Nanotechnology & @ UIC ( & Science)

by

G.Ali Mansoori, PhD [email protected] BioEngineering, & Physics Departments

at Livingston Conference Chicago, IL, December 2014 ABSTRACT • An overview of Speaker’s R&D work on design of , nanoclusters, nanoconjugates and molecular building blocks and their applications in science, engineering and health. Our Atomic Force Microscopes Mansoori Group Research Topics www.uic.edu/~mansoori/

1. Cancer nanotechnology: a. Melanoma prevention through nanotechnology b. Applications of Azurin as an anti-cancer agent. c. Targeting the Folate Receptor.

2. Silver nanoparticles large-scale (industrial) production

3. Diamomdoids as molecular building block for nanotechnology Mansoori Group Research Topics continued • 4. Molecular based study of condensed matter in small confined systems

• 5. Applications of supercritical fluid for bioseparations

• 6. Environmental aspects of nanotechnology

• 7. Alzheimer’s disease detection & treatment through nanotechnology. Design, characterization and application of a folate-conjugated gold

• Gold Nanoparticles Conjugated with Folic Acid using Mercaptohexanol as the Linker Journal Nanotechnology Progress International (JONPI), 1: 13-23, 2009. • Structural and optical characterization of folate-conjugated gold-nanoparticles Physica E: Low-dimensional Systems and Nanostructures, doi:10.1016/j.physe.2009.10.039. • Cancerous Cells Targeting and Destruction Using Folate Conjugated Gold Nanoparticles Dynamic , Process and Molecular , Vol. 4, 2010.(Article in Press) • Folate-Conjugated Gold Nanoparticles (Synthesis, characterization and design for cancer cells nanotechnology-based targeting) Int'l J of Nanoscience & Nanotechnology, 2010.(Article in Press) . Design, characterization and application of a

folate-conjugated gold nanoparticle continued Melanoma prevention through nanotechnology

Acrobat Document

A patent pending. Applications of Azurin as an anti-cancer agent

• Azurin: A Novel Anticancer Candidate (Molecular Characteristics, Apoptosis Mechanism and Nanotechnology)

Prospects for Cancer Nanotechnology Treatment by Azurin Dynamic Biochemistry, Process Biotechnology and , Vol. 4, 2010. Silver Nanoparticles production and medical applications • of Silver Nanoparticles by Fungus Trichoderma Reesei (A Route for Large-Scale Production of SNP)

• (Left) TEM micrograph recorded from a drop-coated film of an aqueous solution incubated with Trichoderma reesei and reacted with Ag+ ions for 72 hours. (Right) Selected area of electron diffraction pattern recorded from one of the silver nanoparticles shown in the left Figure. The diffraction rings have been indexed with reference to the fcc silver. • Patented Alzheimer’s Disease Nanotechnology:

Early detection of AD through nanotechnology

Sequential formation of globular aggregates

RECENT PUBLICATIONS: Nanotechnology Building Blocks for Intervention with Alzheimer’s Disease : Implications in Disease Modifying Strategies J Bioanal. & Biomed., Vol.6, Issue 2, 6:009-014. doi: 10.4172/1948-593X.1000101, 2014

Nanotechnology for Alzheimer's disease detection and treatment (Invited paper) Nanotechnology Sec. / Insciences J. 2011, 1(4), 169- 193;doi:10.5640/insc.0104169

Nanotechnology Solutions for Alzheimer's Disease: (Advances in research tools, diagnostic methods and therapeutic agents) Journal of Alzheimer's Disease, 13(2): pp. 199-223, 2008. Diamomdoids as molecular Our team building block for nanotechnology

Measurement, and Prediction of Intermolecular Interactions and Structural Characteristics of Organic Nanostructures (Diamondoids and Derivatives)What we do 1. THEORY: Generating & testing the basis sets. Structure optimization. Comparing bond lengths with experiment. Creating and testing potentials for diamondoids & derivatives and pseudopotentials for metal tips. Testing different density functionals (B3LYP, GGA, LSDA & LDA). Testing and comparing results from the ab initio codes ( Molpro, Gaussian 03, etc.). Treating valence electrons Our tools exactly. 1. Ab initio calculations 2. EXPERIMENTS: Preparing monolayers of diamondoids. Obtaining images with AFM and/or STM. Preparing samples 2. MD simulation using different solvents (THF, toluene, etc) with different 3. Molecular self-assembly degrees of concentration levels. Choosing substrates (Si, 4. Scanning Mica, etc.). Choosing preparation techniques (drop, probe spinning, etc.). Force-distance calculations and microcopy characterization (through XPS, STM, and AFM). Testing versus THEORY results.

3. : Simulations to produce self-assemblies for new materials with desired optoelectronic properties as MEMS, NEMS and other micro- and nano-gears and devices. Utilizing the intermolecular potential data produced in the above sections. Our samples:

Our findings:

Sense the hardness “See” the Feel the potential Self-assembly

Our goals:

Supported by the U.S. Army Research Office Applications of supercritical fluid technology for bio systems

• In this project we propose to apply supercritical fluid technology for vaporization and ionization of biological aerosols which will not require collection on a substrate or probe. The basics of the process Supercritical fluid screening system to be used in the experimental part of the project Investigating Fate, Transport, Transformation, and Exposure of Engineered

Transport, Reactivity, Transformation, and Toxicity of Lactate-Modified Nanoscale Iron Particles In Field Contaminated Soils

Structure of nZVI particles SEM image of nZVI particles Environmental Applications of Nanotechnology – Annual Review of Nano Research, Vol.2, Chapter 2, 2008. Molecular based study of condensed matter in small confined systems

Behavior of confined fluids in nanoslit pores: the normal pressure tensor Microfluidics and Nanofluidics, 8(1): pp.97-104,January 2010; DOI: 10.1007/s10404-009-0449-

BEHAVIOR OF THE CONFINED HARD-SPHERE FLUID WITHIN NANOSLITS: A FUNDAMENTAL-MEASURE DENSITY- FUNCTIONAL THEORY STUDY Int'l J of Nanoscience, 7(4-5): pp. 245-253, 2008; DOI: 10.1142/S0219581X08005365.

An Analytic Model for Nano Confined Fluids Phase-Transition: Applications for Confined Fluids in Nanotube and Nanoslit J. Comput'l & Theor'l Nanoscience, 3(1):134-141, 2006. Our Nano and Nanobio Courses at UIC

BioE 405: Atomic & Molecular Nanotechnology www.uic.edu/classes/bioe/bioe405

3 OR 4 hours. Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and , quantum mechanical phenomena. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major.

BioE 505: NanoBioTechnology www.uic.edu/classes/bioe/bioe505

4 hours. Nanotechnology theory and applications in biology and . Molecular simulations, combinatorial chemistry. Nanoscale structures, molecular building blocks, integrated nano-bio complexes. Positional and self-assembly, self-replication. Recommended background: Engineering or physical sciences Our Nanotechnology & Nanobiotechnology Completed Projects Nanotechnology books we have published Nanotechnology books we have published Thank you for your attention!

Copy of this presentation is at: www.uic.edu/labs/trl/UIC-NANO.pdf