We are ready to help! Pioneering science, www.integratedgenetics.com [email protected] personalized service General questions? Call toll-free within the US Understand your cost options Screen for more than Visit our website for your cost estimate and personalized payment options and 877.821.7266 the opportunity to learn about our Moms Helping Moms of Tomorrow initiative. www.integratedgenetics.com/transparency 844.799.3243 Billing and cost questions? Call toll-free within the US Convenient blood draws Getting your blood drawn is easier than 844.799.3243 ever. As a LabCorp company, we have Every Mom Pledge team is ready to answer questions a nationwide network of patient service about your insurance coverage and cost options centers, allowing for convenient access to sample collection. Visit www.LabCorp.com integratedgenetics.com/transparency to find your nearest location. Watch a short video to learn about the test: Genetic counseling integratedgenetics.com/videos Patients with a positive test result may be Sequenom Laboratories offered counseling, and Integrated Genetics 3595 John Hopkins Court offers the largest national commercial network of genetic counselors to help inform San Diego, CA 92121 and support patients.

Sequenom Center for Molecular Medicine, LLC d/b/a Sequenom Laboratories, Every Mom Pledge a wholly owned subsidiary of Sequenom, Inc., is a CAP-accredited and Clinical Laboratory Improvement Amendment (CLIA)-certified molecular diagnostics We believe every mom should have access laboratory dedicated to improving patient outcomes by offering revolutionary to the best possible care. That's why we laboratory-developed tests for a variety of prenatal conditions. Sequenom, Inc. is a wholly owned subsidiary of Laboratory Corporation of America Holdings. work directly with you to make sure our Sequenom®, Sequenom Laboratories™, and MaterniT® are trademarks of testing services are accessible and out-of- Sequenom, Inc. This brochure is provided by Integrated Genetics as an pocket costs are transparent. educational service for healthcare providers and their patients.

Note: This material is provided for general information purposes only. It is not intended as a substitute for medical advice and/or consultation with a physician or technical expert.

REFERENCES 1. Internal data.

A test that analyzes every to tell you more about your baby's health

© 2019 Laboratory Corporation of America® Holdings. All rights reserved. Rep-1038-v4-1019 | L17294-1019-4 Why does every chromosome matter? What makes MaterniT GENOME are how cells transfer genetic different? information as a baby develops, and extra or missing After more than 70,000 tests resulted by Integrated parts of chromosomes, or whole chromosome Genetics, up to 30% of all positive findings could only changes, can severely impact the health of a be detected by MaterniT GENOME methodology.1 baby. Most NIPTs analyze information from select Because most other NIPTs don’t analyze for that 30%, chromosomes. But changes can be found in all they don’t report on it. But that doesn’t mean there’s chromosomes—which is why MaterniT GENOME nothing to report. analyzes them all.

What will MaterniT GENOME tell me? Like most NIPTs, MaterniT GENOME can tell you if you screen positive or negative for 21 (Down syndrome), 18 (), and 13 (), and if you’re having a boy or a girl. But it can also find other chromosomal changes that may go undiagnosed at birth. Having information about these 1 2 3 4 5 6 7 8 9 10 11 12 chromosomal changes before birth can help ensure your baby receives the proper and necessary support.

MaterniT GENOME reports on:

13 14 15 16 17 18 19 20 21 22 X Y : extra copy of a chromosome is present (3 Whole chromosomes analyzed by MaterniT GENOME Any trisomy or monosomy instead of 2) Monosomy: You don’t have to wait missing copy of a until your baby is born chromosome (1 instead of 2) Atypical number of X and/ to learn about his or her Sex chromosome or Y chromosomes beyond health. abnormalities typical female (XX) or male (XY) complement Very small part of the MaterniT® GENOME—a 1 2 3 4 5 6 7 8 9 10 11 12 Partial chromosome chromosome is extra or abnormalities noninvasive prenatal missing test (NIPT)—can provide insights as early as nine Results delivered clearly and quickly 13 14 15 16 17 18 19 20 21 22 X Y weeks into a pregnancy. Results from the MaterniT GENOME test are typically Whole chromosomes analyzed by most NIPTs available within 5–10 days after your sample has been And it has been received in the laboratory. And while some NIPTs give validated to analyze you a risk score, MaterniT GENOME ensures screening every chromosome. results are communicated clearly—as positives or negatives.