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Aug. 29, 2003 Volume 28 No. 3

Treasuring the Past NJvcishington University in StLouis Shaping the Future CelebratmgJSQYears GWB dean search committee named Khinduka announces retirement

BY JESSICA MARTIN this school, he has provided incomparable leadership to the A search committee to identify social work profession both candidates for the position nationally and internationally. of dean of the George "His vision and leadership Warren Brown School of Social have had a tremendous impact Work has been appointed by on the University as well, lifting Chancellor Mark S. Wrighton. our visibility and building our Shanti K. Khinduka, Ph.D., identity as a major research insti- announced that on June tution." 30 he will retire as dean Khinduka's tenure is one after 30 years of service. of the longest in the nation After a sabbatical, Khin- for a social work dean and duka will retain his posi- the longest of the current tion as the George War- University deans. ren Brown Distinguished Highlights of his term University Professor. include GWB's receiving top The 14-member com- ranking by peer schools of Khinduka mittee will be chaired by social work; construction of Enola E. Proctor, Ph.D., the $13 million Goldfarb the Frank J. Bruno Professor of Hall and renovation of Brown Social Work Research. Hall; formation of centers of "Shanti Khinduka has led the pathbreaking research in areas Welcome tO yOUr new home The South 40 was buzzing Aug. 21 as freshmen arrived and School of Social Work brilliantly such as addiction, mental-health moved into their residence halls. With the help of families, friends and members of the Congress of for three decades," Wrighton said. services, social development and the South 40 — including Amanda Juarez (left) and Jay Turetzky — the Class of 2007 settled in de- "In addition to the crucial role he support of American Indians; spite a record high temperature of 104 degrees. For more on this year's freshman class, see Page 5. has had in the development of See GWB dean, Page 5 Fall Assembly Series Largest human chromosome so far sequenced BY DARRELL E. WARD closely resemble genes but contain be very useful for follow-up opened by Bollinger some genetic change that prevents studies that have a medical appli- School of Medicine researchers, them from functioning like a cation." BY BARBARA REA in collaboration with investi- gene. The biological significance The work may benefit research gators at seven other centers, have in cystic fibrosis, deafness, B-cell Ehrenreich of pseudogenes is unknown. The 14 events offered this fall under the auspices of finished sequencing human chro- "This work completes another lymphoma and other cancer genes the Assembly Series will feature speakers and topics mosome 7 — the largest human volume in the genome encyclope- that are found on chromosome 7. chosen to reflect the scholarly pursuits of the faculty chromosome to be sequenced yet. dia at a high standard of quality The gene for P-glycoproteih, a and students at the University. The findings were published and a high degree of continuity," protein that enables cancer cells to Highlights include several prominent scientists and in a recent issue of the journal said principal investigator Richard resist anticancer drugs, is also colloquia on the environment. Many lectures on the fall Nature. K. Wilson, Ph.D., director of the found there. schedule are part of the University's Sesquicentennial The analysis revealed that the Genome Sequencing Center and Other important genes found celebration. chromosome has about 1,150 professor of genetics and of on chromosome 7 include those All Assembly Series lectures are free and open to the genes and 940 so-called pseudo- molecular microbiology. "The that help control cell division and public and are held at 11 a.m. in Graham Chapel unless Rodriguez genes, or stretches of DNA that sequence for chromosome 7 will See Chromosome, Page 5 otherwise noted. The series opens Sept. 10 with distinguished legal scholar and Columbia University President Lee C. Bollinger, who will draw upon his expertise in free WUSTL, Monsanto awarded crop protection patent speech and First Amendment issues to deliver a talk on BY TONY FITZPATRICK in Arts & Sciences; Robert T. develop disease-resistant varieties "The Foundations of the Principle of Academic Free- Fraley, Ph.D., Monsanto chief of papaya to protect against dom." His talk also is the School of Law Sesquicenten- The University and Monsanto technology officer; and former papaya ringspot virus. nial Lecture. Co. have been issued a patent Monsanto research scientist Beachy and his collaborators A graduate of the University of Oregon and for a technique that protects crops Stephen G. Rogers. are researching viral resistance in Gregory Columbia University Law School, Bollinger served as a from devastating viral diseases Over the past 16 years, ongo- numerous other plants, including law clerk for Judge Wilfred Feinberg on the U.S. Court that threaten or harm many ing research and development in rice and cassava. of Appeals for the 2nd Circuit and also for Chief Justice important food crops. laboratories around the world Monsanto has donated rights Warren Burger on the U.S. Supreme Court. The technique received patent have led to virus-resistant vari- to the technology to a number of His teaching career began at the University of No. 6,608,241 from the U.S. Pat- eties of tomato, pepper, cucum- public institutions. Michigan Law School in 1973, and he assumed the ent Office. ber, squash, sugar beets, papaya "The sharing of this technolo- deanship in 1987. Since then, he has held several top The inventors are Roger N. and plum, among other crops. gy has been critical in creating administrative posts, including provost at Dartmouth Beachy, Ph.D., president of the Recently, scientists at the Univer- virus-resistant crops for develop- College and president at the University of Michigan. Donald Danforth Plant Science sity of Hawaii and their collabo- ing countries around the world," See Series, Page 6 Hochschild Center and professor of biology rators used the technique to See Patent, Page 7 This Week In Gallery of Art exhibition charts growth of University WUSTL History BY LIAM OTTEN succession, Washington Institute of chronicling key figures, events and ^UVER- St. Louis (1854), O'Fallon Institute discoveries in the life of the University, September 1870 & On Feb. 9, 1853, state Sen. Wayman (1855) and, finally, Washington Uni- as well as their roles on the larger his- For the first time, women were a Crow introduced a charter in the versity (1856). torical stage. allowed to take classes in the O Missouri Legislature creating Eliot Of course, much else has changed Influence 150 will open with a Collegiate Department alongside the 150 Seminary, a new educational institu- over the past 150 years, and the small reception from 5:30-8 p.m. Sept. 5 in male students. years I tion named in honor of his close friend school Crow and Eliot founded has the Gallery of Art and will remain on This feature will be included in and pastor, William Greenleaf Eliot. grown to national prominence and view through Dec. 7. each 2003-04 issue of the Record Yet Eliot, who would direct the respect. This fall, the University will "Influence 150 examines two major, Treasuring the Past in observance of Washington school's Board of Trustees until his celebrate that history with Influence if parallel, themes," said Shirley K. Shaping the Future University's 150th anniversary. death in 1887, was a modest man, and 150: 150 Years of Shaping a City, a Baker, vice chancellor for information thus Eliot Seminary became, in short Nation, the World, an exhibition See Exhibition, Page 6 2 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS International Writers Center becomes The Center for the Humanities Under the guidance of its ad- brief remarks by Chancellor Mark being redefined. It remains dedi- Advisory board members visory board, the Interna- S. Wrighton; Edward S. Macias, cated to letters, to things inter- tional Writers Center in Arts Ph.D., executive vice chancellor national, and to writers, and it & Sciences is expanding its mis- and dean of Arts & Sciences; and will continue to have visiting The Center for the Humanities adviso- Angela Miller, associate professor in sion and, to reflect this growth, Gerald L. Early, Ph.D., director of writers, readings and the like. ry board members: art history and archaeology in Arts & Sciences; Linda J. Nicholson, the changing its name. The Center for the Humanities. A "But the center also wishes Nancy Berg, associate professor in Stiritz Distinguished Professor in In September, the Interna- reception will be held immediate- to broaden its outreach, not only Asian and Near Eastern languages and Women's Studies and History in Arts tional Writers Center will become ly following the to a variety of scholars on our literatures in Arts & Sciences; Ken & Sciences; Dolores Pesce, professor The Center for the Humanities remarks. campus, but to the community Botnick, associate professor in the in music in Arts & Sciences; with the tag line: Dedicated Although as well." School of Art; Letty Chen, assistant to Letters and Humanistic The Center for One example of this new professor in Asian and Near Eastern Carl Phillips, professor in English in Research and Their Presence the Humanities outreach was a conference on languages and literatures; Arts & Sciences; Joe Pollack, KWMU- in the Public Life. will continue to the Korean War that the center FM theater and film critic; Jeff Smith, Don Fehr, senior editor and director To recognize its new mission focus on litera- hosted in May. Co-sponsored by associate professor in the PAD and of the Smithsonian Institution Press; and name and to show apprecia- ture and the act the Missouri Historical Society, director of Film and Media Studies in Daniel Halpern, publisher and editori- tion for those who have support- of writing, it the conference included talks by Arts & Sciences; James V. Wertsch, al director of The Ecco Press; Robert ed the center since its founding in will expand its faculty from numerous disci- the Marshall S. Snow Professor in Early Henke, associate professor in the October 1990, The Center for the reach within plines and institutions in the Arts & Sciences; and ex officio, Performing Arts Department in Arts & Humanities will host a ceremony the humanities St. Louis area as well as local Edward S. Macias, executive vice Sciences; Larry May, professor in phi- and celebration at 4 p.m. Sept. 2 to be more inclusive of other veterans. chancellor and dean of Arts & losophy in Arts & Sciences; in the Women's Building Formal scholars and various segments of Future projects on children Sciences. Lounge. the larger community. and film, the meaning of war, The event, which is free and "The reason for the change is and public intellectuals are being University, the community it open to the public, will include simple," Early said. "The center is planned. The center also hopes newsletter The Figure in the to launch semester-long visits Carpet, which features the serves and the world. by writers and scholars and to St. Louis Literary Calendar. "We are very excited about offer programs involving K-12 The center will maintain this new direction," Early said. education. its commitment to fostering "It shows how much faith the Campus Watch "What we want is not a dif- literary communities within advisory board has in the center ferent center, merely, but a bet- the University and around and how much potential the The following incidents were reported to University Police Aug. 5-26. Readers with informa- ter center," Early said. "Our St. Louis. center has to be a compelling tion that could assist in investigating these incidents are urged to call 935-5555. This infor- emphasis on the humanities In addition, as reflected in its voice for the humanities on the mation is provided as a public service to promote safety awareness and is available on the is a reassertion of what I think updated mission statement, The campus and in St. Louis." University Police Web site at police.wustl.edu. is the core of education itself: Center for the Humanities will Beginning Sept. 1, the cen- ter's e-mail address will be Aug. 6 Aug. 14 reading, writing and what it embrace a variety of humanistic means to do either and how pursuits. The center is dedicated [email protected] and 8:57 a.m. — An unknown person 1:37 p.m. — A classroom manag- both make meaning." to the promotion and preserva- its Web site address will be took a recorder and a headset from er for the Teaching Center report- The Center for the Human- tion of humanistic thinking and cenhum.artsci.wustl.edu. a lab in the Psychology Building. ed that an unknown person broke ities will continue to produce the pursuit of letters as essential For more information on Total loss is estimated at $900. into the audio cabinet in Brown the bi-monthly. Belles Lettres: a activities in the intellectual, the ceremony and celebration, Hall and stole a DVD/laser disc Literary Review and the monthly political and artistic life of the call 935-5576. player sometime between 2:30 Aug. 25 p.m. Aug. 5 and 11:30 a.m. Aug. 6. 1:12 p.m. — A student reported Total loss is estimated at $500. the theft of his Enterprise rental vehicle from the first level of the Aug. 13 Snow Way parking garage some- Benefits launches college tuition savings program time between 5 p.m. Aug. 24 and 12:53 p.m. — A visitor reported BY ANDY CLENDENNEN both state and federally tax-free; Room 2128. the theft of a cellular phone from 9 a.m. Aug. 25. Total loss is esti- qualified expenses including • The Hilltop Campus presen- mated at $12,000. her son's athletic bag, which was To help with the costs of col- tuition, fees, certain room and tation will be from noon-1 p.m. in Mallinckrodt Student Center. lege, the Office of Human board, books, supplies and equip- Sept. 10 in Simon Hall, Room Additionally, University Police The son was attending the Resources is offering its newest ment; use of funds at any eligible 120. The information table will responded to nine reports of larceny, Maccabi Games, and the theft benefit — the Missouri Saving post-secondary institution in the be set up from 10 a.m.-2 p.m. in three spills, two auto accidents, two occurred sometime between for Tuition Program (MO$T), a country; and three investment The Gargoyle in Mallinckrodt disturbances and one report each of 11 a.m. Aug. 12 and noon Aug. flexible higher-education savings options with TIAA-CREF. Student Center. suspicious person and fraud. 13. Total loss is estimated at $100. program. The program requires an initial • The Medical Campus pres- Effective Oct. 1, active bene- minimum contribution of $25 entation will be from 11:30 a.m.- fits-eligible faculty and staff of with an online application, or $15 12:30 p.m. Sept. 11 in Cori PICTURING OUR PAST the University will have the per account per pay period, Auditorium. The information opportunity to make contribu- through direct deposit. table will be set up from 10 a.m.- tions to a MO$T account To learn more, attend one of the 2 p.m. in the Seashell Lobby. through the convenience of following brown-bag lunch presen- To obtain more information direct deposit for a child, grand- tations or visit with a MO$T repre- about MO$T, call (888) 414- child or another family member, sentative at an information table: MOST or go online to www. including the employee. • A West Campus presentation missourimost.org. Benefits of enrolling in the will be from 11:30 a.m.-12:30 p.m. To access the application MO$T program include a Sept. 9 in the Library Conference forms, either go to the MO$T Missouri state income tax deduc- Center, Room A/B. The informa- Web site at the address above or tion of up to $8,000 annually; tion table will be set up from 10 go to the human-resources Web investment earnings that grow a.m.-2 p.m. in multipurpose site, hr.wustl.edu. Physics rolls out Science Saturdays lectures

sik, Ph.D., professor of physics, BY ANDY CLENDENNEN in the Laboratory," Thomas Ber- natowicz, Ph.D., professor of will present "The Connections Between Subnuclear Particles and University College and the De- physics. the Expansion of the Universe" at partment of Physics, both in • Oct. 18: "Biophysics of Cell Arts & Sciences, are inviting the Motion," Anders Carlsson, Ph.D., 2 p.m. Sept. 12. Lectures are free and open to public to join University scholars professor of physics. the public; no registration is and teachers in their annual explo- • Oct. 25: "Atomic Shuffle: ration of the frontiers of science. The Role of Nucleation in the required. The Fall 2003 Science Saturdays Formation of Materials," Kenneth For more information on series of lectures, part of the Kelton, Ph.D., professor of the individual lectures, go to wuphys.wustl.edu/Events/Docs/ University's Sesquicentennial cele- physics. SaturdayMorningSeminar.html. bration, will feature selected mem- Additionally, Ramanath Cow- bers of the physics department presenting their research in a pub- lic forum. All lectures start at 10 a.m. and will be in Crow Hall, Room 201. Record (USPS 600-430; ISSN 1043-0520), Lecture dates and topics are Volume 28, Number 3/Aug. 29, 2003. Washington University community news Published for the faculty, staff and friends ,vr listed below. Jimmy Carter delivers an address as a guest of u* "*'J> of Washington University. Produced weekly Editor Kevin M. Kiley the School of Law in 1975 while he was still • Sept. 6: "The Second Quan- during the school year, except school Associate Editor Andy Clendennen governor of Georgia. After a term as president, tum Revolution," John Clark, holidays, and monthly during June, July and Assistant Editor Neil Schoenherr Ph.D., the Wayman Crow Professor August by the Office of Public Affairs, Carter returned to the University to speak as 150years Associate Vice Chancellor Judith Jasper Leicht part of the Assembly Series Feb. 28,1991, of Physics and chair. Executive Editor Susan Killenberg McGinn Washington University, Campus Box 1070, when he gave an address in the Field House • Sept. 13: "Physics Underlying Medical News Editor Kimberly Leydig One Brookings Drive, St. Louis, M0 63130. Periodicals postage paid at St. Louis, M0. titled "Social Responsibility: Caring About ^xw tht Puna- Echocardiographic Imaging," Production Carl Jacobs Moral and Ethical Issues." He was the second James Miller, Ph.D., the Albert News & Comments Where to send address changes member of his family to speak as part of the Assembly Series; Gordon Hill Professor of Physics, (314) 935-6603 his wife, Rosalynn, spoke during the 1984-85 school year. The Campus Box 1070 Postmaster and nonemployees Record, professor of internal medicine and Washington University, Campus Box 1070, 2003 Assembly Series fall schedule kicks off with Columbia [email protected] of biomedical engineering. One Brookings Drive, St. Louis, M0 63130. University President Lee Bollinger speaking on "The • Sept. 20: "Magnetic Materials Medical News Employees Office of Human Resources, Foundations of the Principle of Academic Freedom" at 11 a.m. and Magnetic Information (314)286-0119 Campus Box 8508 Washington University, Campus Box 1184, Sept. 10 in Graham Chapel. For more information on the Storage," Stuart Solin, Ph.D., the Assembly Series, go to wupa.wustl.edu/assembly. [email protected] One Brookings Drive, St. Louis, M0 63130. Charles M. Hohenberg Professor of Washington University is celebrating its 150th anniversary in 2003-04. Special Experimental Physics. • Oct. 4: "Cosmic Rays," Martin programs and announcements will be made throughout the yearlong observance. 9 'VfehingtonUniversity in StLouis Israel, Ph.D., professor of physics: • Oct. llr "Ancient Stardust record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Aug. 29,2003 3 School of Medicine Update Epilepsy treatments may benefit from mouse model

BY GILA Z. RECKESS effective in and transmits messages from one treating TSC neuron to the next. With too Iost models of epilepsy and, poten- 'The model is therefore exciting for two reasons: much glutamate, neurons either focus on neurons, which tially, other It gives us an opportunity to understand become overly excited or die, M are the brain cells directly epilepsy disor- basic neurobiology and also to find more both of which can trigger responsible for seizures. But tar- ders. seizures. geting neurons with drugs is "This gives creative ways to treat patients." The group found that mice with astrocytes lacking TSC1 had often ineffective. us a rational MICHAEL WONG That's why School of Medicine target for abnormally low amounts of two researchers were excited to dis- seizures in glutamate transporters, Git-1 and cover that a type of support cell TSC and may GLAST, which are proteins re- in the brain, called an astrocyte, explain why sponsible for clearing glutamate also plays a critical role in the many medications fail," said Professor of Neurology. the first animal models of epilep- from synapses. Moreover, electri- development of epileptic seizures Michael Wong, M.D., Ph.D., assis- In the same way that a theatri- sy that results from a single gene cal recordings from these astro- in a mouse model of tuberous tant professor of neurology. "Re- cal performance has both actors defect; most models require toxic cytes revealed that the proteins sclerosis complex (TSC), a genet- searchers have not given much and an extensive support cast, injections or injury to induce were about 75 percent less ic disorder that affects about thought to the role of astrocytes neurons are considered to be epilepsy. active than in astrocytes from 50,000 Americans, more than half in epilepsy, so hopefully this the brain's "star" cells, with a In their latest study, the team normal mice. of whom experience frequent, model will act as a springboard to variety of support cells that began to decipher how a lack of "As we understand more about debilitating epileptic seizures. get people thinking about the help them function. While most TSC1 in astrocytes triggers neu- TSC1 in astrocytes, we gain The team's most recent study relationship between these cells epilepsy models focus on neu- rons to overreact, resulting in a insights into the relationship discusses the mechanisms by and seizure disorders." rons, Gutmann and his colleagues seizure. In particular, they between astrocytes and neurons," which these defective astrocytes These findings appear in the previously discovered that mice focused on one "housekeeping" Gutmann said. "The model is trigger seizures. If the findings August issue of the journal Annals whose astrocytes (a type of sup- role of astrocytes: removal of the therefore exciting for two reasons: also apply to humans, they could of Neurology. Wong led the study, port cell) lack a gene linked to chemical glutamate from synaps- It gives us an opportunity to suggest that current drugs that in collaboration with David TSC called TSC1 developed es, the spaces between neurons. understand basic neurobiology affect levels of a brain chemical H. Gutmann, M.D., Ph.D., the epileptic seizures. Glutamate is the main brain and also to find more creative called glutamate could be more Donald O. Schnuck Family The model represents one of chemical that activates neurons ways to treat patients." Mutation might cause acute myeloid leukemia

BY DARRELL E. WARD Normally, these molecules are carefully regulated to keep a tight School of Medicine researchers lid on cell growth. But they can have found that a chromosome lose that regulation when tyrosine defect often seen in human acute kinase genes mutate. For example, myeloid leukemia (AML) can instead of powering reactions cause the same disease in mice only when appropriate, the tel- when combined with a genetic pdgfrb protein runs constantly, defect in a molecule known as a like an engine that won't shut off. tyrosine kinase receptor. "Mutations in tyrosine kinases The study appeared online and can push cells to divide," Griso- in the Aug. 5 issue of the Proceed- lano said. "If this is combined ings of the National Academy of with a mutation that blocks Sciences. cells from maturing, as does "The findings indicate that the amll-eto gene, it can lead tyrosine kinases may be an impor- to cancer." tant class of cancer-causing genes For example, mutations in a in leukemia," said principal inves- gene known as flt3 (also in the tigator Michael H. Tomasson, tyrosine-kinase gene family) are M.D., assistant professor of genet- among the most common muta- ics and of medicine. "It further tions in people with AML. Drugs suggests that drugs designed to that block flt3 are being developed inhibit these molecules might pro- as a possible treatment for AML. DialySIS dynamOS Former renal division directors Saulo Klahr, M.D. (left), the John E. and vide effective new treatments for Tel-pdgfrb is closely related to flt3. Adaline Simon Professor of Medicine, and Neal Bricker, M.D., the first director of the renal division this deadly disease." "This study further supports when it was founded in 1956, flank current Director Marc Hammerman, M.D., the Chromalloy AML is a cancer of immature the idea that tyrosine kinases Professor of Renal Diseases in Medicine. The physicians are discussing the remarkable progress white blood cells. It can lead to may be highly worthwhile targets made in dialysis services at the University at a celebration honoring five decades of nephrology, severe anemia and immune defi- for new drugs to treat AML," held earlier this summer in conjunction with the opening of the newly relocated Chromalloy ciency and often is fatal. Although Tomasson said. Kidney Center. AML accounts for less than 3 per- cent of all cancers, it is the leading cause of cancer death among Americans under age 35. It also Liver plays key role in how steroids cause diabetes, hypertension strikes older people, in whom it BY GILA Z. RECKESS Nature Medicine. Bernal-Mizrachi LDLR had increased levels of production tripled. can be difficult to treat. led the study, in collaboration insulin and fasting glucose and "The scientific community About 12 percent of AML Steroids called glucocorticoids with Clay F. Semenkovich, M.D., leptin — all signs of diabetes. hasn't fully appreciated the patients have a chromosomal are critical for treating afflic- professor of medicine and of cell The animals also became less potentially important role of abnormality that fuses a piece of tions such as asthma, arthritis and biology and physiology and direc- hypoglycemic when given the liver in these conditions," chromosome 21 to chromosome pain syndromes, but they also can tor of the Division of Endo- insulin, suggesting that they were Semenkovich said. "These results 8. The genetic mutation leads to trigger diabetes and hypertension. crinology, Metabolism and Lipid developing insulin resistance, the strongly suggest that the liver is production of an abnormal pro- School of Medicine research now Research; and Daniel P. Kelly, precursor to diabetes. Mice lack- the key to controlling blood tein known as amll-eto. But this reveals why these commonly used M.D., professor of medicine, of ing both LDLR and PPAR-alpha pressure and glucose, and our change alone isn't enough to cause drugs have such dangerous side molecular biology and pharma- showed no signs of diabetes. preliminary evidence with AML in humans or animals. effects. cology and of pediatrics and Surprisingly, dexamethasone human liver cells strongly sug- Tomasson and his colleagues The team found that a protein director of the Center for also increased blood pressure in gests that the results in mice are examined mice transplanted with called peroxisome proliferator- Cardiovascular research. mice that had PPAR-alpha but relevant to human disease." bone marrow cells, some of which activated receptor-alpha (PPAR- Hypertension (persistent high not LDLR; it did not have an Next, Semenkovich, Bernal- contained both the amll-eto alpha) is critical in this process blood pressure) and diabetes effect on blood pressure in mice Mizrachi and their colleagues defect and a defect in a tyrosine and that the liver plays a key role. (chronic insulin deficiency) both lacking both PPAR-alpha and plan to investigate the role of kinase receptor gene known as tel- The findings help explain the high are related to insulin-resistance. LDLR. PPAR-alpha in healthy humans. pdgfrb. With these two mutations, incidence of diabetes and hyper- PPAR-alpha is found in the "Somehow animals missing "We believe that diabetes, the mice developed AML; mice tension in obese individuals, a liver, kidney, muscles, blood ves- PPAR-alpha were protected from hypertension and many other with only the amll-eto fusion gene group that normally produces sig- sels and other organs. Because it developing diabetes and hyper- disorders of Western civilization did not develop the disease. nificantly more glucocorticoids is activated by fatty acids and tension," Semenkovich said. are related to metabolism of "This is the first study to show than people of average weight. because glucocorticoids alter The team then replaced fatty acids, not just glucose that an activated tyrosine kinase "Glucocorticoids are very fatty acid processing, Bernal- PPAR-alpha mice livers lacking metabolism," Semenkovich said. receptor can cooperate with amll- effective for treating many dis- Mizrachi and his colleagues both PPAR-alpha and LDLR. "These results support that theo- eto to produce AML in laboratory eases," said first author Carlos hypothesized that the two may The animals developed the ry because PPAR-alpha is activat- animals," said first author Jay L. Bernal-Mizrachi, M.D., instructor act together to produce the dis- same symptoms of diabetes ed by fatty acids and appears to Grisolano, Ph.D., a postdoctoral of medicine. "If we can under- ease-causing side effects. and hypertension when chroni- be important in the development fellow in Tomasson's laboratory. stand the mechanisms by which They therefore compared cally treated with dexametha- of these problems. "It raises the possibility that a these drugs cause side effects like mice lacking PPAR-alpha and sone as mice with normal Hopefully, studying this combination of therapies designed diabetes and hypertension, we LDLR (the receptor for low den- levels of PPAR-alpha through- process in humans will lead to to inhibit amll-eto and tyrosine may be able to intervene and pre- sity lipoprotein, also known as out the body. ways of preventing these poten- kinase receptors might one day be vent these disorders in people "bad cholesterol") with mice The team also examined tially adverse effects of steroids used to control this disease." who are taking steroids and in lacking only LDLR. human liver cells in a petri dish. and help us understand why Tyrosine kinases power chemi- people who are obese." The team found that when When PPAR-alpha was activated overweight people have many of cal reactions in cells, particularly The study appeared online and given the glucocorticoid dexam- and steroids were added, expres- the symptoms of excess produc- those involved in cell division. in the August issue of the journal ethasone, mice lacking only sion of genes related to glucose tion of glucocorticoids." 4 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS University Events Chinese Ceramics Name Changing

"University Events" lists a portion of the P. Newman Education Center. To register, activities taking place at Washington call 362-6891. University Aug. 29-Sept. 11. Visit the Web for expanded calendars for the Hilltop Saturday, Sept. 6 Campus (calendar.wustl.edu) and the 10 a.m. Physics Science Saturdays School of Medicine (medschool. wustl Lecture Series. "The Second Quantum .edu/calendars.html). Revolution." John Clark, prof, of physics. Crow Hall, Rm. 201. 935-6276. Exhibits Sunday, Sept. 7 Noon-9 p.m. Sesquicentennial Biology Seminar Series. "Moss 2003: Recent History of Adult Education at Washington Advances in Genetics, Molecular Biology, University, 1854-2004. Through May and Development." (Also 8:30 31. January Hall, Rm. 20. 935-4806. \a.m.-9:30 p.m., Sept. 8, 9 a.m.-9 Chinese Ceramics Today. Sept. 5arsy p.m. Sept. 9, 9 a.m.-2 p.m. Sept. 5-0ct. 3. Des Lee Gallery, 1627 y 10.) Donald Danforth Plant / Washington Ave. 935-4643. Science Center. For times, costs and to register, call 935-6860. Influence 150:150 Years of Shaping a City, a Nation, the World. Sept. 5-Dec. 7. Gallery Monday, Sept. 8 of Art. 935-4523. 9-10 a.m. Funding Resources Seminar. Inscriptions of History/ "Funding Resources for New Medical Topographies of Time: The School'Faculty." Bernard Becker Medical Photographs of Alan Cohen. Library, Rm. 601B. 935-4119. Sept. 5-Dec. 7. Gallery of Art. Noon. Molecular Biology & Pharmacology 935-5423. Seminar. "Role of RNA Stability and Translational Control in the Regulation of Apoptosis." Shrikant Anant, asst. prof, of medicine. South Bldg., Rm. 3907, Philip Lectures Needleman Library. 362-0183. Noon. Center for the Study of Nervous Friday, Aug. 29 System Injury Lecture. "Cellular Inorganic Chemistry and the Neurobiology of 9:15 a.m. Pedialric Grand Rounds. "Dr. Disease." Jonathan D. Gitlin, Helene B. McCoy Meets Stanley Kubrick: The Roberson Professor of Pediatrics and dir., This Scotch elm at the southeast end of Brookings Hall is benefiting from a series of braces to ease Intersection of Ethics and Medical pediatric immunology & rheumatology. Informatics." Barry P. Markovitz, assoc. Maternity Bldg., Schwarz Aud. 362-9460. the stress on the limbs. A storm in September 2001 nearly split the approximately 90-year-old tree. prof, of anesthesiology. Clopton Aud., 4950 Children's Place. 454-6006. 5:30 p.m. Radiology Lecture. Annual G. Leland Melson Visiting Professorship and Lecture. "Multislice CT: Radiation Dose Tuesday, Sept. 2 Considerations and Future Directions." Scotch elm making comeback Noon. Alzheimer's Disease Research James A. Brink, prof, and interim chair of Center Tuesday Conference Seminar radiology, head of abdominal imaging, BY ANDY CLENDENNEN growing, healing its wound, and Series. "Association of Reported Yale U. Scarpellino Aud., 510 S. right now I don't think we have Depression and Cognitive Performance Kingshighway Blvd. 362-2866. After going through some "A lot of people weren't anything to be worried about. in Dementia." Kim Powlishta, asst. prof, 6 p.m. Architecture Monday Night Lecture rough times, the popular of developmental psychology, St. Louis sure about it, but two Which isn't to say it can't take a Series. "Beyond Design: Women's Center Scotch elm at the southeast turn for the worse, but right U., and Martha Storandt, prof, of psy- in Senegal." Jenni Reuter, architect, chology. Barnes-Jewish Hosp. Bldg., Sandmen Reuter & Hollmen Architects, end of Brookings Hall has weath- years later it seems to now it's doing well." East Pavilion Aud. 286-2881. Helsinki, Finland. (5:30 p.m., reception.) ered the storm — literally — and be doing quite well and The braces in place are per- Steinberg Hall Aud. 935-6200. appears to be coming through manent, as there are signs of Wednesday, Sept. 3 with flying green colors. it appears it was money failure in the crotch of each of 11 a.m. Public Interest Law Speakers Tuesday, Sept. 9 In September 2001, strong well spent. It's actively the branches. However, the Series. "Multiculturalism, Reparations, Noon. Alzheimer's Disease Research winds came through and almost braces have been erected in such and the Politics of Memory." Gerald L. Center Tuesday Conference Seminar. split the approximately 90-year- growing, healing its a way as to not compromise the Early, Merle Kling Professor of Modern "Report on NAAC Study of Aging and Mild Letters. Anheuser-Busch Hall, Bryan old tree in half at the base. wound, and right now I integrity of the tree. AD Cases from 7 Alzheimer Centers." Joel Horticultural manager Paul "If we didn't do anything, Cave Moot Courtroom. 935-4958. Price, prof, of anatomy & neurobiology. don't think we have 4 p.m. University Libraries Lecture. Barnes-Jewish Hosp. Bldg., East Pavilion Norman met with some others to the branch could break off and "Five Centuries of Judeo-Spanish." Gad Aud. 286-2881. determine the best course of anything to be worried strip down the side of the tree, Nassi, editor. Olin Library, Lvl. A, ARC Noon. Program in Physical Therapy action — try and save the tree, or causing more severe problems," Presentation Room. 935-8179. Research Seminar. JoAnne Wagner, doc- leave it alone because it wasn't about. Which isn't to Norman said. "But the braces toral student in movement science. 4444 worth the time, effort and say it can't take a turn are hidden, especially when the Thursday, Sept. 4 Forest Park Blvd., Rm. B112. 286-1404. money. tree is in leaf, and we can move 2-4 p.m. Lifelong Learning Institute Fall 7 p.m. Remembering 1853: A Sesqui- They gave reviving the tree a for the worse, but right them because they aren't Address. "Why Does the U.S. Govern- centennial Celebration of the shot. After hauling away some now it's doing well." attached to the tree - the limbs ment Object to the International Humanities. "Music in 1853: New dead wood and lessening the , Starts for Berlioz, Wagner and are sitting on a support similar Criminal Court?" Leila Nadya Sadat, PAUL NORMAN prof, of law. Gallery of Art. To register, ) Brahms." Hugh MacDonald, Avis weight of some branches, they to a cradle. call 935-4237. Blewett Professor of Music. built a series of braces to ease the "I don't see us having a McDonnell Hall, Rm. 162. 935-6759. 4 p.m. Chemistry Seminar. "Molecular stress on the limbs. chance at removing the braces Recognition of DNA by Small 8 p.m. Writing Program Reading Series. And nearly two years later, the about it, but two years later it completely, but we might move Molecules." Peter B. Dervan, Bren "Ireland: A Case of Masked Modernity?" tree appears to be back on solid seems to be doing quite well and them to avoid some wear on the Professor of Chemistry, Cal. Inst. of Declan Kiberd, prof, of Anglo-Irish lit. and ground. it appears it was money well branches caused when the wind drama, U. College, Dublin. Duncker Hall, Technology. (3:15 p.m., reception, Lab "A lot of people weren't sure spent," Norman said. "It's actively Sciences Bldg., Rettner Gallery.) Lab Rm. 201, Hurst Lounge. 935-7130. blows." Sciences Bldg., Rm. 300. 935-6530. 4:15 p.m. Earth & Planetary Sciences Wednesday Sept. 10 "Access to Justice" speaker series presented by law school Colloquium. "Mantle Convection With 11 a.m. Assembly Series. SchooSchool of Law r * * / Realistic Rheologies." Viatcheslav Sesquicentennial Lecture. "The (Slava) Solomatov, assoc. prof, of I Foundations of the Principle of BY JESSICA MARTIN the Lemma Barkaloo & Phoebe the University of Michigan, and physics, N.M. State U. McDonnell Hall, Academic Freedom." Lee Couzins Professor of Law, coor- the respondent in the affirmative Rm. 362. 935-5610. Bollinger, pres. and prof, of law, The respondent in the U.S. dinate the series. action cases of Grutter v. Bollinger Columbia U. Graham Chapel. 935-5285. Friday, Sept. 5 Supreme Court affirmative The fall lectures will all be and Gratz v. Bollinger. This 4:30 p.m. Physical Therapy Professional action cases Grutter v. Bollinger held in Anheuser-Busch Hall address is co-sponsored by the Conclave. Debbie McDonnell, instructor in 1 p.m. Chemistry Lecture. "Regulation of and Gratz v. Bollinger and a mem- unless otherwise noted and are Assembly Series and also is the law Gene Expression by Synthetic Ligands." physical therapy. 4444 Forest Park Blvd., Peter B. Dervan, Bren Professor of Rm. B108/B109. 286-1406. ber of the American Society on free and open to the public. school's Sesquicentennial Lecture. Chemistry, Cal. Inst. of Technology. International Law's executive They are: • 12 p.m. Nov. 13 — Amy L. Whfttaker Hall, Rm. 100. 935-6530. Thursday, Sept. 11 counsel are part of the fall lineup • 11 a.m. Sept. 3 — Gerald Chua, professor of law at Yale for the School of Law's sixth annu- L. Early, Ph.D., the Merle Kling 2:30-6:30 p.m. Siteman Cancer Center 8 p.m. Writing Program Reading Series. University and member of the CME Conference. "Second Annual "The City in Irish Writing." Declan Kiberd, al Public Interest Law Speaker Professor of Modern Letters in American Society of International Colorectal Conference." Cost: $35. Eric prof, of Anglo-Irish lit. and drama, U. Series. Arts & Sciences and director of Law's executive council, will dis- College, Dublin. Duncker Hall, Rm. 201, This popular series, titled The Center for the Humanities cuss "How Exporting Free Markets How to submit Hurst Lounge. 935-7130. "Access to Justice: The Social (formerly International Writers and Democracy Breeds Ethnic Responsibility of Lawyers," was Center), will address "Multi- Hated and Global Instability." 'University Events' initiated to highlight the excellence culturalism, Reparations and Chua is the past consultant for the And more... of the law school's Clinical Edu- the Politics of Memory." Early is American Bar Association's Submit "University Events" items cation Program; to expose stu- the author or editor of numer- Section of International Law and to Genevieve Podleski of the dents to public interest advocates ous books, including This Is Practice and for its Central and Record staff via: Tuesday, Sept. 2 and practitioners; to illuminate the Where I Came in: Essays on East European Law Initiative. (1) e-mail — record_calendar 4 p.m. Name-Changing Ceremony. The pro bono and public interest Black America in the 1960s. This speaker series will contin- International Writers Center becomes The ©aismail.wustl.edu; responsibility of law students and • 11 a.m. Sept. 10 in Graham ue in the spring with seven lec- Center for the Humanities, Dedicated to (2) campus mail — Letters and Humanistic Research and lawyers; and to engage the wider Chapel — Lee C. Bollinger, tures. Campus Box 1070; or Their Presence in the Public Life. University community in an inter- president and professor of law at One mandatory continuing (3) fax — 935-4259. Women's Bldg. Formal Lounge. 935-5576. disciplinary discussion about Columbia University, will speak legal education credit can Deadline for submissions is social justice. on "The Foundations of the be earned by attending each noon on the Thursday eight days Thursday, Sept. 11 Karen L. Tokarz, J.D., professor Principle of Academic Free- lecture. prior to the publication date. 7 p.m. 9/11 Memorial Gathering. of law and director of clinical edu- dom." Bollinger is the former For more information, call Brookings Quadrangle. 935-5022. cation, and Susan F. Appleton, J.D., president and law school dean at 935-4958. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Aug. 29,2003 5

Search committee members

Chancellor Mark S. Wrigh- Ollie, Ph.D. candidate; M. ton has appointed Enola E. Heliana Ramirez, master of Proctor, Ph.D., the Frank J. social work student; Estelle Bruno Professor of Social Work Rochman, director of the Research, to chair a 14-mem- Office of Field Education; ber dean search committee. Michael Sherraden, Ph.D., Wrighton also named the fol- the Benjamin E. Youngdahl lowing individuals to the com- Professor of Social Devel- mittee: opment; Martha Storandt, John C. Bricout, Ph.D., Ph.D., professor of psychology assistant professor of social in Arts & Sciences; Gautam N. work; Diane E. Elze, Ph.D., Yadama, Ph.D., associate pro- assistant professor of social fessor of social work; Luis H. work; Matthew O. Howard, Zayas, Ph.D., the Shanti K. Ph.D., associate professor of Khinduka Distinguished Pro- social work; Nancy L. fessor of Social Work; and Morrow-Howell, Ph.D., pro- Charles F. Zorumski, M.D., fessor of social work; Sima the Samuel B. Guze Professor Needleman, a 1974 alumna and chair of the Department and member of the GWB of Psychiatry in the School of National Council; Marcia T. Medicine.

agencies. The school has also substan- GWB dean tially increased its endowment; School has grown under established a number of named Among our many outstanding freshmen is Kari Sufficool, from Lincoln, Neb. She was honored as one professorships for faculty; greatly of 25 nationwide winners of the "Milk Mustache" campaign's Scholar Athlete Milk Mustache of the Year Khinduka's leadership award. Sufficool was chosen from a record 52,000 applicants by a panel of Milk Mustache star athletes. expanded the number of scholar- - from Page 1 Sufficool was selected for her outstanding achievements in academics, athletics, community service ships for students; broadened and and leadership. As part of her award, she will receive a $7,500 college scholarship and a spot in her deepened its programs of inter- own milk ad. In addition to being at the top of her class, Sufficool was on the volleyball, tennis and remarkable growth of the disciplinary collaboration; and state champion basketball teams in high school. She also volunteered with the Special Olympics and research portfolio of the social houses the largest number of tutored at a local elementary school. work faculty; development of an international students in any U.S. innovative curriculum; and estab- social work school. lishment of a unique program of Wrighton plans to have new capacity building for St. Louis leadership in place by July 1. Class of 2007 is rich in talent, diversity

BY ANDY CLENDENNEN Many in the select group were • In athletics, 375 were team academic leaders, officers in stu- captains. Stepping onto a college cam- dent government and participants "It is a delight to have such a Sports pus for the first time as an in extracurricular activities and talented and diverse freshman actual student can be a athletics in high school. Collec- class on campus," said Nanette H. daunting experience for anyone. tively, the incoming class has Tarbouni, director of undergrad- But if anyone can handle this received almost 2,200 special uate admissions. "We encourage stressful transition, the students awards and recognitions. In ad- everyone to extend a warm wel- who make up the University's dition: come to them." Class of 2007 can. • About 845 students are In addition to accumulating The approximately 1,375 first- National Honor Society members; impressive statistics during their year students hail from all over • 170 were senior class officers, high-school years, the freshmen the world and represent approxi- and 337 were officers in service were chosen from a record num- mately 20 countries, 50 states, organizations; ber of applicants — more than the District of Columbia and • Many served as editors — 20,000. Puerto Rico. They arrived Aug. 21 93 of yearbooks and 135 of news- "We are excited that so many and have been busy unpacking, papers; students chose to come to learning their way around the • Musically, 323 were members Washington University," Tarbouni Hilltop Campus and gearing up of their school bands or orches- said. "That is quite a compliment for the fall semester, which began tras and 211 were members of a to the Washington University Aug. 27. choir or chorus, and; community."

of which carry many genes. large segments of DNA with Sequencing proceeded from each many duplicated genes, and the Chromosome end toward the centromere. number of duplicated genes dif- Largest human one so far The centromere itself contains fers among individuals. Children many short, repetitive DNA with WBS are missing long sequenced by researchers sequences and few, if any, genes. stretches of these duplicated - from Page 1 "We got in close to the cen- genes. tromere and characterized those "It seems that multiple copies cell death, genes for taste and repeat sequences for the first of these genes are necessary for smell receptors and those time," Wilson said. normal development, and if any involved in immune responses. The most challenging region of are lost, developmental abnormal- Chromosome 7 also has a rela- the chromosome to sequence was ities occur," Wilson said. "People tively centrally located cen- the area that contains genes for who study this disease may find tromere, a small region found on Williams-Beuren syndrome the chromosome 7 sequence data all chromosomes that is impor- (WBS), a rare genetic disorder very helpful." tant during cell division. Centro- characterized by mild mental Next, Wilson and his col- meres on other chromosomes retardation, unusual facial appear- leagues will re-sequence certain sequenced so far are located near ance and a narrowing of the genes on chromosome 7 from the tip of the chromosome. aorta, the major artery leaving the people with acute leukemia to The centromere on chromo- heart. better understand the genetic some 7 divides the chromosome The WBS region was difficult changes that give rise to the into a short and long arm, both to decipher because it contains malignancy. Employment

Go online to hr.wustl.edu (Hilltop Campus) or medicine.wustl.edu/wumshr (Medical Campus) to obtain complete job descriptions. Senior Cindy McPeak and the WUSTL volleyball team will begin the season ranked No. 1 in NCAA Division III, earning the top spot in Director, Student Hazardous Materials Public Safety Officer Secretary II 040181 040163 the American Volleyball Coaches Association Top 25 preseason poll. Hilltop Health & Counseling Tech II 040033 Medical Coord., Laboratory Service 030222 Circulation Assistant User Support Support Services Campus Internship Specialist 040035 Campus Analyst II 040164 040182 Wisconsin-Whitewater is fourth This is a partial list of Bears volleyball opens For the most current 030332 General Services Programmer Analyst Medical Secretary III listing of Hilltop positions in the with 335. California State Business Assistant 040036 040165 040183 Campus position open- School of Medicine. season ranked No. 1 Development Staff Scientist Grants/Budget University, Hayward, rounds out ings and the Hilltop Employer Relations Employees: Contact Specialist 030334 040168 Specialist 040186 With five of six starters back from the top five with 321 points. Campus application Coordinator 040037 the medical school's process, go online to Senior Research Head Men's & Office of Human Research Associate Secretary I 040187 a team that is the reigning nation- Washington U went 41-2 in Assistant 030337 Resources at hr.wustl.edu. For more Women's Track & 040170 Coord., Medical al runner-up, the University's vol- 2002, falling one win shy of win- 362-7196. External information, call Administrative Field Coach 040038 Dietitian (Part Coding 040191 candidates: Submit leyball team was voted No. 1 in ning an NCAA Division Ill- 935-5906 to reach the Assistant 040006 Time) 040171 Human Resources Mail Services Carrier resumes to the Office Building Coord. the 2003 American Volleyball record eighth national champi- Employment Office at 2nd Assistant Crew And Operator 040039 of Human Resources, Research 040192 Coach 040003 Technician 040173 Coaches Association Top 25 pre- onship. The Bears made their West Campus. Admin. Asst., 4480 Clayton Ave., Medical Secretary II season poll. 16th NCAA Tournament appear- Margins Office Editorial Office. Campus Box 8002, Patient Billing 040193 Coordinator 040007 040040 St. Louis, MO 63110, Services Rep. General Lab Medical Secretary I The Bears tallied 388 points ance last season after winning or call 362-7196. 040177 Assistant-Part Time Accounting Assistant Project Coord. 040194 in the poll, including eight first- their 14th straight University 020237 040021 040041 Research Research Admin. Coord. Technician I Technician I—Part place votes, putting them 19 Athletic Association title. Registered Nurse Admissions Fixed Asset 040080 040196 030079 Counselor 040025 Accountant 040042 Time 040178 points ahead of second-ranked WUSTL opens this season RN—Research Sr. Research Animal Care Juniata College. Trinity University Aug. 29-30 at the Elmhurst Associate Director Of Lab Technician IV Dispatcher-Clerk Technician 040151 Patient Coord. Capital Projects 040027 040043 Technician II 040197 (Texas) is ranked third with 356 Invitational in Elmhurst, 111. The 030203 Nurse Practitioner 040179 Earth & Planetary Parking Enforcement 040152 points, and defending national Bears begin the tournament Deputized Police Sciences Library Monitor 040044 Supervisor, Patient champion University of against Hope College. Officer 030217 Assistant 040029 RN Staff Nurse Accounts 040180 Radiation Safety 040159 Specialist I 040045 6 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS

END Of CUPPLES BUILDING EAST FRONT BROOKINGS BUILDING

TRACING OF COfE AND STEWARDSON COMPETITION DE5IGN FOR WASHINGTON UNIVERSITY 1900

An 1899 site elevation of Brookings Hall, by Cope and Stewardson, a Philadelphia architectural firm that had designed similar campus buildings at Princeton University and other campuses. The 5-foot drawing is part of Influence 150:150 Years of Shaping a City, a Nation, the World, at the Gallery of Art Sept. 5-Dec. 7.

ductions, led by Jill Silverstein.) Harriet Hosmer's on the Prize; poet laureates "Some of these are fairly well marble Oenone Howard Nemerov and Mona Van Exhibition known, such as the 1904 World's (1854-55) also is Duyn; and Al Parker, the "dean of Opens with reception Fair and the presidential debates part of the American illustrators," who pio- in 1992 and 2000. Others, equally Influence 150 neered the bold, graphic look of Sept. 5 at Gallery of Art fascinating and dramatic, will exhibition. fashion monthlies in the 1940s, - from Page 1 likely surprise many visitors." Hosmer was the '50s and '60s. Examples of both can be first woman to A section on T.S. Eliot, grand- study anatomy at technology and dean of found in the tenure of Robert son of William Greenleaf Eliot, Brookings, chairman of the Board what would features a rarely seen student University Libraries. "The first become the is the role of the university in of Trustees from 1895-1928, who poem. Tennessee Williams is rep- spearheaded creation of the pres- School of resented by a typescript of Me urban American society — that Medicine and ent Hilltop Campus. Vashya, a 1936-37 student work, is, how Washington University one of the few and St. Louis have each con- Highlights of the exhibition successful among other materials. tributed to the growth and devel- include a striking, four-foot woman artists of Lower galleries survey the opment of the other. drawing of the original, 1895 her day. University's nationally acclaimed "The second is the influence of campus plan by Frederick Law art collection, which dates back to Washington University as a mod- Olmstead, who also designed COURTESY PHOTO 1881, when Crow and a young ern, international institution, and New York's Central Park; and a professor named Halsey C. Ives the individuals and groups — five-foot, 1899 drawing of women, the influence of Euro- Other displays chronicle some established the St. Louis School chancellors, scholars, immigrants, Brookings Hall, by the Philadel- pean refugees and the welcoming, of the University's major scien- and Museum of Fine Arts, the women — who have helped to phia firm Cope and Stewardson. during World War II, of Japanese- tific achievements, from the first art museum west of the shape its identity and reputation." Brookings famously leased the American students from intern- founding of the School of Mississippi River. newly completed campus to ment camps." Medicine in 1891 to its current Highlights range from early, Exhibition organization World's Fair organizers, using Phoebe Couzins, who enrolled role in decoding the human iconic images of the American The main, upstairs gallery will proceeds to fund additional con- in the School of Law in 1869 — genome. West, such as George Caleb feature archival photographs, struction, including Francis Field, just two years after its founding Profiles include Nobel Prize- Bingham's Daniel Boone Escorting drawings, posters, letters, scrap- site of the third World Olympiad — later helped found the Nation- winning physicist Arthur H. Settlers Through Cumberland Gap books and other materials illus- (the first Olympics ever held in al Woman Suffrage Association. Compton, a leader of the (1851-52) and Carl Wimar's The trating more than 150 individual the Western Hemisphere). Less Famed art historian H.W Janson, Manhattan Project; Evarts A. Buffalo Hunt (1860) to modern displays on notable faculty and familiar, however, is Brookings' author of the influential textbook Graham and Ernst L. Wynder, masterworks by Pablo Picasso, alumni, their major achievements 1917 launch of a graduate study History of Art, left Hitler's Ger- who in 1953 established a clear Jackson Pollock and Willem de and broader topics such as the program in St. Louis and Wash- many in the mid-1950s and sub- link between lung cancer and Kooning. evolution of campus life. ington, D.C. — a program that sequently established the Gallery cigarettes; and Harold Rosenthal, Gallery of Art hours are "We wanted to present a bal- would eventually spawn the of Art's nationally renowned whose St. Louis Baby Tooth 10 a.m.-4:30 p.m. Tuesday ance of stories," said Baker, who world-famous Brookings Institu- modern collection. Survey (1959-1970) revealed through Thursday; 10 a.m.-8 p.m. chaired a 10-member exhibition tion "think tank." Gyo Obata, who avoided a long-term effects of nuclear Fridays; and noon-4:30 p.m. committee that included faculty Utah internment camp by enrol- fallout. weekends. The Gallery of Art is historians, curators and arch- Profiles, personalities ling in the School of Architecture, Other profiles include film- closed Mondays. ivists. (The committee also Some of the University's co-founded Hellmuth, Obata + maker Henry Hampton, best The exhibit is free and open to worked with an exhibit design proudest moments, Baker said, Kassabaum, one of the world's known for the groundbreaking the public. For more information, team from BlueRoad Pro- involve "the early entrance of largest architecture firms. Civil Rights documentary Eyes call 935-4523.

dards Board and has been widely Clinton administration. During "Humanity's Genes," Sydney prodigy who received a doctorate sought by the media for his her tenure, landmark legislation Brenner, a 2002 Nobel laureate, from the California Institute of Series insights into the recent account- such as the Food Quality Pro- will consider the implications of Technology at age 20, he was also Mendelsohn to close ing scandals. tection Act and the Safe Drinking this new knowledge. the youngest to win a Mac- In 1998, social critic Barbara Water Act were passed. Brenner is president and direc- Arthur Foundation "genius" fall schedule Nov. 13 Ehrenreich decided to find out Writer and essayist Richard tor of the Molecular Sciences grant. - from Page 1 firsthand what it's like to live on a Rodriguez will deliver the Institute, and he is a distingu- In 2002, Wolfram published A minimum-wage salary. Two years Association of Latin American ished research professor at The New Kind of Science, in which he In June 2002, Bollinger re- and six unskilled jobs later, Nickel Students' annual lecture Oct. 8. Salk Institute. His talk, the annual challenges scientific orthodoxy, turned to Columbia University ' and Dimed: On (Not) Getting by His talk, "The Browning of Arthur Holly Compton Lecture, especially in the areas of com- to become the 19th president. in America was published and America," will be based on his will be at 4 p.m. Oct. 14. plexity and computational Thomas Friedman will pres- became a best seller. Her talk, most recent book, Brown: The The speaker for the Oct. 15 processes. His invention, ent "What Kind of International "Walking the Poverty Line," will Last Discovery of America, which lecture will be announced at a "Mathematica," has been hailed Borders Will Exist in the 21st be Oct. 1 as the annual Olin explores his perspectives on the later date, and there is no lecture as one of the most important Century?" Sept. 17 in the Athletic Fellows Lecture. "Latinization" of American cul- Oct. 22. pieces of scientific software ever Complex. Friedman is a three- One of the hallmarks of the ture. In his first two books, Rod- Veteran comedian and activist written. time Pulitzer Prize-winning jour- University's 150th commemora- riguez details his life growing up Dick Gregory will be this year's The annual Elliot Stein nalist, author and renowned tion is a multipronged initiative in a Mexican-American family Black Arts & Sciences Festival Memorial Lecture will be pre- expert on Middle East issues. focusing in-depth on the role of bent on total assimilation. keynote speaker Oct. 29. sented by Mark Malloch Brown At 2 p.m. that day, Friedman research universities in addressing The second Environmental The first African-American Nov. 12. will kick off Arts 8c Sciences' environmental issues. The Envi- Initiative colloquium will be held humorist to gain mainstream In his capacity as chief admin- major Sesquicentennial project ronmental Initiative will help at 3 p.m. Oct. 9 and will feature popularity, Gregory also is well istrator of the UN. Development called "Conversations" when he shape the educational programs, two prominent scientists, Jane known for his role in the Civil Programme, Malloch Brown over- joins other distinguished pan- research and operations of the Lubchenco and Mario Molina. Rights movement, and he has sees UN. development efforts in elists in Graham Chapel. They institution and will be used to Lubchenco is a professor of been involved in many other 166 countries. He is leading the will continue the "conversation" define environmentally related marine biology at Oregon State human rights concerns. He con- United Nations in its goal of on international borders. future programs. University and is engaged in a tinues today as a strong voice for reducing extreme poverty by half For information on this panel The first of two colloquia is wide range of activities to help a range of human rights issues. in the next 10-15 years. discussion and subsequent ones scheduled for 3 p.m. Oct. 3. Two advance the frontiers of environ- Adam Hochschild will deliver The fall series concludes planned throughout the year, go of the most widely respected for- mental sciences. She is the recipi- the annual Holocaust Lecture Nov. 13 with the annual Thomas online to artsci.wustl.edu/ mer directors of the Environ- ent of the 2002 Heinz Prize in the Nov. 5. His talk is titled "The Hall Lecture featuring Everett conversations. mental Protection Agency, Carol Environment and a MacArthur Holocaust in the Congo — Then Mendelsohn, whose talk is titled Eminent economist and for- Browner and William Reilly, Foundation "genius" grant. and Today." "Dolly and the Historians: Sci- mer Federal Reserve System will consider and discuss the Molina is a professor of chem- In his most recent book, King ence, Politics and Ethics of chairman Paul Volcker will de- political, social and humanistic istry and a professor of earth, Leopold's Ghost, Hochschild gives Cloning." An eminent historian liver the Olin School of Busi- concerns regarding the envi- atmosphere and planetary sci- a spellbinding account of the of science at Harvard University ness Sesquicentennial Lecture ronment. ences at the Massachusetts Insti- nearly forgotten genocidal crimes whose career spans four decades, Sept. 24. His career covers both Reilly was appointed EPA ad- tute of Technology. He received a of the late 19th and early 20th his research interests focus on public service and private prac- ministrator in 1989 by President Nobel Prize in 1995 for his work centuries in what was the Belgian aspects of the social and sociolog- tice and spans five decades and George Bush, overseeing, among on polar ozone depletion. Congo. The New York Times has ical history of science and the five presidents. other significant environmental It's common knowledge that honored his book as a Notable relation of science and modern He was appointed Fed chair- concerns, the Exxon Valdez oil the Human Genome Sequencing Book of the Year. societies. man by President Jimmy Carter spill cleanup. Project has been completed, but Stephen Wolfram, scientist For more information on and held the position for eight Browner succeeded Reilly as what this new knowledge means and innovator in computing and Assembly Series events, go online years. Volcker now heads the EPA chief in 1993 and served in to the average person is far from software technology, will give a to wupa.wustl.edu/assembly, or International Accounting Stan- this capacity throughout the being understood. In his lecture, presentation at 4 p.m. Nov. 6. A call 935-5285. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Aug. 29,2003 7 Notables Promotions, tenure received by faculty At the Board of Trustees • Todd T. Milbourn to associ- meetings held Dec. 6, 2002, ate professor of finance March 7 and May 2, the fol- • Hector D. Molina-Vicenty to lowing faculty members were associate professor of medicine granted tenure or promoted with • Marc R. Moon to associate tenure effective July 1, 2003, professor of surgery (cardiotho- unless otherwise noted. racic surgery) (March 7) • Elliot C. Nelson to associate Promotion with tenure professor of psychiatry (Jan. 1) • Mary Jo Bang to associate • Arie Perry to associate profes- professor of English in Arts & sor of pathology and immunology Sciences • R. Keith Sawyer to associate • Deanna M. Barch to associ- professor of education in Arts & ate professor of psychology in Sciences Arts & Sciences • Jean Elise Schaffer to associ- • Monica Bessler to associate ate professor of medicine professor of medicine • Barry P. Sleckman to associ- • Kyunghee Choi to associate ate professor of pathology and Read all abOUt it Catherine Reitz (second from left), coordinator of corporate and foundation professor of pathology and immunology programs and communications, and Jennifer Ochoa (second from right), recruitment assistant in immunology • Dmitriy A. Yablonskiy to human resources, read newspapers to patients at the American Red Cross Aug. 21 as part of the • C. Michael Crowder to asso- professor of radiology (May 2) University's sixth annual Days of Caring. This year, more than 50 University employees turned out ciate professor of anesthesiology to lend a hand to several community organizations, including the National Multiple Sclerosis (May 2) Granting of tenure Society, Lutheran Senior Services and the Jewish Center for the Aged. Volunteers assisted indi- • Daved H. Fremont to associ- • Yossi Aviv as associate profes- viduals with disabilities, helped children in pre-school and served food and played games with the ate professor of pathology and sor of operations and manufactur- elderly, among other activities. immunology ing management • Jonathan Green to associate professor of medicine Appointed with tenure • Melissa Jonson-Reid to • Anjan V. Thakor as professor associate professor of social work of finance Obituary • Rebecca Messbarger to • Thomas Oltmanns as profes- associate professor of Italian in sor of psychology in Arts & Arts & Sciences Sciences. Hilgert, 73; Olin School of Business

BY ROBERT BATTERSON centrality of teaching at the and graduated in 1948 from University," said Stuart I. Green- Southwest High School. He earned For the Record Raymond L. Hilgert, D.B.A., baum, Ph.D., dean of the Olin a bachelor's degree in mathemat- emeritus professor of manage- School. "His uncompromising ics, from Westminster College, and associate professor of biology in ment and industrial relations in concern for students and their master's and doctoral degrees from Of note Arts & Sciences, has received a the Olin School of Business, died learning experience helped shape Washington University. five-year, $878,146 grant from the Saturday, Aug. 23, 2003, at St. the caring culture of the Olin Hilgert served in the Air Force National Science Foundation for Luke's Hospital in Chesterfield, School and Washington University. as an air weather officer from Timothy E. Holy, Ph.D., assis- research titled "Actin Assembly in Mo., after a three-year battle with "He was an institution within 1952-56. tant professor of anatomy and Non-Motile Cells."... cancer. an institution. As a certified labor arbitrator, neurobiology, was one of 20 Brian Wrenn, Ph.D., assistant He was 73 and lived in His clarion call for decades Hilgert helped settle people named a 2003 Pew professor of civil engineering, has Kirkwood, Mo. will be missed." many area labor disputes. Hilgert Scholar in Biomedical Sciences, received a one-year, $102,569 An award-winning teacher, Arthur E. published more than 90 articles in recognizing "America's most grant from the University of author and labor arbitrator and a Carlson, Ph.D., human resources and business promising biomedical Cincinnati for research titled nationally recognized media com- emeritus pro- journals and was the co-author of researchers." The award includes "Surface-Atmosphere Geo- mentator and business ethicist, fessor of six books. $240,000 over four years for chemistry Explorer New Fron- Hilgert taught at the University accounting, Hilgert was active in his church additional research. Holy's neu- tiers Mission Concept Study." ... from 1961-2001. said Hilgert put and this year was awarded the robiology studies seek to detect Philip D. Stahl, Ph.D., Hilgert was as a mainstay in teaching and Christus Vivit Award by Concordia how organisms recognize pat- Edward Mallinckrodt Jr. Pro- the business school's personnel Hil9ert his students Seminary. terns and form memories.... fessor and head of cell biology management and labor relations first. Among survivors are his wife, Michael Sherraden, Ph.D., and physiology, has been named programs while tirelessly champi- "He was a master teacher, and Bernice, three children and eight the Benjamin E. Youngdahl the 2003 Women in Cell Biology oning the importance of business he thought that teaching was grandchildren. Professor of Social Devel- Senior Awardee. The award was ethics. Known for the attention more important than anything A memorial service is planned opment, has received a one-year, conferred by the American and concern he showered on stu- else," Carlson said. "Ray felt that if for 7 p.m. Sept. 5 at St. Paul's $84,969 grant from the Cor- Society for Cell Biology for out- dents, Hilgert was outspoken in a professor spent all his time just Lutheran Church, 12345 poration for Enterprise standing scientific achievements his concern that leading business doing research, you weren't doing Manchester Road in Des Peres, Development for research titled coupled with a long-standing schools not allow faculty research your students justice, but he was Mo. Memorial contributions may "Research Design for SEED record of support for women in to overshadow the importance of also a tremendous researcher. He be sent to the student aid fund at Policy and Development science and by mentoring both classroom education. did the best job of anyone I knew Lutheran High School South; Initiative."... men and women in scientific "Professor Hilgert was an out- balancing the two." 9515 Tesson Ferry Road; St. Louis, Kathryn G. Miller, Ph.D., careers. spoken voice advocating for the Hilgert grew up in St. Louis MO 63123.

fully genetically engineer a food inoculation and its close relative, reached many people and has Scripps Family Chair in Cell crop with a disease-resistance tomato mosaic virus, they were been proven effective for many Biology, and he co-directed the Patent trait. highly resistant to infection. Work different crops. What's truly International Laboratory for - from Page 1 "The creation of disease- conducted since the original dis- exciting is its potential to increase Tropical Agricultural Biotech- resistant plants will bring benefits covery has demonstrated that the food production in developing nology. Fraley said. throughout the world, thanks to "coat protein" in the transgenic countries." Beachy was a member of the In addition to the successes in the pioneering work of Beachy plants restricts infection and Beachy, a member of the University's Department of papaya, Monsanto is collaborat- and our many other outstanding thwarts the ability of the virus to National Academy of Sciences, is Biology from 1978-1991, when ing with the Danforth Center and biology faculty and their scientif- successfully infect the plant. internationally known for his he was professor and Director of the Kenya Agricultural Research ic colleagues at Monsanto," Aphids spread many different groundbreaking research on the Center for Plant Science and Institute to develop a virus-resist- Chancellor Mark S. Wrighton types of plant viruses, and it is virus-resistant plants. Biotechnology. He rejoined the ant sweet potato. said. "This discovery is another common practice to control virus He is the founding president department in 1999 upon his "We are delighted that this example of St. Louis' emerging infection by using chemical insec- of the not-for-profit Danforth appointment to the Danforth technology, as one of the first role as a world leader in plant ticides to limit spread of viruses. Center. In this role, Beachy has Center. applications of biotech, is helping research and the exceptional his- The "coat-protein mediated resist- been responsible for developing Research under Beachy's to advance science throughout tory of collaboration between ance" technology, like other dis- and implementing the Danforth direction has led to a number of the globe," Fraley said. this university and industry." ease resistance genes, can substan- Center's strategic direction, patent applications. He has edit- The technique was conceived, The group of scientists devel- tially reduce farmers' reliance on recruiting its staff, and formulat- ed or contributed to 50 book developed and tested in the oped a gene that, when intro- chemical insecticides. ing its research programs. articles, and his work has pro- 1980s. duced to plant cells, would cause Therefore, this technology has The center, established in duced more than 200 peer- The research began in the the cells to produce the virus helped solve an otherwise unsolv- 1998, is affiliated with many reviewed publications. early '80s with attempts to make "coat," a protein normally made able problem in agriculture. businesses and universities and Fraley oversees Monsanto's tobacco plants resistant to a virus by the virus to ensheath the With the granting of this focuses on interdisciplinary crop and seed agribusiness tech- called tobacco mosaic virus. This virus's genetic information. patent, Monsanto can continue to research in genetics, chemistry, nologies and research platforms involved constructing target genes Tomato plants that were pro- license the patent to interested cell biology, biochemistry, com- with facilities in almost every containing a viral-coating protein duced from the modified cells — parties. putational genomics and struc- world area. He has authored and inserting them into tobacco transgenic plants — produced "It is gratifying to see the tech- tural biology. more than 100 publications and leaf tissue. Plants regenerated the coat protein in very small nology we developed nearly two From 1991-98, Beachy headed patent applications relating to ' from this tissue were able to resist amounts in comparison to the decades ago reach this stage and the Division of Plant Biology at technical advances in agricultur- the virus. amount of coat protein that is have the impact that it has had The Scripps Research Institute, a al biotechnology. In 1987, the researchers tried produced during virus infection. and will have on agriculture leading biomedical research cen- Fraley received the National the technique with tomatoes and While these plants were "chal- throughout the world," Beachy ter in La Jolla, Calif. There he Medal of Technology from became the first team to success- . lenged" by tobacco mosaic virus said. "The technology already has also was professor and held the President Clinton in 1999. 8 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS Aug. 29,2003 Washington People

Washington University is known for many things — among them its high academic standing, its research, its collegiate Gothic architecture. But what many people may not realize is that the University is home to the largest single collec- tion of German contemporary lit- erature in the United States. It also has one of the best graduate de- partments in German literature and culture in the country, thanks in large measure to the efforts and commitment of Paul Michael Liitzeler. Lutzeler, Ph.D., the Rosa May Distinguished University Profes- sor in the Humanities and profes- sor of German and comparative literature in Arts & Sciences, was born in a small German Rhine- land town. He came to the United States in 1968. After earning a doctorate in German literature at Indiana University in 1972, he moved to St. Louis and is now beginning his 30th year at Washington University. He founded the European Paul Michael Lutzeler, Ph.D. (right), the Rosa May Distinguished University Professor in the Humanities Studies Program in Arts & and professor of German and comparative literature in Arts & Sciences, discusses a German novel Sciences, and he directed the pro- with Kamaal Haque, a German and comparative literature major.

European universities," he says. on any and all projects that stu- After an exchange year at dents present to him and most 'A man of phenomenal energy* Indiana University, Lutzeler decid- importantly, encourages further ed he wanted to become a profes- exploration in the field." gram for more than 20 years with tain the collection." sor at an American university. Lutzeler has helped to build Paul Michael the help of administrative assistant The Suhrkamp Publishing Co., "I got to know the American several cultural exchange pro- Ellen Feinstein. More than 80 stu- the most prestigious publisher in higher-education system and real- grams between the University and Lutzeler has grown dents have graduated with a mas- Germany, has granted the center ized I liked it much better than schools in Germany, including the ter's degree from the program the "Suhrkamp/'Insel Collection." the German system," he says. University's formal relationship the contemporary since its inception. It contains all publications of the Lutzeler has four main areas of with Tubingen University, and he Lutzeler has organized or co- company since 1980 — a sort of research interest: German and established the Suhrkamp Fellow- German literature organized five international sym- "treasure within a treasure," European romanticism; exile liter- ship and the Piper Fellowship for posiums and invited many visiting according to Lutzeler. ature; European identity; and of graduate students in the German collection and has professors to the Hilltop Campus, The center is part of the De- course, contemporary German lit- department. supported by the Fulbright Foun- partment of Germanic Languages erature. When he isn't teaching and dation, the German Academic and Literatures in Arts 8c Sciences Lutzeler has studied extensive- traveling, Lutzeler enjoys ice skat- enhanced the Exchange Service and the Swiss in Ridgley Hall. In addition to its ly the life and works of Hermann ing, jogging and mountain hiking. foundation Pro Helvetia. literary holdings, the center spon- Broch, a Jewish/Austrian author He reads a lot, especially history graduate program Last year, Lutzeler started a new sors a visitor's program. who left Austria in 1938 and fled books, and has a passion for art. scholarly yearbook on contempo- Every year since 1985, the cen- to the United States, where he "Whenever I go somewhere, I rary German literature. ter has invited one prominent lived and wrote until his death in always make sure to see the local But the accomplishment for writer and one leading critic from 1951. Lutzeler wrote Broch's biog- art museum," he says. which he is most noted is the a German-speaking country to raphy, edited his collected works Lutzeler visits Germany quite founding of the Max Kade Center teach a graduate course on con- in 17 volumes and wrote several often, especially in the summer. for Contemporary German Liter- temporary German literature. The essays on him. For the Broch "It's simply too hot in St. Louis in ature in 1980. visitors are supported by a grant biography he received the DAAD the summer," he quipped. "Together with Egon Schwarz, I from the Max Kade Foundation. prize of the German Studies Though Lutzeler has had of- had organized a symposium on Furthermore, the center organ- Association. fers to move to other places, he contemporary German literature at izes weekend seminars for doctor- Lutzeler has also examined has never accepted them. the University," Lutzeler says. "I al students and young faculty and documented how European "I've always preferred Wash- found out that our holdings in members from all over the coun- identity developed, concentrating ington University," he says. "I def- BY NEIL SCHOENHERR contemporary German literature try. Financial support for these especially on the contributions of initely think the University is on were not very good. Things needed seminars came from the Thyssen writers and novelists. He has pub- the right track. to be improved, but there was no Foundation in the past and now lished nine books and numerous "There has been an enormous additional money available." comes from the Volkswagen editions, several of which deal improvement in resources and Lutzeler began writing to Foundation. with the interrelation between lit- facilities on campus since I came German publishers, telling them The center is also able to give erature and history, and with con- here. I have also been granted a he wanted to establish a collection summer grants to doctoral candi- temporary scholarly discourse in great deal of freedom to develop of contemporary German litera- dates and faculty members from the humanities. Some of his programs and start the (Max ture and asking them to send other American universities books have been translated into Kade) center. copies of their recent production. thanks to support from the English, Spanish, Italian and "When you come up with Most of the publishers agreed with Suhrkamp Foundation, the Max Japanese. good ideas, the University is very the concept. Kade Foundation and the German His tireless work in his fields open to hearing them." "We now have 150 publishers Academic. Exchange Service. of study has not gone unnoticed. from German-speaking countries "Mike (as Lutzeler is known by For his work on Hermann Broch, that contribute to the collection," friends and colleagues) is a man of he received the Austrian Medal of he said. phenomenal energy who belongs Honor in Arts and Sciences, First He administers the collection to the leading scholars of German Class and in May 2002, he was "His vision has played a with the help of Hanne Spence, his literature and culture of his gener- awarded the German Cross of vital role the shaping of administrative assistant, and with ation," says Lynne Tatlock, Ph.D., Merit, First Class. support from Olin Library and the professor and chair of Germanic' Lutzeler is an honorary mem- our present-day German Max Kade Foundation in New York. languages and literatures. "His ber of the American Association of department and "Without the cooperation of vision has played a vital role the Teachers of German, an organiza- Olin Library," Lutzeler says, "we shaping of our present-day Ger- tion that gave him the Outstand- particularly in establish- would not have been able to main- man department and particularly ing Educator Award, and is a ing, enhancing and in establishing, enhancing and member of two German Aca- maintaining our German graduate demies of Arts and Sciences. He maintaining our German program. has won a Distinguished Faculty graduate program." "He has never been one to be Mentor Award from the University. content to rest on his laurels and Among the many grants he has LYNNE TATLOCK is not only continually setting out received are fellowships from the in new directions in his teaching Guggenheim Foundation and the and scholarship, but is also unfail- American Council of Learned Paul Michael Liitzeler ingly willing to pitch in the day- Societies. He has been a visiting to-day tasks of keeping a complex professor at leading schools in Years at the University: 30 department running well." Europe, Australia and the United States. Hobbies: Ice skating, jogging, moun- Research interests "I have a great deal of respect tain hiking, reading history and visit- Liitzeler's interest in compara- for Professor Liitzeler's continued ing art museums tive literature began at a young age interest in the progress of scholar- Notable: Founder and former director while he was still a student in ship in the field of German," said of the European Studies Program in Germany. Sarah McGaughley, a graduate Arts & Sciences; founder and current Liitzeler and his wife, Ingrid, relax at home with their daughter, "I developed a very early love student in the department who is director of the Max Kade Center for Andrea (second from left; with her friend, Josh), and son, Thilo for literature and studied German, currently working on her disserta- Contemporary German Literature (third from left; with his friend, Saaba). English and history at several tion. "He offers critical feedback