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Job Description Margaret Turner Warwick Chair of Thoracic Medicine Job Description Margaret Turner Warwick Chair of Thoracic Medicine National Heart and Lung Institute (NHLI) Faculty of Medicine 1. The Post Title of Post: Margaret Turner Warwick Chair of Thoracic Medicine Institute: National Heart and Lung Institute Main site of activity: Hammersmith and White City Campuses Responsible to: Head of the NHLI, Professor Edwin Chilvers Accountable to: Head of Section of Inflammation, Repair and Development, Professor Sejal Seglani Salary range: Clinical Academics: £79,860 to £107,668 per annum, dependent on level of seniority plus £2,162 London Allowance per annum (Clinical Academics) Academics: minimum starting salary of £79,080 per annum Working hours. Full time of 35 hours for non-clinicians and 40 hours for clinicians (Total of 10 PAs of 4 hours each) Job Family / Level: Clinical Academic or Academic Job Family Contract type: Open Ended, full time 2. Background of the post In line with the new NHLI Strategic Research Plan (2019-2024) and the desire of the College to consolidate its respiratory science into a new £120M building located alongside our existing Cardiology and Vascular Laboratories on the Hammersmith & White City Campuses, we now wish to appoint a world-leading clinical or non-clinical scientist to the Margaret Turner Warwick Chair of Thoracic Medicine. This individual will also build and lead the MTW Centre for Fibrosing Lung Disease. The ‘Margaret Turner Warwick Chair of Thoracic Medicine’ sits within the National Heart and Lung Institute (NHLI) and is one of the Departments and Colleges most prestigious and senior Chairs. The post was previously held with distinction by Professor Peter Barnes FMedSci, FRS and recognizes the major contribution to Respiratory Medicine of 1 Professor Dame Margaret Turner Warwick DBE FMedSci. Dame Margaret was a former Dean of the Cardiothoracic Institute (the forerunner of the NHLI), the first female President of the Royal College of Physicians and a world-leading clinical scientist with a specialist interest in asthma and lung fibrosis. The NHLI, in recognition of Professor Turner Warwick’s contributions, has therefore decided to establish a new Margaret Turner Warwick Centre (MTW) for Fibrosing Lung Disease. The MTW Centre in Fibrosing Lung Disease represents a partnership between academic staff within NHLI and the many interstitial lung disease (ILD) clinicians working in the Imperial Academic Health Science Centre (AHSC) – Imperial College Healthcare NHS Trust (St Mary’s and Hammersmith Hospital), Royal Brompton and Harefield Hospital NHS Trust, Royal Marsden Hospital and Chelsea Westminster Hospital NHS Trust. The purpose of the MTW Centre is to increase fundamental knowledge of the basic biology of fibrosis as the necessary basis for the development, evaluation and introduction into clinical practice of novel safe effective treatments for fibrosing lung disease. The post- holder will be expected to drive the development and establishment of the Centre as a world leading centre of excellence in the study of tissue fibrosis. NHLI has a long-established reputation in translational and clinical research in pulmonary fibrosis. This condition typified by idiopathic pulmonary fibrosis (IPF) is an important and growing cause of respiratory disability and premature death. The recent introduction of new treatments has shown for the first time that this disease is tractable however the prognosis remains poor with a median survival of 3 years from diagnosis, worse than for several cancers. Current research within the NHLI has a focus on immune-matrix cell interactions (Clare Lloyd/Rob Snelgrove), alveolar macrophage biology (Adam Byrne), lung microbiome alterations in IPF (Phil Molyneaux), lung slice and lung-on-chip modelling (Clare Lloyd/Charlotte Dean), novel biomarkers and clinical trials (Toby Maher/Phil Molyneaux) and AI-driven imaging analysis (Simon Walsh). The Principal Investigators working on lung fibrosis are based on the South Kensington campus and are part of the ‘Inflammation, Repair and Development Section’ headed by Professor Sejal Saglani, which sits within the overall Respiratory Division of the NHLI (Leads Professors Wedzicha and Lloyd). One of the special opportunities available to these scientists is the close relationship with the ILD clinical teams based at the Brompton Hospital, St Mary’s and the Hammersmith Hospital. These teams also have an exceptionally active research programme (Athol Wells/Phil Molyneaux/Pete George) and together these hospitals have ten specialist ILD consultants and see 1,200 new patients with interstitial lung disease each year. They are fully supported by specialist Radiology, interventional bronchoscopy, thoracic surgery, pulmonary rehabilitation, transplantation, Occupational Medicine, Pharmacy and Nurse teams. Patients are actively engaged in research with more than 1,000 patients recruited into prospective studies and clinical trials in the past 8 years. The MTW Centre will build on these strong foundations and further develop fundamental research in fibrosis. The support available for this appointment includes full laboratory and dry-lab provision including core support for microscopy, flow-cytometry, in vivo programmes and state of the art animal and human imaging platforms and the support of a 0.5 FTE (full time equivalent) personal assistant. Charitable funding has been raised to support two non- 2 clinical academic posts for five years, a senior lecturer and a lecturer. The MTW Centre is also a priority for Imperial College’s fund-raising department ‘Advancement’, which has a target of continuing to fund raise to a sum of £5 million. NHLI together with its partner Trusts is a recognized international leader in translational research in interstitial lung disease. The successful appointee will have demonstrated excellence in fibrosis research not necessarily restricted to the lungs, , the capacity to lead an academic multidisciplinary team and to create impact through collaboration with commercial and non-commercial partners as well as contribute to fund raising for the Centre. All College staff have a strong commitment to undergraduate and postgraduate education and will be expected to contribute fully to our Educational programmes and College life. The NHLI is strongly committed to enhancing diversity, in all its forms, and supporting, developing and valuing its staff as laid out in the ‘Imperial Expectations’ document. A clinical appointment will have the option to hold clinical sessions at Royal Brompton and Imperial College Healthcare NHS Trust Hospitals. 3. National Heart and Lung Institute The NHLI is one of the biggest Departments within the Faculty of Medicine at Imperial College London. The College is a world top-ten University and the UKs leading STEMM (Science-Technology-Engineering-Maths-Medicine) University. It was top ranked in Respiratory medicine and Cardiovascular Sciences in the UK Government’s latest ‘Research Excellence Framework’ (REF) exercise. The NHLI has over 100 Principal Investigators (135 individuals returned in the REF2021 exercise) and 500 staff and is committed to developing new treatments and cures for heart, lung and vascular diseases. This group of diseases continue to kill 1 in 2 people in the UK and worldwide. Its scientists hold over £170M in active grants and the Department hosts a number of UK Centres of Excellence including an Asthma-UK Centre, BHF Centre for Research Excellence, BHF Cardiovascular Regenerative Medicine Centre and the National centre for Mesothelioma Research as well as three Strategic Cystic Fibrosis Trust Research Centres and the Asmarley Centre for Genomic Medicine. Its staff also lead several the Colleges’ cross-faculty Networks and Centres of Excellence and play a major role in Undergraduate teaching of Medical and Biomedical Students. The NHLI runs 5 taught-course MSc Programmes: https://www.imperial.ac.uk/nhli/study/postgraduate-taught/ and has over 100 MSc students and 150 registered PhD students: https://www.imperial.ac.uk/nhli/study/postgraduate-research/. Over 20 of its staff are Fellows of the Academy of Medical Sciences. The NHLI undertakes world-leading research in: • Vascular, myocardial and lung cell biology • Lung immunology, allergy and infection • Cardiac electrophysiology • Advanced therapies (genes, drugs, stem cells and devices) 3 • Population health (environmental and occupational causes of heart, lung and vascular disease) • Disease progression (early disease, repair, ageing and fibrosis) • Genomics, imaging, big-data and AI • Clinical trials (patient cohorts, volunteer studies, bioresources and trial design) Membership: Margaret Turner Warwick Centre for Fibrosing Lung Disease NHLI, Imperial College London/Imperial Academic Health Science Centre Head of Centre: # MTW Professor of Thoracic Medicine [this post] PA: Ms Eunice Haining - [email protected] Administrator: Mr Richard Mattin – [email protected] Academic staff: # Professor Edwin Chilvers - [email protected] # Professor Clare Lloyd - [email protected] # Professor Sejal Saglani - [email protected] Professor Toby Maher - [email protected] Dr Phil Molyneaux - [email protected] Dr Adam Byrne - [email protected] # Professor Anthony Newman Taylor - [email protected] # Professor Jadwiga Wedzicha - [email protected] Dr Rob Snelgrove - [email protected] Dr Simon Walsh – [email protected] Non-clinical Senior Lecturer [TBA] Non-clinical Lecturer [TBA] ILD Physicians: # Dr Pete
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