR SYSTEM IN NEWBORNS WITH DIABETIC FETOPATHY Research advisor: doctor Gonchar Margaryta Department of Pediatrics No.1 and Neonatology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. If a pregnant edema - in 27.3%, petechiasis - in woman with diabetes has inadequate 18.2%, hypertrichosis - in 9.1%, glycemic control the fetus has systolic murmur at the apex of the already in the first trimester of heart - in 54.5%, hypoglycemia – in pregnancy signs of diastolic function 33.3%, respiratory distress disorders of the left ventricle (LV) syndrome - in 18.2%. Diabetic and also there is a high incidence of fetopathy (DF) was diagnosed in adverse neonatal period in 90.1% of children. newborns. According to ECG disorders of The aim of the study: to assess repolarization processes were the condition of the cardiovascular detected in 33.3% of newborns. system in newborns from mothers According to the results of with diabetes, to establish the Holter ECG-monitoring in infants frequency of cardiac arrhythmias, to with DF such features were found: determine the criteria of verification episodes of sinus tachycardia up to of diabetic cardiomyopathy (DC). 200 BPM (77.8%), atrial Materials and methods: the extrasystoles (44.5%), blocked atrial study involved 48 infants: the 1st extrasystoles (22.3%), elongation of group - 33 children from mothers the QT interval (22.3%) and with diabetes, the 2nd group - 15 disorders of repolarization (66.7%). healthy newborns. Our study is According to Doppler: moderate based on physical examination, dilatation of the right heart obstetric history and instrumental chambers and the reverse current on methods such as ECG, Holter ECG- the tricuspid valve I-II were found in monitoring, Doppler 72.7% of children with DF, echocardiography. regurgitation on the valve of the Results: first type diabetes pulmonary artery - in 18.2%, small was found in 84.8% of mothers, anomalies of the heart development - gestational diabetes - in 15.2%. All in 33.3%, atrial septal aneurismal women had complications during deformation - in 30.3%, transient pregnancy. The structure of the pulmonary hypertension - in 18.2%. clinical manifestations consists of: In infants with DF identified: changes macrosomia - in 21.2% of newborns, of the end-diastolic dimension of LV

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ISIC-2016 Abstract book more than 2 sigma-deviations Conclusions: in 87.9% of according to Z-score scale (p<0.01), infants with DF structural and thickness increasing of the back wall functional changes in the of LV (T>4.0±0.5 mm, p<0.05) and cardiovascular system were found. interventricular septum (T>4.7±0.65 They are hypertrophy of the mm, p<0.01); increasing of the ventricles, cardiac arrhythmias and pressure gradient in the outflow diastolic dysfunction of LV as slow tracts of LV more than 10 mm Hg relaxation type. The criteria for the (p<0.01), contraction dyssynergia of diagnosis of DC are hypertrophy of the myocardium - in 18.2%, diastolic the interventricular septum and back dysfunction of LV as slow relaxation wall of LV and increasing of the type - in 75.8%. pressure gradient in the outflow tracts of LV.

Popova T. O. FEATURES OF CARDIOVASCULAR RISK IN CHILDREN WITH BRONCHIAL ASTHMA Research Advisor: phD Tsyura O. N. Department of pediatrics № 1 and neonatology Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Bronchial asthma metabolism and vessels’ (BA) takes leading place among vasoconstriction. This may be the chronic diseases of respiratory cause of cardio-vascular and system. Chronic hypoxemia is the pulmonary failures in case of severe most common consequence of BA, stage of disease. Changes of the CVS especially in severe stages of the under conditions of the disease, and becomes the major bronchopulmonary pathology factor of cardiac dysfunction and develop slowly and for a long time pulmonary hypertension. High have an obliterated character. pressure and its further raising is Cardiovascular deviations in BA are important mechanism, which can potentially inversive in childhood change the myocardium what demands their early detection electromechanical activity, central and elimination. and peripherial hemodynamics, The aim evaluation the risk heart diastolic function. Functional development of cardiovascular changes of CVS in patients with BA disorders in children with bronchial occur as a result of hypoxemia asthma. negative effect on myocardium 234

ISIC-2016 Abstract book Material and methods: the 85 right ventricle (ddpg) of the 2gr. children from 7-16 years who had were significant (r=-0,56, p≤0,012). bronchial asthma were observed. In the period of remission in all The 1th group (1gr.) - 37 children groups are saved direct correlations with mild persistent asthma, the 2 between parameters of RFO and PLA, group (2gr.) – 48 children with especially with RFO-ex (1gr.r=0,743, moderate and severe bronchial p≤0,002; 2gr. r=0,76, p≤0,001). In asthma. Examination were carried the 2gr.were indicated direct out in the period of exacerbation and relationship between RFO and ddpg remission. To evaluate pulmonary (r=0,63, p≤0,001). And moderate hemodynamics used by Doppler significant inverse relationship echocardiography. External between PLA and MEF-25 (r=-0.52, respiration function was studied use p≤0.001); and FEV1 with ddpg a method of pneumotachography (r=0.48, p≤0,001). with measurement of the indexes: Conclusions: functional FEV1, MEF-50, MEF-25, pulmonary condition of the cardiovascular volumes, respiratory resistance system depends on type and severity (RFO). Statistical analyses were of bronchial asthma: in the period of performed with a statistic package remission saved unidirectional “Exel” and “STATISTICA 7.0”. relation of children of the second Results: reliable direct relation group, which is associated with between indexes of PLA and RFO has severe course of bronchial asthma been established in the period of and the possible remodeling of the exacerbation (r=+0,67, p≤0,012 - in pulmonary vessels and airways, 1gr. and r=+0,75, p≤0,001 -2gr.). what can increases the risk of Inverse relation between MEF-50 cardiovascular disorders and the diastolic diameter of the development.

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ISIC-2016 Abstract book Potikhenska K. TRAUMATIC LEUKEMIA MASKS IN CHILDREN Mentor: Ass.Professor Piddubna I.N. Pediatric department #2 Kharkiv national medical university

Actuality. Problem of leucosis petechial rash on the mucous in children is especially important membranes and ecchymosis without for modern health care. It is caused cause. Initially, children were placed by its rising trend, high morbidity in connection with the diagnosis of and mortality. trauma pathology, however, acute Aim. To increase practical lymphoblastic leukemia was health care physicians alertness diagnosed with the additional during differential diagnosis of bone examination. At present, children are lesions in children. at the protocol treatment, supportive Materials and therapy or removed from the methods.Submitted 4 extracts from register in connection with the the history of disease in children recovery. who were observed for a long time, Conclusions. The differential and traumatologists treated in the diagnosis is a complex thought trauma hospitals, whose primary process, which leads to simplification disease was acute leukemia. of diagnostic errors. Treatment of Results. Children arrived to the disease and its outcomes largely hematological department with depend on the knowledge, complaints for general fatigue, fever, experience and - most importantly - loss of appetite, the appearance of a doctor's care.

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ISIC-2016 Abstract book Isa Mashkur Abdulhamid, Patel Priyanka Harishchandra, Uliana Ivanivna Marusyk THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL-AGE CHILDREN WITH SEVERE ASTHMA Bukovinian State Medical University ({Department of pediatrics and children’s infectious diseases}, Chernivtsi, Ukraine)

Introduction: A major study atopy, standard household, challenge among modern pediatric epidermal, pollen and food allergen allergic diseases is bronchial asthma. was used. Assigning asthma control therapy to Clinical and epidemiological children should be considered based risks, as well as the diagnostic value on the phenotype. Hence, of individual indicators of atopic performance of atopic reactivity in reactivity for severe asthma children that reflect the specific phenotype verification were defined. pathogenic mechanisms of asthma Results: About one in three will personalize treatment and thus patients (36.4%) with the phenotype improve management of asthma. of severe asthma recorded Aim: To increase the significantly increased content of IL- effectiveness of treatment of severe 4 (more than 10.0 pg/ml), while only asthma phenotype in school-age 15.5% in the second group children, taking into account the (Рφ<0.05). There was increased risk diagnostic value of atopic reactivity of relatively raised content of IL-4 indicators. and IL-5 in serum of patients with Materials and method: 60 severe asthma. Almost every second school-age children suffering from child suffering from severe asthma asthma were comprehensively noted increased concentration of IgE examined in the pulmonology (>545.3 IU/ml). There were department of Chernivtsi Regional significantly more frequent cases of Children's Clinical Hospital. The hypersensitivity to household study involved 30 pupils with severe allergens in the group of patients asthma and 30 children with with severe asthma. Thus, a moderate course. The content of hyperaemia of more than 15.0mm serum total immunoglobulin E(IgE), was recorded in 81.5% of children of IL-4 and IL-5 were determined by the first group and only in 51.9% enzyme-linked immunosorbent (Pφ<0.05) of the second. assay (ELISA). Determination of Conclusion: The phenotype of immediate type skin sensitivity to severe asthma raises the risk of nonbacterial standard allergens was increased content of IL-4 and IL -5 in performed by intradermal tests. To serum by 3.1 times. However, this

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ISIC-2016 Abstract book paraclinical test is rather suitable for chances of severe asthma being verification of this phenotype (Sp – present. Increased sensitivity to 84.6% (95% CI 75.9-91.1)) than for domestic allergens (hyperemia more its detection (Se – 36.4% (95% CI than 15.0mm) allows severe asthma 26.9-46.6)). Concentration of total specificity verification (81.5%) and IgE in serum of more than 545.3 personalization of treatment policy IU/ml in children doubles the in these patients.

Rud Viktoria EARLY SYMPTOMS OF ACUTE LEUKEMIA IN CHILDREN Research advisor: Afanasieva Oksana, PhD., Piddubna I.N., PhD. Department of pediatrics №2 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Acute leukemia is months, and in 11.5% of patient – in relating to one of the most serious 6-12 months. The most common and important problems of symptoms on admission were children`s hematology. Nowadays weakness (76.9%), decreased timely diagnosis of this disease is one appetite (61.5%), pale skin (61.5%), of the main aim taking into account pain in bones and joints (30.8%), modern capability of chemotherapy hemorrhagic rash (53.8%), weight (achieving of remission in 80% of loss (15.4%), enlargement of lymph children with acute lymphoblastic nodes, liver and spleen (84.6%), leukemia and in 45% of acute increase of body temperature up to myeloid leukemia). febrile figures (57.7%). These The aim to investigate modern children with diagnosis of anemia, peculiarities of acute leukemia lymphadenopathy, hemorrhagic manifestation in children. vasculitis promptly got under the Materials and methods: we supervision of a hematologist. Onset analyzed the clinical data of 26 of the disease under the mask of children aged from 6 months to 18 infectious pathology significantly years, who were treated at the complicated early diagnostics. hematology department of Kharkiv Sometimes the disease started with City Clinical Hospital №16 with acute abdominal pain. These children were lymphoblastic leukemia (76.9%) and directed to the surgical hospital with acute myeloid leukemia (23.1%). a diagnosis of ""acute abdomen"" Results: in the majority of that delayed start of treatment and children (57.7%) diagnosis was influenced the prognosis. made in 2 weeks to 2 months from Analysis of laboratory data appearance of the first symptoms, in showed that on admission 92.3% of third of patients (30.7%) – in 4-6 children had decreased level of 238

ISIC-2016 Abstract book hemoglobin; in 34.6% of them severe 84.6% of children, accelerated ESR - anemia was revealed, in 30.8% - in 76.9%. moderate, and in 26.9% - mild Conclusions: presence of anemia. Leukopenia was found in symptoms of intoxication in 34.6% of children, leukocytosis - in combination with one or more 42.3%, in 15.4% of children syndromes - anemic, hemorrhagic, hyperleukocytosis more than hyperplastic, immunodeficiency, 100x109/l was observed. 88.5% of requires exclusion of acute leukemia. patients had thrombocytopenia, in Taking into account the variety of 38.5% quantity of platelets was less ""masks"" of this disease, lack of than 30x109/l, provoking adequate therapeutic effect of pronounced manifestations of standard therapy clinical blood test hemorrhagic syndrome. Blast cells in in dynamics and hematologist`s peripheral blood were detected in consulting is necessary.

Semenyuk M, Kyslov O.V, Pakhomova A.V. REFRACTIVE TYPES IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA Research advisor: Pakhomova A.V. Department of Ophthalmology Kharkiv National Medical Iniversity Kharkiv, Ukraine Actuality. Pathology of the The aim was to analyzed type connective tissue may appear of refractive in patients with CTD. dysplastic changes, not only in one Materials and methods: 52 organ, but also multiple organs. eyes in 26 patients with EDS were Connective tissue dysplasia (CTD) is included in the study. Male:Female characterized by the systematic ratio was 7:19. Mean age was destruction and the local nature of 11,5±2,3 years (from 7 to 16). All the manifestation is caused by their patients were underwent common own structural features, in ophthalmologic examination. particular, a violation of the Results: analysis of refraction architectonics of collagen fibrils, revealed: in the 69,23% of cases in resulting in considerable patients with СТD (36 eyes), were extensibility connective tissue. diagnosed myopia, the average value Additionally constitutional features, of which was 2,73±1,41D. large of phenotypic diagnostic Myopic astigmatism diagnosed features, there are small anomalies, in 15,38% (8 eyes), which amounted which can act as a stigma to an average value -0,51 ± 0,57 D. dysembryogenesis in this pathology. From the group of patients studied in any case not above 239

ISIC-2016 Abstract book mentioned myopia 6,0 D, according of refraction in connective tissue to the literature although high dysplasia was myopia. The findings myopia in patients with DST is a suggest that frequently encountered common disease. ocular manifestations during CTD The mixed astigmatism was include low and moderate myopia, observed in 11,53% (6 eyes). In myopic astigmatism. 3,85% was observed in both eyes Given the myopia caused by oblique hypermetropic astigmatism overstretching of collagen structures of 2-2.5 D, which is not typical for of the eyeball, you need an early patients with CTD. detection and regular monitoring of Conclusion: our research patients with this pathology by an showed that the most common type ophthalmologist.

Shakhzadian Lauritta SUBCORTICAL - CEREBELLAR DEGENERATION Research advisor: Uryvaeva Maria, assistant professor Department of Pediatrics and Neonatology N1, Kharkiv national medical university, Kharkiv, Ukraine clinic. The peculiarity of seizures in Actuality. Subcortical and this child was gemioklonichesky cerebellar degeneration is a type of syndrome, which is characterized by cerebral malformation characterized a constant limb clonus, despite high by underdevelopment or absence of doses of combined anticonvulsant functional parts of the cerebellum, therapy. Life history is burdened, which in the clinical picture interruption threat gestational age presented in the form of cerebellar 32-33 weeks, delivery on time with disorders of varying severity. Me the weakness. Up to 7 months old presented a clinical case of baby behind in psychomotor subcortical and cerebellar development, the first neurological degeneration in the background of symptoms appeared after SARS, congenital disorders in the oxidation requiring exceptions of fatty acids, complicated by Reye- neuroinfections, MRI of the brain in like syndrome, which was confirmed which the diagnosed subcortical and morphologically. cerebellar degeniratsiya. Following Materials and methods: the initial treatment, the disease was of a child A., 1 year 3 months., admitted progressive nature, which made it to the clinic for the first time at the possible to assume the inherent age of 8 months with manifestations metabolic disturbance that is of seizures, which were clarified confirmed in MHz Kharkov and genesis of the child's stay in the typed as a violation of the exchange 240

ISIC-2016 Abstract book of fatty acids in the oxidation. A child resuscitation, biological death was over 5 months was constantly under pronounced. At the postmortem the supervision of doctors, but the examination of biopsy specimens: layering of viral disease has resulted liver - liver diskompleksatsiya beam in metabolic catastrophe in the form structure, hepatocytes are able to of oppression of the central nervous large-drop adipose degeneration system, myoclonic seizures, which with a break tsitolemmy and were continuous in nature, not cytolysis. Kidneys - in terms of amenable to medical correction and epithelial tubules fat distofiya - the emergence of progressive liver intracellularly within the cytoplasm dysfunction in the form of cytolysis of fat vacuoles. The brain - (exceeding 10 standards) phenomena expressed perivascular, hyperbilirubinemia due to direct peritselyullyarnogo and perinuclear fraction and hypoproteinemia (viral edema. hepatitis are excluded), which was Conclusion: the clinical seen as the development of feature of this case lies in the complications such as Reye's combination of subcortical and syndrome. Against the background of cerebellar degeneration on the the child's condition deteriorated background of metabolic disorders therapy, complicated multiple organ of fatty acids with the further dysfunction syndrome (cerebral, development of Reye-like syndrome. respiratory), and despite

Strelkova M., Silicheva A. THE RISK FACTORS OF THE DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN CHILDREN WITH GASTROENTEROLOGICAL DISEASES Research advisor: Omelchenko O., assistant professor Department of Pediatrics №1 and Neonatology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Recently rapid The aim of the article is to development of preventive medicine examine stratification of the risk based on preventive and corrective factors for cardiovascular diseases in measures. Risk factors for children with diseases of the cardiovascular diseases are divided digestive system. into modified (smoking, obesity, Materials and methods: the dietary factors, low physical activity) survey respondents were 66 children and the non-modified (individual aged from 2 to 17 years, girls - 32 medical and family histories). (48.5%) and boys - 34 (51.5%) with 241

ISIC-2016 Abstract book digestive diseases. The analyzed parents, pale skin - 19.7% of anthropometric data; generally children, 24.2% of parents ,vascular recognized clinical laboratory and pattern on the skin - 13.6% of instrumental diagnostics, the children, 10,6% of parents. "Genetic questionnaire" were used to Cardiovascular diseases had 28.0% verify the children’s diagnoses. of parents. Overweighed or obese Results: the anthropometric were 22.7% of parents. Furthermore, data analysis of the exanimated 36.4% of the surveyed children led a group of children showed that 42.4% sedentary lifestyle. Posture of patients had normal level of BMI, abnormalities had 45.5% of children 30,2% of patients had the increased and 6.9% of parents, propensity to level of BMI and 24,0% of patients fracture of bones - 15.2% of the had low level of BMI. The analysis surveyed children and 3,1% of showed that the normal blood parents. pressure had 69.7% children Conclusion: the important prehypertension had 10.6% children factor of the development of and the stage 1 hypertension had 9 cardiovascular disorders in children (13.6%) children. Muffled heart with chronic diseases of the digestive sounds was observed in 22.7% system can be genetic defects of patients, functional systolic murmur folate cycle enzymes and the risk in 37.8%, ECG changes in 68, 2%, factors: early cardiovascular diseases monotop heart rhythm disturbances in family anamnesis, smoking, in 50%. According to the data overweight or obese. Stratification of ECHOCG r mild dilatation of the left the risk determines the probability ventricle was registered in 30.3% of development of cardiovascular patients. The results obtained by the diseases; affects treatment strategy, “Genetic questionnaire” was allows to assess the individual revealed: blonde hair in 54.5% of prognosis and to identify groups for children, 68,5% of parents, blue eyes social and medical support. - 28.8% of children, 30.3% of

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ISIC-2016 Abstract book Timoshenko Maxim, Kubeev Erbol SYSTEM FOR MONITORING THE STATE OF HEALTH OF CHILDREN AS A TOOL FOR IMPROVEMENT OUTPATIENT SERVICE (FOR EXAMPLE KENTAU) Research advisor: doctor of Medicine, Professor Buleshov Myrzatai Department of Public Health-1 South Kazakhstan State Pharmaceutical Academy Republic of Kazakhstan, Shymkent

Actuality: The analysis of the in the South Kazakhstan region state of health of the child population marked increase in the incidence the Republic of Kazakhstan shows level for uptake among children that it is much worse than in most under 14 years of age - 1.5 times to industrialized countries. If in the about 1801.1% to 2701.65% of near future will not be significantly among adolescents up to 18 years - changed by the factors affecting by 1.1 times to 970.2% of up to health, we should expect its further 1067.22% of. It was revealed that the deterioration. average incidence according to World Health Organization, checkups for children from 0 to 7 development and reform of primary years was 655.3% on a downward health care is defined as a priority, trend during the study period from the implementation of which ensures 520.9% of (2008). To about 342.3% progress on all countries' health. (2010. ) after the proposed health Strengthening the health of children and organizational measures. In the largely depends on the level of structure of morbidity from data organization and quality of care, checkups ranks first disease of the systematic observation (monitoring) musculoskeletal system of 151.2%, the health of different groups of the second place - respiratory children of targeted preventive and disease of 127.5%, the third place - promotive efforts. diseases of the circulatory system to Aim: To substantiate and -113.0%. develop measures to improve the Conclusion: The system of organization of therapeutic and monitoring the state of the child preventive care for children in South population and adolescent health Kazakhstan region in outpatient provides an opportunity to optimize clinics on the basis of the results of pediatric care at the regional level to the study of dynamic child morbidity. identify the needs of children and Materials and Methods: adolescents in the pediatrician, as Questionnaires, statistical analysis, well as specialized forms of care to comparative analysis. the outpatient phase of care. Results: It was found that during the period from 2006 to 2016

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ISIC-2016 Abstract book Tiwari Pawan Kumar, Oyebamire Mussa Abimbola INNOVATIVE BIO-TECHNOLOGICAL DEVELOPMENTS OF UKRAINIAN SCIENTISTS IN THE AREA OF PROBIOTICS Research advisor: Panko N., Candidate of Medical Sciences Department of Pediatric V.N.Karazin National University, Kharkiv, Ukraine

Actuality. (AIT) is a chronic variants (MTHFR-677 and MTHFR inflammatory disorder of the thyroid 129) by (PCR). For statistical gland caused by abnormal blood processing of materials stagraphics antibodies and WBC that damage 3.0 and Student-Fischer test were healthy thyroid cells. As used. accompanying disease AIT with Results: in children with AIT rheumatic desease was studied in infection as a trigger factor of adult. Clinical manifestation of (JIA) manifestation of JIA more frequency in children with AIT is not (p<0.001) was found. In group of investigated deeply. patients with AIT more common The aim it was to analyze the symptom of JIA onset was arthritis of clinical presentation in patients with knee joints (p<0.001) in comparison JIA which is accompanied by AIT and with children of 2 group, where JIA possible relations with began from fever in 26.6 % patients, polymorphism of genes of folate from rush - 14.3 %. Joints syndrome cycle enzymes. in persons from I group Matherials and characterized by more frequent methods: 9 patients with JIA of age involving of ankle joints (p<0.001), group 2-18 years were divided in to presence of regional amyotrophy 2 groups according to presenting of (p<0.001), proliferative type of AIT. 25 % of patients, who developed arthritis without acute joint pain and AIT, were placed in main and swelling and with deformation and comparison group. The diagnosis of decreased range of motion of AIT was based on rised level of affected joints (p<0.001), fast thyroperoxidase antibodies, stT4, development of limited joints stT3 and USG of thyroid gland. The function I-III degree (p<0.001). megerment of genotypes of genes of Children with JIA in accompanying folate cycle,eg: 5- with AIT more frequently had methyltetrahydrofolate- neutral alleles (AA) of MTHFR1298 homocysteine (MTR), 5- gene (p<0.001) and heterozygous methyltetrahydrofolate- genotype of risk allele (AC) of homocysteine (MTRR), 5,10 MTHFR677 gene (p<0.001) in methylenetetrahydrofolate comparison with persons of II group. reductase C677T and A1298C Differences of genotypes of MTR and

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ISIC-2016 Abstract book MTRR genes in comparison groups by manifestation from knee joints, fell just short of statistical frequent involving of ankle joints, significance. proliferative type of arthritis, fast Conclusions: clinical development of limited joints presentation in patients with JIA function, frequently presenting of which is accompanied by AIT is neutral alleles (AA) in MTHFR1298 different in comparison with patients gene and heterozygous genotype of with JIA without AIT, it characterized risk allele (AC) of MTHFR677 gene.

Tkachuk Ljubov', Deonega Anna, Uryvaev Andrey ANTIPHOSPHOLIPID SYNDROME. CASE STUDY. Research advisor: PhD., docent Uryvaeva Marina Kuzminichna Department of Pediatrics and Neonatology №1 Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Antiphospholipid know that the child was born from I syndrome (APS) is a variant of pregnancy, occurring against the system thrombotic vasculopathy of backdrop of I half edema syndrome autoimmune origin. The disease is at mother. On the 3rd day of life the more common among young people child has a tonic-clonic seizures, in (20 - 40 years), but can also affect connection with which it was treated young children and infants. Late at the Department of Anesthesiology diagnosis of APS leads to and Intensive Care, where diagnosed dysfunctions of the central nervous intracranial hemorrhage, which was system, cardiovascular system, seen as a birth injury. At the age of 1 kidneys, liver, endocrine glands, year, the child had an episodes of gastrointestinal tract. tonic-clonic seizures occurred The aim describe such a rare against the background of raising disease of childhood with the temperature to 39°C. At the age of 1 definition of criteria for the diagnosis year 2 months old, attacks were with at the earliest possible time. fading and red face. Materials and methods: child Results: an objective D., 5 years 2 months old, was treated examination in the hospital: general at the neurology department of the state of moderate severity. Severity RCCH, Kharkov. In admission to of the condition is caused by hospital mother complained of neurological symptoms. The liver is attacks of tonic-clonic seizures in the palpated to +2 cm, dense right extremities, vomiting, cramps consistency. Spleen +1cm. in the background. From history we Neurological status: consciousness is 245

ISIC-2016 Abstract book kept, drowsy. The head is round. activity. MRI study of the brain: signs Marked flattening of facial muscles of asymmetric internal on the right. Reduced range of hydrocephalus. Based on these facts motion in the right extremities. were find the consequences of Reduced muscle strength in the right intracranial hemorrhage. During extremities. Proprioceptive reflexes treatment in hospital the child's increased, D>S. In the clinical condition improved slightly. analysis of a blood relative moderate Conclusions: feature of this neutrophilia, lymphopenia. case is the late diagnosis of Urinalysis and stool without antiphospholipid syndrome. Because deviation from the norm. APS is a system thrombotic Biochemical analysis of blood: vasculopathy, in the presence of increase in alanine aminotransferase organic CNS symptoms in the first to 0,25mkat/l. Antiphospholipid place, it is necessary to suspect this antibody IgG - 18,2 U/ml for IgM - pathology, and complex diagnostic 6.3 U/ml. ECG: sinus rhythm, procedures include a detailed repolarization broken. EEG pattern medical history, identification of expressed disturbances. Symptoms antiphospholipid antibodies AT IgG of paroxysmal activity presented in the blood. diffuse sharp waves, polygenic

Yanovska K., Moskalenko V., Tereshchenko S. Microbiological status of the children with cystic fibrosis in Kharkiv region Department of Fundamental Pediatrics #2 Kharkiv National Medical University, Ukraine

Actuality. The basic The aim to define correlations respiratory tract microflora in cystic of microbiological status in CF fibrosis (CF) is Staphylococcus patients with the disease morbidity. aureus (S. aureus) in the initial The materials and methods: period, then Haemophilus influenza 30 CF children are followed-up in the (H. Influenza) and Pseudomonas Pulmonology Department of aeruginosa (P. aeruginosa). In recent Regional Children’s Clinical Hospital years, the role of Burkholderia No. 1. 23 CF children (12 boys and 11 cepacia (B. Cepacia), Nontuberculous girls) underwent complete physical mycobacteria, Stenotrofomonas examination in 2014 year. Clinical maltophilia (S. Maltophilia), and paraclinic (bacteriological Alcaligenes xylosoxidans examination of sputum) were (A. xylosoxidans), Аspergillus sp. and performed. others has increased. 246

ISIC-2016 Abstract book Results: the following CF- with S. aureus, S. maltrophilia (1), specific respiratory pathogens were Acinetobacter (1), A. xylosoxidans determined in sputum culture in (2), B. cepacia complex – in 23 children, who were treated in the 3 (37,5 ± 17,1) %. The earliest age of Pulmonology Regional Children’s the observed chronic colonization Clinical Hospital No. 1. 23 in 2014: was 6 months. P. aeruginosa, P. aeruginosa – in 13 (56,5 ± 10,3) % B. Cepacia were significantly more children, in (80,9 ± 8,1)% cases the frequent in group of patients with heavy colony growth was observed, severe CF than in group of children and in (19,1 ± 8,1) % – the moderate with moderate severity (р < 0,05). growth; S. aureus – in Determination of these infections in 10 (43,4 ± 10,3) % patients, B. CF patients’ sputum may be the cepacia in (13 ± 7) % patients, adverse prognostic factor for the S. maltrophilia – in 1 (4 %), disease severity. Multi-drug resistant Acinetobacter 1 (4 %), strains of P. Aeruginosa were A. xylosoxidans 2 (8 %), Candida observed in groups of patients with 16 (70 ± 9,5) %.The most frequent severe CF in 50% and significantly association was combination of more frequent, than in group of P. aeruginosa + S. aureus in children with moderate severity. (22 ± 8,6) % patients, and The conclusion: P. аeruginosa + B. cepacia in 1) Condition severity of CF (13 ± 7) % patients. Except patients is associated with chronic P. Aeruginosa, the following infection by P. aeruginosa and B. nonfermentative gram-negative cepacia. microorganisms were determined in 2) None of patients in Kharkiv those associations – S. maltophilia – region has determined any of in 4 % patients. pathognomonic respiratory In the group of severe patients causative microorganisms – the chronic P. Aeruginosa M. Tuberculosis and non-tuberculous colonization was observed in micobacteria, H. influenza, Ralstonia 8 (100 %) children, in picketi. 4 (50 ± 17,6) % of them – together

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ISIC-2016 Abstract book

PREVENTIVE MEDICINE

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ISIC-2016 Abstract book Adeyemi А.А. THE EFFECTS OF SOME ENVIRONMENTAL FACTORS ON THE REPRODUCTIVE SYSTEM Research advisor: Chehovskaya I.N., MD Department of Hygiene No 2 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. According to recent epididymal cysts, hypospadias, and reports, 2-3% of newborns have cryptorchidism. Even the women congenital malformations. These who were on DES medication were malformations are caused by not spared as they showed higher interaction of genetic and rates of breast cancer development. environmental factors. Exposure of DBCP (dibromo-3-chloropropane), a paternal or maternal organisms to pesticide used in banana & pineapple environmental hazards may damage plantations. This pesticide has been germ cells resulting in malformation linked with azoospermia and of various organs. oligospermia in 64 to 90% of men The aim of the research, based exposed for 3 years, failure of on literature review discusses the spermatogonial development in rats. effect of selected environmental DBCP-treated human sperm does not factors on the female and male penetrate the oocytes.Paternal reproductive system, fetal exposure to: Hg, ethylene oxide, development and growth. rubber chemicals, solvents have been Materials and methods: linked to spontaneous abortion, severalresearch publications, there have been links between journals, write ups and articles. painters and anencephaly, Results: In the 1930s, DES welders/mechanics and Wilms (diethystilbestrol), a synthetic tumor, Textile industry workers and hormone was developed with the still births/pre-term delivery. aim of preventing miscarriages. DES Conclusions: given the was administered to approximately persistent nature of DBCP 10 million women worldwide and contamination in areas of past use, caused devastating damages to and also other environmental females. For instance, mothers who factors, efforts should be made to took DES had daughters who later remediate these areas and to follow suffered from clear-cell vaginal exposed populations for adenocarcinoma, uterus development of certain human abnormalities and difficulties in cancers, including breast, ovarian, conceiving. Male offspring were not stomach, and respiratory, oral and spared, as they also suffered from nasal cancers, among others. It is

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ISIC-2016 Abstract book important to study more of these health, and thus prevent their environmental factors to determine catastrophic consequences. their effect on human reproductive

Alale Mumuni Anass, Sibamba Mutelo Faith INFLUENCE OF EMOTIONAL AND VOLUTIONAL SPHERE ON THE STUDENT’S EDUCATIONAL ACTIVITY Research advisor: KulikovaI.I. Department of Ukrainian language, principles of Psychology and Pedagogy Kharkiv National Medical University Kharkiv, Ukraine

Actuality. Contemporary who comes from another country for world is a difficult, ambiguous time studies, it is a peculiar stress, that to that combines with globalization, the overcome requires time. At first, the military and religious conflicts, process of the adaptation is fast, information technology and low level which is caused by new friends, of economy. Some times in this world classes and individual characteristics it is difficult to find the correct (temperament, character, ability). guidelines, priorities and especially But at the same time, the student for a young person, whose psychis often feels loneliness and despair, not yet completely formed and can because sometimes friendship is not asily give into negative influences formed with the group members. from outside. Also the fear may be caused by the Aim of this work. To reveal the (presentiment accomplishment in influence of emotional and volutional the full) volume of the academic load. sphere on foreign students while All these factors lay heavy weigh to study in gat the university. his emotional state. As a result, he Results: contemporary does not feel the inner harmony and research in psychology and the pleasure of learning, then loses pedagogy demonstrate that it is interest in any cognitive activity. important for every student (both As a result, there are problems with Ukrainian and foreign students) that attention, to replace the joy, not only his physical condition, but openness, sincerity come pessimistic also the ability to consciously thoughts that lead to stress. The respond to the processes of the stress that build sup, preventing the environment reflects in the brain and full and multifaceted life of a young are relieved like satisfaction ordis man narrows the range of his pleasure in this emotional state and interests to a minimum and may volutional sphere. For a foreigner even lead to frustration, 250

ISIC-2016 Abstract book disorganization as lack of awareness goals and go hard for it and and training activities. understand that the problem is part The student should not be exposed of our lives and try not to focus only to the seemotions, do not try to run on them butal so realize that there is away from this, and try to analyze another side of life. It is necessary their behavior and actions, during training not to forget about understand, identify the cause, the free time to visit gyms, museums, rectify the situation and avoid it in cultivate aesthetic feeling and the future. confidence and to educate the feels Conclusions. That to avoid of respect to other opinions, discover appearance of stressful situations, it the new skylines for dreams and is necessary to think positive, set achieve them.

Andrew Brian Amoah-Danful, Reznichenko O.G., Grygorian O.V. PSYCHOLOGICAL EFFECTS OF SOCIAL MEDIA Research advisor: Korobchanskiy V., Doctor of medicine, Professor Department of Hygiene and Ecology No.1 Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Introduction. We live in an age Materials And Methods. A of massive technological group of thirty students currently advancement and find ourselves on a residing in Kharkiv, Ukraine were daily basis surrounded by computers involved in the study. Participants of all sizes that have immense power. were asked a series of questions In our desire to be connected to within a three week period other people all over the world, concerning their use of social media. various “social networks” have been Furthermore software installed on brought into existence by virtue of their phones and tablets was used to the internet. The result of all this is measure the time spent on social unprecedented interaction with media applications and websites. electronic screens in our need to be Results. Out of the 30 “online”. participants, 29 admitted to Aim. To determine the extent of regularly being distracted whilst in the psychological toll that social class by notifications, 25 to spending networks such as Facebook, time on their phones when they Snapchat, Instagram as well as were in a room with other people, 24 messaging applications like to regularly being indoors for more WhatsApp have on the population, than 4 hours a day because they with a special look at the effect on were on their phones or tablets, 20 students. to sleeping at least an hour later than 251

ISIC-2016 Abstract book they normally would without access of notifications that make students to social media and 12 also said they vulnerable to distractions. Students’ found it quite difficult to sleep at sleep also seemed to be affected. night. Also 15 of the 30 believed that Studies by Burkhart and Phelps their usage of social media in one (2009) and Sasseville et al (2009) way or the other affected their point to the fact that blue light relationships with their close friends emitted by screens of mobile devices and relatives. Furthermore, students is a culprit in disrupting sleep. Also, that spent about 3 hours or more on as witnessed from the results, social platforms admitted to students who spent less time on succumbing more to depression than social platforms could make more in those whose usage was less. time for their studies. Finally, students who continually had However, the results obtained good grades were found to spend on for this study could not yet be fully the average not more than 45 ascertained as no control group was minutes a day on social platforms. involved in the study and subsequent There were exceptions, however, as work done will look into that. 2 excellent scoring students used Nonetheless it seems to be clear that social networks for about 4 and 5 social media does have a negative hours respectively, everyday. effect on mental health. Conclusion.Clearly, a major effect is seen is in the constant flow

Antonovich Svetlana SOME PROBLEMS OF SOCIAL AND PSYCHOLOGICAL ADAPTATION OF THE VISUALLY IMPAIRED DISABLED PEOPLE Research advisor: Samolysova Oksana Department of Ukrainian language, Principles of Psychology and Pedagogics Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The increasing which is accompanied by number of the visually impaired psychological difficulties of disabled people is one of the up-to- adaptation in the society. date problems of our society. The aim. This work is devoted Disturbing or losing of vision leads to to the peculiarities of social and the changing in mentality and psychological adaptation of the behavior. Such persons are visually impaired people to the characterized by their own rhythm conditions of modern society. opposite to the usual life stereotype Materials and methods: 252

ISIC-2016 Abstract book sociological interview, between persons with disabilities on questionnaires, training. the vision and others. Results. Defects of vision It is possible to overcome the disturb personnel interaction in the negative emotional states of persons society, as a result it is difficult to with disabilities in the case of establish and maintain social creating the conditions for a contacts, it is a so-called "falling out" successful compensatory adaptation. of society. There is a problem of The most important condition is the mutual relations developing between inclusion of the visually impaired members of different groups, persons in the activity, the forming of including disabled persons. The their positive motivation and peculiarities of such relations attitudes. As soon as the persons influence on the psychological state with disabilities are aware that they of the person, his attitude to can work, take care of themselves in educational work and social everyday life, they restore their activities, to others, to himself. social status if only partially are The blindness becomes a involved in activities. So it is psychological problem when people beginning of the process for going with disabilities are aware of their out a state of psychological conflict. own unlike healthy people. They Conclusion. Adaptive process cannot fully satisfy their material of the persons with disabilities is and spiritual needs (93% of necessarily accompanied by their respondents), content with a small active position in the groups. The range of interests (68% of purpose of communication, learning respondents), they are permitted to different ways of perceiving and engage in certain types of activity understanding the partners’ (77% of respondents). The person communicative act enables to with defects of vision shows negative significantly expand the area of character traits. For example, communication of each person with selfishness, stubbornness, the vision defect and thus realize negativism, indifference etc. Such their social and psychological traits as isolation, unsociability are adaptation. an indication of the limited contact

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ISIC-2016 Abstract book Bogachova O.S., Mensah Seth Omari, Skibo O.Yu. RISK FACTORS OF AGRICULTURE IN GHANA Hygiene and ecology № 1 Kharkiv National Medical University, Kharkiv, Ukraine

Introduction: Agriculture is a seminars also can help to educate risky business. Farmers and farmers and fishers on agricultural fishermen always have had to cope risk factors. with a wide variety of risks. Basically Results: some farmers and risk factors of agriculture are factors fishermen in some communities in that affect the environment Ghana are using the right way of negatively. Since 40% of health getting their products especially the problems in Ghana arise from use of natural fertilizers for soil and agricultural risk factors, my aim is to burning farming residues far away investigate about those risk factors. from the community which has Aim: my purpose is to prevented respiratory diseases. enumerate all the possible risk Fishers also use food and animals to factors of agriculture to the rather than chemicals or artificial environment and the things in it In light to attract fishes which also has order to understand a better way of prevented water borne diseases farming and fishing. since they have understood its Materials and methods: our hygienic norms. investigation states the possible Conclusions: thus, our effects of the risk factors therefore It investigation and preventable will be better to ensure the use of methods has been understood with information vans to educate farmers its hygienic norms thereby has and fishermen on the risk factors and minimized risk factors of agriculture ways they can farm and fish to which to some years to come prevent risk to the environment, agriculture would be done in a right moreover the organisation of way with risk factor free.

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ISIC-2016 Abstract book Dziuba. V. PATHOGENIC PROPERTIES OF EDIBLE MUSHROOMS Research advisor: Sarkis-Ivanova V.V., Dziuba V. Department of Hygiene and Ecology No. 1 Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. Mushrooms are the Eating these mushrooms without most balanced and nutritious sufficient heat treatment or even raw product of plant origin and contain can cause toxic effects on the human plenty of proteins, amino acids. It has body. The most toxic mushrooms are recently been more and more cases Amanita phalloides from Amanita of poisoning with edible mushrooms. family - contains toxic polypeptides, Together with edible mushrooms and amanitines, faloidines; Amanita grow their poisonous "doubles", muscaria - contains toxic substances representing a mortal danger to muscarinic, choline, putrescine, humans. Despite the well-known hallucinogen bufotenin; external signs of poisonous Gyromitraesculenta - contains heat- mushrooms annually occurs serious resistant hepatotoxic toxin mass poisoning ending in some cases gyromitrin. In recent years, edible with death. There are about 25 mushrooms researchers noted a high species of poisonous and harmful concentration of pesticides, heavy mushrooms in our country. metals, radioactive substances. When Poisoning can cause poisonous it enters the body, they cause mushroom or incorrectly cooked poisoning. Mushrooms can absorb edible mushrooms or "mutants" heavy metals from the environment. (mushrooms, which accumulate toxic Fungi contamination by heavy substances, degradation products of metals is more dangerous to humans mushroom proteins and waste when they enter into the structure of products of insects). the fungus and includes in the The aim To study how can biosynthetic process, forming edible mushrooms acquire unusual mushroom compounds, poisonous properties. toxic to humans. The main adversely Materials and methods. effects to the living organism include Bibliography semantic method. blocking enzymes, tissue respiration, Results of research.When the carcinogenic effects, mutation. fungus begins to grow old, the Artificial radionuclides makes the process of self-destruction, biomass greatest influence on mushrooms. decrease and reactions of Radioactive substances distribute in disintegration of tissues start. The the mushroom differently: the plates result is the formation of toxic contained 48%, the bonnet 33%, the protein source, ammonia, phenols. stipe 19%. Under the influence of

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ISIC-2016 Abstract book radiation occurs damage to DNA and properties in the process of aging of enzyme systems. The genetic the mushroom, the development of material of cells lose the ability to flies, worms that produce toxic waste reproduce and eventually dies or products, because of environmental creates a new cell progeny. These contamination with xenobiotics. In modified cells can give rise to addition, poisonous mushrooms generation of mushrooms with often mimic the appearance of unusual properties. edible. Conclusions. Edible mushrooms acquire pathogenic

Elkosh Mohamed Moneir STUDY OF ANTIBACTERIAL ACTIVITY OF COMBINATIONS OF TEA TREE ESSENTIAL OIL WITH ANTIBIOTICS AGAINST OPPORTUNISTIC MICROORGANISMS IN VITRO Department of microbiology, virology and immunology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Due to absence of a efficacy even with plasmid-conferred proper antibiotic policy or non- multidrug resistant bacteria. adherence to it firmly, common The aim of our research was strains of bacteria develop new to investigate synergistic outcome mechanisms of resistance to widely between the tea tree essential oil used antimicrobial agents which are (Melaleuca alternifolia) and used for many years. These strains antibiotics against facultative are still increasing in number by the anaerobic bacteria such as standard time. The resistance has been strains Staphylococcus aureus ATCC observed in both Gram-positive and 25923, Staphylococcus epidermidis Gram-negative bacteria isolated from ATCC 14990, Escherichia coli ATCC specimens of patients with 25922 and Klebsiella pneumoniae community-acquired and hospital- АТСС 5505. acquired (nosocomial) infections. Materials and methods: A new revolution in the field of Antibacterial activity of the tea tree combating antibiotic resistance is the essential oil and antibiotics was development of new studed by disc diffusion test pharmacological regimens by using according to recommendations of the combination therapy of conventional International Committee of Clinical antibiotics with essential oils as sort Laboratory Standards (NCCLS, of phytopharmaceuticals. This 2002). combination therapy exhibits 256

ISIC-2016 Abstract book Results: The tea tree essential enhanced the azithromycin, oil was dissolved in ethanol and cefuroxim and clindamycin activity introduced into melted and cooled against S. aureus. Doxycyclin and meat pepton agar at a concentration ofloxacin were more effective in of 70 mcg/ml or 0,007 wоlume %. combination with the tea tree Suspension of microorganisms essential oil against K. pneumoniae. (microbial load 2•109 CFU/ml) was Essential oil also potentiates the added on the surface of cooled agar effect of cefotaxime and ofloxacin then standard paper discs with against E.coli. antibiotics were placed. Inoculated Conclusions: Synergistic effect Petri dishes were incubated in an of the tea tree essential oil with incubator at 370 C for 24 hours. antibiotics decreases the minimum Record of the results was carried out effective dose of antibiotics in the by the diameter of the zones of treatment of infections that reduces growth inhibition around the discs. the adverse effects of antibiotics. For Synergistic effects of the tea tree continuation of these promising essential oil were demonstrated in investigations we need more studies combination with doxycycline, about molecular basis of synergistic ceftriaxon, cefoperason and interactions to understand its ciprofloxacin against both Gram- mechanism of action more and more. positive and Gram-negative bacteria. Besides that the tea tree essential oil

Litvinenko A. POLLUTION OF DRINKING WATER WITH HEAVY METALS SALTS AND REMOVING THEM FROM SOLUTIONS BY MEANS OF NANOCOMPOSITE ZIRCONIUM (ΙV) OXIDE Research advisor: Misnik Olga Department of Bioorganic and Biological Chemistry Bogomolets national medical university Kiev, Ukraine harmful gases emissions to the Actuality. Last years in atmosphere from cars, pollution of Ukraine among the most dangerous the water basin through various environmental pollutants are the harmful and uncontrolled household heavy metal salts, heavy metals wastes reduce the quality of natural themselves, phosphates, nitrates, waters, cause a dysfunction of the nitrites. gastrointestinal tract, nervous and The aim of the investigation immune systems, have a great was to study the increasing of burden on the liver and kidneys, 257

ISIC-2016 Abstract book violate the water-salt balance, on sanitary-chemical indicators. The change the rhythm and the work of obtained results show that the the body. developed methods of performance Matherials and methods. The of heavy metals concentrations scientific data obtained in recent measurements can be applied in years allow to assume that an clinical laboratory practice for both increase of heavy metals emissions the diagnosis of acute poisoning and to the environment is capable of during execution of occupational exerting an immunotoxic effect, to pathological researches because the stimulate the development of cancer main criterion of environmental and autoimmune diseases. quality and ecological safety Results. The increase of heavy indicator is the health of the metals content and their salts in the population. water, the increase of their emissions Conclusion. The presented to the environment, the poisoning of data show that the pollution of soils and food products by them are environmental objects, including the basis for complex researches, an drinking water, by means of salts of application of the modern ways of different metals can have some heavy metal ions extraction and their serious consequences for healthy salts from water solutions by man and points to the need for nanocomposite sorbent "zirconium constant monitoring and adoption of (IV) oxide - activated carbon", the appropriate actions. It is established search for new means of the that the sorption capacity of development prevention of chronic nanocomposite sorbent for Cu2+ is intoxications in the population. 11 mg/g, Pb2+ is 85 mg/g. In the The purification of water samples by work is shown the character of this method gave the results that Cu2+, Pb2+ sorption extraction in allow us to assert the water that was time and that the obtained sorbent purified by these methods not only better removes Pb2+ but is corresponds to all hygienic more selective for it. The sorbent normatives, requirements SSanPiN may be used in water treatment 2.2.4.-171-10 – The state sanitary processes from heavy metals and norms and rules of "Hygienic activated carbon is promising for requirements for the drinking water removing heavy metals ions. intended for human consumption"

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ISIC-2016 Abstract book Medyanik E.A., Boyarskiy O.O. ANALYSIS OF THE IMPACT OF EXOGENOUS FACTORS ON INDICATORS OF KHARKIV NATIONAL MEDICAL UNIVERSITY STUDENT’S HEALTH Research advisor: Reznichenko O.G., asst. Department of Hygiene and Ecology No. 1 Kharkiv National Medical University, Ukraine

Actuality. The problem of the disease in this group was presented student’s health is one of the most myopia. The diseases of the nervous important for society in general and system were on the second place for medicine in particular. College among medical students. So these students are special social groups. ones had 19,33 ± 1,11% boys and Large intellectual stresses, sudden 17,60 ± 1,03% girls, p> 0.05. The changes of a usual way of life, the diseases of the musculoskeletal necessity to adapt to the new system and connective tissue were conditions of intellectual labor, represented mainly scoliosis, flat feet accommodation and food can be and arthropathy. The level of these attributed to the group to a diseases amounted 17,01 ± 1,06% significant risk of disease boys and 15,79 ± 0,98% girls, p> development. 0.05. The chronic diseases of the The aim. To assess the impact digestive system were introduced of exogenous factors on the mainly diseases of the esophagus, indicators of the state of KhNMU stomach and duodenum. The student’s health. proportion of these diseases was Materials and methods. 15,55 ± 0,94% boys and 14,23 ± There were 605 medical students 0,77% girls, p> 0.05. The respiratory under supervision. The health of diseases accounted for 9,02 ± 0,56% students studied on the basis of in- and 10,36 ± 0,67% in boys and girls, depth medical examinations by p> 0.05. Therefore the rate of chronic specialists of the Kharkiv Regional morbidity study group of the student Students' Hospital №20. youth showed no significant Results.The most common differences (p>0.05). In the structure diseases of medical students were of chronic illness on the first place the chronic diseases the eye and there were diseases of the eye and adnexa. So the students values were adnexa, on the second – diseases of equal to 30,14 ± 1,76% boys and the nervous system, the third - 29,02 ± 1,53% girls, p> 0.05. diseases of the musculoskeletal However, among this group of system, the fourth – diseases of diseases prevailed violation of organs of digestion and respiration. refraction and accommodation. More Conclusions.The than 78.89% of medical student’s unsatisfactory health status of

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ISIC-2016 Abstract book students can be associated, organization at the university, the primarily, with violation of the lack of programs to the prevention regime of the day (a shorter night's and correction of the eye pathology sleep, irrational organization mode and other diseases, the level of of work and rest), disorders of medical care to this cohort, and with qualitative and quantitative the careless attitude of students to nutrition, physical inactivity, their health and the presence of inadequate sanitary-hygienic harmful habits. conditions of educational process

Mohamad Sultan, Enemegene Eserogene, Katelevskaya N.M. PREVENTION OF STRESS DISORDERS OF STUDENTS IN MEDICAL UNIVERSITY Department of hygiene and ecology № 1 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. According to the Results. According to poll literature on the health status of the results over 82% of foreign students population in different countries have varying degrees of stress there is present a strong tendency to disorders. Analysis of risk factors of growth psycho-emotional disorders stress among students has shown in young people. that the most important are social The aim. The study of stress factors, such as separation from levels of the foreign students family, change of residence, financial (english-speaking). Rationale difficulties and other. Long-term measures for the prevention of stress stress can cause a lot of physical and disorders in students of Kharkiv mental problems: decreased National Medical University. performance, social exclusion, Materials and methods. chronic fatigue syndrome, Analysis of stress among foreign depression, neurosis, some psycho- students made by examining the somatic diseases, such as literature and a survey of foreign hypertension and other. In some students. The poll involved 135 3rd cases decrease in academic year students of the Medical Faculty. performance also occurs in the stress In the survey, the following methods result. of stress evaluation were used: Scale Conclusion. Prevention of of Holmes and Ray stress, study level stress disorders among university and resistance to stress, students is an important way of questionnaire assessment of maintaining their health and a high personal anxiety by Spielberger. level of assimilation of knowledge. 260

ISIC-2016 Abstract book Nlend Michel Pharrell, Olamaekugbe B., Katelevskaya N.M. RISK FACTORS OF TEEN SUICIDE AS PSYCHO-HYGIENIC PROBLEM Department of hygiene and ecology № 1, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Promoting mental disorders, that contribute to suicide health and well-being, and the attempts. prevention and treatment of Results. Experts point out substance abuse, are integral parts of that suicidal behaviors in young the Sustainable Development Agenda people are usually rooted in multiple to transform our world by 2030 social, economic, medical, familial, adopted by the United Nations and individual risk factors, with General Assembly on 25 September mental health issues playing an 2015. This is recognition of the important role in the overall mix. as importance of these areas of health scientists say, suicide is the result of within global development and a "perfect storm" of complex, health priorities. Especially interrelated psychological problems, important a question of is the many of which are not under the preservation of mental health in the teenager direct conscious control. case of the discussion of mental Especial risk group are adolescents health and the causes of teen suicide. with borderline mental health Suicide is the second leading cause of problems such as chronic stress and death among 15–29-year-olds depression. An aggravating factor is (WHO). that in the age of 11-15 years old The aim. Study of risk factors teenagers undergoing major of teen suicide and methods of hormonal changes and accelerating prevention of mental disorders that growth. contribute to suicide attempts. Conclusion. Identification Materials and methods. In and ccorrection of specific psycho- our work we carried out the emotional risk factors of suicide for analytical study and generalization the mental health of modern of modern data published about teenagers is an important direction problem of the teens suicide and of psychohygiene. methods of prevention of mental

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ISIC-2016 Abstract book Obinyan Ofure Abigael SCHISTOSOMIASIS EPIDEMIC IN NIGERIA Research advisor: professor ChumachenkoTatyana Department of Epidemiology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Schistosomiasis, presentations of 3.7% hepatomegaly, also known as snail fever, is a disease 7.4% splenomegaly, 12.3% caused by parasitic flatworms called periportal fibrosis and 6.3% schistosomes. The disease is spread schistosomal appendicitis. by contact with fresh water Appendicitis is the most common contaminated with the parasites. The childhood pathology that requires disease is especially common among surgery. In a case such as children in developing countries as schistosоmal appendicitis which they are more likely to play in could be adequately prevented, contaminated water. Other high risk having such a high percentage of groups include farmers, fishermen, children infection is of and people using unclean water epidemiological significance to the during daily living. It belongs to the society. Having a large at risk group group of helminth infections. of children between the ages of 5-10, Schistosomiasis is of epidemiological inhibits the children from going to importance in Nigeria because the school while they are infected and two known human forms of without an education, most of the schistosomiasis ie S.haematobium children are unable to break the and S. mansoni, are currently endless cycle of economic hardship. widespread throughout the country Conclusion. Prevention and and also because the highest adequate treatment of prevalence of infection within Sub- Schistosomiasis is the only way of Sahran Africa is seen in Nigeria. inhibiting the complications that can Aim. The aim of this abstract is occur due to the infection. While the to identify the complication rate of government and Non-Governmental Schistosomiasis and the effect of Organization (NGO) partners have such complications. already taken several steps to Materials and methods. Data address the burden of disease, of World Health Organization and comprehensive epidemiological World Bank were used and analyzed. mapping had not been available until Result. The estimated recently. Moving forward, the prevalence of infection seen in Federal Ministry of Health has Nigeria is 29 million people infected, recommended that all levels of out of which S.mansoni is the chief government (Federal, State and Local cause of clinical abnormalities with Governmental areas), Neglected

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ISIC-2016 Abstract book Tropical Diseases (NTD) partners and sanitation provisions. Plans and other stakeholders, to scale up should also be put in place for impact uninterrupted provision and assessment after the third year of administration of appropriate consistent mass administration of medicines alongside other treatment. environmental improvement interventions such as clean water

Otaigbe P.A., Goodlite S.N. PSYCHOHYGIENIC ASPECTS OF TEST ANXIETY AT MEDICAL STUDENTS Research advisor: Gerasimenko O.I., PhD Department of Hygiene and Ecology No. 1 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Test anxiety is stay mentally and physically alert. typical for the student populations of When one experiences too much the world. It is a physiological anxiety, however, it can result in condition in which people emotional or physical distress, experience extreme stress, anxiety, difficulty concentrating, and and discomfort during and before emotional worry. Inferior taking a test. In psychohygiene we performance arises not because of understand it as a combination of intellectual problems or poor physiological over-arousal, tension academic preparation, but because and somatic symptoms, along with testing situations create a sense of worry, dread, fear of failure, and threat for those experiencing test catastrophizing, that occur before or anxieties. during test situations. This anxiety The aim of our research is to creates significant barriers to determine evidence of test anxiety in learning and performance. Research English medium students who study suggests that high levels of in KhNMU. emotional distress have a direct Material and methods. It was correlation to reduced academic used Learning Questionnaire performance and higher overall (MSLQ), we analyzed 97 personality student drop-out rates. Test anxiety research forms of 3d year students of can have broader consequences, Medical Faculty of (58 % male and negatively affecting a student's 42 % female) with an age of 19-23 social, emotional and behavioral years. The majority of the development, as well as their feelings participants were from India (48 %) about themselves and school. Some and Africa (30 %); the remaining anxiety is normal and often helpful to participants came from Israel, 263

ISIC-2016 Abstract book Palestine, Lebanon and other quite (36 % have low level of countries. anxiety). Results. According to results Conclusions. Increasing of our studies, most of 3d year anxiety resulting from the sense of students respondents (64.2 %) threat then disrupts attention and showed average level of test anxiety. memory function. Founded features Highest level of this characteristic of test anxiety evidence allowed was inherent for Arabian girls (4.26). proposing some directions of self- In another national and sex groups regulation for students with high results were similar (from 3.5 at level of uneasiness. This program Indian boys up to 3.99 at African includes special physical exercises, girls). Comparative analysis showed well-balanced meal excluding that girls in all groups worry more caffeine, alcohol and food with high about results of their academic sugar content, and psychohygienic performance (4.03 to 3.67 at boys). techniques for relaxation before test African students-boys were more and reinforcement memory during it.

Vladislava Sarkis-Ivanova, Andrey Sokoltsov, Yegor Buzevich ANTIBIOTIC RESISTANCE OF PSEUDOMONAS AERUGINOSA STRAINS AS A CRITERION OF ASSESSMENT PUBLIC HEALTH REGIMEN OF MEDICAL PREVENTIVE INSTITUTIONS Kharkiv national medical university (Department of Hygiene and Ecology No.1), Kharkiv, Ukraine

Relevance: The development of many serious consequences (e.g. anesthesiology and intensive care units complications, lengthening hospital as well as the increasing the stay, increase in expenses), and causes capabilities of surgical treatment and higher mortality than community- the introduction of new invasive acquired infection. In the majority of methods of diagnosis and treatment in cases, the reason is Gram-negative health care institutions increases the bacteria among other things incidence of nosocomial infections. Pseudomonas aeruginosa (Р. This phenomenon is spread in various aeruginosa). One of the characteristics hospital environments, and leads to of nosocomial infections that is highly 264

ISIC-2016 Abstract book resistant to the majority of hospitals cephalosporins- aminoglycosides- antibiotics. fluoroquinolones (profile of antibiotic Aim: The major aim of this resistance– CFTPMGAN). Selected study was to determining sensitivity of strains might be the main cause of Р. aeruginosa strains to different groups nosocomial infections in city’s of antibiotics. The twenty strains were hospitals. isolated from environmental objects of Conclusion: Considering the surgical departments and intensive care wide prevalence and clinical units. importance of P. aeruginosa isolates Materials and methods: In this using of appropriate infection control cross-sectional study, P. aeruginosa measures as microbiological isolates were collected from different environmental monitoring is necessary clinical specimens. Antimicrobial to prevent further spread of infections susceptibility was done against Р. by these resistant organisms. These aeruginosa strains by disk diffusion data may serve to M. D. for scheming test. The results analyzed by software antibiotic treatment in different application WHONET 5.1. hospitals. Consequently, it is necessary Results: Profiles of resistance in to strict monitor the antibiotic major cases were varied, that probably resistance of circulating strains and indicate to accidental contamination of committed to methods of balanced environmental objects. Although, data antibiotic therapy in the medical varied between strains, four strains had preventive institutions. the highest drug resistance to

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ISIC-2016 Abstract book Singh Shivam, Vasava Prashant PSYCHOLOGY AS A MEDICAL INSTRUMENT IN STRUGGLING WITH DEPRESSION Research advisor: Nesterenko Anastasiia Department of Ukrainian language, principles of psychology and pedagogics Kharkiv National Medical University

Actuality. The topicality of the behavior, feelings and sense of well- problem is caused by different being. It is a serious condition that factors presented in different fields affects your physical and mental of life. Today’s world is characterized health. by the presence of race education. It In clinical psychology the means that students may appear psychological science integrate with under a strong pressure of marks the treatment of complex human and ratings. That can lead a person to problems. These problems are depression. And psychology is mainly related to their past. It is important for such people to help proved that psychological problems them in struggling with depression occur mainly when a person is faced and decreasing harm of their hilarious tragedy in the past which mentality. Thus, psychology becomes can’t be healed out yet now. So such a medical instrument. Psychological people have to be given a special science is also important in medicine type of treatment (not only medical, when we need to promote health, but also psychological ones) so that improve health care or prevent they get out of depression. According illness. to different researches the best kinds The aim. So, our goal is to of such psychological treatments are study psychology as a medical sharing feelings, making good instrument in struggling with friendship, spending lot of time with depression. the person and make him / her Results. According to happy. scientists, in medicinal field That is why psychological science psychological profession is becoming unveils new and very important way primary care setting. Like some are for people to exist and thrive in this more and more getting used to today’s new world. smoking, drugs and alcohol, eating Conclusion. So, in our opinion, disorder and disability, depression is psychology is necessary in all also the main psychological problem. professions. It plays very important Depression is considered as a state of role in our life, especially in such its low mood and aversion to activity fields like education (where it can that can affect a person's thoughts, improve our brain mentally and also

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ISIC-2016 Abstract book retain knowledge), health, conditions. Thus, psychology is a psychological knowledge, etc where powerful medical instrument that it helps people not just to adopt in must be used not only by doctors but different conditions but also to also by every person who thinks of struggle with diseases (e. g. other’s health. depression) caused by these

Tinuola Olajide, Andikan Udoh Effiong, Olga S. Sasina PSYCHO-HYGIENIC HEALTH RISK FACTORS OF CHILDREN AND TEENAGERS WITH VISION PATHOLOGY Department of hygiene and ecology № 1 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. An estimated 19 children and teenagers with vision million children are visually pathology. impaired. Of these, 12 million Results. The study children are visually impaired due to environment for visually impaired refractive errors, a condition that adolescents shows to perfectly could be easily diagnosed and ensure correct and complete corrected. 1.4 million are irreversibly acquisition of knowledge is blind for the rest of their lives and necessary to provide a good psycho- need visual rehabilitation emotional climate. Schools are interventions for a full psychological adapted to physical assist children and personal development (WHO). and teenagers with visual Children should all be able to achieve pathologies. Safety considerations their optimal physical growth and are a priority. Class rooms are psycho-emotional development, organized so that the students can even if they have certain features of know just where to go for what they development, such as diseases of the require. The learning environment view that lead to blindness or has a sufficient set of tools for deterioration in vision function. acquiring knowledge, such as: Braille The aim. Study of psycho- code, tactile graphic and tactual hygienic health risk factors of books. They are designed to ensure children and teenagers with vision that the students effectively acquire pathology. knowledge without limitations. But, Materials and methods. In unfortently, level of psycho- our work we carried out the analysis emotional help is low. and generalization of data published Conclusion. Identification of on the problem of the proper mental specific psycho-emotional risk and physical development of factors for the health of children with 267

ISIC-2016 Abstract book pathology of vision is an important direction of hygiene.

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ISIC-2016 Abstract book

SURGERY

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ISIC-2016 Abstract book Ahmed R.B. DIFFERENT MANAGEMENT APPROACHESFOR PATIENTS WITH PANCREATIC TRAUMA Research advisor: Teslenko S.N., Professor Kharkiv National Medical University Department of surgery, Kharkiv, Ukraine

Actuality. Pancreatic trauma 5 patients in grade 4 with proximal occurs in approximately 4% of all transection of the pancreas and also patients sustaining abdominal involvement of the ampulla, and 3 injuries. Most patients with patients in grade 5 with massive pancreatic trauma have concomitant disruption of the pancreatic head. injuries. The pancreas has an Each group of patients had different intimate relationship with major clinical manifestations from mild to abdominal vessels, and there is severe. Patients in grades 1&2 were significant morbidity and mortality relatively satisfactory with rate associated with severe nonspecific symptoms, while pancreatic injury.Pancreatic injury patients in grades 3-5 had symptoms occurs infrequently after blunt or like flank ecchymosis, jaundice, back penetrating abdominal trauma and pain. so many conservative and surgical Results. Based on the degree of approaches have been introduced for manifestations, all 40 patients were its management. treated differently. Patients in grade The aim. To assess the efficacy 1 and grade 2 were treated with non- of different tactics in management of surgical methods because of absence patients with pancreatic trauma of involvement of the pancreatic depending on the grade and its duct. Debridement and drainage was location. carried out for these patients. Closed Materials and methods. The suction drains wereused for the study included 40 patients with above patients, other non-operative pancreatic trauma. According to the management introduced were; severity of the trauma the patients bowel rest and total parenteral were divided into five grades using nutrition. These management American Association for the Surgery strategies proved effective. Patients of Trauma (AAST). 15 patients in who were classified into grade 3, grade 1 with minor contusions grade 4 and grade 5 required a without duct injury, 10 patients in different management strategy due grade 2 with major contusion to the involvement of pancreatic without any duct injury or tissue duct, laceration of the ampulla and loss, 7 patients in grade 3 with massive disruption of the pancreatic laceration and pancreatic duct injury, head. In these patient the therapeutic

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ISIC-2016 Abstract book approach given was drainage and from grades 1 and 2 had absolute surgery. Patients in grade 3 were recovery with no complications. treated with distal pancreatectomy About 80% of patients from grades 3, performed, while patients in grade 4 4, 5 recovered within 4-5 days, 10% and 5 underwent drainage and of the patients had pancreatic fistula Whipple procedure. and the other 10% had pancreatic Conclusions. From our study, pseudocysts as complications. after different management, patients

D.Yu Artemchuck, scientific director Ph.D. V.Yu. Shapovalov LAPAROSCOPY IN DIAGNOSIS OF ACUTE APPENDICITIS Odessa national medical university (Department of general surgery and military medicine, Odessa, Ukraine)

Actuality. Onset of using laparoscopy made better quality of the diagnosis and results of acute appendicitis treatment. According to the data of World Health Organization about 30 % of the inpatient department patients have combined pathology of the abdomen cavity organs. Frequency of the detection of simplex (superficial) appendicitis during traditional appendectomy – 40%. Aim of this study was to evaluate laparoscopy in diagnosis of acute appendicitis. Materials and methods. In our clinical investigation 251 patients with suspected acute appendicitis were operated by using of videolaparoscopy techniques. In case of determined acute appendicitis laparoscopic appendectomy was carried out. Results. We managed to inspect appendix in 99.6% cases during laparoscopy. In one case we couldn’t detect it because of expressed peritoneal commissures after the previous operations. In 42(16.7%) diagonsis of acute appendicitis were excluded during the diagnostic stage of laparoscopy because of determine another diseases of abdomen cavity or appendiceal mass. Operation ended by diagnostic laparoscopy in 8 cases of them, in 34 cases diagnostic laparoscopy came into therapeutic for another abdomen pathology. Only one patient underwent removing of the non-inflamed appendix during laparoscopy, it compound 0,4%. During the traditional open surgery quantity of the removing of non-inflamed appendices was 6,5%, what confirm that laparoscopy is more effective. Frequency of the detection of simplex appendicitis who was operated laparoscopically less than such patients with open surgery reciprocally 10,5% and 36,4 %.

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ISIC-2016 Abstract book Conclusions. Videolaparoscopy allows to determine the diagnosis of acute appendicitis, diagnosis of another diseases of abdomen cavity and to avoid ineffectiv appendectomy in 6,5%.

Basylaishvili S. MORPHOLOGICAL EVALUATION OF NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH LUNG CANCER Research advisor: Starikov V.I., Doctor of medicine Kharkiv National Medical University Department of Oncology, Kharkiv, Ukraine

Actuality. At stage 3A lung a significant suppression of the cancer (LC), two cycles of mitotic activity of up to 4,5‰ and neoadjuvant chemotherapy (NCT) 100% of pathological mitosis. are recommended by the standard of However, along with the destructive care. However, often there is no changes there are extensive solid objective effect. At the same time fields with practically unaltered or introduction of NCT postpones terms little modified tumor structure and of radical surgery performance and high mitotic activity 17‰ and up to deteriorates the patients' condition. 41.14% of abnormal mitosis. In The aim. To study therapeutic general, after NCT only 34% of pathomorphosis in tumors of patients had moderate therapeutic patients with lung cancer who damage of tumor. In the tumor received NCT followed by surgery. appear uneven decrease in Materials and methods. For parenchyma volume and clearly morphological studies we used visualized laminating tumor histological specimens from 27 monolith, islets of connective tissue, patients aged from 46 to 68 years old of already tumor stroma. males, in whom the first stage of Conclusions. Therapeutic treatment was chemotherapy. Before pathomorphosis of lung cancer after surgery they received 2 cycles of chemotherapy is characterized by a NCT (cisplatin 70 mg/m2 body low degree of damage at the cellular surface area on the first day, and tissue levels with increasement etoposide 120 mg/m2 on 1-3 days in the number of pathological mitosis i.v.) with 3 week intervals. in a stable mitotic index, activation of Results. After chemotherapy in local stromal immune responses and tumors develop irregular atrophic apoptosis. This explains the lack of and degenerative processes, clinical benefit from NCT in the represented by foci of regression, majority of patients with lung cancer, necrosis and their organization with 272

ISIC-2016 Abstract book and casts doubt on the feasibility of its implementation.

Bilchenko Sofiia CORNEAL CHANGES AFTER THE NON PENETRAITING DEEP SCLERECTOMY AMONG PATIENTS WITH GLAUCOMA AND DIABETIC POLYNEUROPATHY Kharkiv National Medical University Ophthalmological department Scientific supervisor: Zavoloka Olesya

The risk of resistant glaucoma cornea was decreased 7 days after development is increased in patients surgery, was not statistically with diabetes mellitus that often changed 14 days and was increased leads to the surgery. It is known that 1 month after the nonpenetraiting vegetative nervous fibers influence deep sclerectomy in comparison on the corneal neurotrophical state. with the data before surgery (р=0.02 Diabetic patients suffer from an early and р=0.04). In patients with affect of sensitive and vegetative glaucoma the sensitivity of the nervous, that can cause a change in cornea was not statistically changed epithelization of incision after a non 7 days and increased 14 days and 1 penetraiting deep sclerectomy in month after the surgery (р=0.02 and patients with glaucoma. р=0.01). patients with glaucoma and The aim was to study the diabetic polyneuropathy 7 days after corneal neurotrophical state after surgery, were not statistically the non penetraiting deep changed 14 days and increased 1 sclerectomy among patients with month after the nonpenetraiting glaucoma and diabetic deep sclerectomy in comparison polyneuropathy. with the data before surgery (р=0.03 Methods. 30 patients with and р=0.04) not statistically changed glaucoma and diabetic patients with glaucoma 7 days and polyneuropathy and 30 patients with 14 days after surgery, and increased glaucoma without diabetes mellitus 1 month after the nonpenetraiting were made the non penetraiting deep sclerectomy in comparison deep sclerectomy. Research methods with the data before surgery (р=0.04 were Corneal Confocal Microscopy, and р=0.02). esthesiometry, pupil cycle time, Conclusions. In patients with Schirmer’s, Jones’ and Norn’s test. glaucoma and diabetic They were under supervision during polyneuropathy the neurotrophical 1 month. corneal changes are noted after the Results. In patients with nonpenetraiting deep sclerectomy. glaucoma and diabetic The sensitivity of the cornea, polyneuropathy the sensitivity of the common tear production and tear

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ISIC-2016 Abstract book film break-up time are decreased 7 days after surgery.

Bohdanets O., Ivachnova K., Novikova K. THE CONTENT OF FAS LIGAND IN PRIMARY OPEN ANGLE GLAUCOMA Research advisor: Panchenko M. V., Professor Kharkiv National Medical University Department of ophthalmology, Kharkiv, Ukraine

Actuality. Glaucoma is a group glaucoma is below the detection level of eye diseases characterized by an (Borkenstein et al.; 2013).For the increase in intraocular pressure results of other scientists research resistant to the subsequent findings suggest that patients with development of the visual field suspected glaucoma, increased defects, decreased visual acuity and secretion of sFas /Apo-1 in the tear optic atrophy. Glaucoma may result fluid, with a lower concentration of from apoptosis. Fas ligand - such blood serum, at relatively cytokines, which triggers a cascade moderate levels sFasL in tears, and of biochemical reactions, which is the the absence of it in the serum . The final stage of defragmentation of progression of the disease, for their chromosomes and cell death. information, associated with the The aim. To study the weakening of both sFas / Apo-1 and literature on the content of FAS sFasL, reflecting the propensity to ligand in primary open angle "deplete" Fas - mediated apoptosis glaucoma. level and possible transition to the Materials and methods. The next phase of the apoptotic process review of works of scientists with the other markers (Slepova OS, engaging in determination of Fas et al .; 2012).Results are available for ligand in the aqueous humorof front researchers who also confirmed on chamber of eye at POAG from 2007 the influence of Fas markers - to 2013 was conducted. mediated apoptosis in the Results. The results obtained development of the disease , they say that the level of Fas ligand in patients that signs risk of POAG is the spot " withPOAG, pseudoexfoliative hypersecretion » sFas / Apo- 1 (as glaucoma and cataract groups were compared to the system ) and the not significantly different apparent prevalence it over sFasL in (Razeghinejad MR, et al .; 2007). For the tear fluid , also an unfavorable the data of other authors Fas ligand sign of the disease is considered in the aqueous humor of the anterior strengthening local and system sFasL chamber in patients with open-angle secretion and smoothing the gap

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ISIC-2016 Abstract book between the content of sFas / Apo- 1 consensus on the role of FAS ligand in serum and tear ( Frolov, MA, et al , in primary open angle glaucoma that 2012 ). demonstrates the need for further Conclusions. The study research. showed the absence of scientific

Borachok T., Kopanska D. IMPACT OF PREOPERATIVE FASTING TIMES ON BLOOD GLUCOSE, KETONE BODIES AND ACID-BASE BALANCE IN CHILDREN YOUNGER THAN 36 MONTH Research Advisor: Assistant Svitlyk Y. Lviv National Medical University Lviv, Ukraine

Actuality. Preoperative fasting observational study, all of them in a is important to reduce the risk of stable haemodynamic condition. regurgitation and pulmonary Children who received intravenous aspiration of gastric contents in fluids during the fasting period, were children undergoing anaesthesia. For admitted to critical care, experienced children, the preoperative fasting nausea and vomiting, or had a guidelines published by the Amer- metabolic disorder were excluded. ican Society of Anesthesiologists The study was conducted from June (ASA) and European Society of 2015 to November 2015 in the Anaesthesiology (ESA) allow clear Pediatric Clinic “OHMATDYT”, Lviv, fluids up to 2 h, breast milk up to 4 h Ukraine. As a routine, the ward staff and other milk and solids up to 6 h were given written individual before induction of deep sedation or instructions for fasting times before general anaes-thesia.1,2 However, the estimated time of induction of actual fasting times in children are anaesthesia according to the often longer than recommended and institutional guideline: 6 h for solid many children suf-fer from a foods, 4 h for breast milk or infant considerable amount of preoperative formula, and 2 h for clear fluids discom-fort because of excessive (apple juice or sugared tea). After fasting times. induction of anaesthesia, a venous Materials and methods. 100 blood sample was collected routinely children aged 0–36 months from all children. Ketone bodies less scheduled for elective paediatric than 0.6 mmol/l were accepted as surgery were included in this normal and hypoglycaemia was prospective, noninterventional, 275

ISIC-2016 Abstract book defined as glucose concentration less (for each, P < 0.05), but not glucose than 2.8 mmol/l. or lactate. In children with DGL more All recorded data were than 2 h (54%), ketone bodies, analysed using MS Excel and Medcalc osmolality and anion gap were Statistical Software and presented as significantly higher and base excess mean values standard deviation (SD) significantly lower than children (range) or frequency. Wilcoxon test, with DGL less than 2 h (for each, P < Mann–Whitney test and linear 0.05). regression analysis were performed Conclusion: After prolonged for metric data with a predefined sig- preoperative fasting, chil-dren nificance level of a equal to 0.05. younger than 36 months can present Results. Mean fasting period with ketoacidosis and (low) normal was 7.8 - 4.5 (3.5 to 20) h, and blood glucose concentrations. Actual deviation from guideline (DGL) was fast-ing times should be optimised 3.3-3.2 (-2 to 14) h. Linear regression according to existing guide-lines. In showed a significant correlation small infants, deviations from fasting between fasting times and ketone guidelines should be as short as bodies, anion gap, base excess, possible and not longer than 2 h. osmolality as well as bicarbonate

Boyarskiy A.A. THE ASSESSMENT OF THE EFFICIENCY OF USING THE TRAM-FLAP ON THE NUTRIENT PEDICLE AS THE BREAST RECONSTRUCTION METHOD Research Advisor: Beliy A.N., PhD, Associate Professor Kharkiv National Medical University Department of Oncology, Kharkiv, Ukraine

Actuality. Breast cancer (BC) radical removal of the tumor, but it occupies a leading place in the brings physical and mental suffers to structure of women’s oncological the patient. And due to the fact that morbidity. The success of BC BC occurs in women of reproductive treatment depends on many factors, age in 20% of cases, one of the among which the main role belongs important issues in the treatment of to the time of treatment’s beginning, this disorder is to restore the breast. the histological features of the tumor The most common method is to wear and the extent of its distribution. The a special underwear. But this method main part of the BC treatment is the has several disadvantages, especially surgical one. It is used a radical among young patients: inability to mastectomy in the vast majority of wear a deep neckline and swimwear, cases. This operation provides a a sense of inferiority in the absence 276

ISIC-2016 Abstract book of this bra, so women are offered the group according to the information breast reconstruction. There are the of literature. This complication was following reconstructive operations: noted only in 2 patients. Seroma was dermotension with subsequent detected in 1 patient. Regular arthroplasty, thoracodorsal flap + puncture under ultrasound helped to implants, TRAM-flap on the leg of the cure it without suppuration. rectus abdominis, TRAM-flap on the Postoperative hernias were noted. free microvascular anastomoses, Patients used a three-dimensional plastic free vascular grafts on tattoo to restore the appearance of microvascular anastomoses. the nipple-areola complex. Periods of The aim. The aim of this work observation all the patients after the is the assessment of the efficiency of operation is 1-2 years. They received TRAM-flap on the nutrient pedicle adjuvant treatment according to the transplantation, as one of the most protocol after the operation. physiological methods. Prolongation of the disease in this Material and methods. We group of patients is not yet marked. performed the TRAM-flap on the Conclusion. Thus, using of nutrient pedicle transplantation 12 TRAM-flap for the breast patients aged under 55 years with reconstruction after radical stage 1-2 BC. We made them directly mastectomy is a perspective and safe after radical mastectomy. method, but we should remember Results. 40% of patients were that every patient needs a smokers, however, we have not comprehensive and individual received the expected high percent approach. of flap marginal necrosis in this

Davydych Alina PATHOGENETIC ASPECTS OF DRY EYE SYNDROME IN SJOGREN'S DISEASE Research advisor: Ilyina Y.N., Kharkiv National Medical University Department of Ophthalmology, Kharkiv, Ukraine

Introduction: The increasing the basic pathogenetic links of the amount of patients with the syndrom process with this systemic disease is of dry eye is admited during last topical. years .27-29% are patients with The aim: To improve the Sjögren's syndrome (by statistics). In differential diagnostics of dry eye the literature, there is a few syndrome in Sjogren’s disease by information about this syndrome, studying development mechanisms that is why it is the specification of of this disease. 277

ISIC-2016 Abstract book Materials and methods: production of mucins and dryness of Analysis of reviewed literature of the mucous membranes, namely the last 5years. A retrospective analysis mucin layer of the lachrymal film; of medical records of Kharkiv Regional Clinical Hospital, Center of • 50-100% patients with Emergency Medical Care and autoimmune liver disease (Anti- Disaster Medicine. We have studied Ro/SSA and anti-La/SSB, antibodies 73 case histories of patients with directed against Ro/La Sjögren's syndrome. ribonucleoprotein complexes, can Results: As a result of research serve as a diagnostic hallmark of such information was obtained: Sjogren’s syndrome. Comes out as Sjögren's syndrome arises up at: the lesion of lacrimal glands and, • 15-25% patients with reumatoid consequently , it violates their arthritis; secretory function . Reduced • 5-10% patients with collagenoses; production of tears and mucins. As a Sialoschesis occurs due to result of impaired stability autoantibody production to M3 precorneal lachrymal film , its muscarinic receptors, which are strength is reduced, evaporation is involved in the transmission of nerve increased, which leads to the impulses required for the synthesis development of xerosis.); of aqueous saliva component and • 50-70% heredity (in families with tears, as well as increased content of different autoimmune and proinflammatory cytokines - IL-1, connective tissue diseases); which leads to a compensatory Conclusion: Updated production of IL-1RA and it causes information about the development inflammation and oral mucosal of dry eye syndrome in patients with dryness and its activation triggers Sjögren's syndrome. So , there is a the proliferation of B-lymphocytes, decrease production of the mucin which induces apoptosis in epithelial layer of the lachrymal film and cells and affects the salivary glands, aqueous component as a result of causing dry mouth. systemic connective tissue diseases , • 50-60% postclimacteric women (in autoimmune diseases , hereditary the women’s body decreases and post-menopausal. estrogen levels, which leads to lower

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ISIC-2016 Abstract book Duras Anastasia, Baraniuk Mariia ULTRASOUND BIOMICROSCOPIC FEATURES OF PIGMENTARY GLAUCOMA

Kharkiv National Medical University Ophthalmological department Kharkiv, Ukraine Scientific supervisor: Duras Inna

Introduction In pigment using ultrasound biomicroscopy. dispersion syndrome, friction Interventional case series. between the posterior iris surface Methods Ultrasound and the anterior zonular bundles biomicroscopy was performed on causes the disintegration of iris both eyes of 23 patients with pigment epithelial cells and the asymmetric pigment dispersion release of pigment granules, which syndrome without a known cause for are then dispersed by aqueous asymmetric involvement. A radial currents. The liberated pigment is perpendicular image in the deposited throughout the anterior horizontal temporal meridian segment. The classic diagnostic triad detailing the scleral spur, angle consists of a Krukenberg spindle, anatomy, and iris configuration was slitlike radial midperipheral iris obtained for each eye. transillumination defects, and Results There were no increased pigmentation of the differences in lens thickness, trabecular meshwork. The angle is refractive error, or axial length typically wide open, the iris is between more and less affected eyes. inserted posteriorly, and the However, iris concavity, iris-lens configuration of the peripheral iris is contact distance, and distance from posteriorly concave. Elevated the scleral spur to the iris insertion intraocular pressure develops in were greater in the more affected many patients and may lead to eye of each patient. glaucomatous damage (pigmentary Conclusion A more posterior glaucoma). iris insertion predisposes to the Purpose To examine patients phenotypic expression of pigment with pigmentary glaucoma or dispersion syndrome. pigmentary dispersion syndrome

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ISIC-2016 Abstract book Duras Anastasia, Aksjonova Nadiia CHANGES IN THE ANTERIOR CHAMDER AFTER PHACOEMULSIFICATION CATARACT

Kharkiv National Medical University Ophthalmological department Kharkiv, Ukraine Scientific supervisor: Duras Inna

PURPOSE: To report cornea, AOD250, AOD500, and quantitative changes in the anterior trabecular-iris angle increased chamber configuration after small- significantly after surgery. The incision cataract surgery with preoperative anterior chamber implantation of a posterior chamber depth at the center of the cornea and intraocular lens by means of trabecular-iris angle were negatively ultrasound biomicroscopy. correlated with the differences METHODS: We examined the between the postoperative and anterior chamber configuration of 12 preoperative values. The eyes of 12 patients before and 3 preoperative values of all variables months after phacoemulsification examined were negatively correlated cataract surgery plus intraocular with the ratios of the postoperative lens implantation by ultrasound value to the preoperative value. biomicroscopy. The following CONCLUSIONS: The present variables were measured: the results showed that small-incision anterior chamber depth at the center cataract surgery significantly of the cornea, the angle-opening deepened the anterior chamber and distance 250 μm from the scleral widened its angle. The more shallow spur (AOD250), the angle-opening the preoperative anterior chamber distance 500 μm from the scleral was, the greater the postoperative spur (AOD500), and the trabecular- change of the chamber was; and the iris angle. more narrow the preoperative angle RESULTS: The anterior was, the greater the postoperative chamber depth at the center of the change of the angle was.

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ISIC-2016 Abstract book Elena Fundovna, Ilyina Yevgeniya COMPARATIVE CHARACTERISTICS OF THE EFFECTOF LUMINESCENT AND LEDLIGHT ON THE ORGAN OF VISION Kharkiv National Medical University Department of Ophthalmology, Kharkiv, Ukraine

Actuality. Natural daylight is was equal to 1,0 ± 0,1 and 1,0 ± 0,3, the most physiological illumination respectively, in groups with for our eyes. However, in the age of luminescent and LED light, p = 0,16. technological progress the The amplitude of accommodation in importance of using artificial light the beginning of the study in the LED cannot be understated. On this basis group was 9,63 ± 0,02 diopters, after it isrelevant to examine the extent of 6 months of the study it coincided the pathological effects of 9,76 ± 0,04, p = 0,14. In the group of luminescentand LED light on the young people who used the eyesight. luminescent light its value was equal The aim. To study and to to 9,62 ± 0,34 diopters and 9,86 ± compare the influence of 0,24 respectively in the beginning luminescentand LED illuminationon and after 6 months of the study, p = the accommodativesystem. 0,20.While normal values are 9,47 ± Materials and methods. 0,02 diopters and 10,16 ± 0,12. The Literature data. The authors have coefficient of the ciliary muscle been conducting a study on 63 fatigue was 7,40 ± 4,37 in the LED volunteers who were 20-25 years old group and 8,34 ± 0,36 in with normal vision or with its theluminescent group equally at all spectacle correction for 6 months. stages of observation, p = 0,06, at a The volunteers were divided into 2 rate of up to 10,7 ± 4,8. Intraocular groups: 31 and 32 people. The first pressure before the study was 17,3 ± group was exposed to LED lighting, 1,1 mm Hg, after the completion of the second – luminescent light for 7- study - 17,6 ± 1,1 mm Hgin the group 8 hours a day. Visual acuity, the of volunteers using LED, p = 0,26 and amplitude of accommodation, fatigue 17,70 ± 1,1 mm Hgduring the entire factor of the ciliary muscle and the period of observation from persons intraocular pressure were applying luminescent light, p = 0,61 measured.Biomicroscopy was (at a rate of 9-21 mm Hg). By means performedto inspect the anterior eye of biomicroscopy and segment.The posterior eye segment ophthalmoscopy no pathology was was visualized with ophthalmoscopy. detected. Results. Visual acuity before Conclusion. During the and after the study did not vary applying of luminescent and significantly, and the average value LEDlightingfor 6 months the change

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ISIC-2016 Abstract book in visual acuity and accommodation Dynamics in the rate of volume did not occure. exhaustion of the ciliary muscle is In this case, the absolute value absent, which means the beneficial of the accommodation increases, effect of the two types of lighting. which gives an indication of Negative effect on intraocular decreasing its voltage while working pressure have not been identified. with the luminescent lighting.

Galkina Karetyna, Samoilenko Svetlana, Nikolaenko Alina THE EFFECTS OF PHYSICAL ACTIVITIES ON THE GLYCEMIA LEVELS OF CHILDREN WITH THE DIABETES MELLITUS Research advisor: Assistant Morozov Oleksandr Volodymyrovych Department of Physiological Pathology Kharkiv National Medical University Kharkiv, Ukraine

Aim: To estimate factors that 3 groups due to their PA levels: 1 - have influence on glycemia changes with low PA level (n=5); 2 - with within children and adolescents with moderate PA level (n=14); 3 - with type 1 diabetes mellitus (DM). high PA level (n=6). Glycemia levels Materials and methods: were measured before and after During performance of work in standard moderate physical. Patients Endocrinology department of GT were divided into two groups "HICA NAMS" 25 children and depending on the glycemia level adolescents with type 1 DM were before physical exercises (A - under examined. There were 10 boys and 15 mmol/l, n=14; B - over 15 15 girls among them, all of 9-16 mmol/l, n=11). Statistical data years old and 2-8 years of disease processing was carried through duration. The questionnaire used to using Excel software package. define initial level of physical activity Results: Our research revealed (PA) was based on the two leading that most patients' glycemia levels foreign questionnaires (International decreased (by 1,7-9,2 mmol/l) in Physical Activity Questionnaire and response to standard complex of Physical Activity Questionnaire for physical exercises of moderate Older Children and Adolescents), intensity. Only 3 of 25 patients changed and adapted to the (12%) had their glycemia levels conditions. PA was evaluating during slightly increased (by 0,9-1,8 7 days considering activities during mmol/l) with no relation to its initial classes, after classes and on levels. According to test data high PA weekend. Patients were divided into level was accompanied by lower 282

ISIC-2016 Abstract book glycemia indexes (10,2±1,3 mmol/l) patients' sex. Similar changes were as compared with the results of observed also in groups with groups with low and moderate PA moderate and low PA, among which (13,7±1,1 mmol/l and 13,7±0,8 the most decrease of glycemia levels mmol/l, p<0,05). Glycemia levels in was shown in group A (5,1±0,6 boys tend to decrease more than in mmol/l). girls (5,5±1,3 mmol/l compared to Conclusions: The dynamics of 2,8±0,6 mmol/l, p<0,05), initial glycemia levels change in children glycemia levels being the same. The with type 1 DM exposed to physical revealed tendency was also shown in exercises depends on sex, initial cases of moderate glycemia levels - glycemia level and general physical 5,8±1,3 mmol/l in boys and 2,8 activity. Thus we can distinguish mmol/l in girls (p<0,05). Glycemia groups of patients with high levels in the group of patients with hypoglycemia risk, especially boys higher initial levels of glycemia with initial normoglycemia and high (group B) have shown to decrease level of physical activity. more significantly regardless of

Gillies N.P. MANAGEMENT OF PREMATURE EJACULATION CONCERNED WITH COMPARISONS OF PHARMACEUTICAL AND THERAPEUTIC MANAGEMENT VERSUS SURGICAL INTERVENTION Research Advisor: Knigavko A.V., PhD, Associate Professor Kharkiv National Medical University Department of Urology, Nephrology and Andrology Kharkiv, Ukraine

Actuality. Although clinical The aim. The primary practice shows an apt to employ objective of this study was to parallel pharmaceutical and therapeutic and adverse effects of modes of management for premature pharmacological therapy and non- ejaculation especially in Western and lasting effectiveness of therapeutic Central European countries, a (behavioral and technique based) comparison to surgical intervention, methods of management, compared more commonly practiced in Ukraine to surgical intervention – selective and Russia. Where benefit outweighs neurotomy; of branches dorsal risk, adverse effects, sequelae and penile nerves. duration of effectiveness of each Materials and Methods. 162 mode has been compared. patients with premature ejaculation disorder initially self-managed with 283

ISIC-2016 Abstract book pause-squeeze techniques and Results. Of the 25 patients managed pharmacologically with reporting ineffective SSRI dapoxetin (Priligy) 30mg on- pharmacological management, 9 demand 1 hour before sexual reported improvement following intercourse. In case simultaneously dosage adjustment. Total of 88 ED we added phosphodiesterase-5 patients underwent a selective inhibitors 50mg of Sildenefil. Of the neurotomy. Intravaginal Ejaculation 162 patients with premature Latency Time was 1.5 - 3.5 min ejaculation disorder, 72 reported (average IELT was 2 min 37 sec). severe side effects of Follow-up time was 3 months. pharmacological treatment, an Average IELT after surgery was 7 additional 25 reported ineffective min 55 sec. pharmacological management, of Conclusions. Surgical those, 16 still reported intervention (selective neyrotomia) ineffectiveness after dosage is safe, profitable and highly effective adjustment. Those with severe side method treatment of PE and may effects of headache, epistaxis and prove to be a last resort for anxiety with loss of libido or no traditional treatment and in case of therapeutic effectiveness, even after severe side effects and dosage adjustment, underwent a pharmacological ineffectiveness, selective neurotomy by means of instead offering a more permanent selected dorsal penile nerve ligation solution for premature ejaculation. and resection.

Miasoiedov K.V. APPLICATION OF THE HYDRAULIC DESOBLITERATION IN TREATMENT OF PATIENTS WITH CRITICAL LIMB ISCHEMIA Research advisor: Boiko V.V., Professor Kharkiv National Medical University Department of Surgery № 1, Kharkiv, Ukraine

The aim. To estimate the harvested from the amputated lower significance of hydraulic dissection limbs in patients with critical limb of the arterial wall in treatment of ischemia examinated. Hydraulic patients with critical limb ischemia dissection was performed on these as potential method of artery atherosclerotically changed arteries desobliteration. in order to disobliterate its lumen. Materials and methods: there To perform such a method we were 20 parts of the arteries injected isotonic fluid in the 284

ISIC-2016 Abstract book subadvetitial layer to separate arterial lumen from a single obstructing substrate from the arteriotomy orifice as a sole residual artery wall in its lumen. conglomeration. At the same time After atherosclerotic plague the plague was extracted from the separation the last one was extraxted arteriotomy orifice sized 1,5±0,8 cm. from the lumen from the longitudinal In 3 cases we needed to add arteriotomy. In case of incomplete mechanical endarterectomy to our plague separation we added method. mechanical endarterectomy. Conclusions: offered method of Results: we managed to hydraulic endarterectomy allows to complete hydraulic enarterectomy perform a dissection of arterial wall on segments of femoral and popliteal in that way to separate the arteries over 5±2,1 cm, on the tibtial obstructive substrate from the wall arterias this index amounted 3±1,7 and to extract it from the lumen or to cm. In 17 cases we managed to prepare the arterial wall for further separate the plague completely from endarterectomy with Vollmar rings. the wall and extract it from the

N.M. Goncharova MINI-INVASIVE SURGICAL TREATMENT OF COMPLICATED PSEUDOCYST OF PANCREAS SECOND TYPE Kharkіv national medical university MH of Ukraine, department of surgery № 2, Кharkiv, Ukraine

Relevance. Availability variety Materials and methods. The of surgeries, and widespread results of surgery 119 patients with adoption of the practice of minimally complicated PC software second invasive surgery, creates a dilemma type, classification and D'Egidio A. regarding the choice of method of Schein M. (1991). All patients surgical treatment of patients with examination by conventional methods. complicated pseudocyst (PC) of the Results and discussion. In the pancreas. first phase of 119 patients performed The aim - to improve the results mini-invasive technique. Pseudocysts of surgical treatment of complicated puncture under ultrasound control PC software second type were made of 55 patients, classification and D'Egidio A. Schein percutaneous drainage of the PC M. (1991) using a mini-invasive software by type «pigtail» was made techniques. of 17 patients, percutaneous puncture drainage of abdominal 285

ISIC-2016 Abstract book ultrasound – 2, pseudocysts alternative method of X-ray endoscopic ultrasound puncture endovascular intervention allowed performed in 16 patients, endoscopic to keep blood flow through the stenting with cystogastrostomy – 4, vessels, and closed the defect in the endoscopic cystoduodenostomy – 1. vascular wall. Laparoscopic drainage external PC made Conclusions. Patients with the 3 patients, laparoscopic complicated PC software in 81.5% of cystoejunostomy – 5. As of first stage 15 cases of mini-invasive techniques patients with PC software, have been the final step in their complicated by bleeding in their cavity, performed X-ray treatment. In 18.5% of these techniques were used to "expectant" endovascular occlusion vessels, tactics, to facilitate the general which led to bleeding. In 1 patient condition of the patient, followed by with bleeding from major vessels (common hepatic artery) was performance laparotomy established stent-graft as an intervention.

Ievtushenko D., Ievtushenko A.,Vinogradov B., Belousova M. ACUTE CHOLANGITIS IN PATIENTS WITH CHOLELITHIASIS Kharkiv National Medical University Department of general surgery №2, Kharkiv, Ukraine

Actuality. Gallbladder disease The aim. The objective of this is a chronic recurrent hepatobiliary study was to analyze diagnostic disease, the basis for which is the features and surgical outcomes in impaired metabolism of cholesterol, patients with acute cholangitis bilirubin and bile acids, which is caused by choledocholithiasis. characterized by the formation of Materials and methods. 184 gallstones in the hepatic bile duct, patients with obstructive jaundice common bile duct, or gallbladder. was included. Acute cholangitis Cholangitis is an infection of the diagnosed in 62 (33,7%) patients. All biliary tract with the potential to patients underwent surgical cause significant morbidity and treatment. All patients classified mortality. Many patients with acute according TokyoGuidelines 2013(TG cholangitis respond to antibiotic 13). Surgical tactics and dynamics of therapy; however, patients with laboratory data changes analysis severe or toxic cholangitis may not providedat patients with obstructive respond and may require surgical jaundice and cholangitis caused by treatment. choledocholithiasis.

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ISIC-2016 Abstract book Results. TG 13 is simple in use peripheral blood, that correlate with and informative in diagnostic sand haematological indexes, most severity grading of cholangitis. informative among them- index of Acutecholangitis development leads intoxication. to liver malfunction and changes of

Ilyukha Sergey, Mitrofanyk Valeriya, Bogun Marina ALLOPLASTY OF VENTRAL HERNIAS Research advisor: Antonova Marina Kharkiv National Medical University Department of surgery № 2, Kharkiv, Ukraine

Introduction. Nowadays about fistula between skin and transplant, 3-7% of population have ventral granulomas et al. Lichtenstein hernias. And hernioplasty takes 25% hernioplasty was the most from all operations in surgical reasonable method of hernioplasty. hospitals. More than 50000 Conclusion. The basic group hernioplastic surgeries are made in for alloplasty of ventral hernias is Ukraine every year. patients with high risk of relapse of The aim. To investigate hernia (elderly people, high positive and negative aspects of intraabdominal pressure, alloplasty of ventral hernias and to incompetent tissues around hernia define indications for that operation. orifice). It is important to remember Materials and methods. There that small and medium sizes of were 79 patients with hernias. We hernia are indications for have made standard clinical tests for laparoscopic hernioplasty. This type patients and any abnormality was of operation decreases quantity of withdrawal criteria. For all the complications and the term of post- patients alloplasty of hernia was operative period and other. But there made. are some disadvantages such as total Results. In 20.9-49.2% of anesthesia, post-operative patients there was a risk of specific hematomas, tense carboperitoneum, complications from wounds such as expensive operating expendables long exudation, seroma (11.4%), and equipment. The number of hematoma (5.3%), marginal necrosis relapses after laparoscopic operation of skin (1.6%), suppuration (3.5%), is about 0.6-3%.

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ISIC-2016 Abstract book Ivakhnova K. Bogdanets O., Novikova K. CONTENTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR FOR PRIMARY OPEN-ANGLE GLAUCOMA Kharkiv National Medical University Department of ophthalmology Ukraine 2016 Supervisor: prof. Panchenko N.V.

Introduction: Brain-derived Objective: To study the neurotrophic factor (BDNF) is a literature data on serum BDNF, a polypeptide growth factors, essential tear in primary open angle glaucoma. components for the establishment Materials and methods: we and maintenance of neurons. The studied work on serum BDNF, a tear normal plasma level of BDNF with in primary open-angle glaucoma increasing age or weight, as the between 1996 and 2015. platelet level does not Results: According change(Lommatzsch M, et al .; 2005). Ghaffariyeh, et al .; 2011, mean A decrease in serum BDNF in serum levels of BDNF 27.16 ± 5.53 ng Alzheimer's disease and / ml in the control group and 18.42 ± hydrocephalus(Mansour-Robaey S, 4.05 ng / ml in patients with early et al .; 1994), multiple sclerosis stage of glaucoma. In patients with (Laske C, et al .; 2007), chronic glaucoma, which had a lower schizophrenia(Azoulay D, et al .; concentration of BDNF in the serum 2008), Huntington's disease (Ikeda Y, revealed a significant negative et al .; 2008), chronic heroin and correlation with standard deviations cocaine abuse (Ciammola A, et al .; model (Puyan, et al .; 2011). In 2007), bipolar disorder (Angelucci F, determining the BDNF in tears of et al .; 2007), alcohol dependence normal subjects of marked reduction (Kapczinski F, et al ., 2008), affective of his (p <0,001) (Ghaffariyeh A, et al disorders (Joe KH, et al .; 2007), .; 2009). Pease ME, et al .; 2000 eating disorders povedeniyatakie as termination of retrograde transport bulimia and anorexia nervosa of BDNF and TrkB in the (Karege F, et al .; 2002). Individuals accumulation of the optic nerve head who suffered from epilepsy, and in acute and chronic models of long-term treatment with glaucoma assume the role of antidepressants, show an increase of neurotrophins in the pathogenesis of serum BDNF (Nakazato M, et al .; deprivation of RGC death in 2003). glaucoma. The study Schwald M, et al .; 2002, the role of BDNF in the blood platelet and central nervous system,

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ISIC-2016 Abstract book there was a positive correlation up to 50 times lower levels of BDNF between the serum levels and present in citrated human or rat cortical BDNF (r = 0,81, P <0,01), plasma confirms abundant widely particularly in young animals. In rats, distribute this action neurotrophic an increase in IOP slows retrograde factor (Radka SF, et al .; 1996). transport of BDNF colliculus in the Conclusion: The findings retina (Quigley HA, et al .; 2000). indicate pathogenetic role of BDNF in High concentrations of BDNF were primary open angle glaucoma. found in human and rat serum, and

Amritpal Singh Khangura TROPHIC LEG ULCERS Kharkiv National Medical University

(Department of Surgery No. 2)

Actuality. It is ulceration of the a chronic ulcer would be to correctly lower leg caused by peripheral identify the etiology as well as the vascular disease involving either local and systemic factors that could arteries & arterioles or veins & be contributing to its nonhealing venules of the affected limb. nature. According to statistics ulcers Aim. The aim of our study is to complicate the course of chronic identify the results of different venous insufficiency (CVI) in 15-18% methods of treating venous ulcers. of cases and occurs in 1-2% of the Materials and methods. In working population; with age, their Kharkiv regional hospital were frequency increases to 4-5% in treated 26 patients with chronic patients older than 65 years, and the venous insufficiency 6th grade radical elimination of the disease can (CEAP). We did 18 (69%) venectomy only be achieved in every tenth as method of decrease of venous patient (I.A. Zolotukhin, 2007). In stasis. 19 (73%) ulcers healed by addition, even in the event of the conservative care, and 7 (27%) closure of venous ulcers is high patients undergone skin grafts by frequency of recurrence: after Tires. All patients were receiving surgery, according to different medicamental treatment according authors, from 4.8 to 31.6%, as a to the guidelines. After 1 year of result of conservative methods - supervision we have got recurrency from 15 to 100%. of venous ulcers in 5 (19%) patents, The key to successful management of which were not operated.

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ISIC-2016 Abstract book Conclusion: The management may be different in each case. If the of patients with trophic ulcers and patient understands that changing their consequences is difficult not habits and making a few lifestyle only because it is a recurrent and changes could help in preventing the recalcitrant problem but also progression of disease, the prognosis because the pathogenesis of the ulcer are good.

Khodak A.S. THE CASE OF PRIMARY – PLURAL MALIGNANT TUMORS OF FOUR LOCALIZATION Kharkov National Medical University Department of oncology, Kharkiv, Ukraine

Actuality. The frequency of Peity, a course of distant gamma primary multiple cancer (PMC) or therapy and chemotherapy were polyneoplasia in humans ranges made. from 3.4% to 11%. According to Results. Melanoma in the various authors heredity, age, sex, retina of the right eye was diagnosed addictions and therapy, carried out in 2011. Enucleation of the right eye at the first tumor (radiation and was made. A made third tumor - chemotherapy) are considered to be renal - cell carcinoma of the right the most frequent causes of PMC. kidney in the same 2011 was Most often develop 2 tumors, rarer 3, diagnosed right nephrectomy. and 4-7 tumors are very rare. Cancer of the left breast. T3N1M0 Depending on the time of PMC was in 2013 diagnosed. A 3-course appearance they can be synchronous neoadjuvant chemotherapy, radical (that develop simultaneously) and mastectomy of the left breast, and metachronous that develop in the postoperative course of succession with a time interval. gammaterapy 3 courses of adjuvant Materials and methods. We chemotherapy were made. The conduct surveillance of patient was observed by the local metachronous PMC having our oncologist. In 2016 established The locations. 47 year old patients ch. generalization of the process in the consulted with the physician for the form of metastases in the lungs, liver first time regarding tumor in the and left adrenal gland was in 2016 right breast in 2004. established chemotherapy was In the study cancer of the right started carrying out. The longest breast T2N1M0 was diagnosed with. interval was observed between the 1 Radical mastectomy, according to st and 2 nd tumor and it lasted for 7 290

ISIC-2016 Abstract book years. The period between the first a group of patients with increased and the 4 tumor was 9 years. risk of recurrent malignancies. Conclusions. Study of PMC is current because it allows to identify

Khvorostinko Ruslan THE OPTIMIZATION OF TREATMENT OF THE RETINOPATHY OF PREMATURITY Research advisor: Ilyina Yevgeniya Kharkiv National Medical University Department of Ophthalmology, Kharkiv, Ukraine

Introduction. The retinopathy 579 medical histories of infants with of prematurity (ROP) is serious gestational age more than 29 weeks disease of the retina due to its and birth weight more than 700 unfinished development, which leads grams for the period 2013 - 2016. to vascular proliferation and retinal Results. Following results are detachment. Currently, humanity has obtained: treatment for ROP depends the ability to birth prematurely-born on the stage of the condition. Stage 1 babies (gestational weeks 28-40), and 2 usually require nothing more weighing from 700 grams. However, than observation. the full development of the retina The treatment of stage 3 disease occurs to 40 weeks of gestational involves laser or cryotherapy to burn age. Therefore, actual task for the avascular retina. Laser therapy ophthalmologists is to reduce (transpupillary diode laser therapy) disability due to this disease and to is first-line treatment. If this is prevent pathological changes of unavailable, cryotherapy or argon posterior segment of the retina. laser treatment may be used. The aim. the optimization of Cryotherapy requires conjunctival treatment of ROP by developing an incisions. Intravitreal VEGF algorithm of activities, depending on injections show some promise for the stage of the disease. zone I but not zone II disease. Materials and methods. A Steroid, antibiotic and mydriatic eye retrospective analysis of medical drops are used afterwards. records of the perinatal center and For stage 4-5 disease: vitreoretinal children's ophthalmology surgery is required to re-attach the department of Kharkiv Regional retina. Lens-sparing vitrectomy for Clinical Hospital, Center of early degrees of retinal detachment Emergency Medical Care and results in good outcomes for lens Disaster Medicine. We have studied clarity and vision in the majority of 291

ISIC-2016 Abstract book babies with ROP. haemorrhage (OR = 2,4), sepsis (OR = 2,2), and apnea (OR = 1,5). Babies with only stage 1-2 ROP need Meanwhile, phototherapy was only have the routine national vision significantly protective against ROP screening, unless there is specific development, with an OR of 0.6. concern. Сonclusions. Thus, according to All babies with stage 3 ROP or more the above data it's necessary to in which ROP resolved select a treatment regimen, spontaneously, and babies requiring depending on the stage of the treatment of ROP, require disease. It is possible to prevent ophthalmic review at least until 5 undesirable consequences and years of age. complications during the early stages The risk factors of ROP progression of the disease because of timely are oxygen therapy (odds ratio [OR] diagnosis and the use of new = 3,7), comorbidities: respiratory methods of treatment (like laser or distress (OR = 2,2), intraventricular cryotherapy; VEGF injections).

Kruglyak V. TREATMENT OPTIMIZATION OF DELAY EJACULATION Research advisor: Knigavko A., МD, PhD, Professor Kharkiv National Medical University Department of Urology, Nephrology and Andrology, Kharkiv, Ukraine

Actuality. Every man during V.I.Shapoval” 82 DE patients with all his life faces with sexual problems. equal indexes were examined and Ejaculatory problems are the most treated. 40 patients’ DE (group 1) is susceptible and delicate ones. A lot of caused by organic reasons (diabetic scientific works are dedicated to neuropathy, prostate infections, premature ejaculation, at the same alcoholism, transurethral resection time delay ejaculation is not of the prostate) and 42 patients’ DE completely explored. (group 2) by nonorganic reasons The aim. Is to determine the (psychogenic disorders, depression, optimal treatment method experienced stress, "male" depending on MIEF, HDRS with complexes). Patients were gathered: psychopathology and sexual sexual history, intravaginal latency intercourse satisfaction based on time (IVLT) duration, questionnaire different treatment regimens in as MIEF and Hamilton scale for delay ejaculation patients (DE). assessing depression (HDRS), Materials and methods. In ultrasound of the genitourinary the HCPI “KhRCCUN named by system. 292

ISIC-2016 Abstract book Results. In group of organic the best results are in groups 1b reasons of DE mainly all MIEF points (22,1 ± 2,0) and 2а (14,4±2,3). The were worse ( 17,6±3,1 points ). In analysis of patient groups shows a subgroup 1a patients were taking decline of neurotic manifestations in Keltican with vit.B6. In the subgroup nonorganic DE patients due to taking 1b to the medications above tropho- in agonist5-НТ1А ( Buspirone ) and stimulating therapy of neuro-reflex ІЗЗС (Sertraline). centers of the spinal cord was Conclusions. The biggest prescribed. Group 2a was taking effect that is reflected in improving Buspirone. Group number 2b – indicators of MIEF index, sexual Sertraline. In group 1a taking in of intercourse satisfaction and general Keltican with vit.B6 has improved satisfaction is in group 1b ( 22,1 ± MIEF up to 20,5 ± 1,7, however 2,0 starting from 17,6±3,1 points ) tropho-stimulating methods adding thanks to combined treatment: to this treatment has shown us keltican, vit.B6 and physiotherapy. In bigger effect to 22,1 ± 2,0. In group of the second group buspirone ( Buspirone (14,4±2,3) results are 14,4±2,3 from 9,3±1,8 ) is more higher than in sertraline group effective than sertraline (12,8±1,5 (12,8±1,5) from the beginning from 9,3±1,8 ) in treating 9,3±1,8 for both. According to the nonorganic DE. Finally to sum up, the results of the sexual intercourse therapy provides improvement of satisfaction all groups have the results in men with delay improvements due to treatment – ejaculation.

Kruglyak V. TREATMENT OPTIMIZATION OF DELAY EJACULATION Research advisor: Knigavko A., МD, PhD, Professor Kharkiv National Medical University Department of Urology, Nephrology and Andrology, Kharkiv, Ukraine

Actuality. Every man during depending on MIEF, HDRS with his life faces with sexual problems. psychopathology and sexual Ejaculatory problems are the most intercourse satisfaction based on susceptible and delicate ones. A lot of different treatment regimens in scientific works are dedicated to delay ejaculation patients (DE). premature ejaculation, at the same Materials and methods. In time delay ejaculation is not the HCPI “KhRCCUN named by completely explored. V.I.Shapoval” 82 DE patients with all The aim. Is to determine the equal indexes were examined and optimal treatment method treated. 40 patients’ DE (group 1) is 293

ISIC-2016 Abstract book caused by organic reasons (diabetic Buspirone (14,4±2,3) results are neuropathy, prostate infections, higher than in sertraline group alcoholism, transurethral resection (12,8±1,5) from the beginning of the prostate) and 42 patients’ DE 9,3±1,8 for both. According to the (group 2) by nonorganic reasons results of the sexual intercourse (psychogenic disorders, depression, satisfaction all groups have experienced stress, "male" improvements due to treatment – complexes). Patients were gathered: the best results are in groups 1b sexual history, intravaginal latency (22,1 ± 2,0) and 2а (14,4±2,3). The time (IVLT) duration, questionnaire analysis of patient groups shows a as MIEF and Hamilton scale for decline of neurotic manifestations in assessing depression (HDRS), nonorganic DE patients due to taking ultrasound of the genitourinary in agonist5-НТ1А ( Buspirone ) and system. ІЗЗС (Sertraline). Results. In group of organic Conclusions. The biggest reasons of DE mainly all MIEF points effect that is reflected in improving were worse ( 17,6±3,1 points ). In indicators of MIEF index, sexual subgroup 1a patients were taking intercourse satisfaction and general Keltican with vit.B6. In the subgroup satisfaction is in group 1b ( 22,1 ± 1b to the medications above tropho- 2,0 starting from 17,6±3,1 points ) stimulating therapy of neuro-reflex thanks to combined treatment: centers of the spinal cord was keltican, vit.B6 and physiotherapy. In prescribed. Group 2a was taking the second group buspirone ( Buspirone. Group number 2b – 14,4±2,3 from 9,3±1,8 ) is more Sertraline. In group 1a taking in of effective than sertraline (12,8±1,5 Keltican with vit.B6 has improved from 9,3±1,8 ) in treating MIEF up to 20,5 ± 1,7, however nonorganic DE. Finally to sum up, the tropho-stimulating methods adding therapy provides improvement of to this treatment has shown us the results in men with delay bigger effect to 22,1 ± 2,0. In group of ejaculation.

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ISIC-2016 Abstract book Nahorna D., Yakovenko V. ENDOSCOPY DISSECTION OF SMALL STROMAL TUMORS OF THE UPPER GASTROINTESTINAL TRACT Research advisor: Kuryk O., MD PH Bogomolets National Medical University Miniinvasive surgery (pathomorphological), Kiev, Ukraine

Actuality. Gastrointestinal vimentin to identify the stromal tumors (GIST) are rare characteristics of the tumors. neoplasms arising from connective Results. The study group tissue elements of the consisted of 4 men and 6 women gastrointestinal wall. They show a aged 34-65 years. Two tumors were great heterogeneity with respect to located in the esophagus, 3 in the their histogenetic, morphologic and gastric corpus, 2 in the gastric prognostic characteristics. fundus, 3 lesions in the gastric The aim. To analyze the cases antrum. All tumors were rermoved of endoscopy dissection of small by endoscopic submucosal stromal tumors of the upper dissection (ESD). The average gastrointestinal tract. maximum diameter of tumor was Matherials and methods. A 10.6 ± 4.8 mm, with a range of 6 to total of 10 patients with esophageal 20 mm, and another lesion was and gastric submucosal tumors ligated by an endoscopic ligator after emerged from the muscular layer most of the lesion was dissected. identified by endoscopic After pathological and ultrasonography were collected from immunohistochemical analysis, 8 2010 to 2015. Extramural or tumors were identified as a dumbbell-like lesions were excluded gastrointestinal stromal tumor and 2 by an enhanced computerized were leiomyoma. Perforation tomography scan. All patients had occurred in 1 patient and intravenous anesthesia with conservative treatment succeeded by propofol and then underwent the a suturing clip and no post-operative ESD procedure to resect these bleeding occurred. submucosal tumors.. All the Conclusions. ESD is a safe and specimens were evaluated by feasible technique to resect immunohistochemical staining, with esophageal and gastric submucosal antibodies against CD117, CD34, tumors and the incidence of desmin, α-smooth muscle actin and complications was very low.

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ISIC-2016 Abstract book Olaniyan M.M., Kasiev S. IMPROVEMENT OF THE SEXUAL FUNCTION OF PATIENTS WITH VENO- OCCLUSIVE ERECTILE DYSFUNCTION AND BILATERAL VARICOCELE Research Advisor: Knigavko A., PhD Kharkiv National Medical University Department of Urology, Nephrology and Andrology, Kharkiv, Ukraine

Actuality. ED is more likely to abnormal flow of blood, it can be occur in men, young or middle age. assumed that there’s an innate The link between varicocele and predisposition to ectopic veins and erectile dysfunction is proved in a insufficiency of genitalia in patients study by Keller JJ, Chen YK, Lin HC.In with varicocele and comorbid ED. the course of clinical observations of When patients have distal venous patients with varicocele in leakage through deep dorsal veins conjunction with erectile dysfunction and Santorini plexus, sclerotherapy in the Kharkiv Regional Clinical of deep veins by R.Hervig shows Center of Urology and good results. Unfortunely there are Nephrology(KRCCUN), Shapoval, no officially registered sclerosants in significant reduction of testosterone Ukraine. That is why to stop was not revealed. Australian School pathological bloodflow, we use of Advanced Medicine, Sydney, embolization with metallic spirals. Australia and Department of But if the patients have proximal Urology, National Taiwan University venous leak we suggest better Hospital, Taipei, Taiwan concluded effectiveness of treatment by ligation that ‘venous’ aetiology should be an of the pathological shunts. important factor in young males who Materials and Methods. On suffer from erectile dysfunction (who the basis of the KRCCUN, practice the Jelqing maneuver) in comprehensive examination and their thesis. treatment of 65 patients suffering For ED caused by abnormal from ED, veno-occlusive form and venous discharge, significant outflow bilateral varicocele was conducted. of venous blood in pathological shunt The average patient age was 37.5 takes place (via the great saphenous +4.4 years. This form of ED is vein, dorsal or enlarged cavernous diagnosed by medical history and by veins), which makes it impossible to Doppler mode ultrasound of the maintain an erection at the proper scrotum and penis. The patients level (to achieve orgasm). Given that underwent surgical treatment: the varicocele is also a manifestation bilateral operation of “Marmar” with of pathology of veins due to ligation of the veins (pathological

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ISIC-2016 Abstract book shunts) coming from the penis to the problems is a marker and one of the spermatic cord and vena superficial reasons of veno-occlusive form of penis. Before the operation, we ED. 2) Modified (with ligation of the injected 10 mg of alprostadil and 1 dorsal and communicating veins) ml of papaverine into the penis for duplex operation of Marmara is a enlargement and better searching of highly effective (85-94%) method of the pathological shunts. treatment for patients with proximal Results. The efficacy of venous leak. 3) Angiosurgery with surgical treatment of the subjective embolisation of the deep pelvic vein (questionnaires on IIEF) - 83.7%, the is a satisfactory method (67%) for objective –in the absence of venous treatment of ED in patients with shunt on Doppler US -94%. distal venous leak. Conclusions. 1) Bilateral varicocele in young men with erectile

Olefir O., Zamyatin D. HEART AND PERICARDIUM DIAGNOSTIC FEATURES DURING MINE-BLAST TRAUMA Mentor: Zamyatin P. Department of surgery #1 Kharkiv National Medical University

Mine-blast trauma of heart is examination of the patients considered to be the most common cardiovascular system: - palpation - type of fatal injuries during percussion - auscultation 2. peacetime and wartime. The Instrumental methods: - experience of treating this kind of electrocardiography 3. Laboratory trauma is negligible, even in the methods: - determining CK and it`s world`s leading hospitals. MB-fraction level - determining Aim: The aim was to evaluate troponin I level the informativeness of symptoms Results: 1. According to the obtained by objective examination, information content of the clinic as well as the data of instrumental clinical symptoms: - and laboratory studies in patients Pain in the heart - in 25.65% - with mine-blast injury of the heart. Voiceless heart tones - at 100.0% - Material and Methods: There Systolic murmur at the apex - to were 74 patients with mine-blast 9.45% - trauma, to perform our tasks we Pericardial rub - 5.4% - used such methods as 1. Physical 297

ISIC-2016 Abstract book Tachycardia - 120 bpm. 1 min. - in 68.9% of cases. Conclusion: 3. - 16.2% - Increased level of CK in patients with Decrease in systolic blood pressure heart contusion was observed in <60 mm Hg. Art. - In 37,8-47,25% - 100% cases - Increased level of MB- Decrease in pulse pressure <15 mm fraction was observed in 96.7% - Hg. Art. - In 32,4-44,55% 2. Ratio of MB-CK and total CK higher ECG in patients with cardiac injury – than 5% occurred in 26.7% of cases Changes in the T wave detected in 4. The troponin I level in patients 75, 7% of cases, - P wave - 35.1%, the with heart contusion was increased segment S-T - 35,1%, - Arrhythmia - in 100% of cases.

Onuchukwu Chibuzor Victor, Gavura M. EFFICACY AND SAFETY OF SURGICAL TREATMENT OF THE VITREOMACULAR TRACTIONAL SYNDROME Research advisor: Zubkova D. Kharkiv National Medical Iniversity Department of ophthalmology, Kharkiv, Ukraine

Actuality. Background Materials and Methods. Vitreomacular tractional (VMT) Under supervision there were 17 syndrome is a disorder of the vitreo- patients with VMT syndrome. retinal interface characterized by an Research methods were best- incomplete posterior vitreous corrected Snellen visual acuity, static detachment, an abnormal strong perimetry, Amsler grid and optical adherence of the posterior hyaloid coherence tomography before and membrane to the macular and after the operation. The follow-up anteroposterior traction leading to period was 3 years. formation of macular hole. This Results. The pars plana pathology is becoming a menace in vitrectomy with inner limiting the society due to its prevalence membrane peeling caused reported to be 22.5 per 100,000 disappearance of retinal traction that population annually and high results in a gradual decrease of incidence rate in Ukraine and in macular edema according to a data of Europe and is becoming more among optical coherence tomography as the aging population. well as improvement of distant The aim. Was to analyze prognosis. After 3 years, visual acuity efficacy and safety of the pars plana increased from 0.42± 0.05 to 0.61± vitrectomy with inner limiting 0.04 (p =0.01), scotoma frequency membrane peeling among patients decreased from 100 % eyes to 57.1 with VMT syndrome. % (p =0.04), and metamorphopsia 298

ISIC-2016 Abstract book frequency decreased from 100 % inner limiting membrane peeling is eyes to 79.2 % (p=0.04). effective and safe in complex Conclusion. This study show treatment of VMT syndrome. that pars plana vitrectomy with

Pazhin S.O., Ponomareva K.V., Minuhin D.V., Lozhko N.V. ROENTGEN-ENDOVASCULAR METHODS OF HEMOSTASIS IN PATIENTS WITH PULMONARY HAEMORRHAGE Research advisor: Boyko V.V., Professor Kharkiv National Medical University Department of Surgery No. 1, Kharkiv, Ukraine

Actuality. Pulmonary Roentgen-endovascular intervention haemorrhage (PH) as a complication was performed for 119 patients in can be found in 7-14% patients with clinic of State institution called different diseases of lungs that reach “Institute of General and Emergency thoracic region. Surgery named after V.G. Zaytsev of A great number of control means for National Academy of Medical this pathology, the part of which is Sciences of Ukraine”. Among them 39 based on wrong belief about patients had acute and chronic pathogenesis of PH, typically inflammatory lung diseases and 80 complicates the choice of optimal patients had malignant diseases treatment tactics, and leads to complicated with PH. ungrounded extension of indications Bronchial and intercostal arteries for major surgical interventions that angiography makes it possible to is detrimental to short-term results define the source of haemorrhage and unsatisfactory rehabilitation of and the following roentgen- patients in remote period. endovascular embolization of Endovascular embolization of bleeder allows temporary or final bronchial arteries makes it possible controlling of PH. to accomplish final hemostasis in 90- Catheterization of bronchial arteries 95% cases and this is one of the main was performed according to treatment methods of this severe standard methods. Synthetic emboli complication in patients with treated with sclerosing agents from malignant tumors. poly-urethane foam or hemostatic The aim. Efficiency sponge of 1-3 mm in diameter were improvement of treatment of used as embolic agent. Bronchial patients with PH of different etiology arteries occlusion was stopped if using endovascular surgery methods. contrast agent reflux occurred in Material and methods. thoracic aorta and clear symptom 299

ISIC-2016 Abstract book called “blood flow retention” 10 (8.4%) patients and conservative appeared in bronchial arteries. therapy used for 2 (1.7%) patients Results. It was found that out was without effect. of 119 patients after endovascular Conclusions. Therefore occlusion of bronchial arteries the angiography of bronchial arteries is final hemostasis was achieved in 107 highly effective in defining (89%) patients. Relapse of localization and source of PH and haemorrhage in remote periods after solving the problem of hemostasis in roentgen-endovascular embolization oncologic or obstruction lung occurred in 12 (10%) inoperable diseases. Endovascular intervention patients with malignant diseases of provides effective (89%) hemostasis lungs. Repeated roentgen- in PH and allows reducing mortality endovascular embolization with from 10.2% to 1.7%. positive results was performed for

Petiunin Pavlo; Petiunina Victoriya; Petiunin Olexij A NEW NONINVASIVE TECHNIQUE FOR EVALUATION OF ACUTE-ON- CHRONIC LIVER FAILURE IN THE CIRRHOTIC PATIENTS. Research advisor: Byzov Denys, Assoc. Prof. Kharkiv National Medical University Department of General surgery №2, Kharkiv, Ukraine

Actually. “Acute-on-chronic Materials and methods. liver failure” (ACLF) is a most We included 137 patients with liver common postoperative complication cirrhosis, at whom surgical in the cirrhotic patients, which treatment was performed. In results in a patients death in 33,9% - 81(59,12%) cases was performed 53%. That’s why the early diagnosis, the distal splenorenal shunt by prevention and treatment of ACLF is Warren, in 56 (40,88%)– one of the important problems of devascularization surgery. Doppler modern hepatobiliary surgery. ultrasound of portal blood vessels The aim. Of this study is was done at admission by Moriyasu to work of new noninvasive et al. method. The statistical analysis technique of functional liver reserve was performed by use of “Microsoft evaluation in cirrhotic patients, Excel 2000” and “SPSS 10.0 for based on use of Doppler ultrasound, Windows”. in order to prevent and diagnose Results. Patients with ASLF postoperatively. postoperative ACLF had portal vein diameter to be enlarged up to 1,5 300

ISIC-2016 Abstract book 0,026 (P<0,001), splenic vein changes. Liver cirrhotic patients with diameter also becomes to be enlarge developed postoperative ACLF had up to 1,32 0,035 cm (P<0,001) in linear portal blood velocity 1,6 times comparison with patients without less both portal congestion index 2,8 ACLF. Patients with postoperative times more than patients without ACLF had linear portal blood velocity this complication.ACLF developed in to be decreased to 10,8 ± 0,48 patients, who had portal vein cm/sec (P<0,02) with diameter more than 1,5 cm, linear simultaneously increased portal portal blood velocity less than 10,8 congestion index up to 10,8 ± 0,48 cm/sec, portal congestion index cm х sec (P<0,001) in comparison more than 0,14 cm х sec.Conclusion. with patients without ACLF. Doppler ultrasound, used for Volumic portal blood velocity evaluation of a portal at development of ACLF decreases to hemodynamics, is a modern 997,57 72,11 ml/min, but noninvasive effective technique in differences are statistically diagnosis of acute-on-chronic liver insignificant. These changes of potal failure. hemodynamics can be explained by Conclusion. ACLF more expressed increase in development is accompanied by connective tissue mass in hepatic increase in diameters of portal and parenchyma at patients with spleenic veins, decrease in linear developed ACLF. portal blood velocity, volumic portal Analysis of portal Doppler blood velocity, increase in potal ultrasound results revealed that congestion index. linear portal blood velocity together Linear portal blood velocity with portal congestion index are and portal congestion index most most significant indexes, reflecting exactly reflexes the character of character of pathological liver pathological changes in liver.

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ISIC-2016 Abstract book Petrychenko I.I. DILATED PUNCTURE TRACHEOTOMY Research Advisor: Kalashnik J., Assistant Kharkiv National Medical University Departnment of Otorhinolaryngology, Kharkiv, Ukraine

Actuality. Over the last years is inserted into the endotracheal the priority is being given to the tube and its end is installed at the dilated puncture tracheotomy distal opening level of the tube. The method. This technique is widely syringe is filled with low- used in the world practice. concentrated local anesthetic (for This kind of tracheotomy has better hydropreparation of tissues), to be executed by a team of doctors a needle hub is put on, the skin is consisting of a resuscitator- punctured at right angle to the skin anesthesiologist, anesthesiology in the spot of the bronchoscope nurse, endoscopist. The surgery visualization and the needle moved must take place in the intensive inwards injecting the anesthetic and therapy unit. The primary ground for intermittently pulling the plunger. percutaneous tracheotomy is the Having got air from the aspiration, necessity of prolonged ALV to the needle is moved another 2-3 mm, prevent ventilator associated the hub is moved down the needle pneumonia and pressure injuries of and into the trachea. A metal flexible mouth corners. The surgery is conductor is entered through the conducted under general hub. Skin incision with a lancet is intravenous anesthesia. carried out where the stoma is Neuromuscular blockers are also supposed to be, left a right of the absolutely necessary in order to conductor. The size of incision avoid coughing during the trachea should correspond to the size of the puncture, which, in its turn, installed tube. Further actions significantly reduces the risk of depend on the chosen method. injuring the trachea back. The main The most frequently used methods include: one-step dilatation method is the Griggs method, due to (Smiths-Portex), subsequent its numerous advantages. When this dilatation (Rusch), Grigg’s method method is used, the stoma is shaped (Smiths-Portex), «twisting in» by means of Howard-Kelly clasp, method (Rusch). The first stage of which has an internal channel for the the surgery is the same for all conductor. The primary dilatation is methods. It includes regulation of the carried out with a small-diameter endotracheal tube and installation of dilator. Then the opening in the a conductor according to the trachea is done by clasp. The tube Seldinger method. The bronchoscope with an integrated obturator is put

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ISIC-2016 Abstract book on the conductor and injected into Conclusions. Unlike the the trachea. Then the tube cuff is traditional way, this method is less inflated and the obturator is traumatic, the risk of bleeding during removed together with the the execution is reduced, and the conductor. The breathing circuit is surgery takes less time compared to switched to the tracheotomy tube, the open method. At a later stage it endostomic tube is removed reduces the risk of the surgery lowering the cuff. wound infection and the size of the surgical scar.

Prykhodko D.О., Arustamova G.S., Khatsenko I.O. CLINICAL FEATURES OF EXPERIMENTAL MODELS OF OCULAR HYPERTENSION AND GLAUCOMA Kharkiv National Medical University (Ophthalmology department), Kharkiv, Ukraine Scientific leader – professor Panchenko M.V.

Topicality: The research of There are models of glaucoma with glaucoma always causes the great using of administering substances in interest for doctors and scientists. the anterior chamber - viskoelastik- Glaucoma is the leading matter of (L. Tongren et al, 2000) and blindness and visual impairment microspheres - (J.H. Urcola et al, worldwide. Currently there are some 2006). There are complications as available models in which glaucoma inflammation of the anterior is caused by corticosteroids (L. segment of the eye, which makes Bonomi et al., 1978). However, this difficult visualization of the clinical model has a range of complications picture. These models are such as the formation of purulent accompanied by rapid and sharp corneal ulcers and steroid cataract increase of IOP and used as models development. It is a model of of ophthalmohypertension. Also the primary and hormone glaucoma. outflow of intraocular fluid can be There is also a model of glaucoma blocked by coagulation of episcleral induced by injections of hypertonic veins (S.R. Shareef et al. 1995). In the saline into episcleral veins (J.C. experimental result there is an Morrison et al., 1995). The advantage increase of IOP due to an acute is a gradual increase of intraocular process, while a human glaucoma is a pressure (IOP), but it can be chronic pathological condition. associated with inflammatory Objective: To create a model of complications, corneal opacity, glaucoma in rabbits as close as it is vascular ingrowths, which possible to human disease and to complicates the fundus examination. evaluate the dynamics of the IOP. 303

ISIC-2016 Abstract book Materials and methods: Model of caused a gradual increase in rabbits' glaucoma was established in old IOP with the subsequent rabbits (n=10), bred chinchilla and development of excavation of the white giant by the injections optic nerve. of adrenaline into the ear vein (E.M. Conclusion: The experimental Lipovetskaya, 1966) by proposed glaucoma, caused by the injections of method of I.N.Miheytseva (2011). adrenaline in rabbits, corresponds to There was a control of IOP before the the clinical picture of the primary injections of adrenaline and after open-angle glaucoma in human. It development of glaucoma using can be used as a model for studying Maklakov tonometer (weight 7.5 g) of the drugs’ effects in the treatment under the local anesthesia. of glaucoma. Results: The injections of adrenaline

Riznychenko A.N. ANALYSIS OF FEATURES GUNSHOT BONES WOUNDS Research Advisor: Istomin D.A., Assistant Kharkiv National Medical University Department of Traumatology and Orthopaedics Kharkiv, Ukraine

Actuality. Character of it’s necessary to know most frequent wounds taking in time of hostilities features of gunshot bones wounds has change, when the firearms and take to consideration experience emergence. Firearms of old time of wars from WWII to modern time. fractures were perforated and Materials and methods. diameter of wound channel matched Outlet have biggest dimensions, if diameter of bullet nearly 15-17 mm. bullet have shifted center of gravity Because of low start bullet speed outlet can to be near inlet and crack outlet did not have and wounds were manifest between them. Seriousness closed. In modern conditions 35- of spinal wound depends on damage 40% of gunshot wounds or contusion of spinal cord, save of accompanied bone fractures. This is bone structures and nearly organs. very important fact because in 65% Even if bullet directly not damage of gunshot wound bones spinal cord, contusion of spinal cord accompanied with shell-shock, is occur. The most common 96,7% - with massive blood loss, complication of spinal cord wounds 31% - secondary bacterial infection. is peripheral paralysis. Moreover, The aim. In conditions of other complication are shell-shock, situation in the East part of Ukraine, blood loss, festering of wound, 304

ISIC-2016 Abstract book sepsis, pneumonias, arachnoiditis, ray survey held wound excision and scarring of spinal cord. Treatment is determined seriousness of bone replacement of destroyed vertebrae wound. Lost contact with periosteum implants, fixation of broken fragments and contaminated processes with intraosseous extremities of bones are deleted ostheosynthesis. Outlet have biggest from wound. Remaining bone dimensions, if bullet have shifted fragment are fixated with center of gravity outlet can to be extramedullary ostheosynthesis. near inlet and crack manifest After wound healing, especially between manifest them. wound of shin, use methodic of Wounds of human limbs divide extrafocal ostheosynthesis. Use depending on marginal and fully: spoke devises, core devises are transverse, longitudinal, oblique, commonly use in case of femur comminuted and crushed. Most wounds. frequently this wounds are primary Conclusion. Because of high open and primary bacterial infected. level of military techniques and High kinetic energy of bullet causes increase of start bullet speed number destroy of bone tissue with form a lot of though wounds are increase, of fragments and damage closed gunshot bones wounds become more placed nervous and blood vessels. In destructive. So further study and case of wound limb must be fixed in design of new bone wounds Krame bus or cast to avoid the treatment methodic and package of occurrence of shell-shock. In next complication prophylactic are stages of medical evacuation after X- necessary.

Robak Vsevolod, Kurbatov Vadym, Drana Lydmyla THE CHOICE OF OPERATIVE ACCESS IN PATIENTS WITH ACUTE NECROTIC PANCREATITIS Research advisor: Syplyvyi Vasyl, Professor Kharkiv National Medical University Department of General Surgery №2 Kharkiv, Ukraine

Actuality: as you know, the between the operativel access and choice of operative asses should the regeneration rate of the major provide not only conducting of body systems in patients with acute adequate operative method, but also necrotic pancreatitis. ensure quick postoperative Materials and methods: There rehabilitation of patient. is an analysis of surgical treatment of The aim: to find the correlation 100 patients with acute necrotic 305

ISIC-2016 Abstract book pancreatitis. All patients operated. (р<0,05). 72 hours after operation Laparoscopic sanation and degree of severity of patients intraabdominal drainage performed undergoing laparoscopy was in 35 patients. Medial laparotomy (9,1±1,97) points, undergoing performed in 50 patients. Subcostal subcostal laparatomy – (11,3±1,52) asses performed in 15 patients. points, undergoing medial Conversion after laparoscopic laparotomy – (12,2±1,76) points diagnostics performed in 10 patients. (р<0,05). From them subcostal asses Conclusions: performed in 7 paients, medial 1. The course of acute necrotizing laparotomy – in 3 patients. For pancreatitis accompanied with determining the recovery rate in multiorgane failure. early postoperative period we used 2. There is a direct correlation Acute Sepsis Severity Evaluation between the operative asses and Scale – ASSES (Syplyviy V., 2005). recovery rate in early postoperative Results: The degree of severity period in patients with acute of patients before operation was necrotic pancreatitis. (15,05±1,04) points. 24 hours after 3. The least traumatic access to operation degree of severity of operations in acute necrotic patients undergoing laparoscopy pancreatitis ensuring rapid recovery was (11,5±1,37) points, undergoing of the major body systems is the subcostal laparatomy – (13,44±2,01) laparoscopic. If the conversion is points, undergoing medial necessary, the preference should be laparotomy – (15,1±1,02) points for subcostal access as possible.

Salawu K.T. ROLE OF DIFFERENT PARTS OF THE DUODENUM IN THE SEVERITY OF DUODENAL TRAUMA Research advisor: Teslenko S.N., Professor Kharkiv National Medical University Department of surgery, Kharkiv, Ukraine

Actuality.The occurrence of 3rd(inferior part), and the duodenal trauma is rare due to the 4th(ascending part). deep location of the duodenum, its The aim. Of the research.To relatively small size, and protection determine the connection between from surrounding organs. The the affected parts of the duodenum duodenum is divided into the and the severity of duodenal trauma. 1st(superior part), the Materials and methods. The 2nd(descending part), the study involved 20 patients. The 306

ISIC-2016 Abstract book patients were divided into 4 groups: and peritonitis. While, patients in 5 patients with trauma of the 1st groups D3 and D4 had mild part of the duodenum (D1) had symptoms of colitis, and a slight risk injuries of the pancreas, gallbladder of superior mesenteric artery and bile duct, 5 patients with trauma syndrome. Patients in groups D1 and of the 2nd part of the duodenum D2 fell into grades 4 and 5 of the (D2) had injuries of the pancreatic duodenal trauma scale while those in duct and common bile duct, 5 groups D3 and D4 fell into grade 1 of patients with trauma of the 3rd part the trauma scale. of the duodenum (D3) had injuries of Conclusions. Patients in the superior mesenteric artery, and groups D1 and D2 were in grave the remaining 5 patients with conditions and had a higher risk for trauma to the 4th part of the mortality. Only 5% of patients in duodenum (D4) had no groups D3 and D4 with superior accompanying injuries. mesenteric artery syndrome were at Results. The severity of the high mortality risks. We have come duodenal trauma was assessed to a conclusion that patients with according to the duodenal trauma affection of more vital organs like scale by the AMERICAN pancreas, gallbladder, and bile duct ASSOCIATION FOR THE SURGERY OF had the most severe forms of TRAUMA. Patients in groups D1 and duodenal trauma while those with D2 had the most severe symptoms. less affection of surrounding organs Their symptoms included had milder forms of duodenal pancreatitis, cholecystitis, trauma. cholangitis, duodenal diverticulum,

Ivzhenko L., Sheremeta I. THE NATURE OF CHANGES IN MEIBOMIAN GLANDS IN PATIENTS WITH DIABETIC POLYNEUROPATHY Kharkov National Medical University (Ophtalmology Department, Kharkov, Ukraine)

Actuality: Diabetic neuropathy is according to different authors, varies interpreted as dysfunction of the from 40 to 95% of all cases of somatic and/or autonomic diabetes. Disorders of innervation of peripheral nervous system, caused the meibomian gland in DPNP leads diabetic and dysmetabolic to changes in the composition and pathophysiological processes. The stability of the tear film, which is frequency of diabetic neuropathy, manifested by blurred vision, 307

ISIC-2016 Abstract book dryness and burning of the eyes, in Results: All indicators of meibomian some cases, their redness. glands secretion among patients Objective: to examine the nature of with diabetic polyneuropathy were changes in the condition of decreased in comparing with the meibomian glands in patients with control group. The result of diabetic polyneuropathy. Schirmer’s test in patients with Materials: The main group - 50 asymptomatic А и В DPNP was 7 ± patients with diabetic diabetic 2,6 mm and 6±1,8 mm, on the scale polyneuropathy aged 45-75 years of the Рflugfelder patients was (20 male, 30 female). The control graded as 1 and 2 classes. The group - 40 healthy persons of the second group, patients with same age (19 males, 21 females). symptomatic А и В DPNP, the results Methods: Besides standard of Schirmer’s test were 4,7 ± 2,2 mm ophthalmological examination the и 3,6±2,4mm, the scale of the Schirmer’s and Norn’s tests, Рflugfelder patients was graded as 2 meibography were carried out as and 3 classes, in the third group, well. We determined the quantity patients with complications, the and condition of the meibomian results were: 3.8 ± 1.5mm, and class glands over one-third century of 3, respectively. Conclusions: Our eyelid according to Korb findings suggest that meibomian classifications, 2005. Рflugfelder gland dysfunction develops among scale. According to the DPNP all patients with diabetic classification ( Bowker J., 2001 года), polyneuropathy. In the first group of все patients were divided into patients the results of the Schirmer’s groups. The first group (17 patients) test decreased by 53.4% compared – patients with asymptomatic А и В to the standart results, in the second DPNP, the second group (19 – 68,7%, in the third – to 74.7%. The patients) – patients with results of our investigations confirm symptomatic А и В DPNP, the third functional disorders of the (14 patients) – patients with severe meibomian glands in patients with complications of diabetic DPNP. polyneuropathy.

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ISIC-2016 Abstract book Shirgba Sonter Sonte' Jacob AORTIC ANEURYSMS (ABDOMINAL AORTIC ANEURYSM) Research advisor: Goni Kateryna Kharkiv National Medical University Surgery department № 2, Kharkiv, Ukraine

Actuality. An aortic aneurysm is male, stroke, fetal hemorrhages, enlargement (dilation) of the aorta myocardial ischemia, death. greater than 1.5 times normal size. Materials and methods.Case Approx. 36.5 cases of abdominal report: In the surgical department at aortic aneurysms are diagnosed per regional hospital was admitted a 100,000 individuals. It occurs mostly 70yr old man complaints about the in individuals older than 50 years of presence of pulsating tumor age. And they occur in men more formation in the abdominal cavity. than in women with the ratio 2:1. Patient considers himself sick 1.5 The ratio of aortic aneurysms of months ago, after carry a heavy load different localization similar to the he noticed an appearance of following: aneurysm of the pulsating tumor formation. He was abdominal aorta account for 37% of sent for further examination, cases, the ascending aorta - 23% of treatment. the aortic arch - 19% of the Patient had history of CHD, descending thoracic aorta - 19.5%. atherosclerosis, and never controlled The leading causes of aortic and treated hypertension. aneurism are atherosclerosis, Results.After all the required uncontrolled hypertention, inherited test was carried out on this patient or congenital syndromes such as he was finally diagnosed with Marfan syndrome, infection, tobacco abdominal aortic aneurysm. use, blunt or shape trauma. Presently, patient is status is Complications include rupture, moderately severe and is being peripheral embolization, acute aortic prepared for surgery. occlution and aortocaval (between Conclusion: aneurysms the aorta and inferior vena cava) or generally life threatening disease, aorta duodenal (between the aorta especially the abdominal aortic and duodenum), fistulae, colon aneurysms that are asymptomatic at ischemia if ruptured, blue toe the initial stage. Symptoms appear syndrome and cholesterol when the vessels are rupture and it embolization of feet, renal failure, requires surgical attention. bowel obstruction, impotence in

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ISIC-2016 Abstract book Sykykh V.I., Poradiuk K.V. PLASMOTHERAPY AS AN ADDITIONAL THERAPEUTIC METHOD IN SURGICAL AND NON-SURGICAL THERAPY OF CRITICAL LIMB ISCHEMIA PATIENTS Research advisor: Goni Samkha, Kateryna Tahirivna, Aspirant Kharkiv National Medical University Department of surgery №2, Kharkiv, Ukraine

Actuality. Critical limb reconstruction, II – by endovascular ischemia (CLI) value of all vascular surgery, III – non-surgical treatment. problems is above 20%. Results. If we compare the Approximately 2-3% of world`s results of treatment in the group 1.l population suffer from this disease. with group 2.l we can’t find Nowadays increases amount of significant difference. The same if we combined treatment. Many compare group 1.ll with 2.ll. The researches were done to prove the change of physical health in both importance of combined therapy. groups was approximately from The aim of our research is to show 31.15 to 78.47, mental health from the result of combination of surgical 30 to 72.1, pain-free walking from 87 or non-surgical treatment with to 540, pain rate from 5.5 to 0.2. But plasmotherapy. Analysis of the when we compare the results of dynamics of the quality of life during treatment in group 1.lll with 2.lll we one year was made with the can see, that there is significant questionnaire SF-36 with 2 difference. Physical functioning in additional questions - pain-free group 1.lll (according to SF-36) walking distance and level of pain on grows from 31.21 to 45.43 just after VAS. treatment and continue to grow to Materials and methods. 56 68.84 in one year, mental functioning patients with CLI with distal type of grows from 33.81 to 47.43 and to leasion were enrolled in the 66.23, pain-free walking grows from research. Etiology of CLI was 73.3 meters to 94.6 to 268.4, pain atherosclerosis or postthrombotic rate on VAS decreases from 5.3 to 2.4 occlusion. Patients were divided into to 2.4. In group 2.lll physical 3 groups. The first group (26 functioning rate changes from 32.64 patients) is patients, whom to 46.61 to 45.32, mental functioning combined therapy was made. The goes from 36.13 to 44.65 to 42.57, second (30 patients) – treatment pain-free walking changes from 76.4 without plasmotherapy. Each group to 97.3 to 122.4, pain rate changes was devided into 3 groups - I – from 4.9 to 3.1 to 3.2. treated by open surgical Conclusions. According to the results we can say that combination

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ISIC-2016 Abstract book of non-surgical treatment of CLI with was no significant difference plasmotherapy gives patients better between combined and non- results than just non-surgical combined therapy, but the general treatment. In surgical patients there result was better.

Tregub Yevhenii USING OF LAPAROSCOPIC TECHNOLOGIES IN TREATMENT OF PERFORATIVE GASTRODUODENAL ULCERS Research advisor: candidate of Medical Sciences Svirepo Pavel Vasilievich Department of Surgery No. 2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Perforative perforation till hospitalization was gastroduodenal ulcer (PGDU) is a 5,7 ± 2,5 hours. The types of life-threatening complication that peritonitis observed: local - in 49 occurs in 10-15% of patients with (64.4%) patients, general - in 27 peptic ulcer disease (Vasiliev YV, (35.5%); the type of exudate: serous 2003; Zamyatin VA, 2006). - in 53 (69%) patients, purulent - in Nowadays laparoscopic technologies 16 (22%), fibrinopurulent - in 3 are commonly used in urgent (4%) cases. Before the surgery all abdominal surgery, including the patients were investigated using closure of perforated ulcers. classic methods of examination, According to Yermolov AS(2010), according to the Order of Ministry of laparoscopic operation may be Health of Ukraine № 297 from performed in 50-70% cases of PGDU. 02.04.2010. As an indication for Aim: To learn the results of laparoscopic intervention we laparoscopic suturing of PGDU. considered: an acute ulcer Materials and methods: We perforation, size of perforation up to studied the experience of the 10 mm and an absence of other ulcer application of laparoscopic disease complications. technologies for surgical treatment Result: The suturing of of PGDU among 76 patients at the perforated hole was performed in clinic for the period of 2009-2015. simple interrupted suturing technic Age of patients was 19 to 72 years using an atraumatic needle with with an average age of 38.3± 5.6 monofilament thread. A strand of years. The number of males among omentum was sutured over the the sample was 66 (86.8%) persons, stitches. The operation ends with women - 10 (13.1%) persons. The peritoneal cavity sanation and average time from the moment of setting a pipe drain. Duration of 311

ISIC-2016 Abstract book laparoscopic operation was averaged the far periods of 1 to 3 years 42 about 93.5 minutes. (55.2%) patients were examined. After surgery, all patients recieved On a scale Visick excellent and good modern antisecretory and anti- results were obtained in 31 (73.8%) Helicobacter therapy and broad- patients, satisfactory results (erosive spectrum antibiotics. All patients had gastritis, duodenitis) - 10 (23.8%), early physical activity (2nd day) and bad result (relapse of peptic ulcer) - restoration of peristalsis (2nd day). in 1 (2.4%) case. Peroral nutrition started after 3 days. Conclusions: Early postoperative complications 1. Laparoscopic suturing of PGDU is were observed in 3 (3.9%) patients, an effective and safe method of of which pneumonia - in 2 (2.6%), treatment, which allows to conduct a subdiaphragmatic abscess - 1 (1.3%), full revision of the abdominal cavity which was eliminated using and adequately sanitize it. puncture-draining method under 2. Laparoscopic suturing PGDU with ultrasound control. The average further modern anti-ulcer therapy hospital stay was 8.5 days. All may improve the quality of life of the patients continued anti-ulcer patient and leads to a convalescence treatment after hospital discharge. In in 97.6% of cases.

Trofimov Mihail Andreevich DIAGNOSICS AND TREATMENT OF BACTERIAL LIVER ABSCESSES Research advisor: candidate of medical sciences Svirepo Pavel Vasilievich Department of Surgery №2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Bacterial liver BAP in the clinic. All patients were abscesses (BLA) constitute 0.16% divided into 2 groups. The first surgical diseases that need surgical group- patients operated treatment. Traditional open methods conventional open surgical access of BLA treatment lead to post- using the method of Kocher and operative complications and higher middle laparotomy- 25 (39%). The postoperative mortality from 17% to second group- 39 (61%) patients 55%. who were performed minimally Objective: To improve the invasive interventions under the results of surgical treatment of BAP. control of UZI-25 (39%) and with the Materials and methods: use of laparoscopic techniques - 14 during the period 2005-2015y. there (21.8%). have been treated 64 patients with All groups performed a standard set 312

ISIC-2016 Abstract book of clinical, laboratory, radiologic, ultrasound BLA at the sizes of endoscopic, ultrasound and spiral CT abscesses from 1 to 10 cm- 29 research methods. In all cases (74%). Regardless of the number evaluated abscess size, localization of and location of BLA in the remaining liver segments, their number and 10 (26%) patients underwent relative positions of the liver with laparoscopic drainage of abscesses. tubular structures. After surgery, all patients performed Result: In the first group after daily sanitation of abscesses with laparotomy was performed an audit solutions of dekasan and dioksizol of the abdominal cavity, and received antibiotic therapy with retroperitoneal space, performed an broad-spectrum and hepatotropic autopsy and drainage of abscess with orientation. Postoperative double barreled drainage - 8 (32%). complications in this group were: The anatomical and atypical liver pneumonia- 17 (43.5%), exudative resection was performed in 7 (28%) pleuritis - 21 (53.8%). No deaths patients. Indications for liver were observed. The average length resection was considered multiple of hospital stay- 10,2 ± 1,5 bed-days. BAP within the same anatomical Long-term results were followed region and major abscesses (more from 6 months to three years. than 10cm) occupying the whole Relapse of the disease were not anatomy of the liver. Early observed. postoperative complications in this Conclusions: 1. Minimally group were: postoperative wound invasive BAP treatments are effective abscess- 4 (16%), abdominal and safe method which can reduce bleeding- 1 (4%), bile leakage- 1 the number of postoperative (4%), abdominal abscesses- 2 (8%), complications and shorten hospital exudative pleuritis - 3 ( 12%) stay. pneumonia- 5 (20%). No deaths 2.The odds of puncture- draining were observed. The average period interventions is no need for general of hospital stay was 18.5 ± 2 per bed- anesthesia, small trauma, high day. precision drainage, the opportunity In the second group treatment was to continue treatment as an to puncture and drainage under outpatient.

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ISIC-2016 Abstract book Tsopozidis Christos, Borisenko Anastasia, Telezhnyi Andrii CLINICAL CASE: SOMATOPSYCHIC DISORDER IN A FEMALE PATIENT WITH MULTINODULAR EUTHYROID GOITER Kharkiv National Medical University Department of Surgery No. 1 Kharkiv, Ukraine

Actuality. Psychogenic T3 2.2 nmol/L, free T4 16 pmol/L, disorders referred to as nosogenies free T3 8,4 pmol/L, TPOAb 70 mU/l. due to the influence of Thyroid gland psychotraumatic events associated ultrasonography: In the structure of with somatic disorder. In case of the gland the similar type of combined impact of a number of isoechogenous masses of adverse factors, the reaction to the heterogeneous cystic-solid structure disease can become so extreme that with clear boundaries: 14×10×12 its management in the early stages of mm in the middle segment of the therapy seems no less important right lobe, 35×26×37 mm in the than the direct treatment of somatic lower segment of the right lobe, and condition. 43×32×35 mm in the lower segment Materials and methods. We of the left lobe. present a clinical case of Fine-needle aspiration biopsy somatopsychic disorder in a female of the thyroid gland №0402/825. patient with Multinodular goiter, Microscopically: in the midst of the grade 2, euthyrosis. peripheral blood cells and basophilic Complains: enlargement of colloid there are unchanged A-cells the thyroid gland, tickling, sensation in the form of singular layers, and B- of a lump in the throat, choking in cells. No atypical cells were found. horizontal position, general Subtotal resection of the weakness, chills, dizziness, fear for thyroid gland was performed. her life associated with the presence Histological conclusion: the of oncological disease. nodular micro-macrofollicular On physical examination the colloid goiter with secondary thyroid gland is visually identified. changes, microfocal chronic On palpation it is of dense elastic lymphomatoid thyroiditis. consistency, nodular, partly located Results. 2 weeks after receipt behind the breastbone, nodal masses of the histological conclusion the in both lobes of up to 4-5 cm in patient began to hold demands diameter, dense consistency, mobile, against medical staff about the painless, no adhesion to the skin. unreasonable surgery, which caused, Thyroid hormone levels: TSH in her words, her disability, inability 2.4 mIU/L, total T4 102 nmol/L, total to perform daily activity at home and

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ISIC-2016 Abstract book at work. The patient again began in selecting the tactics of complaining to tickle, feeling of a management for such patients due to lump in her throat, choking in development of symptoms primarily horizontal position, general determined by psycho-emotional weakness, tremor, excessive tension. This category of patients sweating, hot flushes, chills, should be followed not only by dizziness. The patient undeniably endocrinologists, surgeons, but the refused to re-consultation. multidisciplinary team, including Conclusion. The above psychiatrists, and psychotherapists. example demonstrates the difficulty

Volik M. THE STIMULATION OF PROSTAGLANDINS IN THE TREATMENT OF ERECTILE DYSFUNCTION Research advisor: Knigavko A., МD, PhD., Professor Kharkiv National Medical University, Department of Urology, Nephrology and Andrology, Kharkiv, Ukraine

Actuality. The incidence of divided into 3 groups. Group 1 erectile dysfunction (ED) is 26.2%. (n=19) used the endocavernosus Today a man suffering from ED injections of Alprostadil in a dosage wants to have a full erection at any of 10 micrograms combined with 1 age and at any time, and also have ml. papaverine. Group 2 (n=20) the ability to control its duration. applied Tadalafil 10 mg (the group of The aim. To evaluate the inhibitors of phosphodiesterase type clinical efficacy and safety of 5 (PDE5) daily. The 3rd group was intracavernosal injection therapy prescribed Tadalafil 10mg daily in with prostaglandin E in comparison combination with rectal with other conservative treatment administration of the drug Vitaprost- methods. Forte which stimulates the Materials and methods. We production of own prostaglandins. were observing 67 patients with Results. It was found that impaired erectile function during 12 among the patients of the 1st group months. The mean age of patients successfully carried out sexual was 56.1±12.3 years. The mean intercourse was registered in 94%, duration of ED was 3.2±2.1 years. in comparison with the 2nd and the The evaluation criterion was ED the 3rd group, which had number of International Index of Erectile sexual acts 78.4% and 92.3%, Function (IIEF), calculated using respectively. The erection was questionnaire. All patients were achieved most quickly in patients of 315

ISIC-2016 Abstract book the 1st group (7±2.6 min), while in 30% and 12.1% - redness of the face, the 2nd gr. – 31, 3±6, 3 min and in 15% and 11, 2% - nasal congestion. the 3rd – 45, 4±12,6 min. The After 20 days of the treatment, the average duration of sexual 42% of the patients of the 3rd group intercourse was the longest in have stopped using Tadalafil daily patients of the 1st gr. - 70±15, 1 min., because of significant improvements and the shortest– in the 2 gr. – 5, of sexual function, changing the 6±2, 3 min. In addition, the synthesis reception on demand. of own prostaglandins in patients of Conclusions. 1. As a result of the 3rd gr. was increased (in average our research it has been proven the of 2.32±0.54 times) what was high efficiency (92, 3%) and good diagnosed by laboratory biochemical tolerability of the combination of analysis of blood. All patients were Tadalafil with prostatotropic drugs examined with the purpose of to improve patients own production identifying side effects: in the 1st gr. of prostaglandins in the treatment of 5, 2% of patients had priapism, ED. 2. The effectiveness of this 15.6% - pain, 10.3% - hematoma, 5, combination is comparable to 2% - development of cavernitis, injections of Alprostadil (94%), 21.7% - fibrotic changes in the penis, while it's significantly safer and has bound during the ultrasound fewer side effects compared to the examination with Doppler. In the 1st and 2nd groups (16,4% versus to 2nd and 3rd gr. 25% and 16.4% of 21.7% and 30%, respectively). patients had a headache respectively,

YaremkоI.Ya., TrofimovaA.V., MelnikovV.V., SapayA.V., TyshkoO.S. FEATURES OF RHE LAPAROSCOPIC CHOLECYSTECTOMY IN PATIENTS WITH PNEUMOCONIOSIS Research advisor: LupaltsovV.I., Corresponding member of NAMS of Ukraine, Professor Kharkiv National Medical University Department of Surgery №3, Kharkiv, Ukraine

Actuality. Tense The aim.To improve the carboperitoneum during results of LCE in patients with acute laparoscopic cholecystectomy (LCE) cholecystitis suffering from in patients suffering from pneumoconiosis. pneumoconiosis, negatively affects Materials and methods. To 49 on the function of the respiratory patients with pneumoconiosis about system, which complicates the acute cholecystitis two types of postoperative period. operations were performed: group 1 - laparotomic cholecystectomy 316

ISIC-2016 Abstract book (LtCE) - 26 patients, 2 group - LCE – of blood pressure - in 1.14 times, and 23. External respiratory function respiratory rate in 1.7 times. In both (ERF); level of saturation (Sa); groups before surgery the average indices of blood gases (РаСО2 and rate of EDVD was 13,5±1,1%, РаО2) and state of the acid-alkaline indicated of hypoxia and arterial balance (pH); endothelial hypoxemia. In group 1 degree of dysfunction markers: endotelein-1 EDVD was slightly reduced (ET-1) and fibronectin (FN) in the (11,4±1,5%), in group 2 degree of blood plasma; level of intra- EDVD decreased to 9,7±0,8%. These abdominal pressure (IAP); degree of EDVD indicies were confirmed by endothelium-dependent vasodilation increased levels of ET-1 to 8,2±0,28 (EDVD) were investigated at 1 and 2 ng/l and FN to 698,7±16,2 mg/l in days after surgery. group 2, which indicates a significant Results. Level of IAP in group 2 deterioration of the broncho- was maximized at 1 day after pulmonary system. In group 1 level surgery, and did not change of FN remained practically significantly in group 1. On unchanged (666,7±19,1 mg/l). admission in all patients it was noted Conclusions. 1. In patients a moderate decrease of lung vital with pneumoconiosis with capacity (LVC) and normal speed respiratory failure (RF) of III degree parameters of ERF. Volume and to perform LCE about acute speed parameters were within cholecystitis is inadvisable because normal limits in patients of group 1. of the high risk of respiratory In group 1 parameters of blood gases dysfunction. did not change. In group 2 - Sa rate 2. To improve the results of decreased in 1.16 times; pH shifted LCE in this category of patients with towards acidosis; РаСО2 increased in RF of I-II degree we must consider 1.2 times against decrease of РаО2 in the level of ET-1 in blood serum as 1.3 times. Also in group 2 heart rate the level of ET-1<1 ng/l is predictive increased in 1.4 times, average level safe for managing of LCE.

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ISIC-2016 Abstract book Zheleznikova M.O. OUR EXPERIENCE IN DIAGNOSTICS AND TREATMENT OF CHRONIC RENAL TRANSPLANT DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE BASED ON THE STUDY OF POLYOMA VIRUS INFECTION Research advisor: Lesovoy V.N., Doctor of Med. Sci., Professor Kharkiv National Medical University Kharkiv Regional Nephro-Urological Center

Introduction. Kidney Regional Nephro-urological Center transplantation is now an accepted was examined 21 patients with renal treatment of patients in end-stage transplant dysfunction within the kidney disease and widely two years after transplantation. Of impleented around the world. Its these, 13 patients were male and 8 restores an acceptable quality of life patients were female. The recipients to such patients. However, receiving was devided into 3 groups:1- renal of immunosupression is the risk transplant recipients which received factors for infection and cancer of the combination of cyclosporine A, graft recipients. The most consistent mTOR inhibitor and risk factor identified across studies is steroids(14,3%); 2- recipients which the overall degree of received the combination of immunosuppression, that leads to tacrolimus, mycophenolate and low-level of acute transplant steroids (47,6%); 3- recipients which rejection. But it is associated with a received the combination of higher incidence of activation latent cyclosporine A, mycophenolate and viruses. Among them can mark steroids(38,1%). polyoma virus infection (BK virus). To determine the structural and Renal damage caused by BK virus functional changes in the kidney comprises progressive transplantat there were performed : tubulointerstitial nephritis and creatinine and urea levels in blood, ureteral stenosis. Viral screening to proteinuria, glomerular filtration facilitate identification of BK virus rate, ultrasound with doppler. Also reactivation is not conducted. The was determined concentration of influence of different tacrolimus. everolimus and immunosuppressive regimens ( cyclosporine levels in the peripheral calcineurin inhibitor, blood. The marker of reactivation mycophenolate, inhibitor mTOR) on polyoma virus infection was the risk of BK replication post- detection of ‘decoy cells’ in urine transplant is discussed. cytology. Material and methods. On the Results. During the study basis of the Department of kidney period polyoma virus infection was transplantation of the Kharkiv detected in 2 patients (9,5%) which

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ISIC-2016 Abstract book received the combination of dysfunction based on the study of tacrolimus, mycophenolate and polyoma virus infection and used steroids within the first years after optimal stategy to prevent their loss. related transplantation. One of these Conclusion. The lack of (4.8%) has an ureteral stenosis. This specific targeted therapies has recipients got the conversion of prompted a pre-emptive active immunosuppression to low dose of surveillance strategy with routine cyclosporine A. During 6 months was screening intervals post observed the increase of glomerular transplantation for polyoma viral filtration rate at 30% (р≤0,05); replication. Reduction or conversion creatinine level in blood decreased of immunosuppression remains the on 40 % (р≤0,05); proteinuria level mainstay of therapy in patients with decreased on 55 % (р≤0,05). In the polyomavirus –associated renal present study we analyzed the transplant dysfunction. incidence of renal transplant

Gillies N.P. MANAGEMENT OF PREMATURE EJACULATION CONCERNED WITH COMPARISONS OF PHARMACEUTICAL AND THERAPEUTIC MANAGEMENT VERSUS SURGICAL INTERVENTION Research Advisor: Knigavko A.V., PhD, Associate Professor Kharkiv National Medical University Department of Urology, Nephrology and Andrology Kharkiv, Ukraine

Actuality. Although clinical lasting effectiveness of therapeutic practice shows an apt to employ (behavioral and technique based) pharmaceutical and therapeutic methods of management, compared modes of management for premature to surgical intervention – selective ejaculation especially in Western and neurotomy; of branches dorsal Central European countries, a penile nerves. comparison to surgical intervention, Materials and Methods. 162 more commonly practiced in Ukraine patients with premature ejaculation and Russia. Where benefit outweighs disorder initially self-managed with risk, adverse effects, sequelae and pause-squeeze techniques and duration of effectiveness of each managed pharmacologically with mode has been compared. SSRI dapoxetin (Priligy) 30mg on- The aim. The primary demand 1 hour before sexual objective of this study was to parallel intercourse. In case simultaneously and adverse effects of ED we added phosphodiesterase-5 pharmacological therapy and non- inhibitors 50mg of Sildenefil. Of the 319

ISIC-2016 Abstract book 162 patients with premature reported improvement following ejaculation disorder, 72 reported dosage adjustment. Total of 88 severe side effects of patients underwent a selective pharmacological treatment, an neurotomy. Intravaginal Ejaculation additional 25 reported ineffective Latency Time was 1.5 - 3.5 min pharmacological management, of (average IELT was 2 min 37 sec). those, 16 still reported Follow-up time was 3 months. ineffectiveness after dosage Average IELT after surgery was 7 adjustment. Those with severe side min 55 sec. effects of headache, epistaxis and Conclusions. Surgical anxiety with loss of libido or no intervention (selective neyrotomia) therapeutic effectiveness, even after is safe, profitable and highly effective dosage adjustment, underwent a method treatment of PE and may selective neurotomy by means of prove to be a last resort for selected dorsal penile nerve ligation traditional treatment and in case of and resection. severe side effects and Results. Of the 25 patients pharmacological ineffectiveness, reporting ineffective instead offering a more permanent pharmacological management, 9 solution for premature ejaculation.

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ISIC-2016 Abstract book Zhurba Y. P., Goncharova N.N., Kozhemyaka K.O. MODERN SURGICAL DECOMPRESSION OF BILIARY TRACT OBSTRUCTIVE JAUNDICE Research advisor: Krivoruchko I.A., m.d. Kharkiv National Medical University Department of Surgery № 2, Kharkiv, Ukraine

Actuality. Obstruction of bile (5 8%), benign tumors of BD - 8 ducts (BD) is one of the important (7.8%). . In 2 patients with problems of modern surgery. pancreatic cancer and cancer of LDP Gallstone disease (GSD) - the most endoscopic biliary stenting was the common cause of it, according to final method of palliative treatment various authors occurs in 8-12% of BD obstruction due to the presence the population of Ukraine. of distant metastases. Another 24 The aim. Analysis of the (23.5%) patients with stages II were results of treatment in patients with performed radical surgery: patients jaundice. with pancreatic cancer and cancer of Matherials and the LDP made 6 pancreatoduodenal methods. Retro - and prospectively resections, 18 - made biliodigestive analyzed the outcomes of 102 anastomoses. Endoscopic patients with OJ in the last 3 years, papillosphinсterotomy (EPST) and men - 38 (37.2%), women - 64 lithoextraction performed in 37 (62.8%) aged 45 to 69 years. In a (36.2%) patients with survey it was found that 26 (25.4%) choledocholithiasis, also held EPST patients had jaundice caused by 23 (22.5%) patients with stenosing cancer processes in hepatobiliary papillitis. In 16 (15.6%) patients zone: BD benign tumors, pancreatic with wedging distal choledochal cancer, cancer of the large duodenal calculus, the inability lithotripsy was papilla (LDP); Other 76 (74.6%) had used nasobiliary BD drainage. In non-tumor genesis of OJ (lithio BD stage II of adequate treatment after obstruction, constrictive papillitis). bilary decompression performed 55 All patients were examined by laparoscopic cholecystectomy, 19 generally accepted methods. All open cholecystectomy of patients applied the principle of choledochotomy and external phased treatment. drainage of choledoch. Conclusions. Results. At I phase of 26 Using endoscopic decompression (25.4%) patients with cancer of the combined with conservative therapy biliary stents were set (8 pieces. in obstructive jaundice enable most French) by endoscopic retrograde patients to prepare for radical prosthetics, including pancreatic surgery with minimal risk of intra- cancer - 12 (11.7%), cancer LDP - 6 and postoperative complications. In

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ISIC-2016 Abstract book some patients with malignant prolongation of the primary jaundice, these interventions can pathological process. carry final character due to the

Zienovieva O. APPLICATION OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR DIABETICS WITH MACULAR EDEMA Research Advisor: Dobritsa Y., PhD, Associate Professor Kharkiv National Medical University Department of Ophtalmology, Kharkiv, Ukraine

Actuality. A new method of with net Amslera, diagnostic with the treatment of diabetic macular edema Amsler grid, auto perimetry, optical (DME) based on the local coherence tomography (OCT) of suppression of vascular endothelial retina (macula report) via “Topcon growth factor (VEGF) is widely 3D OCT-1000 MK2 (ver3.51)”. Visual distributing in clinical practice. The acuity decreased for all patients mechanism anti-VEGF therapeutic where average visual acuity was realizes by several ways: direct 0,208. On the grid Amslera relative binding to VEGF, block the central scotoma within 15 ° from the expression of its genes or receptors. point of fixation and central The Aim: To investigate the metamorphopsia have been found in effectiveness of intravitreal all investigations. Indications with injections of aflibercept (“Eylea”) in the OCT: intraretinal cysts (single the treatment of DME in patients and multiple; various sizes; foveal with diabetes type II. and parafoveal localization), diffuse Materials and methods: 12 edema of the retina with an increase patients with DME were monitored in foveal central subfield (FCS) (6 with Pre-proliferative retinopathy, thickness (from 320μm to 780μm). 6 with non-proliferative The average (FCS) thickness was retinopathy). All patients had type II 553,3μm. Intravitreal aflibercept of insulin dependent diabetes with injections were carried 2 ml dose subcompensation carbohydrate once a month and a half. 5 patients metabolism, age from 57 to 73 years; were treated with 3 injections of 7 women and 5 men. The “Eylea”, 4 people received 4 observation period was from 10 injections and other 3 got 2 September 2015 to 10 March 2016. injections. Ophthalmic examination methods: Results: all 12 patients have visometry, ophthalmoscopy, noted increase of average visual tonometry, biomicroscopy, study acuity to 0,381, decline DME to FCS 322

ISIC-2016 Abstract book thickness 287,8μm , significant promotes regression of edema, reduction and even absence of decreases FCS thickness that relative central scotoma. gradually improves vision diabetes Conclusions: application of patients. intravitreal aflibercept injection

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ISIC-2016 Abstract book

THERAPY

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ISIC-2016 Abstract book Abugu Nnadozie Livinus A REVIEW PAPER ON INTRAUTERINE GROWTH RESTRICTION AND IMPLICATIONS ON THE CARDIOVASCULAR SYSTEM Department of internal medicine #2, clinical immunology and allergology Research advisor Titova Anna

Important role in pathogenesis nitrosotiol in groups 60-75 and 75 of chronic heart failure (CHF) has a years, in men and women, depending disturbance of vasodilative function on presence of HD and DM in of endothelinum, that determinates anamnesis meanings of this by level of synthesis and metabolism methabolite had no difference. of nitric oxide (NO). S-nitrosotiol – Nitrate level in patients with II and complex, that made as a result of III FC of CHF was significantly less of including NO into dinitrozol those in control (р<0,05; р<0,05). complexes of iron with thiol lygands, Nitrites level in patients with CHF II forming a physiologically oxidation FC was lower (р<0,05), in CHF III FC that reflect the intensity of it’s – had no difference from normal one. synthesis. Level of nitrates and nitrites in CHF Aim of investigation- III FC was significantly higher CHF II determination of peculiarities of NO FC(р<0,01; р<0,05). At the age of 75 metabolism in patients of elderly age years level of nitrates and nitrites with CHF. were significantly lower than at the Matherial and methods : 68 age of 60-75 years (р<0,05; р<0,05). patients with ischemic heart disease Indices of NO were significantly of age from 60 to 92 were examined. higher in patients with HD and DM CHF of II functional class (FC) was comparing to patients without HD determinated in 44 (64%), CHF of III and DM in anamnesis (р<0,05). FC–in 24 (35%) patients (NYHA). Conclusion : Depression of 29% had hypertensive disease (HD), NO metabolites formation testify 19% patients diabetes mellitus about decreasing of intensity of NO (DM). Nitrates and nitrites were metabolism and reflects physiologic determinated in serum by method of and pathologic, that caused by CHF, Griss’ diasoreaction with endothelial dysfunction. In CHF III determination of nitric junction. S- FC, HD and DM in anamnesis were nitrosotiol was determinated by determinated significantly higher fluorimetric method. rates of nitrites and nitrates. This Results: there was found a fact can be related with induction of significantly decreasing of S- iNOS with increasing formation of nitrosotiol level comparing to control NO what due to CHF can be caused group. Comparing level of S- by growing ischemia, due to HD – 325

ISIC-2016 Abstract book increased endothelial disfynction such way, changes of vasodilative and high blood pressure, due to DM – function in patients of elderly age metabolic disturbances, which depends on severity of CHF, age of connected to dysbalance of pressore the patient and presence of and depressor acting of insulin. In polymorbide background.

Abugu Nnadozie Livinus, Etukudo Ime-Obong NO METABOLISM IN PATIENTS OF ELDERLY AGE WITH CHRONIC HEART FAILURE Research advisor: Associate Professor Titova Anna Department of internal medicine №2, clinical immunology and allergology Kharkiv National Medical Iniversity

Kharkiv, Ukraine (DM). Nitrates and nitrites were Actuality: Important role in determinated in serum by method of pathogenesis of chronic heart failure Griss’ diasoreaction with (CHF) has a disturbance of determination of nitric junction. S- vasodilative function of nitrosotiol was determinated by endothelinum, that determinates by fluorimetric method. level of synthesis and metabolism of Results: there was found a nitric oxide (NO). S-nitrosotiol – significantly decreasing of S- complex, that made as a result of nitrosotiol level comparing to control including NO into dinitrozol group. Comparing level of S- complexes of iron with thiol lygands, nitrosotiol in groups 60-75 and 75 forming a physiologically oxidation years, in men and women, depending that reflect the intensity of it’s on presence of HD and DM in synthesis. anamnesis meanings of this Aim of investigation- methabolite had no difference. determination of peculiarities of NO Nitrate level in patients with II and metabolism in patients of elderly age III FC of CHF was significantly less of with CHF. those in control (р<0,05; р<0,05). Matherial and methods: 68 Nitrites level in patients with CHF II patients with ischemic heart disease FC was lower (р<0,05), in CHF III FC of age from 60 to 92 were examined. – had no difference from normal one. CHF of II functional class (FC) was Level of nitrates and nitrites in CHF determinated in 44 (64%), CHF of III III FC was significantly higher CHF II FC–in 24 (35%) patients (NYHA). FC(р<0,01; р<0,05). At the age of 75 29% had hypertensive disease (HD), years level of nitrates and nitrites 19% patients diabetes mellitus were significantly lower than at the 326

ISIC-2016 Abstract book age of 60-75 years (р<0,05; р<0,05). fact can be related with induction of Indices of NO were significantly iNOS with increasing formation of higher in patients with HD and DM NO what due to CHF can be caused comparing to patients without HD by growing ischemia, due to HD – and DM in anamnesis (р<0,05). increased endothelial disfynction Conclusions: Depression of and high blood pressure, due to DM – NO metabolites formation testify metabolic disturbances, which about decreasing of intensity of NO connected to dysbalance of pressore metabolism and reflects physiologic and depressor acting of insulin. In and pathologic, that caused by CHF, such way, changes of vasodilative endothelial dysfunction. In CHF III function in patients of elderly age FC, HD and DM in anamnesis were depends on severity of CHF, age of determinated significantly higher the patient and presence of rates of nitrites and nitrates. This polymorbide background.

Ahmed Raliat Balogun INDUCTORS OF ENDOGENOUS INTERFERON IN THERAPY OF ECZEMA Research advisor: Dashchuk A. M., professor Department of Dermatology, Venereology and AIDS, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Eczema is one of the most of eczema & 21(60.9%) had severe common chronic dermatosis, the form. Based on the SCORAD index, incidence of which has been growing patients were divided into: those steadily. This is primarily due to the with easy (40 points)-14 patients complexity and versatility of (30.4%), moderate (40-60 points)- pathogenic mechanisms, among 20 patients (43.5%) &severe course which great importance is attached (>60 points) -12 patients (26.1%). to immune disorders. All patients had thorough The aim is to study the effect of examination and were divided into inducing endogenous interferon and two groups of 23 each. Patients in some immunological parameters on the control group received basic skin areas during eczematous therapy: antihistamines, sedatives, process. calcium, vitamins & weak topical Materials and methods. The steroids. Patients in the study group study involved 46 patients with received amizon 0.25g 3x/day & chronic eczema (41 males &5 basic therapy. females, from age 22-64 years).18 Results. Before treatment, all patients (39.1%) had limited forms the patients had a decrease in the 327

ISIC-2016 Abstract book content of CD 3 , CD 4 and CD 19- remission was achieved in 9-13 days lymphocytes (cellular immunity) and in 5 patients, 14-18 days in 5 simultaneous decrease in humoral patients & 19-22 days in 4 patients. immunity (more profound in 18 months follow up of the patients patients with severe forms). After showed that average duration of treatment, Clinical recovery was clinical remission in the study group seen in 18 patients (78.2%), was 10,3+ 0,13 months & in the significant improvement in 5 control group- only 5,1+ 0.28 patients (21.8%) and absence of months. deterioration in all the patients Conclusion. It should be noted irrespective of the presenting that patients with true chronic severity of eczema. Clinical remission eczema showed violations of their was reached in 7-8 days in 4 immune system. However patients, 9-13 days in 10 patients. introduction of amizon with basic For patients in the control group therapy lead to the correction of who received only basic therapy, patients’ immune system and clinical recovery was seen in 14 marked improvement of their health, patients, significant improvement in with no side effects detected. These 8 patients, moderate improvement in results showed the feasibility of 1 patient and absence of introducing amizon in the complex deterioration in all patients. For therapy of true chronic eczema. patients in study group clinical

Albashir Ayat, Mohammed Ahmed MOST PRONOUNCED PSYCHOLOGICAL SYMPTOMS ASSOCIATED WITH IBS Pesearch advisor: As.prof. Titova Anna Kharkiv National Medical University Department of Internal Medicine #2, Clinical immunology and Allergology

Actuality. Irritable bowel are abdominal pain, flatulence, syndrome (IBS) is a functional bloating, constipation, diarrhea, or disorder affecting the large intestine both. specifically the colon causing The aim. This thesis is to highlight different physiological and the most pronounced psychological psychological symptoms that symptoms associated with IBS in age manifest by influence of external category from (20-30 years old) as factors including life style, diet, this category are mostly of junior psychological state, and others. Most adults whom are exposed to daily life well-known physiological symptoms struggles. Most of those who are 328

ISIC-2016 Abstract book under this category are either - Being emotional (3.1%). university students or daily workers. - Being anxious (1.4%). Material and methods. - Low energy (0.8%). Researches has been done by using a Around 70% of patient declared that questionnaire method of collecting emotional distress is usually the information from a group of 60 cause that aggravate the people under the age category from physiological symptoms of IBS (20-30 years old), asking about making it harder for them to manage different psychological symptoms and deal with the symptoms, while manifested in the last 6 months, in 30% of patients stated that the which whether they manifest on physiological symptoms of IBS are almost a daily base, manifest unpredictable in most of the time sometimes, rarely, or never. whether that it can appear at any time while it is accompanied by a physiological eating in a restaurant or at a social symptoms or that the physiological gathering. symptoms are unpredictable. Conclusion.the most pronounced Results.The results revealed that psychological symptoms that is participants most pronounced associated with Irritable bowel psychological symptoms that syndrome is stress and it is usually manifested during the last 6 months accompanied by physiological were are follow from highest to symptoms like abdominal pain, and lowest: bloating. - Stress (40%). The best way to reduce the - Mood swings (27.1%). severity of these symptoms is by - Reduced ability to concentrate changing the life style and avoiding (13.6%). stressful life manners. Diet and - Major changes in eating habits exercises can also help in relieving (8.4%). these symptoms in which IBS will no - Depression (5.6%). longer be a suffer for the patients.

Alhaad Mustafa Mohamuud, Knigavko A. SEXUAL REHABILITATION AFTER DIFFERENT TYPES OF URETHOPLASTY Department of Urology, Nephrology and Andrology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Urethral stricture penis tip. Strictures are managed disease is defined as a narrowing of surgically, either by endoscopic the urethra between its origination incision or open surgical at the bladder and its outlet at the reconstruction, which often involves 329

ISIC-2016 Abstract book a graft to substitute for the diseased on sexual dysfunction after urethra. Outcomes of urethral urethroplasty, although the results reconstruction surgery have are far from uniform, there is a trend traditionally focused only on for a higher incidence of sexual urodynamic parameters on the dysfunction after anastamotic repair improvement of urination function (AR) compared to free graft and ignore negative impaction of urethroplasty (FGU) for bulbar posterior effect of surgery on sexual urethral strictures. Other authors did function. Surgical approaches not find a significant decline in involving the external genitalia have erectile function nor did they find a an unmistakable noxious potential in difference between AR and FGU. several domains of sexual function. A Overwhelming majority of studies successful urethral reconstructive conducted in the period of 2012- procedure leads to rehabilitation of 2015 did not find statistically the patient back into a healthy sexual significant degradation of erectile life. function after urethroplasty The aim to perform a systematic compared to baseline. review of scientific literatures with In order to minimize this potential the aim to evaluate the results problem, several authors have regarding the sexual sphere after proposed some minimally invasive various types of urethral surgery and procedures in an attempt to to identify impacts of sexual maximally preserve structures rehabilitation. involved in ejaculatory mechanics. Material and methods: Urethral Conclusions: AR is associated reconstructive surgery is a long-term with a transient decline in erectile cure for urethral stricture disease in and ejaculatory function (EF). This most patients with success rates in was not observed with FGU. Bulbar most series greater than 90%. urethroplasty is likely to provoke International Index of Erectile changes in genital sensitivity. Function (IIEF) questionnaire pre- Overall, the men did not report a operatively and 6 months post- decline in erectile function or sexual operatively is useful for evaluating drive after surgery however; older sexual function after urethroplasty. men might have a higher incidence of Concerning erectile and ejaculatory erectile dysfunction after surgery. dysfunction, potentially injured Although older men might have structures in the course of higher rates of erectile dysfunction urethroplasty include several arterial after surgery than younger men, structures, nerve branches and however EF probably recovers with eventually myogenic components. An time. increasing number of papers report

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ISIC-2016 Abstract book Al-Trawneh O.V. THE THERAPEUTIC STRATEGY IS A COMBINATION WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS Kharkiv National Medical University, Kharkiv, Ukraine Department of clinical pharmacology Scientific supervisor: professor Bobronnikova L.R.

Introduction. Arterial patients (n = 23) got the basic hypertension (AH) is often comorbid antihypertensive therapy with ACE with associated type 2 diabetes inhibitors and selective β - mellitus (T2DM). These patients adrenoblocker; the 2nd group (n = belong to high cardiovascular risk 19) received additional lipoic acid group and classified by early onset treatment (Berlithion) in daily and atherosclerosis progression and dosage to 600 mkg per day and cardiovascular complication. In rosuvastatin 10 mg once per day. connection therewith, differential The statistical analysis was correction is an important and performed by using Microsoft Excel promising subject in a therapy of program, Statistica for Windows. given group of patients. Results. BMI hadn’t veracious Aim of the present research is distinctions (p>0,05) influenced by to estimate the effectiveness of the therapy. The standard therapy for combination therapy of patients with patients of the 1st group hasn’t AH comorbid with associated T2DM. disclosed the material effect the lipid Materials and methods. 42 AH spectrum index of blood serum: low- patients of II stage and 2nd phase of density lipoprotein cholesterol level T2DM were examined. The average falling far short of the target values age of the patients was 54,7 ± 5,4 (4,79±0,34 mmol/l), while the index years. The control group (n = 20) for patients of the 2nd group was was comparable in age and sex. It 3,29±0,25 mmol/l, the total was studied the carbohydrate cholesterol of blood serum – metabolism, index HOMA-IR, accordingly was 6,7±0,16 mmol/l disturbance in lipid metabolism, and 5,5±0,28 mmol/l (control - oxidative stress index levels of 4,74±0,15 mmol/l), triglyceride malondialdehyde (MDA) and 1,29±0,64 mmol/l and 1,26±0,87 superoxide dismutase (SOD). The mmol/l, (control - 1,25±0.52 body mass index (BMI) of the mmol/l) (р<0,05), lipoproteins of patients of group 1– 27,15; group 2 – high 1,28±0,5 mmol/l and 1,38±0,32 29,13. mmol/l. MDA level of blood serum To depend upon the type of for 2nd group and control was lower treatment, the patients were divided as (p<0,001), but SOD activity of into groups: the 1st is a group of blood serum was lower in

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ISIC-2016 Abstract book comparison with control (p<0,001). improved the carbohydrate and lipid HOMA-IR index for patients of the metabolism indexes, as well as 2nd group accordingly was 4,46±0,3 indicators of antioxidant stress, и 3,45±0,5, (р<0,05). which can significantly reduce the Conclusions. Prescription of risk of cardiovascular complications lipoic acid medicine and rosuvastatin in these patients. in daily dosage to 10 mg per day

Balatiuk I.A.1, Hladkykh F.V.2, Yavorskyi O.M.3, Sokyrko M.V.2 CLINICAL ASPECTS OF THE TREATMENT OF CHARCOT OSTEOARTHROPATHY 1Ukrainian Military Medical Academy Kyiv, Ukraine 2 Vinnitsa National Pirogov Memorial Medical University Vinnitsa, Ukraine 3Danylo Halytsky Lviv National Medical University Lviv, Ukraine Charcot osteoarthropathy (sharp, chronic, phase of (CО) at a diabetes mellitus is the complications) and have complex most threatening complication of approach. Thus patients require a syndrome of diabetic foot (SDF), supervision and treatment at once resulting in irreversible disability for a few specialists, including a and, as a result – to the fall-off of surgeon not only, and and quality of life of patients. Today CО is endocrinology, traumatologist, determined as the disease of bones orthopaedist. Consultation of and joints, characterized by pain or vascular surgeon is also needed, as by painless destruction of bones and as a rule CО is accompanied by joints of extremities, what be going violations of circulation of blood. on on a background loss of sensory In a sharp phase treatment is innervation. begun with the complete or partial RESEARCH. From data of open statics and dynamics mechanical literary sources of electronic base of unloading of the staggered extremity PubMed to study the modern (orthopaedic shoe and special off- methods of treatment of diabetic loading insoles; imposition total osteoarthropathy. gipseous longets; the special MATERIALS AND METHODS. orthopaedic shoe ,with holding The criterion of selection were insoles adaptations, limiting motions publications for period 2010-2015, in a talocrural joint at walking, that answered the canons of orthezis) on 8-12 weeks. evidential medicine. Roentgenologic control is carried out RESEARCH RESULTS. The in 2-3 months, with the purpose of analysis of modern literary sources control after cicatrization of breaks showed that curative measures at CО and exposure of new deformations of depend on the phase of development bones. 332

ISIC-2016 Abstract book In a chronic phase treatment is At presence of complications begun with providing of stability of originally optimize the flow of joints (with limitation or complete diabets. It is further correct to freezing of motions in them) by conduct local treatment (treatment means of surgical methods of wound, antibacterial therapy, (arthrodezys, eczostozectomy, the aseptic bandage) with the use of plastic arts of the Achilles tendon, system antibacterial therapy and reconstructive operations on a bone- unloading of the staggered area of ligamentary vehicle feet). Also foot. reduce statics and dynamics CONCLUSIONS. The analysis of pressure on the different areas of literary data showed that CО is the sole part of foot (with the purpose of most heavy pathology developing at prophylaxis of on ulcerogenezis a SDF. Complication of treatment foot) by means of the special consists in many-sided nature orthopaedic shoe with insoles. pathogeny resulting in involving of Podotherape treatment feet and practically structural all of the tools podiatric care of foot in a cabinet the of foot with the loss of basic "Diabetic foot" plays one of leading functions. For treatment CО is used roles the prophylaxis of the complex approach sent to the ulcerogenezis on a foot. No less prophylaxis of complications first of important is educating patiens to the all. The important stage of treatment podiatric care of foot. If necessary is the mechanical statics and use preparations influencing on dynamics unloading of foot. No less metabolism of bone fabric. important is educating of patient to the podiatric care of foot.

Berezhniy H.G., Shaposhuk V. MORPHOFUNCTIONAL STATE OF HEART AND CAROTID ARTERIES IN MALES AGED 18-25 YEARS WITH DOCUMENTED HIGH BLOOD PRESSURE Research advisor – Professor Knyazkova I.I. Department of Clinical Pharmacology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. The results of of the participants had at least 1 risk epidemiological studies suggest, that factor for cardiovascular disease. the incidence of the disease among According to a meta-analysis (2013) young people from 5 to 14 %. In the cohort studies, which included 5785 NHANES study (1999-2006 yr.), participants aged 20-38 years, which which included 2,587 of young have been studied indicators of ideal people aged 20-45 years, two-thirds cardiovascular health and their 333

ISIC-2016 Abstract book relationship with intima-media surveyed, II - 18.4% and III - 2,0%. It thickness of the carotid arteries, was noted that the frequency of confirmed that the ideal normotonic males was 16,6%, 57,5% cardiovascular health found only 1% had hypertension, unstable of young adults. hypertension – 25,9%. Hypertension The aim of the study was to in 59,2% of cases was expressed by investigate the structural and isolated systolic hypertension, and functional state of heart and carotid systolic-diastolic hypertension in arteries in males aged 18-25 years 40,8%. Pts with isolated clinical with different levels of blood hypertension (ICH) and pressure (BP). hypertension had significantly higher Materials and methods. A total values of interventricular septum of 120 males aged 18-25 years thickness (by 16,7%, p<0,05 and (mean age 23,5 ± 0,34 years) with 22,2%, p<0,01), LV walls thickness documented high BP were included. (by 11,2%, p<0,05 and 20,2%, Exclusion criteria were: secondary p<0,01), LV mass index (by 16,9%, forms of hypertension, professional p<0,05 and 26,8%, p<0,01), and the athletes treated with relative wall thickness (by 16,7%, antihypertensive drugs less than 3 p<0,05 and 26,9%, p<0,01) months before the study. The control compared to controls. Concentric LV group consisted of 20 healthy males. remodeling was found in 25.8% of Clinical measurement of blood pts with ICH, and in 59.4% of pts pressure, ambulatory blood pressure with hypertension. Concentric LV monitoring, Doppler hypertrophy was detected in 4,3% of echocardiography to estimate left pts with hypertension. In pts with ventricular (LV) diastolic function, ICH and hypertension the E/A ratio ultrasonography of the was 9,6% (p<0,05) and 18.2% (p brachiocephalic arteries were <0,05) lower than in the control performed. group. In this case, the differences Results. In the studied group of were due to the higher values of males aged 18-25 years there was a wave A in hypertension. The values high prevalence of such risk factors of intima-media thickness (IMT) as: smoking (56.6%), dyslipidemia were within the normal range (0.9 (20.8%), abdominal obesity (18.3%). mm). At the same time early wall Wherein 1 risk factor was detected thickening of blood vessels was in 31.6% of surveyed, 2 risk factors found. With an increase in BP there in 28.3%, and 3 or more in 21.6%. was a significant (p<0,05) increase in Criteria for metabolic syndrome the IMT by 13.3% and 20% in pts were found in 15% of patients (pts). with ICH and hypertension, Clinically stable hypertension was respectively. This corresponded to defined in 81.7% of cases. Increase in impaired arterial elastic properties, clinical BP of I degree had 79,6% of as evidenced by a reduced 334

ISIC-2016 Abstract book distensibility coefficient (DC) (by Conclusions. 1. In a population 33,3%, p>0,05 and 41,7%, p<0,05) of male aged 18-25 years with a and the elastic modulus (by 13,9% history of hypertension the main risk p> 0.05 and 30,5%, p<0,05) increase factors are: smoking, abdominal in the Young's modulus (by 16,7%, obesity and dyslipidemia. 2. Young p> 0,05, and 26,2%, p<0,05) and the hypertensive males have LV Peterson’s modulus (by 8,3%, remodeling and impaired diastolic p>0,05, and 41,6%, p<0,05) of the function, as well as increased carotid common carotid artery compared IMT and arterial wall stiffening. with the control group.

Borovyk K.N., Saiika A.I. THE FEATURES OF THE QUALITY OF LIFE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CONCOMITANT OBESITY Research Advisor: Assistant Professor Ryndina N.G.. Department of Internal medicine №2 and Сlinical Immunology and Allergology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Acute myocardial were comparable in age. The quality infarction (AMI) is one of the most of life assessment was conducted by dangerous forms of ischemic heart a non-specific questionnaire «SF-36 disease. The risk of AMI increases Health Status Survey». Statistical dramatically in patients with data processing was carried out concomitant obesity. The research of using «Statistica 8.0» statistical the quality of life is a complex software package, «Microsoft Office medical and social problem of the Excel». modern health care system. Results. The analysis of the The aim of our research was data showed the significant to study the quality of life in patients reduction of points for the role with acute myocardial infarction functioning parameters (RP) by depending on the presence or 75.3%, vitality (VT) - by 48.3%, and absence of concomitant obesity using role-emotional (RE) functioning - by the SF-36 questionnaire. 64.1% in patients with acute Materials and methods. The myocardial infarction with the study included 60 patients with AMI. concomitant obesity compared with The first group consisted of 35 the non-obese patients. These results patients with concomitant obesity, confirm the inverse correlation the second - 24 patients with normal between body mass index of the body weight. Patients in both groups 335

ISIC-2016 Abstract book patients and the above parameters of myocardial infarction compared with the quality of life (p <0,05). patients who have normal body Conclusions. The presence of weight taking into account physical obesity is associated with a and psycho-emotional components significant decreasing of the quality of health. of life level in patients with acute

Butova Ievgeniia STATINS APLICATION FOR THE TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS TYPE 2 Research advisor: Prof. Bobronnikova Lesya Clinical pharmacology department Kharkiv National Medical University

Actuality. A combination of arterial echocardiography and ultrasound of hypertension (AH) and diabetes common carotid arteries with mellitus (DM) type 2 is an especially measurement of the thickness of the serious problem, which is related to intima-media complex of the the earlier development of target common carotid artery (IMC CCA) organ damage and subsequent Results. At the end of 12 weeks cardiovascular events. of treatment, including a The aim. To evaluate an personalized diet, physical exercises, efficacy of metformin and atorvastatin 20 mg/day and atorvastatin in patients with AH and metformin 1000-2000 mg/day, it DM type 2. was revealed decrease of HOMA-IR Materials and methods. In our level by 4.5% (p <0.05), glycosylated research took part 64 patients (30 hemoglobin 16.44% (p <0.001), men and 34 women) with DM fasting plasma glucose by 13.9% (p compensated type 2 in combination <0.001). Total cholesterol decreased with AH stage II and 2 degrees. The by 2.9%, triglycerides by 11%, HDL average age of the patients was 54,5 content increased by 20.9%, LDL ± 4,5 years. The control group was decreased by 12,8% (p <0,001). 20 healthy individuals. There were Body weight decreased by 2.38%, evaluated anthropometric indicators, BMI by 1.6%, waist circumference index HOMA-IR, examined by 1.17% (p <0.05). The level of carbohydrate and lipid metabolism, adiponectin decreased by 1,5 times circulating adiponectin (р<0,05). IMC CCA decreased by 33% concentrations in blood’s plazma, the (p <0.01). It was observed a decrease 336

ISIC-2016 Abstract book of systolic and diastolic pressure by resistance, lipid metabolism, 14.5% - 13.7% (p <0.01). adiponectin’s level, the thickness of Conclusions. 12-week therapy the wall of the carotid arteries. There in patients with AH and DM type 2 was observed a decrease of body with atorvastatin 20 mg/day and weight, which helps to reduce a metformin in a dose of 1000-2000 blood pressure level and improve a mg/day can improve the diastolic myocardial function. carbohydrate profile, insulin

Chekhovskoy A.O. EARLY MARKERS OF ATHEROSCLEROSIS MANIFESTATION IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE Supervisor -Sytnik K.A. Internal Medicine Department №1 Kharkiv National Medical University, Kharkiv, Ukraine

Actuality: Nonalcoholic fatty intima-media complex (IMT) of the liver disease (NAFLD) is an common carotid artery was important factor in the development determined by duplex of atherosclerosis. It’s proved that ultrasonography, B–mode. As NAFLD promotes the development of standards were used IMT values of atherosclerosis, even in category of less than 0.9 mm. people with a lack of signs of Results: The patients ranged metabolic syndrome, which makes it in BMI from 21.5 to 32.4 kg/m2, the necessary to develop effective average value in the group of diagnostic measures for the early patients with NAFLD-26,1±0,9 detection of atherosclerosis in these kg/m2, in the control group - 23,7±0 patients. 8 kg/m2. Waist circumference in The aim: to reveal the patients with NAFLD averaged in markers for determining the pre- interval 95,0±3,1 cm and was clinical manifestation of significantly increased compared atherosclerosis in patients with with the control group-79,3±2,2 cm. NAFLD. Hip girth did not differ in groups. Materials and Methods: The During the study of research involved 70 patients with carbohydrate metabolism has been NAFLD at the age of 31-57 years. The found the increase of HOMA-IR index control group consisted of 30 almost in the main group (5,8±2,39), control healthy individuals. Conducted a group-2,2±0,54. Insulin study of anthropometric parameters, concentration was (19,6±2,8) mU/ml carbohydrate metabolism, lipid in the study group compared to the metabolism. The thickness of the (4,1±0,9) mU/ml in the control 337

ISIC-2016 Abstract book group (p<0,01). Fasting glucose Conclusions: In patients levels were not significantly different with NAFLD revealed violations of between the groups, and was carbohydrate and lipid metabolism: respectively (6,3±1,2) and (5,6±0,9) insulin resistance, increased mmol/L. concentrations of pro-atherogenic During the study of lipid lipid fractions; metabolism in patients with NAFLD Patients with NAFLD are at was identified proatherogenic serum high risk of early atherosclerosis lipid profile. There was a significant developing, which is confirmed by increase in the levels of total the increase IMT of the common cholesterol-6,3±0,8 mmol, TG- carotid artery; 2,7±1,4 mmol/l, LDL-to 3,7±0,2 Changes in IMT of the carotid mmol/l versus the control group. arteries are identified for The levels of the HDL-1,80±0,16 asymptomatic patients without a mmol/L in the study group were history of coronary artery disease significantly lower than in healthy clinical manifestations; individuals. In the group of patients Ultrasound measurement of with NAFLD increase in IMT over 0.9 IMT can be recommended for early mm were detected in 33(47.1%) detection of atherosclerosis in persons, whereas only 2 (6.6 %) in patients with NAFLD . the control group.

S.V.Demianiuk, O.A.Viltsaniuk, I.M.Koval DIAGNOSTIC OF THE LIVER FIBROSIS SEVERITY IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES ACCORDING TO ELASTOMERY RESULTS Department of Propedeutics to Internal Medicine Vinnitsa, Ukraine Vinnitsa National Medical University named after M. I. Pirogov

Introduction. The problem of Assessment of severity of liver diagnostics of complications that fibrosis using elastometry allows us develop against the background of to determine the degree of liver the experience of the liver fibrosis, which is a basic indicator of parenchyma remains one of the severity criterion and prognosis of topical problems of modern liver diseases (Hagan.With., Isakov V. medicine. Despite modern medical A., 2010, Didenko V. I., 2013). advances, the number of cases of Aim: to determine the severity complicated liver parenchyma of changes and the degree of fibrosis diseases in the world continues to of the liver parenchyma in patients grow and is accompanied by a high with different pathologies of the liver mortality rate (Don C. Rockey, 2009). 338

ISIC-2016 Abstract book parenchyma according to the results etiology - 44,4±13,6 years, in of elastomery. patients with cirrhosis - 54,7±13,8. Materials and methods: we As the viral hepatitis C and B are the analyzed 476 elastometry results, most common diagnoses was which were performed on the basis decided to analyzed elastomery of the Military medical clinical center results in these groups of patients. of the Central region in Vinnitsa Using a METAVIR score of fibrosis during 2013-2015. Among the stages in patients with viral hepatitis examined patients there were 240 C it was established that: 96 people men (50.5%), women – 236 (49.5 had a 0 stage fibrosis, 1 stage – 70 %). The average age of patients was people, 2 stage – 43 people, 3 stage - 42.5±14.3 years. 24, 4 stage – 23, clinical cirrhosis – Results of research:It was 15 people, it was noninformative in found that among the 476 patients: 20 people. According to the patients with chronic viral hepatitis METAVIR score for fibrosis stages in C – 291 people (50,8%), chronic viral patients with viral hepatitis B it was hepatitis B – 82 people (21.8%), established that : 2 people had 0 hepatitis of unknown etiology – 64 stage fibrosis, 1 stage – 3, 2 stage – 5 people (6,38%), cirrhosis – 27 (4.5 people, 3 stage - 21, 4 stage – 28, %), and their combinations – in 6 clinical cirrhosis – 16, cases, which amounted to 1.1%. In noninformative in 7 people. the analysis of the average age of Conclusion :Considering the patients with the most widespread obtained data, it can be argued that pathology of the liver parenchyma this method is highly informative for was found that the average age of diagnosis of stages of hepatic patients with chronic hepatitis B is fibrosis, as well as it is safe for 37.3±13,7 years, with chronic medical staff and does not require hepatitis C is 38.2±12,6 years, in additional costs for handling tools patients with hepatitis of unknown and equipment.

T. M.Pryadka, S.R. Dutchak STATUS OF OXYGENATION AND VENTILATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME Supervisor: prof. I.I. Titov Department of Anesthesiology and Intensive Care Ivano-Frankivsk National Medical Universit

Background. Obstructive sleep by numerous episodes of shortness apnea (OSA) - a potentially life of breath during sleep, in which threatening condition that is marked blood oxygenation indexes are 339

ISIC-2016 Abstract book reduced. Negative cardiovascular 43.8 ± 2.6 mm Hg, and maximum effects - fibrillation, bradycardia, 58.2 ± 3.4 mm Hg; the average hypertension, and hypertensive number of oRDI -19.8 ± 1.1 / h., and crises are also observed. The most the maximum 66.8 ± 3.5 / h .; serious results of OSA are stroke, Maximum heart rate was 142.6 ± 4.9 myocardial infarction, ventricular beats / min., and the minimum- 44.5 fibrillation and death in sleep. The ± 2.3 beats / min. These indexes key markers in the diagnosis of OSA show the pronounced obstructive are a disorder of oxygenation, respiratory disorders, which require respiratory function and sleep treatment. During night "therapy", in fragmentation. which patients were performed the The purpose and objectives of non-invasive (mask) respiratory the study was to study the changes support in continuous positive of oxygenation and ventilation in airway pressure (CPAP) respirator patients with OSA during the «Somno balance Auto» (Weinmann, "diagnostic" and "therapeutic" night. Germany), SpO2 averages were 94.2 Materials and methods. The ± 1.8%, and the minimum - 88.3 ± study included 15 patients who had a 4.9%; averages of PetCO2 – 39.6 ± clear medical history and clinical 2.6 mm Hg, and maximum - 43.2 ± signs of OSA without obvious 1.6 mm Hg; average number of oRDI mechanical impediment in breathing – 4.7 ± 0.3 / h. and max- 5.3 ± 0.2 / h through the natural breathing .; maximum heart rate was 87.8 ± airways. During the "diagnostic" and 3.2 beats / min., and the minimum – "therapeutic" nights the indicator of 54.5 ± 3.2 beats / min. The obtained blood saturation (SpO2,%), carbon data show an adequate treatment of dioxide in the final portion of the OSA with the use of noninvasive exhaled air (PetCO2, mm Hg), the mask OSA -therapy and full number of obstructive events per normalization of oxygen status and hour (oRDI), and minimum and respiratory function. maximum heart rate (HR) were Conclusions. Obstructive sleep monitored with the use of "Somno apnea rapidly destabilizes the Chek" (Weinmann, Germany) oxygen status of the body and the The obtained results. It was alveolar ventilation. Adequately established that during the adjusted CPAP-therapy eliminates "diagnostic" night averages of life-threatening respiratory SpO2,in breathing with an disorders and minimizes the atmospheric air (FiO2 = 0,21) were cardiovascular and respiratory risks to 87.5 ± 4.6%, and the minimum and the fragmentation of a nocturnal 47.8 ± 3.1%; averages of PetCO2 – sleep.

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ISIC-2016 Abstract book Dziuba V., Bursak A. BURNOUT SYNDROME AND ITS CONNECTION WITH HIGH BLOOD PRESSURE Research advisor: Safargalina-Kornilova N.A., Assistant professor Department of Fundamentals of Internal Medicine N1, Fundamentals of Bioethics and Biosafety, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Relevance. Intensive social, The object of research. The economic and cultural development syndrome of burnout and its of modern society greatly increases connection with high blood pressure. the requirements for students. This Materials and methods. group of people faced with the need Anonymous survey of 200 students to control emotional states that of 3 course by questionnaire of cause the problem of finding the Boyko, questions to determine the most effective ways of emotional level of professional self- regulation and self-regulation of determination and achievement and students in stressful situations. blood pressure monitoring, Emotional "burnout" has a negative statistical data processing. influence on student health, which Results of research. Analysis of may lead to serious consequences in the results showed that the major the future. Therefore, the study of symptoms, determining the emotional burnout, features of development of burnout among manifestations of this syndrome, its students are improper emotional symptoms and clarify the factors that response (66,2%), reduction of lead to its formation becomes professional duties (44,5%), anxiety relevant. and depression (35%), experiencing Students with emotional stressful circumstances (39,4%). In burnout may develop high blood resistance phase is 42,3% of pressure. Its origin is connected with interviewed students, in the voltage the violation of the regulation of phase 15,4%, in exhaustion phase cortical and subcortical vasomotor 27,8%, no signs of burnout and system and hormonal mechanisms of stress showed 14,5% of students. blood pressure control. The reason Analysis of the development of for all this is a strong stress psycho- burnout syndrome, depending on the emotional state of students. Long achievements showed a high level of periods of high blood pressure lead burnout among the excellent to violations of hemodynamics, students (resistance phase 45,3% which can lead to strokes, heart and exhaustion phase 25,6%)and attacks. among students, who receives bad grades (46,3% and 42%) compared

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ISIC-2016 Abstract book to students, who studies well (34,6% emotional state, which subsequently and 20%). Analysis of blood pressure leads to burnout. One of the monitoring results showed that manifestations of this syndrome is excellent students, and those, who high blood preassure, the get bad grades have increased blood appearance of which is associated pressure. Students who are in the with the violation of the regulation of phase of voltage and resistance cortical and subcortical vasomotor phase have high blood pressure. system and hormonal mechanisms of Conclusions. Students are blood pressure control. exposed to stressful psycho-

Fomina L.V. CELLULAR AND HUMORAL IMMUMITY IN PATIENTS WITH ECZEMA Research advisor: Dashchuk A. M., professor Department of Dermatology, Venerology and AIDS, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Proved the role of (laboratory, allergic tests, immunological disorders in the immunogram) methods. All patients levels of initial pathogenesis of will receive basic treatment, eczema. This is manifested primarily according to the standard treatment cell of eczema, hyposensitization immunocompromised for T-system therapy, antihistamines, sedatives, of immunity. glucocorticosteroid drugs, vasoactive The aim. Improved treatment drugs immunocorrectors. of patients with eczema allowing for Results. To assess the state level the cellular and humoral immunity. cell immune response in microbial Materials and methods It is eczema was investigated in planned to survey 50 patients with peripheral blood content of the total different forms of eczema, while will T lymphocytes (CD3), T helper be a comprehensive clinical (CD4), -supresoriv (CD8), B - examination on the basis of lymphocytes (CD 19) in 30 patients complaints (skin lesions, swelling, suffering from the disease, and 15 itching), data history (history of the healthy donors. The average content disease, family history, detection of of CD3 -lymfotsytiv blood donors genetic predisposition), genetic and was 42,2 ± 0,2%, CD4 - 39,2 ± 1,86%, constitutional characteristics of the CD8 - 29,0 ± 0,87%. patient: ob` subjective (inspection, Conclusion. The practical palpation) and additional significance of the research is 343

ISIC-2016 Abstract book grounded in scientific efficacy of immunomodulators normalizing adjuvant therapy for eczema using effect on cellular and humoral immunomodulators. This therapy immunity. The use of helps accelerate the regression of immunomodulators can to prevent a clinical manifestations of disease due recurrence of eczema.

Kadykova O., Sheikh Saher THE RELATIONSHIP BETWEEN ANTHROPOMETRIC AND LIPID PARAMETERS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND OBESITY DEPENDING ON THE GENOTYPE GENE POLYMORPHISM OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (Glu298Asp) Research advisor: Kravchun P.G., Doctor of Medical Sciences, Professor Department of internal medicine № 2, clinical immunology and allergology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. A variety of studies studies were performed by the have suggested that the standard method for H. Feigenbaum polymorphism in the endothelial ultrasound devices RADMIR. The nitric oxide synthase was associated statistical processing of results was with ischemic heart disease. performed with the help of software Aim. The purpose of research package «Statistika» (StaSoftInc, – to examine the state of lipid USA). metabolism and constitutional Results. We have not been parameters in patients with ischemic established relationship between heart disease and obesity, depending volume of neck waist, hips, levels of on the genotype polymorphism of total cholesterol, triglycerides, low endothelial nitric oxide synthase density lipoprotein cholesterol, high (Glu298Asp). and very low density cholesterol and Matherials and genotype polymorphism of the gene methods. There have been a eNOS (Glu298Asp) in patients with comprehensive survey 222 patients ischemic heart disease and obesity. with ischemic heart disease. Conclusions. We have not Comparison group consisted of 115 been established relationship patients with ischemic heart disease between anthropometric parameters with normal body weight. The and genotype polymorphism of the control group included 35 healthy gene eNOS (Glu298Asp) in patients individuals. All patients underwent with ischemic heart disease and general clinical and instrumental obesity and not found associations examination. Echocardiographic with metabolic lipids. 344

ISIC-2016 Abstract book Kaluzhka V., Markevych M. HORMONAL AND METABOLIC DISORDERS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES Research advisor: Zhuravlyova L. Department of Internal Medicine №3 Kharkiv National Medical University Kharkiv, Ukraine

Actuality. The basis of the parameters (ALT, AST) and index pathogenesis of nonalcoholic fatty HOMA-IR. liver disease (NAFLD) is Results. Changes of BMI were insulinresistance (IR), which appears noticed in 94,5% of patients: 54,6% in the background of abdominal had 1st degree of obesity, 31,4% - obesity (AO), which in turn is a key 2nd degree obesity and 4,6% factor in the origin of an imbalance suffered from 3d degree of obesity. between adipocytokines that entail Level of AN was decreased disturbances of lipid and comparing to the control (8,7±2,4 carbohydrate metabolism, which ng/ml vs 15,4±2,1 ng/ml, р<0,05) ultimately leads to damage of liver and correlated with the degree of cells, development of inflammation, obesity - 6,5±2,1 ng/ml in patient wit fibrosis and apoptosis. 3d degree obesity (р<0,05). Negative The aim was to study the correlation relashionships were peculiarities of changes of determined between the levels of AN adiponectin (AN) level depending on and BMI (r=-0,36; р<0,01), WC (r=- the functional liver parameters and 0,34; р<0,05). The level of AN was index of IR in patients with NAFLD authentically getting lower as the and diabetes mellitus (DM) type 2 level of ALT (r=-0,44; р <0,001) and and AO. AST (r=-0,46; р<0,001) became Materials and Methods. 25 higher. The negative correlation is patients (10 men and 15 women) found between the level of AN and with NAFLD and DM type 2 (HbA1c index HOMA-IR (r=-0,46; р<0,001). <7,5%) were examined. Control Conclusions. group consisted of 12 almost healthy Hypoadiponectinemia in patients persons. Clinical investigation with NAFLD and DM type 2 is included estimation of associated with AO, worsening of antropometric parameters (body functional liver parameters and mass index (BMI) and waist progression of IR, which leads to circumference (WC)), functional liver continuous formation of metabolic disorders in liver.

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ISIC-2016 Abstract book Kashtan Kateryna THE STUDY OF PHYSICAL ACTIVITY OF CHILDREN WITH TYPE 1 DIABETES USING QUESTIONNAIRE Research advisor: Assistant Morozov Oleksandr Department of Physiological Pathology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Currently, the Children and Adolescents (PAQ-C question of the development of safe and PAQ-A). Physical activity was and reliable methods for assessing assessed for 7 days. By PA level the level of physical activity (PA) of patients were divided into age children is topical. As the gold groups: 1 group – 7-10 years (n = 7), standard an accelerometer is often 2 group – 11-14 years old (n = 12), used. Due to the high cost and group 3 – 15-18 years (n = 6). difficulty in applying some groups of Statistical analysis was performed patients (children, emotional and using Excel applications. hyperactive patients) it isn't always Results. It was found that with possible to use it. One of a simple and increasing duration of the effective indicator of PA assessment substantial difference in the level of is a method of questioning. It has a the disease were observed PA number of advantages over an (fluctuations ranged from (3,38 ± accelerometer, such as fast data 1,06) points) to ((4,0 ± 0,3) points). acquisition, efficiency, convenience Thus the tendency to decrease with and low cost. increasing level of PA age ((3,2 ± 0,6) Aim of our study, the points) in comparison to the children assessment of physical activity of groups 1 and 2 ((4,0 ± 0,3) points) children with type 1 diabetes, using and ((4,2 ± 0,5) points). It is questionnaire. accompanied by a deterioration of Materials and methods. metabolic control in adolescents During the performance examination (HbA1 (10,3 ± 0,3)%) compared with of 25 children aged 7-18 years with children of group 1 (HbA1 (8,0 ± various duration of type 1 diabetes. 0,7)%). In group 2 in children aged It was conducted to determine the 10-14 years the level of level of compensation of compensation of carbohydrate carbohydrate metabolism (glycated metabolism was unsatisfactory hemoglobin – HbA1c) and also (HbA1 (11,3 ± 0,1)%), although it conducting the questionnaire and was not accompanied by a decrease identification of patients PA level in PA. with using questionary The Physical Conclusions. Thus, children Activity Questionnaire for Older with type 1 diabetes there is a

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ISIC-2016 Abstract book decrease of PA with age, which is teenagers of 15-18 years, but not in accompanied by an insufficient the early pubertal age. compensation of disease among

Kopanska Dzw., Borachok T. ESOPHAGITIS: REALITY TODAY, PRACTICE PATTERNS AND RESULTS Research advisor: Yatskevych O., PhD, Associate Professor Therapy department Lviv National Medical University, Lviv, Ukraine

Actuality. Gastroesophageal reflux study. Laboratory and pathology disease (GERD) is a chronic disease data were reviewed for initial and which causes esophagitis, Barrett’s follow up endoscopy. Demographics, esophagus (BE) and esophageal severity of esophagitis, length of BE, cancer. Esophagitis is one of the most follow-up recommendations, and prevalent diseases in the Ukraine outcomes were recorded. ,with up to 16% of the adult Results. Of the 96 patients population affected by daily involved in the study, 7 had symptoms. suspected BE on EGD. Among those The aim. Our objectives were to patients with suspected BE, 4 had a understand the practice patterns in follow up EGD, none of which the management of patients with showed severe esophagitis. Although esophagitis, characterize patients 23 of the 96 patients (23%) had with esophagitis who presented to esophageal biopsies, only 2 had Lviv Regional Hospital (LRH) for tissue pathology confirming Barrett’s endoscopy, and to evaluate short- esophagus. term outcomes in these patients. Conclusion. Our data Materials and methods. We demonstrates, among other findings, identified patients with an that we are not optimizing acid endoscopic diagnosis of esophagitis, suppression use in disease processes who presented to LRH for upper that are acid mediated. More endoscopy for any indication research and development of between February 5st and October standardized protocols to guide care 28st 2015. After exclusion criteria for patients with esophagitis and were considered a total of 96 help decrease endoscopy costs are patients were identified for the warranted.

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ISIC-2016 Abstract book Koteliukh M.Y., Martovytskyi D.V. THE STUDY OF DYNAMICS OF MATRIX METALLOPROTEINASE-13 AND TENASCIN C IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND TYPE 2 DIABETES Research advisor: Kravchun P.G., doctor of medicine, professor Department of internal medicine № 2, clinical immunology and allergology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Today, the (Immuno-Biological Laboratories Co. cardiovascular diseases are the Ltd. (IBL), Takasaki-Shi, Japan). actual problem worldwide. It is Results. The level of MMP-13 known that matrix for 1-2 days in patients with AMI and metalloproteinases (MMP) and type 2 DM was 65,6 ± 2,5 pg/ml and tenascin C are considered as 47,9 ± 3,8 pg/ml without type 2 DM prognostic markers of the heart compared with the control group - diseases. 32 2 ± 2,6 pg/ml (p˂0,05). The level Aim. Study the role of matrix of Tn C for 1-2 days in patients with metalloproteinase-13 and tenascin C AMI and type 2 DM was 18,64 ± 1,28 in patients with acute myocardial ng/ml and 20.12 ± 1,48 ng/ml infarction and type 2 diabetes. compared to the control group - Matherials and 14,93 ± 0,97 ng/ ml (p˂0,05). The methods. In the study were content of MMP-13 for 10-14 days examined 120 patients, which significantly increased in patients obtained the treatment in Kharkiv with AMI and type 2 DM by 17% clinical hospital № 27. All patients compared with patients with AMI were distributed into groups: basic without type 2 DM (p=0.0316). group consisted of 60 patients with Discovered reduce Tn C in patients acute myocardial infarction (AMI) with AMI and type 2 DM by 39% with concomitant type 2 diabetes (p=0.0001) compared with patients mellitus (DM); the comparison group with AMI without type 2 diabetes. - 40 patients with AMI absence of Conclusions. Hence, in type 2 diabetes; control group - 20 patients with acute myocardial people. The matrix infarction and type 2 diabetes more metalloproteinase-13 (MMP-13) was likely determined by determined by ELISA using set of hyperproduction MMP-13 compared reagent «Human MMP-13» with AMI patients without type 2 (RayBiotech, Norcross, USA); diabetes, which may be due to the tenascin C (Tn C) - «Human effects of hyperglycemia. The Tenascin-C Large (FNIII-C)» decrease in dynamic content tenascin C in patients with acute

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ISIC-2016 Abstract book myocardial infarction in the presence disbalance in the system of type 2 diabetes indicates on the extracellular matrix.

Kotvitskaya Valeria ENDOTHELIAL DYSFUNCTION BIOMARKERS IN OBESE PATIENTS WITH ARTERIAL HYPERTENSION Research advisor: candidate of medical sciences Demydenko Ganna Department of Fundamentals of Internal Medicine #1, Fundamentals of Bioethics and Biosafety Kharkiv National Medical University Kharkiv, Ukraine

Actuality: obesity is strongly Spirmen's correlation coefficient was associated with arterial hypertension used to compare pairs of variable and cardiovascular disease. and p<0.05 was regarded as Endothelial dysfunction in obese significant. 5-10 mg nebivolol patients plays a pivotal role in the treatment was provided during 6 development of hypertension. weeks. Aim: estimation of endothelial Results: body mass index - dysfunction on the basis of 31,33±4,10 kg/m2,in control - endothelial and inducible synthases 23,08±1,53 kg/m2. Systolic arterial activity and nebivolol’s impact on the pressure (SAP) - 171,4±10,3, endothelial function in obese diastolic (DAP) - 101,7±8,5 мм. рт. patients with arterial hypertension. ст.before treatment. SAP and DAP Materials and methods: 25 after treatment - 135±6,1 and previously untreated hypertensive 88,3±6,9 respectively. NO2 was patients (males/females 7/8; mean changed from 12,11±6,21 till age 52.6±0.95 years) were enrolled 14,21±2,42 mcmole/l. NO3 increased in this study. We excluded patients after treatment from 19,12±6,74 till with heart failure III NYHA 22,67±3,21 mcmole/l, . p<0,05/ functional class, and with lungs, liver As it shown 5-10 mg nebivolol and/or kidney disorders, which therapy improve endothelial influenced nitric oxide production. function by increasing of e-NOS Plasma Nitric oxide synthases (eNOS, activity from 0,731±0,113 till iNOS) levels were examined by 0,762±0,069 pcmole/min*mg biochemical method. S-nitrozotiol protein, decreasing of iNOS from level was measured by biochemical 0,589±0,116 till 0,232±0,108 method as oxidative stress marker. pcmole/min*mg protein and as Differences between the groups were antioxidant action promote declining calculated by Student's t-test. of S-nitrosotiol levels 0,45±0,19 till 349

ISIC-2016 Abstract book 0,33±0,16 mmole/l as markers suggest that nebivolol improves ofoxidative stress. endothelial function in obese Conclusion: e-NOS and i-NOS hypertensive patients by stimulating levels could be used as biomarkers of nitric oxide synthesis and its endothelial dysfunction and also antioxidant ability, can be could be used as treatment recommended for long duration effectiveness markers. The results treatment as monotherapy.

O. P. Kozlov, S. G. Malanchuk, O. G. Sorokina, A. O. Radchenko IMPACT OF VIOLET, GREEN AND ORANGE SPECTRA LED RADIATION ON LECITHINASE AND DNASE ACTIVITY OF S. AUREUS AND E. COLI V. N. Karazin Kharkiv National University (Department of General and Clinical Immunology and Allergology)

Relevance. S. aureus and E. Institute of Epidemiology and coli are the most common types of Infectious Diseases of NAMS of gram-positive and gram-negative Ukraine, and clinical strains removed bacteria, respectively, which cause from peripheral venous catheter, inflammatory processes. An drainage structures, catheters and extracellular enzyme system of the from clinical material from infected bacteria that inhibit macroorganism children with inflammatory protective factors or increase the processes that were in Public aggressiveness of the microorganism Healthcare Institution "Kharkiv play an important role in the Regional Children Clinical Hospital development of these conditions. № 1"; electromagnetic radiation in These enzymes are lecithinase and the orange (590 - 600 nm), green DNase. Today, the question of (490-570 nm) and violet (380 - 430 theoretical and experimental nm) spectra optical range. We used justification of the interaction bacteriological methods. mechanism of LED radiation with Determination of DNase activity was enzyme activity is rather relevant carried by Jeffries CD method. In and insufficiently studied. order to determine lecithinase Aim. to estimate the impact of activity agar Hotynhera followed by violet, green and orange spectra LED measuring the diameter of the radiation on enzyme activity of S. corolla around the colony was used. aureus and E. coli. Results. When studying the Materials and methods of the enzymatic profile of strains it was research. Subject of the study were found that the lecithinase and DNase the reference microorganisms activity output after exposure to strains of S. aureus, E. coli, obtained violet spectrum LED radiation tends from the L. V. Gromashevsky to decrease at 600 and at 1800, 350

ISIC-2016 Abstract book moreover high level of activity was respectively). After exposure to the not recorded during the day in any orange spectrum LED radiation strain compared with controls: at 600 clinical S. aureus strains possessed were inactive by the ability to high DNase (from 47.6% to 100%) produce enzymes DNase and and lecithinase (from 52.4% to lecithinase 85.7% of S. aureus strains 100%) activity during the day, all S. and 80.9% of E. coli strains, at 1800 - aureus strains had high lecithinase 90.4% of S. aureus strains, 85.7% of activity at 1200 and at 2100, high E. coli strains. In S. aureus were DNase activity of E. coli strains was found high photoacceptor properties observed at 1200 (80.9%) and at 2100 to green spectrum, which may be (100%). It is worth to note that at associated with the formation of 1800 clinical S. aureus strains had no pigment by S. aureus. At 1200 average high DNase activity. activity of all S. aureus strains and Conclusion. Thus, violet, green 47.6% of E. coli isolates were and orange spectra LED radiation observed under the influence of the was characterized by changes in the green spectrum LED radiation, at enzyme profile of S. aureus and E. 2100 - 95.2% of S. aureus strains and coli cultures, that was not only 57.1% of E. coli isolates. At 600 and at different in comparison with each 1800 lecithinase activity of E. coli other, but also between the same strains tended to decrease (19.1% - strains according to circadian average active and 33.3% slightly biorhythms of microorganisms. It active and 47.6% - inactive was found that the impact of violet microorganisms strains and 19.1% - spectrum LED radiation contributed average active and 28.5% poorly most pronounced inhibition of active and 52.4% - inactive pathogenicity factors, especially such microorganisms strains enzymes as and DNase.

Kravchun P.P. THE LIPID AND CARBOHYDRATE PROFILE IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS, TYPE 2 DIABETES AND OBESITY IN 6 MONTHS AND 1 YEAR AFTER MYOCARDIAL REVASCULARIZATION Research advisor: Bilovol O.M., MD, Academic AMN of Ukraine Department of Clinical Pharmacology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Number of patients to year as in Ukraine also among with combined pathology - Europe population. postinfarction cardiosclerosis, type 2 Aim. To investigate the diabetes and obesity is increase year carbohydrate and lipid metabolism 351

ISIC-2016 Abstract book in patients with postinfarction postinfarction cardiosclerosis, type 2 cardiosclerosis, type 2 diabetes and diabetes and obesity obesity in 6 months and 1 year after Conclusions. In both groups, 6 myocardial revascularization. months and 1 year after Matherials and methods. revascularization significant There were examined 58 patients differences in carbohydrate and lipid who took thrombolytic therapy and metabolism in the examined 32 patients who underwent patients, depending on the type of percutaneous coronary intervention. reperfusion therapy have not been Results. Comparison of two established, that indicates, that a methods of revascularization at 6 comparative analysis of different months showed no preference to any modes of myocardial of them in patients with revascularization did not show any advantages of them.

Mayorova Margarita, Kovalyova Yulia, Shelest Boris SMOKING AS RISK FACTOR AT PATIENTS WITH THE COMBINED COURSE OF ARTERIAL HYPERTENSION AND DIABETES 2 TYPES Research advisor:Prof. Shelest Aleksey Kharkiv National Medical University Department of Internal Medicine No. 2, Clinical Immunology and Allergology

Actuality: Nowadays the been made by 24 men at the age of arterial hypertension (AH) and the 52 ± 8,2 years with a combined diabetes (D) 2 types take the big part course of D 2 type and AH which in structure of incidence of the don't smoke. Examination has been population. It is known that smoking conducted according to diagnostic causes endotelial dysfunction which standards. AH have been diagnosed leads to development of AH and D2 by manipulation measurement of type. arterial pressure, EHOEKG, The aim: To define smoking assessment of the central influence extent on the general links haemodynamics and geometry of the of pathogenesis of AH and D 2 type. left ventricle. For determination of Materials and methods: The the last two parameters the device examinated group have been made "HD11XE" (Philips, USA) have been by 27 smoking men at the age of 52 ± used. The diagnosis of D 2 type have 8,2 years with a combined course of been made by application of the D 2 type and AH. Control group have capillary blood analysis, definition of 352

ISIC-2016 Abstract book glycozed hemoglobin and test on revealed reliable increase of a tolerance to glucose. Existence of homocysteinum to 24,7±0,93 endotelial dysfunction was estimated (р<0,005) mmol/l and decrease of by definition of mediators of NO to 6,3 (р<0,005) mM/ml. At the endotelial damage: homocysteinum control group level of a and nitrogen oxide (NO). homocysteinum was increased to Results: Presence of smoking 19,6±0,93 (р<0,005) mmol/, and NO aggravates the a combined course of decreased to 6,6 (р<0,005) mM/ml. these pathologies. It is confirmed by Conclusions: It is shown the increase of EDV to 214,5±21,1ml and considerable influence of smoking to ESV to 178,25±11,12 ml in the deterioration of condition of examinated group and EDV endotelial dysfunction and to198,5±21,1мл, ESVto deterioration in a combined course 168,25±11,12 ml in control group. of D 2 type and AH. Besides, in examinated group it is

Medyanik E.A., Maslova E.S. ANALYSIS OF PROGNOSTIC FACTORS FOR EARLY MYOCARDIAL INFARCTION Research advisor: Safargalina-Kornilova N.A., CandMedSci, ass.prof. Department of Propaedeutic of Internal Medicine №1, Fundamentals of Bioethics and Biosafety Kharkiv National Medical University, Ukraine

Actuality. In Ukraine cases. Thus, early diagnosis of cardiovascular disease continues to myocardial infarction (MI) remains occupy a leading position in the an important issue today. ranking of the reasons for the high The aim. To analyze mortality rate. 35% cases of laboratory indicators to determine mortality due to acute myocardial the early signs (MI). infarction according to the Ministry Materials and methods. We of health of Ukraine for 2015. conducted a study that involved 22 Despite the fact that most patients patients (13 men and 9 women) aged seek professional help in the first from 52 to 67 years, on the basis of hours of acute coronary syndrome, a City clinical hospital №11 during number of difficulties is associated 2015-2016. These patients came in with the outside of the flow, the first hours of the disease with a asymptomatic of clinical disease or diagnosis of acute coronary absence of diagnostically significant syndrome. All patients were assigned ECG changes in 30% of diagnosis to a general blood analysis, and in 353

ISIC-2016 Abstract book the first 3, 6 and 12 hours there were hours AST was 69.2±7,1 IU/l, ALAT – determined for the level of enzymes 55,2±4,3 IU/l, 6 hours AST – activity: AST (aspartate 57,1±3,2 IU/l, ALAT – 81,5±1,9, 12 aminotransferase), ALAT (alanin hours – AST-105,4±9,1 IU/l, ALAT - aminotransferase). 60,3±1,5 IU/l. However, it should be Results. In 17 patients (77%) noted that only 18 patients (81%) there was observed had confirmed acute myocardial polymorphocellular leukocytosis infarction (the diagnosis was based (mean value - 35±3,3××〖10〗^9/l, on clinical, objective, laboratory which indicates nonspecific reactions datas). of an organism in response to Conclusions. Thus, myocardial damage. In 19 cases leukocytosis, neutrophilia with a (86%) we found the shift of pronounced left shift, leukocyte formula to the left, at the hyperfermentemia AST, ALAT were expense of band neutrophils. In 21 found in almost all patients in acute patients (95%) we noted an increase coronary syndrome, indicating a lack in the activity of enzymes. The of specificity of these indicators. average of indicates were the next: 3

Melenevych A. Ya. IMPLICATION OF INTERLEUKIN-18 IN THE PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH HYPERTENSION

Research advisor: Kapustnyk V.A., Doctor of Medical Science Department of internal and occupational diseases, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Chronic obstructive Materials and methods. A pulmonary disease (COPD) patients number of population studies have are at a high risk of developing shown that airflow limitation as cardiovascular diseases. Airflow measured by the forced expiratory limitation is a predictor of future volume in one second (FEV1) or the risks of hypertension and FEV1/forced vital capacity ratio is a cardiovascular events. predictor of future risks of Aim of the investigation was to hypertension and cardiovascular reveal the implication of Interleukin- events. The other review described 18 (IL-8) in the pathogenesis of that for every 10% decrease in FEV1, COPD in combination with all-cause mortality increases by 14%, hypertension. cardiovascular mortality increases by 28%, and nonfatal coronary 354

ISIC-2016 Abstract book events increase by almost 20% (Yuki activates the specific immunity. IL-18 Imaizumi, Kazuo Eguchi, Kazuomi induces the production of interferon- Kario, 2014). γ (IFN-γ) in T cells, macrophages, Results. COPD is characterized and NK cells and promotes by a low grade systemic differentiation of T cells, underlying inflammation, closely associated the development of proinflammatory with its extrapulmonary and proatherogenic immune determinations. The relation of response. inflammation with cardiovascular Several studies have shown that disease in patients with COPD is serum IL-18 levels have negatively complex. Circulating mediators, such correlated with FEV1 in COPD as cytokines and C-reactive protein patients. Overexpression of IL-18 are capable of inducing endothelial and IFN-γ-inducing factor lead to dysfunction that initiates and then severe emphysematous changes and contribute to the progression of chronic inflammatory changes atherosclerosis. The activation of characteristic of COPD. endothelium results in increase Conclusion. Future studies of endothelial permeability with uptake the role and mechanism of of oxidized low-density lipoprotein participation of IL-18 and other into the atherosclerotic plaque cytokines in the formation of COPD which leads to rupture and thrombus in combination with hypertension formation with the development of will open new opportunities for heart attacks and strokes. effective targeted methods of early IL-18 belongs to the interleukin-1 prevention and treatment of cytokine family, is characterized by comorbid pathology. proinflammatory activity, and

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ISIC-2016 Abstract book Melenevych A. Ya. DIAGNOSTIC AND PROGNOSTIC ROLE OF MARKERS OF IMMUNE INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH HYPERTENSION

Research advisor: Kapustnyk V.A., Doctor of Medical Science Department of internal and occupational diseases, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Currently 210 the production of several pro- million people have chronic inflammatory cytokines that increase obstructive pulmonary disease in serum and in secretions of CVD (COPD) and it is predicted to become and COPD patients. Сytokines play a the third leading cause of death key role in orchestrating chronic worldwide by 2030. In 2008, inflammation, and over 50 cytokines worldwide, approximately 40% of have now been identified in COPD, adults aged 25 and above had been but their roles in its complex diagnosed with hypertension. pathophysiology are still unclear. Materials and methods We Cytokines work in complex have analyzed the most significant interacting networks, and there is factors associated with increased often redundancy in their functions cardiovascular risk in patients with (Barnes P.J., 2009). COPD. Clinical and epidemiological Hypertension is related to the observations indicate that COPD increased systemic inflammation patients are more susceptible to observed in COPD and is correlated acute cardiovascular events, and with higher Medical Research about 30% die of CVD (Corbi G., Council dyspnea scores, reduced Bianco A., Turchiarelli V. et al., 2013). capacity for physical activity and Some of this increase in risk is likely airflow obstruction (Hillas G., to come from shared factors, such as Perlikos F., Tsiligianni I. et al., 2015). smoking, elderly age, decrease in Conclusion. The physical activity, but chronic interrelationships between different systemic inflammation could be cytokines are currently very poorly pivotal. understood. Future prospective Results. Systemic inflammation studies should investigate if these is potentially the common pathway markers will give important leading to the high prevalence of prognostic information in relation to multiple chronic diseases in the same disease progression and severity in patient. The chronicity of the COPD. inflammatory state is promoted by

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ISIC-2016 Abstract book Mieshchanina D.R. THE THERAPY OF CIRCULATORY FAILURE IN PATIENTS WITH CHRONIC PULMONARY HEART DISEASE Kharkiv National Medical University (Department of Internal and Occupational Diseases, Ukraine, Kharkiv) Scientific leaders: Ph. D., associate professor Pogorelov V. M., Ph. D., professor Telegina N. D., Ph. D., Ph. D., assistant Maslova E. P., associate professor Brek V. V,

Recently observed increase in clinical and functional form of the chronic obstructive pulmonary disease. There was clinical and disease (COPD). From 4 to 10% of laboratory identity of patients. the adult population of the planet are State of intracardiac symptomatic stages of COPD. In hemodynamics assessed by Ukraine, about 7% of the working echocardiography, mean pulmonary population suffer from this disease. artery pressure (STLA) - using COPD is characterized by doplerEhoKH. Condition blood gas progressive airflow obstruction, and composition was evaluated in terms exacerbation of the pathological of rCO2 and rO2 in arterial blood. process leads to changes in the The results of research on normal daily variability of symptoms the background of the therapy in with increased average pressure in patients with second observation the pulmonary artery (STLA) which group compared with patients from results in chronic lung heart (CLH). first group noted a significant Purpose - optimization of improvement in the general treatment failure in patients CLH. condition of patients: decreased of Materials and methods for dyspnea , weakness, malaise. On therapeutic department DKL st. palpation determined the reduction Kharkiv in the 2013-2015 biennium. in size of liver and almost Under observation were 59 patients disappeared edema of the lower with B-NKIIA against the backdrop of extremities, accompanied by CLH. The average age of patients was improving the transfer of physical 66 ± 5 years. All patients received activity. general therapy. Group 1 (20 people) Conclusions. The use of additionally included telmisartan 80 telmisartan combined with mg / day (group). Patients from furosemidom® in the treatment of second group (39 people) - patients CLH, accompanied by torasemid® telmisartan + 20 mg / improvements in intracardiac day (study group). Both groups of hemodynamics and reduced clinical patients were compared CLH as age, manifestations of heart failure.

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ISIC-2016 Abstract book Therapy failure in patients CLH exchange of sodium and potassium, telmisartan and its combination with giving rise to more widespread use torasemidom® clinically of this combination therapy in accompanied by signs of ion patients CLH.

Mykhailiuk Natalia Valeriivna APPLYING OF CARDIAC SHOCK-WAVE THERAPY IN THE PATIENTS WITH A STABLE ANGINA PECTORIS II-III FC dept. of Internal Medicine № 1 with course of cardiovascular diseases Odessa National Medical University Odessa, UKR

Importance. An increasing part. The first group are treated with number of patients are diagnosed medicines and with a course of SWT. with the stable form of angina The second one (group of control) pectoris.Such procedures as are treated only with medicines. coronary bypass grafting ( CABG ) or Results. Significant percutaneous coronary intervention improvement in chest pain can’t be applied to all patients. symptoms, use of nitrates decreased Nowadays a new way of treatment is from about 8 to 3 tablets per week. being developed - therapeutic Ejection of left ventricular has been angiogenesis , which is achieved by increased through 6 month from the shock-wave therapy ( SWT ). beginning of course from 31 +-4 % Goal. To learn the influence of to 36 + -5%. An increasing of quality CSWT on the patients with angina of life according to special pectoris II-III FC. questionnaires has been followed. To learn the influence of CSWT on There was a reduction of functional duration and of frequency of attacks. class of angina pectoris from 2.4 to To learn the influence on 1.5. The indicators of veloergometry contractility and ejection fraction of is increased on 27%. left ventricular. To look at the Conclusions. Extracorporeal dynamics of functional class of cardiac SW therapy is an effective, angina pectoris. And also to learn if safe and non- invasive therapeutic there are any changes of life’s quality option for severe angina pectoris II- according to the questionnaire “SF- III FC. This method of treatment 36” . helps to improve the quality of life, to Methods and Materials. In decrease the number of chest pain this research two groups of patients attacks and also to prevent the with angina pectoris II-III FC take progression of heart weakness.

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ISIC-2016 Abstract book Minukhina D.V., Gabisoniya T.N, Shapirko E.A. PATHOGENETIC VALUE OF VISFATIN AND ADIPONECTIN IN PATIENTS WITH STABLE ANGINA AND OBESITY Research advisor: Kravchun P.P., MD, Doctor of Medical Sciences Department of internal medicine №2, clinical immunology and allergology Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Coronary heart Results. The study of the disease (CHD) is the leading health dynamics of exchange adipokinovogo problem in many countries. One of visfatin level reached 30,1 ± 1,2 ng / the most common forms of ischemic l, and adiponectin decreased to 5,17 heart disease is stable angina. ± 0,15 ng / l , indicating that Comorbidity of stable angina and hipoadyponektynemiya and obesity is the trigger mechanism of hipervisfatynemiya associated with the pathophysiological cascade the development of obesity in development and progression of patients with stable angina. Given atherosclerosis. the above, it can be assumed that Aim. To optimize the adypokinʼ s dysfunction exchange diagnosis and treatment of against the backdrop of increased cardiometabolic disorders on the body weight contributes to the basis of clarifying the pathogenetic development and progression of role of adipocytokines -visfatina and atherosclerosis in patients with adiponectin in the development of stable angina by exhaustion atherosclerosis in patients with antiatherogenic opportunities of stable angina and obesity. adiponectin and activation metabolic Matherials and methods. 60 disorders by visfatyn. patients with stable angina. All the Conclusions. Thus, the study patients were divided into 2 groups: of pathogenic importance visfatin patients with stable angina with and adiponectin in patients with concomitant obesity (n = 35) and stable angina and obesity can be patients with stable angina without used as a predictor of the obesity (n = 25). The control group development and progression of consisted of 10 healthy individuals. stable angina.

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ISIC-2016 Abstract book Molotyagin Dmitry, Mironchenko Anastasia, Sukhomlyn Mykola CLINICO-EPIDEMIOLOGICAL AND DIAGNOSTICAL ASPECTS OF THE OLLIER DISEASE Research advisor: profesor, doctor of medical science Kravchun Pavlo Grigorievich The department of internal medicine №2 and clinical immunology and allergology Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Ollier's disease (OD) Diagnostics of OD is still considered (chondralloplasia, dyschondroplasia) to be very difficult for a wide range – systemic skeletal disease of doctors, due to the absence of characterized by a slow and specific lab-instrumental tests, perverted ossification of cartilage. insufficient knowledge of clinical The epidemiology of this disease was signs, diagnostic criteria and hardly studied due to its relative existence of atypical forms of the rarity. disease. Often, patients are exposed The aim of this research was erroneous diagnosis of osteomyelitis, to analyze the existing data by using rheumatoid diseases, tuberculosis scientometric databases. and tumors. Consequently, patients Result: Despite the fact that a are given specific treatment that significant number of studies increases the severity of the disease. devoted to this disease had been published all over the world, there In most cases, OD is characterized by are only a few descriptions of the unilateral damage of ossa, shortening disease in Ukraine, but even they do and thickening of the affected limb, not always reflect the overall picture changed manner of walking, of the disease. There is a common claudication, and often secondary belief that the disease is inherented asymmetry of pelvis and spinal in childhood. Thus, all the scoliosis. However, bilateral form of diagnostics and treatment issues are the disease was described too, that considered only for this age group of causes multiple asymmetrical bone patients. However, a few cases of disorder. Pain syndrome is chondralloplasia among adults aged considered to be the leading sign in 16 to 60 years are known. OD is the OD diagnostics, as well as the considered to be a rare disease, but presence of tumor-like mass in the data sources indicate that there was epiphysial cartilage area of tubular an increase in the incidence rate all bones. Restraint of movement within over the world. This pathology the large joints was observed in occurs almost equally among men some cases. and women. Complexity of diagnosing the disease

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ISIC-2016 Abstract book is given a special emphasis by the Conclusions: Clear researchers, which includes complex understanding of OD epidemiology, diagnostic search using computed nature of the disease for different tomography, magnetic resonance age groups, possibility of atypical tomography, scintigraphy and bone- cases and diagnostic criteria will biopsy in addition to the standard facilitate just-in-time diagnosis of the diagnostic methods. disease and appropriate treatment.

Movchan Y.O., Yakymenko D.S DISORDERS OF LIPID METABOLISM IN PATIENTS WITH TYPE 2 DIABETES AND HYPOTHYROIDISM, CORRECTION OF THESE DISORDERS Research advisor: Docent Lakhno Olga Viktorivna Department of Internal Medicine №3 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Disorders of lipid without disturbance of thyroid metabolism, along with chronic function, the average age of patients hyperglycemia and hypertension can was 56,4 ± 1,1 years. In both groups lead to macrovascular and patients received metformin and microvascular complications in sulfonylurea drugs as hypoglycemic patients with type 2 diabetes therapy, lipid-lowering therapy has mellitus (T2DM). Patients with not been evaluated. Patients of the concomitant pathology, accompanied main group also received by a secondary dyslipidemia, that are replacement therapy with type 2 diabetes and hypothyroidism, levothyroxine, the average level of have a higher risk of these thyroid stimulating hormone (TSH) complications. was 7.5 ± 2 mkIE / ml. Аim of this study was to All patients underwent investigate the characteristics of determination of serum total dyslipidemia in patients with type 2 cholesterol, cholesterol levels of low diabetes and hypothyroidism, the density lipoprotein (LDL), correction of disturbances. cholesterol levels of very low density Material and methods: A total lipoproteins (VLDL), high density of 15 patients with T2DM and lipoprotein cholesterol (HDL) and moderate hypothyroidism (the triglycerides (TG). average age of patients was 55,6 ± Results: According to the 1,1 years) were classified into two study, high levels of triglycerides (5,2 groups . The control group consisted ± 1,2 mmol / l) prevailed in patients of 14 patients with type 2 diabetes of the main group, also increasing 362

ISIC-2016 Abstract book levels of VLDL (2,25 ± 0,3 mmol / L) there was a significant level decrease and LDL (4,02 ± 0 3 mmol / l) were of triglycerides to 2.2 ± 0.7 mmol / l, revealed. There was a direct p = 0.043, VLDL - 1.21 ± 0.2 mmol / l, correlation between the amount of p = 0.009, and LDL - 2,45 ± 0.2 mmol TSH and TG (r = 0,52, p = 0.03). / l, p = 0.0001. Preferential increase of VLDL (2,69 ± Conclusions: Dyslipidemia in 0,3 mmol / l) and TG (3,14 ± 0,3 patients with type 2 diabetes and mmol / l) was found in patients of hypothyroidism had a particular the control group. With the purpose features. It was characterized by an to correct dyslipidemia patients of increase of triglycerides, VLDL, LDL. the main group were assigned to a So for correction of the disturbances combination of atorvastatin 20 mg it is necessary to achieve euthyroid per day and fenofibrate 145 mg per status and to use the combination of day. At the same time, the correction lipid-lowering therapy - atorvastatin of doses of levothyroxine was and fenofibrate. examined. In 6 months of therapy

Onwujekwe Udodi E. MODERN ASPECTS OF TREATMENT OF RHEUMATOID ARTHRITIS Research advisor: Fedorov V. Department of Internal Medicine No.3 Kharkov National Medical University Kharkiv, Ukraine.

Actuality: Biological therapy Aim: To investigate the efficiency of rheumatoid arthritis involves the of tocilizumab in the treatment of use of certain groups of drugs which patients with rheumatoid arthritis. modify the activity of certain Materials and Method: 18 immune cells. These drugs include patients with rheumatoid arthritis, in groups such as inhibitors of TNF- the rheumatology department of alpha (infliximab, adalimumab), Kharkov Regional Hospital, were inhibitors of janus kinase started on treatment with (tofacitinib), inhibitors of IL-1 tocilizumab at a dose of 8mg/kg IV (anakira), inhibitors of IL-6 once a month for 4 months. The (tocilizumab), inhibitors of CD20 of patients were observed before B-lymphocytes (rituximab) and treatment, after two months and inhibitors of CD80, CD86 and CD28 after the 4months course of of T-lymphocytes (abatacept). treatment. Evaluation of the efficiency of treatment was carried 363

ISIC-2016 Abstract book out according to: visual analog scale, following side effects were observed: number of tender swollen joints, allergic rash on hands (5%), and flu- biochemical analysis and Xray like reactions (5%) - images. nasopharyngitis. Xray pictures Results: The most frequent showed decreased bony complaints of these patients were deformation. deformation of joints (100%), joint Conclusions: As a result of pain (100%), limitation of range of treatment of rheumatoid arthritis motion (100%), swelling of with tocilizumab, cessation of joint joints(72%), and morning stiffness destruction was observed, there was (89%). In all patients the number of decreased pain and swelling and the painful joints was decreased by patients’ quality of life was approximately 40-42%, the degree of improved. This group of drugs is joint swelling was decreased by very relevant in the treatment of about 57% on the average, rheumatoid arthritis. More research seromucoid levels dropped by about on biopreparations) should be made 9.7% and the level of sialic acid on a larger number of patients to decreased by about 3%. The observe other side effects if any.

Pochernina V. TOLL-LIKE RECEPTOS 4 AND 9 TYPES IN THE PATHOGENESIS OF PSORIASIS Research advisor: Dashchuk A. M., professor Department of Dermatology, Venereology and AIDS Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Psoriasis is one of the biopsies from areas of psoriatic skin most common chronic multifactorial rashes and skin intact in 25 patients disease. Psoriasis weight proportion with psoriasis. In addition to in the total skin diseases is from 7% comparing the results of to 10% and among hospitalized immunohistochemical studies patients with skin diseases to 20- carried out the study of biopsy 25%. material of skin of healthy people (5 The aim is to investigate patients). To determine the nature changes immunohistochemical and extent of local cellular immune expression of Toll-like receptor 4 and inflammatory reactions applied and 9 (TLR4, TLR9) in the skin of immunohistochemical techniques to psoriasis patients. determine the expression of markers Materials and methods. A of CD 284 (TLR4), CD289 (TLR9). immunohistochemical study of 364

ISIC-2016 Abstract book Results. The expression of TLR4 positive expression of the marker. and TLR9 in the epidermis of the TLR4- and TLR9-positive monocytes skin normally is most pronounced in and macrophages appeared in the the cells of the basal and spinous blood vessels and perivascular space layers. It should be noted that the of the papillary dermis. The greatest expression of nuclear receptors number of positive cells was mainly in the cytoplasm of epithelial observed in the vessels that were cells of the minimal coloration. In the placed in the nipples. epidermis intact skin of psoriasis Conclusion. Patients with patients determined more active psoriasis and found hypersecretion focal expression of TLR4 and TLR9. and hyperproduction of Topographically observed inflammatory skin epithelial predominant localization of these biomarkers, in particular TLR4- and receptors in the basal layer of the TLR9-positive cells, which appear epidermis. The skin of psoriatic both in the areas affected by plaques is determined by a psoriatic rash and the intact skin. significant thickening of the This indicates a permanent epidermis and the growth number of stimulation of macrophages and TLR4 and TLR9 positive cells. lymphocytes to sites not only Macrophages migrate in the vessels psoriatic plaques and in remote. of dermal papilla, had expressed a

Pylov D.I. THE EFFICIENCY OF COMBINATION THERAPY OF BIGUANIDES, STATINS AND ALPHA-LIPOIC ACID ON LIPID PROFILE IN PATIENTS WITH DIABETES TYPE 2 AND DIFFERENT PHENOTYPES Research advisor: Zhyravlova L.V., professor Department of Internal Medicine №3, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. It is well known, that The aim to valuate efficacy of diabetes mellitus (DM) type 2 is the combination therapy of associated with the development of biguanides, statins and alpha-lipoic obesity and insulinresistance, which acid patients with diabetes type 2 leads to dyslipidemia, and dyslipidemia with different atherosclerosis and cardiovascular phenotypes. diseases, decrease the number of Materials and methods Were fatal cases. exanimated 20 patients (5 men) with 365

ISIC-2016 Abstract book DM type 2, average age was 45.5±3.1 carbohydrate metabolism as: BCP duration of DM was 4.2±0.7, HbA1с 1.92 ± 0,43 mmol/l (from 10.8 ± 0.7 7,6±0,4, postprandial glycaemia mmol/l to 8.85 ± 0,3 mmol/l; p (PPG) 10,8±0,7. Body mass index ≤0.001), HbA1с from 7.6 ± 0.4% to (BMI) – 30,12±2.1 kg/m2, IR was 6,8 ± 0,2 % (p ≤0.001), the HOMA calculated by the formula HOMA = Index decreased from 5.5 ± 1.1 to 3,3 5,5±1,1. Total cholesterol (TC)– ± 0,4 (p < 0,001), BMI (30,12 ± 2.1 6,2±0,3.High density lipoproteins kg/m2 to 29.6 ± 1,31 kg)but p ≥ 0,05. (HDL) - 1,2±0,15.Low density Lipid metabolism: reduction in total lipoproteins cholesterol by 11% (from 6.2 ± 0.3 to (LDL)3,98±0,15.Triglycerides (TG) – 5,48 ± 0,2 mmol; p ≤ 0.05), LDL – 5.5 1,8±0,2.Dyslipidemia was based on % (3,98 ± 0,15 mmol/l to 3.7 ± 0.10 the determination (ТС, HDL, VLDL mmol/l), TG by 33% (from 1.8 ± 0.2 and TG) by colorimetric enzymatic mmol/l to 1.20 ± 0.18 mmol/l, p ≤ method. Treatment include diet, 0.05) The level of HDL changes were atorvastatin in daily dose of 10 mg, not reliable. Metformin in individually selected Conclusion. Combination dose, alpha-lipoic acid at dose of 600 therapy of biguanides, statins and mg number 10 i/v. alpha-lipoic acid leads to Results. Against the improvement of carbohydrate and background of 3-month therapy, it is lipid metabolism and also possible to notice clinical and contributes to the decrease of BMI in laboratory improvement of patients with diabetes type 2.

Pylova T.V., Dubivska S.S. THE RISK OF MYOCARDIAL INFARCTION AND ACUTE STROKE AMONG THE PATIENTS WITH A COMBINATION OF THE TYPE 2 OF DIABETES MELLITUS AND ARTERIAL HYPERTENSION Research advisor: Dubivska S.S., assistant professor Department of Critical Care Medicine, Anesthesiology and Intensive Care, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. There were 181300 increase the risk of cardiovascular patients of diabetes mellitus (DM) complications. registered in 2013 year in Ukraine The aim is to examine the risk (80 -90 % of them had DM type 2). of myocardial infarction (MI) and Among those patients, 70-80 % had stroke among the patients with hypertension. The combination of diabetes type 2, in combination with hypertension (HT) and DM type 2 hypertension. Early detection and 366

ISIC-2016 Abstract book prevention of the risk of MI and increasing of atrial systole time and stroke among the patients with HT compensatory hyperfunction of left and DM type 2. heart the patients of 1 group, as well Materials and methods. 105 as significantly increased levels of patients with DM type 2 in age of 40- lipid (TC-6.88 ± 0.21; HDL-1.02 ± 74 years were exam. Duration of DM 0.05; LDL-4.96 ± 0.25) and the type 2 was from 2 to 16 years. The 1 carbohydrate profile (FCG-11.1 ± 0.4, group included patients with DM PCG-14.22 ± 0.4, HbA1c-11.75 ± type 2 with HT (n = 65). The 2 group 0.31) in comparing with the 2 group, included patients with DM type 2 where such levels of lipid (TC-5.53 ± without HT (n = 40). The control 0.4; HDL-1.25 ± 0.07; LDL-3.53 ± group consisted of 10 healthy 0.31) and the carbohydrate profile human.Examination included (FCG-5.98 ± 0.24, PCG-8.19 ± 0.29, electrocardiogram (ECG), halter ECG, HbA1c-6.76 ± 0.4) were found. These blood pressure (BP) control, parameters in the control group echocardiography, lipid metabolism were normal. include total cholesterol (TC), high- Conclusion. Consequently, we density and low-density lipid (HDL), noted that among the patients with (LDL).Carbohydrate metabolism DM type 2 in combination with include glycemic profile: fasting hypertension the risk of capillary blood glucose (FCG); cardiovascular complications is postprandial blood glucose (PCG). significantly higher. Therefore, to Glycosylated hemoglobin (HbA1c) prevent the occurrence of such was used. complications as myocardial Results. It was found that infarction and stroke it is very among the patients 1 group level of important to care about early systolic BP and diastolic BP was detection and adequate treatment of above normal; the results of patients with type 2 of diabetes and echocardiography showed left hypertension. ventricular diastolic dysfunction,

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ISIC-2016 Abstract book Romanenko O.R., Talalaienko O.K. REPERFUSION ARRHYTHMIAS IN PATIENTS OF DIFFERENT AGE WITH ACUTE MYOCARDIAL INFARCTION Research advisor: Zhuravlyova L Department of internal diseases №3 Kharkiv national medical university Kharkiv, Ukraine

Actuality. Reperfusion injury is a was localized in anterior wall of LV phenomenon that occurs because of in 10 cases (52,6%) and in posterior restoration of normal blood flow in wall of LV in 9 cases (47,4%). ischemic region of myocardium and Results. In the first group develops due to calcium-mediated, arrhythmias in time of or just after oxygen-mediated and other stenting were registered in 11 pathways. In literature the incidence patients (52,4%). Reperfusion of reperfusion arrhythmias is: arrhythmias consisted of frequent accelerated ventricular rhythm - 80- polytopic premature beats in 7 cases 95%, ventricular premature (63,6%), hemodynamically complexes - 70-80%, ventricular significant bradycardia in 3 cases tachycardia - 65-80% and fibrillation (27,3%) and ventricular tachycardia - 6-10%. in 1 case (9,1%). In the second group Aim. To determine the incidence reperfusion arrhythmias occurred in of reperfusion arrhythmias in 7 patients (36,8%). It consisted of patients of different age and to frequent polytopic premature beats describe types of occurring rhythm in 3 cases (42,8%), ventricular disturbances. tachycardia in 2 cases (28,6%), Materials and methods. Case hemodynamically significant histories of 40 (40% were women) bradycardia in 1 patient (14,3 %) stented patients with diagnosis of and paroxysm of atrial fibrillation in acute myocardial infarction (AMI) 1 patient (14,3%). were analyzed. Patients were divided Conclusions. In both age groups into two groups by the age: the first reperfusion arrhythmias are group (n=21) – age under 60, frequent and dangerous average age 52,7±3,0 and the second complications of successful group (n=19) – age 60 and above, revascularization in patients with average age 67,7±3,0. In the first AMI. In patients under 60-years-old group the localization of AMI in as well as in patient 60-years-old and anterior wall of left ventricle (LV) above after restoration of blood flow was observed in 12 cases (57,1%) frequent polytopic premature beats, and in posterior wall of LV in 9 cases hemodynamically significant (42,9%). In the second group AMI bradycardia, ventricular tachycardia

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ISIC-2016 Abstract book have occurred. Paroxysm of atrial hemodynamically significant fibrillation occurred in 1 case in bradycardia were registered on group of older patients. In the first 20,8% and on 13% more often in the group reperfusion arrhythmias took younger group, respectively. In the place on 15,6% more often than in second group ventricular tachycardia the second group. Frequent polytopic occurred on 19,5% more often than premature beats and in the other group.

Rynchak P., Rostovtseva M. DAMAGE OF THE MYOCARDIUM IN PATIENTS WITH MITOCHONDRIAL DISEASES Research advisor: Kravchun P.G., doctor of medicine Department of internal medicine№2, clinical immunology and allergology, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Mitochondrial mitochondria. The analysis of many diseases result in damage of multicenter studies showed a more cardiovascular system including favorable course and prognosis of myocardium and the conducting mitochondrial cardiomyopathy system in approximately 25%, are during treatment with L-carnitine: progressive in nature. In some cases, died from cardiomyopathy – 20%, cardiomyopathy may be the first and live – 71%, heart transplantation - only manifestation of the disease. 9%. In the comparison group: died The aim is to study the pattern from cardiomyopathy – 11% died of myocardial damage in from other causes – 8%, live – 64%, mitochondrial diseases, methods of heart transplantation in 17%. medical treatment. Conclusion. It is important to Materials and methods. recognize the origin of mitochondrial Echocardiography, cardiomyopathy, cardiomyopathy, as it determines the analysis of published data. further tactics of patient's Results. The causes of many management. Additionally, the idiopathic and gestational including of L-carnitine in standard hypertrophic cardiomyopathies are therapy improves the course and mitochondrial diseases. It was found prognosis of the disease. L-carnitine that the cardiomyopathy in most is recommended in all forms of the cases is combined with a sharp cardiomyopathy. decline in the level of carnitine in the

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ISIC-2016 Abstract book Salawu K.T. THE EFFICIENCY OF DIFFERENT TREATMENT REGIMENS IN PATIENTS WITH PSORIASIS. Research advisor: Dashchuk A. M., professor Department of Dermatology, Venereology and AIDS, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. For years, doctors Results. Significant differences and dermatologists have been in recovery were observed between researching methods of treatment patients in groups 1 and 3 but only a for psoriasis, which is one of the slight difference between those in most common diseases of human groups 2 and 3. Clinically, patients skin that causes not only physical but who received combined therapy had also mental suffering. significant overall improvement. As a The aim is to determine the result of combined therapy, levels of rate of recovery in psoriasis patient ESR and Leukocytes which were receiving different treatment elevated at the start of therapy, regimens and their connection with significantly decreased. In groups 2 changes in levels of Immunoglobulin and 3, 53% of the patients had G (IgG). complete clinical recovery, and 32% Materials and methods. We with significant improvement. In examined 120 patients with group 1 35% of the patients had psoriasis (99 men & 21 women aged clinical recovery, 25% with 16-60 years). Patients were divided moderate improvement, 30% with into 3 groups. The 1st group (20 minor improvement, and 10% patients) received basic therapy- showed no response to the vitamin B6 1ml i/m 1x/day for treatment. Patients with psoriasis 20days & vitamin B12 500mcg i/m showed marked changes in immune 1x/day for 20days. The 2nd group status: suppression of T- & B-linked (20 patients) received-Dalargin immunity, activation of humoral 0.001 i/m 1x/day for 10days and immunity and excessive amounts of Amizon 250mg p/o 4x/day for circulating immune complexes in the 10days. The 3rd group (80 patients) blood. Reduced IgG levels after received combined therapy (basic treatment with combined therapy, therapy, Dalargin & Amizon). The was due to the reduction of their severity of the clinical manifestation secretion by reducing severity of was evaluated by the PASI-index & pathological process while elevated IgG levels & other immune markers levels of IgG after treatment with were closely monitored. basic therapy was due to the absence of mechanisms that contribute to

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ISIC-2016 Abstract book suppression of autoimmune in these components occurred in the reactions in psoriatic plaques. same direction, regardless of the Conclusion. In analysing the therapy. In our opinion, this is logical immunological parameters of because, in patients treated with patients with psoriasis, changes in Dalargin, Amizon and basic therapy dynamics of immune components was revealed improvement of the (CD4+, IgG) were revealed in skin process expressed in different patients of all 3 groups. Fluctuations degrees.

Semenovych O. B. HYPERTENTION IMPACT ON RENAL FUNCTIONING. REVIEW OF NOWADAYS PROBLEMS Research advisor – PhD., Professor Moyseyenko V.O. Department of propedeutics of internal medicine No 2, Bogomolets National Medical University, Kiev, Ukraine

Actuality. Kidneys - is one of hypertensive kidney damage can be the most important organs in the divided into three categories: 1) body, but at the same time they are systematic "load" by blood pressure; sensitive to adverse factors of 2) the degree at which the load is various origins. Therefore, kidneys transferred to the renal vascular bed; are one of the first organs who and 3) local tissue sensitivity to the respond and suffer injuries from desired degree of barotrauma. Along increased blood pressure. About 5% with classic mechanisms of kidney of all patients who suffer from damage development in arterial hypertension have kidney damage, hypertension, the recent but this figure is growing. acihevements in this problem study The aim. Identify pathogenetic have to be noticed. By the authors mechanisms and methods of [Trudu M. et al.2013] a new correction of renal disease for mechanism of kidney damage in patients with hypertension. arterial hypertension was Materials and methods. The demonstrated, it was found that study of the literature, its analysis for there is a genetic predisposition to determination of pathogenic hypertension and uromodulinis mechanisms and methods of expression level that promotes salt correction of renal disease for reabsorption in the kidney. During patients with hypertension. researches it was found that Results. According to the author pharmacological inhibition of sodium [Kurtz T. Et al.2003] factors of co-transporter - NKCC2 had a greater 371

ISIC-2016 Abstract book effect in lowering blood pressure for year. hypertensive patients who were Conclusions. It was established homozygous. In other studies that scale of damage to the kidneys [Murray D. Esler et al. 2012] it was and their operationing decrease proved that one of the pathogenic depends on the amount and duration mechanisms of renal dysfunction in of high blood pressure impact, arterial hypertension is increasing uromodulinis expression level and activation of renal sympathetic more. In-time diagnosis and system. It was found that renal correction helps to prevent the denervation provides sustained development of these disorders. blood pressure reduction up to 1

Shalkovskyi Y.I., Suchok S.O. SGLT2 INHIBITORS - A NEW NON-INSULIN APPROACH TO THE TREATMENT OF DIABETES MELLITUS TYPE 2 Research advisor – PhD. Doroshkevych I.O. Department of Clinical Pharmacy and Clinical Pharmacology, Vinnytsya National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Actuality. According to hypoglycemic drugs - SGLT2 statistical data of the International inhibitors. Diabetes Federation (IDF) in 2015 Materials and Methods. the number of DM patients was 415 Processing and analysis of million. By 2040, projected number publications in medical databases of patients will be about 642 million. Pub Med and Medscape. Despite the large arsenal of Results. SGLT2 inhibitors are a antidiabetic drugs, hypoglycemic group of oral hypoglycemic drugs means search with maximum which therapeutic target are kidneys. efficiency and minimal side effects The mechanism of action is glucose such as weight gain and and sodium symport blockage, which hypoglycemia level are continued. ensures reduction of glucose There is a need for new drugs with reabsorption and normalize non-insulin-dependent mechanism glycaemia. of action and efficiency which does Improved glycemic control under the not depend on the pancreas beta influence of SGLT2 inhibitors is also cells function. reduced glomerular hyperfiltration, The aim. The study of the which is a positive effect in regard to efficacy and safety of new class of the development of diabetic nephropathy. Glucose toxicity

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ISIC-2016 Abstract book reduction at the usage of these drugs effect which can lead to the is manifested in the recovery of the dehydration. Some researches pancreas beta cells sensitivity, thus highlight the risks of bone increasing insulin synthesis, and demineralization, cardiovascular sensitization of peripheral tissues to complications and ketoacidosis, insulin action. The usage of SGLT2 urinary bladder and breast cancer. inhibitors not only leads to blood Conclusions. This class of drugs glucose lowering but also to shift the offers a new non-insulin-dependent energy balance in a negative way mechanisms of glycaemia correction that creates additional benefits in in patients with DM type 2 at good diabetes patients with obesity. tolerability and absence of adverse Side effects of SGLT2 inhibitors effect on body weight, the risk of therapy include urinary tract hypoglycemia and other serious side infections, genital fungal infections. effects. These drugs also have a diuretic

O. P. Kozlov, S. G. Malanchuk, O. G. Sorokina, D. S. Mikhaylova THE RELATIONSHIP OF THE RIGHT LOBE’ SIZE OF THE LIVER WITH HEMODYNAMIC AND BIOCHEMICAL INDICATORS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH CARDIOVASCULAR PATHOLOGY

V. N. Karazin Kharkiv National University (Department of General and Clinical Immunology and Allergology) Kharkov, Ukraine

Relevance. Nonalcoholic fatty worsens NAFLD’s forecast due to its liver disease (NAFLD) is one of the rapid progress and the development most common pathologies in the of fibrosis and liver cirrhosis. In population. According to different conditions of clinical practice both authors the prevalence of NAFLD circumstances greatly complicate ranges between 3 and 58%, and diagnostics of NAFLD, making the among patients with overweight research of the relationship between reaches 100%. In the majority of ultrasound and hemodynamic cases (more than 55-80%) NAFLD parameters during NAFLD highly proceeds as nonalcoholic as relevant. nonalcoholic steatohepatitis, and in Aim. Optimize the diagnostic other cases (20-45%) - in the form of and forecasting of NAFLD in nonalcoholic steatohepatitis. The combination with essential presence of the latter one largely 373

ISIC-2016 Abstract book hypertension and coronary heart of the right lobe of the liver and disease. triglycerides (r = 0,684, p <0,001), Materials and methods of the the size of the right lobe of the liver research. We tested 46 patients and the level of low density with NAFLD combined with essential lipoprotein (r = 0,531, p <0,05), the hypertension (EH) of I-II degree, and size of the right lobe of the liver and coronary heart disease (CHD) of I-II the HOMA index (r = 0,622, p functional class (the average age of <0,001), the size of the right lobe of the patients is 44,8 ± 3,6 years, and the liver and speed of early diastolic average record of NAFLD - 6 4 ± 2,6 filling of the left ventricular ( r = - years). Biochemical parameters were 0,602, p <0,001), the size of the right studied on the analyzer «Humalyzer» lobe of the liver and speed of late (Germany), and ultrasound tests - diastolic filling of the left ventricular using the diagnostic system «Phillips (r = -0,509, p <0,05), the size of the IU» (USA) with a convex right lobe of the liver and end- multifrequency transducer (2-5) diastolic pressure in the left ventricle MHz. (r = - 0,668, p <0,001), the sizes of Results. According to the the right share liver and integral of clinical research palpation linear blood flow velocity in the left hepatomegaly is diagnosed in 100% ventricle (r = -0,506, p <0,05). of patients. Bearing in mind that Conclusion. The calculated hepatomegaly is stable symptom for correlation coefficients suggest that the researched contingent; this the pathological processes in the symptom has been selected for the liver and changes in biochemical and study of correlation interdependence hemodynamic parameters have a of NAFLD manifestations. NAFLD mutually potentiating impact, and patients with EH and CHD were the existence of NAFLD in patients in investigated 41 biochemical and combination with EH and CHD hemodynamic parameters including provokes changes in metabolic and a significant level of correlation hemodynamic status of patients which was obtained between the size outside of the liver and heart.

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ISIC-2016 Abstract book O. G. Sorokina, Y.Y. Zinchenko* THERAPEUTIC USE OF IMMUNOMODULATORY DRUGS IN THE TREATMENT OF PATIENTS WITH EPSTAIN-BARR VIRUS INFECTION

V. N. Karazin Kharkiv National University (Department of General and Clinical Immunology and Allergology Department of Human Anatomy*) Kharkov, Ukraine

Relevance. Currently, a antibacterial). The second group growing interest to the problem of included 94 patients (47.7%), which herpesvirus infections, including in addition to basic therapy diseases caused by Epstein-Barr employed immunomodulatory drug. virus (EBV) in particular - Infectious All patients who are admitted to the mononucleosis. 80-90% of the hospital, were examined as standard. world's population observed They were doing laboratory testing, persistence of the virus, and the including a set of generally accepted infection rate among children is methods of diagnostics (blood test, about 50%. The clinical significance urine test, seeding of mucus from the of EBV etiology of infectious nasopharynx flora, fecal pathogen mononucleosis due to involvement inoculation). in the pathological process of the Immunological examination immune, lymphatic, cardiovascular, included: determination of digestive, urinary, nervous and lymphocyte subpopulations (CD3, endocrine systems; besides EBV is CD4, CD8, CD16, CD56, CD95, CD20, the etiological agent some of CD25, HLAII cells) by flow malignant, lymphoproliferative and cytometry; Determination of autoimmune diseases; cytokine production by ELISA (IFN-a, Aim. Determine the IFN-y, IL-4). characteristics of the course of Results. Inclusion of infectious mononucleosis EBV immunomodulatory drugs in etiology (IM EBV etiology) based on complex therapy of IM EBV etiology the study of the dynamics of clinical- allowed 1.5-2 times significantly laboratory and immunological reduce the duration of the main parameters for improved therapies. clinical syndromes (p <0.01). Using Materials and methods of the immunotropic therapy helped to research. We observed 197 patients avoid complications during the with acute IM EBV. The first group convalescence period. (control group) consisted of 103 Conclusion. The use of patients (52.3%) who received basic immunomodulatory drugs in the therapy (pathogenetic, symptomatic, treatment of patients with acute

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ISIC-2016 Abstract book infectious mononucleosis EBV normalization of cellular and etiology, contributes to the positive cytokine components of immune dynamics of clinical symptoms and system.

Stroienko K., Khyzhnyak A., Khyzhnyak K. OPTIMIZATION OF TREATMENT OF COGNITIVE DYSFUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Research advisor: Khyzhnyak A.A., doctor of medicine Department of Critical Care Medicine, Anesthesiology and Intensive Therapy, Kharkiv National Medical University, Kharkiv, Ukraine

Actuality. Acute myocardial The standard scheme of treatment infarction (AMI) and its together with succinic acid was complications are uppermost in the provided for group 3. structure of incapacitation and Results. In the course of the morbidity of population. The course study an emphasis was laid on use of of AMI can be complicated by antihypoxants (tiazotic acid, succinic vascular disorders of the brain which acid) in combination with quercetin include cognitive disorders as well. in order to correct cognitive The aim. Optimization of drug insufficiency in patients with AMI. To therapy of cognitive dysfunction in estimate course and prognosis of the patients with AMI. disease the indices of cortisol and C- Materials and methods.The reactive protein of the blood within study enrolled patients with AMI and the first 24 hours of the disease were cognitive dysfunction under 60 years used. of age. Verification of diagnosis was As a result, increased cognitive carried out in accordance with valid disorders at the beginning of the protocols. Additionally,C-reactive disease and significant reduction of protein and blood cortisol were these indices in standard treatment studied. Cognitive disorders were along with antihypoxants were assessed according to the findings of observed in patients. Increased neuropsychological tests. Depending cognitive functions resulting from on therapy kind, the patients were the therapy carried out by means of divided into 3 groups. Group 1 was antihypoxants were observed as represented by patients undergoing well. It is proved by repeated a standard scheme of treatment in neuropsychological tests and AMI. The patients of group 2 normalizing of cortisol and C- received the standard scheme of reactive blood protein . treatment along with tiazotic acid. 376

ISIC-2016 Abstract book Conclusion. Disorders of higher course of the disease and mental processes (memory, praxis, improvement of the quality of life. gnosis, speech, executive functions) The use of tiazotic acid, succinic acid belong to cognitive disorders. along with quercetin for correction Consequently, early diagnosis and of cognitive insufficiency in patients correction of them in patients will with AMI claims our constant result in favorable prognosis of attention.

Sypalo Ann DEFINITION OF SORTILIN IN OPTIMIZING THE DIAGNOSIS AND TREATMENT OF DYSLIPIDEMIA IN PATIENTS WITH ISCHAEMIC HEART DISEASE AND TYPE 2 DIABETES MELLITUS

Ischaemic heart disease is one Results. Study sortilin will be of the major problems of modern used as a diagnostic marker of cardiology in all advanced countries dyslipidemia in patients with of the world. The diabetes mellitus coronary heart disease and type 2 type 2 is a marker of risk of diseases diabetes. Non-invasive study of of the circulatory system. The role of atherosclerosis of coronary artery sortilin is considered as a marker of disease in patient with ischaemic risk of dyslipidemia in patient with heart disease and type 2 diabetes ischaemic heart disease and type 2 mellitus and will be used different diabetes mellitus. sortilin level and type of The purpose is to optimize the dyslipidemia in examined patients. diagnosis and treatment of ischaemic There will be planned to assess the heart disease and type 2 diabetes impact sortilin on the progression of based on the study of sortilin, insulin, atherosclerosis and to define the role carbohydrate metabolism, lipid of sortilin in the formation of profile and indices different types of dyslipidemia in cardiohaemodynamics. examined patients. It will be analized Material and methods. There the hypolipidemic effect of using the will be used subjective (complaints, combination of statins with fibrates anamnesis of disease and life) and and omega-polyunsaturated fatty objective methods (examination, acids in patients with ischaemic palpation, percussion, auscultation), heart disease and type 2 diabetes biochemical methods, angiography of mellitus on the background of coronary arteries. conventional therapy.

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ISIC-2016 Abstract book Tabachenko Olena EFFECTS OF APELIN-12 IN THE DYNAMICS OF AMBULATORY BLOOD PRESSURE MONITORING FOR PATIENTS WITH ARTERIAL HYPERTENSION DEPENDING ON THE PRESENCE OR ABSENCE OF AN UNDERLYING TYPE 2 DIABETES

Increased blood pressure (BP) without type 2 diabetes (mean age is detected in 80% of patients with 57,1 ± 2,23). Apelin-12 was diabetes mellitus type 2. Type 2 determined by ELISA using a diabetes leads to the development of commercial test system «Human severe debilitating complications Apelin 12 (AP12) ELISA Kit», China. based on the formation, which is Results and discussion. primarily the defeat of different Hyperapelinemia has a hypotensive caliber vessels. The effect of effect in patients with hypertension adipokines in patients with type 2 and type 2 diabetes. Insulin diabetes on BP is of interest. In this resistance leading to connection interesting is apelin-12 decompensating of type 2 diabetes which exhibits hypotensive and with increasing plasma glucose and inotropic effects and stimulates the glycosylated hemoglobin is more utilization of glucose has meaningful than apelinemia. The antiatherogenic effects. result is the BP increase due to the The purpose of this research is to systolic and diastolic BP in patients evaluate changes in indices of BP with hypertension and type 2 daily monitoring and the level of diabetes. More likely an increase of apelin-12 in patients with systolic BP in patients with hypertension depending on the hypertension and type 2 diabetes is presence or absence of concomitant associated with the increase in type 2 diabetes for the analysis of glycosylated hemoglobin, and is less apelin-12 effects on BP values. likely the increase of diastolic BP is Materials and methods. The caused by a partial leveling of the study examined 105 patients with negative impact of diabetes arterial hypertension. The study apelinemia. group included 75 patients with a Conclusions. Apelin-12 is combination of hypertension and directly involved in the regulation of type 2 diabetes (mean age 60,03 ± glucose metabolism and BP in 1,17). The comparison group patients with hypertension and type consisted of 30 hypertensive patients 2 diabetes.

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ISIC-2016 Abstract book Talalaienko O.K., Romanenko O. MILD PREECLAMPSIA AS A RISK FACTOR OF OBSTETRIC COMPLICATIONS Research advisor: Romanenko O.R. Department of internal diseases №3 Kharkiv national medical university Kharkiv, Ukraine

Actuality. For a long time Results. It has been found that preeclampsia is a major cause of the uterine inertia was detected in maternal and perinatal morbidity 11 (19,6 ± 5,3%) women with and mortality. Mild preeclampsia preeclampsia and 1 (2,8 ± 1,3%) in usually does not lead to fatal the case of healthy patient. Placental consequences, however adversely abruption in labor was in 1 (1,8 ± affect the course of pregnancy which 0,6%) mother with a diagnosis of leads to the emergence of many preeclampsia, and was not common obstetric complications. This in women with physiological problem is actual for family pregnancy. Fetal distress during physicians and cardiologists because labor has been established in 9 (16,1 of necessity to carry out careful ± 4,9%) pregnant women with monitoring of this group of patients. preeclampsia and in 1 (2,8 ± 1,3%) These specialists provide care to healthy mother. Consequently a these women. cesarean section in pregnant women Aim of the study. To assess the with preeclampsia was performed in effect of mild preeclampsia on the 11 (19,6 ± 5,3%) patients and in 1 development of obstetric (2,8 ± 1,3%) case of healthy woman. complications. Bring the significance The number of normal births of this problem for family physicians declined to 55.4 ± 6.6% and 94.4 ± and cardiologists. 3.8%, respectively. Materials and methods. Conclusions. Official guidelines Retrospective analyses of 92 clinical do not include any treatment of mild cases, randomly selected from the preeclampsia but recommend archives of the birth histories were cardiologist consultation. In reviewed. 36 cases of healthy pregnant women with mild patients and 56 cases of birth with preeclampsia compared with healthy mild preeclampsia were analyzed. women was observed statistically Data delivery and postpartum significant increase in the complications were studied. development of obstetric Frequency of occurrence of disease complications. As a result, there is a was calculated. The reliability of decrease in the number of normal differences was assessed by deliveries. Thus, it is necessary to Student's test with significance level develop special tactics of pregnancy (p <0.05). and childbirth in this category of

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ISIC-2016 Abstract book patients and their monitoring by cardiologists and family physicians.

Teclebrhan Mosay Berihu, Lermak Alexandra Sergeiyevna BEHCET'S DISEASE Research advisor: associate Professor,PhD Titova Anna Department Of Internal Medicine No.2 Kharkiv National Medical University Kharkiv, Ukraine

Actuality: Behcet’s is a rare instead in about 49% of these form of vasculitis that affects small patients they have an increase in and medium sized vessels, but it also HLA-DRB1. owes it’s lethal damage to it’s Aim: Trying to understand the affinity for affecting large vessels as principle of” diagnosis of exclusion” well. Mainly occurs in the ages of all other possibile diseases which between 20-40, in Middle Eastern may mimic Behcet’s disease or vice people and South East Asians, in versa. Turkey(400/100,000 cases were Material And Methods: A reported anually), Iran, Saudi Arabia, general physical examination & Greece, Japan, Korea and China , proper clerking of a patient with the there have also been reports of it disease proves to be benefical in the affecting people in Western societies long of run of trying to diagnose the namely in the USA( 1/170,000 cases disease, as the manifestations of were reported). Predominantly Behcet’s may lack specifity in some males are affected by the disease in patients but not all ,further methods the middle eastern countries, while that can be used are laboratory in south east asian and western methods such as CBC,PCR,genetic countries, females are most affected screening for the allele, Imaging by the disease. It’s an interesting method’s such as MRI disease in such that it needs to be w/T2weighting, MRI-angiography, differentiated from other forms CT-scan, Angiograms,Pathergy’s Vasculitis, autoimmune disorders, Test, CSF, and biopsy of the lesions. infectious diseases and other Result: Pathergy’s test is deficency related syndromes etc. It is usually positive in most patients, known that 80% of the people with except for Westerners, it shows only the disease have an increased HLA- one-third of people suffering from B51 allele count, this allele is usually the disease test positive, MRI and CT found in people of Middle Eastern show either acute or chronic and South East Asian origin, while in progressive lesions of the brain, patients of Western origin it has angiograms & MRI angiography been proved that they lack this allele, show the extent of vascular damage 380

ISIC-2016 Abstract book caused by Behcet’s, Biopsies are Conclusions: The principle of done to rule out other pathologies using “diagnosis of exclusion” in .CSF fluid analysis reveals both Behcet’s Diseases is due to the fact neutrophilic and lymphocytic nature that the disease in itself mimics of pleocytosis in the case of other diseases and vice versa. The meningoencephalitis caused by rarity of the disease leads to it being Behcet’s, this helps exclude either misdiagnosed and often poorly bacterial or viral origin of treated ,hence it’s most lethal encephalitis. manifestations take course swiftly.

Turmanidze Ketevani Iraklievna BIOMARKERS OF LEFT VENTRICLE REMODELING IN OVERWEIGHT PATIENTS WITH ESSENTIAL HYPERTENSION Research advisor: candidate of medical sciences Demidenko Ganna Valeriivna Department of Fundamentals of Internal Medicine #1, Fundamentals of Bioethics and Biosafety Kharkiv National Medical University Kharkiv, Ukraine

Aim of our investigation was RWT=(posterior wall thickness studying of cytokines activity in (PWT)+interventricular sept overweight patients with essential thickness (IVT)) / diastolic size). hypertension depending on Patients were divided according to peculiarities of left ventricle gender and changes in relative wall remodeling. thickness (RWT). Material and methods: 20 Results: the most part of patients were examined. Age 30-80. patients had moderate changes of Standard clinical, laboratory and RWT. According to our investigation, instrumental methods were used. LV remodeling was developed Oncostatin M and IL-6 were rateably to anamnesis of the disease measured using ELISA Kit, and SBP. Patients with increased RayBiotech, Inc. Ultrasound of the RWT were characterized by heart was performed in accordance significantly higher levels of with the recommendations of the Oncostatin M 27,53±2,43 and IL-6 European and Ukrainian Association 20,01±1,61 comparing to control of Echocardiography. Relative wall group (7,90±0,13 and 2,58±0,13), thickness (RWT) that reflects and ones with normal RWT geometrical changes of left ventricle (20,00±3,44 and 15,28±1,68). (LV) was calculated as Correlation analysis showed positive 381

ISIC-2016 Abstract book relationship of Oncostatin M, IL-6 myocardial mass r=0,45, р<0,05) in with SBP, DBP (r=0,43, and r=0,55 patients with essential hypertension. correspondently, р<0,05), Conclusion: results of our anthropometric measurements investigation showed involvement of (waist ratio - r=0,74, р<0,05) and oncostatin M, IL-6 in process of LV parameters of LV remodeling (LV remodeling in overweight patients with essential hypertension.

Viltsaniyk O.O., Viltsaniyk O. COMMUNITY ACQUIRED PNEUMONIA AND OPIOID DRUG ADDICTION: CLINICAL COURSE AND TREATMENT RESULTS Research advisor: Mostovoy Y.M., DM, professor Department of propedeutics to internal medicine Vinnitsa Pirogov Memorial National Medical University, Vinnitsa, Ukraine

Actuality. The problem of the laboratory, biochemical tests, treatment community-acquired enzyme-linked immunosorbent pneumonia (CAP) is one of the most method, microbiological studies and actual health and social issues. morphological studies, determined Aim. To define features of the level of endogenous intoxication flow and effectiveness of community- (EI). acquired pneumonia treatment by Results. The study found that traditional methods in patients with severity of disease is caused by the opium drug addiction. presence of hidden polyorgan Matherials and pathology on patients with opium methods. The object of the study addiction to which also added was 89 patients with severe CAP. intoxication syndrome, due to the Patients were divided into two lungs inflammation, which by itself representative group: the main leads to damage of internal organs. It group (42 patients with opium drug was established that pneumonia in addiction and CAP) and comparison these patients is caused by highly group (47 patients with severe CAP). virulent, antibiotic resistant bacteria The study of changes in the internal and fungi, susceptible to antiseptics. organs conducted in 32 died drug Using of the conventional methods of addicted patients. The study of CAP treatment have low efficiency changes in the internal organs in CAP and is accompanied by the prolonged conducted on experimental hospitalization of patients, leads to pneumonia on 35 rats. Evaluation of the development of destructive treatment results was carried out by 382

ISIC-2016 Abstract book changes in the lungs and is main group is associated with associated with high mortality. presence of multiple organ Conclusions. CAP in patients pathology. Traditional approaches to with opium drug addiction has the treatment of severe CAP in that severe flow with the development of patients requires significantly systemic inflammatory response (p<0,05) longer hospitalization, syndrome ( higher than in corsed by a frequent development of comparison group (p <0,05)). destructive changes in the lungs and Severity of CAP in patients of the higher mortality.

Vivcharuk Yaryna Vasilyvna MENSTRUAL IRREGULARITIES IN WOMEN OF REPRODUCTIVE AGE WITH HYPOTHYROIDISM AGAINST THE BACKGROUND OF AUTOIMMUNE THYROIDITIS Research advisor: assistant Nizhinskaya-Astapenko Zorina Petrivna Departmen of Endocrinology Vinnitsa National Pirogov Memorial Medical University Vinnitsa, Ukraine

Actuality: The structure of with autoimmune thyroiditis with endocrine diseases are among the reduced function. leaders thyroid pathologies Materials and methods: To (48.67%), of which a large part is achieve the goal were observed 90 autoimmune thyroiditis. female outpatients Vinnytsia region Autoimmune disease tyreoyidyt- aged 15 to 35 years with the disease autoagressive, autoimmunization at the AIT VOKED for 2015 thyroid antigens morphological Results: We found that disease manifestation of which is duration in women was: up to 6 plazmotsytarna and lymphoid months - in 18 women (20%) 6 infiltration of the thyroid gland, months-1 year -23 (25.6%), 1-5 Autoimmune tyreoid disease is years, 37 (41.1%), 5-10rokiv-12 important for women of childbearing (13.3%). U67 women diagnosed with age, pathology of function results hypertrophic studied form of AIT pathology of ovario-menstrual cycle, (74.4%). The 23 women- Atrophic infertility, pregnancy pathology and form of AIT (25.6%). Complaints that has a negative impact on mental occur in women discomfort and health-Ner. compression of the neck in 67 Aim: To investigate violations (74.4%)., Excess body weight, 70 ovario-menstrual cycle in women women (65%) Dry skin- 65 (72.2%).

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ISIC-2016 Abstract book constipation- 78 (86 .6%). Heterogeneity ehostruktury in 90 Tachycardia-50 (55.5%). Puffiness of women (100%) of women surveyed face-to-54 (60%). decreased in there menstrual cycle as: physical activity- 85 (94.4%). The dysmeonreya-in 65 women (72.2%), level of thyroid hormones on first primary amenorrhea -5 (5.55%), addressed was: 9,06-30,84mkmol secondary amenorrhea-30 (33.3 %), TSH / ml; free T4 0,56-4,35; ATdo oligomenorrhea-38 (42.2%) 65-329,6 garbage. The beginning of Conclusion: Based on the the menstrual function, 11-13 years - processed information can conclude in 45 women (50%), 13-15 years, 36 that in women of reproductive age (40%),> 15 years, 9 (10%). With with hypothyroidism AIT against the ultrasound diagnosed investigated as backdrop of the most common form follows: increase in thyroid volume of irregular menstruation is 67 women (74.4%) decrease in dysmenorrhea, often - volume in 23 (25.6%). The presence oligomenorrhea and amenorrhea of units in 78 women (86.6%). often -secondary

Yermak Oleksandra Sergiivna, Borzova-Kosse Sofia, Adamsky Mark DYNAMICS OF COPEPTIN AND CARDIOHAEMODYNAMIC'S INDICATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH OBESITY Research advisor: Kravchun Pavlo, professor Department of internal medicine, clinical imunology and allergology Kharkiv national medical university, Kharkiv, Ukraine

Acute myocardial infarction copeptin is promising in this cohort (AMI) - is leading nosology in the of patients. structure of coronary heart disease The purpose of the present research (CHD). Nowadays the attention of is to optimize AMI diagnosis by researchers aimed at identifying the examining the copeptin's dynamics impact of obesity as a risk factor for in patients with AMI depending on cardiovascular disease and as a the concomitant obesity, and to factor that contributes to the analyze the relationship between progression of CHD. The imbalance this marker and of vasoconstrictor and vasodilator cardiohaemodynamic's indicators. systems in patients with AMI and Research methods. The study concomitant obesity plays a dramatic included 80 patients with AMI, role in the progression of these among which 50 patients were diseases explains studying of diagnosed obesity, 30 people had normal body weight. Body mass 384

ISIC-2016 Abstract book index (BMI) was determined by the found differences in patients with formule: BMI (kg/m2) = AMI and obesity: the end-diastolic weight/(height) 2. Copeptin volume’s(EDV) level was higher by determined by ELISA using a set of 20,4%,the end-systolic reagents «Human Copeptin» volume’s(ESV) – by 28,5%, the end- (Biological Technology, Shanghai). diastolic diameter (EDD) – by 15,5%, Echocardiography was performed to the end-systolic diameter– by 17,6% all patients . Statistical analysis of the and the ejection fraction (EF) lower data was conducted using statistical by 15,1% compared with patients software package «Microsoft Excel». without obesity. We found a direct Data are presented as mean values correlation between copeptin and and the error of the mean. Statistical EDV (r = 0,25, p <0,05), ESV (r = 0,36, significance was determined by p <0,05), EDD (r = 0,47, p <0,05) and various secondary criterion F - inverse correlation with EF (r = - Fisher. Analysis of relationships 0,23, p <0,05). conducted using Spearman's Conclusions. Copeptin's level correlation (r). was highier in the presence of Results. Copeptin’s level was obesity in patients with AMI. significantly higher in patients with Increased copeptin's level associated AMI and obesity(129,6% ) compared with left heart cavities dilatation and with patients without obesity. reduced contractility in patients with Hemodynamic parameters also AMI and concomitant obesity."

Yeryomenko G.V. THE ROLE OF VON WILLEBRAND FACTOR IN THE DEVELOPMENT OF INFLAMMATION IN PATIENTS WITH ASTHMA Kharkiv National Medical University (Propedeutics of Internal Medicine №2 and nursing, Ukraine, Kharkiv)

Introduction: Metabolic diseases Materials and methods: Involved and respiratory occupy leading 103 patients and a control group of 15 positions in Ukraine. patients. All patients were divided Objective: To determine the role of into 2 groups: main group - asthma von Willebrand factor (vWF) in the patients without diabetes type 2 and development of endothelial group comparisons of asthma in dysfunction in patients with asthma of combination with diabetes type 2. In moderate severity is not controlled addition to general clinical with and asthma without diabetes examination in all patients studied type 2. features of asthma using a 385

ISIC-2016 Abstract book questionaire for quality of life ACQ-5 patients with asthma and patients asthma symptoms, as well as with comorbidity (p <0,05). The examined the external respiratio correlation analysis between the function (ERF), vWF is determined by clinical course of the disease and the a set of TECHNOZYM® vWF: Ag functional data and laboratory tests ELISA. showed a positive correlation with the Results: In the group with combined number of night attacks and vWF (r = pathology observed violation of 0,76) and negative - FEV1 and vWF (r spirometry on the mixed type: a = 0,65) in patients with primary and moderate decline in FEV1, and all the combined groups. high-speed performance combined Conclusions: Increased levels of von with a fairly pronounced decline in Willebrand factor is an early predictor rates vital capacity (VC), FVC. of endothelial damage in patients with Obtained significant differences asthma. BA combination with type 2 between the indicators ERF in diabetes leads to the progression.

Zaikina T.S., Butrimova I.A. MARKERS OF COMPLICATED COURSE OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH CONCOMITANT DIABETES MELLITUS TYPE 2 Research advisor: Kravchun P.G., doctor of medicine Department of internal medicine№2, clinical immunology and allergology, Kharkiv National Medical Iniversity, Kharkiv, Ukraine

Actuality. Mortality among Materials and methods. 70 patients with AMI and diabetes patients were enrolled in this study. mellitus is higher than in patients They were divided in two groups: I without diabetes mellitus, but the group- 23 patients with markers of complicated course are complicated course of AMI; II still unknown. group- 47 patients with The aim is to establish the uncomplicated course of AMI. markers of complicated course of Levels of von Willebrand factor, acute myocardial infarction (AMI) sVE-cadherin and sCD40-ligand in patients with concomitant were evaluated using immunoassay diabetes mellitus type 2 based on analysis twice at the first and tenth the estimation of endothelial days of AMI. Statictical analysis was damage markers – von Willebrand made with the evaluation of factor, sVE-cadherin and sCD40- average levels (M), error of the ligand. average level (m), reliability of

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ISIC-2016 Abstract book differences (p) between and -22,5±1,5% accordingly parametrical samples. (p˂0,01). There were no Results. Average levels of von differencies in levels of sVE- Willebrand factor in the I group cadherin in two groups (1,82±0,04 were significantly higher than in II ng/ml and 1,75±0,04 ng/ml group ‒ 2,12±0,06 ng/ml and accordingly (p˃0,05). 1,94±0,03 ng/ml accordingly Conclusion. Complicated (p˂0,01). Insufficient reduction of course of acute myocardial this parameter under the influence infarction (AMI) in patients with of treatment was also associated concomitant diabetes mellitus type with development of complications 2 is associated with higher levels of (-14,6±1,1% and -18,1±0,8% von Willebrand factor and accordingly (p˂0,01). Insufficient insufficient reduction of this reduction of sCD40-ligand levels parameter under the influence of correlated with complicated course treatment which confirm negative of AMI in comparison with patients impact of endothelial damage. without complications (-16,3±1,7%

Zaikina T. S., Dielievska V. Yu., Jeena Justin ALDOSTERONE INVOLVEMENT IN CHRONIC HEART FAILURE DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE Research advisor: proffessor d.m.n. Kravchun Pavlo Internal medicine №2 and clinical immunology and allergology Kharkiv National Medical Iniversity Kharkiv, Ukraine

Aim: To evaluate the effect of ESH / ESC criteria. The comparison aldosterone on lung function in group consisted of 25 patients with patients with chronic obstructive AH 2 stage. 20 healthy volunteers, pulmonary disease (COPD) in matched for sex and age, served for combination with arterial the control group. Patients hypertension (AH). performed clinical, laboratory tests, Materials and methods: The spirometry and determination of the study involved 55 patients with level of aldosterone by enzyme COPD 2 and 3 degrees of airflow immunoassay. obstruction with concomitant AH of Results: Aldosterone levels in the 2nd stage. The diagnosis of COPD patients with chronic obstructive of groups B and C was set according pulmonary disease and hypertension to GOLD 2014 guidance. AH was were significantly higher than of the diagnosed in accordance with the control group (63,2 ± 3,4 and 43,1 ± 387

ISIC-2016 Abstract book 1,2 pg / ml, respectively, p <0.05). volume (r = -0,62; p = 0.002). As in Patients of the studied group showed the literature there is experimental higher aldosterone levels than evidence that the lung epithelium is a patients with isolated AH (63,2 ± 3,4 physiological target tissue for as compared to 56.2 ± 2.21 pg / ml, p aldosterone, we can assume = 0,023). Differences in serum levels fibrosing influence of aldosterone on of aldosterone in the progression of the structure of the lung tissue. bronchial obstruction has not been Conclusions: Increased found, though they tended to aldosterone levels in patients with increase (p> 0.05). Serum chronic obstructive pulmonary aldosterone showed a negative disease in combination with arterial correlation with forced expiratory hypertension are associated with volume in 1 second (r = -0,32; p = worsening of lung function that may 0.034), vital capacity (r = -0,34; p = be used to predict bronchial 0.022) and peak expiratory flow obstruction in these patients.

Zaozerskaya N.V., Iraki Hamza QUALITY OF LIFE AND PSYCHOLOGICAL TRAITS OF CHARACTER IN PATIENTS WITH DIFFERENT KIND OF CARDIOVASCULAR PATHOLOGY Kharkiv National Medical University, department of internal medicine № 2

Introduction: Cardiovascular patients with cardiovascular diseases are very common diseases diseases (CVD): essential in human population. Essential hypertension (EH), CAD. Subjects hypertension and coronary artery were examined in the Kharkov disease (CAD) may deteriorate the Regional hospital. The study enrolled quality of patient’s life, has an impact 15 patients with EH and 12 pts with as on physical so on emotional status CAD and heart failure. 10 healthy of the patients. The purpose of this persons were observed as control research investigation is to learn and group. M-69%, F-31%; mean age in estimate influence of the clinic- group with EH - 53.7 years, CAD – psychological factors on the quality 56.8 patients: 6 – angina pectoris, 6– of life of patients with cardiovascular atherosclerotic cardiosclerosis. pathology. Results: Worsening of quality Methods: We used Short Form of life was revealed in both groups Health Survey-36 (SF-36) EH and CAD. For people with EH questionnaire, psychological tests: more pronounced decreasing of role Spielberg, EPI, Schmieschek, socio- physical functioning, general health demographics and clinical parameter perceptions, role limitations due to characteristics for examination of the emotional problems and norm - 388

ISIC-2016 Abstract book based general mental health was introversion, and high level of detected. For EH group: physical personal anxiety and situational functioning, general health anxiety were found in patients with perceptions, vitality, energy or CAD. Choleric and melancholic fatigue, bodily pain were more patients were revealed in EH group, significantly marked. Personal sanguine and phlegmatic – in CAD psychological status of the patients group. with EH showed more high level of

Zhuravlyova A., Ognieva O. NONINVASIVE DIAGNOSIS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC LIVER DISEASE Department of Internal Medicine №3 Kharkiv National Medical University Kharkiv, Ukraine

Introduction: liver fibrosis is Materials and Methods: known to be a pathological process different non-invasive methods were that is considered to be consequence studied to access their ability to of a lot of liver insults that causes estimate the degree of liver damage chronic liver injury. Hepatic fibrosis due to fibrosis. can occur in response to viral, Discussion: novel technologies immune, and toxic-metabolic insults such as transient hepatic elastography and consists of an accumulation of and magnetic resonance imaging fibrillar extracellular matrix (ECM) (MRI) elastography show promise as components. It is mostly considered to noninvasive methods of testing for be irreversible because it is just like a hepatic fibrosis but they have small silent killer as it doesn’t show any value in identifying early stages of particular signs and symptoms. But fibrosis and low-grade inflammation. early diagnosis could be helpful as in Separate investigation of direct and early stages it is somehow reversible indirect serum markers of synthesis and doesn’t progress to serious liver and degradation of ECM do not involvement. correspond to the exact organ or stage Aim: to estimate the usage of of the process. Combination of these non-invasive diagnostic tests in serum markers is used to access the patients with chronic liver diseases for liver function and the rate of finding early morphological changes in inflammation in the way of different liver. panels interpreted with scoring systems. Fibrotest is used for 389

ISIC-2016 Abstract book quantative and qualitive diagnosis of sensitivity if compare results to liver liver fibrosis and Aktitest to assess the biopsy, but still cannot replace this necroinflammatory activity, and the procedure which is considered to be a panel FibroMaks in addition includes «gold standard». diagnostic algorithms Steatotest to Conclusions: in cases when liver determine the stage of steatosis, biopsy cannot be performed or there Ashtest to determine the degree of is need in early diagnosis of activity of alcoholic steatohepatitis morphological liver changes doctors and Nashtest to evaluate the stage of may use new non-invasive techniques nonalcohol steatohepatitis in patients that are quite reliable and relevant for with metabolic syndrome. These the liver disease diagnosis. methods have high specificity and

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ISIC-2016 Abstract book CONTENTS

BIOMEDICAL SCIENCES ...... 3

ALEKSANDROVA С., SHAPOSHNIK S...... 4 AMYLOCLASTIC POWER OF BUCCAL EPITHELIUM CELLS AND THE INCIDENCE OF RESPIRATORY DISEASE AMONG THE CHILDREN OF SCHOOL AGE ...... 4 ANMALUGSI PIUS ...... 5 INTERRELATION BETWEEN SEROTONIN CONTENT IN CEREBELLUM AND REGIONS OF EMOTIOGENIC LIMBICOCORTICAL SYSTEM OF BRAIN IN THE SUBMISSIVE AND DOMINANT ...... 5 AVILOVA O.V...... 6 METASTRUCTURE OF THE SPLEEN UNDER THE IMPACT OF TRYGLYCIDYL ETHER OF POLYOXYPROPYLENE TRIOL ...... 6 BERDIKOVA JULIA ...... 8 FEATURES OF PENETRATIVE ACTION OF BULLETS AT SHOTS FROM AN AIR RIFLE DEPENDING ON A DISTANCE OF SHOTS ...... 8 BIBHU CHARAN NAYAK, SANTOSH ACHARYA, SANIPINI SWATI ...... 9 SHORT TERM MEMORY: THE FEATURES OF REMEMBERING ...... 9 BOIKO KATERYNA OLEKSANDRIVNA, TERLETSKA EVGENIA OLEKSANDRIVNA ...... 10 THE IMPACT OF PHYSICAL PERFORMANCE ON THE QUALITY OF LIFE OF YOUNG PEOPLE ...... 10 BЕZEGA E. V...... 11 MITES – PATHOGENS EAR MANGE (OTODECTOSIS) ...... 11 CHERNIAKOVA A. M...... 12 THE ROLE OF S.AUREUS IN THE ETIOLOGICAL STRUCTURE OF INFECTED WOUNDS IN BURN PATIENTS...... 12 CHIRVA A.V., SOKOL E.N...... 13 STUDY OF THE EFFECT OF BACKGROUND COLOR AND FONT OF TEXT DOCUMENTS ON THE PROCESS OF ADAPTATION OF MEDICAL STUDENTS TO INTELLECTUAL LOADS ...... 13 DOBROVOLSKAYA E.M., MARYENKO N.I...... 15 VARIANT ANATOMY OF THE LOBULES OF THE POSTERIOR LOBE OF THE HUMAN CEREBELLUM ...... 15 DUTCHAK S.R., PRIADKA T.M...... 16 MEDICINAL ANALGESIC AND ANTIPHLOGISTIC THERAPY WITH AN EXTRACT COMFREY ...... 16

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ISIC-2016 Abstract book S.R. DUTCHAK, T.M. PRIADKA ...... 17 MEDICINAL ANALGESIC AND ANTIPHLOGISTIC THERAPY WITH AN EXTRACT COMFREY ...... 17 ZUPANETS I.A.1, KARNAUKH E.V.2, FILYANIN S.I.2 ...... 18 BODY MASS INDEX AS ONE OF THE MARKERS OF METABOLIC PROCESSES IN BIOEQUIVALENCE STUDIES ...... 18 GANIZADE N.D., SHEYAN D.N., LIUTENKO M.A., TOPCHYI S.V...... 18 INFLUENCE OF THE ELECTROMAGNETIC RADIATION ON THE CENTRAL NERVOUS SYSTEM ...... 18 GUBIN N., POGODINA E., DROBOTOVA K., YARMAK I...... 20 FORENSIC-MEDICAL EVALUATIONS DAMAGESOF RESPIRATORY SYSTEM WITH ACUTE RESPIRATORY FAILURE ...... 20 HLADKYKH F. V., STEPANIUK N. H., SOKYRKO M. V...... 21 THE EFFECT OF VINBORON ON THE EXPRESSION PROCESSES OF APOPTOSIS IN GASTRIC MUSOCA WITH IBUPROFEN-INDUCED GASTROPATHY IN RATS 21 HOLNIK YANA, A.V. MOROZOV ...... 22 COMPENSATION OF CARBOHYDRATE METABOLISM AS A FUNCTION OF PHYSICAL ACTIVITY OF CHILDREN WITH DIABETES MELLITUS ...... 22 HOLOVANOVA A.YU., PYSARENKO G.N...... 23 ANTISTRESS ACTION OF PYRACETAMUM FOR THE IMMOBILIZED RATS OF 2-Х OF MONTHLY AGE ...... 23 HRYHOROVA M.V, SOKOL A.A...... 24 ADOLESCENT’S SENSORINEURAL HEARING LOSS. DRUGS USED IN TREATMENT ...... 24 IVANOVA V.S., SOKOL H.N...... 25 INFLUENCE OF THE EFFECTIVENESS OF THE WORK OF PROPRIOCEPTIVE SENSORY SYSTEM ON THE FORMATION OF ADAPTATION TO THE INFORMATIVE STRESSOR ...... 25 KALASHNIK E.I., SHEYAN D.N., LIUTENKO M.A., TOPCHYI S.V...... 27 THE REASONS AND KINDS OF DALTONISM. CHANGES OF THE COLOUR, RECEPTORS OF THE EYE ...... 27 KALINICHENKO D...... 28 INFLUENCE OF NUTRITION AND METHOD OF THE POWER FOREIGN STUDENTS ON THE STATE OF THEIR HEALTH ...... 28 KHALIMOV E.G., SOKOL A.A...... 29 PHYSIOLOGICAL CHARACTERISTICS OF CEREBRAL CIRCULATION IN THE PRENATAL ...... 29 392

ISIC-2016 Abstract book KHROMEY E...... 30 THE INFLUENCEOF LOW FREQUENCY LASER LIGHT ON THE SENSITIVITY OF ERYTROCYTES GLYCOCALIX ...... 30 KNIGIN M...... 31 FACTORS, WHICH INFLUENCE THE PROCESS OF SELF-EXCITATION OF THE HEART ...... 31 KOLODYEZNA T.YU., DOBROVA V. YE...... 32 THE ANALYSIS OF THE UKRAINIAN RECS WORK AS A PART OF THE TRIAL SUBJECT PROTECTION SYSTEM ...... 32 KOLOTILOV A., LIKHA V., KOVALIOV M...... 33 THE INVESTIGATION OF THE MENTAL EFFICIENCY IN THE DYNAMICS OF THE EDUCATIONAL MOTIVATION DEVELOPMENT IN STUDENTS WITH THE INDIVIDUAL CHARACTERISTICS OF THE INNER TIME FLOW RATE ...... 33 KORSUNOV K.V ...... 35 MONOAMINE CONTENTS IN CEREBELLUM OF BRAIN IN SUBMISSIVE AND DOMINANT RATS ...... 35 KUZNETSOVA D...... 36 RECENT DATA ABOUT MOLECULAR UNDERPINNINGS OF METABOLIC SYNDROME PATHOGENESIS ...... 36 MARKIV A.I...... 37 FEATURES OF THE CARDIOMETABOLIC DISORDERS AND STRUCTURAL- FUNCTIONAL STATE OF MYOCARDIUM IN PATIENTS WITH HYPERTONIC DISEASE AND DIABETES MELLITUS ...... 37 MARTYNENKO A.A., ZELENSKAYA A.N...... 38 PSYCHO-PHYSIOLOGICAL FACTORS OF ADAPTATION IN MEDICAL STUDENTS TO PROLONGED ACTION OF INFORMATIONAL STRESS ...... 38 MASLOVA J...... 39 FEATURES OF THE ACCOMMODATIVE-CONVERGENCE SYSTEM OF TEENAGERS ...... 39 MATSAK DENIS ...... 41 ANATOMY OF POLYCISTIC KIDNEYS ...... 41 DR. ALEXANDER MOKANYUK, DR. MAHAMMAD NOVRUSOV, DR. LESIA YEKENINA ...... 42 COMPUTER PROGRAM MATHCAD AS AN OBJECTIVE WAY TO DETERMINECOLOR (FOR THE FORENSIC MEDICAL PRACTICE) ...... 42 MOSKALENKO V., SIRENKO V...... 43 MAGNESIUM LEVEL IN PANCREAS OF RATS AND THEIR OFFSPRINGS IN LESS NUTRIENTS DIET CONDITION...... 43 393

ISIC-2016 Abstract book MUKHERJEE PRATIBHA ...... 44 INTERRELATION BETWEEN DOPAMINE CONTENTS IN CEREBELLUM AND EMOTIOGENIC LIMBICOCORTICAL SYSTEM REGIONS IN RATS WITH DIFFERENT BEHAVIOR TYPES ...... 44 NABOK T.A., ZELENSKA A.N...... 45 ON THE QUESTION OF THE EFFECTIVENESS OF PSYCHOPHYSIOLOGICAL METHODS OF DIAGNOSTICS OF EDUCATIONAL MOTIVATION OF MEDICAL STUDENTS ...... 45 NAZAROV DMYTRO IHOROVICH ...... 47 ADVANCES OF NANOPARTICLE-BASED TARGETED DRUG DELIVERY FOR CANCER TREATMENT ...... 47 ONIKOVA A., OTCHIK A...... 48 EXPERIMENTAL STUDY OF COPPER ION ROLE IN MECHANISMS OF NEPHROPATHY ...... 48 PAVLICHUK E. A., PANICH R. V., KARNAUKH E. V...... 49 HOW BRANDS OF DRUGS DEFEND THEIR PRODUCTS AGAINST OF FALSIFICATION? ...... 49 POLIAKOVA VERONIKA VIACHESLAVOVNA, KRAVCHENKO MAKSIM ...... IUREVICH 50 THE INFLUENCE OF ELECTROMAGNETIC RADIATION ON THE LEVEL OF RATS STEROID HORMONES ...... 50 POLIKOV G., KARNAUKH E...... 51 INNOVATIVE BIO-TECHNOLOGICAL DEVELOPMENTS OF UKRAINIAN SCIENTISTS IN THE AREA OF PROBIOTICS ...... 51 PRISICH K.S., SHULGA L.I., BEZTSENNA T.S...... 52 STUDY OF THE INFLUENCE OF PHARMACEUTICAL FACTORS IN THE DEVELOPMENT OF DENTAL FUNDS – LIQUID EXTRACT OF BURNET ...... 52 PUSHKAR L., BONDARENKO V...... 53 THE NEW METHOD OF FORENSIC MEDICAL DIAGNOSTIC OF ACUTE ALCOHOL POISONING...... 53 SADER ABBAS, ADEEM F.Y., VASYLIEVA O...... 55 THE EFFECT OF CHRONIC ELECTRICAL STIMULATION ON THE MUSCLES PHYSIOLOGICAL PROPERTIES IN PATIENTS WITH MYOTONIC DYSTROPHY TYPE 1 ...... 55 SAVELIEVA E.V., LEVASOVA O.L., MASIH T...... 56

394

ISIC-2016 Abstract book EFFECTS OF CAFFEINE, ACETAMINOPHEN, CARBAMAZEPINE AND THEIR COMPOSITIONS ON LIPID PEROXIDATION AND STATE OF THE ANTIOXIDANT SYSTEM IN A BLOOD SERUM OF RATS ...... 56 T.M. SAZONOVA, J.G. ZHADAN ...... 57 DETERMINATION OF CATALASE ACTIVITY AFTER MODELING CRYONECROSIS OF THE MYOCARDIUM IN RATS ...... 57 SHARAPOVA A.E...... 59 FUNCTIONAL FEATURES OF THE AMYGDALA ...... 59 SHARAPOVA A.E., BAUSOVA O.B...... 60 INTERSYSTEM RELATIONS OF CARDIORESPIRATORY SYSTEM IN MEDICAL STUDENTS DURING THE STUDYING IN UNIVERSITY ...... 60 SHCHOLOK T., KUKUSHKINA M...... 61 THE POSSIBILITY OF CORRECTING OF ELASTIN SYNTHESIS IN BLOOD VESSELS ...... 61 SHENGER S.V., BULYNINA O.D...... 62 FEATURES OF MANIFESTATION OF COMMUNICATIVE ABILITIES AMONG YOUNG PERSONS WITH DIFFERENT TYPES OF FUNCTIONAL ASSYMETRY ..... 62 SHUBINA M.V...... 64 APPLICATION OF A CANCER DRUG FOR NEW INDICATIONS - TREATMENT OF NEURODEGENERATIVE DISEASES OF THE CNS ...... 64 STUPNYTSKYI MYROSLAV ANDREW ...... 65 POSTTRAUMATIC COAGULOPATHY IN PATIENTS WITH THE SEVERE COMBINED THORACIC TRAUMA...... 65 SUKHONOSOV R., VOVK O., IKRAMOV V., SHMARGALEV A., SHAFRANETSKAYA V...... 66 THE CRANIOMETRY OF THE SKULL VAULT AT ADULT PEOPLE ...... 66 TARASENKO D...... 67 THE INFLUENCE OF BLOOD GROUP ON THE FORMATION OF HUMAN CHARACTER ...... 67 TERLETSKA YEVHENIA OLEXANDRIVNA, BOYKO KATERYNA OLEXANDRIVNA ...... 69 THE EVALUATION OF QUALITY OF LIFE OF YOUTH DIFFERENT LEVELS OF PHYSICAL PERFORMANCE ...... 69 TOKAREVA I.L...... 70 MEDICAL RESEARCH IN METROLOGY ...... 70 TOKAREVA IL ...... 71 SYSTEM METROLOGICHETION PROVIDE MEDICAL EQUIPMENT IN HEALTH CARE ...... 71 TOPCHII S.V., IZMAILOVA L.V...... 72 395

ISIC-2016 Abstract book STRUCTURAL ORGANIZATION OF NERVES OF THE SUPERFICIAL TEMPORAL AND FACIAL ARTERIES ...... 72 TSIMOKH I., ZHURAVLEVA P...... 73 СOMPLEX GENETIC DISORDERS ...... 73 VDOVYCHENKO E., KLIMCHUK O...... 75 ANATOMIC-FUNCTIONAL CHARACTERISTICS OF THE LOWER LIMB JOINTS IN CASES OF FLAT-FOOTEDNESS ...... 75 YUNCOVA K.O., YURKINA I.S., KOLISNIK I.L...... 76 AGE-RELATED CHANGES IN VESSELS OF ADRENAL GLANDS ...... 76 ZAPOROZHCHENKO Y. S., MASLOVA N. M...... 77 INFLUENCE OF MILD EMOTIONAL STRESS ON THE HEART RATE ...... 77 ZAVGORODNIY. A. KARNAUKH E., ...... 79 BIOTECHNOLOGICAL INNERVATION AGAINST THE HEPATITIS C ...... 79 J.G. ZHADAN, T.M. SAZONOVA THE STUDY OF THE CRP LEVEL IN BLOOD SERUM IN DIFFERENT TERMS AFTER THE SIMULATED CRYONECROSIS OF MYOCARDIUM ...... 80 DENTISTRY ...... 81

AL-SALIHI A.I...... 82 LONG –TERM RESULTS THE USE OF DIODE LASER 940 ΜM IN THE DURING PERIODONTAL THERAPY ...... 82 BAGHDADI MOUSTAFA, NADHIM AHMED, ALKHDO ALI, ALMAHO MUSTAFA, PALII O.V...... 83 STATISTICAL ANALYSIS OF HYGIENE TOOTHPASTES BY STUDENTS OF FACULTY OF DENTISTRY ...... 83 BELYAEV P.V...... 84 NEW APPROACHES TO COMPREHENSIVE TREATMENT INFLAMMATORY DISEASES OF MAXILLO FACIAL REGION ...... 84 BOGATU SVITLANA ...... 85 IS THE ASSOCIATION BETWEEN GASTRIC HELICOBACTER PYLORI INFECTION AND ORAL PATHOLOGY? ...... 85 DOTSENKO D., VISHNEVETSKAYA A...... 86 EARLY DETECTION OF PEMPHIGUS VULGARIS IN THE ORAL CAVITY ...... 86 KISHKAN A., MARINKO Z., TISHCHENKO A., SLAVICH A...... 87 EXPERIENCE OF PLANT-BASED GEL IN TREATMENT OF CHRONIC CATARRHAL GINGIVITIS ...... 87 KRYVENKO L...... 89

396

ISIC-2016 Abstract book COMPARATIVE CHARACTERISTIC OF PERIODONTAL AND ORAL HYGIENE STATUS IN CHILDREN WITH ALLERGIC DISEASES ...... 89 PAVLOVA K...... 90 THE POSSIBILITIES OF PHONOGRAPHIC METHODS OF RESEARCH OF A CONDITION OF OCCLUSION AND EFFICIENCY OF MASTICATORY PROCESS .... 90 MELYNUK V. S., HORZOV L. F., SABOV A.V...... 91 SOCIAL ASPECTS OF PROVIDING DENTAL CARE IN UZHHOROD CHILDREN ... 91 SLYNKO Y...... 92 INFLUENCE OF LOW PHYSICAL ACTIVITY AT MORPHOFUNCTIONAL STATE IN PERIODONTAL LIGAMENT OF PREGNANT RATS POSTERITY ...... 92 STEBLIANKO A., HUDIK A...... 93 EXPERIENCE OF PHYTOPREPARATIONS FOR TREATMENT OFACUTE ODONTOGENIC PERIOSTITIS...... 93 VOLCHENKO N...... 95 PERIODONTAL TISSUE CONDITION IN 8-YEAR OLD SCHOOLCHILDREN WITH DIFFERENT EDUCATION LOAD ...... 95 VOLKOVA O...... 96 BIOCHEMICAL INDICATORS OF ORAL FLUID OF PATIENTS WITH CARIES AT ACTION OF LECITHIN-CALCIUM COMPLEX ...... 96 VOLOSHAN O...... 97 TREATMENTS FEATURES OF PATIENTS WITH ODONTOGENIC MAXILLARY SINUSITIS OF FUNGAL ORIGIN ...... 97 YAKOVLEVA D. U...... 98 MAXILLO-FACIAL SCHWANNOMAS: CLINIC, DIAGNOSTIC AND TREATMENT 98 RESEARCH ADVISOR: СANDIDATE OF MEDICAL SCIENCES RAK A. V...... 98 YAROVENKO L...... 99 SOCIOLOGICAL SURVEU OF THE STUDENTS WITH THE PROGNATHIC OCCLUSION OF THE CITY LVIV ...... 99 YELISEYEVA O...... 101 ORAL CAVITY IMMUNITY CHARACTERISTICS IN THE PATIENTS ORAL LICHEN PLANUS...... 101 ZAAROUR A., RABIH S...... 102 ESTIMATION OF ARTICULATION OF ORGANS OF HUMAN SPEECH SYSTEM IN A DIRECTION OF EXTENDS THE POSSIBILITY OF INDIVIDUAL CORRECTION OF TREATMENT AND PREVENTIVE MEASURES IN PEDIATRIC DENTISTRY ...... 102 МIKULINSKA – RUDICH Y.N., MYS V.O...... 103

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ISIC-2016 Abstract book EXPIRIENCE IN THE USE OF FLOWABLE COMPOSITES FILTEK BULK FILL AND SDR FOR SEALING OF UPPER MOLARS ...... 103 INFECTIOUS DISEASES ...... 104

ADEYEMI A.A., BONDARENKO A.V...... 105 DIAGNOSTIC APPROACHES IN TICK-BORNE DISEASES ...... 105 АNTSYFEROVA N., SOLMENNYK A., BONDAR А., SOKHAN A., ...... 106 PENKOV D, PERELOMOV V...... 106 MODERN UNDERSTANDING OF THE CLINICAL PICTURE THE OF CHRONIC HCV-INFECTION ...... 106 AUGUSTO MAURELIO VICENTE ...... 107 ZIKA VIRUS, DENGUE AND CHIKUNGUNYA IN BRAZIL: SYMPTOMS, DIAGNOSIS ...... 107 DUDNIK A.Y., MOHYLENETS O.I...... 108 CASE OF PLASMODIUM OVALE MALARIA WITH LONG INCUBATION PERIOD ...... 108 ELKOSH MOHAMED MONEIR ...... 110 STUDY OF ANTIBACTERIAL ACTIVITY OF COMBINATIONS OF TEA TREE ESSENTIAL OIL WITH ANTIBIOTICS AGAINST OPPORTUNISTIC MICROORGANISMS IN VITRO ...... 110 FATIANOVA F., VINOKUROVA O...... 111 THE DYNAMICS OF INDEXES OF LIPID METABOLISM FOR THE TREATMENT PATIENTS WITH ACUTE HEPATITIS B ...... 111 GHOSH SOMDIPA ...... 112 CLINICAL PRESENTATION OF TB AMONG PATIENTS WHO HAVE RISK FACTORS OF TB ...... 112 GUZ ELENA, AL BHADILI LAITH MOUSEN, MABROAD AWS FALAH ...... 114 CLINICAL SIGNIFICANCE OF PROSTAGLANDINS IN FORM OF COURSES OF BACTERIAL INTESTINAL INFECTIONS IN CHILDREN...... 114 ILYUKHA S., PARKHOMENKO J...... 115 THYROID STATE IN CASES OF PULMONARY TUBERCULOSIS ...... 115 K.V. IURKO, A.O. SOLOMENNIK, N.I. KHRYSTENKO ...... 116 THE FEATURES OF LIPID METABOLISM IN PATIENTS WITH CHRONIC HEPATITS C...... 116 EGWAKHIDE ADAMS, ZAINAB AKANNI, SOROKINA OLGA ...... 117 A CURRENT REVIEW OF EBOLA HEMORRHAGIC FEVER ...... 117 ELIZABETH EJAGWULU, FATIMA ABDUR-RAHMAN, AL-BHADILI LAITH-MUHSEN ...... 118 398

ISIC-2016 Abstract book RABIES ...... 118 OBI CHIOMA ANNASTASIA ...... 119 HELICOBACTER PYLORY ERADICATION IN TREATMENT OF PATIENTS WITH ACUTE CENTRAL SEROUS CHORIORETINOPATHY ...... 119 OGBU ODIRA .F ...... 120 CHIKUNGUNYA FEVER AND WHY IT SPREADS FASTER THAN OTHER VIRUSES...... 120 OGUNYEMI OPEYEMI OLUWAFUNMILAYO ...... 122 INVESTIGATION OF INCREASING INCIDENCE OF EXTRAPULMONARY TB IN NIGERIA ...... 122 OLKHOVSKYY EVGEN, AL-KARAWI AHMED SHAKIR ...... 123 EPSTEIN-BARR VIRUS INFECTION IN CHILDREN: A RETROSPECTIVE ANALYSIS ...... 123 OMAKAGU EMMANUEL, ANDREW TRIZHELIK AGNES ...... 125 ZIKA VIRUS DISEASE ...... 125 ONUCHUKWU CHIBUZOR, BURTOV DMYTRO, ...... 126 CHARACTERISTICS OF MULTIDRUG-RESISTANT TUBERCULOSIS IN NIGERIA ...... 126 PATEL PRIYANKA HARISHCHANDRA, ISA MASHKUR ABDULHAMID ...... 127 THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL AGE CHILDREN WITH SEVERE ASTHMA...... 127 POPOVICH N...... 128 CONTEMPORARY ASSESSEMENT OF ENTEROSORBENTS ...... 128 SERDIUK V. KOZLOVА K...... 130 COMPARAIVE CHARACTERISTICS OF DIFFEREN GENERAIONS OF CEPHALOSPORINS AT TREATMENT OF TONSILLITIS ...... 130 SHCHERBICH J.V...... 132 EXTERNAL TREATMENT OF LIGHT COURSE OF ACNE DISEASE IN THE ACUTE STAGE ...... 132 SOKHAN A.V., GVOZDECKAYA M.G., URKO K.V., GAVRILOV A.V., HASANOVA A...... 133 CLINICAL AND LABORATORY FEATURES OF ACUTE NEUROINFECTIONS IN HIV-POSITIVE PATIENTS...... 133 SOKHAN A.V., ANSYFEROVA N.V., GAVRILOV A.V., DUDNIK A.U...... 134 DIAGNOSTIC VALUE OF NEURON SPECIFIC ENOLASE (NSE) LEVEL IN CEREBROSPINAL FLUID OF PATIENTS WITH ACUTE BACTERIAL MENINGITIS...... 134 ELZAHRA MOHAMED ...... 135 399

ISIC-2016 Abstract book STIGMATIZING INFECTIOUS DISEASES ...... 135 TIKHONOVA OLGA, ADAMSKY MARK ...... 136 CLINICAL CRITERIA FOR DIAGNOSIS OF CEREBRAL TOXOPLASMOSIS IN HIV- INFECTED PATIENTS ...... 136 TREGUB E...... 137 CHANGES IN NITROGEN OXIDE IN PATIENTS WITH DESTRUCTIVE RECURRENT PULMONARY TUBERCULOSIS UNDERGOING THE INTENSIVE PHASE OF ANTI-TUBERCULOSIS THERAPY ...... 137 VASHCHENKO V. N., KULINCHENKO G. M., LUCHKO N.O...... 138 SUPERSHARP COURSE OF FULMINANT HEPATITIS B. CLINICAL CASE...... 138 NEUROSCIENCES ...... 141

ALI HARB ...... 142 PARKINSON’S DISEASE, AND ITS RELATION WITH THC (TETRAHYDROCANNABINOL) ...... 142 FELDMAN D.A., MYKHAYLOV V.B...... 143 PSYCHO-EMOTIONAL DISORDERS IN DISPLACED RESIDENTS FROM ATO ZONE ...... 143 GHAZAL BILAL HASSAN ...... 144 EFFECT OF POST-ISOMETRIC THERAPY ON PATIENT WITH TENSION HEADACHE ...... 144 HLEIZER A...... 145 IMPACT OF GILLES DE LA TOURETTE SYNDROME ON THE INTELLECTUAL LEVEL OF THE CHILDREN ...... 145 KASHYRINA O., RIZNYCHENKO O...... 146 EFFECTIVENESS OF ZINC PREPARATIONS IN TREATMENT OF HEPATOLENTICULAR DEGENERATION ...... 146 KENNEDY ENEM ...... 147 TRIGGERS OF MIGRAINE IN DIFFERENT PATIENTS AND CONDITIONS ...... 147 KOROLKOVA A...... 147 THE PROBLEM OF EARLY DIAGNOSTICS OF FRIEDREICH'S ATAXIA ...... 147 KRASKOVSKA Т...... 149 PSYCHOEDUCATION AS ONE OF THE COMPONENTS OF RESOCIALIZATION IN PATIENTS WITH DEPRESSION ...... 149 EFFECTS OF PLASMAPHERESIS AND PHYSICAL EXERCISE ON A PATIENT WITH MULTIPLE SCLEROSIS...... 150 OBI CHIOMA ANNASTASIA ...... 151 400

ISIC-2016 Abstract book ROLE OF AGE AND SEX DIFFERENCE IN ATHLETES WITH CONCUSSION ...... 151 OLANIYAN MERCY ...... 152 THE USE OF MUSIC THERAPY IN THE TREATMENT OF ANXIETY AND DEPRESSIVE DISORDERS IN PREGNANT WOMEN ...... 152 OLEFIR O.S...... 153 COMPUTER ADDICTION AS A FACTOR OF PROVOKE SITUATIONAL ANXIETY INCREASING ...... 153 PLYEKHOVA O.O., KALYUZHKAV.YU...... 155 THE LEVEL OF SOCIAL MALADJUSTMENT AND ANXIETY OF MODERN STUDENTS IN DEPENDING ON LOCATION OF LEARNING ...... 155 POLIKOV G...... 156 QUALITY OF LIFE OF PATIENTS WITH NEUROSURGICAL DISEASES ...... 156 PRAHARAJ POOJA, NEKRASOVA NATALIYA ...... 157 SPONDYLOGENIC INFLUENCE ON VERTEBRAL ARTERIES IN VERTEBROBASILAR INSUFFICIENCY...... 157 TIKHONOVA OLGA, KOPYTKO MARINA ...... 159 IMPROVING THE QUALITY OF LIFE IN PATIENTS WITH COMBINED CRANIO- MAXILLO-FACIAL TRAUMA ...... 159 ULYANOVSKА M...... 160 ANALYSIS OF MEDICAL UNIVERSITY STUDENTS` COMPETENCY IN THE PROBLEM OF EPILEPSY...... 160 ZAHORA O...... 161 INFLUENCE OF CENTRALLY ACTING MUSCLE RELAXANTS TO THE MUSCLE SPASM IN POST-STROKE PERIOD ...... 161 ZELENSKA K.O...... 162 ANALYSIS OF STRESSFUL SITUATIONS THAT LEAD TO DEVELOPMENT OF AUTO-AGGRESSIVE BEHAVIOR IN PATIENTS WITH DEPRESSIVE DISORDERS ...... 162 KOROVINA L. D., KONDRATENKO A. P...... 163 THE COMPONENTS OF THE DYNAMICS OF BODY WEIGHT IN PATIENTS WITH PARANOID SCHIZOPHRENIA...... 163 HMAIN S., KOZHINA H.M...... 164 INFLUENCE OF ART THERAPY IN COMPLEX TREATMENT ON THE QUALITY OF REMISSION IN PATIENTS WITH RECURRENT DEPRESSIVE DISORDER ...... 164

401

ISIC-2016 Abstract book OBSTETRICS AND GYNECOLOGY ...... 165

ALAYA LAMIA ...... 166 MOLECULAR BIOLOGICAL FACTORS OF GENITAL PROLAPSE IN PERIMENOPAUSAL WOMEN WITH CONNECTIVE TISSUE DYSPLASIA AND THEIR CORRECTION ...... 166 P. A. ALIEVA, S. E. MALIKOVA, I.V.ZHUK ...... 167 IMPROVEMENT OF TREATMENT EFFICIENCY IN CHRONIC INFLAMMATORY DISEASES OF UTERINE ADNEXA ...... 167 ARSENTYEVA ALINA ...... 168 CURRENT METHODS OF CERVICAL PREGNANCY DIAGNOSIS ...... 168 BLAGOVESHCHENSKIY R., REZNIK M. A., RAKITYANSKIY I. YU., RUBINSKAYA A. N...... 169 HERPES VIRUS INFECTION INFLUENCE ON INTRAUTERINE STATE OF THE FETUS ...... 169 BORODAI I., MOLCHANIUK D., PONOMARENKO T...... 171 VIRUS AGENTS AS FACTORS OF HABITUAL MISCARRIAGE ...... 171 CHERNIAKOVA A.E., KARMAZINA I.S...... 172 ROLE OF CERVICAL CANAL SCREENING IN DIAGNOSTICS AND THERAPY OF CERVIX UTERI PATHOLOGY ...... 172 CHERNOVA I.G, NAUMOVA E.N...... 173 ADENOMYOSIS TREATMENT IN WOMEN OF REPRODUCTIVE AGE ...... 173 DOUGLAS B. I., ALABO Y. J...... 175 ABORTION’S AFTERMATH. WHAT IS ABORTION? ...... 175 DYNNIK OLEKSANDRA, NEBESNA HANNA ...... 176 FEATURES OF SONOGRAPHIC INDICES OF THE SMALL PELVIS ORGANS IN GIRLS WITH ABNORMAL UTERINE BLEEDING ...... 176 FEDZIUKOVA L...... 177 SURGICAL DELIVERY IN MODERN OBSTETRICS ...... 177 O. V. GNATENKO, S. V. KEBASHVILI ...... 178 CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF ADNEXAL TORSION IN CHILDREN AND ADOLESCENTS ...... 178 O. V. GNATENKO, S. V. KEBASHVILI ...... 179 CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF ADNEXAL TORSION IN CHILDREN AND ADOLESCENTS ...... 179 HASAN A...... 180

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ISIC-2016 Abstract book ROLE OF THE METHODS OF OVUM EXTRUSION IN THE PREVENTION OF SECONDARY TUBOPERITONEAL INFERTILITY DURING ECTOPIC PREGNANCY TREATMENT ...... 180 P. A. ALIEVA, S. E. MALIKOVA, S.S. FILATOVA, T. A. IVANOVA ...... 181 IMPROVEMENT OF TREATMENT EFFICIENCY IN CHRONIC INFLAMMATORY DISEASES OF UTERINE ADNEXA ...... 181 JACOBS Y., ROMANENKO A.A...... 182 PRIMARY CESAREAN DELIVERY INCREASES RISK IN THE NEXT PREGNANCY ...... 182 KAMBINDA DRICKY NASILELE ...... 183 GESTATIONAL DIABETES AND MEDICAL TREATMENT ...... 183 KLUIUNYK M.V., KOLGANOVA N.L...... 184 SPECIFIC DERMATOSES OF PREGNANT WOMEN ...... 184 KONOVAL A...... 186 THE IMPACT OF IMMUNOMODULATORY THERAPY ON THE MICROBIAL ASSOCIATIONS IN WOMEN WITH CSO ...... 186 LITVINOVA A...... 187 FEATURES OF PREGNANCY COMPLICATED BY PREECLAMPSIA AND ANTIPHOSPHOLIPID SYNDROME ...... 187 MIROSHNICHENKO Y.N., TVEREZOVSKAYA I.I...... 189 APPLICATION OF LETROZOLE IN ENDOCRINE STERILITY TREATMENT ...... 189 ALISA NAGIEVA ...... 190 MODERN APPROACHES TO THE ISSUES OF IMMUNOLOGICAL INFERTILITY DIAGNOSTIC ...... 190 NESTERUK A.V...... 191 CYTOKINE PROFILE AS DIAGNOSTIC CRITERION IN PERINATOLOGY ...... 191 NOVIKOVA ANASTASIA ...... 192 CLINICAL AND ETIOLOGIC CHARACTERISTICS OF ABNORMAL UTERINE BLEEDINGS IN ADOLESCENT GIRLS ...... 192 O. V. GNATENKO, A. M. PROKOPENKO ...... 193 IMPROVEMENT OF DIAGNOSIS AND TREATMENT EFFICIENCY IN ACUTE ABDOMEN IN YOUNG FEMALE PATIENTS AND ADOLESCENT GIRLS ...... 193 OBINYAN OFURE ABIGAEL ...... 195 C-JUN INFLAMMATORZ PROTEIN; A NEW DIAGNOSTIC APPROACH TO THE DIAGNOSIS OF ENDOMETRIOSIS ...... 195 OLUWAYEMI M., GRADIL O.G...... 196 THE NEW ASPECTS OF ENDOMETRIAL CANCER TREATMENT ...... 196 403

ISIC-2016 Abstract book I.K.OSOVSKIY, R. E. BLAGOVESHCHENSKY, L. A. GREBENYUK ...... 197 ADMINISTRATION OF OCTAPLEX IN COMPREHENSIVE TREATMENT OF PATIENTS WITH PROFUSE OBSTETRICAL HEMORRHAGE ...... 197 PRAHARAJ POOJA ...... 198 RELEVANT AND MOST APPROPRIATE CONCEIVING PERIOD FOR A FULL TERM PREGNANCY AFTER MISCARRIAGE ...... 198 SHAKHZADIAN LAURITTA, LIUBOMUDROVA KATERINA ...... 199 CRITERIA FOR THE DIAGNOSIS OF SERTOLI - LEYDIG TUMORS...... 199 SKORBACH OLENA, KUCHER ALINA...... 200 METABOLIC IMPLICATIONS IN WOMEN AFTER HYSTERECTOMY ...... 200 SOE THUREIN, ROMANENKO A., ADEYEMI A...... 202 ROLE OF SFLT-1/PLGF RATIO IN THE DIAGNOSIS AND PROGNOSIS OF PREECLAMPSIA ...... 202 V. YU. SOLYANIK, A. M. CHUMAK ...... 203 CERVICAL POLYP (CLINICAL CASE) ...... 203 V. A. SOROKINA, V. V. GRIGORYEVA, A. K. DUSMATOVA ...... 204 INCIDENCE AND CHARACTER OF INFLAMMATORY DISEASES IN PREGNANT WOMEN ...... 204 N. A. STOLBOVA ...... 205 ENDOMETRIAL HYPERPLASIA. TREATMENT AND PREVENTION AT REPRODUCTIVE AGE...... 205 YU. A. SVIDCHENKO, E. A. KAMARDINA, V. A. MIROSHNIKOVA ...... 207 PROLONGED CONTRACEPTION STRATEGIES IN THE TREATMENT OF GENITAL ENDOMETRIOSIS ...... 207 ADEJOBI FISAYO, NWAIZU TOCHUKWU, NAGUTA L.A...... 208 EFFECT OF PHYTOESTROGENS IN PATIENTS WITH ABNORMAL UTERINE BLEEDING...... 208 TYKHANSKYI D., LIUBOMUDROVA K.S., MELASHYCH JANE ...... 209 TREАTMENT OF BACTERIAL VAGINOSIS WITH MONOCHROMATIC RED LIGHT RESEARCH ADVISOR - ASSOCIATE PROFESSOR GAYVORONSKAYA S. DEPARTMENT OF OBSTETRICS AND GYNECOLOGY NO. 2, ...... 209 YAVDAK ANASTASIA ...... 210 SPECIFIC FEATURES OF UTERINE SCAR FORMATION AFTER CESAREAN SECTION ...... 210

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ISIC-2016 Abstract book PEDIATRICS ...... 212

ASUKA EMEDIONG S, ALIEJIM UCHENNA S...... 213 INDICES OF IMMUNE SYSTEM OF JUVENILE IDIOPATHIC ARTHRITIS PATIENTS WITH DIFFERENT COMBINATIONS OF GENOTYPES OF METHYLENETETRAHYDROFOLATE REDUCTASE, METHYLTRANSFERASE, METHYLTRANSFERASE REDUCTASE...... 213 AWOFOLAJU T.T., ADELEKE A...... 214 LABORATORY BLOOD PARAMETERS OF JUVENILE IDIOPATHIC ARTHRITIS PATIENTS WITH DIFFERENT COMBINATIONS OF GENOTYPES OF METHYLENETETRAHYDROFOLATE REDUCTASE, METHIONINE SYNTHASE, METHIONINE SYNTHASE AND REDUCTASE GENES ...... 214 MOUSA KHALIL BAHJA, ZEINAB HAMMOUND ...... 215 RISK FACTORS IN MAXILLARY SINUSITIS ESTIMATED BY CONE BEAM COMPUTED TOMOGRAPHY ...... 215 CHERNENKO L.N...... 217 STATE OF THE LEFT VENTRICULAR FUNCTION IN CHILDREN WITH BRONCHOPULMONARY DYSPLASIA RESEARCH ADVISOR – PROFESSOR GONCHAR M...... 217 DRYL I., MECHANINA D...... 218 FEATURES OF MICROBIAL-INFLAMMATORY DISEASES IN INFANT CHILDREN ...... 218 DRYL I., KAZARYAN V., MEDYK E...... 219 FEATURES OF MICROBIAL-INFLAMMATORY DISEASES IN INFANT CHILDREN ...... 219 GORDYEYEVA A.A., PLOHINOV G.A., ZABOLOTNAYA N.I...... 220 CHEST WALL DEFORMATION AS ONE OF MANIFESTATIONS OF CONNECTIVE TISSUE DYSPLASIA ...... 220 GUPTA ANMOL ...... 221 BREASTFEEDING IN KHARKIV, CAN WE IMPROVE SITUATION? ...... 221 ISA MASHKUR ABDULHAMID, PATEL PRIYANKA HARISHCHANKA, ...... 223 ULIANA IVANIVNA MARUSYK ...... 223 THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL-AGE CHILDREN WITH SEVERE ASTHMA...... 223 KOVAL V...... 224 DIFFERENTIAL DIAGNOSIS OF TROMBOCYTOSIS IN CHILDREN BASED ON CLINICAL EXPERIENCE ...... 224

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ISIC-2016 Abstract book KOVAL V.A., KOLESNIK V.O., OMELCHENKO A.V...... 225 PEDIATRIC SPINAL MUSCULAR ATROPHY AS A SYNDROME OF FLACCID CHILD ...... 225 ABOGHEDEH A.M., ABUGHADEH A.R., ASIBEY A.G., ...... 227 SHUAIBAT M.A., LUPALTSOVA O.S...... 227 THE CELL IMMUNITY COMPONENT IN CHILDREN WITH REACTIVE LYMPHADENOPATHY ...... 227 LYSAK MARYNA, KYSIL IRINA ...... 228 SPECIFICS OF AUTONOMIC REGULATION OF TEENAGER'S ORGANISM: MEDICAL AND SOCIAL PROBLEMS...... 228 MUZHANOVSKYI V., MALICH A., LYSYTSKA N...... 229 APERT SYNDROME OF NEWBORN ...... 229 NAGIEVA K. F...... 230 COMBINATION OF HEREDITARY MOTOSENSOR NEUROPATHY WITH HYPERHOMOCYSTEINEMIA AND FOLATEDEFICIENCY ...... 230 ONWUJEKWE UDODI ...... 231 HAEMATOLOGICAL MANIFESTATIONS OF HELMINTHIASIS IN CHILDREN .. 231 PLIUSHKO D., LIEVASHOVA A., YANOVSKAYA A...... 232 THE CLINICAL CASE OF THE COMBINATION OF PROGRESSIVE BECKER MUSCULAR DYSTROPHY, MITOCHONDRIAL DYSFUNCTION AND SECONDARY REACTIVE HEPATITIS ...... 232 E.PODGALAYA, T.TESLENKO, A.SENATOROVA ...... 233 FEATURES OF CONDITION OF CARDIOVASCULAR SYSTEM IN NEWBORNS WITH DIABETIC FETOPATHY ...... 233 POPOVA T. O...... 234 FEATURES OF CARDIOVASCULAR RISK IN CHILDREN WITH BRONCHIAL ASTHMA ...... 234 POTIKHENSKA K...... 236 TRAUMATIC LEUKEMIA MASKS IN CHILDREN ...... 236 ISA MASHKUR ABDULHAMID, PATEL PRIYANKA HARISHCHANDRA, ULIANA IVANIVNA MARUSYK ...... 237 THE MARKERS OF ATOPIC REACTIVITY IN SCHOOL-AGE CHILDREN WITH SEVERE ASTHMA...... 237 RUD VIKTORIA ...... 238 EARLY SYMPTOMS OF ACUTE LEUKEMIA IN CHILDREN ...... 238 SEMENYUK M, KYSLOV O.V, PAKHOMOVA A.V...... 239 REFRACTIVE TYPES IN PATIENTS WITH CONNECTIVE TISSUE DYSPLASIA . 239 406

ISIC-2016 Abstract book SHAKHZADIAN LAURITTA ...... 240 SUBCORTICAL - CEREBELLAR DEGENERATION ...... 240 STRELKOVA M., SILICHEVA A...... 241 THE RISK FACTORS OF THE DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN CHILDREN WITH GASTROENTEROLOGICAL DISEASES ...... 241 TIMOSHENKO MAXIM, KUBEEV ERBOL ...... 243 SYSTEM FOR MONITORING THE STATE OF HEALTH OF CHILDREN AS A TOOL FOR IMPROVEMENT OUTPATIENT SERVICE (FOR EXAMPLE KENTAU)...... 243 TIWARI PAWAN KUMAR, OYEBAMIRE MUSSA ABIMBOLA ...... 244 INNOVATIVE BIO-TECHNOLOGICAL DEVELOPMENTS OF UKRAINIAN SCIENTISTS IN THE AREA OF PROBIOTICS ...... 244 TKACHUK LJUBOV', DEONEGA ANNA, URYVAEV ANDREY ...... 245 ANTIPHOSPHOLIPID SYNDROME. CASE STUDY...... 245 YANOVSKA K., MOSKALENKO V., TERESHCHENKO S...... 246 MICROBIOLOGICAL STATUS OF THE CHILDREN WITH CYSTIC FIBROSIS IN KHARKIV REGION 246 PREVENTIVE MEDICINE ...... 248

ADEYEMI А.А...... 249 THE EFFECTS OF SOME ENVIRONMENTAL FACTORS ON THE REPRODUCTIVE SYSTEM...... 249 ALALE MUMUNI ANASS, SIBAMBA MUTELO FAITH ...... 250 INFLUENCE OF EMOTIONAL AND VOLUTIONAL SPHERE ON THE STUDENT’S EDUCATIONAL ACTIVITY ...... 250 ANDREW BRIAN AMOAH-DANFUL, REZNICHENKO O.G., GRYGORIAN O.V...... 251 PSYCHOLOGICAL EFFECTS OF SOCIAL MEDIA ...... 251 ANTONOVICH SVETLANA ...... 252 SOME PROBLEMS OF SOCIAL AND PSYCHOLOGICAL ADAPTATION OF THE VISUALLY IMPAIRED DISABLED PEOPLE ...... 252 BOGACHOVA O.S., MENSAH SETH OMARI, SKIBO O.YU...... 254 RISK FACTORS OF AGRICULTURE IN GHANA ...... 254 DZIUBA. V...... 255 PATHOGENIC PROPERTIES OF EDIBLE MUSHROOMS ...... 255 ELKOSH MOHAMED MONEIR ...... 256 STUDY OF ANTIBACTERIAL ACTIVITY OF COMBINATIONS OF TEA TREE ESSENTIAL OIL WITH ANTIBIOTICS AGAINST OPPORTUNISTIC MICROORGANISMS IN VITRO ...... 256 LITVINENKO A...... 257 407

ISIC-2016 Abstract book POLLUTION OF DRINKING WATER WITH HEAVY METALS SALTS AND REMOVING THEM FROM SOLUTIONS BY MEANS OF NANOCOMPOSITE ZIRCONIUM (ΙV) OXIDE ...... 257 MEDYANIK E.A., BOYARSKIY O.O...... 259 ANALYSIS OF THE IMPACT OF EXOGENOUS FACTORS ON INDICATORS OF KHARKIV NATIONAL MEDICAL UNIVERSITY STUDENT’S HEALTH ...... 259 MOHAMAD SULTAN, ENEMEGENE ESEROGENE, KATELEVSKAYA N.M...... 260 PREVENTION OF STRESS DISORDERS OF STUDENTS IN MEDICAL UNIVERSITY ...... 260 NLEND MICHEL PHARRELL, OLAMAEKUGBE B., KATELEVSKAYA N.M...... 261 RISK FACTORS OF TEEN SUICIDE AS PSYCHO-HYGIENIC PROBLEM ...... 261 OBINYAN OFURE ABIGAEL ...... 262 SCHISTOSOMIASIS EPIDEMIC IN NIGERIA ...... 262 OTAIGBE P.A., GOODLITE S.N...... 263 PSYCHOHYGIENIC ASPECTS OF TEST ANXIETY AT MEDICAL STUDENTS ...... 263 VLADISLAVA SARKIS-IVANOVA, ANDREY SOKOLTSOV, YEGOR BUZEVICH ...... 264 ANTIBIOTIC RESISTANCE OF PSEUDOMONAS AERUGINOSA STRAINS AS A CRITERION OF ASSESSMENT PUBLIC HEALTH REGIMEN OF MEDICAL PREVENTIVE INSTITUTIONS ...... 264 SINGH SHIVAM, VASAVA PRASHANT ...... 266 PSYCHOLOGY AS A MEDICAL INSTRUMENT IN STRUGGLING WITH DEPRESSION ...... 266 TINUOLA OLAJIDE, ANDIKAN UDOH EFFIONG, OLGA S. SASINA ...... 267 PSYCHO-HYGIENIC HEALTH RISK FACTORS OF CHILDREN AND TEENAGERS WITH VISION PATHOLOGY ...... 267 SURGERY ...... 269

AHMED R.B...... 270 DIFFERENT MANAGEMENT APPROACHESFOR PATIENTS WITH PANCREATIC TRAUMA ...... 270 D.YU ARTEMCHUCK, SCIENTIFIC DIRECTOR PH.D. V.YU. SHAPOVALOV LAPAROSCOPY IN DIAGNOSIS OF ACUTE APPENDICITIS ...... 271 BASYLAISHVILI S...... 272 MORPHOLOGICAL EVALUATION OF NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH LUNG CANCER ...... 272 BILCHENKO SOFIIA CORNEAL CHANGES AFTER THE NON PENETRAITING DEEP SCLERECTOMY AMONG PATIENTS WITH GLAUCOMA AND DIABETIC 408

ISIC-2016 Abstract book POLYNEUROPATHY KHARKIV NATIONAL MEDICAL UNIVERSITY OPHTHALMOLOGICAL DEPARTMENT SCIENTIFIC SUPERVISOR: ZAVOLOKA OLESYA ...... 273 BOHDANETS O., IVACHNOVA K., NOVIKOVA K...... 274 THE CONTENT OF FAS LIGAND IN PRIMARY OPEN ANGLE GLAUCOMA ...... 274 BORACHOK T., KOPANSKA D...... 275 IMPACT OF PREOPERATIVE FASTING TIMES ON BLOOD GLUCOSE, KETONE BODIES AND ACID-BASE BALANCE IN CHILDREN YOUNGER THAN 36 MONTH ...... 275 BOYARSKIY A.A...... 276 THE ASSESSMENT OF THE EFFICIENCY OF USING THE TRAM-FLAP ON THE NUTRIENT PEDICLE AS THE BREAST RECONSTRUCTION METHOD ...... 276 DAVYDYCH ALINA ...... 277 PATHOGENETIC ASPECTS OF DRY EYE SYNDROME IN SJOGREN'S DISEASE 277 DURAS ANASTASIA, BARANIUK MARIIA ULTRASOUND BIOMICROSCOPIC FEATURES OF PIGMENTARY GLAUCOMA ...... 279 DURAS ANASTASIA, AKSJONOVA NADIIA CHANGES IN THE ANTERIOR CHAMDER AFTER PHACOEMULSIFICATION CATARACT ...... 280 ELENA FUNDOVNA, ILYINA YEVGENIYA ...... 281 COMPARATIVE CHARACTERISTICS OF THE EFFECTOF LUMINESCENT AND LEDLIGHT ON THE ORGAN OF VISION ...... 281 GALKINA KARETYNA, SAMOILENKO SVETLANA, NIKOLAENKO ALINA ...... 282 THE EFFECTS OF PHYSICAL ACTIVITIES ON THE GLYCEMIA LEVELS OF CHILDREN WITH THE DIABETES MELLITUS ...... 282 GILLIES N.P...... 283 MANAGEMENT OF PREMATURE EJACULATION CONCERNED WITH COMPARISONS OF PHARMACEUTICAL AND THERAPEUTIC MANAGEMENT VERSUS SURGICAL INTERVENTION ...... 283 MIASOIEDOV K.V...... 284 APPLICATION OF THE HYDRAULIC DESOBLITERATION IN TREATMENT OF PATIENTS WITH CRITICAL LIMB ISCHEMIA ...... 284 N.M. GONCHAROVA ...... 285 MINI-INVASIVE SURGICAL TREATMENT OF COMPLICATED PSEUDOCYST OF PANCREAS SECOND TYPE ...... 285 IEVTUSHENKO D., IEVTUSHENKO A.,VINOGRADOV B., BELOUSOVA M...... 286 ACUTE CHOLANGITIS IN PATIENTS WITH CHOLELITHIASIS ...... 286 ILYUKHA SERGEY, MITROFANYK VALERIYA, BOGUN MARINA ...... 287 ALLOPLASTY OF VENTRAL HERNIAS...... 287 409

ISIC-2016 Abstract book IVAKHNOVA K. BOGDANETS O., NOVIKOVA K...... 288 CONTENTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR FOR PRIMARY OPEN-ANGLE GLAUCOMA ...... 288 AMRITPAL SINGH KHANGURA ...... 289 TROPHIC LEG ULCERS...... 289 KHODAK A.S...... 290 THE CASE OF PRIMARY – PLURAL MALIGNANT TUMORS OF FOUR LOCALIZATION ...... 290 KHVOROSTINKO RUSLAN ...... 291 THE OPTIMIZATION OF TREATMENT OF THE RETINOPATHY OF PREMATURITY ...... 291 KRUGLYAK V...... 292 TREATMENT OPTIMIZATION OF DELAY EJACULATION ...... 292 KRUGLYAK V...... 293 TREATMENT OPTIMIZATION OF DELAY EJACULATION ...... 293 NAHORNA D., YAKOVENKO V...... 295 ENDOSCOPY DISSECTION OF SMALL STROMAL TUMORS OF THE UPPER GASTROINTESTINAL TRACT...... 295 OLANIYAN M.M., KASIEV S...... 296 IMPROVEMENT OF THE SEXUAL FUNCTION OF PATIENTS WITH VENO- OCCLUSIVE ERECTILE DYSFUNCTION AND BILATERAL VARICOCELE ...... 296 OLEFIR O., ZAMYATIN D...... 297 HEART AND PERICARDIUM DIAGNOSTIC FEATURES DURING MINE-BLAST TRAUMA ...... 297 ONUCHUKWU CHIBUZOR VICTOR, GAVURA M...... 298 EFFICACY AND SAFETY OF SURGICAL TREATMENT OF THE VITREOMACULAR TRACTIONAL SYNDROME ...... 298 PAZHIN S.O., PONOMAREVA K.V., MINUHIN D.V., LOZHKO N.V...... 299 ROENTGEN-ENDOVASCULAR METHODS OF HEMOSTASIS IN PATIENTS WITH PULMONARY HAEMORRHAGE ...... 299 PETIUNIN PAVLO; PETIUNINA VICTORIYA; PETIUNIN OLEXIJ ...... 300 A NEW NONINVASIVE TECHNIQUE FOR EVALUATION OF ACUTE-ON-CHRONIC LIVER FAILURE IN THE CIRRHOTIC PATIENTS...... 300 PETRYCHENKO I.I...... 302 DILATED PUNCTURE TRACHEOTOMY ...... 302 PRYKHODKO D.О., ARUSTAMOVA G.S., KHATSENKO I.O...... 303

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ISIC-2016 Abstract book CLINICAL FEATURES OF EXPERIMENTAL MODELS OF OCULAR HYPERTENSION AND GLAUCOMA ...... 303 RIZNYCHENKO A.N...... 304 ANALYSIS OF FEATURES GUNSHOT BONES WOUNDS ...... 304 ROBAK VSEVOLOD, KURBATOV VADYM, DRANA LYDMYLA ...... 305 THE CHOICE OF OPERATIVE ACCESS IN PATIENTS WITH ACUTE NECROTIC PANCREATITIS ...... 305 SALAWU K.T...... 306 ROLE OF DIFFERENT PARTS OF THE DUODENUM IN THE SEVERITY OF DUODENAL TRAUMA ...... 306 IVZHENKO L., SHEREMETA I...... 307 THE NATURE OF CHANGES IN MEIBOMIAN GLANDS IN PATIENTS WITH DIABETIC POLYNEUROPATHY ...... 307 SHIRGBA SONTER SONTE' JACOB ...... 309 AORTIC ANEURYSMS (ABDOMINAL AORTIC ANEURYSM) ...... 309 SYKYKH V.I., PORADIUK K.V...... 310 PLASMOTHERAPY AS AN ADDITIONAL THERAPEUTIC METHOD IN SURGICAL AND NON-SURGICAL THERAPY OF CRITICAL LIMB ISCHEMIA PATIENTS ..... 310 TREGUB YEVHENII ...... 311 USING OF LAPAROSCOPIC TECHNOLOGIES IN TREATMENT OF PERFORATIVE GASTRODUODENAL ULCERS ...... 311 TROFIMOV MIHAIL ANDREEVICH ...... 312 DIAGNOSICS AND TREATMENT OF BACTERIAL LIVER ABSCESSES ...... 312 TSOPOZIDIS CHRISTOS, BORISENKO ANASTASIA, TELEZHNYI ANDRII ...... 314 CLINICAL CASE: SOMATOPSYCHIC DISORDER IN A FEMALE PATIENT WITH MULTINODULAR EUTHYROID GOITER ...... 314 VOLIK M...... 315 THE STIMULATION OF PROSTAGLANDINS IN THE TREATMENT OF ERECTILE DYSFUNCTION ...... 315 YAREMKОI.YA., TROFIMOVAA.V., MELNIKOVV.V., SAPAYA.V., TYSHKOO.S...... 316 FEATURES OF RHE LAPAROSCOPIC CHOLECYSTECTOMY IN PATIENTS WITH PNEUMOCONIOSIS ...... 316 ZHELEZNIKOVA M.O...... 318 OUR EXPERIENCE IN DIAGNOSTICS AND TREATMENT OF CHRONIC RENAL TRANSPLANT DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE BASED ON THE STUDY OF POLYOMA VIRUS INFECTION ...... 318 ZHURBA Y. P., GONCHAROVA N.N., KOZHEMYAKA K.O...... 321 411

ISIC-2016 Abstract book MODERN SURGICAL DECOMPRESSION OF BILIARY TRACT OBSTRUCTIVE JAUNDICE ...... 321 ZIENOVIEVA O...... 322 APPLICATION OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR DIABETICS WITH MACULAR EDEMA ...... 322 THERAPY ...... 324

ABUGU NNADOZIE LIVINUS ...... 325 A REVIEW PAPER ON INTRAUTERINE GROWTH RESTRICTION AND IMPLICATIONS ON THE CARDIOVASCULAR SYSTEM ...... 325 ABUGU NNADOZIE LIVINUS, ETUKUDO IME-OBONG ...... 326 NO METABOLISM IN PATIENTS OF ELDERLY AGE WITH CHRONIC HEART FAILURE ...... 326 AHMED RALIAT BALOGUN ...... 327 INDUCTORS OF ENDOGENOUS INTERFERON IN THERAPY OF ECZEMA ...... 327 ALBASHIR AYAT, MOHAMMED AHMED ...... 328 MOST PRONOUNCED PSYCHOLOGICAL SYMPTOMS ASSOCIATED WITH IBS 328 ALHAAD MUSTAFA MOHAMUUD, KNIGAVKO A...... 329 SEXUAL REHABILITATION AFTER DIFFERENT TYPES OF URETHOPLASTY . 329 AL-TRAWNEH O.V...... 331 THE THERAPEUTIC STRATEGY IS A COMBINATION WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS ...... 331 BALATIUK I.A.1, HLADKYKH F.V.2, YAVORSKYI O.M.3, SOKYRKO M.V.2 ...... 332 CLINICAL ASPECTS OF THE TREATMENT OF CHARCOT OSTEOARTHROPATHY ...... 332 BEREZHNIY H.G., SHAPOSHUK V...... 333 MORPHOFUNCTIONAL STATE OF HEART AND CAROTID ARTERIES IN MALES AGED 18-25 YEARS WITH DOCUMENTED HIGH BLOOD PRESSURE ...... 333 BOROVYK K.N., SAIIKA A.I...... 335 THE FEATURES OF THE QUALITY OF LIFE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CONCOMITANT OBESITY ...... 335 BUTOVA IEVGENIIA ...... 336 STATINS APLICATION FOR THE TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS TYPE 2 ...... 336 CHEKHOVSKOY A.O...... 337 EARLY MARKERS OF ATHEROSCLEROSIS MANIFESTATION IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE ...... 337 412

ISIC-2016 Abstract book S.V.DEMIANIUK, O.A.VILTSANIUK, I.M.KOVAL ...... 338 DIAGNOSTIC OF THE LIVER FIBROSIS SEVERITY IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES ACCORDING TO ELASTOMERY RESULTS ...... 338 VINNITSA NATIONAL MEDICAL UNIVERSITY NAMED AFTER M. I. PIROGOV ...... 338 T. M.PRYADKA, S.R. DUTCHAK ...... 339 STATUS OF OXYGENATION AND VENTILATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME ...... 339 DZIUBA V., BURSAK A...... 342 BURNOUT SYNDROME AND ITS CONNECTION WITH HIGH BLOOD PRESSURE ...... 342 FOMINA L.V...... 343 CELLULAR AND HUMORAL IMMUMITY IN PATIENTS WITH ECZEMA ...... 343 KADYKOVA O., SHEIKH SAHER ...... 344 THE RELATIONSHIP BETWEEN ANTHROPOMETRIC AND LIPID PARAMETERS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND OBESITY DEPENDING ON THE GENOTYPE GENE POLYMORPHISM OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (GLU298ASP) ...... 344 KALUZHKA V., MARKEVYCH M...... 345 HORMONAL AND METABOLIC DISORDERS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND TYPE 2 DIABETES ...... 345 KASHTAN KATERYNA ...... 346 THE STUDY OF PHYSICAL ACTIVITY OF CHILDREN WITH TYPE 1 DIABETES USING QUESTIONNAIRE ...... 346 KOPANSKA DZW., BORACHOK T...... 347 ESOPHAGITIS: REALITY TODAY, PRACTICE PATTERNS AND RESULTS ...... 347 KOTELIUKH M.Y., MARTOVYTSKYI D.V...... 348 THE STUDY OF DYNAMICS OF MATRIX METALLOPROTEINASE-13 AND TENASCIN C IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND TYPE 2 DIABETES...... 348 KOTVITSKAYA VALERIA...... 349 ENDOTHELIAL DYSFUNCTION BIOMARKERS IN OBESE PATIENTS WITH ARTERIAL HYPERTENSION ...... 349 O. P. KOZLOV, S. G. MALANCHUK, O. G. SOROKINA, A. O. RADCHENKO ...... 350 IMPACT OF VIOLET, GREEN AND ORANGE SPECTRA LED RADIATION ON LECITHINASE AND DNASE ACTIVITY OF S. AUREUS AND E. COLI ...... 350 KRAVCHUN P.P...... 351

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ISIC-2016 Abstract book THE LIPID AND CARBOHYDRATE PROFILE IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS, TYPE 2 DIABETES AND OBESITY IN 6 MONTHS AND 1 YEAR AFTER MYOCARDIAL REVASCULARIZATION ...... 351 MAYOROVA MARGARITA, KOVALYOVA YULIA, SHELEST BORIS ...... 352 SMOKING AS RISK FACTOR AT PATIENTS WITH THE COMBINED COURSE OF ARTERIAL HYPERTENSION AND DIABETES 2 TYPES ...... 352 MEDYANIK E.A., MASLOVA E.S...... 353 ANALYSIS OF PROGNOSTIC FACTORS FOR EARLY MYOCARDIAL INFARCTION ...... 353 MELENEVYCH A. YA...... 354 IMPLICATION OF INTERLEUKIN-18 IN THE PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH HYPERTENSION ...... 354 MELENEVYCH A. YA...... 356 DIAGNOSTIC AND PROGNOSTIC ROLE OF MARKERS OF IMMUNE INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH HYPERTENSION ...... 356 MIESHCHANINA D.R...... 357 THE THERAPY OF CIRCULATORY FAILURE IN PATIENTS WITH CHRONIC PULMONARY HEART DISEASE ...... 357 MYKHAILIUK NATALIA VALERIIVNA ...... 358 APPLYING OF CARDIAC SHOCK-WAVE THERAPY IN THE PATIENTS WITH A STABLE ANGINA PECTORIS II-III FC ...... 358 MINUKHINA D.V., GABISONIYA T.N, SHAPIRKO E.A...... 360 PATHOGENETIC VALUE OF VISFATIN AND ADIPONECTIN IN PATIENTS WITH STABLE ANGINA AND OBESITY ...... 360 MOLOTYAGIN DMITRY, MIRONCHENKO ANASTASIA, SUKHOMLYN MYKOLA ...... 361 CLINICO-EPIDEMIOLOGICAL AND DIAGNOSTICAL ASPECTS OF THE OLLIER DISEASE...... 361 MOVCHAN Y.O., YAKYMENKO D.S ...... 362 DISORDERS OF LIPID METABOLISM IN PATIENTS WITH TYPE 2 DIABETES AND HYPOTHYROIDISM, CORRECTION OF THESE DISORDERS ...... 362 ONWUJEKWE UDODI E...... 363 MODERN ASPECTS OF TREATMENT OF RHEUMATOID ARTHRITIS ...... 363 POCHERNINA V...... 364 TOLL-LIKE RECEPTOS 4 AND 9 TYPES IN THE PATHOGENESIS OF PSORIASIS ...... 364 414

ISIC-2016 Abstract book PYLOV D.I...... 365 THE EFFICIENCY OF COMBINATION THERAPY OF BIGUANIDES, STATINS AND ALPHA-LIPOIC ACID ON LIPID PROFILE IN PATIENTS WITH DIABETES TYPE 2 AND DIFFERENT PHENOTYPES ...... 365 PYLOVA T.V., DUBIVSKA S.S...... 366 THE RISK OF MYOCARDIAL INFARCTION AND ACUTE STROKE AMONG THE PATIENTS WITH A COMBINATION OF THE TYPE 2 OF DIABETES MELLITUS AND ARTERIAL HYPERTENSION ...... 366 ROMANENKO O.R., TALALAIENKO O.K...... 368 REPERFUSION ARRHYTHMIAS IN PATIENTS OF DIFFERENT AGE WITH ACUTE MYOCARDIAL INFARCTION ...... 368 RYNCHAK P., ROSTOVTSEVA M...... 369 DAMAGE OF THE MYOCARDIUM IN PATIENTS WITH MITOCHONDRIAL DISEASES ...... 369 SALAWU K.T...... 370 THE EFFICIENCY OF DIFFERENT TREATMENT REGIMENS IN PATIENTS WITH PSORIASIS...... 370 SEMENOVYCH O. B...... 371 HYPERTENTION IMPACT ON RENAL FUNCTIONING. REVIEW OF NOWADAYS PROBLEMS ...... 371 SHALKOVSKYI Y.I., SUCHOK S.O. SGLT2 INHIBITORS - A NEW NON-INSULIN APPROACH TO THE TREATMENT OF DIABETES MELLITUS TYPE 2 ...... 372 O. P. KOZLOV, S. G. MALANCHUK, O. G. SOROKINA, D. S. MIKHAYLOVA ...... 373 THE RELATIONSHIP OF THE RIGHT LOBE’ SIZE OF THE LIVER WITH HEMODYNAMIC AND BIOCHEMICAL INDICATORS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH CARDIOVASCULAR PATHOLOGY ...... 373 O. G. SOROKINA, Y.Y. ZINCHENKO* ...... 375 THERAPEUTIC USE OF IMMUNOMODULATORY DRUGS IN THE TREATMENT OF PATIENTS WITH EPSTAIN-BARR VIRUS INFECTION ...... 375 STROIENKO K., KHYZHNYAK A., KHYZHNYAK K...... 376 OPTIMIZATION OF TREATMENT OF COGNITIVE DYSFUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ...... 376 SYPALO ANN ...... 377 DEFINITION OF SORTILIN IN OPTIMIZING THE DIAGNOSIS AND TREATMENT OF DYSLIPIDEMIA IN PATIENTS WITH ISCHAEMIC HEART DISEASE AND TYPE 2 DIABETES MELLITUS ...... 377 415

ISIC-2016 Abstract book TABACHENKO OLENA ...... 378 EFFECTS OF APELIN-12 IN THE DYNAMICS OF AMBULATORY BLOOD PRESSURE MONITORING FOR PATIENTS WITH ARTERIAL HYPERTENSION DEPENDING ON THE PRESENCE OR ABSENCE OF AN UNDERLYING TYPE 2 DIABETES ...... 378 TALALAIENKO O.K., ROMANENKO O...... 379 MILD PREECLAMPSIA AS A RISK FACTOR OF OBSTETRIC COMPLICATIONS 379 TECLEBRHAN MOSAY BERIHU, LERMAK ALEXANDRA SERGEIYEVNA ...... 380 BEHCET'S DISEASE ...... 380 TURMANIDZE KETEVANI IRAKLIEVNA...... 381 BIOMARKERS OF LEFT VENTRICLE REMODELING IN OVERWEIGHT PATIENTS WITH ESSENTIAL HYPERTENSION ...... 381 VILTSANIYK O.O., VILTSANIYK O...... 382 COMMUNITY ACQUIRED PNEUMONIA AND OPIOID DRUG ADDICTION: CLINICAL COURSE AND TREATMENT RESULTS ...... 382 VIVCHARUK YARYNA VASILYVNA ...... 383 MENSTRUAL IRREGULARITIES IN WOMEN OF REPRODUCTIVE AGE WITH HYPOTHYROIDISM AGAINST THE BACKGROUND OF AUTOIMMUNE THYROIDITIS ...... 383 YERMAK OLEKSANDRA SERGIIVNA, BORZOVA-KOSSE SOFIA, ADAMSKY MARK ...... 384 DYNAMICS OF COPEPTIN AND CARDIOHAEMODYNAMIC'S INDICATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH OBESITY ...... 384 YERYOMENKO G.V...... 385 THE ROLE OF VON WILLEBRAND FACTOR IN THE DEVELOPMENT OF INFLAMMATION IN PATIENTS WITH ASTHMA ...... 385 ZAIKINA T.S., BUTRIMOVA I.A...... 386 MARKERS OF COMPLICATED COURSE OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH CONCOMITANT DIABETES MELLITUS TYPE 2 ...... 386 ZAIKINA T. S., DIELIEVSKA V. YU., JEENA JUSTIN ...... 387 ALDOSTERONE INVOLVEMENT IN CHRONIC HEART FAILURE DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE ...... 387 ZAOZERSKAYA N.V., IRAKI HAMZA ...... 388 QUALITY OF LIFE AND PSYCHOLOGICAL TRAITS OF CHARACTER IN PATIENTS WITH DIFFERENT KIND OF CARDIOVASCULAR PATHOLOGY ...... 388 ZHURAVLYOVA A., OGNIEVA O...... 389 NONINVASIVE DIAGNOSIS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC LIVER DISEASE ...... 389 416

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