TRANSLATING DISCOVERY INTO CURE

A REPORT FROM PENN’S ABRAMSON CANCER CENTER A MESSAGE FROM the Director of the Abramson Cancer Center

Welcome to the latest report of the Abramson Cancer Center of the University of Pennsylvania. This report highlights major accomplishments of the past year including the renewal of the EXCEPTIONAL National Cancer Institute’s Cancer Center Core Support Grant to the University of Pennsylvania with a designation of exceptional, the highest rating possible. This award recognizes the scientific discoveries, multidisciplinary collaboration and commitment to world-class patient care that define our institution. PRECISION I am grateful for the dedication of the 311 cancer center members whose innovative research is changing the face of cancer today, the clinical and administrative staff who support them, the patients who entrust us with their care, the leadership within the university and participating hospitals, and the donors who, in showing their gratitude for our work, challenge us to do more and better, to find tomorrow’s cure today. Our world-renowned innovations attracted the attention of the White House, which launched its cancer ‘moonshot’ initiative at the Abramson Cancer Center on INNOVATION January 15, 2016. This recognition by Vice President Biden results from your contributions. Similarly, the new collaborative Parker Center for Immunotherapeutic Research recognizes the accomplishments and potential of the cancer immunotherapy research featured in this report. As we celebrate these successes, we strive for better — for a day when there doesn’t need to be a IMPLEMENTATION cancer center. Until then, I invite you to learn more about the Abramson Cancer Center and join us in our fight to eradicate cancer.

IMPACT

Chi V. Dang, MD, PhD Director, Abramson Cancer Center John H. Glick, MD, Abramson Cancer Center Director’s Professor contents National Moonshot Initiative EXCEPTIONAL Parker Institute at Penn Boosts Immunotherapy Research An Exceptional Year Ensuring Quality Care 03

Your Cancer is Unique Targeting Cure Seeing the Light PRECISION Bolstering An Immune Response Rays Take Shape Personalized Medicine Takes on Tobacco 15

INNOVATION Treating the Exceptions Tomorrow’s Therapies Today Tracking an Invisible Enemy Basser Center Steers BRCA Research 37

IMPLEMENTATION Beyond Philadelphia The Local Footprint The Global Footprint 55

IMPACT Power of Philanthropy The Power of a Name The Time is Now Inspiring Hope Gift of Hope 71

ABRAMSON CANCER CENTER // EXCEPTIONAL 01

EXCEPTIONAL

ex • cep • tion • al | ik’sepSH( )n( )l |

Forming an exception or rare instance. Unusually excellent. Superior. Extraordinary.

Read within to learn about the groundbreaking science, latest technology and outstanding medical care that once again earned Penn's Abramson Cancer Center the designation of exceptional by the National Cancer Institute in 2015.

03 NATIONAL CANCER MOONSHOT

(l to r): Vice President Joe Biden with Drs. Levine, June and Gutmann INITIATIVE

The Abramson Cancer Center (ACC) was proud to host Vice President Joe Biden as the White House kicked off the National Moonshot Initiative against cancer in January 2016. The initiative is designed to accelerate cancer research to ensure that better prevention and treatment strategies reach patients sooner.

0404 Donald M. O'Rourke, MD; Angela M. DeMichele, MD, MSCE; Chi V. Dang, MD,PhD; Stephen Grubbs, MD; Amy Gutmann, PhD; Vice President Joe Biden; Frances S. Collins, MD, PhD; Howard Krein, MD, PhD; Carl H. June, MD; Robert H. Vonderheide, MD, DPhil

During his visit, Vice President Biden toured a first-of-its-kind research hub at Penn that will serve as the epicenter I LOOK FORWARD TO of our personalized T-cell therapy program. He also met with ACC and Penn physicians and scientists with expertise in immunotherapy, cancer prevention, surgery, genomics and other areas critical to answering cancer’s most WORKING WITH THIS PANEL challenging questions. AND MANY OTHERS INVOLVED

WITH THE MOONSHOT TO Chi V. Dang Appointed to Blue Ribbon Panel The Abramson Cancer Center’s involvement in the Moonshot Initiative will continue through the appointment of MAKE UNPRECEDENTED Director Chi V. Dang, MD, PhD, to the Blue Ribbon Panel charged with steering the effort. The panel includes clinicians, patient advocates, members of the pharmaceutical industry and experts in immunology, cancer prevention, IMPROVEMENTS IN bioinformatics and genomics, among others. PREVENTION, DIAGNOSIS “I’m honored to be joining this diverse group of cancer researchers and physicians, advocates and industry leaders, all of whom represent communities that are essential players working to better prevent and fight the many forms of the AND TREATMENT OF CANCER. disease,” Dr. Dang said. “I look forward to working with this talented panel to inform scientific direction of the Vice President’s Moonshot as we work toward a cure for the millions who are touched by cancer each year.”

The panel will act as a working group of the presidentially appointed National Cancer Advisory Board (NCAB), and, as such, will provide scientific guidance to NCAB, which will convey findings to the National Cancer Institute. In addition to Dr. Dang, ACC member Peter Adamson, MD, of the Pediatric Oncology Program, will serve on the panel.

— Joe Biden “This Blue Ribbon Panel will ensure that, as the National Institutes of Health allocates new resources through the Vice President of the United States Moonshot, decisions will be grounded in the best science,” Vice President Biden said in a news release.

ABRAMSON CANCER CENTER // EXCEPTIONAL 05 PARKER INSTITUTE AT PENN BOOSTS IMMUNOTHERAPY RESEARCH

The University of Pennsylvania is honored to join a first-of- its-kind, national research collaboration to fight cancer with immunotherapy. The Parker Institute for Cancer Immunotherapy unites six of the nation’s top medical schools and cancer

Robert H. Vonderheide, MD, DPhil (l) and Carl June, MD (r) centers around a shared aim to accelerate new discoveries and examine T lymphocytes growing in the laboratory for new ways to kill cancer cells. treatments in cancer immunotherapy.

06 WE ARE

TREMENDOUSLY EXCITED TO

JOIN THIS COLLABORATION, “Working together will enable us to make quicker progress as we translate our laboratory findings into clinical trials,” says Carl June, MD, Richard W. Vague WHICH WILL ALLOW US TO Professor in Immunotherapy and Director of the Abramson Cancer Center’s 1,100 PENN CANCER INVESTIGATE PROMISING Center for Cellular Immunotherapies, who has been appointed overall CLINICAL TRIALS IN 2015 director of Penn’s Parker Institute. NEW IMMUNOTHERAPY The $250 million grant to launch the effort is the largest single contribution ever made to the field of immunotherapy. The funding comes from The AVENUES, OUTSIDE OF OUR Parker Foundation, which was founded by Sean Parker in June 2015 with a INSTITUTIONAL SILOS, IN VERY $600 million gift to spur innovations in the life sciences, global public health and civic engagement. UNIQUE WAYS. Penn will use the funding to set up the Parker Institute at Penn, support 80 PENN laboratory studies and clinical trials, recruit talented faculty and develop early IMMUNOTHERAPY career investigators. An initial investment of $10 to 15 million will grow on CLINICAL TRIALS IN 2015 an annual basis via additional project grants, shared resources and central — Carl H. June, MD funding. Robert Vonderheide, MD, DPhil, Hanna Wise Professor in Cancer Richard W. Vague Professor in Immunotherapy; Director, Center for Cellular Immunotherapies Research and ACC Associate Director for Translational Research, and John Wherry, PhD, Professor of Microbiology and Director of Penn’s Institute for Immunology, serve as co-directors of the institute.

See page 24 for more about immunotherapy discoveries at Penn.

ABRAMSON CANCER CENTER // PROGRESS REPORT 07 AN EXCEPTIONAL YEAR

The past year brought many accolades for Penn’s Abramson Cancer Center, at the forefront of which was the renewal of the National Cancer Institute (NCI) Cancer Center Core Support Grant with a rating of exceptional. This is the highest rating that the NCI awards to cancer centers. The Abramson Cancer Center is one of 69 cancer centers in the United States and one of only 45 comprehensive cancer centers.

040804 NCI

Designated Comprehensive Cancer Center What is the NCI Cancer Centers Program? THESE FUNDS ENABLE The 1960s brought awareness that cancer is a complex disease that requires US TO CATALYZE NOVEL a major influx of resources to understand, prevent, treat and cure. In 1971, President Nixon captured the attention of the oncology community by INTERDISCIPLINARY TEAM signing the National Cancer Act and establishing a National Cancer Program. Fifteen cancer centers were born, including, in 1973, one at the University APPROACHES TO CANCER of Pennsylvania. PREVENTION AND TREATMENT NCI-funded cancer centers can be basic, clinical or comprehensive. A comprehensive cancer center demonstrates expertise in both laboratory THAT HAVE THE POTENTIAL TO AN EXCEPTIONAL YEAR science and clinical research and brings added depth to the way in which researchers share knowledge to solve pressing questions in cancer biology, ADVANCE CANCER SCIENCE treatment and prevention. This hallmark bench-to-bedside approach requires The past year brought many accolades for Penn’s Abramson Cancer tremendous resources and a cadre of dedicated researchers and clinicians AND CARE BEYOND WHAT working together to uncover cancer’s greatest mysteries. Our ultimate mission Center, at the forefront of which was the renewal of the is to translate these discoveries into new ways to cure cancer or prevent CAN BE ACCOMPLISHED IN cancer from developing. National Cancer Institute (NCI) Cancer Center Core Support INDIVIDUAL LABORATORIES. Grant with a rating of exceptional. This is the highest What is the Cancer Center Core Support Grant? rating that the NCI awards to cancer centers. The Size, scope and purpose — three factors distinguish the NCI Cancer Center Core Grant from other cancer research grants. At nearly $7 million/year, it Abramson Cancer Center is one of 69 cancer centers in is one of the largest federal research grants awarded to Penn. Unlike grants that support individual research projects, the core grant funds the leadership, — Caryn Lerman, PhD the United States and one of only 45 comprehensive Senior Deputy Director, Abramson infrastructure and initiatives that define us as a center and help make Cancer Center; John H. Glick, MD, Professor of cancer centers. meaningful discoveries possible. Cancer Research (pictured here with Dr. Dang)

ABRAMSON CANCER CENTER // EXCEPTIONAL 09 What is the Grant Process? What is an NCI Cancer Center? Renewing this grant is no easy feat. Every five years, we VISION COMMITMENT SKILLS RESOURCES ACCOMPLISHMENTS TEAMWORK submit a detailed, structured proposal describing our vision, Six key characteristics define an NCI Cancer Center: accomplishments, capabilities and plans. The proposal is the size of 1 PHYSICAL SPACE: Do we have the labs, the offices  4 CANCER FOCUS: Is our work changing the a book, and contains descriptions and the clinical space to excel in high-level cancer research? medical community’s understanding of the causes, of our research, the people who prevention and treatment of cancer?  2 ORGANIZATIONAL CAPABILITIES: do it and the infrastructure that Who is on our team? How does the organization of the 5 INSTITUTIONAL COMMITMENT: Are cancer makes it all possible. Hundreds center capitalize on our strengths and benefit our and the cancer center priorities for the University of of physicians, scientists and staff community? How do we identify our scientific priorities Pennsylvania, Penn Medicine and Children’s Hospital contribute information on their and plan strategically? of Philadelphia? accomplishments to demonstrate the value of the cancer research 3 TRANSDISCIPLINARY COLLABORATION 6 CENTER DIRECTOR: Does our director enterprise at Penn. & COORDINATION: How do we work together? have the background, leadership skills and vision to What do we accomplish as a team? steer this research enterprise? Is he vested with the The site visit, which follows the authority to do so? submission of the proposal, is an important component of the process. It is an intensive one-day More than the Sum of Our Parts: Research Programs meeting with a team of reviewers As an NCI Cancer Center, we leverage individual research strengths to create a collaborative and dynamic research center. — the doctors, scientists and Our 311 members represent eight schools and 47 departments at Penn. Their work spans laboratories, doctor’s offices, administrators from other cancer community settings and the operating rooms and bedsides of patients at Penn Medicine hospitals, as well as the Children’s centers who volunteer their time to Hospital of Philadelphia. help the NCI evaluate their peers. The site visit is high pressure but Eleven research programs spanning three major areas of research provide an organizational framework for our efforts. also gives us a chance to show what Ten associate directors oversee each area of research, translational research, diversity and outreach, pediatric research, we have accomplished. education and training, shared resources, information technology and administration.

10 WE ALWAYS TRY TO BE HONEST ABOUT THE REAL RESEARCH CHALLENGES WE ARE FACING AND NOT BE SATISFIED THAT WE’VE SOLVED PROGRAMS ALL THE PROBLEMS. WE ARE EARNESTLY LOOKING FOR BETTER NO BASIC RESEARCH: MATTER WHAT WE’VE ACHIEVED. PEOPLE ARE STILL GETTING CANCER. ■■ Immunobiology Program

■■ YOU HAVE TO KEEP MAKING DISCOVERIES. Tumor Biology Program ■■ Tumor Virology Program — Robert H. Vonderheide, MD, DPhil Associate Director for Translational Research; Hanna Wise Professor in Cancer Research CLINICAL RESEARCH: ■■ Breast Cancer Program ■■ Cancer Therapeutics ■■ Hematologic Malignancies Program Sharing Resources: Ensuring that the Latest Tools are Available to All ■■ Melanoma and Cutaneous Malignancies Program Cancer research relies on highly specialized tools. These tools take the form of equipment, techniques ■■ Pediatric Oncology Program and people with unique skills. One of the most valuable ■■ Radiobiology and Imaging Program parts of the NCI Core Grant is the support provided to 11 core facilities or shared resources (“cores”). POPULATION SCIENCE: Cores may require large or specially designed space, ■■ Cancer Control Program specific temperature controls or oversight by highly ■■ trained staff. Their expense, large size or limited Tobacco and Environmental availability render it impossible or nearly so for one Carcinogenesis Program researcher or laboratory to buy, hire or support them on their own. In many cases, there are only a handful of people or places suitable for this work. With core funding, we ensure that the latest biomedical resources are available for communal use by our members.

ABRAMSON CANCER CENTER // EXCEPTIONAL 11 SHARED OUR MISSION IS RESOURCES TO REDUCE THE ■■ Biostatistics Core BURDEN OF CANCER ■■ Cancer Imaging Core What Does this Mean for Our Patients and Our Community? THROUGHOUT OUR ■■ Cancer Metabolism Core As an NCI-funded comprehensive cancer center, we are able to: (developing) REGION, THE NATION ■ ■ ■ Recruit top doctors and scientists. ■ Create opportunities for scientists ■■ Circulating Tumor Material Core from different departments to work (developing) AND THE WORLD, ■■ Offer more clinical trials, including together in a way that encourages ■■ Clinical Cell & Vaccine THROUGH THE some that are only available here or innovation and promotes discovery. in a few places around the country Production Facility ■ DEVELOPMENT OF AN or the world. ■ Stay up-to-date with the ■■ Comparative Pathology Core latest technology and advanced ■■ ■■ Flow Cytometry & Cell INTEGRATED PROGRAM Respond quickly to advances in the biomedical resources. field because we have the people, Sorting Facility ■ OF LABORATORY, the tools and the framework in place. ■ Bring best practices in cancer ■■ Genomic Analysis Core care to the community and other ■■ ■■ Human Immunology Core CLINICAL AND Leverage resources to support parts of the world. creative, cutting-edge research. ■■ Small Animal Imaging Core POPULATION-BASED ■■ Offer exceptional medical care. ■■ Invest in promising ideas through ■■ Transgenic & Chimeric RESEARCH. pilot grants. Mouse Facility

12 THE URGENCY OF REDUCING THE BURDEN

OF CANCER COMPELS US TO BE AT THE FOREFRONT OF

DISCOVERY SCIENCE.

— Chi V. Dang, MD, PhD Director, Abramson Cancer Center 2014 2015 Inpatient Discharges 11,824 11,688

Outpatient Visits 291,272 318,303

ENSURING QUALITY CARE Chemotherapy Treatments 69,887 77,806

Conventional Radiation Therapy Treatments 58,687 58,841 Volume Statistics Patients looking for excellence in cancer care choose Penn’s Abramson Cancer Proton Therapy Treatments 18,739 16,778 Center. Our physicians treat more cancer patients than any other cancer Patients Enrolled in Clinical Trials 9,656 12,172 center in the region. Our patients come from Philadelphia, New Jersey, Delaware and beyond to benefit from Penn’s expertise in cancer surgery, chemotherapy and radiation therapy; personalized approach to recovery; and caring environment. Our wide breadth of clinical trials ensures that our patients have access to the latest and best treatments available. 2014 2015 Research & Training (Federal) $157,126,231 $178,076,005

Sources of Funding Research & Training (Non-Federal) $21,318,432 $19,225,830 Federal funding enables us to quickly translate new research discoveries into Research & Training (Industry/Other) $47,898,994 $53,574,581 treatments and provide personalized, compassionate care. But challenges lie ahead as federal dollars shrink and insurance reimbursement rates drop or Core Grant from the NCI $7,517,199 $7,891,871 won’t cover novel therapies. Commonwealth of Pennsylvania $1,085,000 $1,085,000 Private philanthropic support allows us to continue to lead the way with dramatic Private Philanthropy $35,800,000 $25,140,000 new treatments, breakthroughs in the laboratory and essential supportive programs for our patients and their families. TOTAL $270,745,856 $284,993,287

ABRAMSON CANCER CENTER // PROGRESS REPORT 13 PHOTO GOES HERE PRECISION

pre • ci • sion | pri’siZH n |

The quality, condition or fact of being exact or accurate.

Precision medicine describes advancements in cancer prevention, diagnosis and treatment that target cancer cells more specifically and effectively.

15 YOUR CANCER IS UNIQUE: Kojo S.J. Elenitoba-Johnson, MD, and Jennifer J.D. Morrissette, PhD, in the Center for Personalized Diagnostics Precision Medicine Personalizes Diagnosis and Treatment

Anyone who grew up on television can imagine a medical future in which perfect diagnosis is obtained by swallowing an x-ray pill or using a handheld scanner. While we are not there yet, new developments in cancer research are coming closer to turning this creative vision into a reality.

041604 Recent years have brought the revelation that cancer is not just one disease. All cancers WITH DR. ELENITOBA-JOHNSON AT THE share a common characteristic ­— unhealthy cells growing and dividing at a pace that is HELM, OUR FUTURE HAS NEVER BEEN hard to control and harmful to healthy body functioning. Why this happens, where it MORE PROMISING. ARMED WITH starts and travels, and how to control it vary tremendously from cancer to cancer and PERSONALIZED DIAGNOSTICS, PHYSICIANS person to person.

CAN APPLY GENETIC FINDINGS IN A The words "personalized medicine" or precision medicine describe an approach PROACTIVE WAY TO TAILOR CANCER to medical care that relies on specific information about a person’s genetic makeup TREATMENTS. THIS IS THE KEY TO or the cellular characteristics of an individual’s disease to aid in diagnosis and treatment. PERSONALIZED ‘PRECISION’ MEDICINE. Precision also describes advancements in surgery and radiation therapy that target cancer cells more thoroughly and precisely.

Learn more about the ways in which we are personalizing cancer treatment and care, and why a comprehensive cancer center is — David B. Roth, MD, PhD Simon Flexner Professor and Chair of Pathology and Laboratory Medicine; uniquely suited to bring the latest treatments Director, Penn Center for Precision Medicine from bench to bedside.

ABRAMSON CANCER CENTER // EXCEPTIONAL 17 TARGETING CURE: Personalized Diagnosis Improves Treatment Options

Cancer is a disease of cells — abnormal cells dividing, growing and multiplying. Why this happens is largely a mystery, but we know that, in many cases, the story begins with a gene. A change in a gene interferes with healthy cell processes and causes cancer.

041804 The study of cancer genetics dates back more than 50 years to the discovery of the Philadelphia chromosome, a genetic difference in the cells of patients with chronic myelogenous leukemia, by Penn’s Peter C. Nowell, MD, Professor Emeritus of Pathology and Laboratory Medicine. Dr. Nowell’s breakthrough revealed a link between genetics and cancer and launched a field that has CPD GENETICS WILL BE CRITICAL CONTRIBUTED TO opened the door to better and more precise ways to treat cancer.

Penn’s ACC upped its investment in cancer genetics in 2012 by helping IN THE ESTABLISHMENT 4,000 establish Penn's Center for Personalized Diagnosis (CPD). In 2015, Kojo S.J. PATIENT DIAGNOSES Elenitoba-Johnson, MD, joined Penn as the CPD’s founding director, replacing OF PROPER DIAGNOSIS. THAT’S IN LESS THAN David B. Roth, MD, PhD, Chair of Pathology and Laboratory Medicine, who WHERE EVERYTHING STARTS. 3 YEARS served in this capacity during the start-up period.

Genes provide important clues for accurate medical diagnosis. Over the past YOU’RE NOT GOING TO GET 20 years, researchers have found genes that are active in cancer and developed TARGETING CURE: drugs to “target” them. While chemotherapy overpowers cancer with sheer THE RIGHT TREATMENT IF THE strength, targeted therapies attack strategically. They are intended to modify or DIAGNOSIS IS NOT RIGHT. Personalized Diagnosis Improves fix biological processes that encourage cancer cell growth. As a result, they may cause less harm to healthy cells, which means fewer treatment-related side effects GENETICS GIVES US A VERIFIABLE Treatment Options for patients. The CPD uses DNA sequencing to test tissue and blood samples in order to METRIC FOR A REPRODUCIBLE match patients with therapies. Using genetics for diagnosis offers advantages Cancer is a disease of cells — abnormal cells dividing, over traditional microscope-driven analysis. According to Dr. Elenitoba-Johnson, DIAGNOSIS — ONE THAT IS growing and multiplying. Why this happens is largely “A lot of biology is gray. The distinction between normal and abnormal can be MORE OBJECTIVE AND BOTH challenging to recognize.” a mystery, but we know that, in many cases, the In the coming year, Dr. Elenitoba-Johnson aims to focus on lymphoma diagnosis, QUALITATIVE AND QUANTITATIVE. story begins with a gene. A change in a gene interferes the subject of his own research, and forge tighter alliances with other cancer — Kojo S.J. Elenitoba-Johnson, MD research groups. Looking to the future, he would like to use the CPD to explore Peter C. Nowell, MD, Professor; Director, with healthy cell processes and causes cancer. the genetics of drug resistance. Center for Personalized Diagnostics

ABRAMSON CANCER CENTER // EXCEPTIONAL 19 SEEING THE LIGHT: Precision Surgery Research Glows

I WAS ALWAYS FRUSTRATED WHEN YOU WOULD TELL

A PATIENT THEY WERE CURED AND THEN THEIR CANCER

WOULD COME BACK. I FELT THAT, AS SURGEONS, IT

WAS OUR RESPONSIBILITY TO DO MORE, TO MAKE SURE

THAT WE GOT THE ENTIRE CANCER OUT.

— Sunil Singhal, MD Assistant Professor of Surgery

2020

250+ THIS IS TRULY THE TIP PATIENTS ENROLLED IN PRECISION SURGERY OF THE ICEBERG. IT'S A CLINICAL TRIALS NEW FIELD BUT THERE’S A cancer surgeon enters the operating room with two goals: to find the cancer and to remove all of it. Neither is clear-cut. Advancements in radiology have A LOT WORK THAT resulted in tumors being diagnosed at earlier stages and smaller sizes than in STILL HAS TO COME the past. Surgeons rely on their eyes and hands to identify cancerous masses Surgery is the front-line that can be as tiny as one to two millimeters. FROM THIS. of cancer treatment. It is Once the cancer is found, removal can task even the most experienced doctor. The human body doesn’t mirror a coloring book with clearly delineated lines. often the first stop on a The margins of tumors can be faint and uneven. Surgeons work with the utmost care and precision to ensure that they extract all the cancer. — Sunil Singhal, MD treatment journey that may Assistant Professor of Surgery These limitations were unsettling to Sunil Singhal, MD, Assistant Professor of include chemotherapy or Surgery, who looked for a way to enhance surgery, a technique that would radiation. Nearly half of all help surgeons do their jobs better. His insight led to the development of near-infrared (NIR) imaging, currently being tested in clinical trials. If approved people treated for cancer at by the Food and Drug Administration, NIR imaging will be the first surgical advancement of its kind in several decades — one that could bring a new level Penn will undergo surgery of precision to the operating room. at some point, usually to find Inspired by glowing decals on the ceiling of his daughter’s bedroom, Dr. Singhal envisioned cancer cells lighting up in a way that might make them more easily out more about the tumor, recognizable. NIR imaging attempts to do just that. It relies on a special dye that or to remove the cancer or is intended to reach the tumor and, when lit with a near-infrared camera, glows green. The camera’s rays come from light, rather than radiation, eliminating the surrounding lymph nodes. side effects or concerns sometimes associated with radiation.

ABRAMSON CANCER CENTER // EXCEPTIONAL 21 MEET Preliminary testing on canine patients at Penn’s School of Veterinary Medicine and THE TEAM current trials with human patients show promise. If approved, this technique could be useful in the treatment of a number of cancers including lung and prostate, Sunil Singhal, MD according to Dr. Singhal. Assistant Professor of Surgery; The future rests with the dye. Different dyes target the cancerous area in different ways Director, Thoracic Surgery and may provide varying levels of accuracy. Dr. Singhal is looking beyond his early dyes Research Laboratory and partnering with industry to develop new generation dyes. Improved dyes may be brighter and more specific so that surgeons can see smaller numbers of cells.

In order to develop this line of research, the ACC has established a new Center for Precision Surgery led by Dr. Singhal. The center, which opened in October 2015, Thomas J. Guzzo, MD, MPH brings together surgeons who specialize in different cancers and provides a platform Associate Professor of Surgery; for surgical innovation. To date, Dr. Singhal and the team of surgeons have tested Vice Chief, Urology imaging technology in the operating room on more than 250 patients enrolled in surgical clinical trials. The group has also discovered many common challenges. “The center is allowing us to address problems faster because we are working together and in a cross-disciplinary fashion,” says Dr. Singhal, who continues to perfect his technique, looking for ways to enhance the glow. John Y.K. Lee, MD Associate Professor of Neurosurgery; Medical Director, Cancer Types Under Investigation ■ ■ ■ Penn Gamma Knife Center, ■ Bladder ■ Gastric/Stomach ■ Pancreatic ■ ■ ■ Pennsylvania Hospital ■ Brain ■ Kidney ■ Peritoneal ■■ Breast ■■ Lung ■■ Prostate ■■ Ear, Nose & Throat ■■ Melanoma ■■ Sarcoma ■■ Fallopian Tube ■■ Ovarian ■■ Uterine

22

A TUMOR THAT HAD NOT

BEEN VISIBLE ON THE

TRADITIONAL CAT SCAN OR

PET SCAN WAS GLOWING LIKE

THE EMERALD CITY. IF I

HAD GONE TO ANY OTHER

FACILITY THAT DIDN’T HAVE

THE GREEN DYE THAT'S

ATTRACTED TO LUNG

CANCER, THEY MAY NEVER

HAVE FOUND THE

SECOND TUMOR SO I THANK

GOD EVERY DAY THAT I

WENT TO PENN.

— Francie Howat Lung Cancer Patient

ABRAMSON CANCER CENTER // EXCEPTIONAL 23 BOLSTERING AN IMMUNE RESPONSE: New Investigational Immunotherapy Treatments for Cancer

Our immune system is one of the most powerful forces in our bodies. When it’s healthy, it protects us from disease and fights infection. Yet, this protection is imperfect. Disease reaches us, and, in the case of cancer, overpowers the immune system, allowing unhealthy cells to live, grow and expand.

042404 THE MAJOR REWARD OF

CANCER RESEARCH IS THE ABILITY TO MAKE

A DIFFERENCE FOR PATIENTS.

— Carl H. June, MD Richard W. Vague Professor in Immunotherapy; BOLSTERING AN Director, Center for Cellular Immunotherapies IMMUNE RESPONSE: Imagine a drug or therapy that could treat disease by helping the immune New Investigational Immunotherapy system do its job better. That is the idea behind immunotherapy — treatments Treatments for Cancer designed to boost the immune system. This new kind of investigational cancer treatment is taking its place besides surgery, chemotherapy, radiation therapy and targeted therapy as what some Our immune system is one of the most powerful forces in our call a “fifth pillar” of cancer treatment. Unlike targeted therapies designed to fix a breakdown in a gene, immunotherapy is intended to bolster the immune bodies. When it’s healthy, it protects us from disease and system — by empowering the cells that fight infection or disabling antigens, fights infection. Yet, this protection is imperfect. Disease the obstacles in their path. The Abramson Cancer Center is at the forefront of this research. Our efforts reaches us, and, in the case of cancer, overpowers the involve physicians and scientists from multiple research programs and immune system, allowing unhealthy cells to live, departments and rely on the game-changing technology available through our NCI-funded core facilities. The following highlights provide a glimpse into this grow and expand. exciting area of research.

ABRAMSON CANCER CENTER // EXCEPTIONAL 25 Multiple myeloma, cancer of the bone marrow, is also the source of enthusiasm in CAR T research. The standard treatment for this brutal cancer is a bone marrow transplant. The risks associated with transplant are high and increase with age, a significant challenge for multiple myeloma patients who tend to be older. Early use of CAR T has been encouraging with some patients experiencing remissions of their disease. CAR Drives Immunotherapy Research Increasing CAR T research is a high priority for the coming years. To accommodate T cells on are on the frontline of our body’s defenses — searching and destroying this, the Abramson Cancer Center just expanded its cell manufacturing facilities anything that causes illness or infection. Since 2001, Carl H. June, MD, and with the February 2016 opening of the new Novartis-Penn Center for Advanced colleagues have sought ways to adapt a person’s T cells and turn them into an Cellular Therapeutics focused on CAR T research. Bruce L. Levine, PhD, Barbara elite force more capable of fighting cancer. and Edward Netter Professor in Cancer Gene Therapy, who directs this facility and Their vision first began to be realized in 2010 when an investigational chimeric its parent Clinical Cell and Vaccine Production Facility, notes that the new facility antigen receptor (CAR) therapy was reported to have successfully treated an will enable expansion of research and manufacturing to potentially “be able to aggressive form of leukemia. By last year, CAR T-cell therapy (CAR T) was in testing treat hundreds of patients with new therapies based on technology we developed for patients with several forms of blood cancer including non-Hodgkin lymphomas here at Penn.” and multiple myeloma and in patients with solid tumors, including ovarian and In 2014, Penn received breakthrough therapy designation from the U.S. Food and pancreatic cancers and mesothelioma. Drug Administration for the treatment of pediatric acute lymphoblastic leukemia During clinical trials of CAR T-cell therapy, a person’s white blood cells are removed, using the CAR T-cell therapy now known as CTL019, the first accomplishment of this reengineered to target cancer and then returned to the body to go to work. The kind by an academic center rather than a pharmaceutical company. Breakthrough bolstered T cells have been shown to multiply and hunt the cancerous enemy. This designation provides a pathway to expedite the development and review of drugs can happen quickly in blood cancers where the T cells immediately connect with the for life-threatening conditions by the FDA. Dr. June hopes to see these treatments cancer. In a solid tumor cancer, they must travel to the target — a tumor that may be become available at community hospitals in the future. He envisions Penn and isolated or hard to reach. A small antibody “serves as a nose that helps identify the Philadelphia potentially becoming leaders in cell therapies, akin to how Stanford enemy,” according to Janos L. Tanyi, MD, PhD, an Assistant Professor of Obstetrics University and Palo Alto have been leaders in information technology. and Gynecology, who directs CAR T clinical trials in ovarian cancer. “That’s the good thing about being a large cancer center. We’re always going to Early studies in ovarian cancer demonstrated that the T cells found the tumor, and so be at the next generation of things, at the cutting edge, trying to make it better,” far the patients have tolerated the treatment well. The next step is a phase 2 clinical he said. Dr. June credits the Abramson Cancer Center’s rich resources and diverse trial to determine if the treatment can shrink tumors. expertise to helping advance this area.

26

IT HAS MADE THE WHOLE

COMMUNITY OF MYELOMA

DOCTORS INTERNATIONALLY

TAKE NOTE AND TRY TO

THINK ABOUT HOW THIS

HAPPENED AND ARE THERE

OTHER APPROACHES FOR THIS

DISEASE AND OTHER DISEASES

THAT CAN HELP TARGET THE

TUMOR CELLS.

— Edward A. Stadtmauer, MD Professor of Medicine

ABRAMSON CANCER CENTER // EXCEPTIONAL 27 Cutting the Brakes: Fighting Cancer with Checkpoint Inhibitors T cells are the warriors of the immune system, attacking invaders that cause disease. When the body struggles against cancer, even the most vital T cells can WE APPRECIATE THE encounter trouble — resistance that blocks their attack. This resistance takes the COMPLEXITY OF CANCER form of molecules on the surface of cancer cells. These molecules, called immune checkpoints, act like a brake, stopping the T cell attack. AND I THINK THAT'S WHY Researchers hope that, by deactivating immune checkpoints, the T cells will continue and succeed in their mission of killing cancer cells. Checkpoint inhibitors, THIS NOTION OF TEAM drugs designed to do just this, are being tested in clinical trials. IS SO IMPORTANT. THE “We want to cut the brakes to unleash the power of the immune system to fight cancer,” says Daniel Powell, PhD, Research Associate Professor of Pathology and COMPLEXITY REQUIRES Laboratory Medicine, whose research focuses on ovarian cancer. He sees promise for immunotherapy with ovarian cancer because ovarian cancer patients with MULTIPLE MINDS TO COME active immunity in their cancer fare better than those lacking this immunity. TOGETHER TO TACKLE THE Dr. Powell and colleagues aim to cut the brakes on two key checkpoints — PD1 and CTLA4 — known to be active in ovarian cancer. Treatments to tackle each PROBLEM OF CANCER. separately have had some success in other cancers but Dr. Powell theorizes that a double blockade targeting both at once might provide the power needed to take on ovarian cancer.

Tara Gangadhar, MD, Assistant Professor of Medicine, and Lynn Schuchter, MD, C. Willard Robinson Professor of Medicine, conduct related research in — Lynn M. Schuchter, MD melanoma. Findings from their studies testing PD1 blockade have appeared in C. Willard Robinson Professor of Medicine; notable journals, including The Lancet and the New England Journal of Medicine. Chief, Division of Hematology/Oncology

28

The Promise of Vaccines Vaccines are back. The Abramson Cancer Center’s vaccine research efforts build on UNLIKE CHICKEN POX AND INFLUENZA, CANCER decades of strength developing vaccines based on laboratory science done here at Penn. Unlike the cancer prevention vaccine widely administered to preteens, cancer ANTIGENS ARE NOT COMPLETELY FOREIGN. WE NEED treatment vaccines attempt to cure or prevent recurrence of cancer in people who already have or are at high risk of getting cancer. Cancer treatment vaccines work in TO TEACH THE IMMUNE SYSTEM TO RECOGNIZE different ways but the goal is the same: a safe and effective immune response. THESE ANTIGENS. DNA vaccines are at the forefront of this effort, impressive both in preliminary testing and in the collaborative story behind them. Robert H. Vonderheide, MD, DPhil, who steers translational research for the cancer center, describes the way in which tumor — Janos L. Tanyi, MD, PhD virologists, immunobiologists and clinical researchers have worked together, “Two basic Assistant Professor of Obstetrics and Gynecology science programs collaborated and delivered state-of-the-art vaccines to the clinical research programs.”

Dr. Vonderheide leads development of the TERT vaccine, which is being tested in clinical trials in patients with pancreatic, lung and recurrent breast cancers. Unlike CAR T, which is being studied in patients with end-stage cancers who have exhausted other Dr. Vonderheide is also working with the Basser Center for BRCA to develop a treatments, this DNA vaccine is given to people who have responded to standard new vaccine that could prevent breast and ovarian cancer in women who have not therapies but are at high risk of relapse. The TERT vaccine targets telomerase, an had cancer but are at high risk due to hereditary genetic mutations. He adds, enzyme that is overactive in cancer cells. Unique to Penn, TERT vaccine research “If we can prevent relapse, we can begin to think even bigger about preventing evolved through a partnership with Inovio Pharmaceuticals and relies in large part on cancer altogether.” technology developed by David Weiner, PhD, Professor of Pathology and Laboratory Abramson Cancer Center researchers also continue to test dendritic cell vaccines Medicine and Co-Leader of the Cancer Center’s Tumor Virology Program. for ovarian cancer. These vaccines use the patient’s own tumor cells to activate Another potent DNA-based vaccine showing great promise in research targets dendritic cells to launch an immune attack. According to Janos L. Tanyi, MD, PhD, HPV-based head and neck cancers. Clinical trials led by Charu Aggarwal, MD, MPH, Assistant Professor of Obstetrics and Gynecology, who directs these clinical Assistant Professor of Medicine, and Roger B. Cohen, MD, Professor of Medicine and trials, “The dendritic cell vaccination relies on the unique antigen profile of the ACC Associate Director for Clinical Research, started two years ago with favorable patient's tumor. Each patient's tumor expresses unique proteins (tumor-associated results. Dr. Aggarwal says, “These results are in line with our hypothesis that DNA antigens) that can be recognized and attacked by the immune system. Thus, immunotherapy would lead to activation of the immune system. We are excited to immune therapy can be designed specifically (personalized) against each patient's follow these patients and learn about long-term results with this immunotherapy.” own cancer, maximizing the potential for success."

ABRAMSON CANCER CENTER // EXCEPTIONAL 29 RAYS TAKE SHAPE: The Precision of Proton

Powerful beams of protons reach cancer cells in the tiniest and most sensitive corners of the body. Proton particles form the shape of the tumor or target area, minimizing damage to the surrounding area. Proton therapy evokes images of futuristic science but is, in fact, one of the latest innovations in radiation therapy, a form of cancer treatment used by doctors for more than 100 years.

04303004 35,517 PROTON THERAPY TREATMENTS IN 2014 – 2015 Learn more about the Roberts Proton Therapy Center at PennProtonTherapy.org.

THIS IS A STAR WARS

FACILITY. THE THINGS WE

ARE DOING ARE SO Founded in 2010, the Roberts Proton Therapy Center is the largest of its kind in the U.S., able to treat over 100 adults and children a day in five treatment rooms. This new form of radiation has been effective in treating BEYOND OTHER PLACES. people with lung, GI, prostate, pediatric and central nervous system cancers, including some who come to Penn for retreatment after other treatments have failed. WE HAVE EVERYTHING

AVAILABLE IN EVERY The Proton Advantage The precise nature of proton therapy results in less harm to surrounding healthy cells, a key advantage when MODALITY AVAILABLE. treating parts of the body that are hard to reach or near critical organs. More precision also means fewer side effects. Cancer treatment’s side effects, often caused by damage to healthy cells, can be unpredictable, THE FUTURE IS HERE. disabling and a source of significant anxiety. Minimizing side effects results in a better experience for patients. Lastly, proton therapy is very safe, so much so that people who have maximized their allowable doses of traditional radiation may still be eligible for proton therapy.

Even the best technology can be improved. “We’ve been the global leader in advancing the technology of proton therapy,” says James M. Metz, MD, Chair of Radiation Oncology. ACC radiation oncologists have worked with industry to advance proton use in soft tissue imaging and develop pencil beam proton scanning.  — James M. Metz, MD Henry K. Pancoast Professor; Pencil beam scanning achieves an even higher level of precision and is likely to become the standard of care Chair of Radiation Oncology for proton therapy moving forward.

ABRAMSON CANCER CENTER // EXCEPTIONAL 31

PROTONS ARE AMAZING. THEY WERE A

LOT EASIER ON MY BODY. I’D ALREADY

HAD ANOTHER KIND OF RADIATION

AND THE SIDE EFFECTS OF PROTON

WERE MUCH LESS. WHEN IT WAS TIME

TO DO THE PROTON TREATMENT, THE

Expanding the Reach of Proton Therapy TECHNICIANS WOULD SAY, ‘OK, BEAM As we continue to enhance the proton therapy experience at Penn, we recognize UP.’ I USED TO LAY ON THE TABLE, that not everyone can come to Philadelphia. Our commitment extends to helping people in other parts of the country and the world benefit from this treatment. IMAGINING THAT I WAS IN A BATTLE AND Penn radiation oncologists lead a multi-level training program for medical staff from other proton facilities. The program includes a web-based component and FIGHTER PILOTS WERE ZAPPING THE trainings here and at the participants’ facilities. ALIEN CANCER CELLS. THIS ATTITUDE According to Dr. Metz, “It’s very novel. It’s extending Penn’s proton reach globally by bringing what we are doing to other places. We’ve had 450 individuals come to GOT ME THROUGH. Penn in the past year so it’s been a remarkable exchange of knowledge.”

For the future, Dr. Metz and colleagues are considering ways to bring proton therapy to the community. Smaller, less expensive proton therapy rooms in

suburban or rural settings could reach more people, including those who have — Kim Vernick trouble coming to the city for regular treatment. Pancreatic Cancer Patient

32 ABRAMSON CANCER CENTER // EXCEPTIONAL 33 PERSONALIZED MEDICINE TAKES ON TOBACCO

Tobacco treatment programs provide a lifeline to many who struggle with addiction, yet the same treatments work better for some smokers than for others. Why is this? How do we know which approach to try? Pioneering work by Caryn Lerman, PhD, Senior Deputy Director of the Cancer Center and John H. Glick, MD, Professor of Cancer Research, is helping answer these questions.

043404 Caryn Lerman, PhD Senior Deputy Director, Abramson Cancer Center; John H. Glick, MD, Professor of Cancer Research

Recent findings published in The Lancet Respiratory Medicine suggest a role PERSONALIZED for personalized medicine in making treatment choices. In a multi-center randomized trial of more than 1,200 smokers, Dr. Lerman and her team found that a genetic biomarker indicating how quickly people metabolize MEDICINE TAKES ON (or break down) nicotine can predict how well they will respond to different medications for tobacco addiction. TOBACCO Biomarkers provide important clues because they can be measured objectively and used to make predictions about future treatment success. In this case, the biomarker identified the participants as normal or slow Tobacco treatment programs provide a lifeline to many who struggle metabolizers of nicotine. Dr. Lerman found that normal metabolizers were more likely to succeed in quitting with the help of the prescription with addiction, yet the same treatments work better for some medication varenicline, but not the nicotine patch. Slower metabolizers benefited more from the nicotine patch and reported more side effects with smokers than for others. Why is this? How do we know which varenicline. This finding is the first of its kind and could offer new guidance approach to try? Pioneering work by Caryn Lerman, PhD, for clinicians who treat tobacco addiction. “These findings point to a very simple algorithm to help smokers and their Senior Deputy Director of the Cancer Center and John doctors choose the best medication for them,” said Dr. Lerman, “Because H. Glick, MD, Professor of Cancer Research, is helping this biomarker is easy and inexpensive to measure, biomarker testing prior to quit smoking treatment could be a viable strategy to improve quit rates and answer these questions. reduce cancer risk.”

ABRAMSON CANCER CENTER // EXCEPTIONAL 35 36 INNOVATION

in • no • va • tion | in ’vāSH( )n |

The introduction of something new. A new idea, method or device.

Innovation defines our research at many levels, from new approaches to treatment to enhanced focus on populations, diseases or scientific questions that have the potential to change the face of cancer care.

37 TREATING THE EXCEPTIONS: Helping Patients with Rare Cancers

Cancer research is expensive. The most exciting discoveries often require years of effort and financial investment — resources that can be found when a cancer affects large numbers of people. But what about less common cancers? Where is the momentum to cure a disease that lacks political and financial capital? And what does that mean for people living with these cancers?

38

THERE ARE A LOT OF These are the questions faced by doctors who treat rare cancers. Marcia Brose, MD, PhD, Associate Professor of Otorhinolaryngology – INVESTIGATORS WHO HAVE Head and Neck Surgery, refers to the world of rare cancers as the “land of misfit toys.” The misfits are the dedicated doctors and scientists who IDEAS THAT ARE READY TO specialize in rare cancers. They care for patients with mesothelioma, sarcomas, rare blood cancers and neuroendocrine disease, among others. GO. SOME OF THEM HAVE They are often academically isolated, lacking resources or close colleagues who study and treat the same disease. PROGRAMS UP AND RUNNING. Rare can mean either an uncommon cancer or a cancer with unusual THE CENTER FOR RARE circumstances such as resistance to standard treatment or a specific gene or biomarker. Doctors who want to try new drugs for these cancers or believe CANCERS AND PERSONALIZED that an already approved drug might work for their patients often encounter difficulty accessing these agents or time-consuming administrative hurdles. THERAPY IS HELPING THEM How do you design a clinical trial with only a few patients?

TAKE IT TO THE NEXT LEVEL. These challenges were the impetus for the creation of the Center for Rare Cancers and Personalized Therapy, a new center designed to expand treatment options for people who have exhausted standard therapies for their diagnosis. Dr. Brose, who directs the center, drew inspiration from her work with patients who have advanced thyroid cancer.

Advanced thyroid cancer is uncommon and difficult to treat. Dr. Brose,1 who  — Marcia S. Brose, MD, PhD Associate Professor of Otorhinolaryngology – is also a geneticist, sought answers for her patients through genetic analysis of Head and Neck Surgery tumors and from drawing parallels to other cancers. Her research resulted in the Food and Drug Administration (FDA) approval of sorafenib, a drug used in liver and kidney cancers, to treat advanced differentiated thyroid cancer patients. Sorafenib is the first effective treatment for advanced thyroid cancer to be approved in more than 40 years.

1 EDITOR’S NOTE: Dr. Brose received consulting fees and research funding from The Bayer Group and Onyx Pharmaceuticals, the makers of sorafenib.

ABRAMSON CANCER CENTER // EXCEPTIONAL 39 MY PRIMARY PHYSICIAN SENT ME TO DR. BROSE, WHO WAS LEADING A CLINICAL TRIAL THAT

SHOWED A LOT OF PROMISE. SHE AND HER TEAM CARE ABOUT PATIENTS’ QUALITY OF LIFE AND WORK

TIRELESSLY TO MANAGE THE MEDICATIONS AND THEIR SIDE EFFECTS. DR. BROSE GAVE ME A

PRECIOUS GIFT, THE GIFT OF TIME — MORE TIME FOR LAUGHING, WORKING, LIVING, FOR LOVE AND BEING

LOVED. I HAVE MORE TIME NOW, BECAUSE OF DR. BROSE AND HER TEAM’S RESEARCH.

— Rosanne Nicewinter Thyroid Cancer Patient

After this initial success, Dr. Brose began calling colleagues who might benefit from what her team had learned. They shared stories and discovered that, while their patients have different diagnoses, they face many of the same hurdles in their efforts to treat them effectively. With the support of the ACC, a center for rare cancers was born.

Dr. Brose and her team meet with investigators and provide technical support to help start clinical trials for small groups of patients. Dr. Brose says, “There are a lot of investigators who have ideas that are ready to go. Some of them have programs up and running. We are helping them take it to the next level.” There is also a benefit to bringing together investigators who otherwise do not have funding for their studies. By working together, the Center for Rare Cancers and Personalized Therapy helps groups share resources to run clinical trials that otherwise would not be feasible. When possible, they work with Penn’s Center for Personalized Diagnosis (CPD), an advanced genetic profiling facility, to match patients with trials.

Dr. Brose’s goal is to help more patients benefit from clinical trials. She points out that a major cancer center provides “a rich fertile ground to build a program like this,” both because of the availability of physicians and patients, and the resources and leadership commitment to support the effort.

While start-up resources came from the ACC, Dr. Brose hopes that continued support will come at least in part from philanthropy: “We’ve identified the need. We see where we need to go. The only thing that is preventing us from getting there quicker are the funds to continue to staff the program for all the disease groups.”

40 I AM SO GRATEFUL TO HAVE

FOUND THE ABRAMSON CANCER CENTER

AND DR. MARCIA BROSE, WHOSE LOVE

OF SCIENCE IS MATCHED ONLY BY HER

COMPASSION AND SHEER DETERMINATION

(l to r): Bruce L. Levine, PhD; Geoff Watson; and Marcia S. Brose, MD, PhD at the opening TO FIND SOLUTIONS FOR HER PATIENTS. celebration of the Center for Rare Cancers and Personalized Therapy RESEARCH IS THE WAY FORWARD. AND IT

NEEDS RESOURCES. PHILANTHROPY IS THE

Treatment Journey Crosses New Frontiers KEY TO KEEPING THE RESEARCH GOING, Canadian Geoff Watson travels from Ontario, Canada to Philadelphia for treatment at the Abramson Cancer Center. Since his diagnosis with a rare, advanced thyroid AND THAT IS WHY I GIVE. cancer in 2009, Geoff’s treatment journey has crossed country lines and been guided — Geoff Watson by the novel therapies and advanced genetic analysis available through the Center Thyroid Cancer Patient; for Rare Cancers and Personalized Therapy and the Center for Personalized Diagnosis. Partner in Hope

ABRAMSON CANCER CENTER // EXCEPTIONAL 41 TOMORROW’S THERAPIES TODAY: The TCE Challenge

Solving cancer requires teamwork — scientists from multiple disciplines working together in research that spans the laboratory, the clinic and the community. At its best, we take what we learn in one area and apply it in another. This is translational research.

Nowhere is this interconnectedness more apparent than within our translational centers of excellence (TCEs). Conceived by ACC Director Chi V. Dang, MD, PhD, this model approach mobilizes groups of doctors and scientists focused on the same disease to solve a pressing question or problem. Existing TCEs focus on breast cancer, hematologic malignancies, lung cancer and pancreatic cancer and more are planned.

044204 The Goal is 2-Prevent Breast Cancer Recurrence WE WANT TO PREVENT RECURRENCE. Treatment for breast cancer is often successful but there is no definitive way to predict WHEN YOU ARE A PATIENT if or when the disease will return. Add to the challenge, recurrent breast HERE, YOU FEEL AS IF cancer is often unlike the original cancer and not necessarily responsive to the same treatments and is currently incurable.

YOU ARE PART OF THE Breast TCE co-leaders Angela DeMichele, MD, MSCE, Jill and Alan Miller Associate Professor in Breast Cancer Excellence, and Lewis A Chodosh HEALTH CARE TEAM, WITH MD, PhD, Professor and Chair of Cancer Biology and Associate Director A NURSE PRACTITIONER for Basic Research, believe that the answer may lie in understanding dormant cells — cells that remain after treatment in some women but AVAILABLE TO FIELD are not visible. Dormant cells look and act differently from primary or recurrent breast cancer cells, and are able to persist for 20 years or more, QUESTIONS OR DISCUSS evading the body’s attempts to eliminate them.

CONCERNS WHENEVER The 2-Prevent team uses laboratory models that are engineered to look and act exactly like human cancer in order to understand the NECESSARY. biology of dormant breast cancer cells and to discover how to kill them. They have identified a way to look for dormant cells in bone marrow, and have launched a large-scale national clinical trial to follow women who are at high risk for breast cancer to return. They are also testing both targeted drugs and novel immunotherapeutic vaccines to — Sara Gowing Angela M. DeMichele MD, MSCE Breast Cancer Survivor; prevent recurrence in women who are at high risk, including those with Jill and Alan Miller Associate Professor Partner in Hope BRCA mutations. in Breast Cancer Excellence

ABRAMSON CANCER CENTER // EXCEPTIONAL 43 Hematologic Malignancies TCE 25% 4% PENN MEDICINE NATIONAL WE WANT TO LEARN AS MUCH AS WE AVERAGE CAN ABOUT EACH PERSON’S CANCER. The Hematologic Malignancies TCE builds on the recognition that the more we know about an individual’s cancer, the more likely we are to treat it successfully. The main priority of PANCREATIC CANCER PATIENTS ENROLLED the TCE is to analyze the genetics of the cancerous cells of IN CLINICAL TRIALS THE TRANSLATIONAL all patients with leukemia and lymphoma to ensure that each CENTERS OF EXCELLENCE person receives the best treatment for their unique cancer. Members work with the Center for Personalized Diagnosis INITIATIVE HAS BEEN A to streamline collection, analysis and reporting of cancer patient samples.

SIGNATURE PROGRAM OF “The more we understand about the genomics and the genes THE CANCER CENTER OF of each individual, the more we can personalize the therapy for them,” says Edward Stadtmauer, MD, Professor of THE PAST FOUR YEARS. THE Medicine, who co-leads the Hematologic Malignancies TCE with Martin P. Carroll, MD, Associate Professor of Medicine. FRAMEWORK IS A TEAM

APPROACH WITH A CLEAR Lung Cancer TCE THERE IS HOPE IN IMMUNOTHERAPY. GOAL IN MIND — TO BRING The Lung Cancer TCE focuses on offering better treatment options for people with this often fatal diagnosis. The TCE DISCOVERIES TO PATIENTS. team, led by Steven M. Albelda, MD, William Maul Measey Professor of Medicine, and Corey J. Langer, MD, Professor of Medicine, believed early on in the promise of immunotherapy for lung cancer, predicting what has now become the standard of care for hard-to-treat lung cancers. In addition to helping people with lung cancer benefit from — Robert H. Vonderheide, MD, DPhil immunotherapy, the TCE team seeks both to understand Hanna Wise Professor in Cancer Research; Associate Director why immunotherapy works better for some patients than for Translational Research others, and to explore other targeted approaches.

44 Drs. Anil K. Rustgi (l) and Robert Vonderheide (r) Pancreas Attack WE RESPOND IN AN EMERGENCY. Several years THE MAJORITY OF PANCREATIC ago, a rapidly rising death rate brought pancreatic cancer to the forefront of our research. The Pancreatic Cancer TCE, which has CANCER PATIENTS WHO evolved into a newly formed pancreatic cancer research center, mobilizes some of our finest physicians and scientists to find HAVE SURGERY WILL RELAPSE answers that will save lives. The priorities are simple: to test new WITHIN IN A YEAR. WE drugs in the lab, to develop a blood test or screening that would aid in early detection and to quickly deploy findings to the clinic.

ARE ACTIVELY WORKING TO Pancreatic cancer spreads early. Only 20% of people with pancreatic cancer are eligible for surgery. For those who have surgery and DEVELOP HIGHLY SENSITIVE even more for those who do not, hope rests in drug and radiation therapies — often new or experimental treatments available only BLOOD TESTS TO NON-INVASIVELY in the form of a clinical trial. Our goal is to have every patient on DETECT CIRCULATING TUMOR a clinical trial. The ACC is already well above the national average for pancreatic cancer patients on clinical trials with 25% on trial CELLS AS A BIOMARKER TO compared to a national average of 4%. For example, a promising recent trial led by Jeffrey Drebin, MD, PhD, HELP PHYSICIANS IDENTIFY John Rhea Barton Professor and Chair of Surgery, and Peter PATIENTS AT HIGHEST RISK OF O’Dwyer, MD, Professor of Medicine, found that supplementing standard treatment with high doses of vitamin D interfered with RELAPSE. cancer cell growth. The TCE is led by Robert H. Vonderheide, MD, DPhil, Hanna Wise Professor in Cancer Research; Anil K. Rustgi, MD, T. Grier Miller Professor of Gastroenterology and Genetics; and Dr. O’Dwyer, Dr. Erica Carpenter (l), points out a pancreatic who collectively bring expertise in immunology, experimental — Erica L. Carpenter, MBA, PhD cancer patient's circulating tumor cells to Lab Manager, Director, Circulating Tumor Material Laboratory therapeutics and gastrointestinal cancer. Stephanie Yee (r).

ABRAMSON CANCER CENTER // EXCEPTIONAL 45 TRACKING AN INVISIBLE ENEMY: Elusive Ovarian Cancer

Impressive advances have been made in the early detection, screening and prevention of cancer. But some cancers elude detection. With no clear early signs, ovarian cancer is usually diagnosed in later stages when women have little hope for cure. Penn’s ACC is launching a multi-pronged attack to find answers that will prevent or improve the prognosis for the over 500 women in the Greater Delaware Valley who are diagnosed with this disease each year.

044604

WE HAVE THE POTENTIAL TO Within the past year, the ACC has worked with the Department of Obstetrics and Gynecology to BE THE EPICENTER FOR reinvigorate ovarian cancer research at Penn. By channeling the resources and multidisciplinary TRACKING AN OVARIAN CANCER RESEARCH. expertise uniquely available at an NCI-funded comprehensive cancer center, we aim to learn as INVISIBLE ENEMY: WE HAVE ALL THE IMPORTANT much as possible about this silent killer. Founded in 2007, the Penn Ovarian Cancer Research PIECES SITUATED UNDER Center focused primarily on immunotherapy — until Elusive Ovarian Cancer this past year when Deborah A. Driscoll, MD, Luigi THE SAME UMBRELLA FOCUSED Mastroianni, Jr. Professor and Chair of Obstetrics and Gynecology, and Mark A. Morgan, MD, John J. Mikuta, Impressive advances have been made in the early detection, screening ON ONE CLINICALLY MD, Professor of Gynecologic Oncology, with support and prevention of cancer. But some cancers elude detection. from the Abramson Cancer Center, set out to create a IMPORTANT AND BIOLOGICALLY more open and collaborative research enterprise. With no clear early signs, ovarian cancer is usually diagnosed in They recruited Ronny Drapkin, MD, PhD, an CHALLENGING CANCER. accomplished scientist with the energy and vision to later stages when women have little hope for cure. Penn’s build a dream team of researchers from different fields

ACC is launching a multi-pronged attack to find answers that working together to find answers in ovarian cancer. In only a few months, Dr. Drapkin has begun to will prevent or improve the prognosis for the over transform the center. He has forged a connection with the ACC’s Basser Center for BRCA and strengthened 500 women in the Greater Delaware Valley who are — Ronny Drapkin, MD, PhD Franklin Payne Associate Professor ties to the Wistar Institute, a neighboring cancer diagnosed with this disease each year. of Gynecologic Oncology center located on the Penn campus.

ABRAMSON CANCER CENTER // EXCEPTIONAL 47 Priorities range from basic to clinical research, addressing topics such as non-coding RNAs, vascular biology, novel experimental model systems and new targeted therapies. The center's doctors and scientists bring expertise in gynecologic oncology, surgery, pathology, translational research and immunology. Their efforts draw on sophisticated tools such as avatar models of ovarian tumors, a growing tumor bank and advanced immunotherapeutic resources.

Dr. Drapkin adds to these strengths with his groundbreaking research into the origins of ovarian cancer. Where does the tumor start? In order to find cancer early, doctors need to know where to look, a path that has been difficult to trace in ovarian cancer. Dr. Drapkin’s work contributed to the understanding that many ovarian cancers originate in the fallopian tubes, a discovery that has changed patient care and the way researchers are approaching this cancer.

“Looking at the tubes has become critical for managing patient care. New experimental model systems are also emerging that will provide investigators the leverage they need to effectively attack this tumor from the research bench. It’s been a paradigm shift in the field,” notes Dr. Drapkin. He sees this line of research developing with the ultimate goal of establishing a screening test for use in prevention and early diagnosis, akin to how the Pap smear has worked in cervical cancer.

48 (l to r): Mark A. Morgan, MD, John J. Mikuta, MD, Professor of Gynecologic Oncology; Ronny Drapkin, MD, PhD, Franklin Payne Associate Professor of Gynecologic Oncology; Deborah A. Driscoll, MD, Luigi Mastroianni, Jr. Professor and Chair of Obstetrics and Gynecology; Janos L. Tanyi, MD, PhD, Assistant Professor of Obstetrics and Gynecology

SCIENCE IS MOVING AT

SUCH A RAPID PACE THAT

IT IS VERY HARD FOR

ANY ONE SINGLE LAB OR

PERSON TO ATTACK A

PROBLEM IN ITS ENTIRETY.

IT REQUIRES PEOPLE WITH

DIFFERENT EXPERTISE

AND VISIONS TO ADDRESS

IT COMPREHENSIVELY.

— Ronny Drapkin, MD, PhD Franklin Payne Associate Professor of Gynecologic Oncology

ABRAMSON CANCER CENTER // EXCEPTIONAL 49 BASSER CENTER STEERS BRCA RESEARCH

The 1990s brought the discovery of the relationship between the BRCA1 and BRCA2 genes and cancer. Changes (or mutations) in these genes run in families, and those who inherit them are significantly more likely to develop certain cancers, notably breast, ovarian and prostate cancers. This awareness launched a field of medical research dedicated to understanding, preventing and treating BRCA-related cancers.

045004 THE PHILANTHROPIC GIFTS THAT WE HAVE RECEIVED

HAVE ABSOLUTELY ACCELERATED OUR WORK IN THE FIELD AND

ENABLED US TO GET THINGS DONE THAT WE WOULDN’T HAVE

2012-2015 OTHERWISE BEEN ABLE TO DO. OUR GOAL IS TO KEEP REACHING $9.2 M FOR IMPROVED PREVENTIVE STRATEGIES AND BETTER THERAPIES TOTAL GRANTS AWARDED AND TO DO IT AS QUICKLY AS POSSIBLE.

— Susan M. Domchek, MD BASSER CENTER STEERS Executive Director, Basser Center for BRCA; BRCA RESEARCH Basser Professor in Oncology

FY15 The 1990s brought the discovery of the relationship between the BRCA1 In 2012, through the support of Mindy and Jon Gray, the Abramson Cancer $2.8 M Center established the Basser Center for BRCA. Led by Executive Director and BRCA2 genes and cancer. Changes (or mutations) in these genes GRANTS AWARDED Susan Domchek, MD, Basser Professor in Oncology, the Basser Center is the first center of its kind wholly devoted to advancing research on BRCA so that run in families, and those who inherit them are significantly more carriers of these genetic mutations can live longer, healthier lives. likely to develop certain cancers, notably breast, ovarian and The center hosts monthly conferences for providers and researchers, grants research funds and awards the annual Basser Global Prize, established by prostate cancers. This awareness launched a field of medical Shari and Len Potter, to an influential researcher in the field. During the past research dedicated to understanding, preventing and year, the center has strengthened its ovarian cancer research efforts through a collaboration with Penn’s Ovarian Cancer Research Center, led by new Trish Palen, Basser Administrative Coordinator (l) treating BRCA-related cancers. director Ronny Drapkin, MD, PhD (refer to article on page 46). and Dr. Susan M. Domcheck (r)

ABRAMSON CANCER CENTER // EXCEPTIONAL 51 PREVENT BRCA-RELATED CANCERS. Robert H. Vonderheide, MD, DPhil, Hanna Wise Professor in Cancer Research and Associate Director for Translational Research, and David Weiner, PhD, Professor of Pathology and Laboratory Medicine, aim to prevent BRCA-related cancer through immunotherapy. Vaccines developed in Dr. Weiner’s lab are being tested in people with early stage cancers, laying the groundwork for future studies focused on cancer prevention among people with BRCA mutations.

INCREASE ACCESS TO GENETIC TESTING. Selected Areas of Research Seek to: Angela R. Bradbury, MD, Assistant Professor of Medicine, researches ways to make genetic testing more readily available to those who may benefit from it. DISCOVER MORE EFFECTIVE TREATMENTS FOR BRCA-RELATED CANCERS. Dr. Domchek’s research led to the 2014 Food and Drug EXAMINE WHY TREATMENTS WORK. Basser researchers seek to improve treatment success by understanding why some tumors are resistant to Administration approval of olaparib to treat advanced ovarian chemotherapy. Roger A. Greenberg, MD, PhD, Associate Professor of Cancer Biology, leads an innovative cancer in women with BRCA1 and BRCA2 mutations. This translational project involving multiple investigators and laboratories. Drs. Greenberg, Lin Zhang, Andy Minn, marked the first approval of a drug specifically targeting Warren Pear and colleagues are examining chemotherapy resistance at the molecular level and developing BRCA1-and BRCA2-related tumors. Ongoing research looks at novel ways to overcome barriers to treatment success. why these drugs work better in some carriers than others, and why certain tumors may be resistant to the therapy. An annual scientific symposium, hosted by the Basser Center, brings these awardees and other leaders in the field together to learn from each other and share ideas for future research directions. According to Dr. UNDERSTAND TUMOR DEVELOPMENT Domchek, “We feel like the best way to move forward is to do it together with other scientists. This is consistent AND BEHAVIOR. with Vice President Biden’s new ‘moonshot’ initiative.” Katherine L. Nathanson, MD, Professor of Medicine and Outreach helps spread the word about the value of genetic counseling and options for reducing and managing Genetics and ACC Associate Director for Population cancer risk. The center hopes to educate people who are at higher risk of BRCA mutations, such as men and Science, and colleagues use genetic sequencing to examine women of Ashkenazic Jewish descent who are at least ten times more likely than the general population to how other genes interact with BRCA-related tumors. Their carry mutations in these genes. Dr. Domchek adds, “The important thing is to know your family history, to know findings are increasing our understanding of why some if you are of Jewish descent and to have a conversation with your physician.” women with ovarian cancer respond better to treatment than others. To learn more about BRCA mutations and genetic counseling, visit Basser.org or call 215.662.2748.

52

IF WE CAN SAY AT THE END OF TEN

YEARS THAT WE HAVE MORE

NEW DRUGS, BETTER PREVENTIVE

OPTIONS AND ARE GETTING

MORE OF THE PEOPLE WHO NEED

TESTING TESTED, THEN WE’VE DONE

A GOOD JOB. WE ARE WELL ON

OUR WAY IN ALL OF THOSE AREAS.

— Susan Domchek, MD Executive Director, Basser Center for BRCA; Basser Professor in Oncology

ABRAMSON CANCER CENTER // EXCEPTIONAL 53 54 IMPLEMENTATION

im • ple • men • ta • tion | ,impl m n’tāSH( )n |

The process of putting a decision or plan into effect. Execution. In science, the process of integrating research and findings to enhance health care policy and practice.

Read within to learn how our commitment to sharing the latest in cancer prevention, diagnosis and treatment extends beyond these research facilities and hospitals to the Greater Delaware Valley and internationally.

55 BEYOND PHILADELPHIA: Abramson Cancer Center’s Footprint

Cancer is not just a Philadelphia story. It touches people everywhere. And so our work extends beyond the parameters of our urban medical campus to neighboring communities, suburban and rural affiliate hospitals and globally. Through teaching, research and care, we share the best of what is available at Penn. Each interaction is a learning opportunity for us as well, enriching our understanding of the subtlety and complexity of cancer.

5604 WE HAVE AN OBLIGATION TO BRING GOOD CANCER CARE TO THE UNDERSERVED, WHETHER IT’S IN 35% ONCOLINK USERS WEST PHILADELPHIA OR EAST AFRICA.. FROM OUTSIDE THE U.S. — Lawrence N. Shulman, MD ACC Deputy Director for Clinical Services; Director of the Center for Global Cancer Medicine; Professor of Medicine ABRAMSON CANCER CENTER Affiliate hospitals connect with us to offer patients seamless access to resources and clinical trials. Our LOCATIONS global efforts link us to the Middle East, China, Rwanda, Botswana, Tanzania, the Caribbean and other countries ■■ Chester County Hospital around the world. ■■ Hospital of the University of Pennsylvania Our footprint is digital as well. OncoLink, our award- ■■ Lancaster General Health winning cancer information website, connects ■■ Penn Medicine Cherry Hill approximately 300,000 people around the world with ■■ Penn Medicine Radnor information, support and links to resources each month. Since its birth in 1994, OncoLink has created a virtual ■■ Penn Medicine Valley Forge living room for sharing cancer information in a safe ■■ Penn Presbyterian Medical Center space. The site is moderated by physicians and nurses, ■■ Pennsylvania Hospital and available in Spanish and English. ■■ Perelman Center for Advanced Medicine ■■ Roberts Proton Therapy Center ■■ ONCOLINK.ORG Smilow Center for Translational Research Educating and supporting patients, caregivers and ■■ Virtua Health System medical professionals since 1994.

ABRAMSON CANCER CENTER // EXCEPTIONAL 57 THE LOCAL SPOTLIGHT ON FOOTPRINT: CHESTER COUNTY HOSPITAL Beating the Odds Runs in Serving the Greater Delaware Valley Our Family Chester County Hospital joined Penn Medicine in 2013. A highly coordinated cancer treatment program enables their patients to see doctors at Penn or Chester County Hospital. Completely integrated medical records facilitate this process. Two patients described how this integration resulted in exceptional care for their family.

In the spring of 2014, life changed dramatically for Pati Disanti and THE RELATIONSHIPS WITH OUR VARIOUS Kimberly Pearson. Pati was diagnosed with stage I ovarian cancer and shortly after surgery to remove a sizable tumor from her ovaries, her sister PENN HOSPITALS ARE HIGHLY INTEGRATED Kim was diagnosed with stage III ovarian cancer. AND ENABLE US TO MAKE THE THINGS Pati and Kim were both successfully treated at Chester County Hospital by Robert Giuntoli II, MD, Associate Professor of Clinical Obstetrics THAT WE HAVE HERE MORE AVAILABLE TO and Gynecology, and are examples of how patients in this area are benefitting from advanced therapies and innovative cancer care available PATIENTS ELSEWHERE. locally. As part of Penn Medicine’s Abramson Cancer Center, Chester County Hospital and its dedicated team of physicians, clinicians and care providers offer women with complex cancer the region’s best cancer care.

With early detection, state-of-the-art screenings, accurate diagnosis, — Lawrence N. Shulman, MD ACC Deputy Director for Clinical Services; Director of the Center for cutting-edge treatments and access to genetic testing, research, clinical Global Cancer Medicine; Professor of Medicine trials and support groups — we’re bringing the cure within reach.

58

AS SISTERS, WE NEVER EXPECTED TO FACE

CANCER TOGETHER, BUT THAT’S WHAT

HAPPENED WHEN WE WERE DIAGNOSED

WITH OVARIAN CANCER, ONE RIGHT AFTER

THE OTHER. CHESTER COUNTY HOSPITAL

WAS HERE FOR US, RIGHT HERE AT HOME.

WE HAD THE SAME DOCTOR, SAME TEAM,

AND MOST IMPORTANTLY, THE SAME

OUTCOME. THANKS TO PENN, WE ARE

SURVIVORS. THAT’S A KIND OF SISTERHOOD

ALL ITS OWN..

— Pati Disanti (l) and Kimberly Pearson (r) Ovarian Cancer Patients

ABRAMSON CANCER CENTER // EXCEPTIONAL 59 SPOTLIGHT ON PENNSYLVANIA HOSPITAL Finding Strength through Art and Mindfulness The cobblestone streets of a historic Philadelphia neighborhood and the nation’s oldest hospital provide the backdrop for one of the Abramson Cancer Center’s most innovative support programs. Walkabout combines art and mindfulness to offer cancer patients a unique therapeutic approach to handle the stress, fear and sadness that are often part of the cancer experience. It is just one of the innovative programs at the Joan Karnell Supportive Care Program

at the Abramson Cancer Center at Lisa (l) and Vivian (r) Ortiz Walkabout Participants Pennsylvania Hospital.

60 Walkabout The eight-week program is open to people who are in treatment or have recently completed treatment. The majority of the program sessions begin with a guided walk around the neighborhood. During the walk, participants use digital cameras provided by the program to photograph images that capture their attention — maybe a flower, a gate or the architectural detail of a building. They also practice mindfulness — a therapeutic approach developed at the University of Massachusetts 35 years ago that encourages a very deliberate approach to “being in the moment.” Mindfulness has proven effective in reducing stress and anxiety, especially in people grappling with illness.

The program is led by Caroline Peterson, MA, ATR-BC, LPC, a licensed counselor and art therapist who has studied mindfulness. She explains, “The program contextualizes life. It reminds us that we are here for now. We are mortal. We are part of something continual over time. It’s very powerful.” Caroline sees the group as practicing — practicing creativity, practicing photography, practicing mindfulness and, most of all, practicing openness to experience, a valuable coping skill for people living with or recovering from cancer.

Val, who uses the walk to photograph bright things, says: “That’s what I’m attracted to. Even though it’s cloudy, there are some bright spots.” This is Val’s second bout with cancer, and she wishes that programs like this had been available the first time around, 23 years ago. Another participant, Vivian, brings her sister-in-law Lisa with her to the class. They work on their art independently, sharing supplies and encouraging each other. Vivian enjoys the chance to meet new people and appreciates the way the Cancer Center includes caregivers in support programs.

After the walk, the group returns to a room aligned with a colorful display of art materials and filled with the comforting aroma of a supper that can be enjoyed as an activity break at any time during the session. As the participants work, the pages of their art workbooks are transformed into beautiful collages incorporating photos taken in past weeks, scraps of decorative paper and their own drawing and writing. Some choose to revisit a work-in-progress while others are inspired to start something new. The evening Val Roach concludes with a group mindfulness meditation exercise. Walkabout Participant

ABRAMSON CANCER CENTER // EXCEPTIONAL 61

FROM THE TIME OF MY SPOTLIGHT ON DIAGNOSIS, I NEVER LANCASTER GENERAL HEALTH ASKED, ‘WHY ME?’ New Partnership Improves Options The Abramson Cancer Center enhanced its INSTEAD, I ASKED HOW presence in central Pennsylvania this past year when Lancaster General Health (LG Health) I COULD USE THIS joined Penn Medicine. LG Health, known EXPERIENCE TO HELP for excellent clinical care, now benefits from the access to research and medical technology OTHERS. THAT’S WHERE available at a top academic medical center. Cancer care will continue to flourish at the I’VE BEEN WITH MY Ann B. Barshinger Cancer Institute at Lancaster General Health, a state-of-the-art facility JOURNEY. that exhibits a new model of integrated care — with prevention, screening, treatment, education and survivorship care all under one roof. Melanie’s story is just one example of the impact high quality medical practice — Melanie Lung Cancer Patient can have on individual lives.

62 Melanie’s Story It started as a cough that wouldn’t go away. Melanie’s adult daughters began researching cancer programs and scheduled a consultation with a doctor By the end of June 2013, 49-year-old Melanie in Philadelphia. Around the same time, LG Health hosted an open house for its new Barshinger Cancer had been to the doctor several times for what Institute. Melanie toured the facility with her family, liked what she saw and scheduled an appointment she thought was allergies. A return to a former with one of the physicians. After meeting the lung cancer team, she chose the Barshinger Cancer Institute longtime family doctor brought answers. for her care.

“My doctor knew me well and suspected that Melanie’s lung cancer was diagnosed at stage III. She underwent six rounds of chemotherapy and 31 days something else was going on. She sent me for of radiation therapy. The three tumors that were located in the center of her chest have disappeared. She is a chest x-ray,” Melanie said. The x-ray revealed grateful to be alive and cancer-free. a spot that her doctor wanted to examine more During her treatment, Melanie took advantage of the Barshinger Cancer Institute's support programs, closely with a CT scan. Before Melanie had a including yoga classes and the Cancer Rehab and Exercise Program (Ca.R.E.), which provides free exercise chance to schedule the scan, she ended up in the therapy at local YMCAs. “The programs helped me regain stability and strengthen my lungs, which enabled emergency room at Lancaster General Hospital. me to return to work,” she said. “My x-ray came back on a Friday. By Saturday, Melanie credits the warmth and support of the Barshinger Cancer Institute staff with helping her maintain I was having extreme difficulty breathing, and a positive attitude. “From my nurse navigator, Amy Jo, to my infusion and radiation teams, and everyone by early Sunday, I was having an emergency I met throughout my treatment, I was surrounded by kindness. I’ve made good friends throughout this CT scan. The emergency room doctor broke experience, and they gave me the inspiration to fight this disease.” Motivation also came in the form of family. the news that I had lung cancer. My family drove “My husband Doug and I are blessed with six grandbabies. Our oldest was six years old at the time, and home in shock. I had been a smoker for more I promised myself that I would make it to his high school graduation.” than 30 years, but still, we were not expecting this. No one gives you a handbook that tells Melanie has shared her story with other patients diagnosed with lung cancer, in hopes of inspiring optimism you what to do.” and strength.

ABRAMSON CANCER CENTER // EXCEPTIONAL 63 SPOTLIGHT ON PENN PRESBYTERIAN MEDICAL CENTER OUR GOAL IS TO PROVIDE Multidisciplinary Mesothelioma Care No one wants to be told they have cancer but a diagnosis with A MULTIDISCIPLINARY a known environmental cause can be especially hard to accept — even more so APPROACH TO THIS when the exposure came from home, neighborhood or work. This is often the case with mesothelioma, a rare form of cancer that develops in the lining of the chest COMPLEX, HARD-TO-TREAT or abdomen. The primary cause of mesothelioma is exposure to asbestos, a chemical used in many DISEASE AND TO FOSTER industries during the 20th century. The latency period between exposure to asbestos and RESEARCH IN NOVEL AND mesothelioma diagnosis can be very long, as much as 40 years. Not everyone who has been exposed to asbestos will develop mesothelioma but, for those who do, treatment INNOVATIVE THERAPIES options are limited and often ineffective. The Penn Mesothelioma and Pleural Program, based at Penn Presbyterian Medical THAT WILL HOPEFULLY Center, seeks to change this. This dedicated multidisciplinary clinical and research effort combines the latest scientific research, the finest medical care and access to IMPROVE OUTCOMES AND supportive services in one patient-centered program. Led by Evan W. Alley, MD, PhD, SOMEDAY PROVIDE a medical oncologist, and Charles Simone II, MD, a radiation oncologist, this unique program attracts people from all over the country.

A CURE. Patients benefit from the very best in coordinated care, beginning with the first visit — when they may see a medical oncologist, lung specialist, surgeon and radiation oncologist on the same day. A patient navigator serves as a single point of contact and helps connect patients to other supportive services — including counseling,

— Evan W. Alley, MD, PhD mindfulness therapy, yoga and nutrition support — available through Penn’s Clinical Associate Professor of Medicine Abramson Cancer Center.

64 The program’s multidisciplinary research is guided by the Abramson Cancer Center’s Lung COMMUNITY Cancer Translational Center of Excellence, and focuses on improving treatment options THE INFORMATION ON THE INTERNET DRIVES for people with mesothelioma. The emphasis is on bringing immunotherapy to patients, but other WAS VERY SCARY. IT SAID MESOTHELIOMA RESEARCH targeted approaches are explored as well. The WAS INCURABLE AND TERMINAL. THE The Cancer Center’s mesothelioma program’s multidisciplinary research is guided efforts extend to community-based by the Abramson Cancer Center’s Lung Cancer MESOTHELIOMA GROUP AT PRESBY ASSIGNED research as well. Since 2009, Penn Translational Center of Excellence, and focuses researchers have partnered with on improving treatment options for people ME A TEAM THAT PROJECTED AN AIR OF community leaders in suburban Ambler, with mesothelioma. PA to address concerns about the high A recent clinical trial led by Dr. Alley found CARING AND PROFESSIONALISM. THEY rates of disease resulting from exposure to asbestos through manufacturing that the drug pembrolizumab, an immune GAVE US HOPE. checkpoint inhibitor (refer to article on page 28 companies central to the town’s for more information on this immunotherapeutic economy from the late 19th century to approach), was effective in treating patients with — Walter Merth the late 1970s. mesothelioma, with 76% of study participants Mesothelioma Patient (pictured with his son, David Merth) Penn scientists from multiple disciplines seeing improvement or stability in their disease. have worked closely with the community “This study provided an early glimpse of the to understand their questions and potential benefits of using pembrolizumab in develop a program of research to find patients with malignant pleural mesothelioma,” answers. Key cancer center members notes Dr. Alley. “More research and trials will be involved in this research include medical occurring, which we hope will provide further anthropologist Fran Barg, PhD, and grounds for optimism.” environmental toxicologists Ian Blair, Another exciting area of research, led by PhD, and Trevor Penning, PhD, who Steven M. Albelda, MD, William Maul Measey direct the Penn Superfund Research Professor of Medicine, focuses on intrapleural and Training Program Center, an immunotherapy approaches developed at Penn. unprecedented, large-scale, community- Doctors hope to improve patient outcomes by driven asbestos research effort studying injecting immunotherapy directly into the tumor. the site and its impact on health.

ABRAMSON CANCER CENTER // EXCEPTIONAL 65 THE GLOBAL FOOTPRINT

IF WE WANTED TO REDUCE WORLDWIDE CANCER

MORTALITY, MORE THAN ANY OTHER INTERVENTION,

WE WOULD BRING WHAT WE CURRENTLY HAVE

AVAILABLE IN THIS COUNTRY TO PEOPLE AROUND THE

WORLD WHO DON’T HAVE ACCESS TO IT.

— Lawrence N. Shulman, MD ACC Deputy Director for Clinical Services, Director of the Center for Global Cancer Medicine and Professor of Medicine

046604 Travels to Tanzania Nurses are the front line, interacting with patients every day. Penn’s OncoLink team was presenting at an international conference when nurses from a small country in Africa 40 James Metz, MD COMPLETED Henry K. Pancoast Professor; approached them for help. Their request was simple — they wanted to learn how to take Chair of Radiation Oncology better care of their patients with cancer. 18 Tanzania — on the eastern, central coast — is known primarily for Mount Kilamanjaro and ENROLLED the Serengeti desert. It is one of the poorest countries in the world. The Ocean Road Cancer Institute is the only cancer hospital in Tanzania. Nurses provide most of the care. Many have no special training in oncology. Medical resources are scarce, and it is not unusual to find two GENERAL ONCOLOGY to three people to one hospital bed. COURSE

The dedicated nurses of the Ocean Road began a conversation that has resulted in a model educational program that is changing cancer care in Tanzania. Led by James M. Metz, MD, Henry K. Pancoast Professor and Chair of Radiation Oncology, and Maggie Hampshire, RN, OCN, Director of Strategic Partnerships-OncoLink, Penn physicians and nurses developed a 24 customized curriculum to cover general topics in oncology and specialized training in radiation COMPLETED therapy. The OncoLink team installed computers and developed CD-based and print course materials. More than 60 nurses have completed at least one of the program’s courses. 16 ENROLLED One participant says, “Almost all topics were relevant to my practice, I can say 99%. The program was relevant because now I can see changes, knowing much (more) radiation oncology than before. I have a lot of knowledge and skills in radiation oncology, and RADIATION THERAPY I feel proud.” COURSE The program has expanded to help enhance radiation therapy services. ACC radiation physicists provide technical assistance to their Tanzanian colleagues, helping them improve accuracy and image quality.

Dr. Metz appreciates the dedication of the OncoLink team and others in his department to this work: “This isn’t for the meek. These are big challenges. You have to have the drive and passion to really make it happen. It’s a lot of work, and you can get frustrated quickly. You have to be committed for the long haul.”

ABRAMSON CANCER CENTER // EXCEPTIONAL 67 Botswana and Beyond Abramson Cancer Center physicians travel to Dr. Shulman leads efforts to build stronger Rwanda, Botswana and Haiti. “We’re flexible. cancer care delivery system infrastructure, We learn as we go, and we’ve been able to as well as update recordkeeping in the improve care and show that outcomes for our Botswana clinic so that detailed records of all patients are improving with time,” notes Dr. patients are collected and maintained, patient Shulman. He cites Wilms tumor as an example. outcomes can be tracked and care improved This pediatric tumor is rare in the U.S. but with time. This kind of data infrastructure has common, and until recently not curable, in proven very useful in Rwanda. Rwanda. Dr. Shulman and his team have Many Penn Medicine residents do a rotation introduced new treatments, resulting in a cure in Botswana. “We really consider it part rate of 55%. They continue to make progress, of their training in becoming a doctor to aiming for the 80% U.S. rate. understand what it is like to be sick in these Penn Medicine’s established relationship with places and for us to try to provide care there,” Botswana, which dates back 15 years, now says Dr. Shulman. incorporates a cancer component, including Exchange goes both ways. Sandra Urusaro is new cervical cancer and head and neck cancer a Penn undergraduate nursing student who programs. A Penn radiation oncologist, Surbhi hopes to return to be a nurse at the cancer Grover, MD, Assistant Professor of Radiation center in Rwanda. Oncology, is on site, treating patients and improving medical care and standards on a daily basis.

68

I SEE MYSELF GOING BACK

HOME AND DOING SOMETHING

I LOVE. THIS EDUCATION IS AN

OPPORTUNITY AND A HOPE

FOR THE FUTURE FOR ME AND

MY COUNTRY.

— Sandra Urusaro Penn School of Nursing, Class of 2019

Penn freshman Sandra Urusaro came to the U.S. from Rwanda to study nursing. Her passion for medicine began as a high school student volunteer at Rwandan hospitals. Sandra is interested in global health and exploring ways to translate what she is learning here in an environment with fewer resources.

Sandra is pictured here with her host family, Ralph W. Mueller, CEO, University of Pennsylvania Health System, and Elizabeth Johnston, Executive Director, Clinical Practices of the University of Pennsylvania.

ABRAMSON CANCER CENTER // EXCEPTIONAL 69 Rosato Family: Generations of Giving Back 70 IMPACT

im • pact | ‘im,pakt |

The force exerted by a new idea, concept, technology or ideology. Influence. Effect.

The power of philanthropy to transform cancer research is immeasurable. We are grateful to have such broad-reaching and passionate support.

71

BEYOND THE REWARDS OF GIVING

BACK, THE SARAH MARIE ROSATO

GOLF INVITATIONAL HAS HELPED US

HEAL FROM OUR LOSS BY KEEPING

US CONNECTED TO SARAH. EVEN

AS OUR FAMILY CONTINUES TO

GROW, THE NEW GENERATIONS HAVE POWER OF THE OPPORTUNITY TO BE PART OF SARAH'S LEGACY, EVEN THOUGH SHE

PHILANTHROPY WAS TAKEN FROM US SO YOUNG.

Every day, the Abramson Cancer Center takes collaborative — Geraldine Rosato Partner in Hope strides towards advancing cancer research and care. Our achievements in guiding our patients through their entire cancer care journey, from prevention and detection to treatment and survivorship, would not be possible without the tremendous support of our philanthropic community.

0472727204 A Family Gives Back to Move Forward The Rosato Family, whose Penn roots go back four generations, are among the most loved and well-respected members of the University of Pennsylvania community. But it is their legacy as Abramson Cancer Center philanthropists that will live on for generations.

A beloved surgeon and educator, Dr. Ernest Rosato, M’62, INT’66 (PAR 85, PAR 87, PAR 88, PAR 92, PAR 95) trained a generation of students to be compassionate surgeons. However, his children were the greatest beneficiaries of his humanistic teachings. From him, they learned to be compassionate and thoughtful stewards of humankind.

Known as "the master surgeon of last resort," Dr. Rosato gave countless cancer patients another chance at life. But there was one patient he couldn’t save—his daughter Sarah Marie, who, at twenty-two, lost her courageous battle with sarcoma. I AM A THREE-TIME CANCER SURVIVOR Sarah exuded a bright light of encouragement and fearlessness in life. In her memory, the Rosato family established the Sarah Marie Rosato Golf Invitational to benefit the Abramson Cancer Center’s Survivorship AND CANNOT IMAGINE GETTING Program, specifically young adult survivor initiatives.

By helping survivors gain the tools they need to flourish beyond cancer, the Rosatos honor the future that Sarah THROUGH THESE LIFE-ALTERING didn’t have, and the supportive spirit that inspires cancer survivors to become the people they want to be. EVENTS WITHOUT THE CONSISTENT “We wanted the best care for Sarah and got it at the Abramson Cancer Center. Our golf tournament is a lovely way for us to come together and remember our sparkling, beautiful girl while helping young people recovering ADVOCACY AND HELP OF THE from cancer navigate the new life that is in front of them—as survivors,” says Sarah’s mother, Geraldine Rosato. CANCER SURVIVORSHIP PROGRAM. Now entering its thirteenth year, the Sarah Marie Rosato Golf Invitational has grown considerably over the years through the hard work of the Rosato family and their large community of friends. WORDS CANNOT EXPRESS HOW TRULY The Rosatos are doing more than perpetually honoring Sarah’s courage and Dr. Rosato’s humanistic teaching. GRATEFUL I AM. As philanthropic partners, they help make it possible for the Abramson Cancer Center to provide the most advanced research and care while raising awareness of cancer’s long-term effect on patients’ health — giving — Anne Macey hope to individuals and families for generations to come. Cancer Survivor

ABRAMSON CANCER CENTER // EXCEPTIONAL 73

WE WANTED TO GIVE

EVERYBODY THE CHANCE

TO HAVE THE KIND OF

CARE THAT I RECEIVED. OUR

HOPE IS THAT CANCER

WILL BE ERADICATED — IF

NOT IN MY LIFETIME, IN THE

LIFETIME OF MY CHILDREN AND GRANDCHILDREN. THE POWER OF A NAME

A gift transforms. In 1997, Madlyn and Leonard Abramson bolstered cancer research and care at Penn with a $100 million gift to the University of Pennsylvania Cancer Center. Now over $140 million, their extraordinary investment recognized past accomplishments and secured the future of the newly renamed Abramson Cancer Center as a worldwide leader in the field. — Madlyn & Leonard Abramson Founding Donors, The Abramson family’s generosity incubated many of the accomplishments described in this report and brings Abramson Cancer Center new meaning to the word exceptional.

74 "We’re talking about prevention and early detection. I’m convinced we can get answers and come up with game-

changing treatments and get them to people who need Vice President Joe Biden (r) and Chi V. Dang, MD, PhD (l) at the them. We have an opportunity to fundamentally change launch of the Cancer Moonshot Initiative at Penn Medicine’s Abramson Cancer PHILANTHROPY HAS CATALYZED the trajectory." — Vice President Joe Biden Center, January 15, 2016

MANY INNOVATIONS IN CANCER IN OUR TIME. NOW WITH THE THE TIME MOONSHOT INITIATIVE FUNDING,

ADDITIONAL SUPPORT FROM IS NOW

PHILANTHROPY AND OUR Vice President Biden is shooting for the moon, and the cancer research community is ready to get there. Unlike past “wars COLLABORATIVE CULTURE, WE on cancer,” the "Moonshot Initiative" comes at a time when researchers are truly at the brink of discovery. Spearheaded by ARE WELL POSITIONED TO MAKE the Vice President’s impassioned leadership, the initiative will generate additional public and private funding to stimulate new MANY MORE TRANSFORMATIONAL research and realize the full potential of recent breakthroughs. In an article* highlighting the new initiative, Douglas R. Lowy, MD, DISCOVERIES AT A FASTER PACE Acting Director of the National Cancer Institute, and Francis S. Collins, MD, PhD, Director of the National Institutes of Health, THAN EVER BEFORE. wrote, “One aim of this new initiative is certain: to inspire a new generation of American visionaries to defy the boundaries of current knowledge about cancer.”

— Chi V. Dang, MD, PhD Director, Abramson Cancer Center and *Aiming High — Changing the Trajectory for Cancer. New England Journal John H. Glick, MD, Director’s Professor of Medicine, April 4, 2016. DOI: 10.1056/NEJMp1600894.

ABRAMSON CANCER CENTER // EXCEPTIONAL 75

FOR ALL OUR LIVES, CANCER HAS

STOOD AS THE SUPREME CHALLENGE

FOR SCIENCE AND MEDICINE, SO

DAUNTING A CHALLENGE THAT

WE DARED NOT HOPE IT COULD

BE CONQUERED. YET, HERE WE

ARE, ON THE THRESHOLD OF THAT

VICTORY, AND IT’S HAPPENING AT

THE ABRAMSON CANCER CENTER.

— Richard W. Vague Chair, ACC Director’s Leadership Council; Partner In Hope

04760476 CHAIR ABRAMSON CANCER CENTER Richard W. Vague DIRECTOR’S LEADERSHIP HONORARY CHAIR COUNCIL Madlyn K. Abramson

MEMBERS Lori Alf Stephen A. Cozen Carole Haas Gravagno Donna-Lee Lista Margarita Rooke Daniel Stern Paul C. Astor Stephen Cuthbert Mindy Gray Scott Lustgarten Gerard Michael Rosato Jennifer Stern Rose Astor Ronald R. Donatucci Duncan Hennes Suzi Lustgarten Rafael Rosato Stephen Stonberg Sharyn Berman Lisa Dychala Barbara Herzlich Frances M. Maguire Lynn G. Roseman Carol Summers Gary Blumenthal David Feldman David Alan Jacobs Patrick McNichol Jerry S. Rosenbloom Robert Summers Janice Blumenthal Bonnie Fox Robin Jacobs Alice Meehan Noreen Roth Jackie Topaz Jonathan Brassington Nancy Astor Fox Esther Kaplin Debra Miller Peter Thomas Roth Marc Topaz Linda Brassington Robert Fox Marc Kaplin George Miller Ken Schatz Deborah Feith Tye Andrew Brozman Jerry Francesco Kim Karnell Leslie Anne Miller Loretta Schatz Inez Wade Richard G. Campbell Lucille Francesco Daniel J. Keating III Stacey Mobley Barbara Schiffrin John B. Wade III John Castleman Marilyn Frank Sarah Keating Margaret Nolen Richard Schiffrin Geoffrey K. Watson Edward F. Chacker Mark Frankel David Kessler Louis Pellegrini Gregory Segall Nancy Wolfson Sheila Chacker Judith M. Glick Rhonda Kessler Stacey Pellegrini Rebecca Segall Joshua Wolson Andrew Cohen David I. Goldstein Ron Kresge Shari Potter Benjamin Shein Cheryl A. Colleluori Jerome S. Goodman Ellen Berman Lee Julius B. Rauch III Debbie Stamm Sandra Cozen Sara Gowing Jeffrey Levitt Andrew K. Rooke Sr. Rick Stamm

EMERITUS MEMBERS Steve Atlass Betsy Z. Cohen Elizabeth Gemmill Felicia Lemonick Ruth Nathanson Richard A. Sprague Lynda Barness Rena Rowan Damone Christopher T. Grundner Mariann T. MacDonald Richard Prezelski Mary Anne M. Stetzer Eileen Brode Vic Damone Andrew Kahn Robert MacDonald Sean Rooney William Sweidel Ellen Caplan Sylvia DiBona Peggy Kahn James Matthews Lyn Ross Barbara Sylk Ronald Caplan Donna Cooper Feinberg Helene Kendall Karen Matthews Ann Sorgenti Leonard Sylk Donald S. Cohan Albert J. Feldman James Kravitz Bennett Nathanson Harold Sorgenti Andrew Wilson

ABRAMSON CANCER CENTER // EXCEPTIONAL 77

MY RESEARCH IS ALL DRIVEN BY OUR

YOUNG FRIENDS PATIENTS' NEEDS, BUT IT’S ONLY

of the Abramson Cancer Center THROUGH PHILANTHROPY AND

Ending Cancer with this Generation AWARDS LIKE THESE, THAT WE’RE ABLE Young Friends is dedicated to advocating on behalf of the Abramson Cancer Center and raising awareness of the importance of philanthropic TO MOVE OUR NOVEL AND UNFUNDED support to fuel cancer research and care initiatives. Young Friends IDEAS INTO BETTER TREATMENTS supports the work of young investigators and clinical fellows whose promising ideas often go unrealized due to lack in funding. FOR OUR PATIENTS.

Co-Chairs: Robert D. Blumenthal Daniel Stern — Ronac Mamtani, MD, MSCE Randi Edelman Jennifer Urdang Stern Assistant Professor of Medicine Jonathan Feinberg Joshua Wolson David I. Goldstein

Congratulations to the recent Young Friends awardees: 2016 | Ronac Mamtani, MD, MSCE 2015 | Erin Aakus, MD, and Mark O'Hara, MD As a financial analyst working at the World Trade Center on September 11th, For more information, visit Dr. Mamtani was inspired to change PennMedicine.org/Abramson/YoungFriends career paths in order to help ease the Facebook.com/ACCYoungFriends burden of cancer for patients and families.

78 ENDOWED PROFESSORSHIPS Endowed professorships are among the highest honors a faculty member can achieve. They are vital to the Abramson Cancer Center’s mission to stay at the forefront of cancer research and care by attracting and supporting extraordinary minds and allowing them to explore new avenues of discovery, treatment and cure.

John H. Glick, MD David B. Roth, MD, PhD Caryn Lerman, PhD Madlyn and Leonard Abramson Professor of Clinical Oncology Simon Flexner Professor of Pathology John H. Glick, MD, Professor of Cancer Research Funded by: Madlyn and Leonard Abramson and Laboratory Medicine Funded by*: The Barness Family; Trina and Don Cohan; Honoring the legacy of Dr. Simon Flexner Connie and David Girard-diCarlo; Donna and Barry Kristy L. Weber, MD Feinberg; Penny Grossman Fox and Robert A. Fox; Joseph Abramson Family Professor in Sarcoma Care Excellence Alan J. Wein, MD, PhD (HON) A. Frick; Daniel J. Hilferty; Independence Blue Cross; Funded by: Madlyn and Leonard Abramson Founders Professor in Urology Kenneth R. Jensen; Sarah and Daniel J. Keating III; Jill Funded by*: C.R. Bard, Inc. and John H. Weiland; Leslie Ann and Alan Miller; Martha and Peter Morse; Lyn and the late Jeffrey A. Drebin, MD, PhD, FACS Miller and Richard B. Worley; Iliana and Benjamin Strauss; George Ross; Marcia and Ronald Rubin; Richard A. Sprague; John Rhea Barton Professor in Surgery Jeanette Lerman and Joseph Neubauer; Debra and I. Michael Joanne and the late Raymond Welsh; Allen F. Wise and Honoring the legacy of Dr. John Rhea Barton Coslov; Penny and Robert A. Fox; Linda and Joel Appel; H.F. the late Hanna Wise Lenfest; Michael B. Mann; Diane and Arthur G. Raynes Susan M. Domchek, MD Ursina R. Teitelbaum, MD Basser Professor in Oncology David J. Vaughn, MD Deenie Greitzer and Daniel G. Haller Gastrointestinal Medical Funded by: Mindy and Jon Gray Genitourinary Medical Oncology Professor Oncology Professor Funded by*: Allison and Richard Prezelski; Funded by: Martin Greitzer & Family Michelle Alonso-Basanta, MD, PhD Ruth and Bennett Nathanson Helene Blum Assistant Professor Warren S. Pear, MD, PhD Funded by: Elaine and the late Melvin Merians Chi V. Dang, MD, PhD Gaylord P. and Mary Louise Harnwell Professor John H. Glick, MD, Abramson Cancer Center Honoring the legacy of Dr. Gaylord P. Harnwell Mark I. Greene, MD, PhD, FRCP Director’s Professor John W. Eckman Professor in Medical Science Funded by*: The Barness Family; Trina and Don Cohan; John Hansen-Flaschen Jr., MD Funded by: Rorer Group, Inc. Connie and David Girard-diCarlo; Donna and Barry Feinberg; Paul F. Harron Jr., Family Professor Penny Grossman Fox and Robert A. Fox; Joseph A. Frick; Funded by: James J. Bruder Jr.; Margaret Anne Bruder Douglas L. Fraker, MD Daniel J. Hilferty; Independence Blue Cross; Kenneth R. Nolen; Edward P. Lavin; Jennifer Bruder Lavin; John Imbesi; Jonathan Evans Rhoads Professor Jensen; Sarah and Daniel J. Keating III; Jill and Alan Miller; Patricia H. Imbesi Honoring the legacy of Dr. Jonathan E. Rhoads Martha and Peter Morse; Lyn and the late George Ross; Marcia and Ronald Rubin; Richard A. Sprague; Joanne and Joseph R. Carver, MD the late Raymond Welsh; Allen F. Wise and the late Bernard Fishman Professor Hanna Wise Funded by: Mark and Jill Fishman; Annabelle Fishman

ABRAMSON CANCER CENTER // EXCEPTIONAL 79 ENDOWED PROFESSORSHIPS (CONTINUED)

Appointment in Process Bruce L. Levine, PhD K. Rajender (Raj) Reddy, MD Emilie and Roland T. de Hellebranth Professor in Surgery Barbara and Edward Netter Professor in Cancer Gene Therapy Ruimy Family President's Distinguished Professor Funded by: Emilie de Hellebranth Funded by: Barbara Netter Funded by: Ely Michel & Karen Ruimy

David L. Porter, MD Kojo S.J. Elenitoba-Johnson, MD E. John Wherry, PhD Jodi Fisher Horowitz Professor in Leukemia Care Excellence Peter C. Nowell, MD, Professor Richard and Barbara Schiffrin President's Funded by: Anne and Jerome Fisher Funded by: Leslie Anne Miller and Richard Worley Distinguished Professor Funded by: Richard and Barbara Schiffrin Eli Glatstein, MD James L. Metz, MD Morton M. Kligerman, MD, Professor in Radiation Oncology Henry K. Pancoast Professor of Appointment in Process Funded by: Estate of Irma Howard Radiation Oncology J. Samuel Staub, MD, Professor Honoring the legacy of Dr. Henry Pancoast Funded by: Estate of J. Samuel Staub Stephen J. Schuster, MD Robert and Margarita Louis-Dreyfus Professor in Chronic Ronny Drapkin, MD, PhD Bert W. O’Malley Jr., MD Lymphocytic Leukemia and Lymphoma Clinical Care Franklin L. Payne Professorship Gabriel Tucker Professor Funded by: Margarita Louis-Dreyfus Funded by: Anonymous Mitchell D. Schnall, MD, PhD, FACR Kevin R. Fox, MD Eugene Pendergrass Professor of Radiology Carl H. June, MD Mariann T. and Robert J. MacDonald Professor Honoring the legacy of Dr. Eugene Pendergrass Richard W. Vague Professor in Immunotherapy in Breast Cancer Care Excellence Funded by: Richard W. Vague Funded by: Mariann T. and Robert J. MacDonald Appointment in Process Rhoads-Harrington Professor Gary Wu, MD Steven M. Albelda, MD Funded by: Dolores Harrington; Mark S. Harrington; Ferdinand G. Weisbrod Professor in Gastroenterology William Maul Measey Professor of Medicine Scott L. Harrington; Jonathan E. Rhoads, MD Funded by: Ferdinand G. Weisbrod, MD Funded by: Benjamin and Mary Siddons Measey Foundation Lynn M. Schuchter, MD Michael L. Kochman, MD Mark A. Morgan, MD C. Willard Robinson Professor of Hematology/Oncology Wilmott Family Professor in GI Oncology John J. Mikuta, MD, Professor in Funded by: Ellen Robinson Leopold Funded by: Timothy J. Wilmott and Nancy Barna, MD Gynecologic Oncology Funded by: Ruby W. Bradway Jon Morris, MD Robert H. Vonderheide, MD, DPhil Ernest F. Rosato-William Maul Measey Professor Hanna Wise Professor in Cancer Research Anil K. Rustgi, MD in Surgical Education Funded by: Allen F. Wise T. Grier Miller Professor Funded by*: Lea and William Scanlan; Janet and Eli Caplan; Funded by: Estate of T. Grier Miller Robin and Gary Lassin; Benjamin and Mary Siddons Tzipora Sarah Karin Eisinger, PhD Measey Foundation Ann B. Young Assistant Professor in Cancer Research Angela M. DeMichele, MD, MSCE Funded by: Ann B. Young Family Jill and Alan Miller Associate Professor Edward A. Stadtmauer, MD in Breast Cancer Excellence Roseman, Tarte, Harrow, and Shaffer Families President’s *Listing inclusive of top donors only. Funded by*: Jill and Alan Miller; Courtney and Steven Kapp Distinguished Professorship Funded by: Lynne Goodman Roseman, Karen Goodman Tarte, Amy Goodman Harrow, and Sheri Shaffer Goodman

80 OVER THE YEARS,

PHILANTHROPY HAS BECOME A

MAIN CATALYST FOR INNOVATION

IN CANCER RESEARCH AND PATIENT

CARE. OUR GRATEFUL PATIENTS

AND FRIENDS HAVE TRULY BECOME

ACTIVE PARTICIPANTS IN TAKING

CANCER CARE TO THE NEXT LEVEL.

THROUGH THEIR GENEROSITY,

HOPE IS BROUGHT TO ALL PEOPLE

SERVED BY THE ABRAMSON

CANCER CENTER.

— John H. Glick, MD Vice President, University of Pennsylvania Health System; Associate Dean for Resource Development, Perelman School of Medicine; Former Director, Abramson Cancer Center; President, Abramson Family Cancer Research Institute; Madlyn and Leonard Abramson Professor of Clinical Oncology

ABRAMSON CANCER CENTER // EXCEPTIONAL 81 INSPIRING HOPE: 2015 Event Highlights

This fall we celebrated two star-studded events that raised nearly $12 million and brought together thousands of people to increase awareness of cancer programs at Penn’s Abramson Cancer Center. Spanning Philadelphia and New York, the evenings boasted musical and comedic performances that wowed attendees and brought a healthy dose of levity and laughter to the gatherings. Between acts, former patients and family members shared inspiring stories of hope.

82

MY PARENTS MADLYN AND LEONARD ABRAMSON’S VISION 20 YEARS

AGO WAS TO HELP BUILD A CANCER CENTER WHERE EVERYONE COULD

BENEFIT FROM THE MOST ADVANCED CANCER RESEARCH — A PLACE

WHERE PEOPLE WERE CARED FOR WITH HUMANITY AND COMPASSION,

AND TREATED LIKE AN IMPORTANT MEMBER OF THE FAMILY. I AM SO

PROUD THAT THEIR VISION HAS BECOME A REALITY.

— Nancy Wolfson (pictured with generations of the Abramson Family) Co-Chair, Philly Fights Cancer; Member, Abramson Cancer Center Director's Leadership Council

ABRAMSON CANCER CENTER // EXCEPTIONAL 83 PHILLY FIGHTS CANCER On October 10, 2015, more than 1,000 people gathered for Philly Fights Cancer, the Abramson Cancer Center’s inaugural annual fundraising gala — raising $3.5 million for translational research and clinical trials.

Philly Fights Cancer created a surge of new fundraising energy and excitement for the Abramson Cancer Center. The unrestricted funds raised by this event will help advance promising cancer research, supporting the efforts of the scientists, doctors, nurses and patients on the frontlines of the fight against cancer. The celebration captured the resiliency and strength of so many loved ones who have battled or are still battling cancer, and reminded friends that the Abramson Cancer Center is the destination for exceptional cancer care in our region, throughout the nation and across the globe.

Thank you to Madlyn and Leonard Abramson, Nancy Wolfson, Richard Vague and the Philly Fights Cancer Committee for their leadership and dedication to transforming research ideas into treatments, and taking cancer down for the count.

Visit PennMedicine.org/Abramson/PhillyFightsCancer to see event photos, videos and a list of our other generous partners.

Emily Whitehead (l) and Lori Alf (r), both CAR T-cell immunotherapy patients, found their last chance at hope at the Abramson Cancer Center through innovative clinical trials.

84

TONIGHT WE EMBARK ON PROVING

BASSER JEAN BASH THAT HEREDITY IS NOT DESTINY. On November 10, 2015, more than 1,000 people celebrated in New York City to unzip their genes and raise over $8 million in support of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania. LET’S BRING NEW MEANING TO THE The denim-themed evening brought together many of New York’s leaders in finance, fashion and media, including songwriter Kara Dioguardi and Good Morning America’s Robin Roberts, who emceed the event. Guests heard stories WORD ‘UNIMAGINABLE’ AND IMAGINE of hope and inspiration and rocked out to Freestyle Love Supreme and American Authors. They also saw the launch A WORLD FREE OF HEREDITARY of exclusive rag & bone Basser jeans that boast the Basser Center’s distinct logo — with 7% of the sales to benefit research at the Basser Center for BRCA. CANCERS. Thank you to Mindy and Jon Gray, and the dedicated Gene Pool Committee and all of the generous sponsors whose powerful support will help quicken the pace of life-saving medical discoveries to treat and ultimately prevent BRCA- related cancers. — Mindy Gray (pictured with husband, Jon Gray) Visit Basser.org/JeanBash to see photos, videos and a list of our other generous partners. Founding Donors, Basser Center for BRCA

ABRAMSON CANCER CENTER // EXCEPTIONAL 85 048604 I'M DEEPLY HONORED TO HAVE DR. JUNE AND THE UNIVERSITY OF PENNSYLVANIA AS ESSENTIAL PARTNERS IN THE PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY AND I BELIEVE THAT TOGETHER WE WILL MAKE NEW DISCOVERIES THAT HAVE THE POTENTIAL TO CURE CANCER IN ALL TYPES AND STAGES OF THE DISEASE.

— Sean Parker President of The Parker Foundation GALA CELEBRATES NEW COLLABORATION Silicon Valley philanthropist and entrepreneur Sean Parker brought scientists and friends together in April 2016 for the inaugural gathering of the Parker Institute for Cancer Immunotherapy. Early in the day, scientists from Penn and the five other participating institutions discussed their plans for the unique collaboration at an event moderated by Katie Couric.

An evening gala at Parker’s home included performances from John Legend, the Red Hot Chili Peppers and Lady Gaga. The gala highlighted the work of this country’s leading immunologists, and patients including Emily Whitehead, the first pediatric patient to participate in a clinical trial of the Penn-developed personalized cellular therapy, also known as CAR T-cell therapy. Nearly four years after her treatment at the Children’s Hospital of Philadelphia, she remains in remission.

“I’m not just optimistic — I’m convinced that the collaboration will speed new treatments to help more patients,” Penn Parker Institute director Carl June, MD, told Getty Images as he walked the red carpet into the gala. “It’s an amazing time to celebrate. We have the tools, and we have the team of people working together.”

Read more about Dr. June’s work and other immunotherapy research underway at the Abramson Cancer Center on page 24 of this report.

ABRAMSON CANCER CENTER // EXCEPTIONAL 87 HONOR ROLL Gifts listed are from July 1, 2013 through June 30, 2015, unless otherwise noted, and appear at the level they were given in a single fiscal year. If we have omitted or misstated an acknowledgement, please let us know by contacting the Abramson Cancer Center Development Office at215.898.0578 or [email protected].

DIRECTOR'S LEADERSHIP SOCIETY $100,000 & ABOVE Leonard & Madlyn Abramson Jonathan H. Feinberg, Esq. Marc Alexander Loev, MD & Toni Hawley, MD Mary & Edward J. Prostic Family Foundation Stacy E. Feinberg Mariann & Robert MacDonald Julius B. Rauch III A Love for Life Anne & the late Jerome Fisher James J. Maguire Sara & Eric Resnick AB Charitable FD 92 Annabelle Fishman Samuel P. Mandell Foundation Friends of the Ride to Conquer Cancer Hallee & David Adelman Jill & Mark A. Fishman Rachel K. Mann Joseph C. Romano Herbert E. Adelman Penny & Robert A. Fox Neiman Marcus Kelly Rooney Foundation Lori & Christopher Alf Ellen & Raymond Goldberg Martinson Family Foundation Jay A. Roseman and Lynn Goodman Roseman Anonymous Jerome & Maxine Goodman Messner Foundation, Inc. Jerry S. Rosenbloom, PhD Arete Foundation Sara & James Gowing Jill & Alan B. Miller Marcia & Ronald Rubin Sandra Baldino Mindy & Jon Gray Debra & George K. Miller, Jr. Karen & Ely Michel Ruimy Lynne & Leonard Barrack Joel K. Greenberg & Marcy Gringlas, PhD Tara Miller Melanoma Foundation Say Yes To Education, Inc. Barrack Foundation Otto Haas Charitable Trust Leslie Anne Miller, Esq. & Mr. Richard Worley Sheri Goodman Schaffer Marc H. Berman & David C. Berman Mark H. & Blanche M. Harrington Foundation Stacey J. Mobley, Esq. & Joan T. Mobley, MD Barbara & Richard Schiffrin Sharyn Berman Jeffrey K. Harrow & Amy Goodman Harrow Martha & Peter Morse Karl Schlecht Foundation Be the Difference Foundation I. Chera & Sons Foundation, Inc. Ruth & Bennett Nathanson Rebecca & Gregory Segall The Bethesda Foundation Independence Blue Cross Barbara S. Netter The Seraph Foundation Theodora B. Betz Foundation Robin & David Alan Jacobs Cristina Nicolo Margaret Grace Sherman David Bonderman Jewish Communal Fund of New York Nancy Nicolo Marcy & Robert Shoemaker Linda & Jonathan A. Brassington Stella S. Jones, PhD Palmira & James Nicolo Lydia & Doug Shorenstein James D. Brock, PhD Barbara McNeil Jordan Judith Z. Nissenbaum & Andrew E. Zolot Steve Sidewater & Judy Munroe The Honorable Tina Brozman Foundation Robert J. Kahn Foundation & Kenneth C. Zolot Catherine & Sam Sidewater Peter L. Buttenwieser & Ms. Terry Marek Courtney & Steven Kapp Yetta Deitch Novotny Charitable Trust The Sidewater Family Foundation Julius H. Caplan Charity Foundation Michele & Kevah Konner Darcy & Andrew Nussbaum Richard A. Sprague, Esq. Darco Capital, LP James & Barbara Kravitz Janet W. O'Connor Sprague & Sprague The Derfner Foundation Dr. Barbara Kravitz Esther B. O'Keeffe Foundation Debbie & Rick Stamm R & B, Inc. H & H Kravitz Charitable Trust Sean N. Parker Foundation Louis & Bessie Stein Christine Edmonds Allen Kronstadt Bhavna & Mukesh Patel Jane & Michael Stolper Elpis Foundation Laffey-McHugh Foundation Pennies in Action Carol & Norman Stone Fashion Footwear Charitable Foundation, Inc. Julie & Robert Levine Shari & Len Potter Richard L. Storch Judy & Marc Felgoise Susan & Jeffrey Levitt Allison & Richard Prezelski Structure Tone, Inc. Donna & Barry Feinberg

88 Scott Tarte & Karen Goodman Tarte Jackie & Marc Topaz Wealth Strategy Holding Limited Withington Foundation, Inc. The Topaz Family Charitable Fund United Way of Greater Toronto George & Lydia Weiss Nancy & Richard Wolfson Dr. John M. Templeton Jr. Richard W. Vague Timothy J. Wilmott & Nancy Barna, MD Joan & John Thalheimer Elizabeth & Geoff Watson Alan Wise

ABRAMSON CANCER CENTER DIRECTOR'S SOCIETY $10,000 – $99,999 William & Donna Acquavella Deanna & Jordan Berman Wendy & Ian F. Crossland, Esq. EventQuip Acquavella Family Foundation Steven & Ilene Berman Family Foundation CSL Behring Biotherapies for Life Ewing Family Foundation Philip & Ethel Adelman Alfred Berry Cuthbert Cancer Foundation FasterCures Aetna Foundation, Inc. Joseph Bilinski Charitable Trust Kimberly & Louis J. D'Ambrosio Albert J. Feldman, Esq. Albert Brothers, Inc. Tzedakah Gift Fund Janice & Gary Blumenthal Mary & Chi V. Dang David J. Feldman, Esq. & Marilyn Frank Vincent & Veronica Anderson Boyd's Dara Defense Fieldstone 1793 Foundation Anonymous Breakthrough Bike Challenge The Dayspring Foundation Janet L. Finan Helene & Allen Apter Foundation Peter Bresnan & Annette Canby Matthew J. Derham Firstrust Bank Jeanne & Ed Arnold Elizabeth Brodie Department of Medicine First Hospital Foundation Mary & Richard A. Ashley Sidney & Sandy Brown Department of Neurosurgery Suzanne & Frederick C. Fletcher II Rose & Paul C. Astor Brulee Catering Department of Obstetrics & Gynecology Florida Fish for Life, Inc. AstraZeneca Pharmaceuticals, LP Ellen Bujnowski Department of Orthopaedic Surgery Dr. Jerry Francesco & Atrin Pharmaceuticals Burnett Family Charitable Fund Department of Pathology Mrs. Lucille Francesco The Auldridge Fund Janet Burros Memorial Foundation Department of Radiation Oncology Claire S. Frankel Michael Avallone Peggy & Joe Carver Department of Radiology Linda Frankel Regina L. Avallone Herbert T. Caskey, MD Department of Surgery Mark A. Frankel, Esq. Bala Golf Club Valerie & Lauriston Castleman Division of Urology Franklin Square Partners Ballinger, Inc. Andrea Cavitolo Foundation Jean & Norman DeSouza Free Will Brewing Co. Lynda Anne Barness Sheila & Edward Chacker G. Fred & Sylvia DiBona Family Foundation Mark Allen Friedman Foundation Nancy S. Barness Cobb Foundation, Inc. The Dietz Family Mr. & Mrs. C. Meade Geisel Jr. Robin Batoff & Fred Robbins Donald S. Cohan, Esq. & Trina Cohan Dietz & Watson, Inc. General Electric Company Bentley Systems, Inc. Marjorie B. Cohen Foundation Mr. & Mrs. John J. Donnelly J. Paul Getty Trust Lee & Ian J. Berg Fund Andrew Cohen Susan & James D. Dunning Jr. Susan & David Getz The Berkman Family Charitable Fund Gillian Moss-Cohen & Robert Cohen Jan Eisner Carol & Gaetano P. Giordano Bryna & Fred Berman Constellation Pharmaceuticals Lois Elkman Deborah & Dennis Glass Dr. Arnold Berman Conwell Corporation Dr. Beverly Willis Emanuel Barry H. Glick Charitable Fund Ellen Berman Lee Cookies Till Tuesday The Epstein Whitman Charitable Fund Rosalie & Harvey Goldberg Joanne & Geoffrey Berman Sandra & Stephen A. Cozen Evantine Design The Goldman Sachs Group, Inc.

ABRAMSON CANCER CENTER // EXCEPTIONAL 89 ABRAMSON CANCER CENTER DIRECTOR'S SOCIETY $10,000 – $99,999 (CONTINUED) Governor's Woods Foundation Mr. Jack L. Karp L. F. Driscoll Company Mr. & Mrs. Jonathan Netzel Elizabeth & George A. Graham Francine & Steven Katz Susan & Paul Lichtman Aharon Netzer, PhD & Shula Netzer Greater Kansas City Community Foundation Sarah & Dan Keating Lincoln Financial Anne Neustadter Amy & Bill Green Keating Development Company LiquidHub Charitable Fund Michael J. Neustadter Pancreatic Cancer Fund Daniel B. Green Rhonda & David Kessler William W. Lockwood Jr. Nikolaus Family Foundation Richard J. Green, Esq. The Kessler Family Karen & Herbert Lotman Foundation Margaret Anne & James Nolen Jane & Barry Haimes Dr. Yasin N. Khan & Dr. Elizabeth A. Khan Gregg W. Ludlam Maureen & Peter P. Paoli Haimes Family Foundation KieranTimberlake Suzi & Scott Lustgarten Family Foundation Pedal for Pink Tyrone J. Hankin Susan & Leonard M. Klehr Lutron Foundation Peggy Spiegler Melanoma Research Raymond E. Haupt Stephen B. Klein Shirley Mae Run Foundation Headstrong Foundation Sarah & Kevin Kleinschmidt Manko, Gold, Katcher, and Fox Penn Dermatology Oncology Center Kelly D. Heflin Foundation Gary Kohler & Anne Drennan Maple Hill Foundation Pennsylvania Oncology Hematology Associates, PC Herb Gordon Foundation Rachel Kohn Philanthropic Fund Marc David Foundation Perelman School of Medicine in Gastrointestinal Cancers Laura & James S. Korman Rocco & Barbara Martino Foundation Peter Skelton Sarcoma Research Foundation, Inc. Herrin Family Foundation Korman Communities Michael Mascaro Philadelphia Magazine Ethel G. & Walter I. Hofman, MD Thomas D. Kraemer Matrix Group, Inc. Joan M. Piscopo Mr. & Mrs. Larry Horowitz Marcy & Jeffrey Kramp McCausland Keen & Buckman Richard J. Pogach Memorial Foundation Cherifa & Greg Howarth Dr. Ronald R. Kresge & Ms. Joanne Schrenko Mercedes-Benz of Atlantic City The late David & Lorraine Popowich George B. & Barbara C. Howell Fund K-Ten-Kids Foundation Mercedes-Benz of Fort Washington PricewaterhouseCoopers, LLP IMS Health Lamm Family Foundation Mercedes-Benz of West Chester M. Stephen Rasch Incyte Corporation Landenberger Family Foundation Merck & Co., Inc. Raymond F. Reed Mr. & Mrs. M. Roy Jackson Jr. Larry's Legacy — Sunflowers of Hope, Inc. Margaret E. Mikuta Emily & Richard Reiner Anne & Joseph Jacovini, Esq. LCG, Ltd. Fred Miller Rena Rowan Breast Center Robert & Julie Jensen Bryan Mei Li & Leslie Leff John W. Mills Research Foundation of the Jewish Federation of the Lehigh Valley Ellyn Goodman Lehr & Seth Lehr Pamela Minford Charitable Foundation Treatment of Ovarian Cancer JNS Charitable Trust Marguerite & Gerry Lenfest Nancy & James Minnick Linda Richardson Victoria J. Johnson Margaret J. Leonard Mistler Family Foundation Rick's Run Johnson & Johnson Corporation Leslie & Stephen Levick Mr. & Mrs. Keith A. Morgan Cynthia & Joseph F. Riggs Johnson & Johnson Services, Inc. James G. Levin, Esq. & Lisa Tucker Beverly & Mark A. Morgan, MD The William Ellis Robinson Foundation Jonathan Bassman Interior Design, LLC Lori & Raymond M. Levin Kevin Morgan Monette & Fred Robinson JP Mascaro & Sons Charitable Trust Charles & Margaret Levin Family Elizabeth & Stephen W. Morro Peter Thomas & Noreen Roth June & Steve Wolfson Family Foundation Foundation, Inc. Mosi Foundation Danielle & Gerard Rosato Kahn Foundation Diane & Harry Levin Foundation Moving For Melanoma Francie & Rafael Rosato Esther & Marc B. Kaplin Levine Family Foundation, Inc. Julie Mrak Geraldine Rosato Kimberly K. Karnell Michael J. & Patricia Levitt Rosalind Shapiro Neff & Roy S. Neff John T. Rudden Elisa Tractman Lewis

90 Fred Miller & Judy Ruggeri Sky Community Partners, Inc. Teal Ribbon Ovarian Cancer Research Inez & John B. Wade III Run for the Stripes Eunice W. Smith Foundation, Inc. Craig Wallentine & Elaine L. Klein Run/Walk 4 Family & Friends with Cancer Heidi & Scott Smith Ted Driven, LLC Jeffrey M. Waranch Biff Ruttenberg Foundation Karen Smith Ken Templeton Gordon A. B. Watson Saks Fifth Avenue Phyllis & Irving Smith Foundation, Inc. Thyroid Hope, Inc. We Rock for Doc Memorial Fund Michael E. Sand & Ilana Katz-Sand, MD The Garrett B. Smith Foundation Ronald R. Tipps Helene C. Weathers Sangamo Biosciences Inc Dr. Robert C. & Tina Sohn Foundation Betty N. Tornetta & Family Faith & Sol H. Weiss, Esq. Kenneth & Loretta Schatz Foundation Joan & Bernard B. Spain Mrs. H. Lynn Tractman Harriett & Larry Weiss Helen Schneeberg Ann & Murray Spain Foundation Tube Methods Inc Joanne & the late Raymond Welsh Schwab Charitable Fund Judy & Michael Steinhardt Charles E. Tweedy III Charitable Foundation Aileen Whitman James D. Scully Jr. & Marlene Stoczko Jennifer & Daniel B. Stern Deborah Feith Tye & Family Dorinda & Mark Winkelman Segall Family Foundation Stacey & Phillip B. Storm UBS Financial Diane & Howard Wohl Family Foundation Melanie & Lewis S. Sharps, MD Patrick Sullivan United Way of Delaware Greg Wolf Fund, Inc. Nancy & Benjamin Shein Carol & Robert B. Summers United Way of Greater Philadelphia Gail S. Wolson & Southern New Jersey M. David & Mary Alice Sherrill Jane & James Sutow WSFS Bank University of Pennsylvania Health System Salem Shuchman & Barbara Klock Srinivasan Swaminathan, PhD Zeelander Foundation USM, Inc. Simon Tar Holdings, LLC Wachs-Weingarten Charitable Trust Singer Childrens Management Trust

ABRAMSON CANCER CENTER BENEFACTOR $5,000 – $9,999 Geeta Narendra Ahya Bristol-Myers Squibb Company Exelon Corporation Jerome & Flora Heilweil Foundation All Baby & Child Mr. & Mrs. Kenneth A. Caplan Jacob & Anita Farber Philanthropic Fund Hives for Lives Alliance Bernstein, LP The Carefree Foundation Mr. & Mrs. Morton H. Fetterolf III Horowitz Family Foundation Edwina & Daniel F. Amoroso Carmela Terlingo Cancer Fund First American Title Insurance Company Mr. & Mrs. Edward Hueber Randolph J. Angermann Carolina Herrera, Ltd. Anna Fletcher Carol G. & Lawrence A. Huff Ash Family Foundation Checking for Cancer Forman Family Foundation Robert B. Karofsky Edgar Astrove William Black Jr. & Catherine Chew Black Foundation for Breast & Prostate Health Mr. & Mrs. Adam Kauffman Athena Cosmetics, Inc. Margaret B. Ciarciello Nancy A. & Robert D. Fox Mr. & Mrs. William Kramer Mrs. Lois Harshaw Barker Mr. & Mrs. David Clarke Dina F. Ghen Mr. & Mrs. Martin Krimsky Pearl & Philip B. Basser Alma & Sylvan Cohen Philanthropic Fund Dr. & Mrs. John H. Glick Laminar Flow Inc. Mr. & Mrs. Thomas Bedwell Duane Deaner Glazer Family Foundation Jerry Lee Mr. & Mrs. Jonathan Jay Belding The late Mario R. DiBenedetto David I. Goldstein Benjamin D. Lev, MD & the late Dorota Lev Richard S. Bowles III Melissa E. Dietz Barbara R. Gomes Marce & William Leventon Steven L. Boynton Dimitrief Family Charitable Fund Lauri & Tom Gosnell Mr. & Mrs. Michael Levin The Brendan Borek High Tides Kevin Dowd Dianne & Robert Greer LiquidHub, Inc. Memorial Fund, Inc. Lowell H. Dubrow, Esq. Mr. G. Gushner Carol & Horace A. Long Mr. & Mrs. John J. Brighton Eastern Produce Council, Inc. Maryellen Hafele J. Lorber Company

ABRAMSON CANCER CENTER // EXCEPTIONAL 91 Robert A. Lustig, MD Cathy Neuman Rena Rowan Foundation Carol Strickberger Lani & Thomas F. J. MacAniff Irving J. Neuman Johanna W. Schleyer SugarHouse Casino Richard & Jane Manoogian Foundation & Mickey Neuman Philanthropic Fund Elliot D. Schwartz Selma S. Sugarman Marrow-McGuire Family Fund Patricia Neuman Dr. & Mrs. Louis Schwartz Mr. & Mrs. Gregory L. Summe Joy & Peter Martosella Jr. Mr. & Mrs. James J. Oliver Martin D. & Jean Shafiroff Foundation The Susan Fazio Foundation McCandless Family Charitable Fund Joel Ospovat Shirat Ha Yam Fund for Melanoma Research Mr. & Mrs. Edward K. McCullough Arthur Penn Lorna Shuster Susquehanna Foundation Joan McCullough Philadelphia Eagles Football Club David H. Singer Ellen & Frank D. Svitek Thomas R. Meehan Roberta Pichini Dr. Arthur P. Staddon Tioga Foundation Mr. & Mrs. Walter Meranze Lisa B. Popowich & Jonathan B. Stein & Ms. Marcia Robb Staddon William J. Weber Linda & David M. Mintzer Mr. & Mrs. Stuart Lee Potter Stagestep, Inc. Jeffrey Yass & Janie A. Coslett-Yass The Joe Moody Foundation Janet S. Pratowski Mr. & Mrs. David A. Stevens Mr. Paul M. Yeakel & Ms. Lynn H. Yeakel Jonni S. Moore, PhD Leonard P. Punia Mr. & Mrs. Ronald Stevens Mr. Brahm Cramer & Ms. Dana Zucker & Roger Addison Moore, MD Louise & Alan L. Reed Jennifer & George Stone Katherine Morris Thomas Rosato Charitable Foundation Nancy E. Strahle

FACULTY SOCIETY $2,500 – $4,999 Alliance Global Services, LLC Delaware Community Foundation Eli Glatstein, MD Dr. Steven A. Levy American Securities Foundation Donatucci 2015 Committee Good Charity, Inc. Richard S. Linhart Philanthropic Fund Lisa & John Ariano Down Goes Cancer, The Joe Mak Joe Gursky Dr. Robert Linkenheimer A.W.R. Foundation Memorial Foundation Hankin Foundation Dr. & Mrs. Craig H. Lubin Barry Wish Family Foundation, Inc. DPR Construction Heritage Auctions Carol & John Lucey Cristina L. Basser & Stephen R. Basser, Esq. Dubrow, PC Himmelstein Family Foundation Teresa Macauley Christin Laureen Bassett Deborah & Michael Dugan Hunter Roberts Construction Group Joan Mackie Belfor Property Restoration Elena Ariano Memorial IBEW Local Union 98 Manayunk Fools Run Ovarian Cancer Research Fund Laura & David L. Bellet Icicle Brewing Company Mr. & Mrs. James D. Mann Ewing Cole David Brand Dr. Nathaniel Jellinek Barbara S. McKee Excel Communuications Worldwide, Inc. Paul Branum Jewish Community Center in Manhattan Mr. & Ms. Michael Meehan Karen & Samuel J. Farruggio Bartholomew Brazinski Dr. & Mrs. Ian M. Joffe Mr. & Mrs. Jon Mehlman Fields Hi-Rise Construction Company, LLC Helene Byrnes Just Give Michael Sosin & Tedi Siminoswky Fund Bonnie Brandeis Fox Causecast Foundation Robert P. Kagan & Paula J. Sunshine Moorestown Township Board of Education Angela N. Francolino Mr. & Mrs. John A. Chambers KG Foundation Mount Pleasant Fund Kathryn B. & Stephen G. Frank Robert A. Clair Dr. Meredith Klein Kosann Joseph Naggar Stephen Freier Thomas B. Coppage Lafayette Hill Family Dentistry Maris Ogg & Robert C. Smith Gary L. Fuhrman Paul G. Curcillo II, MD & Stephanie A. King, MD Dr. & Mrs. Morton Langsfeld III Partnership for Health Analytic Research Dr. & Mrs. Douglas O. Gause Karen Daroff John Trojanowski, MD, PhD The William Penn Foundation Larry A. Gephart & Virginia M-Y Lee, PhD

92 The Pew Charitable Trusts Arthur Rosenberg Dr. Janice M. Soreth Urquhart Ponzio's Rd, Inc. DBA Metro Diner Salesforce.com Foundation Marjorie Seltzer Stanek, MD Ursa Development Group James Previti Family Foundation Mr. & Mrs. Hyman Sall Mary Anne M. & John J. Stetzer III Vanguard Group Foundation Mrs. Abbe S. Prevor Denise M. Santa Barbara Diana Stripp Jacqueline M. Washburn Quaker Maid Meat, Inc. Sb1 Federal Credit Union Jay T. Sung The late Jacob Wasserman Raymond James & Associates, Inc. Mr. & Mrs. Christopher Schlank Mr. & Mrs. Alfred F. Talbot Brad Weber Razoo Foundation Shelly Electric Co., Inc. Troy W. Tegeler Patricia Whittaker Razrbar Mens Salon The Shelter Foundation, Inc. John C. Tompson Widener University Ree Wynn Foundation The Honorable I. Shimer & G. Shimer, Esq. Daniel Travers Ross J. Roberts Silicon Valley Truist

PATIENT CARE SOCIETY $1,000 – $2,499 1999 Family Foundation Ben & Blanche Weiss Carson Choice, Inc. Mr. & Mrs. James E. Daley Gerald Adams Philip Berber Christine Caserta-Voluck & Arnold Voluck DeLage Laden Financial Services Aetna Life & Casualty, Co. Nancy Beren & Larry Jefferson, MD Esther M. & James H. Cavanaugh, MD Wendy T. & Paul Delaney Mr. & Mrs. Patrick A. Alia Beyond the Pink Moon Cedarbrook Country Club Delaware County Christian School Alpine Development Partners, LLC Carol B. Blank Centurion Benefits, LLC Marie T. Devlin Stephen Altman Mr. & Mrs. Ronald E. Blessing The Chapin School, Ltd. Di Bruno Bros. Daniel Alva, Esq. Bob's Stores Dr. Ching-Lynn Chen Hans O. Dietze American Endowment Foundation S.C. Bodan Mr. & Mrs. Joseph R. Chinnici Mr. Vincent M. Dignazio Mr. & Mrs. Oakley P. Amerman Jr. Boenning & Scattergood Mr. & Mrs. Emile F. Cochet Jr. Dilworth Paxson, LLP Gen Anonymous #712 Mark C. Bokelman Laura A. Cochet Shari Dinaburg & Barry Andrew Aqua Charitable Trust Jill F. & Sheldon M. Bonovitz Cocktails Against Cancer Dinaburg, Esq. Archer & Greiner, PC Michael Bosica D. Walter Cohen, DDS Anthony J. DiOttavio Arlington Professional Firefighters Betty A. Bostwick Lawrence I. Cohen Mr. & Mrs. Paul A. Dix & Paramedics Association Mr. & Mrs. Kevin R. Boyle Darlene Cohn Elizabeth Dobos Susan Dole Armstrong Wendy S. & Morton R. Branzburg Ivy & Stephen Cohn Elizabeth G. & Kevin F. Donohoe Barbara E. Arning Theodore Breckel Mr. & Mrs. Earle A. Compton Dorothy & Frank L. Savage Family Fund Patricia J. Arrington Edie W. Bristol Concentus Wealth Advisors Jay F. Dorsey Avery Foundation Jay Ashley Bromfield Joan & Art Connolly Family Fund Joseph B. Doto Jr., MD Gary L. Azorsky, Esq. Jean & R. Nick Bryan Mr. & Mrs. William L. Conrad Tracy Douthit Mr. & Mrs. Dylan W. Baker Barbara Thomas Butler Consolidated Edison Co. of NY Charlotte Drummond Ballard Spahr, LLP August J. Calderone Elizabeth Ann Coyne Dry Family Charitable Foundation Banfield Family Foundation California Pizza Cozen O'Connor Foundation Stuart Ebby & Judith Ebby, MD Bank of America Corporation Maria & Richard G. Campbell Crebilly Foundation Mr. & Mrs. Marty D. Ellick The Barra Foundation, Inc. Annemarie Candy Crusaders for a Cause, Inc. Ann F. Enders Peter Barsanti Antonio Caram Eva Daicar, PhD Lucia & Richard A. Englander

ABRAMSON CANCER CENTER // EXCEPTIONAL 93 PATIENT CARE SOCIETY $1,000 – $2,499 (CONTINUED) Erin Development Co., Inc. Good Shepherd Home IMX Medical Management Services Cheryl Koons Mr. & Mrs. Steven Erlbaum Dr. Gary Gordon & Interboro Class of 1964 Bernice J. Koplin Michael C. Erlbaum Professor Nancy Bregstein Gordon ISALYS Fund Arnold H. Kramer Erlbaum Family Foundation Jeffrey M. Gordon Jacobs Music Company Barbara Krenzel Erlikh Charitable Lead Annuity Trust Lorraine R. Gordon J. A. Drywall, LLC Barbara M. Kretchmar Bonnie M. Eusner Patricia S. & Milton H. Grannatt III Vera James Shirlyn B. & Donald R. Kurz Elaine B. Feldman Grant's Financial Publishing, Inc. James Oliver Gallery Raymond Kwong Elizabeth Fenner A. Alan Gross Jatmo, Inc. Sharon I. Labow Mr. & Mrs. Bruce W. Ficken Prabodh K. Gupta, MD Jefferies, LLC The Honorable William H. Lamb Carla Suzanne Fisher, MD Amy Gutenplan Jernigan Family Advised Fund & Patricia Lamb Kevin Flynn Ms. Annie L. Guzek Millicent & Leon Jonas Jr. George Landau F.O. Eagles #472, Inc. Janet Haas, MD & John O. Haas Susan & Aravind Joshi, MD Trever W. Landis Memorial Fund Fond Memories Mr. & Mrs. Henry B. Haitz Jr. Lisa Speicher & Carl H. June, MD Ms. Joan Langbord Mr. & Mrs. Charles Forand Alan S. Halperin, Esq. Mary E. June Harriet J. & Ronald P. Lassin Mr. & Mrs. Scott Fortman Sharon M. & Stephen P. Harrington James & Bethel Junge Fund Ellen B. Lee Leonard Frankel Foundation for Leukemia Jane Wagenfeld Harris Susan & Barry F. Kahan Jean B. Lehman Ann K. Frankhouse Jill Werman Harris Henry J. Kaiser Family Foundation The Lehman Foundation Fresh Grocer Mr. & Mrs. Peter J. Hart Melissa Bernhardt Kalish Lenahan & Dempsey, PC Fundamental Administrative Services, LLC Lee Hartner, MD Adam Kaminer Charlotte Levey Lois Gartner Andrew Harwood Noah Kaminer Brad Levie Alexander L. Gellman Peter Hasson Gary D. Kao, MD Carol S. Levin Elizabeth H. Gemmill, Esq. Suzette & Peter C. Hearn David M. Kaplan Robert W. Levis Richard Edward Genter Mr. & Mrs. Brad Eric Heffler Jacqueline & Ronald Kaplan Mr. Gregory Lewis Sumner Gerard Foundation Rosalynn H. & Daniel Heth Bruce E. Kardon Yang Zheng & Dexin Li Nancy & Carl Stanford Gewirz Dr. Clifford Deutschman Leslie Kase Mauri E. Librett & Ms. Christine Hilke Barbara & Richard A. Gillespie Peter R. & Cynthia K. Kellogg Foundation Mary Ann Liebert, Inc. Karen & Peter J. Hoffman Peter F. Gilligan Eileen M. Kelly Bernard M. Liebowitz Holman Automotive Group, Inc. Dr. & Mrs. John Glassburn Steven J. Kempen Lifecare, Inc. Mr. & Mrs. Michael D. Honeywell GlaxoSmithKline Winnie Kho Alexander Lin, MD Mr. & Mrs. George R. Hornig Glenmede Trust Mr. & Mrs. Arthur G. Killian Kevin Lipton Dolores Howell Sam Glickman Mr. & Mrs. Richard Kimball Living Beyond Breast Cancer Lisa Hughes Golden Corral Charitable Fund Adelle S. Kline Patricia Locantore-Ford Willie Mae Hughes Lester A. Goldstein Monica T. & Gerald Knorr Bob Lockyer Doris Huntzinger Richard Goldstein Danielle Kober Carol & Robert Lockyer Farah M. Jimenez & David Hyman The Goldwein Family Fund Eric W. Koelbel Christine A. & Frederick D. Loomis IMS Health Mr. & Mrs. Bruce A. Goodman James D. Kolker, MD & Mrs. Druellen Kolker Cynthia L. & Roger A. Lopata

94 John Love Christian Milton The Great Pocomoke Fair Debra L. Selig Curt Lundgren Kathleen T. Montone, MD Abigail Pogrebin James E. Serley Richard Macaulay Trish Moody Mr. & Mrs. Andrew Pressman Settlement Engine, Inc. M/A Gemini 44 Fund Rita & John P. Moore Price Honda Acura Friends of Josh Shapiro Patrick J. Maher John P. Moran Pzena Investment Management Vivian B. & Harold T. Shapiro, MD Steve Malloy Andrew F. Moses Masood Qamar Bruce Shelly Manhattan Orthopedic Michael Murphy QRP-Voorhees, LP Richard W. Shoulberg & Sports Medicine, PC Joan M. Murray Quagga Accessories, LLC Elizabeth W. Shumadine Marc Summers Productions, Inc. Diane M. & Scott H. Mustin Diane Slavitz Raynes Mr. & Mrs. Arthur H. Siegel Markos 941, Ltd. Usman Nabi Mr. & Mrs. Brendan Reilly Mr. Stephen B. Siegel Martin Dealerships Network for Good Beth & Richard J. Reisboard Simco Logistics Inc., t/a Jack & Jill, DSD Elizabeth & Victor Mather II Newark Toyota World Jacqueline K. Resinger Charles B. Simone II, MD Mary M. & Charles E. Mather III Ida Newman Dana Rhodes Megan Simpson Burke Memorial Foundation Judith & Morris Matsunobu Mary Ruth Newman R. Jane Schwam Interior Design The Sirrus Group Tamera & Joseph Matteo Inspector & Mrs. Laurence D. Nodiff Roberts Communications Service's, Inc. Martin Slagter Mayer Electric Supply North Run Capital, LP Roll Global, LLC Smith Family Fund Clifton M. McClinton Nucar Connection Jeannette & Gary Rosato, MD Nancy V. Snyder A. Donald McCulloch Jr. Nunn Family Charitable Fund Susan & William Rosato Richard H. Snyder Kathryn McDonald Douglas R. Olson Dr. & Mrs. Edwin S. Rosenberg Jean & David Soll Philanthropic Fund James McDonough, PhD Shaun F. O'Malley Dr. Ariella Rosengard Louise A. Sonnenberg, MD McDowell Foundation Emily Orel Mr. & Mrs. Jerold E. Rothkoff Paul W. Sperduto, MD, MPP Lisa D. Kabnick & John McFadden Dean W. O'Toole Dr. Ajit Sachdeva & Dr. Rajeev Sachdeva Stuart J. Spivak Nancy G. McGuire Mr. & Mrs. John F. Palladino Robert Saligman Charitable Foundation Spray-Tek, LLC Dr. & Mrs. James McGuire Gina Passero Salty Stache Productions, LLC Bonnie Goldsborough Stanfield Lauren McKee Mr. & Mrs. Joseph I. Passon Mr. & Mrs. Steven G. Samples Baldasarre Stea, MD, PhD, FASTRO Lillian McKenzie Pat Kelsh Woolf Account Dahlia M. Sataloff, MD & Robert Sataloff, MD Mr. & Mrs. Randall C. Stein Mr. & Mrs. Richard J. McMahon Warren S. Pear, MD, PhD Sherrie R. Savett Family Foundation Mr. & Mrs. Mark E. Stelnik Sandra K. & David McMullin Arlene Pearlstein George Saxon Zelda R. Stern John M. McNamara Kevin & Erica Penn Charitable Foundation Helen Schneeberg Revocable Living Trust Allan Steyer Mr. & Mrs. John F. McNichol Penn Club of New York Miriam A. Schneirov Theresa J. Synn & David A. Stinnett Clinton Medberry, MD Pfizer, Inc. Mary P. Schumacher Sara P. & Walter J. Styer Carla M. Meehan Holly A. Phelps Rosalind Jane Schwam Richard Synder Debrah Meislich, MD Philadelphia Belt Line RR, Co. Kymberly A. Schwartz Evelyn R. Tabas Merrill Lynch & Co., Inc. Philadelphia Federal Credit Union Susan Schwartz Jeanie & Philip Taddeo Will Meyers Rose Pinto David & Laurie Schwartzer Fund Angela C. & Vincent J. Tague Stacey & Douglas Meyer Family Foundation Albert M. Piscopo G. Ross Segal, DMD Joel E. Tepper, MD, PhD Michael H. Sharp & Associates, LLC James Pitkow SEI Investments Company Mr. & Mrs. Joel Thea Samuel D. Miller III

ABRAMSON CANCER CENTER // EXCEPTIONAL 95 Geoffrey C. Thomas United Technologies Corporation Wells Fargo & Company Ms. Cynthia Wishovsky Glenn Thomas, CFP Carmine D Valentino Jr. Richard & Beatrice Wernick Stephanie G. & Albert E. Wolf Bruce E. Tobin Suzanne Walker & Thomas Gilmore Charitable Fund Yogasphere, LLC Dr. Zelig Tochner William Wall White Philanthropic Fund YourCause, LLC Paul V. Tomlinson Rudy H. Walldorf Gregory M. Williams Carol & Charles Zacney Mr. & Mrs. Michael E. Townsend Walldorf Family Fund M. Jane Williams Mohamed H. Zaki, MD, PhD Bettye H. Turitto Eleanor K. Wallen Mr. & Mrs. Quincy N. Williams & Shereen M. Gheith, MD Tzedakah Foundation Nancy D. Weisberg Neal James Wilson, Esq. Susan Zola The Union League of Philadelphia Richard Wells & Rachael E. Wells, PhD Susan G. Wise

CIRCLE OF HOPE $500 – $999 Joseph Abbruzzese Arris Pharmaceutical Robert F. Bernstock Burlington Automotive Nancy E. Abel Arseneault Whipple Farmer Fassett & Azzarello Christine H. & Wade Berrettini, MD Mr. & Mrs. Robert O. Burr Joseph Aboyoun Carolyn H. Asbury, MD & Arthur K. Asbury, MD Michael Bettersworth Charmayne P. Busker Fred M. Abramovitz, MD Atlas Energy Dr. Manish Bhardwaj Philip C. Busker Christine B. & David L. Adams Laura E. Babiarz Mr. & Mrs. Joseph P. Bilson Mr. & Mrs. Robert E. Butler Tamra J. & Robert S. Adams Christina M. Bandish Robert Bitros Joan & Curt Byerley ADCO Electrical Corporation Michael Bantom Robert Gerald Black The Don & Ellen Cacciapaglia Family Fund Margaret & Charles T. Aitken Tony Barbieri Spencer L. Blessing Mr. & Mrs. Charles A. Caffray Dr. & Mrs. Todd Albert Max Bartikowsky Mr. & Mrs. Stephen A. Bleyer Barbara Young Camp Mr. & Mrs. Charles R. Alexy Ellen J. Bauer David Blum Anthony G. Campo Jr., MD Rene Alkoff Douglas Beach Stephen Bonaccorsi Monica Cantz All-Span, Inc. Kathryn Beach Mr. & Mrs. Neil C. Borowsky CardioLogic, LLC Allstate Insurance Company Suzanne & Thomas E. Beach Mr. & Mrs. Louis Bower Joanne W. Carey Michelle Alonso-Basanta, MD Doreva Ann Belfiore Mr. & Mrs. Gary S. Brandeis John Carr Mr. & Mrs. S. Amar David A. Bell Tom Brasberger Patricia N. Carroll Americas Charities Michael Bell The Brearley School Toni Ann Cascaes Adam D. Amsterdam, Esq. Mr. & Mrs. William J. Belter Ann Britton Mr. & Dr. Bart Cassidy Dane O. Anderson Ms. Bonnie Benson Broadridge Financial Solutions, Inc. Caterina Cilluffo Con't, Inc. Trina Andras Hazel & Caspar Bentinck Dr. & Mrs. Alexander J. Brucker Charles J. Schwab Foundation, Inc. ARCO Design/Build Northeast, Inc. Katherine D. Berges Sheila Buek Allison Charney Epstein Max Paul's Ardmore Toyota Scion Mitchell Bergman Mary-Louise F. Burgoyne The Check Cashing Place Greg Arena Berlin Borough BOE Diana Burgwyn Et-Tsu Chen, MD Grace M. Armstrong & Mario L. Maurin Dennis Alan Berman, MD Maureen A. Burke Mr. & Mrs. Ming H. Chen Jeanne Ann Arnold, MD Laurence Berman Nancie W. & G. Theodore Burkett The Chester County Hospital Foundation & Edward Henry Arnold, MD

96 The Cliffe & Cheryl Cheston Charitable Fund Mr. & Mrs. A. Webster Dougherty Jr. Francis, Cauffman, Foley & Hoffmann Meredith Greenberg Catharine E. Chew Douglas F. Bird, Inc. James Frankowski Denelle Green-Drake Michael Childers Ms. Kathryn R. Doyle Gary Freedman Mr. & Mrs. Jay Gress II Choice Hotels International Frederick W. Dreher, Esq. Jerrold A. Frezel Harrison Griffin Mr. & Mrs. Mark E. Clatterbaugh Kathy L. Drew Nancy K & Fred B. Fromhold Ruth A. Grim Rhonda R. Cohen, Esq. Karen Glanz, PhD, MPH Fromhold Jaffe & Adams, Attorneys at Law Carmen Guerra, MD & David L. Cohen, Esq. Duane Morris, LLP Susan & Robert Frutkin John F. Gullace Steven Michael Cohen, Esq. Mr. & Mrs. Francis DuFrayne Lewis M. Gabbe Foundation, Inc. Peter Guzzetti Dr. & Mrs. C. Norman Coleman Catherine & Daniel S. Dumoff Mr. & Mrs. Edward Gabriel Richard A. Haas College of Labor & Employment Lawyers, Inc. Maryel D. Duzan Mr. & Mrs. Robert Gabriel Florence A. Hall Kenneth R. Collins Jr. Eastern HIgh School Softball Joan Garde Lynda Hamby Gene Concordia Edmonson Family Fund Joan L. Garde Revocable Trust Connie Sue Hankee Congregation Tifereth Israel Mr. & Mrs. Josef Edrich Joel Gardner Harmelin & Associates, Inc. of Lower Bucks County Sara Mell Edwards Mr. & Mrs. Jules Gardner Mr. & Mrs. Roger C. Harper Lia K. Conklin Mr. & Mrs. Joseph Ehrenreich Mr. Steven H. Gartner Dr. Marigene Gan Hartker Russell R. Consentino Beverly P. Engiles John J. Gartside Ms. Lisa Kugler Haywood Conshohocken Brewing Co., LLC Diana E. England Ms. Patricia A. Germanovich Stacie Hedrick Constellation Energy Group Ettl Family Fund Andrew Gilleland Karl C. Heine Melisa Cooper, MD & Mark J. Cornfeld, MD Mr. Richard Evoy James B. Ginty Bill Heinemann Corning Incorporated Exxon Mobil Corporation Samuel Giordano Douglas A. Hendel Mr. & Mrs. Peter Costanzo John Fanelli Lauren Gleason Mr. & Mrs. Alan Hershey Cozen O'Connor R. Horowitz & R. Farber-Horowitz Ms. Susan J. Gleckner Margaret Higgins Patricia Crossley Mr. & Mrs. Stuart Feldman Glenmede Corp Hilsberg Family Charitable Giving Fund Patricia B. Cuddy Mr. & Mrs. James R. Fendrick Gary Godfrey C. Toebe Hinckle Michael I. Cyter William C. Fenstermacher Jr. Marc Gold, Esq. Ho-Chun Ho Daniel M. Tabas Family Foundation Massimo Ferragamo Bruce Goldberg Carole S. Hochman Mr. & Mrs. Richard Davidov Finance Company of Pennsylvania Ross O. Goldberg, Esq. Meredith L. & Jonathan Hoffman Dorothy R. Davies & Jeremy R. Kramer Mr. & Mrs. Brian Finn Ruth G. Goldstein Peter Homberg Mr. & Mrs. Daniel Delaney Carolyn Fisher Robert T. Goodman George Horn James S. Deleo David J. Fisher Michael D. Gordin Ann M. Hotung James I. Devine Robert P. Flicker Deborah H. Gordon Marion Hoyle Lara Diamond Mr. & Mrs. Jim Florsheim Dr. Mirian M. Graddick-Weir Rehana Hussain Ms. Mary Quinn DiMauro Brenda Foley Grainger Industrial Supply Immaculata University Toby Director Family Fund Debra Forster Ira Green Incentive Systems, Inc. Lauren B. Dobbin Aileen R. Foster Len Greenbaum Int. Assoc. of Bridge, Structutural Robert W. Doms Foundation LU-Ben Cohen Family Frank Greenberg & Ornatmental

ABRAMSON CANCER CENTER // EXCEPTIONAL 97 CIRCLE OF HOPE $500 – $999 (CONTINUED) International Foundation Thomas La Croix Dr. Mary Ellen Martin Anne Murphy of Employee Benefit Plans Susanna E. Lachs, Esq. & Dean S. Adler, Esq. Dr. Mary E. Martin Mr. & Mrs. Jay R. Murphy Intuitive Medical Solutions, LLC Dana H. & Fabien M. Lagoutte Rick Marts Mr. & Mrs. Joseph Murphy Peter A. Irwin Dr. J. Richard Landis Mary & Harry Klorman Charitable Foundation myCIO Wealth Partners, LLC Jason A. Ivey Mr. & Mrs. William L. Landsburg Mr. & Mrs. Terry B. Mason Suneel Niren Nagda Mr. & Mrs. Edward M. Jacobs Michael T. Laphan Greer K. Massey Dorothy Nardella Lee A. Jefcoats Ann Lapides Joanna Mastronardo Newman & Company, Inc. Beverly B. & Keith S. Jennings Joseph V. Laragione Mayfield Gardens Inc. NIIT Technologies, Inc. JInx-Proof, LLC Randy W. Larimore Joseph McCabe Mr. & Mrs. Andrew J. Nitkin J. Richard Jones Mr. & Mrs. Gary Lassin Michael McCall Noel & Bonebrake Leonard Kallman Joseph E. Lastowka Jr., Esq. Mike McCall Norris Family Charitable Fund Dr. Jill Kane Margot & James A. Lebovitz, Esq. Mr. & Mrs. Jack D. McCallum Dr. Kwabena A. Ntoso Robert N. Kaplan Mr. & Mrs. Stephen V. Lee III Irene L. McCann & Dr. May-Ange Ntoso Dave Kaschak Dr. & Mrs. L. Scott Levin Ed McCarthy Susan F. & Lawrence M. O'Donnell Mr. & Mrs. John J. Kavanagh III Bruce L. Levine, PhD Mr. & Mrs. James F. McGillin Mr. & Mrs. J. Clark O'Donoghue KDC Solar, LLC Emily & Ronald Levine Mr. & Mrs. James D. McIlroy Michael A. O'Farrow Mr. & Mrs. Michael J. Kearns Joan & Harvey H. Levitan Mr. Thomas J. McKnight Ogorek & Company, Inc. Mary Keifer Jean S. Levy James M. Metz, MD Edward M. O'Hara M. Celeste Simon, PhD & Brian Keith, MD Joanne C. Lewers Mr. Jeff Meyers Miss Annette O'Malley Anne M. Kelly Tamara Li Adam Michelin James J. Onesti Kelly & Partners Mr. & Mrs. Sheldon J. Liss John A. Miller Shawn N. Orenstein Thomas E. Kerwin Rosemarie Lomire Jay B. Minkoff OTS Holdings, Inc. Rachel F. Kesselhaut Mairi V. Luce Edward C. Mintzer Jr., Esq. Karen A. Overstreet Madeline & Steven J. Kessler Robert & Lois Luckie Charitable Foundation John E. Mitchell Arzie Owens Cynthia M. King Selina M. Luger, MD Lauren E. Mitchell PACE Academic & Life Coaching Kistler-Tiffany Benefits Anne Macy Marna C. Plourde & Rick Mitchell Mr. & Mrs. Nicholas A. Palladino Ms. Gretchen Kocher Macy's/Bloomingdale's M&M Associates, Inc. William R. Parker William Kohn William Magee Mr. & Mrs. Edward J. Monahan Dr. Christine A. Pasquariello Benn A. Konner Amit Maity, MD, PhD Robert James Mongeluzzi, Esq. Ryan Paul Scott C. Konner Roberta Mann Mr. & Mrs. Vincent Morabito The Penn Law Women's Association Constantinos A. Koumenis Manny & Ruthy Cohen Foundation David L. Morgan Penn Radiation Oncology KPMG, LLP Marcum, LLP Pauline K. Morgan, Esq. Ronald & Jayne Perilstein Philanthropic Fund Andrea Spahn Kramer & Robert Kramer Mr. & Mrs. Lawrence A. Marcus Mullica Hill Cold Storage, LLC John Perone Electrical Contrac Evelyn Krancer John Marsh Rosenfeld Multiflow Industries, LP Jane C. Perry

98 Donald L. Perry Foundation Mr. & Mrs. David L. Rosolia Leslie M. Shaw, MD Robert E. Sullivan for Cancer Research The Elijah Ross Foundation, Inc. Mr. & Mrs. Edward Shensky Gita Suneja, MD Bill Petersen Ross Family Fund Mr. & Mrs. Anthony R. Sherr Mr. & Mrs. L. F. Sutherland David Petty Mathew Rotenberg Hannah H. Shipley Carole G. Swift Mr. & Mrs. Jason L. Petuck Mr. & Mrs. Steve Rotfeld Evelyn Shreve The Sylk Charitable Trust Daria & R. Anderson Pew David B. Roth, MD Dr. Donald L. Siegel & Dr. Leslie P. Kamen Synergy Employment Group, Inc. Pamela D. Trimingham & David A. Pierson Mr. & Mrs. Melvyn H. Rothbard Mr. & Mrs. Matthew J. Siembieda Sysmex America, Inc. PJ Fitzpatrick, Inc. Harry J. Rubin Paul Silberberg, Esq. Tactix Real Estate Advisors, LLC Stan Polk Mr. & Mrs. Paul R. Rubincam Jr. John Silver Talk of the Town Dale Pollak Mr. Peter C. Rubincam Wendy Simkulak Techno-Bloc Corp. Lynna M. Pollard & Ms. Michele D. Rubincam Albert J. Sindoni Mr. & Mrs. James Thistlethwaite Maura Preston Mary Jane & Terry Ruggles Elise E. Singer, Esq. & Donald Perelman Thomas Family Foundation Kimberly W. Prey David J. Rutenberg Dr. Nancy Small Ann A. Thompson Bettina Prober Ms. Deirdre Ryan James W. Smith Ansel Thompson Prudential Insurance Company of America John J. Ryan June Smith Mirium J. Todd Asha Pruthi Sage Financial Group Darlene P. & Michael J. Spahn Edward G. Tolan Farhana Pruthi Saint Andrew School Donald Spector Toll Brothers, Inc. Dr. & Mrs. Parag Pruthi Kathleen Sandelier Spirit of O.C.H.S. Band Boosters, Inc. Dr. Susan F. Townsend Mr. & Mrs. Joe D. Ramsey Jr. Carole A. Sanders Jennifer M. Spotila, Esq. Joseph F. Tringali Spencer F. Rand, Esq. & Dr. Elizabeth Rand Tanja Santiago St. Andrews Foundation Janet Twardowski Rebecca Randall Mr. & Mrs. Richard Scali Mr. & Mrs. John E. Stapleford Tyco Electronics Melinda G. Rath Kathryn Schafer Faye Steele UBM Community Connection Foundation Patricia A. & Edward F. Rebbert Stephanie & Robert W. Scheetz Steinhart Family Trust University of Florida Craig Redcay Mr. & Mrs. Chris Schell David Stelnik Jalaluddin S. Vadsaria The Honorable Marjorie O. Rendell Eric Schwartz Stentor Music Services, Inc. Vanguard Charitable Endowment Program Mr. & Mrs. William F. Rich James Christopher Scott Mr. & Mrs. William F. Stephenson Mr. Sam Vasile Lori Riggs The Seelig Family Foundation Peter R. Sternberg, Esq. Verizon Communications Inc. Mr. & Mrs. James Riley Mr. Norman H. Seibel Kenneth John Stern Trust Annamarie Schorn-Vernot & Robert Vernot Mrs. Judith Gosselin Rock Ann E. Seiberlich Vivienne L. Stevens Caroline Volk Rachel A. Rock Eric Selvage Carleton Stewart Michelle Vosper Raymond R. Rock Debra L. Serano Ridder Mary T. Stiefel Peggy & Ellis Wachs Family Foundation Mr. & Mrs. David A. Rosato Seton Hall University Virginia Stinger Brannon Wait Mr. & Mrs. Philip R. Rosato Robert Shafer Margaret H. Stone Molly G. Walker Mr. & Mrs. Robert L. Rose Richard E. Shandell, Esq. Ms. Jennifer B. Streitwieser Mr. & Mrs. Gregg J. Wallace Phyllis Roseman Alex Shanley Ben Stucker Charles W. Walldorf Mark Rosenfeld Brian Sharples Christopher Stuhl Doug Walsh

ABRAMSON CANCER CENTER // EXCEPTIONAL 99 Jason Walsh Mr. & Mrs. Fred G. White B'nai Jeshurun Timothy C. Zhu Jonathan T. Walton Jr. Mr. & Mrs. Sander I. White Amy S. Wood Ms. Carol A. Zimmerman Meghan Ward Jack L. Williams Mr. & Mrs. Ralph L. Yaffe Cindy K. & P. Richard Zitelman Weinstein Mitzvah Foundation, Inc. Neil Witkes, Esq. Suzanne Yoon Mia Zuckerkandel Ralph Weisgerber Beate Witzler Dennis Young Linda Zylberdrut West Pharmaceutical Services Dr. & Mrs. R. J. Wolfson Stuart B. Young Angie White Women's Association Congregation Arthur Zack, MD & Minnie Cotler Zack

LASTING TRIBUTE Over the last two years, the Abramson Cancer Center has received generous and thoughtful gifts in honor, memory and celebration of the following people:

Dana Seshens Evan Alley, MD Elena Ariano Dr. Ranjeeta Baharwani Faith Basser Cary B. Aarons George Almond Hollis Armstead Mae Gordon Bailis Fannie Basser James Abel Michelle Alonso-Basanta, MD, PhD Dr. Steve Arnold Michael J. Baime, MD Harry Basser Abramson Cancer Center's Leonor Alonzo Walter & Sherrill Arrington Ned Baker Rose Basser 40th Anniversary Oscar Alonzo Keith N. Van Arsdalen, MD Susan T. Baker Charles L. Bassett Jr. Madlyn & Leonard Abramson Bobby Alper ArtNude 2013 Rhoda Ballen Lisa Bates Margie Actman Robert M. Alper ArtNude 2014 David J. Bandish Louis Battalino Judge Arlin Adams Eric Altman Steve Asher Marc H. Barag Christian M. Bauman Marie Adams Thomas Amato Sharon Asnis Nancy Barag Jeannie Bauman Herbert Adelman Ravi Amavaradi, MD Paul C. Astor, Esq. Paul Santa Barbara Kathleen Bauman Belle Adlen John R. Ambrosini Sr. John F. Aubin Linda Barbieri Mary Jo Bayer Phyllis Adorno Margaret "Maggie" Amodei Michael Audet Marc Barcy Deborah Beausang Charu Aggarwal, MD, MPH Harriet Amster Judy Auerback Dr. William Barger Steven Beck Santina Agresta Alan Anderer Rose V. Avolio Jack Barlow Billy Becker Irene Agriss Lester L. Anderson Sr. Sidney Axelman Irma Barness Sarah Becker Peter Ahn, MD Emily Andrade Bart Axelrod Dr. Lewis Barness Saul Becker Margaret Aitken Mildred Faye Andrew Arlen Ayers Lynda Barness Steward Bednoff Daisy Alderfer Hayley Jeanne Annino Linda G. Ayers Susan T. Baron Donald Behler Raymond S. Alexander Jackie Anthone Esther M. Azar Muriel Baronett Celeste Behling Debbie Alfieri Lauren Anton Fred C. Azzara Marc Baroz Leyla Behmoiras Allan's Walk 2014 Amy Joy Apgar Kim Baccino Donald D. Barry Justin Bekelman, MD Ernest Alfred Allen George Appel Marge Bach Barry Barsky Shirley Belfus Jeannie Allen Mary C. Archer Hugh Bager David W. Bartelt Agnes Bell Rosemary Allen Michael E. Arena Jim Bager David Bartelt Chris Bell

100 Arlene Beller Marvin Black Dr. Ben Boursi Armand E. Brodeur, MD George A. Butler Emanuel Ben-Amos Rita Black James J. Bowes, Esq. Phoebe Brodkin Lewis A. Butler Antonette Bender Sandy Blackburn Joanne Bowes Dr. Arthur Brodsky Harry Butson, MD Robin Bender-Stevens Edward F. Blade Sr. Mary Ann Boyer Shari Brodsky Chris Buzby Barbara Bennett Bart Blatstein Mary Boyle Kalman Broitman Hilton Byrd Bonita Bennett Reuben Blavat Julia C. Boynton Dr. Earl "Buddy" Broker Frankie Byrne Dana Bereznak Joseph Blee Cathy Braid John E. Brolley Jeanne Cafferty James Bereznak Scott Blewitt Marsha Brait Amy Bromberg Marianne Cahill Dennis J. Bergen Andrew F. Blickos Marlene Braker Margaret Brooks Amber Calabrese Gary Berger Ed Block Hope Brandeis Nicole Bondi Broome Marie Calo Gwynne Berger Jacquelyn Bloom-Landstein Debbie Branson Marcia S. Brose, MD Emily & Frank Camardo Sr. Mitchell Berk Barry Bloovman Joseph P. Braun Barbara Brown Joseph Came Bernard Bernstein Shelly Blum Charles S. Braunstein Debra Brown Millie Campagna Betty Bernstein Helene Elting Blumental Janet Brazinski Patricia E. Brown Ronald L. Campagna Edith Bernstein Dale Fisher Blumenthal Breast Cancer Patient Richard Brown Kenneth B. Campbell Marty Bernstein Gary B. Blumenthal Education Conference Abbe Connell Bryer Robert Campbell Francis Xavier Berry Janice A. Blumenthal Eugene Brecher, MD Tim Bryson Michelle Hecker Camps Nancy Berry David R. Blythe Gene Brecher James Buchanan Gerald Canary Thomas Berry Richard M. Bockol Alvina Breckel Meta Buchheim Samuel Cander Jean F. Bertucci Joseph Bogansky Edward Bregman Margaret Buck Marilyn Cantor Eugene & Anita Berube Carolyn Bogle Steven Brem, MD Mickey Buck Pepper Cantos James Bettersworth Karen Lavan Bokelman Richard S. BreMiller Neal Buck Gerard Cantwell Charlie Betzold Jennifer L. Bolton Craig Brennan Linda Buckler Donald Canull Packard Biddle Bernice Bomze James Brennan Gary J. Buckwalter Lynne Caplan Henry Bienenfeld Catherine Bonaccorso John Brett Mary Jane Budenz Robert Di Caprio Dr. Douglas Bigelow Salvatore Bonaccorso Martin G. Brickner Ellen Bujnowski Michelina Capriotti Nancy W. Bilheimer Michael Bones Drs. M. Prince Brigham Jane Bulman Jean M. Caputo & Michael Brigham-Burke Lena Binder George R. Bonsall Eric A. Burbano Susan Capuzzi Pam Brilotte Lise Binder Alex Boory Robert A. Burger, MD Nick Carafa Roy Brimer Sadie G. Binder Mr. & Mrs. Barry Borden James Burgoyne Roberta Carbo Sylvia Briselli Prince Birgham Brendan Borek Katherine Burgum Kathleen Cardano Selma Briskin Marilyn & J. Robert Birnhak Karrie Borgelt John J. Burke Cardiac Electrophysicology Center Michal W. Bristol Tracey A. Birnhak Jerome Borgutz Joe Burns Michael P. Carey Carole Britchkow Robert Birzes Sara Borish Robert Bob Burns Ric Carey Lindsey Britchkow Joel Bishop Irvin J. Borowsky Michael Brooks Bush Richard H. Carey Eileen Brode Golf Outing 2014 Annette Black Julie Borowsky Darlene Butcher Herbert Carl Eileen Brode Marianne Black Thomas Boshell Dianne Butler Alice M. Carlin Jeffrey R. Brode

ABRAMSON CANCER CENTER // EXCEPTIONAL 101 LASTING TRIBUTE (CONTINUED) Richard Carroll Carly Chizak Molly A. Golden Cohen Jane Cook Richard J. Cronin Susan Carroll Joyce Chlcote Richard & Kathy Cohen Margaret Jane Cook Gary W. Crooks, MD David Carson III Florence C. Chmelko 50th Wedding Anniversary Walter G. Cook Polly Cross Rick Carson Betty & Gordon Christensen Richie Cohen Alice J. Cooper Geraldine Crowder Barbara Carter Josh Christensen Roger B. Cohen, MD Jane Cooper Lori Cuffari Patsy A. Carter Nicholas J. Christos, MD Gloria Cohen-Dion Sherri Cooper Roseann Cugini Renee Carter Edward Chromiec Alan J. Cohn Susan Cooper Douglas Cummings Joseph R. Carver, MD Mei Hu Chu David Cohn Helene Cooperman Charles Cummiskey Gloria A. Casarez Doris Chudnoff Stephen L. Cohn Betty Lee Cooperstein Thomas E. Curley Sr. John Casey Mae Aronovitz Ciociola Jillian Colasante William C. Copenhafer Tamara Curry Priscilla Casteel Marge Cirigliano Curtis Cole Michael Corine John F. Curtis Patty Castner Michael D. Cirigliano, MD Lorraine Cole Jean W. Cormax John E. Curtis Jeffrey A. Catalano Hope Clair Caroline Coleman Ruth Corwick Kathleen Cushing Joseph Catrambone Amy Clark, MD Robert Coles Italo A. Cosentino Sam Cutrufello Lee Caudill Kathleen Clark Eleanor Colgan Joseph Cosentino Samuel Cutrufello Nancy Cerami Patricia Quinn Clark Joanne Colgan Victoria Cosgrove Marsha Cuttler Frances Cerney Wallace Clark Evelyn J. Coll I. Michael Coslov Mia S. Cyter Anna Cervenak Elizabeth Clement Robin Coll James Costello Brian Czerniecki, MD Stacey Chaiken Gregory Clement Jane D. Colman Jose M. Cotarelo Joseph A. D'Abundo Ara Chalian, MD Phyllis Clemente Jill Felix Colton Elise Cotler Emilie Rene Tilou Dahan, RN Bernice Chambers John F. Clements Colleen Comber George Coukos, MD Dorothy Dale Catherine Chang Deborah L. Clemmer Linda Comber Bernard Cousar Linda Daley Richard Charlick CLL Research Goldye Comisky Brad Coustan Bernard Dall Richard Charny Dolores Clune Karla J. Commerford Michael J. Covine Rena Rowan Damone Alice Chase Mary Lou Cobb Barbara Compton Joseph L. Coward Rebecca Dampf Larry Chatzkel Andrew Kanoff & Emily Coben Earle Compton Connie Cox Chi V. Dang, MD, PhD Beth Chernoff Elizabeth Coby Jane E. Condi Nancy Cobb Cox Lisa Dang Judith Chernoff Ann Coccia Juan Condon Mary Deeney Coyle Hon. Bob Daniels Stephen C.C. Cheung Louis A. Cochet Arthur G. Connolly Jr. Collette Coyne Sean Daniels Carl Chew Adam D. Cohen, MD Eleanor Connolly Annita Cracchiolo Col. Alfred Dann Carol Chew Daniel Cohen Mr. & Mrs. Anthony Conrad Caroline Gallagher Cranston Noelle Datta Brett Chicko Dorothy Cohen Samantha & Steven Constantiner Caroline Cranston Richard Davidov Josh Chilcore Helaine Cohen Mollie Conway Dolores M. Cresswell Jill Davis Cynthia Child Marjorie B. Cohen Brittany L. Conwell Steve Crispi Colonel Joseph Davis Jr.

102 Marge Davis Claude Detweiler James Francis Doherty Veronica Dwyer Tracey L. Evans, MD Sondra Davis Christy DeuBuque George Doll Megan Dychala Tueng Eyimei Edna Davis-Frye Donna Devereaux Liz Dols William F. Earley Lois Feagin Ezzell John J. Davitis Francis Devine Susan M. Domchek, MD Robert L. Ecker Sr. George A. Fahy Bill Davner Tom Devine Lisa Donahue Kevin Edmonds Walter Fair William Davner Elizabeth DeWaele Carolyn Donovan Marie V. Eichhorn Arthur W. Fairclough Kevin P. Day Pauline Diamond Therese & John Donovan Ann Eisman Gary W. Falk, MD Patricia (Nonie) DeAngelo Mario R. DiBenedetto Gerard (Jerry) F. Doody Esther Eisman Marc. W. Farley Jeff Debs Robert T. DiCaprio Mark Dornstreich Mildred Eizen Mark Farley Donna DeCosmo Shirley Diccianni Kenneth A. Dorsett John E. Eksterowicz Raymond & Reno Farnesi Dana DeDonato Joel Dichter Kristine Dorsey Jacqueline Eldred Lori Farquhar Irene Deemer Johh Dick Jr. Dos Segundos ACC Young Friends Lois Elkman Wayne Gower & Jerry Farrell Martin DeGovanni Janis L. Dickey Happy Hour Steven Elkman Marie Farrelly Dr. Sterling F. Delano Kathy Dickinson James Ray Dotson Dolores Ellis Sharon Farrow Cindy DelGiorno William H. Diehl Frederick Dotts Harriet Schneeberg Ellis Lynn Fasy Ferdinando Antonio Dell'Arciprete Lucy DiElsi John A. Doturck Samantha Ellis Carol Fee Rocco DelMastro Diane Dienstman David Dougherty Amiram Elwork Valerie Feeley Tony, Ann, Nick & Steve DeMarco Joan Dierden James Francis Dougherty Edward Ely Madeline Fein Nick DeMeis Jane Dietrich David Douglas Ann B. Emery Alan S. Feinberg Angela DeMichele, MD William R. Dietz Rick Dovey Kathy Engebretson Yetta Feinberg Roberta Demito Marianne DiGiondomenico Aloysius J. Dowd III Jack & Kathryn Engler Mel Feld Victoria Denenberg Vince Dignazio Rita E. Dowd Joseph Eppolito Ellen Jonas Feldman Krishnawatie Deonarain Ronald W. DiLeo Sr. Michael J. Doyle James R. Epps Janet G. Felgoise Margaret Derby-Kauffman Henrietta DiLoretto Abraham Dranetz James Epps Jr. Barbara Fennimore Daryl Derenick Salvatore DiMaiuta Jeffrey A. Drebin, MD, PhD, FACS Eve T. Epstein Raymond Fenti Arati Desai, MD The Dimatatis' New Home Claire Dubin Susan Epstein Larry Ferguson Nimesh D. Desai, MD Donna DiMuro Erma Duffield H. Bernadette Erikson Janet Fern Tammi DeSallis Gina Dinardo Sandra Forrester Dufresne Robert J. Ertell Jr. Elio Ferraro Blaise "Bill" DeSanto Lou DiNunizo John J. Duke Janet Espenschade Terrence R. Fick Antonina E. DeSesa Joseph Dipasquale Linda Duley Meg Myer Esposti Sandra L. Fida Dr. Lalaji Deshbandhu Marcella Elena DiSandro Joseph Dunaway Margaret Myers Esposto Beatrice Fieramosca Matteo Desiderio Frank E. Dischinger Jr. Edwin Dunbar The Honorable Melvyn J. Estrin Pat Fine Madeline DeStefano Lois DiTeodoro Grant Dunn Maria Eustis Michelle Finklea Sandy DeStefano David Dobbin Paul A. Duva Kathy Evans Blanche Finnel

ABRAMSON CANCER CENTER // EXCEPTIONAL 103 LASTING TRIBUTE (CONTINUED) Antonio Fiocca Nancy Merrill Foehl Noelle Frey, MD Rosa Gaudiose Eli Glatstein, MD Sandy First Marc Foley Joseph S. Friedberg, MD Timothy R. Geesey George P. Glenn Jr., MD Edward Fischer Roy G. Foltz Andrew Friedman Christopher Gehlhaus John H. Glick, MD Edwin Fischer Allen Forbes Ed Friedman William R. Geist Jason Glickman Dr. & Mrs. Kenneth Fisher Delores Forcina Eric Friedman Todd Gekoski Irene Glover Carla Fisher, MD Anthony Formato Marvin Friedman Joseph Geller Yakov Gluskia Dale S. Fisher Faith Forrest Matthew Friedman Sherri Gendleman Jason Gmitter Donald C. Fisher Andrew J. Fox – Fox's Fight Matthew Friedman Philip C. Gendron Evan Godfrey Isador Fisher Kevin R. Fox, MD Robert B. Friedman Paul Genkin Blanche Turoff Goffman Jean Fisher Robb Fox William Friel Alix Genter Hope Gold Jerome E. Fisher Nancy A. Fox Sam & Millie Frisch Pamela J. Gephart Elizabeth Goldberg Joan Fisher Ottie Fox Jesse Fronczak Thomas G. Germanovich Sr. Leonard Goldberg Rebecca Fisher Robert D. Fox, Esq. Edna Frye Deborah Ann Gero Louis John Goldberg Robert S. Fisher Mary Lynn Fracaroli Trudy Fuchs Sheila Gerson Max Goldberg Scott Fisher Douglas L. Fraker, MD Jeffery Fuehrer Mark Gettis Rose Goldberg Jill Fishman Janet Francesconi Melvin B. Fuerst, DDS Bruce Giantonio, MD Carl Goldenberg Mark Fishman Brienne Francisco Don & Thelma Fuller Inge M. Gibialante Vivian Goldenberg Seth Fishman Eleanor Frangipanni Dr. James Fulton Beth Gilbert Wayne Goldenberg Joe Fitzpatrick Kathy Frank Roni Funk Gerald Y. Gilbert Gayle Goldglantz Helena Flasza Stephen Frank Sheldon Funk Judith Gillanders Ethel Goldis Cynthia Fleischer Benjamin Frankel Richard H. Gabel Ruth E. Gillespie Henry Goldman Carol Fleischman, MD Jill Frankel Verne Gabin Mary Ellen G. Gilligan Lois M. Goldman Gerald Fleisher Mark A. Frankel Steven Gadon Patricia Gillis Michael Goldman Michael Fleishert Nancy Frankowski Mark. D. Galit Wilburn Gilly Sylvia Goldman Carole Fleming Brian D. Frantz Karen Gallagher Joan Gilmore, BS, CCRP Rebecca Goldner Geraldine Fleming Ken Frantz Trish Gambino Hillel Gindin Brian Goldsmith Linda Flick Alhambra Frarey, MD Lori Ann Gannon Gregory G. Ginsberg, MD David Goldsmith Flip4cancer.com William Frati Freda Gansler Barbara Ginsburg Harold Goldsmith Ruth Flitter Laura Frati Charlotte Garber Carol Giordano Nancy Goldsmith Keith Flood Ruth Fredman Joseph L. Garde Maxine Gitlin Dr. Allan Goldstein Darren Flynn Gary Freedman, MD Shirley Gardner Bernadette Giuliano Blanche Goldstein Agnes I. Focht Allen Freiberg Henry S. Gartner Dr. Robert Giuntoli Elizabeth Goldstein Angie Focht Freshman Experience Steven H. Gartner Arthur Glass Jonathan Goldstein Wayne Focht Residential Program Roberta Gasus, MD Lisa Gushner Glass Ronald Goldstein

104 Arnold Goldstone Mary Lou Gray G. Gushner June Hancox Rabbi Max Hausen Joan Goldstone Mindy Gray Nadine Gushner Matthew C. Haney Michael J. Haut, MD Jerome S. Goodman Mindy Gray's Pink Ribbon Award Evelyn Guskey Nancy Hann Gene Haveson Lawrence Goodman Mindy & Jon Gray's Anniversary Ben Gustafson Irma Hannes Sharon Vautrin Hawkins The Goodman Family Stella Cecile Gray Brett S. Gustafson John H. Hansen-Flaschen, MD Dr. Richard Hayden Annette Gordon Aaron Green Amy Gutmann Joshua Harden Joseph B. Heacock Elizabeth Weizer Gordon Dr. Alfred I. Green Jane P. Guzek Edward Hardie Stephen Healy Lorraine Gordon Arthur Green Lisa Marie Guzzardi Barry Hark Paul E. Heckman Jr. Roger A. Gordon James J. Green Sr. Kara Guzzetti Colleen Harker Erb, CRNP, MSN Gary M. Hellings Sandra Gordon Jos G. Green Maureen Guzzetti Denise Harker Barry Helm Kent Gossett Lauren Morris Green Thomas Guzzo, MD Susan Harmelin Besty A. Blake Henjes Kent A. Gossett Laurence R. Green Andrew Haas, MD Patricia Kellie Harootunian David Henry, MD Andrew Gothel Norman Greenbaum John A. Haas Jr. Annette Harris Judy Herkert Nancy Gothie Micky Greenberg Naomi Haas, MD Bea Harris Ron Herman Carole E. Gottlieb Sarah Greenberg George Haber Helen Harris Seymour Hernes Grace Gottlieb Leonard Greenspun Hunter Haber Joe Harris Wyonnella A. Herr Hayes Gottlieb Jean M. Gregor Grove Haentjens Belinda Harrison Mel Herrin Louis Gottlieb Jacqueline Gregory Andrew M. Hafele Dr. Joseph Harryhill Jacqueline Bolton Herring Tobin Gottlieb Meryl Greig Mary Haffey Donald Hart Dr. Diane Hershock J. Farrell & W. Gouer Ron Greig Rev. David Hagan Lydia Hartman Jacqueline Herskowitz John Govannicci Phyllis Greiner Julia M. Hagan Wendy Hartman George Hettenbach Lisa Grace Betsy Grenfell Dr. Andrea Hageman Lee Hartner, MD Katherine Hetzel Levy Graduations Robin Griffen Steve Hahn, MD Michael Hartsaugh Gloria Heuekeroth James Graham William T. Griffin Stanley J. Halas Donald P. Hartz Joan Heupel Joseph Graham, MD Lynn M. Fasy Griffith Peggy W. Hall Ann S. Hartzell Dr. John H. Hewlett III Karen Graham Jane Grinspan Daniel Haller, MD Jeffrey Hartzell Jr. Elizabeth Hexner, MD Lorelei Graham Leah Grode Magdalena "Peggy" Hallock Ian Harvey Donald A. Hibbard Robert Graham, VMD Stanley E. Grode Eva Halloran Jeffrey F. Harvey Denise S. Hickman Carolyn Marie Grande Mary Esther Grof Drs. Weiss, Roling, MacFarlane Judy Harvey Marjorie Joan Hicks Rebecca Grande Myra Gross & Halpern Steven Harz Margaret Stone Higgins Ramon P. Grapsy Jr. Paul Gross, MD Megan K. Halpin Julia Hasson James Hill Doris Grater Sylvan Gross Michael J. Halpin Sandy Hathaway Mark Hinkel Bonnie Gray DuPont Guerry, MD Mary Kay Hamburger Andrea Haupt Del Hinkle Jon Gray Fran Guidi Harriett Ann Hamilton Gail Hausen Deborah Hinton

ABRAMSON CANCER CENTER // EXCEPTIONAL 105 LASTING TRIBUTE (CONTINUED)

Martin Hirsch Steven Hubert Diane Strom Jacob Cynthia June Michael Barry Katz Miriam Hirsch Joseph W. Hughes Sr. Diane E. Jacob Lisa June Seymour Katz Bryan Hoch Ruth I. Hughes Christina F. Jacobs Jacelyn Kahn Shelly Katz Craig Hock Joanne Hulnic Joseph A. Jacobs, MD Lillian Kalczewski Peggy Derby Kauffman Aunt Peg Hodgen William D. Human Jr. Linda Jacobs, PhD, RN Cindy Kaleck Joy Kaufman Russell F. Hodges Joan Hummel Lisa Jacobs Larry Kaliner Amy L. Kaufmann Maureen T. Hoerning Gerry Humphries Marge Jacques Michael Kalos, PhD Clare E. Kaufmann Alka Hoffman Elizabeth D. Hunt Art Jaeger Apostolos T. Kambouroglou Stephanie Kavanaugh Donald Hoffman Careem Hunte Jeffrey Jaeger Noah Kaminer's Bar Mitzvah Robert Frank Kayros Susan Zucker Hoffman HUP Nurses Allan Jameson Bernard Kanoff Rikki Ke Howard H. Hofmann Rehan Hussain Norma Jarrett Sheri Kanter James Kearney, MD Bessie Hollinger Henry Hutchinson Wayne Jason Christine R. Kantner Stephen M. Keefe, MD Luevada Holloway Frannie Hutchison Shehla Jawid Beatrice Kaplan Edward Keenan Diane Holmes Harold & Carole Hyman Joseph Jaworski Doris C. Kaplan Nancy Keenan Rob Holmes William Hyman Dorothy Weeks Jefferson Gloria Kaplan Keim Family David A. Holst Gregory Hymen Franklin Jelley Grace Kaplan Gloria Keller Caroline Holton William Hyndman IV Christina Jemison Leonard Kaplan Karen Carrera Keller William A. Holubec Patrick N. Hynes Conor P. Jennings Joseph Kaplin Kenneth Keller Jacob Holzman Christina Iaconelli Mariell Jessup, MD Marc B. Kaplin Martha Keller Stacy Hopkins Rita Ignatovig Ellen Krause Johnson Esther Kaplin Stephen E. Kelley Leonard Horn Amy Ingber Gary Johnson Giorgos Karakousis, MD Diane Kelly Sally Horner Patricia Ischiropoulos Mary Johnson Renee Kargen Kevin Kelly David A. Horowitz Carol Isen Robin Johnson Cynthia Karnell Linda Kelly Donald J. Horowitz, DO Mildred Isen Stanley Johnson Joan Karnell Karen Kelso Michael J. Horowitz Gary Itzenson Steve Johnson Kimberly K. Karnell Phillip Kendall Stella Horowitz Shirley Itzenson Dorothy W. Jones Robert L. Karnell David L. Kennedy Sr. James Horstmann Joe Allen Ivey Dorthy W. "Dotty" Jones Staff at the Joan Karnell Supportive James Kerr George R. Horvath Joan Jablonski Edwin Jones Care Program at ACC Judy Kerzner William Hough George C. Jackson Jr. George Bryan Jones Jr. Ray Kartanowicz Madeline Kessler Francis P. Houston Sr. Marian E. Jackson Dr. Josh Jones Anthony N. Katra Dr. Robert Kessler Michael J. Howard Jr. James Jackson Tali Ben Joseph Bertha Katz Norman S. Keustner Stephanie Giles Howard Jim Jackson Jr. Everett Jude Elkan Katz, W'67 Annamarie "Nancy" Kiefaber Susan Howarth Howard C. Jackson Karni Judith Gerald Katz Nancy Kiefaber George B. Howell Willie Mary Jackson Carl H. June, MD Lynn F. Katz Stanley Kieserman

106 Ellen J. Kim, MD Joseph M. Kosturski Samuel Lamanna Kimberly Lee Joe Lilavois Alan R. King Gertrude Kotlar Eddie Lancaster Dr. Lara Wine Lee Athena Lillys Susan Kirchoff Julia Kotler Roy G. Lance Linda Lee Alexander Lin, MD William Kitzinger Elefteria Kourelis Danielle Target Land, CRNP Patricia Lee Lilie Lin, MD Thomas Kitzinger Stephen Kovach, MD Teresa Land David I. Lee, MD, Golf Outing Jennifer Rie Van der Linden Sylvia Kivitz Dr. Miriam Kozin Max Landau Frieda Lefeber Adelina Lingenfelter Diana Kizis John W. Krajewski David Landsburg Robyn Fuchs Leftkowitch Mott Linn Richard S. Klawans Jack Kramer Jacquelyn Landstein Robin Leftwich Edythe Freeman Lipinsky Gussie Kleiman Roger Krane Edward C. Lane Maxine Leibowitz Gertrude Lippman Nelson Klein Mary Krause Oscar Lang Carole A. Lenett Carol Lippy Marvin Kleinman Maria Kreiger Corey J. Langer, MD Amy Lengel Dee Dee Lipshutz George Emil Klima Nancy Krell Geraldine Langston Arlene T. Lepore Dr. Philip Lisan Barbara Kline Rob Kresberg Lillian Lankenau Gerry Lero Faye B. Listman Charles Kline Veronica R. Krisch David Lapos Frank P. Lesh Pearl Littman Arnold Klingenberg Darren Kroupa Diana Larkin Frank J. Lesh Renqiang Liu Marc Klingsberg Patty Kruger Dorothy Larks Omeise Dorsey Leslie Charles D. Lockwood Samuel Knable Valerie Jean Kruzick Donato LaRossa, MD Richard A. Letwinch Arlene G. Loecke William A. Knipe John Kucharchuk, MD Larry's Legacy Marvin A. Levey Dr. Walter P. Lomax Jr. Penny Knowles Abraham Kuller Oksana Sum Larson Barbara Levin John P. Lomire Michael Kochman, MD Christian Kuntz Sr. Gregory F. Lastowka Bob Levin John Lomire Mildred Kohn Jozsef Kupecz Joseph E. Lastowka, Esq. Esther Levin Robert Long Ursula Koldorsky Aron Kuppermann Joseph Law Sylvia Levin Fred Loomis John Kolea Jr. Barbara Segal Kuptsow Penn Law Class of 1953 Bruce L. Levine, MD Alison Loren, MD, MS James D. Kolker, MD Victor Kurtz Richard E. Lawson Herman Levine Florence A. Lorenz Kathleen Kolodziejski Ann Kutch Bebe Lax Phyllis R. Levine Ron Lorenzon George Komishock Susan Kuzilla Theresa Le Robin Levine Herbert Lotman Kevah Konner Bob Kyler Tuttieu Thanh Le David Levinson A Love For Life Michele Konner John P. Lacey Patti Leahy Sandy Levinson Isobel Lowrie Gerald Korin Kenneth F. Ladley Gladys E. Lease Sharon Levy Margaret Lowry Jeffrey Matt Kornblau, Esq. Judith Matthews Laffan Edward N. Leavy Joan Lewers Jeanette Lozak Denise A. Kosman Dana H. Lagoutte Helene Lechter Bill Lewis Frances Lube Stanley Kossoff Jeff Lagowitz James P. Leddy Celeste P. Lewis Irene Lubin Anthony J. Kostick Steven Lahav David Lee, MD Grace Lewis James Lucas Libby Kostoff Erdeen E. Lake Deborah D. Lee Lindsey Licthman Sandy Ludica

ABRAMSON CANCER CENTER // EXCEPTIONAL 107 LASTING TRIBUTE (CONTINUED) Mary E. Ludlam Andrea Malek Robert G. Martin Dion McClarin Betty Meltzer William Ludwig II Nandini Malhotra Barbara Martosella Holly McConville, RN, BSN Antonio Mennella Sadie Jean Luehrs S. Bruce Malkowicz, MD Anthony Martucci Martin Leigh McCormick Fred J. Merlie Selina M. Luger, MD Maureen Mallon Dharam P. Marwah Sean McCormick Gregory Merrill Richard D. Lunardi Susan Mandel, MD Francesco A. Mascaro Jane McCoy Pat Merrill Tara Valentine & Mark Lunardi Jim Maneri Julia Masi Joan M. McCoy Carmen Mesina Regina P. Lynch Dr. James Mangan Muriel Maslin Scott Alexander McCraney Joseph Messine David Lynn Richard Steven Manin Julia K. Masnik Robert McCullough Jr. Thelma Messinger Joseph Lyons James Manley Bob Mason Ann McDevitt Catherine Metricardi Dr. Margaret Lytton Rita Manning Dr. Roslyn Mass Margaret Anne McDonald David Metz, MD Vida Lyver Robert Manning Dr. Mina Massaro Florence Travis McDonie James L. Metz, MD Deidre MacAllister Jun Mao, MD Mastbaum Family Helen McEwing Warren Michaels Cornelius Macauley Lou Marano Sharon Masterson Jerry McGeehan Matthew Michlinski Mary Mack Alfred Marcellino Dr. Luigi Mastroiani Rinda McGoldrick Thomas M. Mikolai Julius A. Mackie Jr., MD David Marcheskie Sr. Gilbert "Gil" Mateer James McGorry Tom Mikolai Carol Mackin Frank Marchiano Joe Matera Dr. Cindy McGrath Carl Miller Dr. Michael Macon Frank Marchlinski, MD Phyllis Mathis Barbara McGugan Christopher Miller, MD Jack Mandl Macy Ginny Marchuk Anthony Mato, MD Johnny McKeever Diane Miller Dr. Robert A. Madden Sandra Margolies Carol Ann Matoboni Helen A. McKeon Gloria Miller Bayla Madeline Sonny Margolies Naomi Matsunobu Beth Anne McKeown Harriet Miller Frederic Madonna Harris R. Margolis Joseph Mattero Catherine M. Heine McKissick Harry Miller Joel Magaziner Lauren Margolis Michael Mattero Richard McMurtrie Joan Miller Clarice Maggio Joanne Maricle Susan D. Mattero Joseph McNichol Kathy Miller Mario Maggio Nicholas Marino William A. Matthews Bernice McPherson Keith Miller Jeff Magill Alan Markovitz David M. Matushik Joanne M. McQuirns Mary Ann Miller Phyllis D. Magill Donald E. Marshall Jr. Mario Maurin James McSparran Sally Woodward Miller V. Diane Magrisi Jerry Marshall Marilyn Virgina May James Francis McSparran Dr. Stephen Milliner Monica A. Maher Lynn Marshall Gary Robert McAnelly James T. McVeigh Jr. Rex Millsap Gwen Mahjoubian Bruce Martin Donald P. McCabe Michelle Meehan Jessica Millward Najjia Mahmoud Georgia Martin Mary McCabe Sean Meehan Michael Ming, MD Michael Maiocco Joel John Martin Phyllis McCabe Melanoma Patient Education Jane Mingey Arthur Makadon, Esq. Nancy Martin Kathyrn McCalla Conference Gina Mingioni Joseph Makovetz Paula Williams Martin Christopher McCann Thomas E. Mellon Jr., Esq. Ginny Minnich Renee Mal Paula B. Martin Bruce McCarty Joseph Meltser David M. Mintzer, MD

108 Marion Mintzer Joyce Vance Mount Edward Netter Jack O'Hara Henry D. Palutis William H. Minyard Moving Forward Fundraiser Joyce Neumann Kaytie O'Hara Deborah Pannebaker: SEI Cares Esther Miriam Jennifer L. Mowbray Lee Neumann Mark O'Hara, MD Employee Initiative Kathy Mitchell Julie Mozes The Neuro Surgical ICU Paul O'Hara Donald Paparone Gail Mitura, MD Helene A. Muffett at Pennsylvania Hospital Sean O'Hara Jacqueline Paparone Joseph Mogil Maureen Mulholland Michael Jay Neustadter Marlene Olshan Leon Pappas Elaine Molnar Ryan Blaine Mullen Milton Neustadter Cindy Olson JoAnn Paramonte Carmela Molteni Virginia Mullen Albie Newberg Elizabeth Olson Marjorie Parelman Mandy Monaghan William G. Mulvey Jack Newhouse Anne O'Malley Ottavio Parenti Samantha W. Monaghan Larry F. Mungiola Roy Ney Bert W. O'Malley Jr., MD Joseph Parise Carol Moneymaker Grace Lee Murphy David Nicklin, MD Shaun F. O'Malley Erika Parker Larry F. Mongiole William Murphy Eileen Nikander James F. O'Neill Jr. Linda Sue Parker Brian D. Monihan Diane S. Murray Edward A. Nodiff Ken Ongsueng Peter D.S. Parkinson Caryn O'Connell Monk Hubert A. Murray Ellen Nolan Eugene Orandosh John Parr Breast Cancer Awareness Month Joan M. Murray Dorothy Novrocki Frimi Orel Herman Parris Joe Moody Helen Murray Peter C. Nowell, MD Ida Irene Oreman Millie Pashinski Linda M. Moore Joseph Murray Jr. Leona A. Nubbymer Joan Orlando Charles Pasley Leroy F. Morgan Arthur Mustardi Lawrence C. Nussdorf, Esq. Joshua Orlow David C. Patterson Mark A. Morgan, MD John W. Myers Jr. Lillie May Nutter Gregorio S. Ortanez, MD Debra Patterson Naomi Morgan Sylva Naden Bart Nydish Shari Orzehoski James W. Patterson Robert Morgenstein Milo M. Naeve Maureen Oakley Donna Ostroff Richard J. Patterson Hattie Morin Diane Nangle Edward Oberman Tim O'Sullivan Jr. Shelley M. Pauch Emma Morris Binney W. Nast Rosemary O'Connell Tom O'Sullivan Sr. Rider Atith Paudi Kathleen Morris Sunita D. Nasta, MD Joe O'Connor Charlie Otranto Judy Paul Kimberly Whittaker Morris Beth Neary Maria O'Connor Keith Overberg Robert Paul James R. Morrison III Charles Needleman Nancy O'Connor Jean Pachelbel William Patrick Paul Mary Alice Morrissey Eileen Neff Arlene Diamond Odell Michael Paciocco Shannon Paules Keith E. Morrow Winthrop Neilson III Margaret O'Donnell Robert Pagni Dina Pavel Kristen Serley Mortenson Grandma Nellie Peter J. O'Dwyer, MD Mary Pahl Lambert Payne Jr. Harriet Moscow George James Nelson Carol Oelschlegel Mary Jo Palka Ronald H. Pearlstein Judy Moskow Peter Nelson Valerie M. O'Farrow Seth Palmer Audrey Pedrick Vince Mosse Karl Nelson Helen E. Ogg Diane L. Palmieri Raymond Pellegrini Arthur A. Mostardi Peter Nelson Terence Oglivie Dorothea Palsho Nicholas Pellitta Sheela Moudgil Jane Nemeth Anne O'Hara Michelle E. Paluch Penn Club Spinathon

ABRAMSON CANCER CENTER // EXCEPTIONAL 109 LASTING TRIBUTE (CONTINUED) Marge Pennell Joan M. Piscopo Pressman Poker 2014 Betty Reader Tony Rick Robert Pepe Joe Pizzirusso Pressman Poker 2013 Elaine Reagan Samuel J. Rife 250th Perelman School Greta Platt Pressman Poker 2015 Rajender Reddy, MD Esther Riffkin of Medicine Gala Susan Pleener Michael A. Prevor Searle Redfield Jacob Riley-Wasserman Simone Perloff Richard J. Pogach, MD Dale J. Price Heidi Reed Alfred C. Rinaldi Gerard Pernot Lucian Poli Warren A. Price Margery N. Reed Michael Rinaldi Kenneth Perry Thomas Poli Yoga Program Walter G. Reed Cathy Ringer Susan Thompson Perry Emily Sholtis Polk Ashley Prokopovits Betty L. Reeder Sharon Ringley Nicholas Persichetti Marvin Pollow Michael J. Pugliese Michelle M. Reese Margaret Rios Samuel S. Persky Thomas B. Polulak Joseph J. Pulaski Reiki Volunteers Edward A. Ritter Ross Peters Ali Pomeroy Louise Pullia Joan Reilly Riverdale Soccer Tournament 2014 Adrienne Petiychor Marguerite Pomeroy Thomas A. Quackenbush Patricia A. Reilly Margaret Giampino Rizzi Joseph Petka David Pone Phyliss Quatrone Emily Reiner Hilda Rizzo Eugene G. Petoukhoff Sharon T. Poore Jeff Quig Jason C. Reinhart John J. Rizzo Adrienne R. Petrycki Mary Porreca Joseph A. Quinn Jr. Theodore W. Rendfrey Kim Robel Dennis Pfender John J. La Porte Josephine Racciatti Debbie Valone Rennie Rayford Robel Amy & Sean Philipp's Wedding David L. Porter, MD Allison Rago, RN, BSN Pancreatic Cancer Research Wayne Robel Herbert Phillips Sandra L. Porterfield Sandra Rake Ran Reshef, MD John Roberto Dr. Peter Phillips Sari Portman Kevin L. Rakszawski, MD Kelly Resinger Lance Corporal Anthony P. Roberts, Jafa Phillips Ernest Posner Isaac Rand Shirley Resnick USMC Philly Fights Cancer Lexie Potamkin Spencer Rand Ellen Reukauf Joshua Roberts Philly Fights Cancer Committee Len Potter Anne Rappaport Walter J. Reynolds Sr. Gerald Robinson Photopheresis Department Shari B. Potter Bernard Rappaport Richard C. Rhoades Robert P. Robinson Karen May Piccinini Rose Poulshock Bruce Rappaport Nurses, CNAs & Staff of Rhoads 7 Anthony D. Rocca Lorrainne E. Piccone Arthur Powell Jerry Rappaport Arthur Rhodes Albert Rocha Picket Post Swim Team Swimathon Bob Powell Sidney Rappaport Bailey Rhodes Daniel Rock Robert Pickett Daniel J. Powell, PhD Chuck Rash Beverly Rhodes Patricia A. Rock Herbert Picus Jill Powell William Rate, MD Justin Rhodes Rhea Rockower Jigifredo Piedrabite William Kearney "Bill" Powers Kathryn Ratner Ride to Conquer Cancer Patricia Rodarmel Nancy B. Pierce Mary Powers Judith Rauer Barry L. Rich Bruce Rodger Paint the Town Pink Margery Preddy Sarah Rayers Joseph Richardson Roseanne Roetz Ellen Friedland Pinkus Hilda Pressler Arthur G. Raynes Dr. Paul A. Richardson Kathleen Rogers Lauren & Stephen Pinkus Bab Pressman Dario Rea Richard R. Richman Roy A. Rogers Marie & Anthony Pinnie Ella Sage Pressman Maryann Read Stanley Richmand Velma Rogers Robert Pinto Joseph Rogoff

110 Dick Rogovin Dr. Marvin Rosner Antoinette Rutherford Frank P. Scarpato Jr. Carol Schwartz Carol D. Rolewicz Anna Ross Susan M. Ryan Joanne Schaaf David S. Schwartz, MD Mark C. Roman Charlotte Frutkin Ross Sandra Ryeom, PhD Jeanne S. Schachter Eileen Schwartz Eugene Romanies Michael Ross Andrew Ryles Bruce Z. Schaffer Elliot Schwartz Mark Romanz Shirley Ross Nancy Sabo Clarence Tanky Schaible Evelyn Schwartz Patti Romejko Natalie Rossi, MD Albert E. Sacco, MD Jane Schamban Gerald P. Schwartz Alain H. Rook, MD Matthew Rotenberg Dominic Sacco James L. Schauer Janet Schwartz Andrew Rooke Maya Jocelyn Roth Gary Sackett Joanne Schell Jerry Schwartz Margie Rooke Rudolf Roth, MD Sidney Sacks Richard Schenk Joan Schwartz Ernest Rosato, MD Terry Roth Saks Holiday Sale benefitting ACC Joseph T. Schetroma John Schwartz Sarah Marie Rosato David Rothman Saks Key to the Cure Event Bill Scheuren Laura Schwartz Elise Rose Jennie Rotondo Dr. Michael Salkin Bari Schlesinger Jerry Schwartz Jerry Rose Kathleen M. Rotz Ann Salyard Zoe Schlessel Dr. Robert Schwartzman Kathleen Rose Rena Rowan Breast Center Staff Ron Salyer Heinz Schleyer Juanita Scipio Marylee Rosemont, PA Moshe Rozenblit Florence Samet Franz Schmidt Winetta Scipio Gabi Rosen Michael Rubello Arlene Sampson Arthur Levine Schneeberg Gertrude Scolaro Maxine Rosen Art Rubin Beth Samuels Helen B. Schneeberg Joseph Scullin Marion Rosenberg Arthur Rubin Rana Samuels Myron Schneeberg, MD Will Sears Marvin Rosenberg Dr. Joseph Rubin Antonio O. Sanchez Lucy Schneiberg Jennifer Segaloff Lynn Rosenbloom Stephen Rubin, MD Cheryl Sanchez Joseph F. Schnell Janet Seibel Bruce Rosenblum Hy Rudin Norman Sanders Karen Schor Janet Seiber Jeffrey Rosenblum Gerald Rudman Tom Santoro William Schreiber Gale Seider Judy Rosenbluth Mary Porreca Daniel Santos Steve Schroeder Joyce P. Seidman Dick Rosenbluth & Jim Rudman's Wedding Gerry & Lewis Sare Lynn M. Schuchter, MD Paula Seidman Henry Rosenfeld Michael J. Ruggirello Dahlia Sataloff, MD James W. Schum Sandra Seidman Lester Rosenfeld Rick's Run Bette J. Saul Marybeth Schumacher Chelsea Seigal Mona Rosenfeld Mary Rush Kevin Saul Judith Penn Schur Lizbeth Seland Rachel Rosenfeld Dr. Matthew Rusk Mary B. Sautter Stephen J. Schuster, MD Lizbeth Selano Lisa Rosenstock Mark T. Russo Nancy L. Sautter Veronica A. Schuster Michael Selletti Stanley Rosenstock Patricia Russo Nancy Burns Savage Ellen Schwab Barb Selletti Larry Rosenthal Frances Russomano Frank Savarese Alvin Schwartz Richard Selman Phyllis Rosenthal Michael Russomano Lydia Savarese Alvin Schwartz Florence Sendrow Robert E. Roses, MD Lawrence C. Rutenberg William H. Savidge Jr. Ben Schwartz Mary K. Senkarik Tiffany Joy Roshoe Rebecca Rutenberg Melanie Scalpello Burt Schwartz Gail S. Sentman George Ruth

ABRAMSON CANCER CENTER // EXCEPTIONAL 111 LASTING TRIBUTE (CONTINUED)

Gail A. Sentman Joan Shuster Eileen Smeader Joanne Marie Sonnelitter Marilyn A. Stadalius Joseph M. Serletti, MD Edie Fox Siegel Albert L. Smith, MD Michael J. Sonnelitter Arthur P. Staddon, MD Shelly Serota Robert Siensa Albert Lee Smith III Linda Sonnelitter Edward A. Stadtmauer, MD Andrew Shafranich Dr. Donald H. Silberberg Anne Smith Lavis Sonzogni Welcome Desk Staff Deborah Shandell Ellen Silberman Beverly Smith Joseph Soo Cynthia Lippincott Stamos Donald P. Hartz Melvin Silberman Carol B. Smith Cheryl Sorbello Bonnie Stanfield & James L. Shann Wedding Jake & Amanda Silpe Catherine Smith Sam Sorbello Phillip Stead James Shannon Jenny Silver's Graduation Dennis Smith Anthony Sorrentino Phyllis Stearman Abraham Shanzer Judith Silver Frances Smith Marie Sosdorf Santa L. De Stefano Jules Shapiro Dr. Marvin Silver Harold Smith Sr. Michael Soulen, MD Martin Good Stein Julius Shapiro Maxine Silver Harold Smith Jr. Manuel Sozinho Michael & Tammy Steinberg Richard Shapiro Lisa Silverman Lynne Marie Smith Carmelo Spadaro Philip Steinberg Morris Shatman Alec, Emma, & Jonathan Silverton Mariette Smith Carmen Spadaro Dr. Stanley Steinberg Carol Shaw Doris Simkovitz Mary L. Smith Thorne Sparkman, MD Ann L. Steiner, MD Henry Shaw Cheryl Simmons Robert Smith Anne W. Sparks Joan Steinert Kristy Shea Charles B. Simone, MD Schieffelin Smith David Sparks Claude C. Stephenson III Mary Sheppard-Kurtz Frances Simone Sidney Schieffelin "Chef" Smith III Grace Speakman Clare Foresta Steranka Joseph Sher Steven Simone Sue Smith Dr. Scott Spear Frank Sterling Dottie Sheridan J.R. Simpkins Tara Smith Edward Spector Daniel Sterman, MD Anita C. Sherlock James C. Simpkins Theresa Smith Norma & Julius Spector's Daniel B. Stern Barbara Sherman Margaret E. Simpson Trudie Smith 60th Wedding Anniversary Jennifer Stern Howard Sherman Megan Simpson-Burke Trudie Smith Edmond Spelman Michael Y. Stern Jack Sherman Stanton Sims Myra Smulyan Kyle Sperry Dorothy Stevenson Ron Sherman Dr. Lorie Sinese Brenda Sneed Walter Skip Speth James P. Stevenson, MD Victoria Sherry, MSN, CRNP Sunil Singhal, MD Janet Snyder Lenore Susan Spiegel James Stewart Samuel L. Shimer Vivi Siskos Joel Snyder, MD Giovanni Spinosi Theresa Stewart Yetta Shipon Phil Sky John D. Snyder John Spinosi Frank Stiefel Emerson Shivers Sr. Malcolm L. Slater Ralph Snyder Michael Spinozzola Marcia Stillman Janet Shoemaker Tarn N. Slater Rosalie Snyder Spin-Yarn-A-Thon Mary Stimmler Dr. Louise Shoemaker Joann Slavin Roberta Sochanski Barbara Ellen Sponhauer Rita Stine Douglas Shorenstein Harriet Slogoff William G. Sollott Ken Sprankle Joan Stinsman Harold Shorr Edward J. Slowik Judy Solomen 2014 Spring Soccer Tournament Laurie Stoelting Arthur Shoyer Edward V. Small Marvin Solomon Richard Spychalski Raymond R. Stoffel Marc Shrier Edward Smeader Dr. Meyer Sonis Lynda Squidd Robert Stoffel

112 Marshall Stomel Andrew Tartaglia Edna May Timory Richard Vague with Cancer Susan S. Stonehouse-Lee, John R. Tartar Anthony Tirico Fidel L. Valencerina Norman K. Walker MSN, CRNP Patricia Tashman Maureen Tirico Kathleen Valentino Danielle Wallace Francine Strauss Patty Tashman Karen M. Tobia ACC Valley Forge Kathy Wallace Mary Streahle Gloria Taub Lisa Anderson Todd Romano Vallorani Mildred Wallace Kenneth Stringer Bob Taylor Jane Tola Robert Vanarsdall, MD Elizabeth Walter James P. Stuhlman Debbie Taylor Hortence Tonner Sandra Vanarsdall Brian Walters Frank J. Stulb Jr. Fran Taylor Nancy Tooker Wim & Nicole Vandenhouweele Elizabeth Walters Isabella Sucstakova Joan Taylor Arline Sandy Torres Neha Vapiwala, MD Michelle I. Walters Kate Sullivan Judith Taylor Riverdale Tournament Barbara Vaughan Wilbur Wampley Robert Summers Monica Taylor Bambina Townsley David Vaughn, MD Terri Lynn Warm Naya Summy Robert L. Taylor Edith Toye Dan Velders Patricia Warner Weijing Sun, MD Tina Taylor Mark Trachtenberg Christopher Vellner Susan E. Warner Heather Sutton Alisa Taylor-Fuente Bernadette L. Trahan Joseph Venuto Michele Washburn Ellen Svitek Julia C. Tchou, MD, PhD Edward Trainor Sylvester Venziale Jeannette R. Waszewski Frank Svitek Ursina R. Teitelbaum, MD Mrs. Hedwig Tranchitella Kim Vernick Florence Waters Jakub Svoboda, MD Hazel Tello Arlene Treegoob Beth Victor Faye Louise Watkins Laura Keeler Swartz Adam S. Tencza Carol Treiman Gerald Victor Kevin Watkins Peggy Mae Swartz Leonard Terranova Sr. Michael Trois Kelly Ann Victor Geoff Watson Ronald Sweeney Karen Testa Matt Smyth Turkey Trot Michael Viola Samantha M. Watson John T. Sweitzer Louis M. Testa Sr. Nina Trubchanina Herman Vogel Elizabeth Watters Thomas Swietanski Sharon Testa Kay Tuch Dan Vogl, MD Harvey L. Waxman, MD Roselie Sydner Wendy Testa, Esq. Karen Duff Turnbach Veronica Voigt Lawrence G. Weathers Jr. Edward L. Szakacs Erica R. Thaler, MD Marija Turner Luan VonBargen Lisa Keller Weaver Linda Szurek Dayneice Thelma Robin Twaddell Robert H. Vonderheide, MD, DPhil Mike Weaver John Tabtar Anne M. Therwanger Cary S. Tye Joyce Votto Barbara L. Weber, MD Jenn Taddeo Jacalyn S. Thomas, RN Elsa Tymowczak Alan Vukasovic Frank Weber Bruce Talasnik Jennifer Thomas Betty Umbenhauer Barry Wade Haley Schneider Weber Kelly (Magee) Tallarida Preethi Thomas Joe Urban Inez Wade Kristy Weber, MD Laurie Tams Laura Thompson Marcella Ridder Urban Gilbert Wagenfeld Paul Weidner Janos L. Tanyi, MD Dr. Neil B. Thorne Geraldine Urbano Moreen Waight Edmund Weigle Shirley A. Tardio Dr. Leonard J. Tierno Josephine Urbano Scott M. Waldman Katya Audrey Weil Sophia Tarpin Anita H. Tietjen The Department of Urology Alan's Walk Herbert Weiman Sr. Benjamino Tarquini Donald Derrick Tillman Karim J. Vadsaria Walk 4 Family & Friends Alan J. Wein, MD, PhD

ABRAMSON CANCER CENTER // EXCEPTIONAL 113 LASTING TRIBUTE (CONTINUED) Edward L. Weinberg Beth P. Williams Richard J. Young Judith Weinberger Helen Williams Young Friends of ACC – Charlotte Weiner Margery Willis Evening at R2L Leon Weiner Wanda Hillen Windland Young Friends of ACC – Strike Out Cancer Gregory S. Weinstein, MD Rebecca Windmueller Barbara Youngs Maxine Weinstein Hanna Wise Edward Yudof Morton Weinstock Kathleen Wisniewski Jiri V. Zak Randy Weinstock Laura Witte Barbara Zakroff Joseph Weir Alan Woinsky Tedda Zakroff Susan Weisgrau Gary Wojciechowski Janice Zampino Brendan Weiss, MD Nancy Wojciechowski AS AN ATTORNEY, I HAVE SEEN Robert Zardus Christine Weiss Leonard Woldoff Eileen J. Zarin Jack Weiss Robert Wolf MANY PEOPLE BENEFIT FROM Marlene Zarwin Larry Weiss Emily Wolfson Frank Zdeb Robert Weiss Nancy Wolfson USING CHARITABLE GIVING Norbert Zeelander Richard Weissman Dr. Nessa Wolfson Jennifer Zelley Gornnert Phyllis K. Weisz Susan Wolfson VEHICLES. A PLANNED GIFT Gary Zepp Dr. Arvel Wells-Kargbo Robert Wolfson Diana Zervanos Marvin Welsch Neil Woloff ALSO HELPS TO ENSURE THAT Nikitas Zervanos Walter Weniger Shirley Woloff Robert Ziegler Mark Wert Ella Mae Wonder RESOURCES ARE IN PLACE Frances Ziemba Hinam Werth Carla Wood Jess Ziembicki Michael West David W. Wood, MD TO CONTINUE LIFE-SAVING Emily Zilber Michelle West Susan Woodman Tim Zimmerman Marcia P. Wheeler Wilfred Woodward RESEARCH AND PATIENT CARE David O. Zinkz Robert Wheeler Marilyn J. Woolkalis, PhD Robin Zola Robert Wheelock Richard Wortzel, MD, PHD INTO THE FUTURE. Stanley Zolot Wayne L. White Shirley Wurzak Robert A. "Bob" Zoltek Claire M. Whitehill Leonard Wurzel Barbara Zoltiek Jazlynn Deneen Whyte Deborah M. Xaphes Naomi Zondag Libby Wiesner Raymond Yarnall Jr. Arnold Zunick Stephen Wiesner Kassaye Yitaferu — Stephen A. Cozen, Esq. Dr. Burton Zweiman Dr. Barry Wilderman Bill Yoshimura Partner in Hope Lori Zytkowicz (pictured with wife, Donald S. Wilf Laura Yost Sandra Cozen)

114 PLANNED GIVING Planned giving provides a way to make a difference in the lives of others and give back to the community, while achieving personal financial goals. The Abramson Cancer Center has many planned and creative giving opportunities that enable you and your family to establish a lasting legacy and provide hope to those touched by cancer.

Generous donors include:

Geeta Narendra Ahya Kenneth R. Johnson Spencer L. Blessing Morton A. Langsfeld III Estate of Jay A. Bromfield Margaret J. Leonard Estate of Ellen Bugnowski Thomas F. MacAniff Estate of Matthew J. Derham Estate of Joan M. Murray Lowell H. Dubrow Estate of Joseph C. Romano Lois Elkman Estate of Margaret Sherman Ann F. Enders Estate of Richard L. Storch Robert L. Frank Selma S. Sugarman Barry Galman Nancy Gillen Williams Estate of Lester A. Goldstein

Gifts listed here include those individuals who are known to have made a planned gift directed to the Abramson Cancer Center between July 1, 2013 and June 30, 2015. If your name does not appear and you have included the Abramson Cancer Center in your estate plans, or if you would like any additional information, please contact 215.898.9487 or [email protected].

ABRAMSON CANCER CENTER // EXCEPTIONAL 115 GIFT OF HOPE

Like every patient, each donation we receive is special and important. A gift to the Abramson Cancer Center lives on beyond a lifetime. Whether given in memory, in honor or in celebration of anniversaries, birthdays or other special occasions, a contribution in the name of a loved one plays an important role in the Abramson Cancer Center’s ongoing ability to develop new avenues of targeted research, effective cancer prevention and detection strategies and compassionate approaches to patient care.

0411604 Individually, each person can make a difference; collectively, the many friends of the Abramson Cancer Center are helping translate discovery into cure.

Ways to Give ONLINE PennMedicine.org/Abramson/Donate GIFT OF HOPE EMAIL [email protected] PHONE Like every patient, each donation we receive is special and important. 215.898.0578 A gift to the Abramson Cancer Center lives on beyond a lifetime. MAIL Whether given in memory, in honor or in celebration of Abramson Cancer Center Development 3535 Market Street, Suite 750 anniversaries, birthdays or other special occasions, a contribution Philadelphia, PA 19104 in the name of a loved one plays an important role in the Make gifts payable to the Abramson Cancer Center’s ongoing ability to develop “Trustees of the University of Pennsylvania” new avenues of targeted research, effective Create a personalized giving page to encourage friends and family to donate in honor of cancer prevention and detection strategies and your loved one, an event or special occasion at compassionate approaches to patient care. GIVINGPAGES.UPENN.EDU.

ABRAMSON CANCER CENTER // EXCEPTIONAL 117 VIEW ONLINE PennMedicine.org/Abramson/ProgressReport

This report was produced by the University of Pennsylvania Health System 3600 Market Street, Suite 210 Philadelphia, PA 19104

If you'd like to receive a printed copy of this report, call 215.573.2480 or email [email protected].

Visit PennMedicine.org/Cancer to find a doctor or learn more about the latest research and clinical trials happening now at the Abramson Cancer Center.

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