Abdominal X Rays Made Easy: Calcification
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Ligaments of the Costovertebral Joints Including Biomechanics, Innervations, and Clinical Applications: a Comprehensive Review W
Open Access Review Article DOI: 10.7759/cureus.874 Ligaments of the Costovertebral Joints including Biomechanics, Innervations, and Clinical Applications: A Comprehensive Review with Application to Approaches to the Thoracic Spine Erfanul Saker 1 , Rachel A. Graham 2 , Renee Nicholas 3 , Anthony V. D’Antoni 2 , Marios Loukas 1 , Rod J. Oskouian 4 , R. Shane Tubbs 5 1. Department of Anatomical Sciences, St. George's University School of Medicine, Grenada, West Indies 2. Department of Anatomy, The Sophie Davis School of Biomedical Education 3. Department of Physical Therapy, Samford University 4. Neurosurgery, Complex Spine, Swedish Neuroscience Institute 5. Neurosurgery, Seattle Science Foundation Corresponding author: Erfanul Saker, [email protected] Abstract Few studies have examined the costovertebral joint and its ligaments in detail. Therefore, the following review was performed to better elucidate their anatomy, function and involvement in pathology. Standard search engines were used to find studies concerning the costovertebral joints and ligaments. These often- overlooked ligaments of the body serve important functions in maintaining appropriate alignment between the ribs and spine. With an increasing interest in minimally invasive approaches to the thoracic spine and an improved understanding of the function and innervation of these ligaments, surgeons and clinicians should have a good working knowledge of these structures. Categories: Neurosurgery, Orthopedics, Rheumatology Keywords: costovertebral joint, spine, anatomy, thoracic Introduction And Background The costovertebral joint ligaments are relatively unknown and frequently overlooked anatomical structures [1]. Although small and short in size, they are abundant, comprising 108 costovertebral ligaments in the normal human thoracic spine, and they are essential to its stability and function [2-3]. -
Sarcoidosis, Hypercalcemia and Calcium-Sensing Receptor Mutation: a Case Report
468 Letters to the Editor Sarcoidosis, Hypercalcemia and Calcium-sensing Receptor Mutation: A Case Report Shreya Dixit1 and Pablo Fernandez-Peñas1,2* 1Skin and Cancer Foundation Australia, 7 Ashley Lane, Westmead, NSW 2145, and 2Sydney Medical School Western, The University of Sydney, NSW, Australia. *E-mail: [email protected] Accepted October 28, 2010. Sarcoidosis is a multisystem granulomatous disease of The incidence of hypercalcaemia in patients with unknown aetiology. It predominantly affects the lungs; sarcoidosis is approximately 10% (3). It has previously however, 25% of patients have skin involvement, ranging been found that these abnormalities of calcium metabo- from non-specific maculopapular eruptions to erythema lism are due to dysregulated production of calcitriol by nodosum and lupus pernio (1). activated macrophages trapped in pulmonary alveoli and Familial hypocalciuric hypercalcaemia (FHH) results granulomatous inflammation (4). Conversion of calcidiol from an autosomal dominantly inherited inactivating to calcitriol is facilitated by 1 alpha-hydroxylase, a cyto- mutation of the calcium-sensing receptor (CaSR) gene chrome P450 enzyme. The activity of 1 alpha-hydroxyla- and is typically asymptomatic (2). Sarcoidosis has not se is tightly regulated through complex mechanisms that previously been reported in FHH. We had the opportu- depend on the circulating levels of calcium, phosphorus, nity to study a patient with sarcoidosis that has a CaSR PTH, 1,25 (OH)2D3 (calcitriol) and calcitonin. The role mutation. of CaSR in the regulation of 1 alpha-hydroxylase has not been defined, although there are suggestions that CaSR activation can repress the enzyme (5). CASE REPORT The incidence of FHH in patients with sarcoidosis A 70-year-old woman was referred by her endocrinologist with is unknown. -
Part 1 the Thorax ECA1 7/18/06 6:30 PM Page 2 ECA1 7/18/06 6:30 PM Page 3
ECA1 7/18/06 6:30 PM Page 1 Part 1 The Thorax ECA1 7/18/06 6:30 PM Page 2 ECA1 7/18/06 6:30 PM Page 3 Surface anatomy and surface markings The experienced clinician spends much of his working life relating the surface anatomy of his patients to their deep structures (Fig. 1; see also Figs. 11 and 22). The following bony prominences can usually be palpated in the living subject (corresponding vertebral levels are given in brackets): •◊◊superior angle of the scapula (T2); •◊◊upper border of the manubrium sterni, the suprasternal notch (T2/3); •◊◊spine of the scapula (T3); •◊◊sternal angle (of Louis) — the transverse ridge at the manubrio-sternal junction (T4/5); •◊◊inferior angle of scapula (T8); •◊◊xiphisternal joint (T9); •◊◊lowest part of costal margin—10th rib (the subcostal line passes through L3). Note from Fig. 1 that the manubrium corresponds to the 3rd and 4th thoracic vertebrae and overlies the aortic arch, and that the sternum corre- sponds to the 5th to 8th vertebrae and neatly overlies the heart. Since the 1st and 12th ribs are difficult to feel, the ribs should be enu- merated from the 2nd costal cartilage, which articulates with the sternum at the angle of Louis. The spinous processes of all the thoracic vertebrae can be palpated in the midline posteriorly, but it should be remembered that the first spinous process that can be felt is that of C7 (the vertebra prominens). The position of the nipple varies considerably in the female, but in the male it usually lies in the 4th intercostal space about 4in (10cm) from the midline. -
Phytoplankton As Key Mediators of the Biological Carbon Pump: Their Responses to a Changing Climate
sustainability Review Phytoplankton as Key Mediators of the Biological Carbon Pump: Their Responses to a Changing Climate Samarpita Basu * ID and Katherine R. M. Mackey Earth System Science, University of California Irvine, Irvine, CA 92697, USA; [email protected] * Correspondence: [email protected] Received: 7 January 2018; Accepted: 12 March 2018; Published: 19 March 2018 Abstract: The world’s oceans are a major sink for atmospheric carbon dioxide (CO2). The biological carbon pump plays a vital role in the net transfer of CO2 from the atmosphere to the oceans and then to the sediments, subsequently maintaining atmospheric CO2 at significantly lower levels than would be the case if it did not exist. The efficiency of the biological pump is a function of phytoplankton physiology and community structure, which are in turn governed by the physical and chemical conditions of the ocean. However, only a few studies have focused on the importance of phytoplankton community structure to the biological pump. Because global change is expected to influence carbon and nutrient availability, temperature and light (via stratification), an improved understanding of how phytoplankton community size structure will respond in the future is required to gain insight into the biological pump and the ability of the ocean to act as a long-term sink for atmospheric CO2. This review article aims to explore the potential impacts of predicted changes in global temperature and the carbonate system on phytoplankton cell size, species and elemental composition, so as to shed light on the ability of the biological pump to sequester carbon in the future ocean. -
Acute Onset Flank Pain-Suspicion of Stone Disease (Urolithiasis)
Date of origin: 1995 Last review date: 2015 American College of Radiology ® ACR Appropriateness Criteria Clinical Condition: Acute Onset Flank Pain—Suspicion of Stone Disease (Urolithiasis) Variant 1: Suspicion of stone disease. Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without IV 8 Reduced-dose techniques are preferred. contrast ☢☢☢ This procedure is indicated if CT without contrast does not explain pain or reveals CT abdomen and pelvis without and with 6 an abnormality that should be further IV contrast ☢☢☢☢ assessed with contrast (eg, stone versus phleboliths). US color Doppler kidneys and bladder 6 O retroperitoneal Radiography intravenous urography 4 ☢☢☢ MRI abdomen and pelvis without IV 4 MR urography. O contrast MRI abdomen and pelvis without and with 4 MR urography. O IV contrast This procedure can be performed with US X-ray abdomen and pelvis (KUB) 3 as an alternative to NCCT. ☢☢ CT abdomen and pelvis with IV contrast 2 ☢☢☢ *Relative Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate Radiation Level Variant 2: Recurrent symptoms of stone disease. Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without IV 7 Reduced-dose techniques are preferred. contrast ☢☢☢ This procedure is indicated in an emergent setting for acute management to evaluate for hydronephrosis. For planning and US color Doppler kidneys and bladder 7 intervention, US is generally not adequate O retroperitoneal and CT is complementary as CT more accurately characterizes stone size and location. This procedure is indicated if CT without contrast does not explain pain or reveals CT abdomen and pelvis without and with 6 an abnormality that should be further IV contrast ☢☢☢☢ assessed with contrast (eg, stone versus phleboliths). -
Reduced Calcification of Marine Plankton in Response to Increased
letters to nature Acknowledgements representatives of the coccolithophorids, Emiliania huxleyi and This research was sponsored by the EPSRC. T.W.F. ®rst suggested the electrochemical Gephyrocapsa oceanica, are both bloom-forming and have a deoxidation of titanium metal. G.Z.C. was the ®rst to observe that it was possible to reduce world-wide distribution. G. oceanica is the dominant coccolitho- thick layers of oxide on titanium metal using molten salt electrochemistry. D.J.F. suggested phorid in neritic environments of tropical waters9, whereas the experiment, which was carried out by G.Z.C., on the reduction of the solid titanium dioxide pellets. M. S. P. Shaffer took the original SEM image of Fig. 4a. E. huxleyi, one of the most prominent producers of calcium carbonate in the world ocean10, forms extensive blooms covering Correspondence and requests for materials should be addressed to D. J. F. large areas in temperate and subpolar latitudes9,11. (e-mail: [email protected]). The response of these two species to CO2-related changes in seawater carbonate chemistry was examined under controlled ................................................................. pH Reduced calci®cation 8.4 8.2 8.1 8.0 7.9 7.8 PCO2 (p.p.m.v.) of marine plankton in response 200 400 600 800 a 10 to increased atmospheric CO2 ) 8 –1 Ulf Riebesell *, Ingrid Zondervan*, BjoÈrn Rost*, Philippe D. Tortell², d –1 Richard E. Zeebe*³ & FrancËois M. M. Morel² 6 * Alfred Wegener Institute for Polar and Marine Research, P.O. Box 120161, 4 D-27515 Bremerhaven, Germany mol C cell –13 ² Department of Geosciences & Department of Ecology and Evolutionary Biology, POC production Princeton University, Princeton, New Jersey 08544, USA (10 2 ³ Lamont-Doherty Earth Observatory, Columbia University, Palisades, New York 10964, USA 0 ............................................................................................................................................. -
The Effects of Aging on the Material Properties of Human Costal Cartilage
The Effects of Aging on the Material Properties of Human Costal Cartilage A. G. Lau1, J. M. Mattice1, D. Murakami2, M. L. Oyen1, and R. W. Kent1 1 University of Virginia; 2Nissan Motor Corporation ABSTRACT Understanding the mechanical properties of the aging thorax is important in the development of restraint systems to protect the older population. This study investigated how the material properties of costal cartilage change with age. Indentation testing was used to study the material properties of human costal cartilage. Ribcages were obtained from 11 human subjects ranging in age from 23 to 77 years. Costal cartilage from the second, third, and fourth left ribs were excised and prepared into 6 mm thick cross sections. The cross sections were tested using spherical indentation with a ramp-hold relaxation test. Shear and elastic moduli were calculated from the stress relaxation response. The results showed only a slight trend of increasing costal cartilage stiffness with age and there was a larger overall standard deviation in the older specimen values. Differences were observed during specimen preparation which included changes in color, increasing inhomogeneity, and varying regions of calcification. Calcification was observed as shells surrounding the softer cartilage, as well as calcified strata running transversely through the interior of the cartilage. These regions should affect the overall mechanical response during thoracic loading, but were not as apparent in the results of the current study because the indentation area was localized near the center of the cartilage cross sections. 1 This paper has not been peer- reviewed and should not be referenced in open literature. -
The Influence of the Rib Cage on the Static and Dynamic Stability
www.nature.com/scientificreports OPEN The infuence of the rib cage on the static and dynamic stability responses of the scoliotic spine Shaowei Jia1,2, Liying Lin3, Hufei Yang2, Jie Fan2, Shunxin Zhang2 & Li Han3* The thoracic cage plays an important role in maintaining the stability of the thoracolumbar spine. In this study, the infuence of a rib cage on static and dynamic responses in normal and scoliotic spines was investigated. Four spinal fnite element (FE) models (T1–S), representing a normal spine with rib cage (N1), normal spine without rib cage (N2), a scoliotic spine with rib cage (S1) and a scoliotic spine without rib cage (S2), were established based on computed tomography (CT) images, and static, modal, and steady-state analyses were conducted. In S2, the Von Mises stress (VMS) was clearly decreased compared to S1 for four bending loadings. N2 and N1 showed a similar VMS to each other, and there was a signifcant increase in axial compression in N2 and S2 compared to N1 and S1, respectively. The U magnitude values of N2 and S2 were higher than in N1 and S1 for fve loadings, respectively. The resonant frequencies of N2 and S2 were lower than those in N1 and S1, respectively. In steady-state analysis, maximum amplitudes of vibration for N2 and S2 were signifcantly larger than N1 and S1, respectively. This study has revealed that the rib cage improves spinal stability in vibrating environments and contributes to stability in scoliotic spines under static and dynamic loadings. Scoliosis, a three-dimensional deformity, prevents healthy development. -
Rib Cartilage Injuries
PHYSIO4ALL revitalise – bounce – be healthy Rib Cartilage Injuries Structure of the ribcage The ribcage supports the upper body, protects internal organs including the heart and lungs, and assists with breathing. It consists of 24 curved ribs arranged in 12 pairs. Each pair is attached to a vertebra in the spine. At the front of the body, the first seven pairs of ribs are attached directly to the sternum (breastbone) by cartilage known as costal cartilage. These ribs are often called ‘true ribs’. The next three pairs aren’t connected to the sternum. Instead, costal cartilage attaches these ‘false ribs’ to the last pair of true ribs. The remaining two pairs aren’t attached at the front of the body at all and are known as ‘floating ribs’. The ribcage is supported by ligaments and muscles, including the muscles between the ribs (intercostal muscles). These muscles allow the ribcage to expand when you breathe in, and drop when you breathe out. Rib injuries include bruises, torn cartilage and bone fractures. Shop No. P16, NorthPoint, 100 Miller St. North Sydney. NSW – 2060 T – (02) 99222212 F – (02) 99225577 W: www.physio4all.com.au E: [email protected] ABN: 77 548 297 578 PHYSIO4ALL revitalise – bounce – be healthy Symptoms of rib cartilage injury Symptoms of rib injuries depend on the type and severity of the injury, but can include: • Pain at the injury site • Pain when the ribcage flexes – for example when you breathe, cough, sneeze or laugh • Pain when rotating or side flexing your spine • Crunching or grinding sounds (crepitus) when the injury site is touched or moved • Muscle spasms of the ribcage • Deformed appearance of the ribcage • Breathing difficulties. -
Distribution of Calcium Phosphate in the Exoskeleton of Larval Exeretonevra Angustifrons Hardy (Diptera: Xylophagidae)
Arthropod Structure & Development 34 (2005) 41–48 www.elsevier.com/locate/asd Distribution of calcium phosphate in the exoskeleton of larval Exeretonevra angustifrons Hardy (Diptera: Xylophagidae) Bronwen W. Cribba,b,*, Ron Rascha, John Barrya, Christopher M. Palmerb,1 aCentre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Qd 4072, Australia bDepartment of Zoology and Entomology, The University of Queensland, Brisbane, Qd 4072, Australia Received 28 July 2004; accepted 26 August 2004 Abstract Distribution and organisation of the mineral, amorphous calcium phosphate (ACP), has been investigated in the exoskeleton of the xylophagid fly larva Exeretonevra angustifrons Hardy. While head capsule and anal plate are smooth with a thin epicuticle, the epicuticle of the body is thicker and shows unusual micro-architecture comprised of minute hemispherical (dome-shaped) protrusions. Electron microprobe analysis and energy dispersive spectroscopy revealed heterogeneity of mineral elements across body cuticle and a concentration of ACP in the epicuticle, especially associated with the hemispherical structures. Further imaging and analysis showed the bulk of the ACP to be present in nano-sized granules. It is hypothesised that the specific distribution of ACP may enhance cuticular hardness or durability without reducing flexibility. q 2004 Elsevier Ltd. All rights reserved. Keywords: Insect; Cuticle; Integument; Hardening; Analytical electron microscopy; Electron microprobe 1. Introduction was distributed heterogeneously. Further investigation of the distribution of the mineral phase at the micron and Strengthening of biological structures through cuticular nanometre level is needed to discover where deposition is calcification is well developed in decapod crustaceans but it occurring and how this might affect exoskeletal organis- rarely occurs in insects, where it is poorly understood ation. -
Study of Calculus Pancreatitis
STUDY OF CALCULUS PANCREATITIS Dissertation Submitted for MS Degree (Branch I) General Surgery April 2011 The Tamilnadu Dr.M.G.R.Medical University Chennai – 600 032. MADURAI MEDICAL COLLEGE, MADURAI. CERTIFICATE This is to certify that this dissertation titled “STUDY OF CALCULUS PANCREATITIS” submitted by DR.P.K.PRABU to the faculty of General Surgery, The Tamilnadu Dr. M.G.R. Medical University, Chennai in partial fulfillment of the requirement for the award of MS degree Branch I General Surgery, is a bonafide research work carried out by him under our direct supervision and guidance from October 2008 to October 2010. DR. M.GOPINATH, M.S., Pro. A.SANKARAMAHALINGAM M.S, PROFESSOR AND HEAD, PROFESSOR, DEPARTMENT OF GENERAL SURGERY, DEPARTMENT OF GENERAL SURGERY, MADURAI MEDICAL COLLEGE, MADURAI MEDICAL COLLEGE, MADURAI. MADURAI. DECLARATION I, DR.P.K.PRABU solemnly declare that the dissertation titled “STUDY OF CALCULUS PANCREATITIS” has been prepared by me. This is submitted to The Tamilnadu Dr. M.G.R. Medical University, Chennai, in partial fulfillment of the regulations for the award of MS degree (Branch I) General Surgery. Place: Madurai DR. P.K.PRABU Date: ACKNOWLEDGEMENT At the very outset I would like to thank Dr.A.EDWIN JOE M.D.,(FM) the Dean Madurai Medical College and Dr.S.M.SIVAKUMAR M.S., (General Surgery) Medical Superintendent, Government Rajaji Hospital, Madurai for permitting me to carryout this study in this Hospital. I wish to express my sincere thanks to my Head of the Department of Surgery Prof.Dr.M.GOPINATH M.S., and Prof.Dr.MUTHUKRISHNAN M.Ch., Head of the Department of Surgical Gastroenterology for his unstinted encouragement and valuable guidance during this study. -
MULTIPLE OSSIFIED COSTAL CARTILAGES for 1ST RIB Raghavendra D.R
International Journal of Anatomy and Research, Int J Anat Res 2014, Vol 2(4):744-47. ISSN 2321- 4287 Case Report DOI: 10.16965/ijar.2014.538 MULTIPLE OSSIFIED COSTAL CARTILAGES FOR 1ST RIB Raghavendra D.R. *1, Nirmala D 2. *1 Post graduate student, Department of anatomy, J J M Medical College, Davangere, Karnataka, India. 2 Associate Professor, Department of anatomy, J J M Medical College, Davangere, Karnataka, India. ABSTRACT Costal cartilages are flattened bars of hyaline cartilages. All ribs except the last two, join with the sternum through their respective costal cartilages directly or indirectly. During dissection for 1st MBBS students in the Department of Anatomy, JJMMC, Davangere, variation was found in a male cadaver aged 45 –50 years. Multiple ossified costal cartilages for 1st rib were present on left side. There were 3 costal cartilages connecting 1st rib to manubrium. There were two small intercostal spaces between them. The lower two small costal cartilages fused together to form a common segment which in turn fused with large upper costal cartilage. The large upper costal cartilage forms costochondral joint with 1st rib. All costal cartilages showed features of calcification. The present variation of multiple ossified costal cartilages are due to bifurcation of costal cartilage. It may cause musculoskeletal pain, intercostal nerve entrapment or vascular compression. Awareness of these anomalies are important for radiologists for diagnostic purpose and for surgeons for performing various clinical and surgical procedures. KEYWORDS: Costal cartilage, bifurcation of Rib, Sternum. Address for Correspondence: Dr. Raghavendra D.R. Post graduate student, Department of anatomy, J J M Medical College, Davangere, 577004, Karnataka, India.