Ligands from VSMC to Receptors from ABC

Younger App

Ctsl H2−Eb1

Ctsf

Mif Cd74 Differential Expression Differential

Ogn Older

VSMC ABC Ligands from ARP to Receptors from ABC

Younger Ctsl

H2−Eb1 Ctsf

App Cd74 Differential Differential Mif Older

ARP ABC Ligands from ARP to Receptors from ASC Younger

App

Cd9

Izumo4

Differential Gene Expression Differential Ntm

Hbegf Older

ARP ASC Ligands from ASC to Receptors from ARP

Slc1a5 Pparg Fzd2 Egfr Plxnb2

Younger Avp Adcyap1r1 Fgfr1 Lrp8 Fzd7 Erbb2 Clu Folr1 Tfrc Fzd3 Gabbr1 Bsg Cst3 Fzd9 Lrp1 App Smo Grm3 C1qa Rara Itgb5 P4hb Itgb1

Differential Gene Expression Differential Itgav Efemp1 Nlgn3 Vldlr Ldlr Cd44 Tgfbr1 Fzd10 Fjx1 Scarb1 M6pr Fzd4 Older Fzd1 Fzd8

ASC ARP Ligands from ARP to Receptors from EC Younger

Izumo4

Cd9

Hbegf Differential Gene Expression Differential Older

ARP EC Ligands from EC to Receptors from ARP Ldlr Pparg Tfrc Lrp8

Younger Plxnb2 Cst3 Tgfbr1 Ackr3 Gabbr1 Cxcr4 Fgfr1 Lrp1 Apoe Scarb1 Slc1a5 Fgfr3 Adcyap1r1 App Tyro3 Clu Cd44 Itgb1 Egfr Bsg Differential Gene Expression Differential Itgav P4hb Cxcl12 Folr1 Vldlr Rara M6pr

Older Erbb2 Itgb5

EC ARP Ligands from ARP to Receptors from GABA Younger

App

Plat Lrp1b

Rspo1 Differential Gene Expression Differential Older

ARP GABA Ligands from GABA to Receptors from ARP

Fzd8 Smo

Younger Cd47 Avp Slc1a5 Fzd7 Fzd1 Grm3 Gabbr1 Cst3 Bsg Fzd10 Fzd9 Fzd3 Nptn Differential Gene Expression Differential Fzd4 Slc7a1 Itgb5

Older Fzd2

GABA ARP Ligands from ARP to Receptors from MG Younger

Csf1

Csf1r

Izumo4

P2ry12

Hbegf Differential Gene Expression Differential

Cd9

Cmtm6 Older

ARP MG Ligands from MG to Receptors from ARP

App Fzd4 Hfe Fzd8 Cmtm6 Scarb1 Adcyap1r1 Younger Cxcr4 Tfrc P2ry12 Clu Fgfr1 Fzd10 Cd1d1 M6pr Avp Fcgrt Itgb1 Trem2 Fzd9 Pdgfrl Grn Plxna1 Ryk P4hb Lpar1 Fzd3 C1qc Fgfr2 Tnfrsf1a Fzd7 Itgav Fgfr3 Tnfsf13b Lrp1

Differential Gene Expression Differential Grm3 Tgfbr1 Smo Egfr Ctsl Plxnb2 Vldlr Bsg Pparg Tyrobp Cd44 Fzd2 Mr1 Itga7 Rara B2m Sort1

Older Folr1 Fzd1 Erbb2 Lrp8

MG ARP Ligands from ARP to Receptors from mNEUR Younger

App

Rspo1 Lrp1b

Plat Differential Gene Expression Differential Older

ARP mNEUR Ligands from mNEUR to Receptors from ARP

Itgb5 Grm3

Younger Fzd3 Cst3 Fzd2 Gabbr1 Fzd9 Fzd7 Cd47 Nptn Smo Fzd8 Slc7a1 Fzd4 Avp Differential Gene Expression Differential Fzd1 Slc1a5 Fzd10

Older Bsg

mNEUR ARP Ligands from ARP to Receptors from OLG

Tnr

Apoc1

Trf

Tgfb2 Adipor1

Ttr

Fgf1 Younger Aplp1

Cdh2 Mag

Olfm1

Thbs4

Sulf1

Tnc Itgad

Fgf13

Apoc3

Fgf2 Cntn1 Cyr61

Vegfa

Rspo1

Agt Ddr1 Sdf4

Ide

Nenf

Pdyn Glrb A2m

Nampt

Cmtm3

Tgfb3 Enpp2 Anxa5

Hmgb2

Il18

Differential Gene Expression Differential Aimp1 Kdr Hdgf

Mfge8

Ctf1

Clu Lrp1b Vegfb

Pgf

Vcam1

Il15 Cdh2 Pla2g3

Adam9

Pomc

Cxcl14 Il11ra1 Plat

Glod4

Gsn

Fam213a Itgb5 App

Stoml2

Older Apoe

Txlna App Cst3

Lfng

Ndp

ARP OLG Ligands from OLG to Receptors from ARP

Itga7 Cd44 Egfr Gsn Slc7a1 Adcyap1r1 Cxcr4 Ctf1 Vac14 Itih3 Olfm1 Cd1d1 Gria2 Younger Smo Aplp1 Kcnj10 Tfrc Tgfbr1 Esrra Avp Zfyve27 Nfasc Grik2 Vldlr Plat Slc1a5 Folr1 Grm3 Ddr2 Notch1 Cmtm5 Fzd1 Gabbr1 Itgb5 Rara Clu Fzd2 Fzd9 Fcgrt Fzd10 Trf Tyro3 Bmpr1b Adgrl1 Glrb Cst3 Colec12 Bsg P2rx6 Ldlr Evi2a Jam3 Gabra4 Fgfr3 Nlgn3 Ntrk3 Cntn1 Lrp6 Igf1r Ptprg M6pr Cd151 Fgf13 Hfe Ptpra Lrp5 Differential Gene Expression Differential C1qa Erbb2 Ryk Tcn2 Ddr1 Mr1 Cdh2 Erbb4 Ptprz1 Fzd3 S1pr1 Ptgds Itgb1 Pparg Fzd4 Tlr3 Efemp1 Lrp8 Itgav Lrp1b Fzd7 Rnase4 Sorl1 Notch2 Agrn Amot Chid1 Cdh8 Tnfrsf21 Adipor1 Tspan5 Mag B2m Fzd8 Cdh2 Ntm Scarb1 Edil3 Fgfr1 Fgfr2 Itgb4 App

Older P4hb App Plxnb2 Tm2d1 Tpra1 Itga6 Apoe Ebp Tnfrsf1a Cacnb1 Lrp1

OLG ARP Ligands from PC to Receptors from ARP Tyro3 P4hb App Tgfbr1 Younger Tfrc Lrp8 Clu Bsg Lrp1 Erbb2 Pparg Itgb1 Itgb5 Slc1a5 Cst3 Ldlr M6pr Egfr Itgav Rara Plxnb2 Gabbr1 Differential Gene Expression Differential Apoe Adcyap1r1 Scarb1 Fgfr1 Cd44 Vldlr Older Folr1

PC ARP Ligands from ASC to Receptors from ABC

Pdgfra Fzd3 M6pr Avp Tgfbr1 Erbb2 Nlgn3 Younger Fzd4 Clu Cd44 Bsg App P4hb Cst3 Adcyap1r1 Ldlr Agtr1b Igf2r App Fzd5 Lepr Tgfbr2 Itgb1 Mif Lrp1 Tfrc Cacna1a Fzd9 Cd28 Plxnb2 Itgav Fzd7 Ctsl Adra1b Fzd6 Smo Differential Gene Expression Differential Vldlr Ctsf Fzd2 Slc1a5 Fzd1 Scarb1 C1qa Egfr Rara Gabbr1 Cd93 Efemp1 Itgb5 Ppara Fgfr1 Cp Fjx1 Itga5 Older Itga3 H2−Eb1 Cd74

ASC ABC Ligands from ABC to Receptors from ASC Younger

Izumo4

Cd9

Hbegf

Ntm

Tslp Differential Gene Expression Differential

Crlf2

App Older

ABC ASC Ligands from ASC to Receptors from CPC

App Itgb1 Folr1

Younger Fzd4 Avp Fzd7 Bsg P4hb Plxnb2 Itgb5 Clu Itgav Smo Vldlr Fzd6 Cst3 Lepr M6pr Tgfbr2 Igf2r Gabbr1 Differential Gene Expression Differential C1qa Pdgfra Lrp1 Fgfr1 Itga3 Older Lrp8

ASC CPC Ligands from CPC to Receptors from ASC Younger

App Ntm Differential Gene Expression Differential Older

CPC ASC Ligands from ASC to Receptors from DC

Plxnb2 Itgb1 Tgfbr1 Younger Clu M6pr Bsg Tgfbr2 Ldlr Cst3 Itga4 Itgb2 Fgfr1 App C1qa Cd44 P4hb Slc1a5 Differential Gene Expression Differential Efemp1 Scarb1 Lrp1 Rara

Older L1cam

ASC DC Ligands from DC to Receptors from ASC Younger

App Ntm Differential Gene Expression Differential Older

DC ASC Ligands from ASC to Receptors from DOPA L1cam Lrp8 Grm1 Grm2

Younger Avp Grm5 Itgav Adcyap1r1 App Tfrc Clu Itgb1 Ryr2 Pparg Egfr Grm4 Cst3 Igf2r Plxnb2 Fgfr1 Cacna1a M6pr C1qa Scarb1 Nlgn3 Differential Gene Expression Differential Bsg Lrp1 Grm7 Efemp1 Gabbr1 P4hb Fzd9

Older Rara Adra1b

ASC DOPA Ligands from DOPA to Receptors from ASC Younger App Cd9

Izumo4

Rorb

Hbegf Differential Gene Expression Differential Ntm Nppa Older

DOPA ASC Ligands from ASC to Receptors from EC

Tfrc M6pr Avp Gabbr1 Ryk Grm3 Clu Fzd6

Younger Fzd9 Lrp8 Cst3 Tgfbr2 Vldlr Lepr Psap Adcyap1r1 App Scarb1 Apoe Itga3 Itgav Egfr Hmgb1 Lrp1 Nlgn3 Ppara C1qbp Plxnb2 Fzd2 Fzd4 Stoml2 Adra1b Itga4 Fzd1 Esr1 S100a8 Fzd5 Tgfbr1 Fgfr1 Hbegf Grm5 Fzd8 Cacna1a Differential Gene Expression Differential B2m Igf2r Erbb2 P4hb Hmgb2 Cd44 Ldlr Itga5 Izumo4 Itgb1 Cd93 Smo Trf Slc1a5 Grm7 Fzd3 C1qa Itgb5 Itgb2 Pdgfra Efemp1 Rara Plaur Older L1cam Fjx1 Bsg Cp Cd9

ASC EC Ligands from EC to Receptors from ASC

Cd9 Ednrb Bsg Tfrc Cst3 Cd44

Younger Fgfr3 Tyro3 Erbb2 Apoe Ackr3 Ldlr Lrp12 Plxnb2 Adcyap1r1 Clu Itgav Tgfbr1 Fgfr1 Dcc Egfr Hbegf Pdgfra Lrp1 Pgr App App Scarb1 Itgb1 Cxcr4 Adra1b Itga5 Tslp

Differential Gene Expression Differential Ryr2 Itga3 Pparg L1cam Izumo4 Gabbr1 Tgfbr2 Igf2r Itgb5 Itga4 Edn1 Lrp8 Rara Cp M6pr Vldlr Cxcl12 P4hb Older Slc1a5 Ntm Crlf2

EC ASC Ligands from ASC to Receptors from EPC

Smo Itgav Bsg Erbb2 Gabbr1

Younger Avp Fzd2 Cd36 Fzd3 Folr1 Igf2r Clu Itgb5 Plxnb2 Lrp2 Cd44 Vldlr Cst3 Lrp8 Fzd10 App Cacna1a M6pr C1qa Fzd6 Lrp1 Itga3 Ldlr

Differential Gene Expression Differential Fgfr1 Efemp1 Itgb1 Tgfbr1 Cp P4hb Tgfbr2 Scarb1 Fjx1 Adcyap1r1 Nlgn3 Fzd8 Older Rara Ryr2

ASC EPC Ligands from EPC to Receptors from ASC Younger

App Cd9

Izumo4

Tfrc

Hbegf Differential Gene Expression Differential

Ntm B2m Older

EPC ASC Ligands from ASC to Receptors from GABA

Grm5 Nlgn3 Tfrc App Avp Gabbr1 Grm4

Younger Itgb1 Itgav Vldlr Clu Itga5 Grm2 Fzd1 Lrp1 L1cam Cst3 Cp Drd1 Esr1 Ryr2 Fzd2 Psap Erbb2 Lrp8 Fzd5 Fzd9 Plxnb2 Plat P4hb Scarb1 Fzd4 Pdgfra Sfrp4 Oxtr Igf2r Itga3 Egfr

Differential Gene Expression Differential Ldlr App Tgfbr1 Rara Adra1b Fgfr1 Grm1 C1qa Adcyap1r1 Bsg Grm8 M6pr Fzd7 Efemp1 Grm3 Itga4 Grm7 Tgfbr2 Itgb5 Fjx1 Pparg Older Cacna1a Fzd3 Fzd6 Lrp1b

ASC GABA Ligands from GABA to Receptors from ASC

Cd9 Bsg Tfrc Avp

Younger Fzd8 Fzd6 Grm5 Cst3 Fzd2 Fzd3 Fzd4 Slc7a1 Nptn Ryr2 Grm7 Grm2 Apoe Fzd10 Fzd9 Adra1b

App Fzd5 Gabbr1

Differential Gene Expression Differential Smo Itgb5 Izumo4 Grm8 Ptprj Fzd7

Hbegf Fzd1 Grm3 Grm4 Slc1a5 Nppa Cd47 Older Rorb Ntm

GABA ASC Ligands from ASC to Receptors from GLUT

Adra1b Tfrc L1cam Esr1 Grm5 Itgav Avp Younger App Adcyap1r1 Cd44 Gabbr1 Ryr2 Nlgn3 Clu Scarb1 Fzd7 Grm7 Lrp8 Itgb5 Pparg Plxnb2 Cst3 Grm2 Rara Itgb1 Grm8 Fzd8 Vldlr Psap Fzd1 Igf2r Grm1 Drd1 Smo Itga5

Differential Gene Expression Differential Slc1a5 C1qa Ldlr Fzd5 Tgfbr1 Grm3 Lrp1 Cacna1a Efemp1 Cd93 Fzd3 Fgfr1 Oxtr Itga3 Grm4 P4hb Fjx1 Tgfbr2 Bsg

Older Itga4 Fzd9 Pdgfra M6pr

ASC GLUT Ligands from GLUT to Receptors from ASC Younger

App

Cd9

Nppa

Rorb

Izumo4 Differential Gene Expression Differential

Ntm

Hbegf Older

GLUT ASC Ligands from ASC to Receptors from Hb_VC

Tgfbr2 Itgav Grm3

Younger Avp Fzd6 Lrp8 Gabbr1 Clu Bsg Itgb1 Smo Cd93 Cst3 Scarb1 Lrp1 M6pr C1qa Cp P4hb

Differential Gene Expression Differential Tfrc App Efemp1 Itgb5 Fzd4

Older Cacna1a

ASC Hb_VC Ligands from Hb_VC to Receptors from ASC Younger

App Cd9

Hbegf Ntm Differential Gene Expression Differential Older

Hb_VC ASC Ligands from ASC to Receptors from ImmN

P4hb App

Younger L1cam Avp Vldlr Gabbr1 Lrp8 Clu Itgb1 Bsg Tgfbr1 Cst3 Adcyap1r1 Nlgn3 Fzd2

Differential Gene Expression Differential Plxnb2 C1qa M6pr Lrp1

Older Fzd3

ASC ImmN Ligands from ImmN to Receptors from ASC Younger

App Cd9

Izumo4 Ntm Differential Gene Expression Differential Older

ImmN ASC Ligands from ASC to Receptors from MAC Tgfbr2 Itgb2 Rara Tfrc

Younger Avp Tgfbr1 Itga4 Slc1a5 Adcyap1r1 P4hb Clu Smo Fgfr1 Bsg Pparg Egfr Cst3 App Cd36 Lrp1 Cp Gabbr1 C1qa Scarb1 Itgav Differential Gene Expression Differential Ldlr Plxnb2 Cd93 Efemp1 Itgb1 Fzd7 M6pr

Older Itgb5 Cd44

ASC MAC Ligands from MAC to Receptors from ASC

Younger Izumo4

Cd9

Hbegf

App Ntm

Il16 Differential Gene Expression Differential Crlf2

Tslp Older

MAC ASC Ligands from ASC to Receptors from MG

Csf1r P2ry12 Tgfbr1 Avp Itgb5 Scarb1 Gabbr1

Younger Itgb1 Clu Tgfbr2 App P4hb Cst3 Tfrc Itgav Rara Bsg Psap Cd44 Fgfr1 Grm3 Plxnb2 Mdk Fzd4 Cd93 Cd36 Fgf1 Grm5 Adcyap1r1 Itga4 Grm1 Cmtm6 Esr1 Egfr Lrp8 Fzd2 Il34 L1cam Nlgn3

Differential Gene Expression Differential Slc1a5 Csf1 Ryr2 Pdgfra Igf2r Fzd7 Hbegf Grm2 Fzd9 Itga5 Treml2 Izumo4 Fzd5 Fzd8 Vldlr C1qa Cp Cacna1a Itgb2 Smo Efemp1 Ldlr M6pr Plaur Older Lrp1 Fjx1 Notch2 Trem2 Cd9

ASC MG Ligands from MG to Receptors from ASC

Cd9 Bsg Tfrc Cmtm6 Itga7 Cd44 Fgfr3 Fzd8 Cacna1a Clu Younger Tyro3 Erbb2 Fcgrt Plxna1 Avp Fzd6 Grm5 Plxnb2 Adcyap1r1 Fzd2 Grn Itgav Tgfbr1 Fzd3 Fgfr1 C1qc Egfr Pdgfra Fzd4 Adra1b Itga5 Apoe Itga3 Fzd9 Itgb1 Hfe App Cxcr4 Tnfrsf13b Grm2 Ryk Hbegf Lrp1 Fzd5 App Fzd10 Scarb1 Il16 Grm7 Pparg Tgfbr2 Pdgfrl Differential Gene Expression Differential Izumo4 L1cam Grm8 Smo Lpar1 Mr1 Tslp Sort1 Nckap1l Erbb3 Igf2r Anxa5 Fgfr2 Lrp8 Rara Fas Tnfsf13b Cp Cd1d1 H2−Eb1 Ppara M6pr Ctsl Fzd7 Vldlr Fzd1 Grm3 Tyrobp P4hb Grm4 Slc1a5 Older P2ry12 Tnfrsf1a B2m Cd74 Trem2 Ntm Crlf2

MG ASC Ligands from ASC to Receptors from MNC

Slc1a5 Lrp1 Ldlr Younger Clu Itga4 App Plxnb2 Itgb2 Cst3 M6pr Tgfbr1 Itgb5 Rara C1qa Scarb1 Cd44 Itgb1 Differential Gene Expression Differential Efemp1 P4hb Bsg Cd36

Older Tgfbr2

ASC MNC Ligands from MNC to Receptors from ASC Younger

App Cd9

Il16 Ntm Differential Gene Expression Differential Older

MNC ASC Ligands from ASC to Receptors from mNEUR

Tfrc Grm5 App Grm2 Avp Nlgn3 Gabbr1 L1cam

Younger Grm4 Itgav Vldlr Clu Adra1b Itgb1 Esr1 Ryr2 Lrp8 Cst3 Cd44 Lrp1 Folr1 Plxnb2 Itga5 Psap Fzd8 Drd1 Fzd2 Fzd1 Grm8 Plat Fzd4 Cp Itgb2 Erbb2 Igf2r Oxtr App Scarb1 Lepr Rara Itga3 Smo Sfrp4 Ldlr Differential Gene Expression Differential Fzd7 Adcyap1r1 Grm1 Fzd5 Trf Grm3 Egfr Itgb5 Slc1a5 Cd93 C1qa Pdgfra Grm7 Bsg Cacna1a Tgfbr1 Fzd9 Efemp1 Pparg Fgfr1 P4hb Tgfbr2 Itga4 Older Fjx1 Fzd6 M6pr Fzd3 Cd36 Lrp1b

ASC mNEUR Ligands from mNEUR to Receptors from ASC

Cd9

Bsg

Cst3 Tfrc Fzd8 Younger Tyro3

Nptn Fzd6 Grm5

Fzd2

Fzd3 Avp Fzd4

Adra1b

Fzd9 Apoe Slc7a1

Grm2

Ryr2 Psap Fzd10

Fzd5

Grm7 App Gabbr1

Grm8 Differential Gene Expression Differential Smo Tslp Ptprj

Itgb5

Fzd7 Izumo4 Vldlr

Fzd1

Grm3

Hbegf Grm4

Slc1a5

Cd47

Nppa Rorb Older

Ntm

Crlf2

mNEUR ASC Ligands from ASC to Receptors from NRP

Plxnb2 Tfrc P4hb

Younger Avp Gabbr1 Fgfr1 Itgb1 Clu Lrp8 Scarb1 Tgfbr1 Cst3 Lrp1 App Egfr C1qa Fzd1 Cacna1a Fzd2 Differential Gene Expression Differential M6pr Efemp1 Adcyap1r1 Slc1a5

Older Bsg

ASC NRP Ligands from NRP to Receptors from ASC Younger

App Ntm Differential Gene Expression Differential Older

NRP ASC Ligands from ASC to Receptors from NSC Lrp8 Bsg Tgfbr1 Adcyap1r1 Younger Avp Fzd2 Scarb1 Gabbr1 Clu Tfrc Fzd6 App Fzd5 M6pr Cst3 Egfr Itgav Grm3 Cacna1a C1qa Nlgn3 Smo

Differential Gene Expression Differential Lrp1 Itgb5 Efemp1 Itgb1 P4hb Plxnb2 Older Fgfr1

ASC NSC Ligands from NSC to Receptors from ASC Younger

Hbegf

Cd9

Izumo4

Ntm

App Differential Gene Expression Differential Older

NSC ASC Ligands from ASC to Receptors from OEG

Tgfbr1 Tfrc Lrp1 App Nlgn3

Younger Avp Igf2r Fzd7 Rara Itgb1 Lrp8 Clu Fzd3 M6pr Fzd6 Fzd1 Fzd5 Cst3 Tgfbr2 Bsg Erbb2 Slc1a5 Fgfr1 C1qa Scarb1 Plxnb2 Itgav Gabbr1

Differential Gene Expression Differential Ldlr Efemp1 L1cam Ppara Grm3 Vldlr Adcyap1r1 Cd44 Fjx1 Smo Fzd2 Grm5 Older P4hb Cp

ASC OEG Ligands from OEG to Receptors from ASC Younger App Cd9

Izumo4

Tfrc

Il16

Fgfr3

Differential Gene Expression Differential Hbegf

Ntm B2m Older

OEG ASC Ligands from ASC to Receptors from OLG

Avp Adipor1 Clu Mag Cst3

Psap Itgad

Fgf1 Cntn1 Aplp1 Ddr1 Efnb2

Pomc Glrb

Nenf Enpp2

Younger Fgf13 Ephb6 Apoe

Ttr Tfrc

Cxcl16 Gabbr1 Vegfb Nlgn3 Thbs4

S100a9 Fzd3

Bdnf Ldlr Plat Fzd8 Cyr61

Ndp Adcyap1r1

Fgf7 Adra1b Cdh2 Drd1 Stoml2 M6pr Apoa2

Vegfa Smo Pla2g5 Fzd4 Olfm1 Igf2r Il18

S100a8 Itgb1 Vcam1 Lrp8 Pgf Itga3 Pdyn

Fgf12 Grm4

Tgfb3 Egfr Chgb Fzd5 Lpl

Fgf9 Fzd6

Il15 P4hb Pla2g3 Slc1a5 Sdf4

Tnfsf10 Grm2

Sfrp4 Ppara Hdgf Plxnb2 A2m

App Cd93

Vegfc Fzd9 Adam9 Ryr2 Anxa5

Differential Gene Expression Differential Fgf2 Grm1

Wnt4 Pdgfra Tgfb2 L1cam Tnfsf13b

L1cam Grm5

Apoc1 Grm8 Spp1 Cd44 Fgf10 Fzd1 Sulf1

Tnc Fzd2 Cdh5 Itga4 Tnr Lrp1 Fam213a

Angpt2 Esr1

Dmkn Rara Fgf18 Itgb2 Ly86

Ctf1 Tgfbr1

Cxcl14 Bsg Il2 Cp Cd28

Apoc3 Scarb1

Tgfb1 Tgfbr2 Nampt Fzd7 Olfm3

Edil3 Fgfr1

Aimp1 Cacna1a Ide Vldlr Angptl4

Mfge8 Itgav

Txlna Grm7 Glod4 Grm3 Apoa1

Agt Alcam Older Lfng Kdr Cmtm3 Lrp1b Hmgb2 Cdh2 Gsn

Trf Il11ra1 C1qa Itgb5 Efemp1 App Fjx1

ASC OLG Ligands from OLG to Receptors from ASC

Cd9 Kcnj10 Epha4 Bsg Gsn Tfrc Itga7 Notch1 Cd44 Fgfr3 Itih3 Fgf13 Adipor1 S1pr1 Ntrk3 Aplp1 Tnfrsf21 Tm2d1 Tlr3 Fzd8 Younger Cacna1a Avp Tyro3 Cacng3 Erbb2 Ddr2 Fcgrt Plat Glrb Agrn Fzd6 Nlgn3 Lpar3 Lgi3 Cdh2 P2rx6 Ldlr Grm5 Lrp12 Cmtm5 Plxnb2 Ptprr Cacnb1 Adcyap1r1 Clu Fzd2 Itgav Cd93 Tgfbr1 Sorl1 Trf Cd46 Fzd3 Fgfr1 Dcc Olfm1 Pdgfc Egfr Grin1 Pdgfra Cntn4 Fzd4 Cst3 Fzd10 Lrp1 App Ebp Tpra1 Jam3 Grm2 Adra1b Ryk Itga3 Cntn1 Esrrg Scarb1 Hfe Itga5 Ddr1 Efna1 Ryr2 Cxcr4 Cacng2 Sstr2 Ptprc Hbegf Fzd9 Gpr12 Slc7a1 Mag Itgb1 Nppa Grik2 Tspan5 Grm7 Fzd5 Izumo4 Amot Il1rap Itgb4 Itga4 Differential Gene Expression Differential Colec12 Cd151 Cntnap1 Tgfbr2 Itgb2 L1cam Tcn2 Manf Erbb3 Itgb5 Smo Ptprj Ptprb C1qa Nckap1l Pparg Ptger1 Evi2a Mr1 Cdh2 Igf2r Ptprk Ptprg Grm8 Ptgds Vipr2 Gabbr1 Tlr4 Esrra Igf1r Creg1 Fgfr2 Ctf1 Erbb4 Lrp8 Rara Efemp1 Bmpr1b Ptpro Ager P2ry2 Itgam Rnase4 Adgrl1 Ephb4 Fas Chid1 Cp Cdh8 Olfm3 Ar Lrp6 Cntn2 B2m Cd1d1 Rarb Itga6 Vac14 Ppara Sostdc1 M6pr Fzd7 Vldlr Zfyve27 Fzd1 Edil3 Grm3 Lrp5 P4hb Grm4

Older Slc1a5 App Ptpra Tlr2 Ptprz1 Slc40a1 Il33 Notch2 Nfasc Ngfr Gabra4 Gria2 Apoe Tnfrsf1a Lrp1b Cd74 Rorb Ntm

OLG ASC Ligands from ASC to Receptors from OPC

Smo Bsg Gabbr1 Slc1a5 Scarb1 Avp Nlgn3 Younger Fzd8 Fzd9 Itga4 Ppara Fzd4 Clu Vldlr Grm7 Rara Tfrc Fzd6 Ldlr Cst3 Grm3 Tgfbr2 Fzd7 P4hb Lrp8 Fzd1 Psap Grm4 Cacna1a Adra1b Ryr2 Plxnb2 Mdk Itga3 Differential Gene Expression Differential Fzd3 M6pr Tgfbr1 Igf2r Fzd2 C1qa L1cam Fgfr1 Itgb1 Lrp1 Itgb5 Itgav Efemp1 Grm5 Pdgfra Adcyap1r1 Older Cp App Ptprz1

ASC OPC Ligands from OPC to Receptors from ASC Younger

Izumo4

Cd9

Hbegf Differential Gene Expression Differential

Ntm

App Older

OPC ASC Ligands from ASC to Receptors from PC

Tfrc Fzd6 Gabbr1 Tgfbr1 Erbb2 Avp

Younger Grm5 P4hb Vldlr Itga4 Lepr Clu Ldlr Fzd2 Itga5 Fzd8 Nlgn3 Adcyap1r1 Cst3 Egfr Fzd1 Rara Itgav M6pr Psap Tgfbr2 Smo Fgfr1 Plxnb2 Slc1a5 Lrp1 C1qa Cd93 Differential Gene Expression Differential Grm3 Fzd10 Fzd3 Grm7 Efemp1 Scarb1 Lrp8 Cacna1a Igf2r Itgb1 Fzd4 Fjx1 Itga3 App Older Itgb5 Cp Bsg

ASC PC Ligands from PC to Receptors from ASC

Cd9 Bsg Tfrc Cd44 Clu Tyro3 Younger Erbb2 Ldlr Lrp12 Plxnb2 Cst3 Adcyap1r1 Itgav Tgfbr1 Fgfr1 Dcc Apoe Egfr Pdgfra Ryr2 App Lrp1 Scarb1 Izumo4 Itgb1 Itga5 Itga3 Adra1b Tgfbr2 Tslp Gabbr1 Differential Gene Expression Differential Itgb5 Igf2r L1cam Itga4 Hbegf Pparg Lrp8 Rara Cp M6pr App Vldlr P4hb

Older Slc1a5 Ntm Crlf2

PC ASC Ligands from ASC to Receptors from TNC

Fzd5 Lrp8 Bsg Younger Avp Adcyap1r1 Gabbr1 P4hb Plxnb2 Clu Lrp1 App Smo Igf2r Cst3 Cd44 Itgb5 Itgb1 Differential Gene Expression Differential C1qa M6pr Itgav Fgfr1

Older Nlgn3

ASC TNC Ligands from TNC to Receptors from ASC Younger

App Cd9

Izumo4 Ntm Differential Gene Expression Differential Older

TNC ASC Ligands from ASC to Receptors from VSMC

Fzd2 Fgfr1 Fzd1 Itgb1 Plxnb2 Younger Avp Fzd6 Itga3 Slc1a5 Smo Scarb1 Clu Tfrc Adcyap1r1 Itgav App Lrp8 L1cam Cst3 Nlgn3 Grm3 Ldlr Cacna1a Cp C1qa P4hb Bsg M6pr Rara

Differential Gene Expression Differential Itga5 Itga4 Efemp1 Tgfbr2 Fzd3 Grm7 Erbb2 Tgfbr1 Fjx1 Lrp1 Cd93 Fzd4

Older Gabbr1 Itgb5 Igf2r

ASC VSMC Ligands from VSMC to Receptors from ASC Younger

App

Cd9

Izumo4

Ntm

Hbegf Differential Gene Expression Differential

Crlf2

Tslp Older

VSMC ASC Ligands from CPC to Receptors from ABC

Younger App

H2−Eb1 Ogn

Ctsl Cd74 Differential Gene Expression Differential Mif Older

CPC ABC Ligands from EC to Receptors from CPC

P4hb Plxnb2 Folr1 Younger App Cst3 Itgb5 Bsg Itgav Vldlr Itgb1 Apoe Lepr Itga3 Tgfbr2 M6pr Igf2r Clu Pdgfra Differential Gene Expression Differential Lrp8 Lrp1 Gabbr1

Older Fgfr1

EC CPC Ligands from CPC to Receptors from GABA Younger

App Lrp1b Differential Gene Expression Differential Older

CPC GABA Ligands from GABA to Receptors from CPC

Bsg Younger Fzd6 Avp

Itgb5

Smo Cst3 Fzd7

Fzd4

Nptn Differential Gene Expression Differential Cd47

Gabbr1 Older

GABA CPC Ligands from MG to Receptors from CPC App P4hb Fgfr2 Clu Fzd7 Younger Vldlr Itgav Avp Plxnb2 Bsg Itgb1 Fcgrt Grn Mr1 Folr1 Hfe C1qc Kl Fzd4 Fzd6 Smo Tnfsf13b Pdgfra Tgfbr2 Ryk Differential Gene Expression Differential Tyrobp Lrp8 Itga3 Lepr Fgfr1 B2m Igf2r M6pr Older Lrp1

MG CPC Ligands from CPC to Receptors from mNEUR Younger

App Lrp1b Differential Gene Expression Differential Older

CPC mNEUR Ligands from mNEUR to Receptors from CPC

Fzd6 Younger Itgb5 Cst3

Smo

Bsg Nptn Fzd4

Fzd7

Avp Differential Gene Expression Differential Gabbr1

Cd47 Older

mNEUR CPC Ligands from CPC to Receptors from OLG

Clu Il15 Adipor1 Hmgb2 Cst3 Younger Aimp1 Mag Ttr Aplp1 Itgad Vcam1 App Ddr1 Sdf4 Sulf1 Gsn Glrb Ins2

Ctf1 Enpp2 Fam213a Anxa5 Apoc1 Kdr Nampt Mfge8 Lrp1b

Differential Gene Expression Differential Olfm1 Hdgf Cdh2 Pla2g5 Apoe Glod4 Il11ra1 Stoml2 Trf Itgb5 Tgfb2 Ide

Older App Nenf Vegfb

CPC OLG Ligands from OLG to Receptors from CPC

Itgb5 Gsn Fcgrt Ptpra Ddr1 Aplp1 Bsg

Younger Tm2d1 Avp Lrp6 Hfe Plat Nfasc Itgb1 Clu Kl Vldlr Ctf1 Trf Plxnb2 App Pdgfc Fzd6 Esrra Cst3 Mr1 Tcn2 Jam3 P4hb Itgav Smo Cntn1 Fgfr2 Fzd7 Cd151 Fzd4 Adipor1 C1qa Folr1 Lrp1 Differential Gene Expression Differential Cdh2 Ryk Fgfr1 Lrp8 Creg1 Igf1r Tgfbr2 B2m Lepr Chid1 Apod Notch2 Itga3 Edil3 Pdgfra Olfm1 Gabbr1 App Igf2r Older Cldn3 Apoe Adgrl1 M6pr

OLG CPC Ligands from PC to Receptors from CPC

Itgb5 App Bsg Younger Itgb1 Clu Vldlr Itgav Folr1 P4hb Plxnb2 Cst3 Tgfbr2 Pdgfra M6pr Lrp8 Gabbr1 Apoe Lrp1 Differential Gene Expression Differential Fgfr1 Igf2r Lepr

Older Itga3

PC CPC Ligands from DC to Receptors from ABC Younger

Mif

Cd74

App Differential Gene Expression Differential Older

DC ABC Ligands from EC to Receptors from DC

Itga4 M6pr Bsg Younger Cst3 L1cam Itgb1 Dpp4 Slc1a5 Apoe Lrp1 App Scarb1 Rara Clu P4hb Cd44 Fgfr1 Differential Gene Expression Differential Cxcl12 Tgfbr2 Plxnb2 Tgfbr1

Older Ldlr

EC DC Ligands from DC to Receptors from GABA Younger

App Lrp1b Differential Gene Expression Differential Older

DC GABA Ligands from GABA to Receptors from DC Younger

Bsg

Cst3

Slc1a5

Nptn

Cd47 Differential Gene Expression Differential Older

GABA DC Ligands from DC to Receptors from MG Younger

Cmtm6 P2ry12 Differential Gene Expression Differential Older

DC MG Ligands from MG to Receptors from DC L1cam Nckap1l Clu H2−Eb1 Itgb1 Younger Rara P4hb Grn Fgfr1 App Tgfbr1 C1qc M6pr Lrp1 Tnfrsf13b Tnfrsf1a Tnfsf13b Cd44 Klrk1 Bsg Ctsl Hfe Cd74 Cd86 Klrd1 Differential Gene Expression Differential Tyrobp Il2rg Tgfbr2 Plxnb2 B2m Fcgr1 Fcgrt Older Scarb1

MG DC Ligands from DC to Receptors from mNEUR Younger

App Lrp1b Differential Gene Expression Differential Older

DC mNEUR Ligands from mNEUR to Receptors from DC Younger

Cd47

Cst3

Slc1a5

Nptn

Bsg Differential Gene Expression Differential Older

mNEUR DC Ligands from DC to Receptors from OLG

App Anxa1 Adipor1 Olfm1 Younger Lfng Mag L1cam

Gsn Cntn1 Nenf Cmtm3 Glrb Tgfb1 Tnf Enpp2 Hmgb2 Aimp1 Kdr Clu Sdf4 Lrp1b Hdgf Cxcl16 Cdh2 Cst3 Differential Gene Expression Differential Ly86 Il11ra1 Apoe Il18 Stoml2 Itpr2 Glod4 Anxa5 Itgb5 Il1b

Older Trf App Nampt

DC OLG Ligands from OLG to Receptors from DC

Hfe Igsf6 Gsn Ldlr Itga4 Aplp1 Tgfbr2

Younger Bsg Fcgr1 Plat Tnfrsf1a Olfm1 Itgb2 Clu Cd74 Fgfr1 Trf Ptprc Cd44 L1cam Cst3 Nckap1l Scarb1 Ryr1 Jam3 Lrp1 Fcgrt Cntn1 Klrd1 Slc1a5 Itgax Tac1 Lrp6 Ebp Itgb1 Cd151 P4hb Vac14 Differential Gene Expression Differential C1qa Tlr2 M6pr Ptpra Cdh2 Itgam Dpp4 Efemp1 Il2rg App Cd86 B2m Adipor1 Evi2a Tm2d1 App Rara Tgfbr1 Older Apoe Notch2 Plxnb2 Ptpro

OLG DC Ligands from PC to Receptors from DC

App Scarb1

Younger Itgb1 Tgfbr1 Clu Tgfbr2 M6pr Lrp1 Cd44 Cst3 P4hb L1cam Rara Bsg Fgfr1 Apoe Differential Gene Expression Differential Itga4 Slc1a5 Ldlr

Older Plxnb2

PC DC Ligands from DOPA to Receptors from ABC

Younger Ctsf

H2−Eb1 App

Ctsl Cd74 Differential Gene Expression Differential Mif Older

DOPA ABC Ligands from DOPA to Receptors from EC Younger

Hbegf

Cd9

Izumo4 Differential Gene Expression Differential Older

DOPA EC Ligands from EC to Receptors from DOPA App Adcyap1r1 M6pr Lrp12 Younger Cst3 Igf2r Lrp1 Ryr2 Itgb1 Dcc Apoe Plxnb2 Lrp8 Itgav Adra1b Gabbr1 Clu Pgr Egfr L1cam Fgfr1

Differential Gene Expression Differential P4hb Cxcl12 Bsg Rara Scarb1 Tfrc Older Pparg

EC DOPA Ligands from DOPA to Receptors from GABA Younger

Plat

Lrp1b

App Differential Gene Expression Differential Older

DOPA GABA Ligands from GABA to Receptors from DOPA

Ryr2 Fzd9 Younger Grm4 Avp Grm1 Grm5 Adra1b Cst3 Bsg Cd47 Grm7 Slc7a1 Nptn Differential Gene Expression Differential Grm2 Gabbr1 Ptprj Older

GABA DOPA Ligands from DOPA to Receptors from MG Younger

Hbegf

Csf1r

Csf1

Cd9 Differential Gene Expression Differential Izumo4 Older

DOPA MG Ligands from MG to Receptors from DOPA Lrp1 Scarb1 Cmtm6 Egfr Lrp8

Younger L1cam P4hb Clu Grm5 Pparg Cacna1a Avp Lpar1 Fgfr2 Grm7 Itgav Grn App Sort1 Adra1b C1qc Fzd9 Ryk M6pr Bsg Tnfsf13b Grm1

Differential Gene Expression Differential Tfrc Rara Tyrobp Adcyap1r1 Grm2 Igf2r Plxnb2 B2m Itgb1

Older Fgfr1 Grm4

MG DOPA Ligands from DOPA to Receptors from mNEUR Younger

Plat

Lrp1b

App Differential Gene Expression Differential Older

DOPA mNEUR Ligands from mNEUR to Receptors from DOPA

Gabbr1 Grm1 Younger Bsg Cst3 Fzd9 Adra1b Grm5 Nptn Grm4 Grm2 Slc7a1 Grm7 Avp Differential Gene Expression Differential Ptprj Ryr2 Cd47 Older

mNEUR DOPA Ligands from DOPA to Receptors from OLG

Cst3

Glod4

L1cam Adipor1 Olfm1

Younger Tgfb2

Apoe Mag Clu

Chgb

Aimp1 Cntn1 Vegfb

Il18

Fgf9 Ddr1 Cdh2

Pomc

Ttr Glrb Mfge8

Aplp1

Hmgb2

App Enpp2

Trf

Fgf13

Ide Kdr

Anxa5 Differential Gene Expression Differential Nenf

Nampt Lrp1b Stoml2

Fgf1

Vegfa Cdh2 Icam4

Sdf4

Fam213a Il11ra1 Hdgf

Plat

Txlna Itgb5 Gsn

Cxcl14

Tnr Older Adam9 App

Fgf12

Edil3

DOPA OLG Ligands from OLG to Receptors from DOPA

Tnfrsf21 Rara Cntn4 Gsn Vac14 Adcyap1r1 Bsg Itih3 Itgav Tm2d1 Fgf13

Younger Nlgn3 Aplp1 Gabra4 Cdh2 Grm7 Plxnb2 Avp Slc7a1 Fgfr2 S1pr1 Plat Ptprr Cntn3 Adgrl1 Itgb1 Clu Fzd9 Tspan5 Chid1 M6pr Trf Vipr2 Gpr61 P4hb Cst3 Tpra1 App L1cam Grm2 Jam3 Cntnap1 Lrp8 Grm4 Ptprz1 Cntn1 Esrrg Adipor1 Pparg Cd151 Ptpra Tfrc Ntrk3 Grik2 C1qa Sorl1 Agrn Cacnb1 Amot Cdh2 Differential Gene Expression Differential Ryr2 Cntn2 Nfasc Ptgds Glrb Dcc Lrp1b Erbb4 Creg1 Mag Grin1 Igf1r Efemp1 Lrp6 Scarb1 Grm1 Adra1b Rnase4 Kcnj10 Gria2 Ebp Grm5 Cdh8 Ptprk Fgfr1 Esrra B2m Zfyve27 Lrp1 Ptpro Lrp12 Edil3 Ryk Igf2r Gabbr1 Cacng2 Older App Ntm Olfm1 Egfr Apoe Ptprj Cacna1a Ddr1 Cntn5

OLG DOPA Ligands from PC to Receptors from DOPA

Gabbr1 Itgb1 Lrp1

Younger Itgav Egfr Clu Lrp8 Tfrc Pparg Scarb1 M6pr Plxnb2 Cst3 Rara Lrp12 Fgfr1 L1cam Igf2r Ryr2 Apoe Adra1b Differential Gene Expression Differential P4hb App Adcyap1r1 Dcc Older Bsg

PC DOPA Ligands from EC to Receptors from ABC

Pdgfra P4hb Cst3 Plxnb2 Ackr3 Egfr Younger App Apoe Rara Fgfr3 Lrp1 Clu Cp Adra1b Fgfr1 Ctsl Ldlr Slc1a5 Lepr Tfrc App Bsg Itgav M6pr Mif Itga3 Tgfbr1 Itgb5 Igf2r Ctsf Itgb1

Differential Gene Expression Differential Dpp4 Tgfbr2 Ogn Vldlr Erbb2 Scarb1 Pdgfa Itga5 Adcyap1r1 Gabbr1 Cd44 Cxcl12 Lrp12 Older H2−Eb1 Cd74

EC ABC Ligands from ABC to Receptors from EC Younger Apoe

Izumo4 Tfrc

Hbegf

Differential Gene Expression Differential B2m Cd9

Anxa1 Older

ABC EC Ligands from EC to Receptors from EPC

Ldlr Rara Bsg Cd44

Younger Cxcr4 Fgfr1 Cst3 Ackr3 Adcyap1r1 Cd36 Gabbr1 App Itgb1 Apoe Itgb5 Plxnb2 Lrp1 Itga3 Lrp2 Igf2r Folr1 Clu Cp Ryr2 Scarb1

Differential Gene Expression Differential Lrp8 P4hb Itgav Cxcl12 Tyro3 Tgfbr1 M6pr Erbb2 Fgfr3

Older Tgfbr2 Vldlr

EC EPC Ligands from EPC to Receptors from EC

Younger Izumo4

Tfrc

Hbegf

C3 Fcgrt

Apoe Differential Gene Expression Differential

Cd9

B2m Older

EPC EC Ligands from EC to Receptors from GABA

Nptn Grm5 Tfrc Cst3 App Gabbr1

Younger Itgb1 Itgav Apoe Vldlr Tyro3 Itga5 Lrp1 Clu L1cam Cp Esr1 Ryr2 Avp Cd4 Plxnb2 Lrp8 Igf2r Rspo1 Erbb2 Ldlr Egfr Lrp12 App Itga3 Scarb1 P4hb Ackr3 Serpine1 Pdgfra Differential Gene Expression Differential Fgfr3 Bsg Adcyap1r1 Icam2 Fgfr1 Dcc M6pr Adra1b Plat Pgr Tgfbr1 Rara Itga4 Cxcl12 Tgfbr2 Older Itgb5 Pparg Lrp1b

EC GABA Ligands from GABA to Receptors from EC

Tfrc Avp Gabbr1 Cst3 Cd40 Younger

Nptn Grm3 Fzd6 Apoe Fzd9

Psap Slc7a1 Fzd4 App Fzd2 Clu Fzd1 Adra1b Mif Fzd8 Snx2 Fzd5

L1cam Smo Slc1a5

Differential Gene Expression Differential Izumo4 Ptprj Hbegf Grm5 Grm7 B2m Fzd3 Trf Itgb5

C1qbp Cd47 Bsg Older Hmgb1 Cd9

GABA EC Ligands from EC to Receptors from GLUT

Adra1b Lrp12 Tfrc L1cam Esr1 Younger App Itgav Cst3 Adcyap1r1 Cd44 Tyro3 Gabbr1 Ryr2 Dpp4 Vldlr Lrp8 Apoe Dcc Ackr3 Itgb1 Itgb5 Plxnb2 Scarb1 Rara Pparg Clu Pgr Slc1a5 Igf2r Differential Gene Expression Differential Tgfbr1 Itga3 Ldlr Itga5 Lrp1 Cxcl12 Fgfr1 P4hb Tgfbr2 Bsg Itga4

Older Pdgfra Fgfr3 M6pr

EC GLUT Ligands from GLUT to Receptors from EC

Psap

Younger L1cam

Clu

Snx2 Tfrc Sdf4

App

Hmgb1

Izumo4

C1qbp Differential Gene Expression Differential Cd9 Apoe

Hbegf

Trf

Older Mif

GLUT EC Ligands from EC to Receptors from Hb_VC

Tgfbr2 Lrp8 Younger Cst3 P4hb Itgb1 Gabbr1 Scarb1 Apoe Itgb5 Itgav Lrp1 Clu M6pr Cp App Differential Gene Expression Differential Cxcl12 Tfrc Ackr3

Older Bsg

EC Hb_VC Ligands from Hb_VC to Receptors from EC Younger

Hbegf Cd9 Differential Gene Expression Differential Older

Hb_VC EC Ligands from EC to Receptors from ImmN

P4hb App Younger Gabbr1 Cst3 L1cam Lrp8 Bsg Vldlr Apoe Itgb1 Adcyap1r1 Tgfbr1

Clu M6pr Differential Gene Expression Differential Lrp12 Plxnb2 Lrp1 Older

EC ImmN Ligands from ImmN to Receptors from EC Younger

Izumo4 Cd9 Differential Gene Expression Differential Older

ImmN EC Ligands from EC to Receptors from MAC Tgfbr2 App Cd36 Adcyap1r1 Younger Bsg Cst3 Lrp12 M6pr Slc1a5 Itgb5 Pparg Cd4 Apoe Fgfr1 P4hb Tgfbr1 Itga4 Itgb1 Clu Plxnb2 Egfr Ldlr Scarb1

Differential Gene Expression Differential Rara Tfrc Cxcl12 Cd44 Lrp1 Cp Itgav

Older Gabbr1 Cxcr4

EC MAC Ligands from MAC to Receptors from EC Younger Trf

Tfrc Hbegf

Il16 Cd9 Differential Gene Expression Differential

Izumo4 Older

MAC EC Ligands from EC to Receptors from MG

Csf1r P2ry12 Tgfbr1 Cst3 Itgb5 Scarb1 Younger Gabbr1 Apoe Itgb1 Tgfbr2 App P4hb Clu Tfrc Itgav Rara Hbegf Bsg Cxcr4 Cd44 Fgfr1 Cmtm6 Fgfr3 Lrp12 Plxnb2 Tslp Cd36 Adcyap1r1 Itga4 Esr1

Differential Gene Expression Differential Il34 Egfr L1cam Lrp8 Izumo4 Slc1a5 Pdgfra Ryr2 Igf2r Csf1 Tyro3 Itga5 Treml2 Cyr61 Vldlr Cp Ldlr M6pr

Older Cxcl12 Lrp1 Cd9 Crlf2

EC MG Ligands from MG to Receptors from EC

Tfrc Cmtm6 Fcgrt M6pr Gabbr1 Clu Il2rg Ryk Avp Grm3 Fzd6 Younger Grn Fzd9 Lrp8 Lepr C1qc Fcgr1 Adra1b Apoe P2ry12 Plxnb2 Hmgb1 Ppara Tgfbr2 S100a8 Cd74 Egfr Fzd4 Hmgb2 App Fzd1 App Adcyap1r1 Scarb1 Hbegf Itgav Plxna1 Cxcr4 Stoml2 Itga3 Itga7 Anxa1 Lrp1 Lpar1 Cd276 Tnfrsf1b Fgfr2 Snx2 Fzd2 Hfe Vldlr C1qbp Pdgfrl Fzd8 Trf Tnfrsf1a Cd44 Mr1

Differential Gene Expression Differential Il16 Clec5a Tgfbr1 Izumo4 H2−Eb1 Cacna1a Mif P4hb Igf2r C3 Erbb3 Kl Sdf4 Sort1 Trem2 Esr1 Psap Itgb1 Grm5 Vcam1 Fas Erbb2 C1qa Itga5 Fzd5 Smo Anxa5 Fgfr1 Grm7 Tnfsf13b Fzd3 Fgfr3 Ctsl Pdgfra

Older Rara Tyrobp Selplg L1cam Bsg B2m Cp Cd9

MG EC Ligands from EC to Receptors from MNC

Tgfbr1 Slc1a5 Itga4 Younger Cst3 Ldlr Lrp1 Cxcr4 Itgb5 Apoe Plxnb2 App M6pr Cd36 Clu Tgfbr2 Rara Scarb1 Differential Gene Expression Differential Cxcl12 Cd44 Itgb1 Bsg

Older P4hb

EC MNC Ligands from MNC to Receptors from EC Younger

Il16 Cd9 Differential Gene Expression Differential Older

MNC EC Ligands from EC to Receptors from mNEUR

Nptn Tfrc Grm5 App Cst3 Gabbr1 L1cam

Younger Tyro3 Itgav Apoe Vldlr Adra1b Itgb1 Esr1 Ryr2 Clu Lrp12 Lrp8 Cd44 Lrp1 Folr1 Avp Plxnb2 Itga5 Cxcr4 Ackr3 App Cd4 Erbb2 Cp Dpp4 Scarb1 Rspo1 Igf2r Pgr Dcc Adcyap1r1 Differential Gene Expression Differential Serpine1 Lepr Ldlr Itga3 Egfr Rara Icam2 Itgb5 Slc1a5 Pdgfra Bsg Tgfbr1 Plat Pparg Fgfr1 P4hb Fgfr3 Cxcl12 Tgfbr2

Older Itga4 M6pr Cd36 Lrp1b

EC mNEUR Ligands from mNEUR to Receptors from EC

Tfrc Cst3 M6pr Nptn Gabbr1

Younger Avp Cd40 Grm3 Apoe Fzd6 Psap Fzd9 App Fzd4 Slc7a1 Clu Fzd2 Mif Fzd1 L1cam Adra1b Slc1a5 Snx2 Fzd5 Vcam1 Fzd8 Anxa5 Ptprj Smo

Differential Gene Expression Differential Hbegf Grm5 Izumo4 Grm7 Hmgb2 Fzd3 Itgb5 B2m Cd47 Trf L1cam Hmgb1 Bsg Cp C1qbp Older S1pr1 C1qa Cd9

mNEUR EC Ligands from EC to Receptors from NRP

Adcyap1r1 Fgfr1

Younger App Itgb1 Cst3 Gabbr1 Lrp1 M6pr Plxnb2 Apoe Tfrc Egfr Tyro3 P4hb Scarb1 Clu Differential Gene Expression Differential Tgfbr1 Lrp8 Slc1a5

Older Bsg

EC NRP Ligands from NRP to Receptors from EC Younger

Sdf4

Tfrc

B2m Differential Gene Expression Differential Older

NRP EC Ligands from EC to Receptors from NSC

Tgfbr1 Tyro3 Bsg Younger Cst3 Gabbr1 Lrp8 Tfrc Adcyap1r1 Apoe Scarb1 M6pr Egfr App Clu Itgb1 Itgav Lrp1 Fgfr1 Differential Gene Expression Differential Cxcl12 Plxnb2 Itgb5 Fgfr3

Older P4hb

EC NSC Ligands from NSC to Receptors from EC Younger

Hbegf

Cd9

Izumo4 Differential Gene Expression Differential Older

NSC EC Ligands from EC to Receptors from OEG Cxcr4 Igf2r Itgb1 Tgfbr1

Younger Tyro3 Cst3 Erbb2 Bsg Lrp8 M6pr Tfrc Tgfbr2 Apoe App Rara Lrp1 Ackr3 Ldlr Vldlr Lrp12 Clu Plxnb2 L1cam Adcyap1r1

Differential Gene Expression Differential Itgav P4hb Fgfr3 Cxcl12 Fgfr1 Gabbr1 Scarb1 Slc1a5

Older Cd44 Cp

EC OEG Ligands from OEG to Receptors from EC

Anxa5 Younger Tfrc Hmgb2

Apoe Fcgrt

Izumo4

Il2rg Il16 Differential Gene Expression Differential Hbegf Cd9

B2m Older

OEG EC Ligands from EC to Receptors from OLG

Cst3 Adipor1 Apoe Mag Clu

Avp Itgad

Nampt Cntn1 Cxcl14 Ddr1 Olfm1

Tnfsf10

Younger Glrb

Fam213a Enpp2 Pomc Cntfr Agt

Hdgf Cxcr4

Pgf Tfrc Ide

Aplp1 Gabbr1

Ctf1 Tyro3 Cdh2 Ldlr Fgf1

Adam9 Adcyap1r1

Angptl4 Adra1b Wnt4 M6pr Vegfb

Il2 Lrp12

Anxa1 Igf2r Tslp Itgb1 Ttr

Il15 Lrp8

Mfge8 Itga3 App Egfr Glod4

Sdf4 P4hb

Trf Ackr3 Apoc1 Slc1a5 Hmgb2

Fgf12 Dcc

Stoml2 Ryr2 Vegfa Plxnb2 Rspo1

Cmtm3 Pgr

Differential Gene Expression Differential Apoa2 Pdgfra Tfpi L1cam Vcam1

Tgfb3 Fgfr3

Lfng Cd44 Tgfb2 Itga4 Ly86

Apoc3 Lrp1

Icam4 Esr1 Il18 Rara Spp1

Anxa5 Tgfbr1

Ndp Bsg Tgfb1

Fgf13 Cp

Cdh5 Scarb1 Lpl Tgfbr2 Chgb

Edil3 Fgfr1

S100a8 Vldlr Tnfsf13b Itgav Ppbp

Gsn Grm7

Txlna Grm3 Aimp1 Kdr Cxcl16

Serpine1 Lrp1b

Older Nenf Cdh2 Angpt2 Il11ra1 L1cam

Plat Itpr2

Vegfc Itgb5 Cyr61 App Cxcl12

EC OLG Ligands from OLG to Receptors from EC

Tfrc Fcgrt Gsn Slc40a1 M6pr Tcn2 Aplp1 Ntm Olfm1 Kcnj10 Gabbr1 Avp Il2rg Adipor1 Tek Plat Ryk Grm3 Sorl1 Lgi3 Tpra1 Younger Fzd6 Dpp4 Cmtm5 Ctf1 Cdh2 Fzd9 Clu Lrp8 Agrn Igf1r Tfr2 Trf Itga6 Vac14 App Pdgfc Tlr4 Ppara Fzd4 Cst3 Notch2 Plxnb2 Ptpro Jam3 Tlr3 Lepr Cd74 Cntn1 Egfr Fzd1 Itgav Adra1b Tac1 Ptprz1 Tspan5 Gabra4 Mif Ebp Cd46 Ptpra Vcam1 Itga7 Lrp1b Vldlr Sdf4 Itga4 Amot Adgrl1 Anxa1 Scarb1 Cxcr4 Fgfr2 Lrp1 L1cam Nlgn3 Gria2 Fcgr1 Hbegf Ptger1 Itgam Fzd2 Cd276 Tgfbr2 Adcyap1r1 Hfe Hmgb2 Slc7a1 Itga3 Ephb4 Stoml2 Ager Glrb Nfasc Mr1 Psap Lrp6 Kl Tlr2 Hmgb1 Il1rap Esr1 Ptprj Differential Gene Expression Differential Snx2 P4hb Asgr1 Ptprb C1qbp Itga5 Fzd8 Bmpr1b Izumo4 Ror1 Erbb3 Ldlr Ptprg C1qc Fas Fgf13 Cd44 Anxa5 Fgfr1 Colec12 Igf2r Tnfsf12 Grm5 Itpr3 Lrp5 Cd151 Fzd5 Chid1 Esrra Manf Cd93 Tm2d1 Grin1 Mag C1qa Cacng3 Cacna1a Slc1a5 Cdh2 Cntnap1 Smo Evi2a Ptgds Ptprk Ar Rarb Creg1 Tgfbr1 Tnfrsf1a Cacnb1 Efemp1 Itgb1 Erbb2 Ntrk3 Grm7 Cdh8 Itgb4 Tnfrsf21 Itgb3 B2m Fzd3 Itgb5 Tyro3 Sostdc1 Lrp12 Itgb2 Cacng2 Apod Fgfr3 Cntn2 Zfyve27 Older Edil3 Pdgfra Notch1 Ddr1 App Rara Ddr2 Ptprr P2ry2 Il33 L1cam Tnfrsf12a Bsg Apoe Cp S1pr1 Cd9

OLG EC