J. Microbiol. Biotechnol. (2013), 23(11), 1–3 https://doi.org/10.4014/jmb.1702.02021 jmb

Fig. S1. Growth of the ancestral and evolved E. coli in LB medium with different concentration of butanol (added to the medium at the beginning). The error bar denotes the standard error of the mean from three independent growth curves.

Fig. S2. Functional association network of genes associated with the point mutations.

Circles denote genes that were colored proportional to the log2-transformed transcript ratio of E1/A1. Lines between the genes indicate the functional associations, with their width being proportional to their weight. The color and size of the circles were scaled based on the mRNA levels; Green and red color means higher transcript level in the ancestral and evolved strain, respectively. 2 Name et al.

Fig. S3. Phenotype microarray comparison of ancestral and evolved E. coli strains. The growth curves are colored yellow for a similar growth of the strains; green, for a faster growth of ancestral strains; and red, for a faster growth of the evolved strains. The PM plates (Biolog Inc.) consist of twenty 96-well microplates containing different sources of carbon (PM1 and PM2), (PM3), phosphorus and sulphur (PM4), auxotrophic supplement (PM5 to PM8), salt (PM9), pH stress (PM10), and inhibitory compounds such as antibiotics, antimetabolites, and other inhibitors (PM11 to PM20). The flagged wells had cell growths showing large differences in the area under curve (AUC) of the two strains. Detailed information regarding the PM tests can be found at www.biolog.com.

J. Microbiol. Biotechnol. Supplementary Table S1. Transcript ratios from the microarray tests. Genes associated with point mutations are in bold (FDR < 0.05).

Locus in E. Log2 (transcript ratio) Locus in E. COG coli K-12 Name COG class FDR coli C description MG1655 A1/A0 E1/E0 E0/A0 E1/A1 EcolC_0001 b3702 dnaA chromosomal replication initiator protein INFORMATION Replication, 0.47 0.41 0.29 0.23 0.192 DnaA, DNA-binding transcriptional dual STORAGE AND recombination regulator PROCESSING and repair EcolC_0003 b3700 recF gap repair protein INFORMATION Replication, 0.51 0.62 0.56 0.67 0.555 STORAGE AND recombination PROCESSING and repair EcolC_0004 b3699 gyrB DNA gyrase, subunit B INFORMATION Replication, 0.88 0.86 0.32 0.30 0.899 STORAGE AND recombination PROCESSING and repair EcolC_0005 b3698 yidB conserved protein, DUF937 family POORLY Function 0.00 -0.08 0.27 0.19 0.282 CHARACTERIZ unknown ED EcolC_0006 b3697 yidA sugar phosphate ; substrates POORLY General 0.15 0.48 0.22 0.55 0.738 include erythrose 4-P and mannose 1-P CHARACTERIZ function phosphatase ED prediction EcolC_0007 b3696 yidX predicted lipoproteinC - -l -0.09 0.06 0.11 0.26 0.273 EcolC_0008 b4479 dgoR predicted DNA-binding transcriptional INFORMATION Transcription 0.83 0.50 0.18 -0.15 0.566 regulator STORAGE AND PROCESSING EcolC_0009 b3693 dgoK 2-oxo-3-deoxygalactonate METABOLISM Carbohydrate 0.56 0.32 0.10 -0.15 0.015 transport and metabolism EcolC_0010 b4477 dgoA 2-oxo-3-deoxygalactonate 6-phosphate METABOLISM Carbohydrate 0.29 0.10 0.04 -0.16 0.784 aldolase transport and metabolism EcolC_0011 b4478 dgoD galactonate dehydratase CELLULAR Cell 0.62 0.37 0.27 0.02 0.152 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0012 b3691 dgoT D-galactonate transporter METABOLISM Carbohydrate -0.14 -0.17 0.01 -0.02 0.821 transport and metabolism EcolC_0014 b3689 yidR conserved protein CELLULAR Intracellular 0.13 0.11 0.32 0.30 0.830 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0015 b3688 yidQ conserved outer membrane protein POORLY General -0.14 -0.16 0.10 0.08 0.863 CHARACTERIZ function ED prediction EcolC_0016 b3687 ibpA heat shock chaperone CELLULAR Posttranslatiol -0.06 0.04 -0.22 -0.12 0.923 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0017 b3686 ibpB heat shock chaperone CELLULAR Posttranslatio 0.07 0.25 0.10 0.27 0.690 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0018 b3685 yidE predicted transporter POORLY General -0.27 -0.09 0.17 0.35 0.251 CHARACTERIZ function ED prediction l EcolC_0019 b3684 yidP predicted DNA-binding transcriptional INFORMATION Transcription -0.11 -0.02 0.08 0.17 0.750 regulator STORAGE AND PROCESSING EcolC_0020 b3683 glvC - - - -0.02 0.18 0.13 0.33 0.116 EcolC_0021 b4556 glvG - - - 0.15 -0.01 0.35 0.20 0.625 EcolC_0024 b3676 yidH inner membrane protein, DUF202 family POORLY Function -0.21 0.07 0.22 0.49 0.415 CHARACTERIZ unknown ED EcolC_0025 b3675 yidG inner membrane protein - - -0.19 -0.13 0.01 0.07 0.571 EcolC_0026 b3674 yidF predicted DNA-binding transcriptional POORLY General 0.37 0.79 0.34 0.76 0.457 regulator CHARACTERIZ function ED prediction EcolC_0027 b3673 emrD multidrug efflux system protein METABOLISM Carbohydratel 0.02 0.16 0.32 0.46 0.429 transport and metabolism EcolC_0028 b3671 ilvB acetolactate synthase I, large subunit METABOLISM Amino acid -0.10 -0.01 0.13 0.22 0.843 transport and metabolism EcolC_0029 b3670 ilvN acetolactate synthase I, small subunit METABOLISM Amino acid 0.19 0.08 0.34 0.23 0.191 transport and metabolism EcolC_0030 b3669 uhpA DNA-binding response regulator in two- CELLULAR Signal 0.06 -0.03 0.17 0.07 0.381 component regulatory system wtih UhpB PROCESSES transduction AND mechanisms SIGNALING EcolC_0031 b3668 uhpB sensory in two-component CELLULAR Signal -0.09 -0.24 0.08 -0.07 0.591 regulatory sytem with UhpA PROCESSES transduction AND mechanisms SIGNALING EcolC_0032 b3667 uhpC membrane protein regulates uhpT METABOLISM Carbohydrate 0.08 0.21 -0.03 0.10 0.817 expression transport and metabolism EcolC_0033 b3666 uhpT hexose phosphate transporter METABOLISM Carbohydrate 2.48 0.76 0.04 -1.69 0.004 transport and metabolism EcolC_0034 b3665 ade cryptic adenine deaminase METABOLISM Nucleotide 0.63 0.18 0.18 -0.27 0.112 transport and metabolism EcolC_0035 b3664 yicO putative adenine permease POORLY General -0.03 0.09 0.05 0.18 0.386 CHARACTERIZ function ED prediction EcolC_0036 b3663 yicN conserved protein - -l 0.17 0.34 0.41 0.58 0.030 EcolC_0037 b3662 nepI predicted transporter METABOLISM Carbohydrate -0.23 -0.14 0.00 0.09 0.961 transport and metabolism EcolC_0038 b4555 yicS predicted periplasmic protein - - -0.06 0.00 0.36 0.42 0.820 EcolC_0039 b3661 nlpA cytoplasmic membrane lipoprotein-28 METABOLISM Inorganic ion 0.14 0.05 0.40 0.31 0.600 transport and metabolism EcolC_0040 b3660 yicL predicted inner membrane protein - - -0.25 -0.27 -0.16 -0.18 0.899 EcolC_0041 b3659 setC putative arabinose efflux transporter METABOLISM Carbohydrate -0.15 -0.21 -0.07 -0.13 0.918 transport and metabolism EcolC_0054 b3657 yicJ predicted transporter METABOLISM Carbohydrate -0.24 -0.51 -0.29 -0.56 0.140 transport and metabolism EcolC_0055 b3656 yicI predicted alpha-glucosidase METABOLISM Carbohydrate 0.32 0.25 0.38 0.31 0.810 transport and metabolism EcolC_0056 b3655 yicH conserved protein - - 0.01 -0.04 0.27 0.22 0.810 EcolC_0057 b3654 xanP xanthine permease METABOLISM Nucleotide -0.11 -0.17 -0.04 -0.10 0.685 transport and metabolism EcolC_0058 b3653 gltS glutamate transporter METABOLISM Amino acid 0.11 0.41 0.37 0.67 0.289 transport and metabolism EcolC_0059 b3652 recG ATP-dependent DNA INFORMATION Replication, 0.17 0.36 0.37 0.55 0.145 STORAGE AND recombination PROCESSING and repair EcolC_0060 b3651 trmH tRNA mG18-2'-O-methyltransferase, SAM- INFORMATION Translation, 0.25 0.49 0.18 0.42 0.640 dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0061 b3650 spoT bifunctional (p)ppGpp synthetase II/ CELLULAR Signal 0.34 0.62 0.24 0.52 0.017 guanosine-3',5'-bis pyrophosphate 3'- PROCESSES transduction pyrophosphohydrolase AND mechanisms SIGNALING EcolC_0062 b3649 rpoZ RNA , omega subunit INFORMATION Transcription -0.42 0.04 0.06 0.53 0.012 STORAGE AND PROCESSING EcolC_0063 b3648 gmk METABOLISM Nucleotide -0.24 -0.23 0.17 0.18 0.962 transport and metabolism EcolC_0064 b3647 ligB DNA , NAD(+)-dependent INFORMATION Replication, 0.06 0.18 0.17 0.28 0.338 STORAGE AND recombination PROCESSING and repair EcolC_0065 b3646 yicG inner membrane protein, UPF0126 family POORLY Function -0.04 0.04 0.28 0.35 0.446 CHARACTERIZ unknown ED EcolC_0066 b3645 dinD DNA-damage-inducible protein - - 0.26 0.75 -0.23 0.26 0.047 EcolC_0067 b3644 yicC conserved protein, UPF0701 family POORLY Function 0.09 -0.03 0.04 -0.08 0.152 CHARACTERIZ unknown ED EcolC_0068 b3643 rph - - - -0.24 0.24 0.29 0.77 0.081 EcolC_0069 b3642 pyrE orotate phosphoribosyltransferase METABOLISM Nucleotide 0.14 0.15 0.24 0.25 0.882 transport and metabolism EcolC_0070 b3641 slmA DNA-binding anti-FtsZ division inhibitor INFORMATION Transcription -0.06 0.00 0.05 0.11 0.952 STORAGE AND PROCESSING EcolC_0071 b3640 dut deoxyuridinetriphosphatase METABOLISM Nucleotide 0.26 0.20 0.07 0.01 0.758 transport and metabolism EcolC_0072 b3639 dfp fused 4'-phosphopantothenoylcysteine METABOLISM Coenzyme 0.40 0.56 0.39 0.55 0.399 decarboxylase/phosphopantothenoylcystein transport and e synthetase, FMN-binding metabolism EcolC_0073 b3638 yicR conserved protein, UPF0758 family INFORMATION Replication, 0.05 0.03 0.00 -0.02 0.733 STORAGE AND recombination PROCESSING and repair EcolC_0074 b3637 rpmB 50S ribosomal subunit protein L28 INFORMATION Translation, -0.31 -0.12 0.14 0.33 0.631 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0075 b3636 rpmG 50S ribosomal subunit protein L33 INFORMATION Translation, -0.60 -0.47 -0.16 -0.03 0.433 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0076 b3635 mutM formamidopyrimidine/5-formyluracil/ 5- INFORMATION Replication, -0.03 0.01 0.24 0.28 0.609 hydroxymethyluracil DNA glycosylase STORAGE AND recombination PROCESSING and repair EcolC_0077 b3634 coaD pantetheine-phosphate adenylyltransferase METABOLISM Coenzyme 0.03 0.21 0.20 0.37 0.265 transport and metabolism EcolC_0078 b3633 waaA 3-deoxy-D-manno-octulosonic-acid CELLULAR Cell 0.17 0.07 0.29 0.20 0.505 (KDO transferase) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0079 - waaQ lipopolysaccharide core biosynthesis CELLULAR Cell -0.32 -0.11 0.05 0.26 0.227 protein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0080 - waaG glucosyltransferase I CELLULAR Cell -0.26 0.14 -0.05 0.34 0.018 PROCESSES wall/membra AND ne/envelope SIGNALING biogenesis EcolC_0083 - waaO UDP-glucose:(Glucosyl) LPS alpha1,3- CELLULAR Cell -0.76 -0.64 0.11 0.23 0.526 glucosyltransferase WaaO PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0084 - waaY lipopolysaccharide core biosynthesis CELLULAR Signal -0.20 -0.25 0.54 0.48 0.899 protein PROCESSES transduction AND mechanisms SIGNALING EcolC_0085 - waaW UDP-galactose:(Galactosyl) LPS alpha1,2- CELLULAR Cell -0.26 -0.30 0.42 0.37 0.733 galactosyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0087 - waaL Lipid A-core, surface polymer ligase - - -0.05 0.04 0.40 0.49 0.508 EcolC_0088 - waaC ADP-heptose:LPS heptosyl transferase I CELLULAR Cell -0.18 -0.17 0.49 0.50 0.857 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0089 b3620 waaF ADP-heptose:LPS heptosyltransferase II CELLULAR Cell -0.35 -0.32 0.01 0.04 0.602 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0090 b3619 hldD ADP-L-glycero-D-mannoheptose-6- CELLULAR Cell -0.47 -0.46 0.09 0.10 0.746 epimerase, NAD(P)-binding PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0091 b3617 kbl glycine C-acetyltransferase METABOLISM Coenzyme -0.03 -0.38 -0.37 -0.72 0.026 transport and metabolism EcolC_0092 b3616 tdh threonine 3-dehydrogenase, NAD(P)- METABOLISM Amino acid -0.30 -0.37 -0.24 -0.31 0.943 binding transport and metabolism EcolC_0093 b3615 waaH LPS(HepIII)-glucuronic acid CELLULAR Cell -0.16 -0.01 -0.06 0.09 0.395 glycosyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0094 b3614 yibQ predicted polysaccharide deacetylase POORLY Function 0.00 -0.01 0.06 0.04 0.906 CHARACTERIZ unknown ED EcolC_0096 b3612 gpmM phosphoglycero mutase III, - METABOLISM Carbohydrate -1.28 -0.26 0.21 1.23 0.005 independent transport and metabolism EcolC_0097 b3611 yibN predicted rhodanese-related METABOLISM Inorganic ion -0.80 -0.39 -0.03 0.38 0.092 sulfurtransferase transport and metabolism EcolC_0098 b3610 grxC glutaredoxin 3 CELLULAR Posttranslatio -0.92 -1.61 0.05 -0.65 0.015 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0099 b3609 secB protein export chaperone CELLULAR Intracellular -0.67 -0.54 -0.04 0.09 0.912 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0100 b3608 gpsA glycerol-3-phosphate dehydrogenase METABOLISM Energy -0.27 -0.20 0.02 0.09 0.469 (NAD+) production and conversion EcolC_0101 b3607 cysE serine acetyltransferase METABOLISM Amino acid 0.18 0.30 -0.01 0.12 0.120 transport and metabolism EcolC_0102 b3606 trmL tRNA Leu mC34,mU34 2'-O- INFORMATION Translation, 0.02 0.28 0.24 0.50 0.708 methyltransferase, SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0103 b3605 lldD L-lactate dehydrogenase, FMN-linked METABOLISM Energy 0.02 -0.04 0.22 0.15 0.810 production and conversion EcolC_0104 b3604 lldR dual role activator/repressor for lldPRD INFORMATION Transcription -0.06 -0.24 0.16 -0.02 0.254 operon STORAGE AND PROCESSING EcolC_0105 b3603 lldP L-lactate permease METABOLISM Energy -0.16 -0.18 0.06 0.04 0.599 production and conversion EcolC_0108 - - hypothetical protein - - 0.03 -0.06 0.10 0.00 0.549 EcolC_0109 b3602 yibL conserved protein, ribosome-associated - - 0.00 0.16 0.14 0.29 0.996 EcolC_0110 b4554 yibT predicted protein - - 1.39 -0.25 -1.05 -2.68 0.009 EcolC_0111 b3601 mtlR mannitol operon repressor INFORMATION Transcription 1.51 -0.13 -0.16 -1.80 0.018 STORAGE AND PROCESSING EcolC_0112 b3600 mtlD mannitol-1-phosphate dehydrogenase, METABOLISM Carbohydrate -0.21 -0.38 0.34 0.17 0.175 NAD-dependent transport and metabolism EcolC_0113 b3599 mtlA fused mannitol-specific PTS : IIA METABOLISM Carbohydrate 0.13 -0.13 0.55 0.29 0.269 components/IIB components/IIC transport and components metabolism EcolC_0114 b3598 yibI inner membrane protein, DUF3302 family - - -0.46 -0.35 -0.11 0.00 0.655 EcolC_0115 b3597 yibH predicted protein CELLULAR Defense 0.16 0.24 0.24 0.32 0.577 PROCESSES mechanisms AND SIGNALING EcolC_0117 b3596 yibG conserved protein POORLY General -0.06 -0.23 -0.11 -0.28 0.181 CHARACTERIZ function ED prediction EcolC_0118 b3595 yibJ - - -l 0.25 0.27 0.37 0.39 0.850 EcolC_0119 b3594 yibA predicted containing HEAT-repeat METABOLISM Energy 0.39 0.27 0.07 -0.05 0.098 production and conversion EcolC_0119 b4552 yrhC - - - 0.42 0.52 0.55 0.65 0.907 EcolC_0121 b3592 yibF glutathione S-transferase homolog CELLULAR Posttranslatio 0.15 0.03 0.33 0.20 0.795 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0122 b3591 selA selenocysteine synthase METABOLISM Amino acid -0.42 0.01 0.17 0.59 0.028 transport and metabolism EcolC_0123 b3590 selB selenocysteinyl-tRNA-specific translation INFORMATION Translation, -0.30 -0.02 0.21 0.49 0.011 factor STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0124 b3589 yiaY predicted Fe-containing alcohol METABOLISM Energy -0.09 0.10 0.14 0.33 0.532 dehydrogenase, Pfam00465 family production and conversion EcolC_0125 b3588 aldB aldehyde dehydrogenase B METABOLISM Energy 0.03 0.29 -0.34 -0.09 0.167 production and conversion EcolC_0126 b3587 yiaW inner membrane protein, DUF3302 family - - -0.45 -0.53 -0.42 -0.50 0.902 EcolC_0127 b3586 yiaV membrane fusion protein (MFP) CELLULAR Defense -0.36 -0.36 -0.24 -0.24 0.865 component of efflux pump, signal anchor PROCESSES mechanisms AND SIGNALING EcolC_0128 b3585 yiaU predicted DNA-binding transcriptional INFORMATION Transcription 0.25 0.30 0.27 0.32 0.494 regulator STORAGE AND PROCESSING EcolC_0129 b3584 yiaT predicted outer membrane protein CELLULAR Cell 0.02 -0.10 -0.11 -0.23 0.681 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0131 b3583 yiaS L-ribulose-5-phosphate 4-epimerase METABOLISM Carbohydrate -0.01 -0.11 0.16 0.06 0.204 transport and metabolism EcolC_0132 b3582 yiaR predicted L-xylulose 5-phosphate 3- METABOLISM Carbohydrate -0.12 -0.09 -0.15 -0.13 0.961 epimerase transport and metabolism EcolC_0133 b3581 yiaQ 3-keto-L-gulonate 6-phosphate METABOLISM Carbohydrate 0.60 0.62 0.41 0.43 0.484 decarboxylase transport and metabolism EcolC_0134 b3580 lyxK L-xylulose kinase METABOLISM Carbohydrate 0.03 -0.06 -0.02 -0.11 0.398 transport and metabolism EcolC_0135 b3579 yiaO L-dehydroascorbate transporter, METABOLISM Carbohydrate 0.00 0.00 0.04 0.04 0.523 periplasmic binding protein for TRAP transport and (TRipartite ATP-independent Periplasmic) metabolism family transporter YiaMNO EcolC_0136 b3578 yiaN L-dehydroascorbate transporter, TRAP METABOLISM Carbohydrate -0.01 -0.07 0.00 -0.07 0.887 permease large subunit for TRAP transport and (TRipartite ATP-independent Periplasmic) metabolism family transporter YiaMNO EcolC_0138 b3576 yiaL conserved protein METABOLISM Carbohydrate 0.08 -0.01 -0.14 -0.22 0.716 transport and metabolism EcolC_0139 b3575 yiaK 2,3-diketo-L-gulonate reductase, NADH- METABOLISM Energy 0.08 -0.04 0.14 0.02 0.366 dependent production and conversion EcolC_0140 b3574 yiaJ DNA-binding transcriptional repressor of INFORMATION Transcription -0.05 0.18 0.09 0.33 0.518 yiaK-S operon STORAGE AND PROCESSING EcolC_0141 b3573 ysaA predicted hydrogenase, 4Fe-4S ferredoxin- METABOLISM Energy -0.76 -0.19 0.02 0.59 0.045 type component production and conversion EcolC_0142 b3572 avtA valine-pyruvate aminotransferase 1 METABOLISM Amino acid 0.33 0.53 0.14 0.34 0.678 transport and metabolism EcolC_0143 b3571 malS alpha-amylase METABOLISM Carbohydrate 0.24 0.54 0.07 0.37 0.385 transport and metabolism EcolC_0144 b3570 bax conserved protein POORLY General 0.42 0.04 0.19 -0.18 0.120 CHARACTERIZ function ED prediction EcolC_0145 b3569 xylR DNA-binding transcriptional activator, INFORMATION Transcriptionl 0.42 0.41 0.33 0.32 0.510 xylose-binding STORAGE AND PROCESSING EcolC_0146 b3568 xylH D-xylose ABC transporter permease METABOLISM Carbohydrate 0.29 0.31 0.13 0.15 0.931 subunit transport and metabolism EcolC_0147 b3567 xylG fused D-xylose transporter subunits of METABOLISM Carbohydrate 0.87 0.84 0.27 0.24 0.937 ABC superfamily: ATP-binding transport and components metabolism EcolC_0148 b3566 xylF D-xylose transporter subunit METABOLISM Carbohydrate 1.30 1.33 0.15 0.18 0.937 transport and metabolism EcolC_0149 b3565 xylA D-xylose METABOLISM Carbohydrate 0.35 0.39 -0.18 -0.14 0.877 transport and metabolism EcolC_0150 b3564 xylB xylulokinase METABOLISM Carbohydrate 0.32 0.94 0.12 0.73 0.331 transport and metabolism EcolC_0151 b3563 yiaB inner membrane protein, YiaAB family POORLY Function -0.26 -0.08 -0.10 0.08 0.628 CHARACTERIZ unknown ED EcolC_0152 b3562 yiaA inner membrane protein, YiaAB family POORLY Function -0.64 -0.61 -0.38 -0.34 0.834 CHARACTERIZ unknown ED EcolC_0153 b3561 wecH O-acetyltransferase for enterobacterial POORLY Function -0.24 -0.12 -0.20 -0.07 0.934 common antigen (ECA) CHARACTERIZ unknown ED EcolC_0154 b4553 ysaB predicted protein - - -0.11 -0.11 0.12 0.11 0.990 EcolC_0155 b3560 glyQ glycine tRNA synthetase, alpha subunit INFORMATION Translation, -0.21 0.09 -0.22 0.09 0.135 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0156 b3559 glyS glycine tRNA synthetase, beta subunit INFORMATION Translation, 0.21 0.28 -0.30 -0.23 0.471 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0159 b4455 hokA toxic polypeptide, small - - -0.47 -0.35 -0.15 -0.03 0.801 EcolC_0160 b3556 cspA RNA chaperone and anti-terminator, cold- INFORMATION Transcription 0.61 0.05 0.08 -0.48 0.018 inducible STORAGE AND PROCESSING EcolC_0161 b3555 yiaG predicted transcriptional regulator, INFORMATION Transcription -0.55 -0.76 0.26 0.05 0.444 HTH_CROC1 family STORAGE AND PROCESSING EcolC_0162 b3554 yiaF conserved protein - - -0.22 -0.27 0.22 0.18 0.517 EcolC_0163 b3553 ghrB glyoxylate/hydroxypyruvate reductase B METABOLISM Energy -0.03 -0.17 0.06 -0.08 0.369 production and conversion EcolC_0164 b3552 yiaD multicopy suppressor of bamB; outer CELLULAR Cell 0.18 0.11 0.26 0.19 0.733 membrane lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0165 b3551 bisC biotin sulfoxide reductase METABOLISM Energy 0.11 0.10 -0.14 -0.15 0.623 production and conversion EcolC_0166 b3550 yiaC predicted acyltransferase with acyl-CoA N- METABOLISM Amino acid 0.07 -0.17 0.00 -0.24 0.475 acyltransferase domain transport and metabolism EcolC_0167 b3549 tag 3-methyl-adenine DNA glycosylase I, INFORMATION Replication, -0.19 -0.17 -0.06 -0.03 0.780 constitutive STORAGE AND recombination PROCESSING and repair EcolC_0168 b3548 yhjY conserved protein CELLULAR Cell motility -0.46 -0.25 0.36 0.57 0.930 PROCESSES AND SIGNALING EcolC_0169 b3547 yhjX pyruvate-inducible inner membrane METABOLISM Inorganic ion 0.02 0.25 0.21 0.44 0.212 protein, putative transporter transport and metabolism EcolC_0170 b3546 eptB KDO phosphoethanolamine transferase, POORLY General 0.47 0.24 -0.15 -0.38 0.541 Ca(2+)-inducible CHARACTERIZ function ED prediction EcolC_0171 b3544 dppA dipeptide transporter METABOLISM Aminol acid 0.43 -1.14 0.15 -1.42 0.003 transport and metabolism EcolC_0172 b3543 dppB dipeptide/heme transporter METABOLISM Amino acid 0.52 -0.24 -0.22 -0.98 0.007 transport and metabolism EcolC_0173 b3542 dppC dipeptide/heme transporter METABOLISM Amino acid 0.56 0.56 0.19 0.20 0.906 transport and metabolism EcolC_0174 b3541 dppD dipeptide/heme transporter METABOLISM Amino acid 0.18 0.13 0.03 -0.02 0.374 transport and metabolism EcolC_0175 b3540 dppF dipeptide transporter METABOLISM Amino acid 0.13 0.12 0.08 0.06 0.561 transport and metabolism EcolC_0176 b3539 yhjV predicted transporter METABOLISM Amino acid -0.25 -0.28 0.17 0.14 0.648 transport and metabolism EcolC_0177 b4453 ldrD toxic polypeptide, small - - 0.00 -0.13 0.08 -0.05 0.455 EcolC_0177 - ldrE toxic polypeptide, small - - 0.11 0.08 0.11 0.08 0.944 EcolC_0178 b3538 bcsG inner membrane protein, predicted - - 0.05 -0.02 0.10 0.04 0.343 endoglucanase, DUF3260 family EcolC_0179 b3537 bcsF predicted protein - - -0.14 -0.07 0.13 0.20 0.653 EcolC_0180 b3536 bcsE cellulose production protein - - 0.25 0.30 0.36 0.40 0.826 EcolC_0182 b3535 yhjR putative protein - - -0.79 -1.24 0.58 0.13 0.035 EcolC_0183 b3534 bcsQ - - - 0.21 0.19 0.20 0.18 0.751 EcolC_0184 b3533 bcsA cellulose synthase, catalytic subunit CELLULAR Cell 0.09 0.02 0.41 0.34 0.690 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0185 b3532 bcsB regulator of cellulose synthase, cyclic di- - - 0.09 -0.11 0.41 0.20 0.168 GMP binding EcolC_0186 b3531 bcsZ endo-1,4-D-glucanase METABOLISM Carbohydrate -0.15 -0.62 0.13 -0.34 0.026 transport and metabolism EcolC_0187 b3530 bcsC cellulose synthase subunit CELLULAR Intracellular 0.12 -0.16 0.49 0.20 0.198 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0188 b3529 yhjK cyclic-di-GMP CELLULAR Signal 0.24 0.11 0.22 0.08 0.621 PROCESSES transduction AND mechanisms SIGNALING EcolC_0189 b3528 dctA C4-dicarboxylic acid, orotate and citrate METABOLISM Energy 2.05 -0.16 -0.21 -2.42 0.000 transporter production and conversion EcolC_0190 b3527 yhjJ predicted zinc-dependent peptidase POORLY General 0.45 0.30 0.09 -0.07 0.234 CHARACTERIZ function ED prediction EcolC_0191 b3526 kdgK ketodeoxygluconokinase METABOLISM Carbohydratel 0.44 0.60 0.25 0.41 0.600 transport and metabolism EcolC_0192 b3525 yhjH cyclic-di-GMP phosphodiesterase, FlhDC- CELLULAR Signal 0.09 0.26 0.23 0.40 0.357 regulated PROCESSES transduction AND mechanisms SIGNALING EcolC_0193 b3524 yhjG Inner membrane protein, AsmA family CELLULAR Cell -0.08 -0.01 0.15 0.23 0.702 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0194 b3523 yhjE inner membrane protein, predicted METABOLISM Carbohydrate 0.15 0.05 0.36 0.26 0.556 transporter transport and metabolism EcolC_0195 b3522 yhjD putative alternate lipid exporter, suppressor POORLY Function 0.30 0.09 0.38 0.16 0.055 of msbA and KDO essentiality, inner CHARACTERIZ unknown membrane protein ED EcolC_0196 b3521 yhjC predicted DNA-binding transcriptional INFORMATION Transcription 0.26 0.07 0.13 -0.06 0.413 regulator STORAGE AND PROCESSING EcolC_0197 b3520 yhjB predicted two-component system response CELLULAR Signal 0.05 0.12 0.17 0.24 0.620 regulator, LuxR-like HTH domain, PROCESSES transduction function unknown AND mechanisms SIGNALING EcolC_0198 b3519 treF cytoplasmic trehalase METABOLISM Carbohydrate 0.12 0.26 0.28 0.42 0.503 transport and metabolism EcolC_0199 b3518 yhjA predicted cytochrome C peroxidase METABOLISM Inorganic ion -0.76 -0.35 0.00 0.40 0.145 transport and metabolism EcolC_0200 b3517 gadA glutamate decarboxylase A, PLP-dependent METABOLISM Amino acid -0.90 -0.80 0.21 0.30 0.851 transport and metabolism EcolC_0201 b3516 gadX DNA-binding transcriptional dual regulator INFORMATION Transcription -0.24 -1.03 1.13 0.34 0.015 STORAGE AND PROCESSING EcolC_0202 b3515 gadW transcriptional activator of gadA and INFORMATION Transcription 0.14 -0.32 0.74 0.27 0.167 gadBC; repressor of gadX STORAGE AND PROCESSING EcolC_0203 b3514 mdtF anaerobic multidrug efflux transporter, CELLULAR Defense 0.03 -0.04 0.12 0.05 0.589 ArcA-regulated PROCESSES mechanisms AND SIGNALING EcolC_0204 b3513 mdtE anaerobic multidrug efflux transporter, CELLULAR Cell -0.02 0.20 0.50 0.72 0.394 ArcA-regulated PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0205 b3512 gadE DNA-binding transcriptional activator - - -0.33 -0.24 0.62 0.71 0.795 EcolC_0206 b3511 hdeD acid-resistance membrane protein POORLY Function -2.02 -2.29 0.76 0.49 0.060 CHARACTERIZ unknown ED EcolC_0207 b3510 hdeA stress response protein acid-resistance - - -3.62 -3.38 0.60 0.85 0.147 protein EcolC_0208 b3509 hdeB acid-resistance protein - - -2.78 -2.95 0.54 0.37 0.388 EcolC_0209 b3508 yhiD predicted Mg(2+) transport ATPase, inner POORLY Function -0.06 -0.07 0.31 0.31 0.911 membrane protein CHARACTERIZ unknown ED EcolC_0210 b3507 dctR predicted DNA-binding transcriptional CELLULAR Signal 0.08 -0.21 0.32 0.03 0.258 regulator PROCESSES transduction AND mechanisms SIGNALING EcolC_0211 b3506 slp outer membrane lipoprotein CELLULAR Cell 0.06 -0.14 0.64 0.45 0.138 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0212 b3504 yhiS - - - -0.14 -0.11 -0.04 -0.01 0.781 EcolC_0213 b3503 arsC arsenate reductase METABOLISM Inorganic ion 0.07 0.02 0.18 0.13 0.985 transport and metabolism EcolC_0214 b3502 arsB arsenite/antimonite transporter METABOLISM Inorganic ion 0.04 0.07 0.26 0.30 0.562 transport and metabolism EcolC_0215 b3501 arsR DNA-binding transcriptional repressor INFORMATION Transcription -0.17 -0.11 -0.10 -0.03 0.663 STORAGE AND PROCESSING EcolC_0216 b3500 gor glutathione METABOLISM Energy 0.26 0.51 -0.07 0.19 0.123 production and conversion EcolC_0217 b3499 rlmJ 23S rRNA m(6)A2030 methyltransferase, POORLY General 0.67 1.05 0.17 0.55 0.616 SAM-dependent CHARACTERIZ function ED prediction EcolC_0218 b3498 prlC oligopeptidase A METABOLISM Aminol acid -0.73 -0.47 -0.15 0.11 0.177 transport and metabolism EcolC_0219 b3497 rsmJ 16S rRNA m(2)G1516 methyltransferase, - - 0.54 0.84 0.44 0.74 0.340 SAM-dependent EcolC_0220 b3496 dtpB dipeptide and tripeptide permease B METABOLISM Amino acid 0.03 -0.36 0.10 -0.29 0.031 transport and metabolism EcolC_0221 b3495 uspA universal stress global response regulator CELLULAR Signal -2.44 -2.00 0.07 0.51 0.143 PROCESSES transduction AND mechanisms SIGNALING EcolC_0222 b3494 uspB universal stress (ethanol tolerance) protein - - -0.30 -0.49 0.47 0.28 0.526 B EcolC_0223 b3493 pitA phosphate transporter, low-affinity; METABOLISM Inorganic ion 0.06 -0.09 0.23 0.08 0.382 tellurite importer transport and metabolism EcolC_0224 b3492 yhiN predicted oxidoreductase with POORLY General 0.14 0.12 0.29 0.27 0.721 FAD/NAD(P)-binding domain CHARACTERIZ function ED prediction EcolC_0225 b3491 yhiM acid resistance protein, inner membrane - -l -0.01 0.01 0.30 0.32 0.599 EcolC_0226 b4660 yhiL - - - -0.34 -0.23 -0.33 -0.22 0.646 EcolC_0227 b3488 yhiJ predicted protein - - -0.03 -0.11 -0.19 -0.27 0.666 EcolC_0229 b3486 rbbA fused ribosome-associated ATPase: ATP- CELLULAR Defense 0.18 -0.44 0.07 -0.55 0.027 binding protein/ATP-binding PROCESSES mechanisms protein/predicted membrane protein AND SIGNALING EcolC_0230 b3485 yhhJ predicted permease subunit, ABC CELLULAR Defense 0.12 -0.04 0.26 0.11 0.972 transporter superfamily, inner membrane PROCESSES mechanisms protein AND SIGNALING EcolC_0233 b3483 yhhH predicted protein - - 0.32 0.02 0.14 -0.16 0.112 EcolC_0234 b3482 rhsB rhsB element core protein RshB; putative CELLULAR Cell 0.00 0.09 0.04 0.13 0.479 neighboring cell growth inhibitor PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0235 b3481 nikR DNA-binding transcriptional repressor, Ni- INFORMATION Transcription 0.23 0.25 0.28 0.29 0.559 binding STORAGE AND PROCESSING EcolC_0236 b3480 nikE nickel transporter subunit METABOLISM Amino acid -0.09 0.08 0.10 0.27 0.245 transport and metabolism EcolC_0238 b3478 nikC nickel transporter subunit METABOLISM Amino acid -0.35 -0.25 -0.18 -0.08 0.504 transport and metabolism EcolC_0239 b3477 nikB nickel transporter subunit METABOLISM Amino acid 0.01 0.03 0.03 0.05 0.999 transport and metabolism EcolC_0240 b3476 nikA nickel-binding, heme-binding periplasmic METABOLISM Amino acid -0.04 -0.10 0.08 0.02 0.797 protein transport and metabolism EcolC_0242 b3474 yhhT inner membrane protein, predicted POORLY General -0.05 0.06 0.48 0.59 0.751 membrane permease, UPF0118 family CHARACTERIZ function ED prediction l EcolC_0243 b3473 yhhS putative arabinose efflux transporter METABOLISM Carbohydrate 0.20 0.05 0.03 -0.12 0.246 transport and metabolism EcolC_0244 b3472 dcrB periplasmic protein, predicted lipoprotein - - 0.75 0.85 -0.06 0.04 0.927 EcolC_0245 b3471 yhhQ DUF165 family inner membrane protein POORLY Function -0.15 -0.12 0.13 0.15 0.982 CHARACTERIZ unknown ED EcolC_0246 - sirA sulfur transfer protein SirA CELLULAR Posttranslatio 0.25 1.24 0.02 1.01 0.019 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0246 b3470 tusA sulfurtransferase required 2-thiolation step CELLULAR Posttranslatio 0.12 -0.03 0.04 -0.11 0.887 of mnm(5)-s(2)U34-tRNA synthesis PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0247 b3469 zntA zinc, cobalt and lead efflux system METABOLISM Inorganic ion 0.61 0.86 -0.01 0.24 0.336 transport and metabolism EcolC_0248 b3468 yhhN predicted inner membrane protein, POORLY Function -0.41 -0.25 0.08 0.23 0.476 TMEM86 family CHARACTERIZ unknown ED EcolC_0249 b3467 yhhM conserved protein, DUF2500 family - - -0.70 -0.48 -0.68 -0.47 0.231 EcolC_0250 b3466 yhhL conserved protein, DUF1145 family POORLY Function 0.36 0.45 0.43 0.52 0.992 CHARACTERIZ unknown ED EcolC_0251 b3465 rsmD 16S rRNA m(2)G966 methyltransferase, INFORMATION Replication, 0.28 0.58 0.16 0.46 0.062 SAM-dependent STORAGE AND recombination PROCESSING and repair EcolC_0252 b3464 ftsY Signal Recognition Particle (SRP) receptor CELLULAR Intracellular 0.27 0.22 0.03 -0.02 0.734 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0253 b3463 ftsE predicted transporter subunit: ATP-binding CELLULAR Cell cycle 0.54 0.51 0.27 0.24 0.940 component of ABC superfamily PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_0254 b3462 ftsX predicted transporter subunit: membrane CELLULAR Cell cycle 0.32 0.24 0.25 0.17 0.209 component of ABC superfamily PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_0255 b3461 rpoH RNA polymerase, sigma 32 (sigma H) INFORMATION Transcription -0.43 -0.08 0.17 0.52 0.037 factor STORAGE AND PROCESSING EcolC_0256 b3460 livJ leucine/isoleucine/valine transporter METABOLISM Amino acid 0.85 0.59 0.44 0.18 0.380 subunit transport and metabolism EcolC_0257 b3459 panM PanD autocleavage accelerator, - - 0.04 0.25 0.25 0.46 0.127 panothenate synthesis EcolC_0258 b3458 livK leucine transporter subunit METABOLISM Amino acid 0.22 0.14 0.38 0.31 0.511 transport and metabolism EcolC_0260 b3456 livM leucine/isoleucine/valine transporter METABOLISM Amino acid 0.00 -0.03 0.14 0.11 0.584 subunit transport and metabolism EcolC_0261 b3455 livG leucine/isoleucine/valine transporter METABOLISM Amino acid -0.02 0.05 0.13 0.20 0.816 subunit transport and metabolism EcolC_0262 b3454 livF leucine/isoleucine/valine transporter METABOLISM Amino acid 0.07 -0.01 0.15 0.07 0.177 subunit transport and metabolism EcolC_0263 b3453 ugpB glycerol-3-phosphate transporter subunit METABOLISM Carbohydrate 0.61 -0.08 0.54 -0.15 0.118 transport and metabolism EcolC_0264 b3452 ugpA glycerol-3-phosphate transporter subunit METABOLISM Carbohydrate -0.08 -0.24 -0.10 -0.26 0.297 transport and metabolism EcolC_0265 b3451 ugpE glycerol-3-phosphate transporter subunit METABOLISM Carbohydrate -0.45 -1.00 -0.49 -1.05 0.026 transport and metabolism EcolC_0266 b3450 ugpC glycerol-3-phosphate transporter subunit METABOLISM Carbohydrate 0.24 -0.07 -0.47 -0.77 0.358 transport and metabolism EcolC_0267 b3449 ugpQ glycerophosphodiester phosphodiesterase, METABOLISM Energy 0.31 -0.11 0.11 -0.30 0.544 cytosolic production and conversion EcolC_0268 b3448 yhhA conserved protein, DUF2756 family - - 0.06 -0.40 0.61 0.15 0.014 EcolC_0269 b3447 ggt gamma-glutamyltranspeptidase METABOLISM Amino acid -0.05 -0.11 0.26 0.19 0.573 transport and metabolism EcolC_0272 b3441 yhhY predicted acetyltransferase INFORMATION Translation, 0.31 0.14 0.41 0.23 0.398 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0273 b3440 yhhX predicted oxidoreductase with NAD(P)- POORLY General -0.49 -0.20 0.24 0.53 0.268 binding Rossmann-fold domain CHARACTERIZ function ED prediction l EcolC_0274 b3439 yhhW quercetinase activity in vitro POORLY General 0.03 -0.04 0.49 0.43 0.732 CHARACTERIZ function ED prediction EcolC_0275 b3438 gntR DNA-binding transcriptional repressor INFORMATION Transcriptionl 0.37 0.61 0.32 0.56 0.109 STORAGE AND PROCESSING EcolC_0277 b4476 gntU gluconate transporter, low affinity GNT 1 METABOLISM Carbohydrate 0.01 0.16 0.03 0.18 0.246 system transport and metabolism EcolC_0278 b3434 yhgN predicted antibiotic transporter CELLULAR Intracellular 0.36 0.29 0.40 0.33 0.818 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0279 b3433 asd aspartate-semialdehyde dehydrogenase, METABOLISM Amino acid -1.49 -0.05 0.05 1.49 0.018 NAD(P)-binding transport and metabolism EcolC_0280 b3432 glgB 1,4-alpha-glucan branching METABOLISM Carbohydrate -1.34 -1.15 0.01 0.20 0.099 transport and metabolism EcolC_0281 b3431 glgX glycogen debranching enzyme METABOLISM Carbohydrate -0.69 -0.51 0.07 0.25 0.478 transport and metabolism EcolC_0282 b3430 glgC glucose-1-phosphate adenylyltransferase METABOLISM Carbohydrate -0.85 -1.19 -0.03 -0.37 0.265 transport and metabolism EcolC_0283 b3429 glgA glycogen synthase METABOLISM Carbohydrate -1.54 -1.02 0.11 0.62 0.102 transport and metabolism EcolC_0284 b3428 glgP glycogen phosphorylase METABOLISM Carbohydrate -1.18 -0.82 0.09 0.45 0.338 transport and metabolism EcolC_0285 b3427 yzgL - - - 0.00 -0.15 -0.08 -0.24 0.561 EcolC_0286 - - hypothetical protein METABOLISM Inorganic ion -0.07 -0.09 -0.21 -0.23 0.915 transport and metabolism EcolC_0288 b3426 glpD sn-glycerol-3-phosphate dehydrogenase, METABOLISM Energy 2.35 1.38 0.43 -0.54 0.027 aerobic, FAD/NAD(P)-binding production and conversion EcolC_0289 b3425 glpE thiosulfate:cyanide sulfurtransferase METABOLISM Inorganic ion 0.47 0.30 0.25 0.07 0.240 (rhodanese) transport and metabolism EcolC_0290 b3424 glpG rhomboid intramembrane serine protease POORLY General -0.28 -0.25 -0.10 -0.06 0.770 CHARACTERIZ function ED prediction EcolC_0291 b3423 glpR - - -l 0.12 0.24 0.44 0.55 0.536 EcolC_0292 b3422 rtcR sigma 54-dependent transcriptional INFORMATION Transcription 0.17 0.18 0.20 0.21 0.570 regulator of rtcBA expression STORAGE AND PROCESSING EcolC_0293 b3421 rtcB conserved protein POORLY Function 0.05 0.15 0.17 0.27 0.931 CHARACTERIZ unknown ED EcolC_0294 b4475 rtcA RNA 3'-terminal phosphate cyclase INFORMATION RNA 0.16 0.20 0.45 0.49 0.603 STORAGE AND processing PROCESSING and modification EcolC_0295 b3418 malT DNA-binding transcriptional activator for INFORMATION Transcription 0.04 -0.05 0.42 0.33 0.233 the mal regulon and maltotriose-ATP- STORAGE AND binding protein PROCESSING EcolC_0296 b3417 malP maltodextrin phosphorylase METABOLISM Carbohydrate -2.07 0.03 -0.20 1.90 0.001 transport and metabolism EcolC_0297 b3416 malQ 4-alpha-glucanotransferase (amylomaltase) METABOLISM Carbohydrate -2.18 -0.51 -0.37 1.30 0.001 transport and metabolism EcolC_0298 b3415 gntT gluconate transporter, high-affinity GNT I METABOLISM Carbohydrate -1.64 -0.29 -0.02 1.33 0.013 system transport and metabolism EcolC_0299 b3414 nfuA Fe/S biogenesis protein; possible CELLULAR Posttranslatio 0.73 0.91 -0.02 0.17 0.336 scaffold/chaperone for damaged Fe/S PROCESSES nal proteins AND modification, SIGNALING protein turnover, chaperones EcolC_0300 b3413 gntX protein required for the utilization of DNA POORLY General 0.24 0.55 -0.18 0.13 0.011 as a carbon source CHARACTERIZ function ED prediction EcolC_0301 b3412 bioH pimeloyl-ACP methyl ester POORLY Generall 0.11 0.69 0.14 0.72 0.100 CHARACTERIZ function ED prediction EcolC_0302 b3411 yhgA predicted POORLY Functionl 0.06 0.10 0.09 0.13 0.963 CHARACTERIZ unknown ED EcolC_0305 b3408 feoA ferrous iron transporter, protein A METABOLISM Inorganic ion 0.09 0.30 0.11 0.32 0.099 transport and metabolism EcolC_0306 b3407 yhgF predicted transcriptional accessory protein INFORMATION Transcription 0.22 -0.04 -0.18 -0.44 0.577 STORAGE AND PROCESSING EcolC_0307 b3406 greB transcript cleavage factor INFORMATION Transcription 0.32 -0.42 0.25 -0.48 0.187 STORAGE AND PROCESSING EcolC_0308 b3405 ompR DNA-binding response regulator in two- CELLULAR Signal 0.26 -0.22 -0.01 -0.48 0.008 component regulatory system with EnvZ PROCESSES transduction AND mechanisms SIGNALING EcolC_0309 b3404 envZ sensory histidine kinase in two-component CELLULAR Signal 0.39 0.49 0.45 0.55 0.990 regulatory system with OmpR PROCESSES transduction AND mechanisms SIGNALING EcolC_0310 b3403 pck phosphoenolpyruvate carboxykinase METABOLISM Energy -0.60 0.04 0.00 0.64 0.043 production and conversion EcolC_0311 b3402 yhgE predicted inner membrane protein - - 0.01 -0.09 0.10 0.00 0.629 EcolC_0312 b3401 hslO heat shock protein Hsp33 CELLULAR Posttranslatio 0.30 0.43 0.50 0.64 0.680 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0313 b3400 hslR ribosome-associated heat shock protein INFORMATION Translation, 0.35 0.56 0.26 0.47 0.106 Hsp15 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0314 b3399 yrfG GMP/IMP POORLY General 0.14 0.22 0.13 0.21 0.968 CHARACTERIZ function ED prediction EcolC_0315 b3398 yrfF inner membrane protein - -l 0.49 0.39 0.42 0.32 0.982 EcolC_0316 b3397 nudE adenosine nucleotide ; substrates INFORMATION Replication, 0.18 0.14 0.12 0.08 0.965 include Ap3A, Ap2A, ADP-ribose, NADH STORAGE AND recombination PROCESSING and repair EcolC_0317 b3396 mrcA fused penicillin-binding protein 1a: murein CELLULAR Cell 0.42 0.28 0.34 0.20 0.953 transglycosylase/murein transpeptidase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0320 b3393 hofO protein required for the utilization of DNA - - 0.10 0.04 0.09 0.03 0.768 as a carbon source EcolC_0322 b3391 hofQ protein required for the utilization of DNA CELLULAR Intracellular 0.01 -0.01 0.16 0.14 0.836 as a carbon source; fimbrial transporter PROCESSES trafficking, homolog AND secretion, and SIGNALING vesicular transport EcolC_0323 b3390 aroK I METABOLISM Amino acid -0.13 -0.11 -0.08 -0.06 0.899 transport and metabolism EcolC_0324 b3389 aroB 3-dehydroquinate synthase METABOLISM Amino acid 0.27 0.24 0.16 0.13 0.344 transport and metabolism EcolC_0325 b3388 damX cell division protein that binds to the septal POORLY Function 0.35 0.41 0.06 0.13 0.455 ring CHARACTERIZ unknown ED EcolC_0326 b3387 dam DNA adenine methyltransferase INFORMATION Replication, -0.17 -0.11 0.03 0.09 0.923 STORAGE AND recombination PROCESSING and repair EcolC_0327 b3386 rpe D-ribulose-5-phosphate 3-epimerase METABOLISM Carbohydrate -0.77 -0.31 -0.22 0.24 0.029 transport and metabolism EcolC_0328 b3385 gph phosphoglycolate phosphatase POORLY General -0.33 -0.14 -0.13 0.07 0.146 CHARACTERIZ function ED prediction l EcolC_0329 b3384 trpS tryptophanyl-tRNA synthetase INFORMATION Translation, 0.20 0.11 0.22 0.12 0.219 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0330 b3383 yhfZ conserved protein - - 0.33 0.21 0.48 0.36 0.639 EcolC_0331 b3382 yhfY conserved protein - - -0.01 -0.02 0.15 0.14 0.715 EcolC_0332 b3381 yhfX predicted amino acid racemase METABOLISM Amino acid 0.10 -0.09 -0.08 -0.27 0.412 transport and metabolism EcolC_0333 b3380 yhfW predicted mutase METABOLISM Carbohydrate -0.10 -0.03 0.08 0.15 0.540 transport and metabolism EcolC_0334 b3379 php predicted hydrolase POORLY General -0.08 0.02 0.20 0.30 0.093 CHARACTERIZ function ED prediction EcolC_0335 b3378 yhfU predicted protein - -l 0.03 -0.09 0.18 0.06 0.629 EcolC_0337 b3376 yhfS conserved protein INFORMATION Transcription 0.35 0.49 0.55 0.68 0.306 STORAGE AND PROCESSING EcolC_0338 b3375 frlR predicted DNA-binding transcriptional INFORMATION Transcription -0.22 -0.15 0.20 0.27 0.552 regulator STORAGE AND PROCESSING EcolC_0339 b3374 frlD fructoselysine 6-kinase METABOLISM Carbohydrate 0.16 0.06 0.26 0.17 0.414 transport and metabolism EcolC_0340 b4474 frlC fructoselysine 3-epimerase METABOLISM Carbohydrate 0.24 0.13 0.30 0.19 0.517 transport and metabolism EcolC_0341 b3371 frlB fructoselysine-6-P-deglycase CELLULAR Cell 0.36 0.47 0.29 0.40 0.743 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0342 b3370 frlA predicted fructoselysine transporter METABOLISM Amino acid -0.05 -0.11 -0.16 -0.21 0.631 transport and metabolism EcolC_0343 b3369 yhfL small lipoprotein - - -0.10 -0.32 -0.13 -0.34 0.445 EcolC_0344 b3368 cysG fused siroheme synthase 1,3- METABOLISM Coenzyme 0.00 0.06 0.18 0.24 0.395 dimethyluroporphyriongen III transport and dehydrogenase and siroheme metabolism ferrochelatase/uroporphyrinogen methyltransferase EcolC_0345 b3367 nirC nitrite transporter METABOLISM Inorganic ion -0.06 0.00 0.02 0.08 0.594 transport and metabolism EcolC_0346 b3366 nirD nitrite reductase, NAD(P)H-binding, small METABOLISM Inorganic ion 0.39 0.56 0.49 0.66 0.902 subunit transport and metabolism EcolC_0347 b3365 nirB nitrite reductase, large subunit, NAD(P)H- METABOLISM Energy -0.19 0.47 0.04 0.70 0.184 binding production and conversion EcolC_0348 b3364 tsgA predicted transporter METABOLISM Carbohydrate 0.14 0.25 0.44 0.55 0.909 transport and metabolism EcolC_0349 b3363 ppiA peptidyl-prolyl cis-trans isomerase A CELLULAR Posttranslatio 0.55 0.71 0.35 0.52 0.526 (rotamase A) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0350 b3362 yhfG predicted Fic-binding protein - - -1.35 -2.11 0.72 -0.04 0.004 EcolC_0351 b3361 fic stationary-phase adenosine CELLULAR Cell cycle -1.69 -2.43 0.71 -0.03 0.011 monophosphate-protein transferase domain PROCESSES control, cell protein AND division, SIGNALING chromosome partitioning EcolC_0352 b3360 pabA aminodeoxychorismate synthase, subunit II METABOLISM Amino acid -0.07 -0.59 0.47 -0.05 0.221 transport and metabolism EcolC_0353 b3359 argD bifunctional acetylornithine METABOLISM Amino acid -0.23 -0.08 0.02 0.17 0.641 aminotransferase/ succinyldiaminopimelate transport and aminotransferase metabolism EcolC_0354 b3358 yhfK conserved inner membrane protein POORLY Function 0.84 0.63 0.42 0.21 0.547 CHARACTERIZ unknown ED EcolC_0355 b3357 crp cAMP-activated global transcription factor, CELLULAR Signal -0.27 -0.65 0.08 -0.29 0.011 mediator of catabolite repression PROCESSES transduction AND mechanisms SIGNALING EcolC_0356 b3356 yhfA conserved protein, OsmC family CELLULAR Posttranslatio 0.20 0.71 0.41 0.92 0.016 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0357 b3355 prkB predicted phosphoribulokinase METABOLISM Energy -0.49 -0.27 0.22 0.44 0.368 production and conversion EcolC_0358 b3354 yheU conserved protein POORLY Function 0.19 0.35 0.42 0.58 0.308 CHARACTERIZ unknown ED EcolC_0359 b3353 yheT predicted hydrolase POORLY General 0.23 0.45 0.21 0.43 0.361 CHARACTERIZ function ED prediction EcolC_0360 b3352 yheS fused predicted transporter subunits of POORLY Generall 0.21 0.48 0.31 0.58 0.291 ABC superfamily: ATP-binding CHARACTERIZ function components ED prediction EcolC_0361 b3351 kefG potassium-efflux system ancillary protein POORLY Generall 0.54 0.11 0.13 -0.29 0.095 for KefB, glutathione-regulated CHARACTERIZ function ED prediction EcolC_0362 b3350 kefB potassium:proton antiporter METABOLISM Inorganicl ion 0.47 -0.17 0.53 -0.11 0.015 transport and metabolism EcolC_0363 b4551 yheV predicted protein POORLY General 0.22 0.23 0.40 0.41 0.787 CHARACTERIZ function ED prediction EcolC_0364 b3349 slyD FKBP-type peptidyl prolyl cis-trans CELLULAR Posttranslatiol -0.25 -0.34 0.10 0.00 0.893 isomerase (rotamase) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0365 b3348 slyX protein required for phi X174 lysis POORLY Function 0.07 0.27 0.42 0.62 0.509 CHARACTERIZ unknown ED EcolC_0366 b3347 fkpA FKBP-type peptidyl-prolyl cis-trans CELLULAR Posttranslatio 0.50 0.22 0.38 0.11 0.716 isomerase (rotamase) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0367 b3346 yheO conserved protein POORLY Function -0.30 -0.22 0.01 0.10 0.995 CHARACTERIZ unknown ED EcolC_0368 b3345 tusD sulfurtransferase for 2-thiolation step of METABOLISM Inorganic ion 0.09 -0.12 0.14 -0.07 0.445 mnm(5)-s(2)U34-tRNA synthesis transport and metabolism EcolC_0369 b3344 tusC protein required for 2-thiolation step of METABOLISM Inorganic ion 0.11 0.40 0.33 0.62 0.067 mnm(5)-s(2)U34-tRNA synthesis transport and metabolism EcolC_0370 b3343 tusB protein required for 2-thiolation step of METABOLISM Inorganic ion 0.03 0.25 0.30 0.51 0.953 mnm(5)-s(2)U34-tRNA synthesis transport and metabolism EcolC_0371 b3342 rpsL 30S ribosomal subunit protein S12 INFORMATION Translation, -1.95 -1.11 -0.09 0.74 0.046 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0372 b3341 rpsG 30S ribosomal subunit protein S7 INFORMATION Translation, -2.01 -1.13 -0.22 0.65 0.001 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0373 b3340 fusA protein chain elongation factor EF-G, GTP- INFORMATION Translation, -1.71 -0.48 -0.04 1.20 0.040 binding STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0375 b3338 chiA periplasmic endochitinase - - 0.19 -0.03 0.33 0.12 0.126 EcolC_0376 b3337 bfd bacterioferritin-associated ferredoxin METABOLISM Inorganic ion 0.21 0.31 0.34 0.44 0.919 transport and metabolism EcolC_0377 b3336 bfr bacterioferritin, iron storage and METABOLISM Inorganic ion -0.42 -1.24 0.34 -0.48 0.013 detoxification protein transport and metabolism EcolC_0378 b3335 gspO bifunctional prepilin leader peptidase/ CELLULAR Cell motility -0.16 -0.59 0.11 -0.31 0.504 methylase PROCESSES AND SIGNALING EcolC_0379 b3334 gspM general secretory pathway component, CELLULAR Intracellular 0.05 0.03 0.44 0.42 0.669 cryptic PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0380 b3333 gspL general secretory pathway component, CELLULAR Intracellular -0.01 0.28 0.37 0.66 0.006 cryptic PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0381 b3332 gspK general secretory pathway component, CELLULAR Intracellular 0.26 0.25 0.27 0.26 0.708 cryptic PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0382 b3331 gspJ predicted general secretory pathway CELLULAR Intracellular -0.02 -0.15 -0.04 -0.18 0.650 component, cryptic PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0383 b3330 gspI general secretory pathway component, CELLULAR Cell motility -0.03 -0.11 0.13 0.05 0.358 cryptic PROCESSES AND SIGNALING EcolC_0384 b3329 gspH predicted general secretory pathway - - 0.05 0.14 0.07 0.16 0.665 component, cryptic EcolC_0385 b3328 gspG pseudopilin, cryptic, general secretion CELLULAR Cell motility -0.08 -0.10 0.17 0.15 0.923 pathway PROCESSES AND SIGNALING EcolC_0386 b3327 gspF general secretory pathway component, CELLULAR Cell motility -0.10 -0.33 -0.04 -0.27 0.738 cryptic PROCESSES AND SIGNALING EcolC_0387 b3326 gspE general secretory pathway component, CELLULAR Cell motility 0.03 0.00 0.08 0.06 0.826 cryptic PROCESSES AND SIGNALING EcolC_0388 b3325 gspD general secretory pathway component, CELLULAR Cell motility 0.13 0.34 0.34 0.55 0.386 cryptic PROCESSES AND SIGNALING EcolC_0389 b3324 gspC general secretory pathway component, CELLULAR Intracellular -0.14 -0.02 0.09 0.21 0.363 cryptic PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0390 b3323 gspA general secretory pathway component, - - 0.15 0.18 0.17 0.21 0.976 cryptic EcolC_0391 b3322 gspB part of gsp divergon involved in type II - - 0.11 0.10 0.39 0.37 0.792 protein secretion EcolC_0392 b3321 rpsJ 30S ribosomal subunit protein S10 INFORMATION Translation, -2.72 -0.65 -0.05 2.02 0.005 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0393 b3320 rplC 50S ribosomal subunit protein L3 INFORMATION Translation, -3.11 -0.93 -0.13 2.05 0.003 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0394 b3319 rplD 50S ribosomal subunit protein L4 INFORMATION Translation, -3.14 -1.21 -0.18 1.75 0.002 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0395 b3318 rplW 50S ribosomal subunit protein L23 INFORMATION Translation, -3.19 -1.08 -0.11 1.99 0.003 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0396 b3317 rplB 50S ribosomal subunit protein L2 INFORMATION Translation, -2.72 -0.95 -0.06 1.71 0.003 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0397 b3316 rpsS 30S ribosomal subunit protein S19 INFORMATION Translation, -3.33 -0.99 -0.10 2.23 0.011 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0398 b3315 rplV 50S ribosomal subunit protein L22 INFORMATION Translation, -2.92 -1.26 -0.10 1.57 0.002 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0399 b3314 rpsC 30S ribosomal subunit protein S3 INFORMATION Translation, -2.84 -1.71 -0.01 1.12 0.033 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0400 b3313 rplP 50S ribosomal subunit protein L16 INFORMATION Translation, -2.46 -1.18 0.02 1.30 0.001 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0401 b3312 rpmC 50S ribosomal subunit protein L29 INFORMATION Translation, -2.94 -2.32 -0.02 0.59 0.059 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0402 b3311 rpsQ 30S ribosomal subunit protein S17 INFORMATION Translation, -2.23 -1.59 0.02 0.67 0.419 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0403 b3310 rplN 50S ribosomal subunit protein L14 INFORMATION Translation, -1.78 -2.04 -0.16 -0.42 0.125 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0404 b3309 rplX 50S ribosomal subunit protein L24 INFORMATION Translation, -1.50 -1.72 -0.14 -0.36 0.036 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0405 b3308 rplE 50S ribosomal subunit protein L5 INFORMATION Translation, -1.97 -2.12 -0.26 -0.41 0.462 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0406 b3307 rpsN 30S ribosomal subunit protein S14 INFORMATION Translation, -1.34 -1.77 -0.13 -0.56 0.101 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0407 b3306 rpsH 30S ribosomal subunit protein S8 INFORMATION Translation, -2.31 -2.24 -0.13 -0.06 0.825 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0408 b3305 rplF 50S ribosomal subunit protein L6 INFORMATION Translation, -1.67 -1.92 -0.05 -0.30 0.336 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0409 b3304 rplR 50S ribosomal subunit protein L18 INFORMATION Translation, -2.14 -2.34 0.04 -0.16 0.184 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0410 b3303 rpsE 30S ribosomal subunit protein S5 INFORMATION Translation, -1.71 -2.20 0.11 -0.38 0.123 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0411 b3302 rpmD 50S ribosomal subunit protein L30 INFORMATION Translation, -2.53 -2.61 0.03 -0.05 0.562 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0412 b3301 rplO 50S ribosomal subunit protein L15 INFORMATION Translation, -1.82 -2.08 0.14 -0.11 0.221 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0413 b3300 secY preprotein membrane subunit CELLULAR Intracellular -2.06 -0.98 0.09 1.17 0.139 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0414 b3299 rpmJ 50S ribosomal subunit protein L36 INFORMATION Translation, -0.43 0.06 0.15 0.64 0.005 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0415 b3298 rpsM 30S ribosomal subunit protein S13 INFORMATION Translation, -1.90 -0.52 0.02 1.40 0.043 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0416 b3297 rpsK 30S ribosomal subunit protein S11 INFORMATION Translation, -0.03 0.23 0.29 0.56 0.197 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0417 b3296 rpsD 30S ribosomal subunit protein S4 INFORMATION Translation, -2.40 -1.10 0.01 1.31 0.003 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0418 b3295 rpoA RNA polymerase, alpha subunit INFORMATION Transcription -1.57 -0.82 -0.08 0.67 0.060 STORAGE AND PROCESSING EcolC_0419 b3294 rplQ 50S ribosomal subunit protein L17 INFORMATION Translation, -1.34 -0.86 -0.04 0.44 0.284 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0420 b3293 yhdN conserved protein, DUF1992 family - - 0.18 0.29 -0.03 0.09 0.479 EcolC_0421 b3292 zntR DNA-binding transcriptional activator in INFORMATION Transcription 0.16 0.35 0.31 0.50 0.823 response to Zn(II) STORAGE AND PROCESSING EcolC_0422 b4550 arfA alternate ribosome-rescue factor A POORLY Function 0.34 0.71 0.36 0.73 0.354 CHARACTERIZ unknown ED EcolC_0423 b3291 mscL mechanosensitive channel protein, high CELLULAR Cell 0.22 0.28 0.34 0.41 0.742 conductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0424 b3290 trkA NAD-binding component of TrK potassium METABOLISM Inorganic ion 0.23 0.49 0.25 0.50 0.261 transporter transport and metabolism EcolC_0425 b3289 rsmB 16S rRNA m(5)C967 methyltransferase, INFORMATION Translation, -0.03 0.13 0.05 0.21 0.413 SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0426 b3288 fmt 10-formyltetrahydrofolate:L-methionyl- INFORMATION Translation, -0.14 -0.02 -0.01 0.11 0.836 tRNA(fMet) N-formyltransferase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0427 b3287 def peptide deformylase INFORMATION Translation, -0.13 -0.40 0.04 -0.24 0.469 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0428 b4473 smf conserved protein INFORMATION Replication, -0.03 -0.02 0.29 0.29 0.742 STORAGE AND recombination PROCESSING and repair EcolC_0429 b3284 smg conserved protein POORLY Function -0.54 -0.97 0.31 -0.12 0.072 CHARACTERIZ unknown ED EcolC_0430 b3283 yrdD predicted DNA topoisomerase INFORMATION Replication, 0.00 -0.08 0.18 0.10 0.561 STORAGE AND recombination PROCESSING and repair EcolC_0431 b3282 tsaC tRNA(ANN) t(6)A37 INFORMATION Translation, -0.03 0.12 0.12 0.26 0.072 threonylcarbamoyladenosine modification STORAGE AND ribosomal protein, threonine-dependent ADP-forming PROCESSING structure and ATPase biogenesis EcolC_0432 b3281 aroE dehydroshikimate reductase, NAD(P)- METABOLISM Amino acid 0.24 -0.08 0.26 -0.05 0.063 binding transport and metabolism EcolC_0433 b3280 yrdB conserved protein - - 0.29 0.37 0.62 0.70 0.808 EcolC_0434 b3279 yrdA conserved protein POORLY General -0.27 -0.13 0.09 0.23 0.233 CHARACTERIZ function ED prediction l EcolC_0435 b3271 yhdZ predicted amino-acid transporter subunit METABOLISM Amino acid 0.14 0.17 0.45 0.47 0.608 transport and metabolism EcolC_0436 b3270 yhdY predicted amino-acid transporter subunit METABOLISM Amino acid -0.02 -0.02 0.13 0.13 0.727 transport and metabolism EcolC_0437 b3269 yhdX predicted amino-acid transporter subunit METABOLISM Amino acid -0.28 -0.22 -0.23 -0.18 0.902 transport and metabolism EcolC_0438 b3268 yhdW - - - -0.07 -0.04 0.31 0.34 0.947 EcolC_0439 b3267 yhdV predicted outer membrane protein - - 0.60 0.58 0.15 0.13 0.713 EcolC_0440 b3266 acrF multidrug efflux system protein CELLULAR Defense 0.04 -0.18 -0.08 -0.30 0.354 PROCESSES mechanisms AND SIGNALING EcolC_0441 b3265 acrE cytoplasmic membrane lipoprotein CELLULAR Cell -0.02 -0.02 -0.07 -0.07 0.995 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0442 b3264 envR DNA-binding transcriptional regulator INFORMATION Transcription -0.13 -0.15 -0.03 -0.05 0.822 STORAGE AND PROCESSING EcolC_0443 b3263 yhdU predicted membrane protein - - -0.36 -0.18 -0.17 0.00 0.357 EcolC_0444 b3262 yhdJ DNA adenine methyltransferase, SAM- INFORMATION Replication, -0.07 -0.10 0.16 0.13 0.715 dependent STORAGE AND recombination PROCESSING and repair EcolC_0445 b3261 global DNA-binding transcriptional dual INFORMATION Transcription -0.19 0.06 0.28 0.53 0.358 regulator STORAGE AND PROCESSING EcolC_0446 b3260 dusB tRNA-dihydrouridine synthase B INFORMATION Translation, -0.41 -0.08 0.32 0.65 0.074 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0447 b3259 prmA methyltransferase for 50S ribosomal INFORMATION Translation, 0.34 0.31 0.51 0.48 0.801 subunit protein L11 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0448 b3258 panF pantothenate:sodium symporter METABOLISM Coenzyme 0.17 0.26 0.24 0.34 0.591 transport and metabolism EcolC_0449 b3257 yhdT conserved inner membrane protein POORLY Function 0.04 0.28 0.31 0.55 0.027 CHARACTERIZ unknown ED EcolC_0450 b3256 accC acetyl-CoA carboxylase, biotin carboxylase METABOLISM Lipid 0.20 0.05 0.37 0.22 0.787 subunit transport and metabolism EcolC_0451 b3255 accB acetyl CoA carboxylase, BCCP subunit METABOLISM Lipid -0.33 -0.68 0.23 -0.12 0.084 transport and metabolism EcolC_0454 b3253 acuI predicted acryloyl-CoA reductase METABOLISM Energy -1.16 -0.63 -0.18 0.35 0.020 production and conversion EcolC_0455 b3252 csrD targeting factor for csrBC sRNA CELLULAR Signal 0.17 0.15 0.38 0.37 0.709 degradation PROCESSES transduction AND mechanisms SIGNALING EcolC_0456 b3251 mreB cell wall structural complex MreBCD, CELLULAR Cell cycle -0.16 -0.24 -0.14 -0.22 0.986 actin-like component MreB PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_0457 b3250 mreC cell wall structural complex MreBCD CELLULAR Cell -0.30 -0.28 -0.17 -0.14 0.921 transmembrane component MreC PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0458 b3249 mreD cell wall structural complex MreBCD CELLULAR Cell -0.37 -0.36 0.16 0.17 0.546 transmembrane component MreD PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0459 b3248 yhdE Maf-like protein CELLULAR Cell cycle -0.20 -0.41 0.41 0.20 0.002 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_0460 b3247 rng G INFORMATION Translation, 0.14 0.13 0.41 0.41 0.893 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0461 b4472 yhdP conserved membrane protein, predicted POORLY Function -0.07 -0.10 0.09 0.06 0.981 transporter CHARACTERIZ unknown ED EcolC_0462 b3244 tldD predicted peptidase POORLY General -0.17 0.11 0.35 0.63 0.404 CHARACTERIZ function ED prediction EcolC_0464 b3242 aaeX membrane protein of efflux system - -l -0.41 -0.26 0.07 0.22 0.099 EcolC_0465 b3241 aaeA p-hydroxybenzoic acid efflux system CELLULAR Defense -0.36 -0.08 0.02 0.30 0.030 component PROCESSES mechanisms AND SIGNALING EcolC_0466 b3240 aaeB p-hydroxybenzoic acid efflux system POORLY Function 0.24 0.23 0.53 0.52 0.795 component CHARACTERIZ unknown ED EcolC_0467 b3239 yhcO predicted barnase inhibitor INFORMATION Transcription 0.03 0.09 0.45 0.51 0.657 STORAGE AND PROCESSING EcolC_0468 b3238 yhcN conserved protein - - 0.74 -0.46 0.33 -0.86 0.002 EcolC_0469 b3237 argR DNA-binding transcriptional dual INFORMATION Transcription 0.19 0.09 0.52 0.43 0.415 regulator, L-arginine-binding STORAGE AND PROCESSING EcolC_0470 b3236 mdh malate dehydrogenase, NAD(P)-binding METABOLISM Energy -0.42 -0.91 -0.27 -0.76 0.171 production and conversion EcolC_0471 b3235 degS serine endoprotease, periplasmic CELLULAR Posttranslatio 0.04 0.05 0.25 0.26 0.730 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0472 b3234 degQ serine endoprotease, periplasmic CELLULAR Posttranslatio 0.30 0.13 0.40 0.23 0.012 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0473 b3233 yhcB conserved protein POORLY Function -0.75 -0.70 0.02 0.06 0.541 CHARACTERIZ unknown ED EcolC_0474 b3232 yhcM conserved protein with nucleoside POORLY General 0.01 0.18 0.23 0.40 0.256 triphosphate hydrolase domain CHARACTERIZ function ED prediction EcolC_0475 b3231 rplM 50S ribosomal subunit protein L13 INFORMATION Translation,l -2.41 -1.63 -0.09 0.69 0.019 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0476 b3230 rpsI 30S ribosomal subunit protein S9 INFORMATION Translation, -1.17 -0.76 -0.01 0.40 0.251 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0477 b3229 sspA stringent starvation protein A, phage P1 CELLULAR Posttranslatio 0.27 0.67 0.04 0.45 0.017 late gene activator, RNAP-associated acid- PROCESSES nal resistance protein, inactive glutathione S- AND modification, transferase homolog SIGNALING protein turnover, chaperones EcolC_0478 b3228 sspB ClpXP protease specificity enhancing POORLY General 0.57 0.69 0.46 0.59 0.946 factor CHARACTERIZ function ED prediction EcolC_0479 b3227 dcuD predicted transporter METABOLISM Energyl 0.37 0.29 0.12 0.03 0.834 production and conversion EcolC_0480 b3226 nanR DNA-binding transcriptional repressor of INFORMATION Transcription -0.60 -0.44 0.05 0.21 0.283 the nan operon, induced by sialic acid STORAGE AND PROCESSING EcolC_0481 b3225 nanA N-acetylneuraminate lyase METABOLISM Amino acid -3.04 -3.19 -0.31 -0.47 0.850 transport and metabolism EcolC_0482 b3224 nanT sialic acid transporter METABOLISM Carbohydrate -1.47 -1.45 -0.03 0.00 0.737 transport and metabolism EcolC_0483 b3223 nanE predicted N-acetylmannosamine-6-P METABOLISM Carbohydrate -0.59 -0.67 0.07 -0.01 0.476 epimerase transport and metabolism EcolC_0484 b3222 nanK N-acetylmannosamine kinase INFORMATION Transcription -1.04 -1.10 -0.01 -0.08 0.676 STORAGE AND PROCESSING EcolC_0485 b3221 yhcH conserved protein METABOLISM Carbohydrate -0.55 -0.61 0.24 0.18 0.389 transport and metabolism EcolC_0487 b3213 gltD glutamate synthase, 4Fe-4S protein, small METABOLISM Amino acid -0.13 0.09 0.22 0.44 0.552 subunit transport and metabolism EcolC_0488 b3212 gltB glutamate synthase, large subunit METABOLISM Amino acid -0.28 -0.05 0.24 0.47 0.139 transport and metabolism EcolC_0489 b3211 yhcC predicted Fe-S oxidoreductase POORLY General -0.02 0.20 0.47 0.68 0.264 CHARACTERIZ function ED prediction EcolC_0490 b3210 arcB aerobic respiration control sensor histidine CELLULAR Signall -0.13 -0.37 -0.02 -0.26 0.153 , cognate to two-component PROCESSES transduction response regulators ArcA and RssB AND mechanisms SIGNALING EcolC_0491 b3209 elbB isoprenoid biosynthesis protein with METABOLISM Secondary -0.66 -0.41 0.13 0.37 0.074 amidotransferase-like domain metabolites biosynthesis, transport and catabolism EcolC_0492 b3208 mtgA biosynthetic peptidoglycan CELLULAR Cell 0.28 0.00 0.36 0.07 0.011 transglycosylase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0494 b3206 npr phosphohistidinoprotein-hexose METABOLISM Carbohydrate 0.15 0.23 0.24 0.33 0.494 component of N- transport and regulated PTS system (Npr) metabolism EcolC_0495 b3205 yhbJ adaptor protein RapZ for GlmZ/GlmY POORLY General -0.19 -0.22 0.04 0.01 0.995 sRNA decay; glucosamine-6-phosphate CHARACTERIZ function regulated; NTPase ED prediction EcolC_0496 b3204 ptsN sugar-specific enzyme IIA component of METABOLISM Carbohydratel -0.84 -0.27 -0.09 0.48 0.002 PTS transport and metabolism EcolC_0497 b3203 hpf ribosome hibernation promoting factor INFORMATION Translation, -1.06 -0.93 0.07 0.21 0.357 HPF; stabilizes 70S dimers (100S) STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0498 b3202 rpoN RNA polymerase, sigma 54 (sigma N) INFORMATION Transcription -1.12 -0.84 0.03 0.31 0.224 factor STORAGE AND PROCESSING EcolC_0499 b3201 lptB lipopolysaccharide export ABC transporter POORLY General -0.06 -0.19 -0.02 -0.15 0.851 ATP-binding protein of the LptBFGC CHARACTERIZ function export complex ED prediction EcolC_0500 b3200 lptA periplasmic LPS-binding protein POORLY Functionl -0.16 -0.20 -0.16 -0.21 0.744 CHARACTERIZ unknown ED EcolC_0501 b3199 lptC lipopolysaccharide export, IM-tethered POORLY Function 0.22 0.05 0.09 -0.07 0.480 periplasmic protein of the LptBFGC export CHARACTERIZ unknown complex ED EcolC_0502 b3198 kdsC 3-deoxy-D-manno-octulosonate 8- POORLY General -0.02 -0.12 -0.11 -0.21 0.606 phosphate phosphatase CHARACTERIZ function ED prediction EcolC_0503 b3197 kdsD D-arabinose 5-phosphate isomerase CELLULAR Celll 0.20 0.12 0.15 0.07 0.862 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0504 b3196 yrbG predicted calcium/sodium:proton antiporter METABOLISM Inorganic ion 0.17 0.09 0.12 0.04 0.742 transport and metabolism EcolC_0505 b3195 mlaF ABC transporter maintaining OM lipid METABOLISM Secondary 1.07 -0.18 0.08 -1.17 0.001 asymmetry, ATP-binding protein metabolites biosynthesis, transport and catabolism EcolC_0506 b3194 mlaE ABC transporter maintaining OM lipid METABOLISM Secondary 0.92 -0.42 -0.02 -1.36 0.006 asymmetry, inner membrane permease metabolites protein biosynthesis, transport and catabolism EcolC_0507 b3193 mlaD ABC transporter maintaining OM lipid METABOLISM Secondary 0.78 -0.72 -0.18 -1.68 0.003 asymmetry, anchored periplasmic binding metabolites protein biosynthesis, transport and catabolism EcolC_0508 b3192 mlaC ABC transporter maintaining OM lipid METABOLISM Secondary 0.27 -0.40 -0.23 -0.90 0.057 asymmetry, periplasmic binding protein metabolites biosynthesis, transport and catabolism EcolC_0509 b3191 mlaB ABC transporter maintaining OM lipid POORLY General 0.61 0.63 0.23 0.26 0.729 asymmetry, cytoplasmic STAS component CHARACTERIZ function ED prediction EcolC_0510 b3190 ibaG acid stress protein; predicted INFORMATION Transcriptionl 0.20 -0.01 -0.08 -0.29 0.280 transcriptional regulator, BolA family STORAGE AND PROCESSING EcolC_0511 b3189 murA UDP-N-acetylglucosamine 1- CELLULAR Cell -0.02 0.24 0.01 0.27 0.843 carboxyvinyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0512 b3188 sfsB DNA-binding transcriptional activator of INFORMATION Transcription -0.04 -0.05 -0.02 -0.03 0.756 maltose metabolism STORAGE AND PROCESSING EcolC_0513 b3187 ispB octaprenyl diphosphate synthase METABOLISM Coenzyme -1.36 -1.26 0.08 0.18 0.598 transport and metabolism EcolC_0514 b3186 rplU 50S ribosomal subunit protein L21 INFORMATION Translation, -1.80 -1.04 -0.19 0.57 0.010 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0515 b3185 rpmA 50S ribosomal subunit protein L27 INFORMATION Translation, -0.45 -0.22 0.00 0.23 0.897 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0516 b3184 yhbE predicted inner membrane permease POORLY General -0.11 -0.11 0.28 0.28 0.715 CHARACTERIZ function ED prediction EcolC_0517 b3183 obgE GTPase involved in cell partioning and POORLY Generall 0.11 0.35 0.27 0.51 0.406 DNA repair CHARACTERIZ function ED prediction EcolC_0518 b3182 dacB D-alanyl-D-alanine carboxypeptidase CELLULAR Celll -3.24 0.28 -0.81 2.71 0.039 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0519 b3181 greA transcript cleavage factor INFORMATION Transcription -0.41 0.06 0.26 0.73 0.197 STORAGE AND PROCESSING EcolC_0520 b3180 yhbY RNA binding protein associated with pre- INFORMATION Translation, -0.94 -1.28 0.08 -0.26 0.354 50S ribosomal subunits STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0521 b3179 rlmE 23S rRNA U2552 2'-O-ribose INFORMATION Translation, 0.21 -0.50 0.10 -0.60 0.000 methyltransferase, SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0522 b3178 ftsH protease, ATP-dependent zinc-metallo CELLULAR Posttranslatio 0.09 -0.48 -0.12 -0.69 0.030 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0523 b3177 folP 7,8-dihydropteroate synthase METABOLISM Coenzyme 0.59 0.15 0.03 -0.40 0.507 transport and metabolism EcolC_0524 b3176 glmM phosphoglucosamine mutase METABOLISM Carbohydrate -0.28 -0.46 -0.25 -0.43 0.120 transport and metabolism EcolC_0525 b3175 secG preprotein translocase membrane subunit CELLULAR Intracellular -0.49 -0.20 0.05 0.34 0.365 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0526 b3173 yhbX predicted hydrolase, inner membrane POORLY General -0.15 -0.19 0.00 -0.04 0.838 CHARACTERIZ function ED prediction EcolC_0527 b3172 argG argininosuccinate synthetase METABOLISM Aminol acid 0.30 0.23 0.19 0.12 0.431 transport and metabolism EcolC_0528 b3170 rimP ribosome maturation factor for 30S POORLY Function -0.71 -0.53 -0.06 0.12 0.382 subunits CHARACTERIZ unknown ED EcolC_0529 b3169 nusA transcription termination/antitermination L INFORMATION Transcription -0.92 -0.86 -0.18 -0.12 0.584 factor STORAGE AND PROCESSING EcolC_0530 b3168 infB fused protein chain initiation factor 2, IF2: INFORMATION Translation, -0.74 -0.26 0.02 0.49 0.029 membrane protein/conserved protein STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0531 b3167 rbfA 30s ribosome binding factor INFORMATION Translation, -0.80 -0.70 0.04 0.15 0.148 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0532 b3166 truB tRNA pseudouridine synthase B: tRNA INFORMATION Translation, -0.84 -0.61 0.24 0.46 0.736 pseudouridine(55) synthase and putative STORAGE AND ribosomal tmRNA pseudouridine(342) synthase PROCESSING structure and biogenesis EcolC_0533 b3165 rpsO 30S ribosomal subunit protein S15 INFORMATION Translation, 0.06 0.15 0.39 0.48 0.394 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0535 b3163 nlpI lipoprotein involved in osmotic sensitivity POORLY General -0.43 -0.87 0.17 -0.27 0.335 and filamentation CHARACTERIZ function ED prediction EcolC_0536 b3162 deaD ATP-dependent RNA helicase INFORMATION Replication,l -0.67 -0.07 0.16 0.76 0.026 STORAGE AND recombination PROCESSING and repair EcolC_0538 b3160 yhbW predicted enzyme METABOLISM Energy 1.00 -0.08 0.20 -0.88 0.026 production and conversion EcolC_0539 b3159 yhbV predicted protease CELLULAR Posttranslatio 0.09 0.14 0.30 0.35 0.398 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0540 b3158 yhbU predicted peptidase (collagenase-like) CELLULAR Posttranslatio 0.00 -0.02 0.43 0.40 0.903 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0541 b3157 yhbT predicted lipid carrier protein, COG3154 METABOLISM Lipid -0.88 -0.56 0.05 0.37 0.180 family transport and metabolism EcolC_0542 b3156 yhbS predicted acyltransferase with acyl-CoA N- POORLY General -0.66 -0.15 0.14 0.65 0.001 acyltransferase domain CHARACTERIZ function ED prediction l EcolC_0543 b3155 yhbQ conserved protein, GIY-YIG INFORMATION Replication, -0.44 0.35 0.29 1.08 0.019 superfamily STORAGE AND recombination PROCESSING and repair EcolC_0544 b3154 yhbP conserved protein, UPF0306 family POORLY Function 0.26 0.65 0.33 0.72 0.592 CHARACTERIZ unknown ED EcolC_0545 b3153 yhbO stress-resistance protein POORLY General 0.41 0.83 0.20 0.63 0.869 CHARACTERIZ function ED prediction EcolC_0547 b3151 yraQ predicted permease POORLY Generall 0.08 0.18 0.11 0.21 0.711 CHARACTERIZ function ED prediction EcolC_0548 b3150 yraP outer membrane lipoprotein POORLY Generall -0.22 0.11 -0.12 0.21 0.017 CHARACTERIZ function ED prediction EcolC_0549 b3149 diaA DnaA initiator-associating factor for METABOLISM Carbohydratel 0.12 0.04 0.14 0.06 0.974 replication initiation transport and metabolism EcolC_0550 b3148 yraN conserved protein, UPF0102 family INFORMATION Replication, 0.15 0.24 0.11 0.21 0.153 STORAGE AND recombination PROCESSING and repair EcolC_0551 b3147 lpoA conserved protein POORLY General 0.11 0.09 0.10 0.08 0.587 CHARACTERIZ function ED prediction EcolC_0552 b3146 rsmI 16S rRNA C1402 2'-O-ribose POORLY Generall 0.21 -0.07 0.17 -0.11 0.157 methyltransferase, SAM-dependent CHARACTERIZ function ED prediction EcolC_0553 b3145 yraK predicted fimbrial-like adhesin protein CELLULAR Celll motility -0.09 -0.05 0.16 0.20 0.748 PROCESSES AND SIGNALING EcolC_0554 b3144 yraJ predicted outer membrane protein CELLULAR Cell motility -0.11 -0.10 0.13 0.14 0.571 PROCESSES AND SIGNALING EcolC_0555 b3143 yraI predicted periplasmic pilin chaperone CELLULAR Cell motility 0.04 0.05 0.02 0.02 0.767 PROCESSES AND SIGNALING EcolC_0556 b3142 yraH predicted fimbrial-like adhesin protein CELLULAR Cell motility 0.27 0.31 0.31 0.34 0.670 PROCESSES AND SIGNALING EcolC_0557 b3141 agaI galactosamine-6-phosphate isomerase METABOLISM Carbohydrate -0.46 -0.45 -0.51 -0.50 0.938 transport and metabolism EcolC_0558 b3140 agaD N-acetylgalactosamine-specific enzyme IID METABOLISM Carbohydrate -0.17 -0.04 0.06 0.18 0.484 component of PTS transport and metabolism EcolC_0559 b3139 agaC N-acetylgalactosamine-specific enzyme IIC METABOLISM Carbohydrate -1.07 -0.98 -0.89 -0.81 0.413 component of PTS transport and metabolism EcolC_0560 b3138 agaB N-acetylgalactosamine-specific enzyme IIB METABOLISM Carbohydrate -0.07 -0.02 0.39 0.44 0.323 component of PTS transport and metabolism EcolC_0561 b3137 kbaY tagatose 6-phosphate aldolase 1, kbaY METABOLISM Carbohydrate 0.00 0.03 0.43 0.46 0.625 subunit transport and metabolism EcolC_0562 b3136 agaS tagatose-6-phosphate ketose/aldose CELLULAR Cell -0.82 -0.62 0.09 0.29 0.037 isomerase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0565 - agaE PTS system, N-acetylgalactosamine- METABOLISM Carbohydrate -0.14 0.54 0.43 1.11 0.002 specific IID component transport and metabolism EcolC_0566 b3134 agaW - - - -0.44 0.00 0.43 0.88 0.008 EcolC_0567 b3133 agaV N-acetylgalactosamine-specific enzyme IIB METABOLISM Carbohydrate -0.15 0.12 0.30 0.57 0.111 component of PTS transport and metabolism EcolC_0568 b3132 kbaZ tagatose 6-phosphate aldolase 1, kbaZ METABOLISM Carbohydrate -0.08 0.11 0.16 0.34 0.753 subunit transport and metabolism EcolC_0569 b3131 agaR DNA-binding transcriptional repressor of INFORMATION Transcription -0.18 -0.47 0.14 -0.14 0.417 the aga regulon STORAGE AND PROCESSING EcolC_0570 b3130 yhaV toxin of the SohB(PrlF)-YhaV toxin- - - -0.07 0.16 0.24 0.47 0.535 antitoxin system EcolC_0571 b3129 prlF antitoxin of the SohA(PrlF)-YhaV toxin- INFORMATION Transcription 0.32 0.58 -0.12 0.14 0.484 antitoxin system STORAGE AND PROCESSING EcolC_0572 b3128 garD (D)-galactarate dehydrogenase METABOLISM Carbohydrate -1.52 -0.51 -0.64 0.38 0.032 transport and metabolism EcolC_0573 b3127 garP predicted (D)-galactarate transporter METABOLISM Carbohydrate -2.37 -1.11 -0.46 0.80 0.023 transport and metabolism EcolC_0574 b3126 garL alpha-dehydro-beta-deoxy-D-glucarate METABOLISM Carbohydrate -2.96 -2.17 -0.78 0.00 0.175 aldolase transport and metabolism EcolC_0575 b3125 garR tartronate semialdehyde reductase METABOLISM Lipid -3.10 -3.04 -0.56 -0.50 0.527 transport and metabolism EcolC_0578 b3120 yhaB predicted protein - - 0.06 -0.03 0.07 -0.02 0.555 EcolC_0579 b3119 tdcR DNA-binding transcriptional activator - - -0.14 -0.19 -0.20 -0.26 0.448 EcolC_0580 b3118 tdcA DNA-binding transcriptional activator INFORMATION Transcription 0.58 1.11 0.14 0.67 0.010 STORAGE AND PROCESSING EcolC_0581 b3117 tdcB catabolic threonine dehydratase, PLP- METABOLISM Amino acid 0.08 0.73 0.18 0.83 0.002 dependent transport and metabolism EcolC_0582 b3116 tdcC L-threonine/L-serine transporter METABOLISM Amino acid -0.60 0.95 -0.38 1.16 0.005 transport and metabolism EcolC_0584 b3114 tdcE pyruvate formate-lyase 4/2-ketobutyrate METABOLISM Energy -1.49 1.04 -0.65 1.87 0.001 formate-lyase production and conversion EcolC_0585 b3113 tdcF putative reactive intermediate deaminase INFORMATION Translation, -2.28 0.02 -0.42 1.88 0.002 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0586 b4471 tdcG L-serine dehydratase 3 METABOLISM Amino acid -1.84 0.16 -0.57 1.43 0.002 transport and metabolism EcolC_0587 b3110 yhaO predicted transporter METABOLISM Amino acid -1.00 -0.34 -0.38 0.28 0.036 transport and metabolism EcolC_0588 b4470 yhaM conserved protein POORLY Function 0.42 0.36 0.33 0.27 0.987 CHARACTERIZ unknown ED EcolC_0589 b3107 yhaL predicted protein - - -0.10 0.14 -0.18 0.06 0.483 EcolC_0590 b3106 yhaK redox-sensitive bicupin POORLY General 0.09 0.07 0.17 0.15 0.624 CHARACTERIZ function ED prediction l EcolC_0591 b3105 yhaJ predicted DNA-binding transcriptional INFORMATION Transcription -0.01 0.16 0.09 0.25 0.208 regulator STORAGE AND PROCESSING EcolC_0592 b3104 yhaI inner membrane protein, DUF805 family POORLY Function -0.26 -0.47 -0.31 -0.53 0.173 CHARACTERIZ unknown ED EcolC_0593 b3103 yhaH inner membrane protein, DUF805 family POORLY Function -0.19 -0.48 0.19 -0.10 0.243 CHARACTERIZ unknown ED EcolC_0594 b3102 yqjG predicted S-transferase CELLULAR Posttranslatio -0.40 -0.42 0.07 0.05 0.583 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0595 b3101 yqjF predicted quinol oxidase subunit POORLY Function 0.11 0.15 0.39 0.43 0.788 CHARACTERIZ unknown ED EcolC_0596 b3100 yqjK conserved protein - - -0.04 0.16 0.38 0.58 0.444 EcolC_0597 b3099 yqjE inner membrane protein, DUF1469 family POORLY Function -1.36 -1.32 0.13 0.18 0.940 CHARACTERIZ unknown ED EcolC_0598 b3098 yqjD membrane-anchored ribosome-binding POORLY Function -0.64 -0.42 0.05 0.27 0.126 protein CHARACTERIZ unknown ED EcolC_0599 b3097 yqjC conserved protein - - -1.35 -1.64 0.19 -0.10 0.242 EcolC_0600 b3096 mzrA modulator of EnvZ/OmpR regulon INFORMATION Replication, -0.09 -0.66 0.90 0.33 0.005 STORAGE AND recombination PROCESSING and repair EcolC_0601 b3095 yqjA general envelope maintenance protein POORLY Function -0.45 -0.85 1.67 1.27 0.014 CHARACTERI unknown ZED EcolC_0602 b3094 exuR DNA-binding transcriptional repressor INFORMATIO Transcriptio 0.10 0.32 0.35 0.57 0.742 N STORAGE n AND PROCESSING EcolC_0607 b3093 exuT hexuronate transporter METABOLISM Carbohydrate 0.01 -0.18 0.33 0.14 0.629 transport and metabolism EcolC_0608 b3092 uxaC uronate isomerase METABOLISM Carbohydrate -0.62 -0.49 0.27 0.40 0.475 transport and metabolism EcolC_0609 b3091 uxaA altronate hydrolase METABOLISM Carbohydrate -0.40 -0.71 0.06 -0.26 0.076 transport and metabolism EcolC_0610 b3090 ygjV inner membrane protein, Imp-YgjV family - - -0.04 -0.18 -0.11 -0.25 0.306 EcolC_0611 b3089 sstT sodium:serine/threonine symporter METABOLISM Amino acid 0.21 -0.10 0.11 -0.20 0.270 transport and metabolism EcolC_0612 b3088 alx inner membrane protein, part of terminus METABOLISM Inorganic ion 0.11 0.04 0.24 0.17 0.141 transport and metabolism EcolC_0613 b3087 ygjR predicted NAD(P)-binding dehydrogenase POORLY General -0.22 0.51 -0.13 0.61 0.001 CHARACTERIZ function ED prediction EcolC_0615 b3085 ygjP predicted metal dependent hydrolase POORLY Generall 0.27 0.55 0.05 0.34 0.154 CHARACTERIZ function ED prediction EcolC_0616 b3084 rlmG 23S rRNA m(2)G1835 methyltransferase, INFORMATION Translation,l -0.12 -0.16 -0.17 -0.21 0.830 SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0617 b3083 higB mRNA interferase toxin of the HigB-HigA POORLY Function -0.08 -0.22 -0.21 -0.36 0.625 toxin-antitoxin system CHARACTERIZ unknown ED EcolC_0618 b3082 higA antitoxinof the HigB-HigA toxin-antitoxin INFORMATION Transcription 0.21 -0.06 -0.29 -0.57 0.123 system STORAGE AND PROCESSING EcolC_0619 b3081 fadH 2,4-dienoyl-CoA reductase, NADH and METABOLISM Energy 1.26 0.24 -0.11 -1.12 0.087 FMN-linked production and conversion EcolC_0620 b3080 ygjK alpha-glucosidase METABOLISM Carbohydrate -0.13 -0.23 -0.08 -0.19 0.307 transport and metabolism EcolC_0621 b3079 ygjJ conserved protein - - -0.10 -0.01 0.01 0.10 0.503 EcolC_0622 b3078 ygjI predicted transporter METABOLISM Amino acid -0.12 -0.16 -0.06 -0.11 0.773 transport and metabolism EcolC_0623 b3077 ebgC cryptic beta-D-galactosidase, beta subunit METABOLISM Carbohydrate -0.01 -0.05 -0.12 -0.17 0.588 transport and metabolism EcolC_0624 b3076 ebgA cryptic beta-D-galactosidase, alpha subunit METABOLISM Carbohydrate 0.07 -0.12 0.03 -0.17 0.080 transport and metabolism EcolC_0625 b3075 ebgR DNA-binding transcriptional repressor INFORMATION Transcription -0.05 0.16 0.23 0.44 0.023 STORAGE AND PROCESSING EcolC_0626 b3074 ygjH probable tRNA binding protein; putative POORLY General 0.00 -0.05 0.17 0.12 0.425 tRNA corner chaperone CHARACTERIZ function ED prediction l EcolC_0628 b3072 aer fused signal transducer for aerotaxis CELLULAR Cell motility 0.25 -0.11 0.00 -0.35 0.130 sensory component/methyl accepting PROCESSES chemotaxis component AND SIGNALING EcolC_0629 b3071 yqjI predicted transcriptional regulator, PadR INFORMATION Transcription -0.78 -0.56 -0.15 0.07 0.748 family STORAGE AND PROCESSING EcolC_0630 b3070 yqjH predicted siderophore interacting protein METABOLISM Inorganic ion 0.00 0.08 0.09 0.16 0.604 transport and metabolism EcolC_0631 b3068 mug G/U mismatch-specific DNA glycosylase; INFORMATION Replication, 0.43 -0.13 0.11 -0.45 0.040 xanthine DNA glycosylase STORAGE AND recombination PROCESSING and repair EcolC_0632 b3067 rpoD RNA polymerase, sigma 70 (sigma D) INFORMATION Transcription 0.09 0.07 0.13 0.12 0.829 factor STORAGE AND PROCESSING EcolC_0633 b3066 dnaG DNA INFORMATION Replication, 0.17 -0.09 0.52 0.26 0.036 STORAGE AND recombination PROCESSING and repair EcolC_0634 b3065 rpsU 30S ribosomal subunit protein S21 INFORMATION Translation, -0.57 -0.23 -0.12 0.21 0.099 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0635 b3064 tsaD tRNA(ANN) t(6)A37 CELLULAR Posttranslatio 0.49 0.50 0.61 0.61 0.653 threonylcarbamoyladenosine modification PROCESSES nal protein; glycation binding protein AND modification, SIGNALING protein turnover, chaperones EcolC_0636 b3063 ttdT L-tartrate/succinate antiporte METABOLISM Inorganic ion -0.46 -0.32 -0.27 -0.13 0.751 transport and metabolism EcolC_0637 b3062 ttdB L-tartrate dehydratase, beta subunit METABOLISM Energy 0.09 0.08 0.05 0.03 0.701 production and conversion EcolC_0638 b3061 ttdA L-tartrate dehydratase, alpha subunit METABOLISM Energy -0.04 -0.03 -0.09 -0.08 0.841 production and conversion EcolC_0639 b3060 ttdR transcriptional activator of ttdABT INFORMATION Transcription -0.25 -0.28 0.11 0.07 0.819 STORAGE AND PROCESSING EcolC_0640 b3059 plsY probable glycerol-3-phosphate POORLY Function -0.66 -0.54 0.08 0.20 0.562 acyltransferase CHARACTERIZ unknown ED EcolC_0641 b3058 folB bifunctional dihydroneopterin METABOLISM Coenzyme 0.04 0.20 0.19 0.35 0.344 aldolase/dihydroneopterin triphosphate 2'- transport and epimerase metabolism EcolC_0642 b3057 bacA undecaprenyl pyrophosphate phosphatase CELLULAR Defense -0.06 0.16 -0.10 0.12 0.599 PROCESSES mechanisms AND SIGNALING EcolC_0643 b3056 cca fused tRNA nucleotidyl transferase/2'3'- INFORMATION Translation, 0.31 0.47 -0.03 0.13 0.593 cyclic phosphodiesterase/2'nucleotidase STORAGE AND ribosomal and phosphatase PROCESSING structure and biogenesis EcolC_0644 b3055 ygiM SH3 domain protein CELLULAR Signal 0.52 0.40 0.48 0.36 0.251 PROCESSES transduction AND mechanisms SIGNALING EcolC_0645 b3054 ygiF predicted adenylate cyclase POORLY Function -0.43 -0.20 -0.30 -0.06 0.242 CHARACTERIZ unknown ED EcolC_0646 b3053 glnE fused CELLULAR Posttranslatio -0.69 -0.56 -0.21 -0.07 0.065 deadenylyltransferase/adenylyltransferase PROCESSES nal for glutamine synthetase AND modification, SIGNALING protein turnover, chaperones EcolC_0647 b3052 hldE fused heptose 7-phosphate kinase/heptose CELLULAR Cell -0.50 -0.25 -0.01 0.24 0.020 1-phosphate adenyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0648 b3051 yqiK PHB family membrane protein, function POORLY Function 1.03 0.55 0.34 -0.14 0.112 unknown CHARACTERIZ unknown ED EcolC_0649 b3050 yqiJ inner membrane protein, DUF1449 family - - 0.66 0.40 0.40 0.15 0.117 EcolC_0650 b3049 glgS motility and biofilm regulator - - 1.28 -0.62 -1.23 -3.13 0.008 EcolC_0651 b3048 yqiI conserved protein - - 0.76 -0.03 0.10 -0.69 0.010 EcolC_0654 b3043 ygiL predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.03 -0.09 -0.09 -0.16 0.232 PROCESSES AND SIGNALING EcolC_0655 b3042 yqiC conserved protein POORLY Function -0.63 -0.32 0.02 0.33 0.389 CHARACTERIZ unknown ED EcolC_0658 b3040 zupT zinc transporter METABOLISM Inorganic ion -1.00 0.00 0.73 1.73 0.013 transport and metabolism EcolC_0659 b3039 ygiD predicted dioxygenase, LigB family POORLY Function -0.06 0.06 0.25 0.37 0.376 CHARACTERIZ unknown ED EcolC_0661 b3037 ygiB DUF1190 family protein POORLY Function 0.70 0.06 -0.26 -0.90 0.030 CHARACTERIZ unknown ED EcolC_0662 b3035 tolC transport channel CELLULAR Cell -0.09 -0.65 -0.13 -0.69 0.009 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0663 b3034 nudF ADP-ribose pyrophosphatase INFORMATION Replication, -0.02 0.01 0.21 0.24 0.834 STORAGE AND recombination PROCESSING and repair EcolC_0664 b3033 yqiB DUF1249 protein YqiB POORLY Function 0.30 0.51 0.28 0.50 0.856 CHARACTERIZ unknown ED EcolC_0665 b3032 cpdA 3',5' cAMP phosphodiesterase POORLY General 0.29 0.76 -0.04 0.44 0.007 CHARACTERIZ function ED prediction EcolC_0666 b3031 yqiA acyl CoA POORLY Generall 0.20 0.41 0.06 0.27 0.086 CHARACTERIZ function ED prediction EcolC_0667 b3030 parE DNA topoisomerase IV, subunit B INFORMATION Replication,l 0.79 0.64 0.39 0.24 0.597 STORAGE AND recombination PROCESSING and repair EcolC_0668 b3029 ygiN quinol monooxygenase POORLY Function 0.09 0.22 0.18 0.31 0.120 CHARACTERIZ unknown ED EcolC_0669 b3028 mdaB NADPH quinone reductase POORLY General 0.61 0.35 0.35 0.09 0.163 CHARACTERIZ function ED prediction EcolC_0670 b3027 ygiZ inner membrane protein - -l -0.23 -0.23 -0.05 -0.05 0.379 EcolC_0671 b3026 qseC quorum sensing sensory histidine kinase in CELLULAR Signal 0.00 -0.13 0.35 0.22 0.413 two-component regulatory system with PROCESSES transduction QseB AND mechanisms SIGNALING EcolC_0672 b3025 qseB quorum sensing DNA-binding response CELLULAR Signal -0.01 -0.01 0.31 0.31 0.965 regulator in two-component regulatory PROCESSES transduction system with QseC AND mechanisms SIGNALING EcolC_0673 b3024 ygiW conserved protein POORLY Function 0.27 0.44 0.73 0.90 0.651 CHARACTERIZ unknown ED EcolC_0674 b3023 ygiV transcriptional repressor for mcbR biofilm INFORMATION Replication, 0.18 -0.27 0.20 -0.25 0.346 gene STORAGE AND recombination PROCESSING and repair EcolC_0675 b3022 mqsR GCU-specific mRNA interferase toxin of - - -0.61 -0.45 0.28 0.44 0.305 the MqsR-MqsA toxin-antitoxin system; biofilm/motility regulator; anti-repressor EcolC_0676 b3021 mqsA antitoxin for MqsR toxin; transcriptional INFORMATION Transcription 0.01 -0.03 0.44 0.41 0.997 repressor STORAGE AND PROCESSING EcolC_0677 b3020 ygiS predicted transporter subunit: periplasmic- METABOLISM Amino acid 0.82 0.47 0.24 -0.11 0.071 binding component of ABC superfamily transport and metabolism EcolC_0678 b3019 parC DNA topoisomerase IV, subunit A INFORMATION Replication, 0.30 0.48 0.33 0.52 0.213 STORAGE AND recombination PROCESSING and repair EcolC_0679 b3018 plsC 1-acyl-sn-glycerol-3-phosphate METABOLISM Lipid -0.34 -0.16 -0.05 0.14 0.134 acyltransferase transport and metabolism EcolC_0680 b3017 ftsP septal ring component that protects the METABOLISM Secondary 0.06 0.26 0.00 0.20 0.535 divisome from stress; multicopy suppressor metabolites of ftsI(Ts) biosynthesis, transport and catabolism EcolC_0681 b4469 ygiQ Radical SAM superfamily protein METABOLISM Energy 0.09 0.15 0.09 0.16 0.653 production and conversion EcolC_0682 b3014 yqhH outer membrane lipoprotein, Lpp paralog CELLULAR Cell 0.05 0.19 0.16 0.31 0.469 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0683 b3013 yqhG conserved protein - - 0.04 0.10 0.02 0.08 0.572 EcolC_0684 b3012 dkgA 2,5-diketo-D-gluconate reductase A POORLY General -0.61 -1.09 0.32 -0.17 0.026 CHARACTERIZ function ED prediction EcolC_0685 b3011 yqhD aldehyde reductase, NADPH-dependent METABOLISM Energyl 0.89 0.90 -0.23 -0.23 0.650 production and conversion EcolC_0686 b3010 yqhC transcriptional activator of yqhD INFORMATION Transcription 0.39 0.32 0.26 0.19 0.975 STORAGE AND PROCESSING EcolC_0687 b3009 yghB general envelope maintenance protein POORLY Function 0.69 0.84 0.29 0.43 0.374 CHARACTERIZ unknown ED EcolC_0688 b3008 metC cystathionine beta-lyase, PLP-dependent METABOLISM Amino acid -0.01 0.13 0.37 0.52 0.239 transport and metabolism EcolC_0689 b3006 exbB membrane spanning protein in TonB- CELLULAR Intracellular -0.17 -0.20 0.14 0.11 0.858 ExbB-ExbD complex PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0690 b3005 exbD membrane spanning protein in TonB- CELLULAR Intracellular -0.07 -0.01 0.18 0.25 0.363 ExbB-ExbD complex PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0691 b3003 yghA predicted oxidoreductase METABOLISM Lipid -0.17 0.10 0.10 0.36 0.325 transport and metabolism EcolC_0692 b3002 yqhA predicted inner membrane protein, POORLY Function 0.10 0.45 0.27 0.62 0.046 UPF0114 family CHARACTERIZ unknown ED EcolC_0693 b3001 gpr L-glyceraldehyde 3-phosphate reductase METABOLISM Energy 0.74 1.24 -0.08 0.43 0.013 production and conversion EcolC_0695 b2998 yghW predicted protein - - 0.03 -0.06 0.01 -0.08 0.620 EcolC_0696 b2997 hybO hydrogenase 2, small subunit METABOLISM Energy 0.76 1.52 -0.12 0.65 0.034 production and conversion EcolC_0697 b2996 hybA hydrogenase 2 4Fe-4S ferredoxin-type METABOLISM Energy 1.17 1.39 -0.13 0.08 0.394 component production and conversion EcolC_0698 b2995 hybB predicted hydrogenase 2 cytochrome b type METABOLISM Energy 0.38 1.14 -0.22 0.54 0.002 component production and conversion EcolC_0700 b2993 hybD maturation protease for hydrogenase 2 METABOLISM Energy -0.10 0.79 0.02 0.91 0.001 production and conversion EcolC_0701 b2992 hybE hydrogenase 2-specific chaperone - - -0.15 0.39 -0.05 0.49 0.005 EcolC_0702 b2991 hybF protein involved with the maturation of POORLY General 0.10 0.59 0.12 0.62 0.002 hydrogenases 1 and 2 CHARACTERIZ function ED prediction EcolC_0703 b2990 hybG hydrogenase 2 accessory protein CELLULAR Posttranslatiol 0.11 0.75 0.15 0.78 0.001 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0704 b2989 yghU predicted S-transferase CELLULAR Posttranslatio 0.00 0.21 -0.04 0.16 0.055 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0705 b2988 gss fused glutathionylspermidine METABOLISM Amino acid 0.03 -0.19 0.25 0.03 0.234 amidase/glutathionylspermidine synthetase transport and metabolism EcolC_0706 b2987 pitB phosphate transporter METABOLISM Inorganic ion -0.07 -0.21 -0.06 -0.20 0.646 transport and metabolism EcolC_0707 b2986 yghT predicted ATP-binding protein METABOLISM Nucleotide -0.02 0.01 -0.06 -0.03 0.460 transport and metabolism EcolC_0708 b2985 yghS predicted ATP-binding protein METABOLISM Nucleotide -0.27 -0.30 -0.16 -0.19 0.937 transport and metabolism EcolC_0709 b2984 yghR predicted ATP-binding protein METABOLISM Nucleotide -0.04 -0.04 0.00 0.00 0.931 transport and metabolism EcolC_0710 b2983 yghQ predicted inner membrane protein POORLY General -0.29 -0.25 -0.16 -0.12 0.650 CHARACTERIZ function ED prediction EcolC_0711 - - hypothetical protein - -l 0.05 -0.03 -0.02 -0.10 0.535 EcolC_0712 - - hypothetical protein POORLY General 0.34 0.32 0.70 0.68 0.862 CHARACTERIZ function ED prediction EcolC_0713 - - hypothetical protein POORLY Generall 0.02 0.00 -0.11 -0.13 0.536 CHARACTERIZ function ED prediction EcolC_0714 - - hypothetical protein POORLY Generall 0.09 -0.04 -0.14 -0.27 0.597 CHARACTERIZ function ED prediction EcolC_0715 - - hypothetical protein METABOLISM Coenzymel -0.10 0.08 0.14 0.32 0.544 transport and metabolism EcolC_0716 - - hypothetical protein METABOLISM Lipid 0.12 0.04 0.07 -0.01 0.191 transport and metabolism EcolC_0717 - - hypothetical protein CELLULAR Cell 0.20 -0.03 0.11 -0.12 0.261 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0718 - - acyl-CoA synthetase METABOLISM Lipid -0.08 -0.21 0.13 -0.01 0.295 transport and metabolism EcolC_0719 b2981 yghO - - - 0.21 0.12 0.13 0.04 0.663 EcolC_0720 b2980 glcC DNA-binding transcriptional dual INFORMATION Transcription 0.50 -0.08 0.18 -0.40 0.123 regulator, glycolate-binding STORAGE AND PROCESSING EcolC_0721 b2979 glcD glycolate oxidase subunit, FAD-linked METABOLISM Energy 0.52 0.11 0.04 -0.37 0.268 production and conversion EcolC_0722 b4468 glcE glycolate oxidase FAD binding subunit METABOLISM Energy 1.11 0.55 0.51 -0.05 0.103 production and conversion EcolC_0723 b4467 glcF glycolate oxidase 4Fe-4S iron-sulfur METABOLISM Energy 1.24 0.26 0.08 -0.91 0.042 cluster subunit production and conversion EcolC_0724 b2977 glcG conserved protein POORLY General 2.12 1.44 -0.31 -0.99 0.001 CHARACTERIZ function ED prediction EcolC_0725 b2976 glcB malate synthase G METABOLISM Energyl 2.17 1.10 -0.12 -1.19 0.019 production and conversion EcolC_0726 b2975 glcA glycolate transporter METABOLISM Energy 0.42 -0.04 -0.10 -0.56 0.015 production and conversion EcolC_0735 - yis2 IS600 ORF2-like protein INFORMATION Replication, 0.08 0.47 0.32 0.71 0.263 STORAGE AND recombination PROCESSING and repair EcolC_0738 b4286 yjhV - - - -0.11 -0.11 0.02 0.02 0.708 EcolC_0739 b4287 fecE KpLE2 phage-like element; iron-dicitrate METABOLISM Inorganic ion 0.03 0.09 0.14 0.20 0.877 transporter subunit transport and metabolism EcolC_0740 b4288 fecD KpLE2 phage-like element; iron-dicitrate METABOLISM Inorganic ion -0.16 -0.20 -0.01 -0.04 0.938 transporter subunit transport and metabolism EcolC_0741 b4289 fecC KpLE2 phage-like element; iron-dicitrate METABOLISM Inorganic ion -0.05 -0.10 -0.05 -0.10 0.738 transporter subunit transport and metabolism EcolC_0742 b4290 fecB KpLE2 phage-like element; iron-dicitrate METABOLISM Inorganic ion 0.50 0.23 0.24 -0.03 0.270 transporter subunit transport and metabolism EcolC_0743 b4291 fecA KpLE2 phage-like element; ferric citrate METABOLISM Inorganic ion 0.46 0.30 0.04 -0.12 0.970 outer membrane transporter transport and metabolism EcolC_0744 b4292 fecR KpLE2 phage-like element; transmembrane METABOLISM Inorganic ion 0.13 0.29 0.04 0.20 0.714 signal transducer for ferric citrate transport transport and metabolism EcolC_0745 b4293 fecI KpLE2 phage-like element; RNA INFORMATION Transcription -0.18 0.12 0.04 0.34 0.272 polymerase, sigma 19 factor STORAGE AND PROCESSING EcolC_0748 b2966 yqgA predicted inner membrane protein, POORLY General 0.04 0.02 0.21 0.19 0.929 DUF554 family CHARACTERIZ function ED prediction EcolC_0749 b2965 speC ornithine decarboxylase, constitutive METABOLISM Aminol acid -0.30 -0.38 -0.38 -0.45 0.713 transport and metabolism EcolC_0750 b2964 nupG nucleoside transporter METABOLISM Carbohydrate 1.51 0.67 -0.32 -1.16 0.005 transport and metabolism EcolC_0751 b2963 mltC membrane-bound lytic murein CELLULAR Cell 0.21 0.14 0.18 0.11 0.625 transglycosylase C PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0752 b2962 yggX protein that protects iron-sulfur proteins METABOLISM Energy -0.03 0.20 0.02 0.25 0.597 against oxidative damage production and conversion EcolC_0753 b2961 mutY adenine DNA glycosylase INFORMATION Replication, -0.29 0.02 -0.06 0.25 0.599 STORAGE AND recombination PROCESSING and repair EcolC_0754 b2960 trmI tRNA m(7)G46 methyltransferase, SAM- POORLY General -0.86 -0.63 0.08 0.31 0.043 dependent CHARACTERIZ function ED prediction EcolC_0755 b2959 yggL conserved protein, DUF469 family POORLY Functionl -0.22 0.07 0.29 0.58 0.048 CHARACTERIZ unknown ED EcolC_0756 b2958 yggN predicted protein - - -0.54 -0.45 0.35 0.44 0.888 EcolC_0757 b2957 ansB periplasmic L-asparaginase II METABOLISM Amino acid -3.09 -2.23 -0.12 0.74 0.040 transport and metabolism EcolC_0758 b2956 yggM conserved protein - - 0.08 0.06 0.43 0.41 0.753 EcolC_0760 b2954 rdgB dITP/XTP pyrophosphatase METABOLISM Nucleotide 0.53 0.39 0.18 0.05 0.663 transport and metabolism EcolC_0761 b2953 yggU conserved protein, UPF0235 family POORLY Function 0.56 0.28 0.24 -0.04 0.050 CHARACTERIZ unknown ED EcolC_0762 b2952 yggT predicted inner membrane protein - - 0.21 0.10 -0.03 -0.14 0.965 EcolC_0763 b2951 yggS predicted enzyme, binds pyridoxal 5'- POORLY General 0.38 0.08 0.34 0.03 0.193 phosphate CHARACTERIZ function ED prediction EcolC_0764 b2950 yggR predicted pilus retraction ATPase CELLULAR Celll motility 0.13 0.06 0.32 0.25 0.372 PROCESSES AND SIGNALING EcolC_0765 b2949 yqgF predicted resolvase INFORMATION Replication, 0.57 0.22 0.37 0.02 0.305 STORAGE AND recombination PROCESSING and repair EcolC_0766 b2948 yqgE predicted protein INFORMATION Transcription 0.46 0.18 0.14 -0.14 0.289 STORAGE AND PROCESSING EcolC_0767 b2947 gshB glutathione synthetase METABOLISM Coenzyme 0.40 -0.07 -0.03 -0.49 0.066 transport and metabolism EcolC_0768 b2946 rsmE 16S rRNA m(3)U1498 methyltransferase, POORLY Function 0.12 -0.12 -0.28 -0.52 0.129 SAM-dependent CHARACTERIZ unknown ED EcolC_0769 b2945 endA DNA-specific I INFORMATION Replication, -0.07 0.18 0.22 0.47 0.251 STORAGE AND recombination PROCESSING and repair EcolC_0770 b2944 yggI conserved protein POORLY Function 0.19 0.01 0.08 -0.10 0.077 CHARACTERIZ unknown ED EcolC_0771 b2943 galP D-galactose transporter METABOLISM Carbohydrate -0.05 -0.10 0.53 0.48 0.768 transport and metabolism EcolC_0772 b2942 metK S-adenosylmethionine synthetase METABOLISM Coenzyme -0.23 0.12 -0.01 0.33 0.283 transport and metabolism EcolC_0773 b2938 speA biosynthetic arginine decarboxylase, PLP- METABOLISM Amino acid -0.04 -0.13 0.10 0.01 0.625 binding transport and metabolism EcolC_0774 b2937 speB agmatinase METABOLISM Amino acid -0.05 0.09 0.06 0.20 0.680 transport and metabolism EcolC_0776 b2935 tktA transketolase 1, thiamin-binding METABOLISM Carbohydrate 0.30 0.72 0.56 0.99 0.570 transport and metabolism EcolC_0777 b2934 cmtB predicted mannitol-specific enzyme IIA METABOLISM Carbohydrate 0.05 -0.02 -0.17 -0.24 0.861 component of PTS transport and metabolism EcolC_0778 b2933 cmtA predicted fused mannitol-specific PTS METABOLISM Carbohydrate 0.00 0.43 0.05 0.48 0.279 enzymes: IIB component/IIC component transport and metabolism EcolC_0779 b4465 yggP predicted dehydrogenase METABOLISM Amino acid -0.16 -0.29 -0.24 -0.37 0.927 transport and metabolism EcolC_0780 b2930 yggF fructose 1,6 bisphosphatase isozyme METABOLISM Carbohydrate 0.20 0.15 0.21 0.16 0.922 transport and metabolism EcolC_0781 b2929 yggD predicted DNA-binding transcriptional INFORMATION Transcription -0.15 0.08 0.01 0.25 0.099 regulator STORAGE AND PROCESSING EcolC_0782 b2928 yggC conserved protein with nucleoside METABOLISM Coenzyme 0.25 0.62 0.23 0.61 0.174 triphosphate hydrolase domain transport and metabolism EcolC_0783 b2927 epd D-erythrose 4-phosphate dehydrogenase METABOLISM Carbohydrate -0.41 -0.11 0.08 0.38 0.018 transport and metabolism EcolC_0784 b2926 pgk METABOLISM Carbohydrate 0.55 0.69 -0.07 0.06 0.843 transport and metabolism EcolC_0785 b2925 fbaA fructose-bisphosphate aldolase, class II METABOLISM Carbohydrate 0.02 0.37 -0.22 0.14 0.053 transport and metabolism EcolC_0786 b2924 mscS mechanosensitive channel protein, small CELLULAR Cell -0.19 -0.36 -0.13 -0.31 0.347 conductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0787 b2923 argO arginine transporter POORLY General -0.09 -0.13 0.08 0.04 0.307 CHARACTERIZ function ED prediction EcolC_0788 b2922 yggE oxidative stress defense protein POORLY Functionl 0.11 0.02 0.24 0.14 0.878 CHARACTERIZ unknown ED EcolC_0789 b2921 ygfI predicted DNA-binding transcriptional INFORMATION Transcription 0.30 0.69 0.31 0.70 0.167 regulator STORAGE AND PROCESSING EcolC_0790 b2920 scpC propionyl-CoA:succinate CoA transferase METABOLISM Energy 0.37 0.70 0.57 0.90 0.688 production and conversion EcolC_0791 b2919 scpB methylmalonyl-CoA decarboxylase, biotin- METABOLISM Lipid -0.14 -0.14 -0.03 -0.03 0.471 independent transport and metabolism EcolC_0792 b2918 argK membrane ATPase/protein kinase METABOLISM Amino acid -0.03 -0.09 0.23 0.17 0.767 transport and metabolism EcolC_0793 b2917 scpA methylmalonyl-CoA mutase METABOLISM Lipid 0.18 0.48 0.37 0.68 0.946 transport and metabolism EcolC_0794 b2916 argP DNA-binding transcriptional activator, INFORMATION Transcription 0.46 0.60 0.37 0.51 0.427 replication initiation inhibitor STORAGE AND PROCESSING EcolC_0795 b2915 yqfE - - - 0.12 0.13 0.41 0.42 0.416 EcolC_0796 b2914 rpiA ribose 5-phosphate isomerase, constitutive METABOLISM Carbohydrate 0.08 0.56 -0.01 0.47 0.023 transport and metabolism EcolC_0797 b2913 serA D-3-phosphoglycerate dehydrogenase METABOLISM Coenzyme -0.91 -0.55 -0.27 0.10 0.135 transport and metabolism EcolC_0798 b2912 fau conserved protein, 5- METABOLISM Coenzyme 0.22 0.44 0.34 0.56 0.225 formyltetrahydrofolate cyclo-ligase family transport and metabolism EcolC_0799 b2910 zapA FtsZ stabilizer POORLY Function -0.11 0.01 0.23 0.34 0.852 CHARACTERIZ unknown ED EcolC_0800 b2909 ygfB conserved protein, UPF0149 family POORLY Function 0.55 0.34 -0.26 -0.47 0.239 CHARACTERIZ unknown ED EcolC_0801 b2908 pepP proline aminopeptidase P II METABOLISM Amino acid 0.20 0.57 -0.32 0.04 0.145 transport and metabolism EcolC_0802 b2907 ubiH 2-octaprenyl-6-methoxyphenol METABOLISM Coenzyme -0.03 0.19 -0.12 0.11 0.018 hydroxylase, FAD/NAD(P)-binding transport and metabolism EcolC_0803 b2906 visC predicted oxidoreductase with METABOLISM Coenzyme 0.06 0.16 0.14 0.24 0.793 FAD/NAD(P)-binding domain transport and metabolism EcolC_0804 b2905 gcvT aminomethyltransferase, tetrahydrofolate- METABOLISM Amino acid -1.74 -1.31 -0.35 0.09 0.014 dependent, subunit (T protein) of glycine transport and cleavage complex metabolism EcolC_0805 b2904 gcvH glycine cleavage complex lipoylprotein METABOLISM Amino acid -1.37 -1.81 -0.18 -0.62 0.089 transport and metabolism EcolC_0806 b2903 gcvP glycine decarboxylase, PLP-dependent, METABOLISM Amino acid -1.61 -1.17 -0.28 0.17 0.039 subunit (protein P) of glycine cleavage transport and complex metabolism EcolC_0807 b2902 ygfF predicted NAD(P)-binding oxidoreductase METABOLISM Lipid -0.37 -0.15 0.02 0.23 0.184 with NAD(P)-binding Rossmann-fold transport and domain metabolism EcolC_0808 b2901 bglA 6-phospho-beta-glucosidase A METABOLISM Carbohydrate 0.48 0.19 -0.06 -0.35 0.297 transport and metabolism EcolC_0809 b2900 yqfB conserved protein, UPF0267 family POORLY Function 0.40 0.02 0.10 -0.28 0.020 CHARACTERIZ unknown ED EcolC_0810 b2899 yqfA inner membrane protein, hemolysin III POORLY General 0.49 -0.63 0.35 -0.78 0.015 family HylIII CHARACTERIZ function ED prediction EcolC_0812 b2897 sdhE flavinator of succinate dehydrogenase; POORLY Functionl 1.12 1.60 0.01 0.50 0.002 antitoxin of CptAB toxin-antitoxin pair CHARACTERIZ unknown ED EcolC_0813 b2896 cptA toxin of CptAB toxin-antitoxin pair - - 1.19 1.18 0.04 0.02 0.625 EcolC_0814 b2895 fldB flavodoxin 2 METABOLISM Energy 0.69 1.04 0.25 0.59 0.068 production and conversion EcolC_0815 b2894 xerD site-specific tyrosine recombinase INFORMATION Replication, 0.44 0.54 0.07 0.16 0.836 STORAGE AND recombination PROCESSING and repair EcolC_0816 b2893 dsbC protein disulfide isomerase II CELLULAR Posttranslatio 0.26 0.17 0.15 0.06 0.910 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0817 b2892 recJ ssDNA , 5' --> 3'-specific INFORMATION Replication, 0.06 0.19 0.04 0.17 0.487 STORAGE AND recombination PROCESSING and repair EcolC_0818 b2891 prfB peptide chain release factor RF-2 INFORMATION Translation, -0.48 -0.08 -0.33 0.07 0.027 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0819 b2890 lysS lysine tRNA synthetase, constitutive INFORMATION Translation, 0.35 0.59 0.36 0.59 0.047 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0820 b2889 idi isopentenyl diphosphate isomerase METABOLISM Lipid 0.60 0.47 0.38 0.25 0.399 transport and metabolism EcolC_0821 b2888 uacT uric acid permease METABOLISM Nucleotide -0.55 0.59 0.47 1.62 0.003 transport and metabolism EcolC_0822 b2887 ygfT fused predicted oxidoreductase: Fe-S METABOLISM Amino acid -0.52 -0.36 0.50 0.67 0.626 subunit/nucleotide-binding subunit transport and metabolism EcolC_0823 b2886 ygfS predicted oxidoreductase, 4Fe-4S METABOLISM Energy -0.42 -0.18 0.86 1.10 0.469 ferredoxin-type subunit production and conversion EcolC_0824 b4464 ygfQ predicted purine permease POORLY General -0.04 0.04 0.31 0.39 0.663 CHARACTERIZ function ED prediction EcolC_0825 b2883 guaD guanine deaminase METABOLISM Nucleotidel -0.14 0.20 0.70 1.04 0.051 transport and metabolism EcolC_0827 b2881 xdhD probable hypoxanthine oxidase, METABOLISM Energy -0.85 1.51 1.13 3.49 0.004 molybdopterin-binding/Fe-S binding production and conversion EcolC_0828 b2880 ygfM predicted oxidoreductase METABOLISM Energy -0.33 1.79 0.89 3.02 0.001 production and conversion EcolC_0829 b2879 ssnA predicted chlorohydrolase/aminohydrolase METABOLISM Nucleotide -1.26 -0.12 0.59 1.72 0.005 transport and metabolism EcolC_0830 b2878 ygfK predicted oxidoreductase, Fe-S subunit METABOLISM Amino acid -0.90 -0.13 0.51 1.28 0.005 transport and metabolism EcolC_0831 b2877 mocA CTP:molybdopterin cytidylyltransferase POORLY General -0.80 -1.03 0.47 0.25 0.321 CHARACTERIZ function ED prediction EcolC_0832 b2876 yqeC conserved protein METABOLISM Coenzymel 0.27 -0.18 0.65 0.20 0.192 transport and metabolism EcolC_0833 b2875 yqeB conserved protein with NAD(P)-binding CELLULAR Posttranslatio -0.40 -0.45 0.38 0.32 0.990 Rossman fold PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0834 b2874 yqeA predicted amino acid kinase METABOLISM Amino acid -0.42 -0.60 -0.44 -0.62 0.328 transport and metabolism EcolC_0835 b2873 hyuA D-stereospecific phenylhydantoinase METABOLISM Nucleotide -0.37 -0.38 1.10 1.09 0.771 transport and metabolism EcolC_0836 b2872 ygeY predicted peptidase METABOLISM Amino acid -0.82 -0.05 1.28 2.06 0.021 transport and metabolism EcolC_0837 b2871 ygeX 2,3-diaminopropionate ammonia lyase, METABOLISM Amino acid -0.70 -0.04 1.08 1.74 0.047 PLP-dependent transport and metabolism EcolC_0838 b2870 ygeW predicted carbamoyltransferase METABOLISM Amino acid -0.87 -0.01 0.71 1.57 0.003 transport and metabolism EcolC_0839 b2869 ygeV predicted DNA-binding transcriptional INFORMATION Transcription 1.35 0.56 0.22 -0.57 0.011 regulator STORAGE AND PROCESSING EcolC_0840 b2868 xdhC xanthine dehydrogenase, Fe-S binding METABOLISM Energy 0.34 0.68 0.46 0.80 0.030 subunit production and conversion EcolC_0841 b2867 xdhB xanthine dehydrogenase, FAD-binding METABOLISM Energy -0.03 1.38 0.86 2.27 0.011 subunit production and conversion EcolC_0842 b2866 xdhA xanthine dehydrogenase, molybdenum METABOLISM Energy 0.51 2.35 0.89 2.73 0.008 binding subunit production and conversion EcolC_0843 b2865 ygeR novel lipoprotein involved in septation CELLULAR Cell 0.25 0.31 0.36 0.41 0.972 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0844 b2863 ygeQ - - - -0.12 -0.78 -0.22 -0.88 0.047 EcolC_0859 b2856 ygeK - - - -0.20 -0.12 -0.18 -0.09 0.945 EcolC_0860 b2854 pbl - - - -0.16 -0.10 -0.16 -0.09 0.946 EcolC_0861 b2853 ygeI predicted protein - - -0.05 -0.04 0.08 0.10 0.691 EcolC_0862 b2852 ygeH predictedtranscriptional regulator INFORMATION Transcription -0.34 -0.09 -0.17 0.08 0.766 STORAGE AND PROCESSING EcolC_0863 b2851 ygeG predicted chaperone - - -0.06 -0.01 -0.24 -0.19 0.983 EcolC_0864 b2850 ygeF - - - 0.20 0.10 -0.01 -0.11 0.228 EcolC_0866 b2849 yqeK predicted protein - - -0.15 -0.09 -0.20 -0.13 0.929 EcolC_0867 b2848 yqeJ predicted protein - - -0.06 0.08 -0.10 0.03 0.879 EcolC_0868 b2847 yqeI predicted transcriptional regulator INFORMATION Transcription 0.04 0.35 -0.10 0.21 0.732 STORAGE AND PROCESSING EcolC_0869 b2846 yqeH conserved protein with bipartite regulator INFORMATION Transcription -2.53 -2.47 -2.76 -2.70 0.959 domain STORAGE AND PROCESSING EcolC_0870 b2845 yqeG predicted transporter METABOLISM Amino acid -1.13 -1.27 -1.06 -1.20 0.648 transport and metabolism EcolC_0871 b2844 yqeF predicted acyltransferase METABOLISM Lipid 0.76 0.41 -0.01 -0.35 0.340 transport and metabolism EcolC_0872 b2843 kduI putative 5-keto-4-deoxyuronate isomerase; METABOLISM Carbohydrate 0.29 0.30 0.35 0.37 0.952 hexuronate utilization in high osmolarity transport and metabolism EcolC_0873 b2842 kduD putative 2-deoxy-D-gluconate 3- METABOLISM Lipid 0.04 0.06 -0.04 -0.03 0.865 dehydrogenase; hexuronate utilization in transport and high osmolarity metabolism EcolC_0874 b2841 araE arabinose transporter METABOLISM Carbohydrate 0.12 0.02 0.30 0.21 0.644 transport and metabolism EcolC_0875 b2840 ygeA conserved protein, Asp/Glu_racemase CELLULAR Cell 0.17 0.24 0.24 0.31 0.473 family PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0876 b2839 lysR DNA-binding transcriptional dual regulator INFORMATION Transcription 0.14 0.17 0.16 0.19 0.962 STORAGE AND PROCESSING EcolC_0877 b2838 lysA diaminopimelate decarboxylase, PLP- METABOLISM Amino acid 0.20 0.38 0.37 0.55 0.047 binding transport and metabolism EcolC_0878 b2837 galR DNA-binding transcriptional repressor INFORMATION Transcription 0.31 0.44 0.43 0.56 0.635 STORAGE AND PROCESSING EcolC_0879 b2836 aas fused 2-acylglycerophospho-ethanolamine METABOLISM Lipid 0.13 0.24 0.22 0.32 0.532 acyl transferase/acyl-acyl carrier protein transport and synthetase metabolism EcolC_0880 b2835 lplT lysophospholipid transporter - - -0.09 -0.10 0.09 0.08 0.650 EcolC_0881 b2834 tas predicted oxidoreductase, NADP(H)- METABOLISM Energy -0.34 -0.17 -0.01 0.16 0.339 dependent aldo-keto reductase; suppresses production tyrosine requirement of tyrA14 O6 strain and conversion EcolC_0882 b2833 ygdR novel lipoprotein - - 0.26 0.30 0.36 0.40 0.834 EcolC_0883 b2832 ygdQ inner membrane protein, UPF0053 family METABOLISM Inorganic ion 0.05 0.22 0.16 0.33 0.351 transport and metabolism EcolC_0884 b2831 mutH methyl-directed mismatch repair protein INFORMATION Replication, 0.44 0.31 0.08 -0.04 0.527 STORAGE AND recombination PROCESSING and repair EcolC_0885 b2830 rppH RNA pyrophosphohydrolase INFORMATION Replication, 0.58 -0.30 -0.01 -0.89 0.022 STORAGE AND recombination PROCESSING and repair EcolC_0886 b2829 ptsP fused PTS enzyme: PEP-protein CELLULAR Signal 0.57 0.45 0.20 0.08 0.576 phosphotransferase (enzyme I)/GAF PROCESSES transduction domain containing protein AND mechanisms SIGNALING EcolC_0887 b2828 lgt phosphatidylglycerol-prolipoprotein CELLULAR Cell -0.49 -0.36 -0.20 -0.08 0.038 diacylglyceryl transferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0888 b2827 thyA thymidylate synthetase METABOLISM Nucleotide 0.04 0.24 0.14 0.34 0.776 transport and metabolism EcolC_0889 b2826 ppdA conserved protein CELLULAR Cell motility 0.04 0.12 0.02 0.10 0.385 PROCESSES AND SIGNALING EcolC_0890 b2825 ppdB conserved protein CELLULAR Intracellular 0.09 0.03 0.12 0.06 0.589 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_0891 b2824 ygdB conserved protein, DUF2509 family - - 0.23 0.25 0.30 0.33 0.529 EcolC_0892 b2823 ppdC predicted protein CELLULAR Cell motility -0.17 0.33 0.26 0.76 0.091 PROCESSES AND SIGNALING EcolC_0893 b2822 recC exonuclease V (RecBCD complex), gamma INFORMATION Replication, 0.30 0.13 0.10 -0.06 0.600 chain STORAGE AND recombination PROCESSING and repair EcolC_0894 b2821 ptrA protease III CELLULAR Posttranslatio 0.15 -0.10 0.29 0.04 0.416 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0895 b2820 recB exonuclease V (RecBCD complex), beta INFORMATION Replication, 0.41 0.28 0.22 0.09 0.589 subunit STORAGE AND recombination PROCESSING and repair EcolC_0896 b2819 recD exonuclease V (RecBCD complex), alpha INFORMATION Replication, 0.14 -0.05 0.23 0.03 0.903 chain STORAGE AND recombination PROCESSING and repair EcolC_0897 b2818 argA fused acetylglutamate kinase homolog METABOLISM Amino acid 0.13 0.00 0.07 -0.06 0.583 (inactive)/amino acid N-acetyltransferase transport and metabolism EcolC_0898 b2817 amiC N-acetylmuramoyl-L-alanine amidase CELLULAR Cell 0.54 0.30 0.28 0.04 0.220 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0899 b2813 mltA membrane-bound lytic murein CELLULAR Cell 0.29 0.27 0.21 0.19 0.817 transglycosylase A PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0900 b2812 tcdA tRNA threonylcarbamoyladenosine METABOLISM Coenzyme 0.36 0.28 0.34 0.26 0.175 dehydratase; sulfur acceptor for CsdA transport and metabolism EcolC_0901 b2811 csdE CsdA-binding activator; Fe-S protein POORLY General 0.27 0.42 0.19 0.35 0.603 CHARACTERIZ function ED prediction EcolC_0902 b2810 csdA cysteine sulfinate desulfinase METABOLISM Aminol acid 0.46 0.16 0.06 -0.23 0.246 transport and metabolism EcolC_0903 b2809 ygdI novel lipoprotein - - 0.87 0.70 0.59 0.42 0.778 EcolC_0904 b2808 gcvA DNA-binding transcriptional dual regulator INFORMATION Transcription 0.99 0.92 0.49 0.42 0.606 STORAGE AND PROCESSING EcolC_0905 b2807 ygdD inner membrane protein, UPF0382 family POORLY Function 0.30 0.40 0.17 0.27 0.952 CHARACTERIZ unknown ED EcolC_0906 b2806 rlmM 23S rRNA C2498 2'-O-ribose POORLY General 0.77 0.49 0.44 0.16 0.011 methyltransferase, SAM-dependent CHARACTERIZ function ED prediction EcolC_0908 b2804 fucU L-fucose mutarotase METABOLISM Carbohydratel 0.34 0.60 0.01 0.27 0.044 transport and metabolism EcolC_0910 b2802 fucI L-fucose isomerase METABOLISM Carbohydrate 0.95 1.27 -0.03 0.29 0.039 transport and metabolism EcolC_0911 b2801 fucP L-fucose transporter METABOLISM Carbohydrate 1.28 1.10 0.40 0.22 0.496 transport and metabolism EcolC_0912 b2800 fucA L-fuculose-1-phosphate aldolase METABOLISM Carbohydrate -0.37 -0.26 -0.14 -0.03 0.160 transport and metabolism EcolC_0913 b2799 fucO L-1,2-propanediol oxidoreductase METABOLISM Energy -0.93 -0.47 -0.24 0.21 0.132 production and conversion EcolC_0914 b2798 ygdG Ssb-binding protein, misidentified as INFORMATION Replication, 0.07 0.08 -0.13 -0.12 0.686 ExoIX STORAGE AND recombination PROCESSING and repair EcolC_0915 b2797 sdaB L-serine deaminase II METABOLISM Amino acid 0.10 0.03 0.38 0.32 0.776 transport and metabolism EcolC_0916 b2796 sdaC predicted serine transporter METABOLISM Amino acid -0.19 0.05 0.01 0.25 0.220 transport and metabolism EcolC_0917 b2795 ygdH conserved protein, UPF0717 family POORLY General 0.13 0.30 -0.03 0.14 0.406 CHARACTERIZ function ED prediction EcolC_0918 b2794 queF 7-cyano-7-deazaguanine reductase POORLY Functionl 0.26 0.48 -0.03 0.19 0.808 (NADPH-dependent) CHARACTERIZ unknown ED EcolC_0919 b2793 syd SecY-interacting protein - - 0.26 0.51 0.37 0.63 0.552 EcolC_0920 b2792 yqcC conserved protein POORLY Function 0.28 0.56 0.29 0.57 0.594 CHARACTERIZ unknown ED EcolC_0921 b2791 truC tRNA(Ile1,Asp) pseudouridine(65) INFORMATION Translation, 0.35 0.49 0.27 0.41 0.341 synthase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0922 b2790 yqcA predicted METABOLISM Energy 0.18 0.38 0.18 0.39 0.535 production and conversion EcolC_0923 b2789 gudP predicted D-glucarate transporter METABOLISM Carbohydrate -1.54 -0.90 -0.79 -0.15 0.068 transport and metabolism EcolC_0924 b2788 gudX glucarate dehydratase-related protein, CELLULAR Cell -0.84 -0.16 -0.41 0.27 0.207 unknown PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0925 b2787 gudD (D)-glucarate dehydratase 1 CELLULAR Cell -1.40 -0.77 -0.43 0.21 0.234 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0926 b2786 barA hybrid sensory histidine kinase, in two- - - 0.26 0.37 0.17 0.28 0.652 component regulatory system with UvrY EcolC_0927 b2785 rlmD 23S rRNA m(5)U1939 methyltransferase, INFORMATION Translation, 0.30 0.32 0.18 0.20 0.767 SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_0928 b2784 relA (p)ppGpp synthetase I/GTP CELLULAR Signal 0.28 0.22 -0.06 -0.12 0.621 pyrophosphokinase PROCESSES transduction AND mechanisms SIGNALING EcolC_0929 b2783 mazE antitoxin of the ChpA-ChpR toxin- CELLULAR Signal 0.15 0.41 -0.02 0.25 0.060 antitoxin system PROCESSES transduction AND mechanisms SIGNALING EcolC_0930 b2782 mazF mRNA interferase toxin, antitoxin is MazE CELLULAR Signal 0.02 0.48 -0.08 0.37 0.040 PROCESSES transduction AND mechanisms SIGNALING EcolC_0931 b2781 mazG nucleoside triphosphate POORLY General 0.18 0.44 0.14 0.40 0.004 pyrophosphohydrolase CHARACTERIZ function ED prediction EcolC_0932 b2780 pyrG CTP synthetase METABOLISM Nucleotidel -0.23 -0.10 -0.01 0.13 0.653 transport and metabolism EcolC_0933 b2779 eno enolase METABOLISM Carbohydrate -1.46 -0.53 0.01 0.94 0.043 transport and metabolism EcolC_0934 b2778 ygcG predicted protein POORLY General -0.10 -0.18 -0.09 -0.16 0.680 CHARACTERIZ function ED prediction EcolC_0937 b2776 ygcE predicted kinase METABOLISM Carbohydratel 0.51 0.45 0.22 0.16 0.527 transport and metabolism EcolC_0938 b2775 yqcE inner membrane protein, predicted METABOLISM Inorganic ion 0.00 -0.13 -0.21 -0.34 0.540 transporter transport and metabolism EcolC_0939 b2774 ygcW predicted dehydrogenase METABOLISM Lipid 0.01 -0.04 0.05 0.00 0.566 transport and metabolism EcolC_0940 b4463 ygcU predicted FAD containing dehydrogenase METABOLISM Energy -0.02 -0.03 0.05 0.04 0.854 production and conversion EcolC_0941 b2771 ygcS predicted transporter - - 0.03 -0.12 -0.06 -0.21 0.258 EcolC_0942 b2770 ygcR predicted flavoprotein METABOLISM Energy -0.05 0.04 0.00 0.09 0.931 production and conversion EcolC_0943 b2769 ygcQ predicted flavoprotein METABOLISM Energy 0.19 0.20 0.19 0.20 0.842 production and conversion EcolC_0944 b2768 ygcP predicted anti-terminator regulatory protein INFORMATION Transcription 0.67 0.49 0.07 -0.11 0.218 STORAGE AND PROCESSING EcolC_0945 b2767 ygcO predicted 4Fe-4S cluster-containing protein METABOLISM Energy 0.74 0.65 0.00 -0.09 0.575 production and conversion EcolC_0946 b2766 ygcN predicted oxidoreductase with METABOLISM Energy 1.18 0.82 0.09 -0.28 0.312 FAD/NAD(P)-binding domain production and conversion EcolC_0948 b2764 cysJ sulfite reductase, alpha subunit, METABOLISM Inorganic ion 0.22 0.17 0.19 0.14 0.947 flavoprotein transport and metabolism EcolC_0949 b2763 cysI sulfite reductase, beta subunit, NAD(P)- METABOLISM Inorganic ion 0.00 -0.01 0.03 0.03 0.900 binding, heme-binding transport and metabolism EcolC_0950 b2762 cysH 3'-phosphoadenosine 5'-phosphosulfate METABOLISM Amino acid -0.08 -0.14 -0.08 -0.15 0.429 reductase transport and metabolism EcolC_0951 b2761 ygcB R-loop helicase-annealase Cas3 needed for POORLY General 1.06 1.83 0.06 0.83 0.742 Cascade anti-viral activity CHARACTERIZ function ED prediction EcolC_0953 b2759 casB CRISP RNA (crRNA) containing Cascade - -l 0.06 -0.04 -0.13 -0.23 0.896 antiviral complex protein EcolC_0955 b2757 casD CRISP RNA (crRNA) containing Cascade - - 0.08 0.12 -0.08 -0.05 0.917 antiviral complex protein EcolC_0956 b2756 casE CRISPR RNA precursor cleavage enzyme; - - -0.02 0.06 0.10 0.19 0.894 CRISP RNA (crRNA) containing Cascade antiviral complex protein EcolC_0957 b2755 ygbT multifunctional endonuclease Cas1, INFORMATION Replication, -0.06 0.12 0.26 0.44 0.822 CRISPR adaptation protein; DNA repair STORAGE AND recombination enzyme PROCESSING and repair EcolC_0958 b2754 ygbF predicted ssRNA endonuclease Cas2, - - -0.02 0.24 0.29 0.55 0.930 CRISPR adaptation protein EcolC_0959 b2753 iap aminopeptidase in POORLY General 0.04 -0.10 0.25 0.11 0.563 isozyme conversion CHARACTERIZ function ED prediction EcolC_0960 b2752 cysD sulfate adenylyltransferase, subunit 2 METABOLISM Aminol acid 0.00 -0.08 0.31 0.23 0.838 transport and metabolism EcolC_0962 b2750 cysC adenosine 5'-phosphosulfate kinase METABOLISM Inorganic ion -0.17 -0.17 -0.18 -0.18 0.565 transport and metabolism EcolC_0963 b2749 ygbE DUF3561 family inner membrane protein - - -0.37 -0.53 -0.50 -0.65 0.116 EcolC_0964 b2748 ftsB cell division protein CELLULAR Cell cycle 0.04 -0.15 -0.01 -0.20 0.208 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_0965 b2747 ispD 4-diphosphocytidyl-2C-methyl-D-erythritol METABOLISM Lipid 0.08 -0.24 -0.16 -0.47 0.268 synthase transport and metabolism EcolC_0966 b2746 ispF 2C-methyl-D-erythritol 2,4- METABOLISM Lipid 0.29 0.18 -0.01 -0.12 0.515 cyclodiphosphate synthase transport and metabolism EcolC_0967 b2745 truD tRNA(Glu) pseudouridine(13) synthase POORLY Function 0.62 0.12 -0.10 -0.59 0.149 CHARACTERIZ unknown ED EcolC_0968 b2744 surE broad specificity 5'(3')-nucleotidase and POORLY General 0.50 -0.18 -0.13 -0.81 0.006 polyphosphatase CHARACTERIZ function ED prediction EcolC_0969 b2743 pcm L-isoaspartate protein CELLULAR Posttranslatiol 0.59 0.14 0.02 -0.43 0.175 carboxylmethyltransferase type II PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0970 b2742 nlpD activator of AmiC murein hydrolase CELLULAR Cell -0.03 0.24 -0.07 0.21 0.355 activity, lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_0971 b2741 rpoS RNA polymerase, sigma S (sigma 38) INFORMATION Transcription -0.09 -0.31 0.00 -0.21 0.390 factor STORAGE AND PROCESSING EcolC_0972 b2740 ygbN predicted transporter METABOLISM Carbohydrate 0.09 0.08 0.29 0.28 0.737 transport and metabolism EcolC_0973 b2739 ygbM conserved protein METABOLISM Carbohydrate 0.27 0.29 0.38 0.40 0.979 transport and metabolism EcolC_0974 b2738 ygbL predicted class II aldolase METABOLISM Carbohydrate 0.17 0.19 0.37 0.40 0.525 transport and metabolism EcolC_0975 b2737 ygbK conserved protein POORLY Function 0.29 0.21 0.17 0.09 0.220 CHARACTERIZ unknown ED EcolC_0976 b2736 ygbJ predicted dehydrogenase, with NAD(P)- METABOLISM Lipid 0.34 0.27 0.26 0.20 0.557 binding Rossmann-fold domain transport and metabolism EcolC_0977 b2735 ygbI predicted transcriptional regulator, DeoR INFORMATION Transcription 1.24 0.94 0.08 -0.21 0.170 family STORAGE AND PROCESSING EcolC_0979 b2733 mutS methyl-directed mismatch repair protein INFORMATION Replication, 0.51 0.25 0.11 -0.15 0.032 STORAGE AND recombination PROCESSING and repair EcolC_0980 b2732 ygbA predicted protein - - 0.18 0.58 0.39 0.79 0.098 EcolC_0981 b2731 fhlA DNA-binding transcriptional activator INFORMATION Transcription 0.29 0.61 0.32 0.64 0.851 STORAGE AND PROCESSING EcolC_0982 b2730 hypE carbamoyl dehydratase, hydrogenases 1,2,3 CELLULAR Posttranslatio -0.69 0.43 -0.02 1.09 0.000 maturation protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0983 b2729 hypD protein required for maturation of CELLULAR Posttranslatio -1.22 -0.04 -0.10 1.08 0.002 hydrogenases PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0984 b2728 hypC protein required for maturation of CELLULAR Posttranslatio -1.49 0.10 -0.06 1.52 0.002 hydrogenases 1 and 3 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0985 b2727 hypB GTP hydrolase involved in nickel liganding CELLULAR Posttranslatio -1.40 -0.24 -0.20 0.96 0.002 into hydrogenases PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_0986 b2726 hypA protein involved in nickel insertion into POORLY General -1.58 -0.10 -0.08 1.40 0.003 hydrogenases 3 CHARACTERIZ function ED prediction EcolC_0987 b2725 hycA regulator of the transcriptional regulator - -l -0.16 0.06 -0.03 0.19 0.079 FhlA EcolC_0988 b2724 hycB hydrogenase 3, Fe-S subunit METABOLISM Energy -0.08 -0.01 -0.09 -0.03 0.937 production and conversion EcolC_0989 b2723 hycC hydrogenase 3, membrane subunit METABOLISM Energy -0.07 0.02 0.03 0.12 0.462 production and conversion EcolC_0990 b2722 hycD hydrogenase 3, membrane subunit METABOLISM Energy -0.31 -0.26 -0.14 -0.09 0.543 production and conversion EcolC_0991 b2721 hycE hydrogenase 3, large subunit METABOLISM Energy -0.01 0.08 0.13 0.22 0.659 production and conversion EcolC_0992 b2720 hycF formate hydrogenlyase complex iron-sulfur METABOLISM Energy 0.22 0.07 0.45 0.29 0.396 protein production and conversion EcolC_0993 b2719 hycG hydrogenase 3 and formate hydrogenase METABOLISM Energy -0.29 -0.09 -0.06 0.15 0.559 complex, HycG subunit production and conversion EcolC_0994 b2718 hycH protein required for maturation of - - -0.13 0.18 0.35 0.66 0.143 hydrogenase 3 EcolC_0995 b2717 hycI protease involved in processing C-terminal METABOLISM Energy 0.61 0.57 0.25 0.21 0.961 end of HycE production and conversion EcolC_0996 b2716 ascB cryptic 6-phospho-beta-glucosidase METABOLISM Carbohydrate -0.02 -0.06 0.05 0.01 0.566 transport and metabolism EcolC_0997 b2715 ascF fused cellobiose/arbutin/salicin-specific METABOLISM Carbohydrate 0.21 0.18 0.06 0.03 0.295 PTS enzymes: IIB component/IC transport and component metabolism EcolC_0998 b2714 ascG DNA-binding transcriptional repressor INFORMATION Transcription 0.03 0.38 0.20 0.56 0.809 STORAGE AND PROCESSING EcolC_0999 b2713 hydN formate dehydrogenase-H, [4Fe-4S] METABOLISM Energy 0.01 0.14 0.22 0.36 0.233 ferredoxin subunit production and conversion EcolC_1000 b2712 hypF carbamoyl phosphate phosphatase and CELLULAR Posttranslatio 0.07 -0.04 0.01 -0.10 0.258 maturation protein for [NiFe] hydrogenases PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1001 b2711 norW NADH:flavorubredoxin oxidoreductase METABOLISM Energy 0.24 0.03 0.01 -0.20 0.292 production and conversion EcolC_1002 b2710 norV anaerobic nitric oxide reductase METABOLISM Energy 0.24 0.17 0.04 -0.03 0.292 flavorubredoxin production and conversion EcolC_1003 b2709 norR anaerobic nitric oxide reductase DNA- INFORMATION Transcription 0.48 -0.36 0.19 -0.65 0.051 binding transcriptional activator STORAGE AND PROCESSING EcolC_1004 b2708 gutQ D-arabinose 5-phosphate isomerase CELLULAR Cell 0.97 1.70 0.12 0.85 0.002 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1005 b2707 srlR DNA-bindng transcriptional repressor INFORMATION Transcription 0.91 1.64 0.14 0.88 0.004 STORAGE AND PROCESSING EcolC_1006 b2706 gutM DNA-binding transcriptional activator of INFORMATION Transcription 0.77 1.22 0.26 0.71 0.038 glucitol operon STORAGE AND PROCESSING EcolC_1007 b2705 srlD sorbitol-6-phosphate dehydrogenase METABOLISM Lipid 1.42 1.97 0.12 0.67 0.061 transport and metabolism EcolC_1008 b2704 srlB glucitol/sorbitol-specific enzyme IIA METABOLISM Carbohydrate 0.43 0.79 0.23 0.60 0.162 component of PTS transport and metabolism EcolC_1009 b2703 srlE glucitol/sorbitol-specific enzyme IIB METABOLISM Carbohydrate 1.30 1.82 0.11 0.63 0.053 component of PTS transport and metabolism EcolC_1010 b2702 srlA glucitol/sorbitol-specific enzyme IIC METABOLISM Carbohydrate 0.22 0.51 0.14 0.42 0.122 component of PTS transport and metabolism EcolC_1011 b2701 mltB membrane-bound lytic murein CELLULAR Cell 0.27 0.37 0.35 0.45 0.427 transglycosylase B PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1012 b2700 pncC NMN amidohydrolase POORLY General 0.36 0.45 0.28 0.37 0.394 CHARACTERIZ function ED prediction EcolC_1013 b2699 recA DNA strand exchange and recombination INFORMATION Replication,l -0.08 0.15 -0.20 0.04 0.416 protein with protease and nuclease activity STORAGE AND recombination PROCESSING and repair EcolC_1014 b2698 recX regulatory protein for RecA POORLY General 0.12 0.27 0.12 0.27 0.233 CHARACTERIZ function ED prediction EcolC_1015 b2697 alaS alanyl-tRNA synthetase INFORMATION Translation,l 0.06 -0.08 -0.32 -0.46 0.243 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1016 b2696 csrA pleiotropic regulatory protein for carbon CELLULAR Signal -1.43 -1.94 0.67 0.15 0.071 source metabolism PROCESSES transduction AND mechanisms SIGNALING EcolC_1017 b2690 yqaB fructose-1-P and 6-phosphogluconate POORLY General -0.19 -0.17 0.13 0.15 0.893 phosphatase CHARACTERIZ function ED prediction EcolC_1018 b2689 yqaA inner membrane protein, COG1238 family POORLY Functionl 0.26 -0.01 0.27 0.00 0.524 CHARACTERIZ unknown ED EcolC_1019 b2688 gshA glutamate-cysteine ligase METABOLISM Coenzyme -0.86 -0.48 -0.29 0.09 0.023 transport and metabolism EcolC_1020 b2687 luxS S-ribosylhomocysteine lyase CELLULAR Signal -0.28 0.06 -0.05 0.30 0.214 PROCESSES transduction AND mechanisms SIGNALING EcolC_1021 b2686 emrB multidrug efflux system protein METABOLISM Carbohydrate 0.03 0.21 0.31 0.49 0.587 transport and metabolism EcolC_1022 b2685 emrA multidrug efflux system CELLULAR Defense 0.07 0.30 -0.36 -0.13 0.272 PROCESSES mechanisms AND SIGNALING EcolC_1023 b2684 mprA DNA-binding transcriptional repressor of INFORMATION Transcription 0.09 0.55 -0.01 0.46 0.055 microcin B17 synthesis and multidrug STORAGE AND efflux PROCESSING EcolC_1024 b2683 ygaH probable L-valine exporter, norvaline - - 0.20 0.33 0.00 0.13 0.916 resistance EcolC_1025 b2682 ygaZ probable L-valine exporter, norvaline METABOLISM Amino acid 0.23 0.42 0.02 0.21 0.413 resistance transport and metabolism EcolC_1026 b2681 ygaY - - - 0.19 0.47 0.11 0.39 0.087 EcolC_1027 b2679 proX glycine betaine transporter subunit METABOLISM Amino acid -0.98 -1.68 0.04 -0.66 0.032 transport and metabolism EcolC_1028 b2678 proW glycine betaine transporter subunit METABOLISM Amino acid -0.28 -0.56 -0.17 -0.44 0.130 transport and metabolism EcolC_1029 b2677 proV glycine betaine transporter subunit METABOLISM Amino acid -0.47 -0.90 -0.27 -0.70 0.261 transport and metabolism EcolC_1030 b2676 nrdF ribonucleoside-diphosphate reductase 2, METABOLISM Nucleotide -0.06 -0.10 -0.13 -0.18 0.913 beta subunit, ferritin-like protein transport and metabolism EcolC_1031 b2675 nrdE ribonucleoside-diphosphate reductase 2, METABOLISM Nucleotide 0.04 -0.04 0.09 0.01 0.228 alpha subunit transport and metabolism EcolC_1032 b2674 nrdI flavodoxin required for NrdEF cluster METABOLISM Nucleotide -0.04 0.15 0.00 0.19 0.326 assembly transport and metabolism EcolC_1033 b2673 nrdH hydrogen donor for NrdEF electron CELLULAR Posttranslatio 0.12 0.00 0.13 0.01 0.930 transport system; glutaredoxin-like protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1034 b2672 ygaM ribosome-binding protein, probably - - -1.15 -1.50 0.30 -0.05 0.046 membrane-anchored, function unknown EcolC_1035 b2671 ygaC predicted protein - - 0.42 0.33 0.39 0.30 0.413 EcolC_1036 b2670 alaE alanine exporter, alanine-inducible, stress- - - -0.10 -0.02 0.19 0.27 0.641 responsive EcolC_1037 b2669 stpA DNA binding protein, nucleoid-associated POORLY General 0.09 0.04 0.01 -0.04 0.972 CHARACTERIZ function ED prediction EcolC_1038 b2668 ygaP predicted inner membrane protein with METABOLISM Inorganicl ion 1.46 1.06 0.00 -0.40 0.006 hydrolase activity transport and metabolism EcolC_1039 b2667 ygaV tributyltin-inducible repressor of ygaVP INFORMATION Transcription 1.09 0.92 0.29 0.13 0.553 STORAGE AND PROCESSING EcolC_1040 b2666 yqaE cyaR sRNA-regulated protein POORLY Function -0.58 -1.53 0.29 -0.65 0.005 CHARACTERIZ unknown ED EcolC_1041 b2665 ygaU predicted protein POORLY Function -0.11 -0.22 0.06 -0.05 0.168 CHARACTERIZ unknown ED EcolC_1042 b2664 csiR DNA-binding transcriptional repressor of INFORMATION Transcription -0.08 0.01 0.05 0.14 0.567 csiD STORAGE AND PROCESSING EcolC_1043 b2663 gabP gamma-aminobutyrate transporter METABOLISM Amino acid -0.01 -0.02 0.09 0.08 0.947 transport and metabolism EcolC_1044 b2662 gabT 4-aminobutyrate aminotransferase, PLP- METABOLISM Amino acid 0.10 0.24 -0.10 0.04 0.479 dependent transport and metabolism EcolC_1046 b2660 lhgO L-2-hydroxyglutarate oxidase POORLY General -0.28 -0.21 0.13 0.20 0.727 CHARACTERIZ function ED prediction EcolC_1047 b2659 csiD carbon starvation protein - -l -0.12 -0.31 -0.07 -0.26 0.410 EcolC_1048 b4462 ygaQ - - - -0.13 -0.13 -0.08 -0.08 0.743 EcolC_1051 b2648 pinH - - - 0.32 0.53 0.28 0.49 0.169 EcolC_1052 b2647 ypjA adhesin-like autotransporter CELLULAR Cell -0.29 -0.08 -0.06 0.16 0.680 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1065 b2619 ratA toxic UPF0083 family protein inhibitor of METABOLISM Lipid 0.31 0.48 0.08 0.26 0.089 70S ribosome formation transport and metabolism EcolC_1066 b2618 ratB conserved protein, UPF0125 family POORLY Function 0.37 -0.12 -0.16 -0.66 0.027 CHARACTERIZ unknown ED EcolC_1067 b2617 bamE lipoprotein component of BamABCDE OM INFORMATION Translation, -0.14 0.04 0.19 0.37 0.488 biogenesis complex STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1068 b2616 recN recombination and repair protein INFORMATION Replication, 0.19 -0.10 0.24 -0.06 0.111 STORAGE AND recombination PROCESSING and repair EcolC_1069 b2615 nadK NAD kinase METABOLISM Carbohydrate 0.00 0.23 0.21 0.44 0.273 transport and metabolism EcolC_1070 b2614 grpE heat shock protein CELLULAR Posttranslatio 0.77 0.74 -0.24 -0.26 0.903 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1071 b4461 yfjD inner membrane protein, UPF0053 family METABOLISM Inorganic ion 0.48 0.53 0.32 0.38 0.571 transport and metabolism EcolC_1072 b2611 ypjD predicted inner membrane protein POORLY General 0.19 0.33 0.27 0.41 0.733 CHARACTERIZ function ED prediction EcolC_1073 b2610 ffh Signal Recognition Particle (SRP) CELLULAR Intracellularl 0.17 0.25 -0.12 -0.04 0.406 component with 4.5S RNA (ffs) PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_1074 b2609 rpsP 30S ribosomal subunit protein S16 INFORMATION Translation, -2.37 -1.43 -0.11 0.84 0.018 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1075 b2608 rimM 16S rRNA processing protein INFORMATION Translation, -1.59 -0.90 -0.18 0.51 0.005 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1076 b2607 trmD tRNA m(1)G37 methyltransferase, SAM- INFORMATION Translation, -2.57 -1.77 -0.01 0.78 0.053 dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1077 b2606 rplS 50S ribosomal subunit protein L19 INFORMATION Translation, 0.11 0.35 -0.08 0.17 0.305 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1078 b2605 yfiB probable positive effector of YfiN activity, CELLULAR Cell 0.39 0.33 -0.04 -0.10 0.637 OM lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1079 b2604 yfiN predicted membrane-anchored diguanylate CELLULAR Signal 0.46 0.44 0.29 0.27 0.544 cyclase with an N-terminal periplasmic PROCESSES transduction domain AND mechanisms SIGNALING EcolC_1080 b2603 yfiR probable periplasmic inhibitor of YfiN - - 0.26 0.35 -0.08 0.01 0.433 activity EcolC_1081 b2602 yfiL lipoprotein - - -0.08 -0.37 0.53 0.23 0.053 EcolC_1082 b2601 aroF 3-deoxy-D-arabino-heptulosonate-7- METABOLISM Amino acid 0.25 -0.01 0.20 -0.06 0.042 phosphate synthase, tyrosine-repressible transport and metabolism EcolC_1083 b2600 tyrA fused chorismate mutase T/prephenate METABOLISM Amino acid 0.11 0.32 0.44 0.64 0.751 dehydrogenase transport and metabolism EcolC_1084 b2599 pheA fused chorismate mutase P/prephenate METABOLISM Amino acid -0.77 -0.78 -0.27 -0.28 0.741 dehydratase transport and metabolism EcolC_1085 b2597 raiA cold shock protein associated with 30S INFORMATION Translation, -1.65 -1.25 -0.13 0.27 0.301 ribosomal subunit STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1086 b2595 bamD lipoprotein required for OM biogenesis, in POORLY General -0.36 0.36 0.13 0.84 0.013 BamABCDE complex CHARACTERIZ function ED prediction l EcolC_1087 b2594 rluD 23S rRNA pseudouridine(1911,1915,1917) INFORMATION Translation, 0.52 0.78 0.35 0.61 0.469 synthase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1088 b2593 yfiH conserved protein, UPF0124 family POORLY Function 0.27 0.59 0.11 0.43 0.325 CHARACTERIZ unknown ED EcolC_1089 b2592 clpB protein disaggregation chaperone CELLULAR Posttranslatio 2.41 1.35 0.18 -0.89 0.002 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1090 b2587 kgtP alpha-ketoglutarate transporter METABOLISM Carbohydrate 0.46 0.17 0.15 -0.14 0.025 transport and metabolism EcolC_1091 b2586 yfiM required for high salt suppression of POORLY General 0.44 -0.86 0.24 -1.06 0.273 motility; probable lipoprotein CHARACTERIZ function ED prediction EcolC_1092 b2585 pssA phosphatidylserine synthase (CDP- METABOLISM Lipidl 0.06 0.23 0.00 0.17 0.075 diacylglycerol-serine O- transport and phosphatidyltransferase) metabolism EcolC_1093 b2584 pka protein lysine acetyltransferase METABOLISM Energy 1.40 0.89 0.03 -0.48 0.103 production and conversion EcolC_1094 b2583 yfiP conserved protein, DTW domain POORLY Function 0.16 0.35 0.00 0.20 0.211 CHARACTERIZ unknown ED EcolC_1095 b2582 trxC thioredoxin 2 CELLULAR Posttranslatio 0.44 0.48 0.36 0.39 0.971 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1096 b2581 yfiF predicted methyltransferase INFORMATIO Translation, -0.62 0.18 -0.15 0.65 0.036 N STORAGE ribosomal AND structure and PROCESSING biogenesis

EcolC_1097 b2580 ung -DNA-glycosylase INFORMATIO Replication, 0.06 0.35 -0.27 0.02 0.132 N STORAGE recombinatio AND n and repair PROCESSING EcolC_1098 b2579 grcA autonomous glycyl radical cofactor POORLY General 1.30 1.76 -0.47 -0.02 0.144 CHARACTERIZ function ED prediction EcolC_1099 b2578 eamB cysteine and O-acetylserine exporter METABOLISM Aminol acid 0.21 0.51 0.08 0.38 0.112 transport and metabolism EcolC_1100 b2577 yfiE predicted DNA-binding transcriptional INFORMATION Transcription 0.28 0.48 0.01 0.21 0.133 regulator STORAGE AND PROCESSING EcolC_1101 b2576 srmB ATP-dependent RNA helicase INFORMATION Replication, -0.18 0.18 0.16 0.52 0.216 STORAGE AND recombination PROCESSING and repair EcolC_1102 b2575 trmN tRNA1(Val) (adenine(37)-N6)- POORLY General 0.11 0.25 0.07 0.21 0.114 methyltransferase CHARACTERIZ function ED prediction l EcolC_1103 b2574 nadB quinolinate synthase, L-aspartate oxidase METABOLISM Coenzyme 0.22 0.31 0.40 0.50 0.528 (B protein) subunit transport and metabolism EcolC_1104 b2573 rpoE RNA polymerase, sigma 24 (sigma E) INFORMATION Transcription -0.14 -0.54 1.04 0.64 0.111 factor STORAGE AND PROCESSING EcolC_1105 b2572 rseA anti-sigma factor CELLULAR Signal 0.09 -0.78 1.15 0.29 0.019 PROCESSES transduction AND mechanisms SIGNALING EcolC_1106 b2571 rseB anti-sigma E factor, binds RseA CELLULAR Signal 0.44 0.29 0.61 0.45 0.826 PROCESSES transduction AND mechanisms SIGNALING EcolC_1107 b2570 rseC RseC protein involved in reduction of the CELLULAR Signal 0.71 0.38 0.40 0.06 0.079 SoxR iron-sulfur cluster PROCESSES transduction AND mechanisms SIGNALING EcolC_1108 b2569 lepA back-translocating elongation factor EF4, CELLULAR Cell 0.03 -0.30 -0.03 -0.36 0.540 GTPase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1109 b2568 lepB leader peptidase (signal peptidase I) CELLULAR Intracellular 0.40 0.56 0.21 0.37 0.496 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_1110 b2567 rnc RNase III INFORMATION Transcription -0.18 -0.31 0.30 0.17 0.508 STORAGE AND PROCESSING EcolC_1111 b2566 era membrane-associated, 16S rRNA-binding POORLY General 0.39 0.45 0.26 0.32 0.891 GTPase CHARACTERIZ function ED prediction EcolC_1112 b2565 recO gap repair protein INFORMATION Replication,l 0.20 -0.01 0.27 0.06 0.184 STORAGE AND recombination PROCESSING and repair EcolC_1113 b2564 pdxJ pyridoxine 5'-phosphate synthase METABOLISM Coenzyme -1.53 -1.35 -0.19 -0.01 0.033 transport and metabolism EcolC_1114 b2563 acpS holo-[acyl-carrier-protein] synthase 1 METABOLISM Lipid -0.88 -0.54 0.00 0.34 0.034 transport and metabolism EcolC_1115 b2562 yfhL predicted 4Fe-4S cluster-containing protein METABOLISM Energy 0.06 0.07 0.38 0.39 0.921 production and conversion EcolC_1116 b2561 yfhH predicted DNA-binding transcriptional INFORMATION Transcription -0.14 -0.01 0.10 0.23 0.546 regulator STORAGE AND PROCESSING EcolC_1117 b2560 pgpC conserved protein METABOLISM Amino acid 0.44 0.33 0.34 0.22 0.378 transport and metabolism EcolC_1119 b2558 mltF membrane-bound lytic transglycosylase F, CELLULAR Cell 0.03 -0.22 0.10 -0.14 0.251 murein hydrolase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1120 b2557 purL phosphoribosylformyl-glycineamide METABOLISM Nucleotide 0.04 0.05 0.16 0.16 0.921 synthetase transport and metabolism EcolC_1121 b2556 glrK sensor protein kinase regulating glmY CELLULAR Signal 0.21 -0.03 0.24 0.00 0.743 sRNA in two-component system with PROCESSES transduction response regulator GlrR AND mechanisms SIGNALING EcolC_1122 b2555 yfhG conserved protein - - 0.08 -0.15 0.11 -0.11 0.228 EcolC_1123 b2554 glrR response regulator regulating glmY sRNA CELLULAR Signal 0.06 0.19 0.01 0.14 0.389 in two-component system with sensor PROCESSES transduction protein GlrK AND mechanisms SIGNALING EcolC_1124 b2553 glnB regulatory protein P-II for glutamine METABOLISM Amino acid 0.04 0.22 0.00 0.18 0.234 synthetase transport and metabolism EcolC_1125 b2552 hmp fused nitric oxide METABOLISM Energy 0.82 0.21 0.47 -0.15 0.297 dioxygenase/dihydropteridine reductase 2 production and conversion EcolC_1126 b2551 glyA serine hydroxymethyltransferase METABOLISM Amino acid 0.75 0.87 -0.32 -0.20 0.389 transport and metabolism EcolC_1127 b2550 yphH predicted DNA-binding transcriptional INFORMATION Transcription -0.01 -0.12 0.00 -0.11 0.206 regulator STORAGE AND PROCESSING EcolC_1128 b2549 yphG conserved protein - - 0.19 0.24 0.19 0.25 0.499 EcolC_1129 b2548 yphF predicted sugar transporter subunit: METABOLISM Carbohydrate 0.20 0.25 0.21 0.25 0.937 periplasmic-binding component of ABC transport and superfamily metabolism EcolC_1130 b2547 yphE fused predicted sugar transporter subunits METABOLISM Carbohydrate 0.04 -0.01 -0.08 -0.14 0.962 of ABC superfamily: ATP-binding transport and components metabolism EcolC_1131 b2546 yphD predicted sugar transporter subunit: METABOLISM Carbohydrate 0.17 0.23 0.38 0.44 0.631 membrane component of ABC superfamily transport and metabolism EcolC_1132 b2545 yphC predicted oxidoreductase, Zn-dependent METABOLISM Amino acid 0.00 -0.11 -0.02 -0.13 0.873 and NAD(P)-binding transport and metabolism EcolC_1133 b2544 yphB conserved protein METABOLISM Carbohydrate -0.02 0.19 0.24 0.46 0.398 transport and metabolism EcolC_1135 b2542 hcaD phenylpropionate dioxygenase, ferredoxin POORLY General 0.04 0.18 0.24 0.37 0.119 reductase subunit CHARACTERIZ function ED prediction EcolC_1136 b2541 hcaB 2,3-dihydroxy-2,3- METABOLISM Lipidl 0.03 -0.04 -0.03 -0.09 0.923 dihydrophenylpropionate dehydrogenase transport and metabolism EcolC_1137 b2540 hcaC 3-phenylpropionate dioxygenase, predicted METABOLISM Inorganic ion 0.28 0.53 0.29 0.54 0.250 ferredoxin subunit transport and metabolism EcolC_1138 b2539 hcaF 3-phenylpropionate dioxygenase, small METABOLISM Secondary -0.02 -0.11 -0.05 -0.14 0.893 (beta) subunit metabolites biosynthesis, transport and catabolism EcolC_1139 b2538 hcaE 3-phenylpropionate dioxygenase, large METABOLISM Inorganic ion 0.02 0.10 0.04 0.12 0.294 (alpha) subunit transport and metabolism EcolC_1140 b2537 hcaR DNA-binding transcriptional activator of 3- INFORMATION Transcription 1.62 0.54 0.36 -0.72 0.003 phenylpropionic acid catabolism STORAGE AND PROCESSING EcolC_1141 b2536 hcaT predicted 3-phenylpropionic transporter METABOLISM Carbohydrate 0.08 0.17 0.39 0.47 0.376 transport and metabolism EcolC_1142 b2535 csiE stationary phase inducible protein INFORMATION Transcription 0.68 -0.26 0.36 -0.58 0.002 STORAGE AND PROCESSING EcolC_1143 b2534 yfhR S9 peptidase family protein, function POORLY General -0.20 -0.11 -0.10 -0.01 0.751 unknown CHARACTERIZ function ED prediction EcolC_1144 b2533 suhB inositol monophosphatase METABOLISM Carbohydratel 0.06 -0.01 0.33 0.25 0.734 transport and metabolism EcolC_1146 b2531 iscR DNA-binding transcriptional repressor INFORMATION Transcription -0.27 -0.31 0.01 -0.03 0.460 STORAGE AND PROCESSING EcolC_1147 b2530 iscS cysteine desulfurase (tRNA METABOLISM Amino acid 0.58 0.36 -0.02 -0.23 0.533 sulfurtransferase), PLP-dependent transport and metabolism EcolC_1148 b2529 iscU iron-sulfur cluster assembly scaffold METABOLISM Energy 0.29 0.10 0.02 -0.17 0.659 protein production and conversion EcolC_1149 b2528 iscA FeS cluster assembly protein POORLY Function 0.38 0.36 0.02 -0.01 0.457 CHARACTERIZ unknown ED EcolC_1150 b2527 hscB DnaJ-like molecular chaperone specific for CELLULAR Posttranslatio 0.51 0.46 0.22 0.17 0.856 IscU PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1151 b2526 hscA DnaK-like molecular chaperone specific CELLULAR Posttranslatio 0.46 0.19 -0.10 -0.37 0.027 for IscU PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1152 b2525 fdx [2Fe-2S] ferredoxin METABOLISM Energy 0.37 0.08 -0.02 -0.31 0.038 production and conversion EcolC_1153 b2524 iscX Iron binding protein associated with IscS; POORLY Function 0.76 0.24 0.08 -0.45 0.108 putative molecular adaptor of IscS function CHARACTERIZ unknown ED EcolC_1154 b2523 pepB aminopeptidase B METABOLISM Amino acid 0.30 0.12 0.05 -0.12 0.416 transport and metabolism EcolC_1155 b2522 sseB rhodanase-like enzyme, sulfur transfer - - 0.23 0.32 0.35 0.44 0.743 from thiosulfate EcolC_1156 b2521 sseA 3-mercaptopyruvate sulfurtransferase METABOLISM Inorganic ion 0.33 0.51 -0.23 -0.05 0.091 transport and metabolism EcolC_1157 b2520 yfhM conserved protein POORLY General 0.29 0.25 0.03 -0.01 0.979 CHARACTERIZ function ED prediction EcolC_1158 b2519 pbpC penicillin-binding protein PBP1C murein CELLULAR Celll -0.01 -0.06 0.01 -0.04 0.843 transglycosylase; inactive transpeptidase PROCESSES wall/membran domain AND e/envelope SIGNALING biogenesis EcolC_1159 b2518 ndk multifunctional nucleoside diphosphate METABOLISM Nucleotide 0.19 -0.01 0.25 0.05 0.168 kinase and apyrimidinic endonuclease and transport and 3'-phosphodiesterase metabolism EcolC_1160 b2517 rlmN dual specificity 23S rRNA m(2)A2503, POORLY General 0.30 0.36 0.34 0.41 0.899 tRNA m(2)A37 methyltransferase, SAM- CHARACTERIZ function dependent ED prediction EcolC_1161 b2516 rodZ cytoskeletal protein required for MreB POORLY Functionl 0.17 -0.30 0.25 -0.22 0.026 assembly CHARACTERIZ unknown ED EcolC_1162 b2515 ispG 1-hydroxy-2-methyl-2-(E)-butenyl 4- METABOLISM Lipid 0.43 0.12 0.12 -0.19 0.234 diphosphate synthase transport and metabolism EcolC_1163 b2514 hisS histidyl tRNA synthetase INFORMATION Translation, 0.12 0.04 0.04 -0.04 0.858 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1164 b2513 yfgM putative anti-RcsB factor POORLY Function -0.24 -0.34 -0.09 -0.18 0.135 CHARACTERIZ unknown ED EcolC_1165 b2512 bamB lipoprotein required for OM biogenesis, in POORLY Function 0.14 0.20 0.00 0.06 0.783 BamABCDE complex CHARACTERIZ unknown ED EcolC_1166 b2511 der GTPase; multicopy suppressor of ftsJ POORLY General -0.02 0.03 0.15 0.20 0.826 CHARACTERIZ function ED prediction EcolC_1167 b2510 yfgJ conserved protein, DUF1407 family - -l 0.34 0.48 0.12 0.27 0.694 EcolC_1169 b2508 guaB IMP dehydrogenase METABOLISM Nucleotide 0.24 0.33 -0.05 0.04 0.768 transport and metabolism EcolC_1171 b2506 yfgI conserved protein - - -0.09 -0.02 0.09 0.17 0.907 EcolC_1172 b2505 yfgH outer membrane integrity lipoprotein CELLULAR Cell -0.25 -0.15 -0.08 0.03 0.715 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1173 b2503 yfgF cyclic-di-GMP phosphodiesterase, CELLULAR Signal -0.06 0.04 0.06 0.16 0.413 anaerobic PROCESSES transduction AND mechanisms SIGNALING EcolC_1174 b2502 ppx exopolyphosphatase METABOLISM Nucleotide 0.01 0.26 -0.03 0.22 0.099 transport and metabolism EcolC_1175 b2501 ppk polyphosphate kinase, component of RNA METABOLISM Inorganic ion -0.42 0.00 -0.07 0.34 0.017 transport and metabolism EcolC_1176 b2500 purN phosphoribosylglycinamide METABOLISM Nucleotide 0.18 0.32 0.15 0.30 0.824 formyltransferase 1 transport and metabolism EcolC_1177 b2499 purM phosphoribosylaminoimidazole synthetase METABOLISM Nucleotide -0.01 0.18 0.37 0.56 0.279 transport and metabolism EcolC_1178 b2498 upp uracil phosphoribosyltransferase METABOLISM Nucleotide -1.19 -0.47 -0.24 0.49 0.033 transport and metabolism EcolC_1179 b2497 uraA uracil permease METABOLISM Nucleotide 0.02 -0.23 -0.04 -0.30 0.209 transport and metabolism EcolC_1180 b2496 hda ATPase regulatory factor involved in DnaA INFORMATION Replication, 0.38 0.51 0.20 0.32 0.816 inactivation STORAGE AND recombination PROCESSING and repair EcolC_1181 b2495 yfgD predicted oxidoreductase METABOLISM Inorganic ion 0.71 0.30 0.24 -0.17 0.244 transport and metabolism EcolC_1182 b2494 yfgC periplasmic predicted metalloprotease, POORLY General 0.37 0.12 0.13 -0.12 0.750 required for LoiP localization; TPR repeats CHARACTERIZ function ED prediction EcolC_1183 b2493 yfgO predicted inner membrane permease, POORLY Generall 0.45 0.14 0.34 0.03 0.576 UPF0118 family CHARACTERIZ function ED prediction EcolC_1184 b2492 focB predicted formate transporter METABOLISM Inorganicl ion 0.18 -0.04 0.06 -0.16 0.368 transport and metabolism EcolC_1185 b2491 hyfR DNA-binding transcriptional activator, INFORMATION Transcription 0.14 0.22 0.41 0.50 0.359 formate sensing STORAGE AND PROCESSING EcolC_1186 b2490 hyfJ predicted processing element hydrogenase - - 0.03 0.00 0.09 0.05 0.640 4 EcolC_1187 b2489 hyfI hydrogenase 4, Fe-S subunit METABOLISM Energy 0.32 0.29 0.33 0.30 0.975 production and conversion EcolC_1188 b2488 hyfH hydrogenase 4, Fe-S subunit METABOLISM Energy 0.09 0.00 0.17 0.09 0.853 production and conversion EcolC_1189 b2487 hyfG hydrogenase 4, subunit METABOLISM Energy 0.06 0.02 0.12 0.08 0.985 production and conversion EcolC_1190 b2486 hyfF hydrogenase 4, membrane subunit METABOLISM Energy -0.24 -0.28 -0.20 -0.24 0.721 production and conversion EcolC_1191 b2485 hyfE hydrogenase 4, membrane subunit METABOLISM Energy -0.03 0.27 0.22 0.52 0.394 production and conversion EcolC_1192 b2484 hyfD hydrogenase 4, membrane subunit METABOLISM Energy -0.13 -0.01 0.02 0.14 0.497 production and conversion EcolC_1194 b2482 hyfB hydrogenase 4, membrane subunit METABOLISM Energy -0.73 -0.59 -0.52 -0.39 0.905 production and conversion EcolC_1195 b2481 hyfA hydrogenase 4, 4Fe-4S subunit METABOLISM Energy -0.06 -0.04 -0.07 -0.05 0.832 production and conversion EcolC_1196 b2480 bcp peroxiredoxin; thiol peroxidase, CELLULAR Posttranslatio -0.45 -0.34 -0.02 0.09 0.589 thioredoxin-dependent PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1197 b2479 gcvR DNA-binding transcriptional repressor, METABOLISM Amino acid -0.17 -0.27 0.04 -0.07 0.620 regulatory protein accessory to GcvA transport and metabolism EcolC_1198 b2478 dapA dihydrodipicolinate synthase METABOLISM Amino acid -1.09 -0.26 -0.05 0.78 0.009 transport and metabolism EcolC_1199 b2477 bamC lipoprotein required for OM biogenesis, in CELLULAR Cell -0.16 -0.19 -0.01 -0.05 0.921 BamABCDE complex PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1200 b2476 purC phosphoribosylaminoimidazole- METABOLISM Nucleotide 0.06 0.02 0.19 0.15 0.955 succinocarboxamide synthetase transport and metabolism EcolC_1201 b2475 ypfJ conserved protein POORLY General -0.16 -0.46 0.21 -0.09 0.057 CHARACTERIZ function ED prediction l EcolC_1203 b2473 ypfH predicted hydrolase POORLY General 0.15 0.14 0.26 0.25 0.910 CHARACTERIZ function ED prediction EcolC_1204 b4547 ypfN predicted membrane protein, UPF0370 - -l 0.37 0.13 0.36 0.12 0.274 family EcolC_1205 b2472 dapE N-succinyl-diaminopimelate deacylase METABOLISM Amino acid 0.62 0.10 0.11 -0.41 0.027 transport and metabolism EcolC_1206 b2471 yffB predicted reductase, function unknown, METABOLISM Inorganic ion 0.48 0.03 0.04 -0.41 0.036 ArsC family; low abundance protein transport and metabolism EcolC_1207 b2470 acrD aminoglycoside/multidrug efflux system CELLULAR Defense 0.14 -0.05 -0.10 -0.29 0.804 PROCESSES mechanisms AND SIGNALING EcolC_1208 b2469 narQ sensory histidine kinase in two-component CELLULAR Signal 0.54 0.31 0.34 0.11 0.364 regulatory system with NarP (NarL) PROCESSES transduction AND mechanisms SIGNALING EcolC_1209 b2468 aegA fused predicted oxidoreductase: FeS METABOLISM Amino acid -0.34 -0.11 0.04 0.27 0.255 binding subunit/NAD/FAD-binding subunit transport and metabolism EcolC_1210 b2467 nudK GDP-mannose pyrophosphatase INFORMATION Replication, 0.11 0.45 -0.11 0.23 0.808 STORAGE AND recombination PROCESSING and repair EcolC_1211 b2466 ypfG predicted protein - - 0.45 0.33 0.04 -0.07 0.880 EcolC_1212 b2465 tktB transketolase 2, thiamin-binding METABOLISM Carbohydrate -0.76 -1.32 0.25 -0.30 0.010 transport and metabolism EcolC_1213 b2464 talA transaldolase A METABOLISM Carbohydrate -0.91 -1.27 -0.09 -0.45 0.116 transport and metabolism EcolC_1214 b2463 maeB fused malic enzyme predicted METABOLISM Energy 1.19 0.14 -0.44 -1.48 0.076 oxidoreductase/predicted production phosphotransacetylase and conversion EcolC_1216 b2461 eutP conserved protein with nucleoside METABOLISM Amino acid 0.23 0.13 0.13 0.03 0.264 triphosphate hydrolase domain transport and metabolism EcolC_1217 b2460 eutQ conserved protein METABOLISM Amino acid 0.39 0.47 0.23 0.31 0.990 transport and metabolism EcolC_1218 b2459 eutT cobalamin adenosyltransferase involved in METABOLISM Amino acid 0.17 0.23 0.22 0.27 0.902 ethanolamine utilization transport and metabolism EcolC_1219 b2458 eutD phosphate acetyltransferase METABOLISM Energy 0.01 -0.09 -0.02 -0.12 0.516 production and conversion EcolC_1221 b2456 eutN Ethanolamine catabolic microcompartment METABOLISM Secondary 0.20 0.52 0.21 0.52 0.781 shell protein metabolites biosynthesis, transport and catabolism EcolC_1222 b2455 eutE aldehyde oxidoreductase, ethanolamine METABOLISM Energy 0.06 -0.05 -0.01 -0.12 0.499 utilization protein production and conversion EcolC_1223 b2454 eutJ predicted chaperonin, ethanolamine METABOLISM Amino acid -0.08 -0.21 -0.17 -0.30 0.103 utilization protein transport and metabolism EcolC_1224 b2453 eutG ethanol dehydrogenase involved in METABOLISM Energy 0.06 0.10 0.04 0.07 0.842 ethanolamine utilization; aldehyde production reductase, converts acetaldehyde to ethanol and conversion EcolC_1225 b2452 eutH ethanolamine transporter METABOLISM Amino acid 0.18 0.06 0.29 0.16 0.473 transport and metabolism EcolC_1228 b2450 yffS CPZ-55 prophage; predicted protein - - 0.17 0.00 0.05 -0.12 0.118 EcolC_1238 b2441 eutB ethanolamine ammonia-lyase, large METABOLISM Amino acid 0.20 0.14 0.22 0.16 0.367 subunit, heavy chain transport and metabolism EcolC_1239 b2440 eutC ethanolamine ammonia-lyase, small METABOLISM Amino acid 0.34 0.09 0.13 -0.11 0.521 subunit (light chain) transport and metabolism EcolC_1241 b2438 eutK predicted carboxysome structural protein METABOLISM Secondary 0.10 -0.01 0.19 0.08 0.271 with predicted role in ethanolamine metabolites utilization biosynthesis, transport and catabolism EcolC_1242 b2437 eutR eut operon transcriptional activator, AraC INFORMATION Transcription 0.22 0.01 0.21 0.00 0.126 family STORAGE AND PROCESSING EcolC_1243 b2436 hemF coproporphyrinogen III oxidase METABOLISM Coenzyme 0.97 1.13 0.20 0.35 0.229 transport and metabolism EcolC_1244 b2435 amiA N-acetylmuramoyl-l-alanine amidase I CELLULAR Cell 0.66 0.61 0.18 0.14 0.754 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1246 b2433 yfeZ inner membrane protein - - 0.27 0.34 0.24 0.31 0.588 EcolC_1247 b2432 yfeY RpoE-regulated lipoprotein - - 0.18 0.22 0.39 0.43 0.650 EcolC_1249 b2430 yfeW penicillin binding protein PBP4B; weak CELLULAR Defense 0.51 0.66 0.42 0.57 0.516 DD-carboxypeptidase activity PROCESSES mechanisms AND SIGNALING EcolC_1250 b2429 murP N-acetylmuramic acid permease, EIIBC METABOLISM Carbohydrate 1.20 0.27 -0.01 -0.94 0.041 component, PTS system transport and metabolism EcolC_1251 b2428 murQ N-acetylmuramic acid 6-phosphate POORLY General 0.85 0.44 0.12 -0.28 0.076 (MurNAc-6-P) etherase CHARACTERIZ function ED prediction EcolC_1252 b2427 murR repressor for murPQ, MurNAc 6-P INFORMATION Transcriptionl 0.04 0.15 -0.09 0.02 0.467 inducible STORAGE AND PROCESSING EcolC_1253 b2426 ucpA furfural resistance protein, predicted short- METABOLISM Lipid 1.72 0.88 -0.20 -1.04 0.022 chain oxidoreductase transport and metabolism EcolC_1254 b2425 cysP thiosulfate-binding protein METABOLISM Inorganic ion 0.13 0.19 0.27 0.33 0.834 transport and metabolism EcolC_1256 b2423 cysW sulfate/thiosulfate ABC transporter subunit METABOLISM Inorganic ion -0.02 0.22 -0.02 0.23 0.121 transport and metabolism EcolC_1257 b2422 cysA sulfate/thiosulfate transporter subunit METABOLISM Inorganic ion 0.16 0.33 0.09 0.27 0.972 transport and metabolism EcolC_1258 b2421 cysM cysteine synthase B (O-acetylserine METABOLISM Amino acid 0.13 0.41 -0.07 0.21 0.230 sulfhydrolase B) transport and metabolism EcolC_1259 b2419 yfeK predicted protein INFORMATION Translation, 0.15 0.11 0.32 0.28 0.858 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1260 b2418 pdxK pyridoxal-pyridoxamine METABOLISM Coenzyme -0.23 0.06 -0.20 0.09 0.834 kinase/hydroxymethylpyrimidine kinase transport and metabolism EcolC_1261 b2417 crr glucose-specific enzyme IIA component of METABOLISM Carbohydrate -0.71 -0.63 -0.04 0.04 0.949 PTS transport and metabolism EcolC_1262 b2416 ptsI PEP-protein phosphotransferase of PTS METABOLISM Carbohydrate 0.25 0.45 0.09 0.29 0.202 system (enzyme I) transport and metabolism EcolC_1263 b2415 ptsH phosphohistidinoprotein-hexose METABOLISM Carbohydrate 0.87 1.74 0.00 0.88 0.062 phosphotransferase component of PTS transport and system (Hpr) metabolism EcolC_1264 b2414 cysK cysteine synthase A, O-acetylserine METABOLISM Amino acid -0.56 -0.32 -0.21 0.03 0.315 sulfhydrolase A subunit transport and metabolism EcolC_1265 b2413 cysZ predicted inner membrane protein METABOLISM Amino acid 0.03 0.09 0.02 0.08 0.930 transport and metabolism EcolC_1266 b2412 zipA FtsZ stabilizer CELLULAR Cell cycle -0.21 -0.25 0.12 0.09 0.732 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_1267 b2411 ligA DNA ligase, NAD(+)-dependent INFORMATION Replication, 0.46 0.54 0.17 0.24 0.932 STORAGE AND recombination PROCESSING and repair EcolC_1268 b4546 ypeB predicted protein POORLY Function 0.26 0.13 0.25 0.13 0.625 CHARACTERIZ unknown ED EcolC_1269 b2410 yfeH predicted inner membrane protein POORLY General 0.24 0.18 0.10 0.04 0.467 CHARACTERIZ function ED prediction l EcolC_1270 b2409 yfeR predicted DNA-binding transcriptional INFORMATION Transcription 0.62 0.48 0.13 0.00 0.768 regulator STORAGE AND PROCESSING EcolC_1271 - - hypothetical protein - - -0.10 -0.05 -0.08 -0.03 0.583 EcolC_1272 b2400 gltX glutamyl-tRNA synthetase INFORMATION Translation, 0.25 0.53 0.16 0.44 0.100 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1273 b2399 yfeD conserved protein, DUF1323 family; N- - - 0.48 0.31 0.18 0.00 0.282 terminal HTH domain of the MerR superfamily EcolC_1274 b2398 yfeC predicted DNA-binding protein, DUF1323 - - 0.22 0.12 0.13 0.03 0.589 family EcolC_1275 b2395 yfeA predicted diguanylate cyclase CELLULAR Signal -0.87 -0.91 -0.54 -0.58 0.652 PROCESSES transduction AND mechanisms SIGNALING EcolC_1277 b2393 nupC nucleoside (except guanosine) transporter METABOLISM Nucleotide 0.07 0.28 -0.03 0.17 0.874 transport and metabolism EcolC_1278 b2392 mntH manganese/divalent cation transporter METABOLISM Inorganic ion 0.41 -0.04 0.63 0.17 0.168 transport and metabolism EcolC_1279 b2390 ypeC conserved protein - - 0.77 0.03 0.60 -0.14 0.017 EcolC_1280 b2389 yfeO predicted ion channel protein METABOLISM Inorganic ion 0.18 -0.21 0.46 0.07 0.075 transport and metabolism EcolC_1281 b2388 glk METABOLISM Carbohydrate 0.06 0.49 -0.05 0.38 0.031 transport and metabolism EcolC_1282 b2387 fryB predicted enzyme IIB component of PTS METABOLISM Carbohydrate 0.06 0.06 0.07 0.07 0.894 transport and metabolism EcolC_1283 b2386 fryC predicted enzyme IIC component of PTS METABOLISM Carbohydrate -0.01 0.13 0.13 0.26 0.421 transport and metabolism EcolC_1284 b2385 ypdF Xaa-Pro aminopeptidase METABOLISM Amino acid -0.06 -0.08 -0.10 -0.12 0.902 transport and metabolism EcolC_1285 b2384 ypdE aminopeptidase METABOLISM Carbohydrate -0.18 -0.18 0.00 0.00 0.947 transport and metabolism EcolC_1286 b2383 fryA fused predicted PTS enzymes: Hpr METABOLISM Carbohydrate -0.16 -0.06 -0.01 0.09 0.929 component/enzyme I component/enzyme transport and IIA component metabolism EcolC_1287 b2382 ypdC predicted DNA-binding protein INFORMATION Transcription 0.34 0.73 0.27 0.66 0.517 STORAGE AND PROCESSING EcolC_1288 b2381 ypdB response regulator activating yhjX; INFORMATION Transcription 0.61 0.57 0.20 0.16 0.860 pyruvate-responsive YpdAB two- STORAGE AND component system PROCESSING EcolC_1289 b2380 ypdA sensor kinase regulating yhjX; pyruvate- CELLULAR Signal 0.05 0.37 -0.12 0.20 0.460 responsive YpdAB two-component system PROCESSES transduction AND mechanisms SIGNALING EcolC_1290 b2379 alaC valine-pyruvate aminotransferase 3 METABOLISM Amino acid -0.37 -0.12 -0.17 0.08 0.358 transport and metabolism EcolC_1291 b2378 lpxP palmitoleoyl-acyl carrier protein (ACP)- CELLULAR Cell 0.36 0.58 0.40 0.62 0.071 dependent acyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1292 b2377 yfdY predicted inner membrane protein - - 0.06 -0.12 0.63 0.46 0.417 EcolC_1293 b2376 ypdI predicted lipoprotein involved in colanic - - 0.06 0.13 0.48 0.55 0.808 acid biosynthesis EcolC_1294 b2375 yfdX predicted protein - - 0.15 0.10 0.01 -0.03 0.829 EcolC_1295 b2374 frc formyl-CoA transferase, NAD(P)-binding METABOLISM Energy -0.05 -0.09 -0.18 -0.22 0.434 production and conversion EcolC_1296 b2373 oxc oxalyl CoA decarboxylase, ThDP- METABOLISM Amino acid 0.02 0.00 -0.17 -0.20 0.821 dependent transport and metabolism EcolC_1297 b2372 yfdV predicted transporter POORLY General -0.19 -0.28 -0.14 -0.23 0.535 CHARACTERIZ function ED prediction EcolC_1298 b2371 yfdE predicted CoA-transferase, NAD(P)- METABOLISM Energyl 0.22 0.22 -0.01 -0.01 0.640 binding production and conversion EcolC_1299 b2370 evgS hybrid sensory histidine kinase in two- CELLULAR Signal 0.95 0.10 0.43 -0.42 0.025 component regulatory system with EvgA PROCESSES transduction AND mechanisms SIGNALING EcolC_1300 b2369 evgA DNA-binding response regulator in two- CELLULAR Signal 0.29 0.38 0.07 0.17 0.874 component regulatory system with EvgS PROCESSES transduction AND mechanisms SIGNALING EcolC_1301 b2368 emrK EmrKY-TolC multidrug resistance efflux CELLULAR Defense -0.18 -0.16 -0.15 -0.13 0.839 pump, membrane fusion protein component PROCESSES mechanisms AND SIGNALING EcolC_1302 b2367 emrY predicted multidrug efflux system METABOLISM Carbohydrate -0.08 -0.16 -0.14 -0.22 0.363 transport and metabolism EcolC_1303 b2366 dsdA D-serine dehydratase METABOLISM Amino acid 0.11 -0.09 0.03 -0.17 0.671 transport and metabolism EcolC_1304 b2365 dsdX D-serine permease METABOLISM Carbohydrate 0.02 0.18 0.21 0.38 0.355 transport and metabolism EcolC_1305 b2364 dsdC DNA-binding transcriptional dual regulator INFORMATION Transcription -0.17 -0.15 -0.18 -0.15 0.830 STORAGE AND PROCESSING EcolC_1306 b2347 yfdC predicted inner membrane protein METABOLISM Inorganic ion -0.04 -0.15 0.37 0.27 0.303 transport and metabolism EcolC_1307 b2346 mlaA ABC transporter maintaining OM lipid CELLULAR Cell 0.17 0.02 -0.02 -0.17 0.297 asymmetry, OM lipoprotein component PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1308 b2345 yfdF predicted protein - - -0.11 -0.05 -0.05 0.01 0.462 EcolC_1309 b2344 fadL long-chain fatty acid outer membrane METABOLISM Lipid -1.29 -1.81 -1.51 -2.03 0.089 transporter transport and metabolism EcolC_1310 b2343 yfcZ conserved protein, UPF0381 family POORLY Function -0.20 0.81 0.01 1.02 0.001 CHARACTERIZ unknown ED EcolC_1311 b2342 fadI beta-ketoacyl-CoA thiolase, anaerobic, METABOLISM Lipid 0.40 0.24 -0.22 -0.38 0.604 subunit transport and metabolism EcolC_1312 b2341 fadJ fused enoyl-CoA hydratase and epimerase METABOLISM Lipid 0.49 -0.07 0.17 -0.40 0.038 and isomerase/3-hydroxyacyl-CoA transport and dehydrogenase metabolism EcolC_1313 b2340 sixA phosphohistidine phosphatase CELLULAR Signal 0.25 0.28 0.59 0.62 0.427 PROCESSES transduction AND mechanisms SIGNALING EcolC_1321 b2331 smrB predicted DNA endonuclease POORLY Function 0.59 0.64 0.36 0.41 0.808 CHARACTERIZ unknown ED EcolC_1324 b2328 mepA murein DD-endopeptidase CELLULAR Cell 0.33 0.37 0.22 0.26 0.986 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1325 b2327 yfcA inner membrane protein, UPF0721 family POORLY General 0.20 0.05 -0.03 -0.18 0.011 CHARACTERIZ function ED prediction EcolC_1326 b2326 epmC Elongation Factor P Lys34 hydroxylase POORLY Functionl 0.22 0.17 0.09 0.04 0.808 CHARACTERIZ unknown ED EcolC_1327 b2325 yfcL predicted protein - - 0.38 0.26 0.21 0.10 0.499 EcolC_1328 b2324 mnmC fused 5-methylaminomethyl-2-thiouridine- POORLY Function 0.87 0.45 0.39 -0.03 0.047 forming enzyme methyltransferase and CHARACTERIZ unknown FAD-dependent demodification enzyme ED EcolC_1329 b2323 fabB 3-oxoacyl-[acyl-carrier-protein] synthase I METABOLISM Lipid -0.16 -1.03 0.73 -0.14 0.002 transport and metabolism EcolC_1330 b2322 yfcJ putative arabinose efflux transporter METABOLISM Carbohydrate 0.17 0.24 0.13 0.19 0.821 transport and metabolism EcolC_1331 b2321 flk predicted flagella assembly protein - - 0.35 -0.04 0.01 -0.38 0.080 EcolC_1332 b2320 pdxB erythronate-4-phosphate dehydrogenase METABOLISM Coenzyme 0.04 -0.17 -0.07 -0.29 0.664 transport and metabolism EcolC_1333 b2319 usg predicted semialdehyde dehydrogenase METABOLISM Amino acid 0.29 0.45 0.07 0.24 0.614 transport and metabolism EcolC_1334 b2318 truA tRNA pseudouridine(38-40) synthase INFORMATION Translation, 0.23 0.11 0.28 0.16 0.089 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1335 b2317 dedA conserved inner membrane protein POORLY Function 0.14 0.18 0.35 0.39 0.995 CHARACTERIZ unknown ED EcolC_1336 b2316 accD acetyl-CoA carboxylase, beta METABOLISM Lipid -0.03 0.15 0.00 0.18 0.557 (carboxyltransferase) subunit transport and metabolism EcolC_1337 b2315 folC bifunctional folylpolyglutamate synthase/ METABOLISM Coenzyme 0.27 0.32 0.12 0.16 0.902 dihydrofolate synthase transport and metabolism EcolC_1338 b2314 dedD membrane-anchored periplasmic protein POORLY Function 0.17 0.14 0.25 0.22 0.697 involved in septation CHARACTERIZ unknown ED EcolC_1339 b2313 cvpA membrane protein required for colicin V POORLY General -0.52 -0.13 0.01 0.40 0.055 production CHARACTERIZ function ED prediction EcolC_1340 b2312 purF amidophosphoribosyltransferase METABOLISM Nucleotidel -0.08 0.08 0.07 0.23 0.455 transport and metabolism EcolC_1341 b2311 ubiX 3-octaprenyl-4-hydroxybenzoate carboxy- METABOLISM Coenzyme 0.15 0.00 0.11 -0.03 0.362 lyase transport and metabolism EcolC_1342 b2310 argT lysine/arginine/ornithine transporter METABOLISM Amino acid 0.71 0.44 0.15 -0.11 0.004 subunit transport and metabolism EcolC_1343 b2309 hisJ histidine/lysine/arginine/ornithine METABOLISM Amino acid 0.72 -0.22 -0.04 -0.98 0.002 transporter subunit transport and metabolism EcolC_1344 b2308 hisQ histidine/lysine/arginine/ornithine METABOLISM Amino acid 0.29 -0.55 -0.11 -0.95 0.003 transporter permease subunit transport and metabolism EcolC_1345 b2307 hisM histidine/lysine/arginine/ornithine METABOLISM Amino acid 0.45 -0.23 0.20 -0.48 0.056 transporter subunit transport and metabolism EcolC_1346 b2306 hisP histidine/lysine/arginine/ornithine METABOLISM Amino acid 0.84 -0.03 0.16 -0.71 0.088 transporter subunit transport and metabolism EcolC_1347 b2305 yfcI conserved protein POORLY Function 0.60 0.37 0.47 0.24 0.125 CHARACTERIZ unknown ED EcolC_1348 b2304 yfcH conserved protein with NAD(P)-binding POORLY General 0.12 0.47 -0.04 0.31 0.047 Rossmann-fold domain CHARACTERIZ function ED prediction EcolC_1349 b2303 folX D-erythro-7,8-dihydroneopterin METABOLISM Coenzymel 0.54 0.31 0.19 -0.03 0.202 triphosphate 2'-epimerase and transport and dihydroneopterin aldolase metabolism EcolC_1350 b2302 yfcG GSH-dependent disulfide bond CELLULAR Posttranslatio 0.16 -0.19 0.30 -0.05 0.353 oxidoreductase PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1351 b2301 yfcF glutathione S-transferase CELLULAR Posttranslatio -0.03 -0.14 0.15 0.04 0.432 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1352 b2300 yfcE phosphodiesterase activity on bis-pNPP POORLY General 0.43 0.32 0.14 0.04 0.333 CHARACTERIZ function ED prediction EcolC_1353 b2299 yfcD predicted NUDIX hydrolase - -l 0.44 0.47 0.14 0.17 0.806 EcolC_1354 b2298 yfcC predicted inner membrane protein POORLY Function -0.09 -0.25 0.06 -0.11 0.211 CHARACTERIZ unknown ED EcolC_1355 b2297 pta phosphate acetyltransferase POORLY General -0.53 0.32 -0.17 0.68 0.003 CHARACTERIZ function ED prediction EcolC_1356 b2296 ackA acetate kinase A and propionate kinase 2 METABOLISM Energyl -0.88 0.22 -0.02 1.08 0.003 production and conversion EcolC_1357 b2295 yfbV inner membrane protein, UPF0208 family POORLY Function -0.09 -0.04 0.26 0.31 0.680 CHARACTERIZ unknown ED EcolC_1358 b2294 yfbU conserved protein, UPF0304 family POORLY Function -1.09 -0.58 -0.24 0.28 0.005 CHARACTERIZ unknown ED EcolC_1359 b2293 yfbT sugar phosphatas POORLY General -1.07 -0.14 -0.21 0.72 0.024 CHARACTERIZ function ED prediction EcolC_1360 b2292 yfbS predicted transporter METABOLISM Inorganicl ion 0.05 0.02 0.31 0.27 0.946 transport and metabolism EcolC_1361 b2291 yfbR 5'-nucleotidase POORLY General 0.08 0.44 0.33 0.69 0.120 CHARACTERIZ function ED prediction EcolC_1362 b2290 alaA valine-pyruvate aminotransferase 2 METABOLISM Aminol acid 0.62 0.50 0.29 0.18 0.226 transport and metabolism EcolC_1363 b2289 lrhA DNA-binding transcriptional repressor of INFORMATION Transcription 0.82 0.22 -0.08 -0.68 0.044 flagellar, motility and chemotaxis genes STORAGE AND PROCESSING EcolC_1364 b2288 nuoA NADH:ubiquinone oxidoreductase, METABOLISM Energy 2.27 0.45 0.39 -1.43 0.003 membrane subunit A production and conversion EcolC_1365 b2287 nuoB NADH:ubiquinone oxidoreductase, chain METABOLISM Energy 1.96 0.63 0.43 -0.90 0.011 B production and conversion EcolC_1366 b2286 nuoC NADH:ubiquinone oxidoreductase, fused METABOLISM Energy 2.01 0.63 0.30 -1.09 0.002 CD subunit production and conversion EcolC_1368 b2284 nuoF NADH:ubiquinone oxidoreductase, chain F METABOLISM Energy 1.23 0.53 0.18 -0.52 0.010 production and conversion EcolC_1369 b2283 nuoG NADH:ubiquinone oxidoreductase, chain METABOLISM Energy 1.43 0.44 0.24 -0.74 0.005 G production and conversion EcolC_1370 b2282 nuoH NADH:ubiquinone oxidoreductase, METABOLISM Energy 1.49 0.60 0.32 -0.56 0.003 membrane subunit H production and conversion EcolC_1371 b2281 nuoI NADH:ubiquinone oxidoreductase, chain I METABOLISM Energy 1.49 1.11 0.20 -0.18 0.126 production and conversion EcolC_1372 b2280 nuoJ NADH:ubiquinone oxidoreductase, METABOLISM Energy 1.14 1.00 0.18 0.04 0.462 membrane subunit J production and conversion EcolC_1373 b2279 nuoK NADH:ubiquinone oxidoreductase, METABOLISM Energy 1.36 1.38 0.19 0.21 0.884 membrane subunit K production and conversion EcolC_1374 b2278 nuoL NADH:ubiquinone oxidoreductase, METABOLISM Energy 0.98 1.18 0.15 0.35 0.208 membrane subunit L production and conversion EcolC_1375 b2277 nuoM NADH:ubiquinone oxidoreductase, METABOLISM Energy 1.14 1.58 0.06 0.49 0.026 membrane subunit M production and conversion EcolC_1376 b2276 nuoN NADH:ubiquinone oxidoreductase, METABOLISM Energy 0.56 0.94 0.17 0.54 0.836 membrane subunit N production and conversion EcolC_1377 b2272 yfbM conserved protein, DUF1877 family - - 0.39 0.40 0.21 0.22 0.850 EcolC_1380 b2268 rbn RNase BN, tRNA processing enzyme POORLY General 0.05 0.08 0.15 0.18 0.937 CHARACTERIZ function ED prediction l EcolC_1381 b2267 elaA predicted acyltransferase with acyl-CoA N- POORLY General -0.29 -0.22 -0.21 -0.14 0.573 acyltransferase domain CHARACTERIZ function ED prediction EcolC_1382 b2266 elaB ribosome-binding protein, probably POORLY Functionl -0.03 -0.32 0.27 -0.02 0.046 membrane-anchored, function unknown CHARACTERIZ unknown ED EcolC_1383 b2265 menF isochorismate synthase 2 METABOLISM Coenzyme 0.28 0.13 0.22 0.07 0.901 transport and metabolism EcolC_1384 b2264 menD 2-succinyl-5-enolpyruvyl-6-hydroxy-3- METABOLISM Coenzyme 0.48 0.37 0.00 -0.11 0.229 cyclohexene-1-carboxylate synthase; transport and SEPHCHC synthase metabolism EcolC_1385 b2263 menH 2-succinyl-6-hydroxy-2, 4-cyclohexadiene- POORLY General 0.02 -0.05 -0.13 -0.20 0.483 1-carboxylate synthase CHARACTERIZ function ED prediction EcolC_1386 b2262 menB dihydroxynaphthoic acid synthetase METABOLISM Coenzymel -0.28 0.32 -0.18 0.42 0.027 transport and metabolism EcolC_1387 b2261 menC O-succinylbenzoyl-CoA synthase METABOLISM Coenzyme -0.31 0.21 -0.11 0.40 0.118 transport and metabolism EcolC_1388 b2260 menE O-succinylbenzoate-CoA ligase METABOLISM Lipid 0.11 0.19 0.12 0.20 0.944 transport and metabolism EcolC_1389 b2259 pmrD inactive two-component system connector - - 0.61 0.01 0.02 -0.58 0.051 protein EcolC_1390 b2258 arnF undecaprenyl phosphate-alpha-L-ara4N - - 0.91 0.19 0.21 -0.51 0.002 exporter; flippase ArnEF subunit EcolC_1391 b4544 arnE undecaprenyl phosphate-alpha-L-ara4N - - 0.33 0.27 0.16 0.10 0.641 exporter; flippase ArnEF subunit EcolC_1392 b2257 arnT 4-amino-4-deoxy-L-arabinose transferase CELLULAR Cell -0.51 -0.57 -0.29 -0.36 0.784 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1393 b2256 arnD undecaprenyl phosphate-alpha-L-ara4FN METABOLISM Carbohydrate 0.02 0.07 0.22 0.27 0.529 deformylase transport and metabolism EcolC_1394 b2255 arnA fused UDP-L-Ara4N INFORMATION Translation, -0.10 -0.05 0.29 0.35 0.909 formyltransferase/UDP-GlcA C-4'- STORAGE AND ribosomal decarboxylase PROCESSING structure and biogenesis EcolC_1395 b2254 arnC undecaprenyl phosphate-L-Ara4FN CELLULAR Cell 0.04 -0.34 0.28 -0.09 0.107 transferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1397 b2252 ais predicted LPS core heptose(II)-phosphate - - -0.14 -0.14 0.01 0.01 0.923 phosphatase EcolC_1398 b2251 nudI nucleoside triphosphatase - - 0.11 0.16 0.05 0.11 0.686 EcolC_1399 b2250 yfaZ outer membrane protein, possible porin - - -0.08 -0.07 -0.08 -0.08 0.579 EcolC_1400 b2249 yfaY conserved protein POORLY General -0.22 -0.13 0.10 0.19 0.738 CHARACTERIZ function ED prediction EcolC_1401 b2248 rhmR predicted DNA-binding transcriptional INFORMATION Transcriptionl 0.44 0.31 0.18 0.05 0.640 regulator for the rhm operon STORAGE AND PROCESSING EcolC_1402 b2247 rhmD L-rhamnonate dehydratase CELLULAR Cell 0.36 0.47 0.34 0.46 0.475 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1403 b2246 rhmT predicted L-rhamnonate transporter METABOLISM Carbohydrate 0.13 0.38 0.22 0.47 0.228 transport and metabolism EcolC_1404 b2245 rhmA 2-keto-3-deoxy-L-rhamnonate aldolase METABOLISM Carbohydrate 0.02 0.16 0.22 0.36 0.864 transport and metabolism EcolC_1406 b2244 yfaD conserved protein POORLY Function -0.02 -0.07 -0.13 -0.18 0.547 CHARACTERIZ unknown ED EcolC_1408 b2243 glpC anaerobic sn-glycerol-3-phosphate METABOLISM Energy 1.34 2.39 0.78 1.83 0.003 dehydrogenase, C subunit, 4Fe-4S iron- production sulfur cluster and conversion EcolC_1409 b2242 glpB sn-glycerol-3-phosphate dehydrogenase METABOLISM Amino acid 1.70 2.81 0.76 1.87 0.001 (anaerobic), membrane anchor subunit transport and metabolism EcolC_1410 b2241 glpA sn-glycerol-3-phosphate dehydrogenase METABOLISM Energy 2.07 2.98 0.51 1.42 0.002 (anaerobic), large subunit, FAD/NAD(P)- production binding and conversion EcolC_1411 b2240 glpT sn-glycerol-3-phosphate transporter METABOLISM Carbohydrate 3.49 2.86 0.36 -0.27 0.013 transport and metabolism EcolC_1412 b2239 glpQ periplasmic glycerophosphodiester METABOLISM Energy 2.01 1.46 0.30 -0.25 0.306 phosphodiesterase production and conversion EcolC_1413 b2238 yfaH - - - 1.47 2.27 0.63 1.44 0.041 EcolC_1414 b2237 inaA conserved protein, acid-induced - - 1.99 0.95 0.41 -0.63 0.004 EcolC_1415 b2236 yfaE ferredoxin involved with ribonucleotide METABOLISM Energy 0.86 0.35 -0.04 -0.56 0.026 reductase diferric-tyrosyl radical (Y*) production cofactor maintenance and conversion EcolC_1416 b2235 nrdB ribonucleoside-diphosphate reductase 1, METABOLISM Nucleotide -0.70 -0.36 -0.39 -0.05 0.004 beta subunit, ferritin-like protein transport and metabolism EcolC_1417 b2234 nrdA ribonucleoside-diphosphate reductase 1, METABOLISM Nucleotide -0.18 -0.11 -0.02 0.05 0.644 alpha subunit transport and metabolism EcolC_1418 b2233 yfaL adhesin CELLULAR Cell -0.17 -0.30 -0.14 -0.26 0.441 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1419 b2232 ubiG bifunctional 3-demethylubiquinone-9 3- METABOLISM Coenzyme 0.49 0.51 0.21 0.22 0.810 methyltransferase/ 2-octaprenyl-6-hydroxy transport and phenol methylase metabolism EcolC_1420 b2231 gyrA DNA gyrase (type II topoisomerase), INFORMATION Replication, 0.18 0.20 -0.21 -0.18 0.439 subunit A STORAGE AND recombination PROCESSING and repair EcolC_1421 b2230 yfaA DUF2138 family protein, function POORLY Function 0.07 -0.11 -0.02 -0.20 0.099 unknown CHARACTERIZ unknown ED EcolC_1422 b2229 yfaT DUF1175 family protein, function POORLY Function -0.04 -0.07 0.05 0.01 0.786 unknown CHARACTERIZ unknown ED EcolC_1423 b4500 yfaS - - - 0.14 0.23 0.13 0.22 0.312 EcolC_1424 b2226 yfaQ tandem DUF2300 domain protein, function POORLY Function -0.07 -0.03 -0.05 -0.02 0.537 unknown CHARACTERIZ unknown ED EcolC_1425 b2225 yfaP DUF2135 family protein, function POORLY Function -0.07 -0.08 0.00 -0.01 0.743 unknown CHARACTERIZ unknown ED EcolC_1426 b2224 atoB acetyl-CoA acetyltransferase METABOLISM Lipid 0.02 0.02 -0.02 -0.03 0.791 transport and metabolism EcolC_1427 b2223 atoE short chain fatty acid transporter METABOLISM Lipid -0.07 -0.08 -0.12 -0.14 0.901 transport and metabolism EcolC_1428 b2222 atoA acetyl-CoA:acetoacetyl-CoA transferase, METABOLISM Lipid -0.15 -0.17 -0.13 -0.15 0.821 beta subunit transport and metabolism EcolC_1429 b2221 atoD acetyl-CoA:acetoacetyl-CoA transferase, METABOLISM Lipid -0.15 -0.16 -0.12 -0.13 0.980 alpha subunit transport and metabolism EcolC_1430 b2220 atoC fused response regulator of ato operon, in CELLULAR Signal 0.69 1.06 -0.10 0.27 0.842 two-component system with AtoS: PROCESSES transduction response regulator/sigma54 interaction AND mechanisms protein SIGNALING EcolC_1431 b2219 atoS sensory histidine kinase in two-component CELLULAR Signal 0.85 0.66 0.07 -0.12 0.193 regulatory system with AtoC PROCESSES transduction AND mechanisms SIGNALING EcolC_1432 b2218 rcsC hybrid sensory kinase in two-component CELLULAR Signal 0.54 0.16 0.06 -0.32 0.033 regulatory system with RcsB and YojN PROCESSES transduction AND mechanisms SIGNALING EcolC_1433 b2217 rcsB DNA-binding response regulator in two- CELLULAR Signal 0.02 0.05 0.10 0.14 0.893 component regulatory system with RcsC PROCESSES transduction and YojN AND mechanisms SIGNALING EcolC_1434 b2216 rcsD phosphotransfer intermediate protein in CELLULAR Signal 0.68 0.37 0.24 -0.07 0.373 two-component regulatory system with PROCESSES transduction RcsBC AND mechanisms SIGNALING EcolC_1436 b2214 apbE putative flavin transferase, lipoprotein METABOLISM Coenzyme 0.15 0.17 0.19 0.22 0.952 required for thiamine synthesis transport and metabolism EcolC_1437 b2213 ada fused DNA-binding transcriptional dual METABOLISM Nucleotide 0.36 0.27 0.19 0.10 0.561 regulator/O6-methylguanine-DNA transport and methyltransferase metabolism EcolC_1439 b2211 yojI microcin J25 efflux pump, TolC- METABOLISM Secondary 0.12 -0.01 0.07 -0.06 0.469 dependent; fused ABC transporter metabolites permease and ATP-binding components biosynthesis, transport and catabolism EcolC_1440 b2210 mqo malate dehydrogenase, FAD/NAD(P)- POORLY General 0.03 -0.09 0.15 0.03 0.729 binding domain CHARACTERIZ function ED prediction EcolC_1441 b2209 eco ecotin, a serine protease inhibitor POORLY Generall 0.03 0.03 -0.25 -0.25 0.911 CHARACTERIZ function ED prediction EcolC_1442 b2208 napF ferredoxin-type protein, role in electron METABOLISM Energyl 0.08 0.22 0.05 0.18 0.621 transfer to periplasmic nitrate reductase production NapA and conversion EcolC_1443 b2207 napD assembly protein for periplasmic nitrate METABOLISM Inorganic ion 0.15 0.23 0.17 0.25 0.620 reductase transport and metabolism EcolC_1444 b2206 napA nitrate reductase, periplasmic, large subunit METABOLISM Energy 0.10 0.24 0.17 0.30 0.216 production and conversion EcolC_1445 b2205 napG ferredoxin-type protein essential for POORLY General -0.25 0.01 -0.05 0.22 0.257 electron transfer from ubiquinol to CHARACTERIZ function periplasmic nitrate reductase (NapAB) ED prediction EcolC_1446 b2204 napH ferredoxin-type protein essential for METABOLISM Energyl -0.18 0.00 0.20 0.38 0.327 electron transfer from ubiquinol to production periplasmic nitrate reductase (NapAB) and conversion EcolC_1447 b2203 napB nitrate reductase, small, cytochrome C550 METABOLISM Energy -0.11 0.07 0.20 0.39 0.830 subunit, periplasmic production and conversion EcolC_1448 b2202 napC quinol dehydrogenase, electron source for METABOLISM Energy 0.11 0.20 0.17 0.26 0.923 NapAB production and conversion EcolC_1449 b2201 ccmA heme exporter subunit CELLULAR Posttranslatio 0.10 -0.08 0.13 -0.05 0.614 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1450 b2200 ccmB heme exporter subunit CELLULAR Posttranslatio 0.68 0.46 0.38 0.16 0.220 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1451 b2199 ccmC heme exporter subunit CELLULAR Posttranslatio 0.67 0.60 0.33 0.27 0.603 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1452 b2198 ccmD cytochrome c biogenesis protein CELLULAR Intracellular 0.17 0.20 0.08 0.11 0.883 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_1453 b2197 ccmE periplasmic heme chaperone CELLULAR Posttranslatio 0.30 0.19 -0.09 -0.20 0.822 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1454 b2196 ccmF heme lyase, CcmF subunit CELLULAR Posttranslatio 0.38 0.06 -0.15 -0.47 0.690 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1455 b2195 dsbE periplasmic thioredoxin of cytochrome c- CELLULAR Posttranslatio 0.13 0.46 0.13 0.46 0.247 type biogenesis PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1456 b2194 ccmH heme lyase, CcmH subunit CELLULAR Posttranslatio 0.15 0.25 0.26 0.36 0.302 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1457 b2193 narP DNA-binding response regulator in two- CELLULAR Signal 0.35 0.47 0.19 0.31 0.478 component regulatory system with NarQ or PROCESSES transduction NarX AND mechanisms SIGNALING EcolC_1459 b2188 yejM predicted hydrolase, inner membrane POORLY General 0.13 0.00 -0.15 -0.29 0.134 CHARACTERIZ function ED prediction l EcolC_1460 b2187 yejL conserved protein, UPF0352 family POORLY Function 0.44 0.50 0.12 0.18 0.381 CHARACTERIZ unknown ED EcolC_1461 b2186 yejK spermidine nucleoid-associated protein POORLY General 0.13 0.21 -0.02 0.06 0.830 CHARACTERIZ function ED prediction EcolC_1462 b2185 rplY 50S ribosomal subunit protein L25 INFORMATION Translation,l -0.83 -0.64 0.24 0.42 0.251 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1463 b2184 yejH predicted ATP-dependent DNA or RNA INFORMATION Transcription 0.59 0.53 -0.15 -0.20 0.589 helicase STORAGE AND PROCESSING EcolC_1464 b2183 rsuA 16S rRNA pseudouridine(516) synthase INFORMATION Translation, 0.13 0.42 0.01 0.30 0.223 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1465 b2182 bcr bicyclomycin/cysteine/sulfonamide efflux METABOLISM Carbohydrate -0.01 -0.21 -0.07 -0.27 0.729 transporter transport and metabolism EcolC_1466 b2181 yejG predicted protein - - -0.10 -0.31 0.69 0.49 0.246 EcolC_1467 b2180 yejF microcin C transporter, ATP-binding POORLY General 0.48 0.77 0.22 0.51 0.022 subunit; ABC family CHARACTERIZ function ED prediction EcolC_1468 b2179 yejE microcin C transporter YejABEF, POORLY Generall -0.20 -0.03 -0.27 -0.10 0.827 permease subunit; ABC family CHARACTERIZ function ED prediction EcolC_1469 b2178 yejB microcin C transporter YejABEF, POORLY Generall 0.20 0.16 0.06 0.02 0.535 permease subunit; ABC family CHARACTERIZ function ED prediction l EcolC_1470 b2177 yejA microcin C transporter YejABEF, METABOLISM Amino acid 0.23 0.26 0.16 0.18 0.814 periplasmic binding protein; ABC family transport and metabolism EcolC_1471 b2176 rtn resistance protein for phages lambda and CELLULAR Signal 0.15 0.07 0.18 0.10 0.715 N4, when overexpressed, predicted PROCESSES transduction membrane-anchored cyclic-di-GMP AND mechanisms phosphodiesterase SIGNALING EcolC_1472 b2175 mepS murein DD-endopeptidase, space-maker CELLULAR Cell -0.37 0.30 -0.44 0.23 0.064 hydrolase, mutational suppressor of prc PROCESSES wall/membran thermosensitivity, outer membrane AND e/envelope lipoprotein SIGNALING biogenesis EcolC_1473 b2174 lpxT lipid A 1-diphosphate synthase; METABOLISM Lipid -0.01 -0.12 -0.17 -0.28 0.690 undecaprenyl pyrophosphate:lipid A 1- transport and phosphate phosphotransferase metabolism EcolC_1474 b2173 yeiR Zn-stimulated GTPase involved in zinc POORLY General 0.10 -0.10 -0.03 -0.23 0.284 homeostasis; mutants are cadmium and CHARACTERIZ function EDTA sensitive; Zn(2+) binding protein ED prediction EcolC_1475 b2172 yeiQ predicted D-mannonate oxidoreductase, METABOLISM Carbohydratel -0.27 -0.70 0.51 0.08 0.022 NAD-dependent transport and metabolism EcolC_1476 b2171 yeiP elongation factor P-like protein INFORMATION Translation, -0.12 0.22 0.28 0.62 0.177 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1477 b4502 yeiW UPF0153 cysteine cluster protein, function - - -0.20 0.07 0.14 0.41 0.138 unknown EcolC_1478 b2170 setB lactose/glucose efflux system METABOLISM Carbohydrate -0.14 0.01 0.03 0.18 0.859 transport and metabolism EcolC_1479 b2169 fruB fused fructose-specific PTS enzymes: IIA METABOLISM Carbohydrate 0.42 0.79 0.36 0.73 0.175 component/HPr component transport and metabolism EcolC_1480 b2168 fruK fructose-1-phosphate kinase METABOLISM Carbohydrate 0.14 1.02 0.45 1.33 0.002 transport and metabolism EcolC_1481 b2167 fruA fused fructose-specific PTS enzymes: METABOLISM Carbohydrate 0.33 0.95 0.22 0.83 0.057 IIBcomponent/IIC components transport and metabolism EcolC_1482 b2166 psuK pseudouridine kinase METABOLISM Carbohydrate -0.15 -0.18 -0.11 -0.14 0.697 transport and metabolism EcolC_1483 b2165 psuG pseudouridine 5'-phosphate glycosidase METABOLISM Secondary -0.17 -0.07 -0.18 -0.08 0.438 metabolites biosynthesis, transport and catabolism EcolC_1484 b2164 psuT predicted nucleoside transporter METABOLISM Nucleotide 0.12 0.04 -0.04 -0.12 0.479 transport and metabolism EcolC_1485 b2163 yeiL DNA-binding transcriptional activator of CELLULAR Signal -0.48 -0.31 -0.34 -0.16 0.430 stationary phase nitrogen survival PROCESSES transduction AND mechanisms SIGNALING EcolC_1486 b2162 rihB ribonucleoside hydrolase 2 METABOLISM Nucleotide 0.02 0.13 0.07 0.18 0.625 transport and metabolism EcolC_1488 b2160 yeiI predicted kinase METABOLISM Carbohydrate 0.58 0.41 0.24 0.07 0.808 transport and metabolism EcolC_1489 b2159 nfo endonuclease IV with intrinsic 3'-5' INFORMATION Replication, 0.42 -0.05 -0.32 -0.79 0.013 exonuclease activity STORAGE AND recombination PROCESSING and repair EcolC_1490 b2158 yeiH inner membrane protein, UPF0324 family POORLY Function 0.21 0.25 0.15 0.19 0.745 CHARACTERIZ unknown ED EcolC_1491 b2157 yeiE predicted DNA-binding transcriptional INFORMATION Transcription 0.40 0.48 0.38 0.46 0.325 regulator STORAGE AND PROCESSING EcolC_1492 b2156 lysP lysine transporter METABOLISM Amino acid 0.09 -0.03 0.22 0.10 0.348 transport and metabolism EcolC_1493 b2155 cirA catecholate siderophore receptor CirA METABOLISM Inorganic ion 0.20 0.15 0.14 0.09 0.860 transport and metabolism EcolC_1494 b2154 yeiG S-formylglutathione hydrolase POORLY General 0.89 0.58 0.00 -0.31 0.114 CHARACTERIZ function ED prediction EcolC_1495 b2153 folE GTP cyclohydrolase I METABOLISM Coenzymel 0.23 0.23 -0.03 -0.03 0.579 transport and metabolism EcolC_1496 b2152 yeiB predicted inner membrane protein POORLY Function -0.34 -0.27 -0.19 -0.11 0.247 CHARACTERIZ unknown ED EcolC_1497 b2151 galS DNA-binding transcriptional repressor INFORMATION Transcription 0.71 0.48 0.60 0.36 0.312 STORAGE AND PROCESSING EcolC_1498 b2150 mglB methyl-galactoside transporter subunit METABOLISM Carbohydrate 0.76 0.32 -0.32 -0.77 0.015 transport and metabolism EcolC_1499 b2149 mglA fused methyl-galactoside transporter METABOLISM Carbohydrate 0.83 0.19 0.30 -0.33 0.499 subunits of ABC superfamily: ATP-binding transport and components metabolism EcolC_1500 b2148 mglC methyl-galactoside transporter subunit METABOLISM Carbohydrate 0.70 -0.44 -0.59 -1.73 0.017 transport and metabolism EcolC_1501 b2147 preA dihydropyrimidine dehydrogenase, NADH- METABOLISM Nucleotide -0.07 -0.14 0.12 0.05 0.583 dependent, subunit C transport and metabolism EcolC_1502 b2146 preT dihydropyrimidine dehydrogenase, NADH- METABOLISM Amino acid -1.35 -0.92 0.21 0.64 0.546 dependent, subunit N transport and metabolism EcolC_1503 b2145 yeiS conserved protein, DUF2542 family - - -0.86 -0.53 -0.85 -0.53 0.379 EcolC_1504 b2144 sanA vancomycin high temperature exclusion POORLY Function 0.22 0.12 0.12 0.02 0.937 protein; mutants have a defective envelope CHARACTERIZ unknown more permeable to vancomycin at 42 ED degrees EcolC_1505 b2143 cdd cytidine/deoxycytidine deaminase METABOLISM Nucleotide 0.56 1.30 0.10 0.84 0.032 transport and metabolism EcolC_1506 b2142 yohK inner membrane protein, LrgB family CELLULAR Cell 0.01 -0.08 0.08 -0.01 0.414 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1507 b2141 yohJ inner membrane protein, UPF0299 family POORLY General -0.35 -0.13 -0.06 0.17 0.100 CHARACTERIZ function ED prediction EcolC_1508 b2140 dusC tRNA-dihydrouridine synthase C INFORMATION Translation,l 0.13 -0.04 0.07 -0.10 0.273 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1510 b2137 yohF predicted oxidoreductase with NAD(P)- METABOLISM Lipid -0.24 0.08 0.15 0.47 0.657 binding Rossmann-fold domain transport and metabolism EcolC_1511 b2136 yohD inner membrane protein, DedA family POORLY Function -0.15 -0.06 0.32 0.40 0.340 CHARACTERIZ unknown ED EcolC_1512 b2135 yohC inner membrane protein, Yip1 family - - -0.08 -0.38 0.29 -0.01 0.089 EcolC_1513 b2134 pbpG D-alanyl-D-alanine endopeptidase CELLULAR Cell 0.36 0.40 0.06 0.10 0.915 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1514 b2133 dld D-lactate dehydrogenase, FAD-binding, METABOLISM Energy -0.08 0.32 -0.44 -0.05 0.037 NADH independent production and conversion EcolC_1515 b2132 bglX beta-D-glucoside glucohydrolase, METABOLISM Carbohydrate -0.08 -0.19 -0.10 -0.21 0.691 periplasmic transport and metabolism EcolC_1517 b2130 yehY predicted transporter subunit: membrane METABOLISM Amino acid 0.25 0.13 0.04 -0.08 0.379 component of ABC superfamily transport and metabolism EcolC_1518 b2129 yehX predicted transporter subunit: ATP-binding METABOLISM Amino acid 0.23 0.20 0.21 0.19 0.944 component of ABC superfamily transport and metabolism EcolC_1519 b2128 yehW predicted transporter subunit: membrane METABOLISM Amino acid -0.04 0.10 -0.02 0.12 0.462 component of ABC superfamily transport and metabolism EcolC_1520 b2127 mlrA DNA-binding transcriptional regulator INFORMATION Transcription 0.24 0.34 0.34 0.44 0.659 STORAGE AND PROCESSING EcolC_1521 b2126 yehU predicted sensory kinase in two-component CELLULAR Signal 1.40 1.31 0.06 -0.04 0.734 system with YehT, inner membrane protein PROCESSES transduction AND mechanisms SIGNALING EcolC_1522 b2125 yehT predicted response regulator in two- INFORMATION Transcription 0.42 0.59 0.08 0.25 0.748 component system withYehU STORAGE AND PROCESSING EcolC_1523 b2124 yehS conserved protein, DUF1456 family POORLY Function 0.40 0.84 0.24 0.68 0.175 CHARACTERIZ unknown ED EcolC_1524 b2123 yehR lipoprotein, DUF1307 family POORLY Function -0.02 0.11 0.00 0.14 0.708 CHARACTERIZ unknown ED EcolC_1528 b2120 yehM predicted protein - - 0.02 -0.09 -0.12 -0.23 0.604 EcolC_1530 b4541 yehK predicted protein - - -0.04 -0.03 -0.11 -0.10 0.887 EcolC_1531 b2118 yehI conserved protein - - 0.05 0.19 0.16 0.31 0.986 EcolC_1532 b4499 yehH - - - 0.21 0.03 0.07 -0.12 0.398 EcolC_1533 b2114 metG methionyl-tRNA synthetase INFORMATION Translation, -0.07 0.40 0.02 0.49 0.107 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1534 b2113 mrp antiporter inner membrane protein CELLULAR Cell cycle 0.76 1.07 -0.13 0.19 0.041 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_1535 b2112 yehE predicted protein - - -0.86 -0.56 -0.16 0.14 0.198 EcolC_1536 b2111 yehD predicted fimbrial-like adhesin protein CELLULAR Cell motility 0.02 -0.24 0.20 -0.05 0.340 PROCESSES AND SIGNALING EcolC_1537 b2110 yehC predicted periplasmic pilin chaperone CELLULAR Cell motility 0.05 -0.10 0.28 0.13 0.046 PROCESSES AND SIGNALING EcolC_1538 b2109 yehB predicted outer membrane protein CELLULAR Cell motility 0.16 -0.01 0.14 -0.03 0.439 PROCESSES AND SIGNALING EcolC_1539 b2108 yehA predicted fimbrial-like adhesin protein - - -0.55 -0.63 -0.72 -0.81 0.574 EcolC_1540 b2107 rcnB periplasmic modulator of Ni and Co efflux POORLY Function 0.41 0.48 0.02 0.10 0.698 CHARACTERIZ unknown ED EcolC_1541 b2106 rcnA membrane protein conferring nickel and POORLY General 0.01 0.02 -0.10 -0.08 0.903 cobalt resistance CHARACTERIZ function ED prediction EcolC_1542 b2105 rcnR DNA-binding transcriptional repressor of POORLY Functionl 0.50 0.66 0.43 0.59 0.883 rcnA CHARACTERIZ unknown ED EcolC_1543 b2104 thiM hydoxyethylthiazole kinase METABOLISM Coenzyme 0.06 0.05 0.23 0.23 0.938 transport and metabolism EcolC_1544 b2103 thiD bifunctional hydroxy-methylpyrimidine METABOLISM Coenzyme 0.04 0.19 0.23 0.37 0.753 kinase/ hydroxy-phosphomethylpyrimidine transport and kinase metabolism EcolC_1545 b2102 yegX predicted hydrolase CELLULAR Cell -0.07 0.03 0.01 0.12 0.986 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1546 b2101 yegW predicted DNA-binding transcriptional INFORMATION Transcription 0.02 -0.10 -0.01 -0.13 0.625 regulator STORAGE AND PROCESSING EcolC_1548 b2099 yegU predicted hydrolase CELLULAR Posttranslatio -0.15 -0.09 -0.08 -0.01 0.467 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1549 b2098 yegT nucleoside transporter, low affinity - - -0.22 -0.13 -0.16 -0.07 0.780 EcolC_1550 b2097 fbaB fructose-bisphosphate aldolase class I METABOLISM Carbohydrate -0.29 0.19 -0.29 0.19 0.047 transport and metabolism EcolC_1551 b2096 gatY D-tagatose 1,6-bisphosphate aldolase 2, METABOLISM Carbohydrate 0.39 0.39 0.15 0.16 0.970 catalytic subunit transport and metabolism EcolC_1552 b2095 gatZ D-tagatose 1,6-bisphosphate aldolase 2, METABOLISM Carbohydrate 0.23 0.43 0.22 0.43 0.602 subunit transport and metabolism EcolC_1553 b2094 gatA galactitol-specific enzyme IIA component METABOLISM Carbohydrate -0.16 -0.14 -0.16 -0.13 0.756 of PTS transport and metabolism EcolC_1554 b2093 gatB galactitol-specific enzyme IIB component METABOLISM Carbohydrate -0.02 -0.21 -0.09 -0.28 0.495 of PTS transport and metabolism EcolC_1555 b2092 gatC - - - -0.42 -0.31 -0.40 -0.30 0.869 EcolC_1556 b2091 gatD galactitol-1-phosphate dehydrogenase, Zn- METABOLISM Amino acid 0.05 0.49 -0.04 0.40 0.778 dependent and NAD(P)-binding transport and metabolism EcolC_1557 b4498 gatR - - - 0.08 0.32 0.22 0.46 0.186 EcolC_1558 b2086 yegS phosphatidylglycerol kinase, metal- METABOLISM Lipid 0.11 -0.13 0.15 -0.09 0.273 dependent transport and metabolism EcolC_1559 b2085 yegR predicted protein - - -0.09 0.07 0.18 0.34 0.664 EcolC_1560 b2081 yegQ predicted peptidase CELLULAR Posttranslatio 0.04 0.18 0.22 0.36 0.939 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1561 b2080 yegP conserved protein, UPF0339 family POORLY Function 0.23 0.15 0.18 0.09 0.578 CHARACTERIZ unknown ED EcolC_1562 b2079 baeR DNA-binding response regulator in two- CELLULAR Signal -0.12 0.07 0.10 0.30 0.206 component regulatory system with BaeS PROCESSES transduction AND mechanisms SIGNALING EcolC_1563 b2078 baeS sensory histidine kinase in two-component CELLULAR Signal 0.19 -0.07 0.04 -0.22 0.474 regulatory system with BaeR PROCESSES transduction AND mechanisms SIGNALING EcolC_1564 b2077 mdtD putative arabinose efflux transporter METABOLISM Carbohydrate 0.73 0.25 0.19 -0.29 0.058 transport and metabolism EcolC_1565 b2076 mdtC multidrug efflux system, subunit C CELLULAR Defense 0.02 -0.15 -0.05 -0.21 0.252 PROCESSES mechanisms AND SIGNALING EcolC_1566 b2075 mdtB multidrug efflux system, subunit B CELLULAR Defense 0.59 0.32 0.26 -0.02 0.112 PROCESSES mechanisms AND SIGNALING EcolC_1567 b2074 mdtA multidrug efflux system, subunit A CELLULAR Cell 0.13 -0.17 0.00 -0.29 0.342 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1568 b2073 yegL conserved protein POORLY General 0.13 0.14 0.17 0.18 0.856 CHARACTERIZ function ED prediction EcolC_1569 b2072 yegK predicted protein - -l -0.10 0.01 0.07 0.18 0.720 EcolC_1571 b2070 yegI conserved protein POORLY General -0.16 -0.20 -0.06 -0.11 0.846 CHARACTERIZ function ED prediction EcolC_1572 b2069 yegD predicted chaperone CELLULAR Posttranslatiol -0.06 -0.04 0.15 0.17 0.714 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1573 b2068 alkA 3-methyl-adenine DNA glycosylase II INFORMATION Replication, 0.25 0.49 0.29 0.54 0.382 STORAGE AND recombination PROCESSING and repair EcolC_1574 b2067 yegE predicted diguanylate cyclase, GGDEF CELLULAR Signal 0.22 0.12 0.10 0.00 0.829 domain signaling protein PROCESSES transduction AND mechanisms SIGNALING EcolC_1575 b2066 udk uridine/cytidine kinase METABOLISM Nucleotide 0.25 0.16 0.21 0.12 0.916 transport and metabolism EcolC_1576 b2065 dcd 2'-deoxycytidine 5'-triphosphate deaminase METABOLISM Nucleotide 0.19 0.35 0.00 0.15 0.251 transport and metabolism EcolC_1577 b2064 asmA predicted assembly protein CELLULAR Cell 0.11 0.26 -0.13 0.01 0.947 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1578 b2063 yegH inner membrane protein POORLY General 0.29 -0.14 0.25 -0.18 0.006 CHARACTERIZ function ED prediction EcolC_1579 b2062 wza lipoprotein required for capsular CELLULAR Celll -0.21 -0.12 -0.02 0.08 0.407 polysaccharide translocation through the PROCESSES wall/membran outer membrane AND e/envelope SIGNALING biogenesis EcolC_1580 b2061 wzb protein-tyrosine phosphatase CELLULAR Signal 0.35 0.70 0.39 0.75 0.212 PROCESSES transduction AND mechanisms SIGNALING EcolC_1581 b2060 wzc protein- CELLULAR Cell -0.08 0.07 0.14 0.29 0.293 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1582 b2059 wcaA predicted glycosyl transferase CELLULAR Cell -0.13 -0.04 -0.07 0.02 0.431 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1583 b2058 wcaB predicted acyl transferase METABOLISM Amino acid 0.01 -0.03 0.01 -0.03 0.746 transport and metabolism EcolC_1584 b2057 wcaC predicted glycosyl transferase CELLULAR Cell 0.01 -0.05 -0.08 -0.15 0.484 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1585 b2056 wcaD predicted colanic acid polymerase - - -0.04 -0.06 -0.02 -0.04 0.781 EcolC_1587 b2054 wcaF predicted acyl transferase POORLY General -0.09 -0.15 -0.08 -0.14 0.378 CHARACTERIZ function ED prediction l EcolC_1588 b2053 gmd GDP-D-mannose dehydratase, NAD(P)- CELLULAR Cell 0.05 -0.05 -0.07 -0.18 0.951 binding PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1589 b2052 wcaG bifunctional GDP-fucose synthetase: GDP- CELLULAR Cell 0.15 0.24 0.09 0.17 0.498 4-dehydro-6-deoxy-D-mannose epimerase/ PROCESSES wall/membran GDP-4-dehydro-6-L-deoxygalactose AND e/envelope reductase SIGNALING biogenesis EcolC_1590 b2051 wcaH GDP-mannose mannosyl hydrolase METABOLISM Nucleotide -0.06 0.14 -0.07 0.12 0.289 transport and metabolism EcolC_1592 b2049 cpsB mannose-1-phosphate guanyltransferase CELLULAR Cell -0.02 -0.13 -0.15 -0.27 0.386 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1594 b2047 wcaJ colanic biosynthesis UDP-glucose lipid CELLULAR Cell -0.12 -0.17 -0.23 -0.28 0.576 carrier transferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1595 b2046 wzxC predicted colanic acid exporter POORLY General -0.24 -0.13 -0.02 0.09 0.773 CHARACTERIZ function ED prediction EcolC_1597 b2044 wcaL predicted glycosyl transferase CELLULAR Celll -0.10 -0.11 -0.04 -0.05 0.748 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1603 b2039 rfbA glucose-1-phosphate thymidylyltransferase CELLULAR Cell -0.39 -0.06 -0.31 0.03 0.099 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1614 b2028 ugd UDP-glucose 6-dehydrogenase CELLULAR Cell -0.14 -0.11 -0.01 0.02 0.810 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1615 b2027 wzzB regulator of length of O-antigen component CELLULAR Cell -0.40 0.04 -0.14 0.30 0.227 of lipopolysaccharide chains PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1617 b2025 hisF imidazole glycerol phosphate synthase, METABOLISM Amino acid -0.20 -0.10 0.03 0.12 0.499 catalytic subunit with HisH transport and metabolism EcolC_1618 b2024 hisA N-(5'-phospho-L-ribosyl-formimino)-5- METABOLISM Amino acid -0.04 0.05 0.27 0.36 0.884 amino-1- (5'-phosphoribosyl)-4- transport and imidazolecarboxamide isomerase metabolism EcolC_1619 b2023 hisH imidazole glycerol phosphate synthase, METABOLISM Amino acid 0.01 -0.01 0.11 0.09 0.245 glutamine amidotransferase subunit with transport and HisF metabolism EcolC_1620 b2022 hisB fused histidinol- METABOLISM Amino acid 0.43 0.48 0.29 0.34 0.623 phosphatase/imidazoleglycerol-phosphate transport and dehydratase metabolism EcolC_1621 b2021 hisC histidinol-phosphate aminotransferase METABOLISM Amino acid 0.10 0.19 0.11 0.20 0.160 transport and metabolism EcolC_1622 b2020 hisD bifunctional histidinal dehydrogenase/ METABOLISM Amino acid 0.26 0.16 0.09 -0.01 0.768 histidinol dehydrogenase transport and metabolism EcolC_1623 b2019 hisG ATP phosphoribosyltransferase METABOLISM Amino acid -0.18 -0.15 0.04 0.07 0.858 transport and metabolism EcolC_1624 b2016 yeeZ predicted epimerase, with NAD(P)-binding CELLULAR Cell 0.16 0.08 0.05 -0.03 0.594 Rossmann-fold domain PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1625 b2015 yeeY predicted DNA-binding transcriptional INFORMATION Transcription 0.13 0.06 -0.05 -0.13 0.804 regulator STORAGE AND PROCESSING EcolC_1626 b2014 plaP putrescine importer, low affinity METABOLISM Amino acid -0.29 -0.21 -0.04 0.04 0.937 transport and metabolism EcolC_1627 b2013 yeeE inner membrane protein, UPF0394 family POORLY General -0.08 -0.07 -0.09 -0.08 0.796 CHARACTERIZ function ED prediction EcolC_1628 b2012 yeeD conserved protein CELLULAR Posttranslatiol 0.09 0.21 0.32 0.44 0.436 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1629 b2011 sbcB exonuclease I INFORMATION Replication, 0.62 0.16 -0.07 -0.53 0.312 STORAGE AND recombination PROCESSING and repair EcolC_1630 b2010 dacD D-alanyl-D-alanine carboxypeptidase CELLULAR Cell 0.09 0.33 0.25 0.49 0.069 (penicillin-binding protein 6b) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1631 b2009 sbmC DNA gyrase inhibitor INFORMATION Replication, 0.57 0.78 0.18 0.38 0.156 STORAGE AND recombination PROCESSING and repair EcolC_1632 b2008 yeeA inner membrane protein, FUSC family POORLY Function -0.17 0.01 -0.04 0.13 0.245 CHARACTERI unknown ZED EcolC_1635 b1993 cobU bifunctional cobinamide kinase/ METABOLISM Coenzyme 0.04 -0.21 0.32 0.07 0.709 cobinamide phosphate transport and metabolism EcolC_1637 b1991 cobT nicotinate-nucleotide-- METABOLISM Coenzyme -0.03 -0.15 0.11 -0.01 0.469 dimethylbenzimidazole transport and phosphoribosyltransferase metabolism EcolC_1638 b1990 erfK L,D-transpeptidase linking Lpp to murein POORLY Function -0.34 -0.51 0.41 0.24 0.157 CHARACTERIZ unknown ED EcolC_1657 b1988 nac DNA-binding transcriptional dual regulator INFORMATION Transcription -0.16 -0.19 -0.11 -0.13 0.892 of nitrogen assimilation STORAGE AND PROCESSING EcolC_1658 b1987 cbl DNA-binding transcriptional activator for INFORMATION Transcription -0.01 -0.02 0.10 0.09 0.966 the ssuEADCB and tauABCD operons STORAGE AND PROCESSING EcolC_1659 b1985 yeeO predicted multdrug exporter, MATE family CELLULAR Defense -0.06 -0.02 -0.14 -0.10 0.821 PROCESSES mechanisms AND SIGNALING EcolC_1660 b1983 yeeN conserved protein, UPF0082 family POORLY Function 0.01 0.02 0.05 0.06 0.976 CHARACTERIZ unknown ED EcolC_1661 b1982 amn AMP nucleosidase METABOLISM Nucleotide -0.32 -0.11 -0.20 0.01 0.067 transport and metabolism EcolC_1662 b1981 shiA shikimate transporter METABOLISM Carbohydrate -0.17 -0.15 0.10 0.12 0.666 transport and metabolism EcolC_1670 b1976 mtfA anti-repressor for DgsA(Mlc) POORLY Function 0.25 0.29 -0.15 -0.12 0.754 CHARACTERIZ unknown ED EcolC_1671 b1974 yodB cytochrome b561 homolog METABOLISM Energy -0.01 -0.04 0.19 0.16 0.947 production and conversion EcolC_1672 b1973 zinT zinc and cadmium binding protein, POORLY General -0.22 -0.19 0.04 0.08 0.997 periplasmic CHARACTERIZ function ED prediction EcolC_1673 b1972 yedZ inner membrane heme subunit for POORLY Functionl 0.38 0.53 0.16 0.32 0.154 periplasmic YedYZ reductase CHARACTERIZ unknown ED EcolC_1674 b1971 yedY membrane-anchored, periplasmic TMAO, POORLY General 0.02 -0.07 0.11 0.03 0.510 DMSO reductase CHARACTERIZ function ED prediction EcolC_1675 b1970 hiuH hydroxyisourate hydrolase POORLY Generall -0.05 0.16 0.06 0.28 0.218 CHARACTERIZ function ED prediction EcolC_1676 b1969 yedW predicted DNA-binding response regulator CELLULAR Signall 0.07 0.09 -0.02 0.00 0.648 in two-component system with YedV PROCESSES transduction AND mechanisms SIGNALING EcolC_1677 b1968 yedV predicted sensory kinase in two-component CELLULAR Signal 0.46 0.30 0.09 -0.07 0.826 regulatory system with YedW PROCESSES transduction AND mechanisms SIGNALING EcolC_1678 b1967 hchA glyoxalase III and Hsp31 molecular POORLY General 0.64 0.50 0.20 0.05 0.744 chaperone CHARACTERIZ function ED prediction EcolC_1680 b1963 yedR inner membrane protein - -l -0.01 -0.05 0.04 0.00 0.690 EcolC_1681 b1962 yedJ predicted hydrolase, HD superfamily POORLY General 0.14 0.11 -0.14 -0.17 0.716 CHARACTERIZ function ED prediction l EcolC_1682 b1961 dcm DNA methyltransferase INFORMATION Replication, 0.35 0.53 0.23 0.40 0.625 STORAGE AND recombination PROCESSING and repair EcolC_1683 b1960 vsr DNA mismatch endonuclease of very short INFORMATION Replication, 0.18 0.02 -0.05 -0.20 0.543 patch repair STORAGE AND recombination PROCESSING and repair EcolC_1685 b1958 yedI conserved inner membrane protein POORLY Function -0.07 0.08 0.12 0.27 0.312 CHARACTERIZ unknown ED EcolC_1686 b1957 yodC predicted protein POORLY Function -0.32 -0.27 0.03 0.08 0.616 CHARACTERIZ unknown ED EcolC_1687 b1956 yedQ predicted membrane-anchored diguanylate CELLULAR Signal 0.38 0.03 0.47 0.12 0.321 cyclase PROCESSES transduction AND mechanisms SIGNALING EcolC_1688 b1955 yedP predicted mannosyl-3-phosphoglycerate POORLY General -0.09 0.01 0.09 0.19 0.119 phosphatase CHARACTERIZ function ED prediction EcolC_1689 b1953 yodD predicted protein - -l -0.19 -0.34 0.60 0.46 0.162 EcolC_1690 b1952 dsrB predicted protein - - 0.12 0.30 0.21 0.39 0.413 EcolC_1691 b1951 rcsA DNA-binding transcriptional activator, co- CELLULAR Signal -0.03 -0.12 -0.15 -0.24 0.353 regulator with RcsB PROCESSES transduction AND mechanisms SIGNALING EcolC_1692 b1950 fliR flagellar export pore protein CELLULAR Cell motility 0.04 0.04 -0.11 -0.11 0.982 PROCESSES AND SIGNALING EcolC_1693 b1949 fliQ flagellar biosynthesis protein CELLULAR Cell motility -0.02 -0.16 -0.01 -0.15 0.117 PROCESSES AND SIGNALING EcolC_1694 b1948 fliP flagellar biosynthesis protein CELLULAR Cell motility -0.11 -0.06 -0.06 -0.01 0.911 PROCESSES AND SIGNALING EcolC_1696 b1946 fliN flagellar motor switching and energizing CELLULAR Cell motility -0.12 0.11 -0.01 0.22 0.185 component PROCESSES AND SIGNALING EcolC_1697 b1945 fliM flagellar motor switching and energizing CELLULAR Cell motility 0.01 -0.24 -0.17 -0.41 0.279 component PROCESSES AND SIGNALING EcolC_1698 b1944 fliL flagellar biosynthesis protein CELLULAR Cell motility -0.11 0.12 0.05 0.27 0.245 PROCESSES AND SIGNALING EcolC_1700 b1942 fliJ flagellar protein CELLULAR Cell motility 0.06 0.04 0.04 0.03 0.711 PROCESSES AND SIGNALING EcolC_1701 b1941 fliI flagellum-specific ATP synthase CELLULAR Cell motility 0.15 0.18 0.13 0.16 0.796 PROCESSES AND SIGNALING EcolC_1702 b1940 fliH negative regulator of FliI ATPase activity CELLULAR Cell motility 0.10 0.14 0.01 0.05 0.841 PROCESSES AND SIGNALING EcolC_1703 b1939 fliG flagellar motor switching and energizing CELLULAR Cell motility 0.03 -0.03 0.07 0.01 0.733 component PROCESSES AND SIGNALING EcolC_1704 b1938 fliF flagellar basal-body MS-ring and collar CELLULAR Cell motility 0.03 0.08 0.09 0.14 0.813 protein PROCESSES AND SIGNALING EcolC_1705 b1937 fliE flagellar basal-body component CELLULAR Cell motility -0.12 0.04 0.01 0.18 0.074 PROCESSES AND SIGNALING EcolC_1705 b1936 intG - - - 0.36 0.22 0.08 -0.06 0.716 EcolC_1708 b1931 yedK predicted protein POORLY Function 0.12 0.18 0.16 0.22 0.974 CHARACTERIZ unknown ED EcolC_1709 b1930 yedF conserved protein, UPF0033 family CELLULAR Posttranslatio -0.13 -0.03 0.07 0.17 0.991 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1710 b1929 yedE predicted inner membrane protein POORLY General 0.32 0.27 0.27 0.21 0.830 CHARACTERIZ function ED prediction EcolC_1711 b1928 yedD lipoprotein - -l -0.22 0.01 0.03 0.26 0.090 EcolC_1712 b1927 amyA cytoplasmic alpha-amylase METABOLISM Carbohydrate -0.05 0.05 0.24 0.33 0.963 transport and metabolism EcolC_1713 b1926 fliT predicted chaperone - - 0.14 -0.07 0.09 -0.12 0.191 EcolC_1714 b1925 fliS flagellar protein potentiates polymerization CELLULAR Cell motility 0.16 -0.01 0.12 -0.05 0.595 PROCESSES AND SIGNALING EcolC_1715 b1924 fliD flagellar filament capping protein CELLULAR Cell motility -0.01 0.13 0.02 0.15 0.336 PROCESSES AND SIGNALING EcolC_1717 b1922 fliA RNA polymerase, sigma 28 (sigma F) INFORMATION Transcription -0.16 0.11 0.06 0.33 0.076 factor STORAGE AND PROCESSING EcolC_1718 b1921 fliZ RpoS antagonist; putative regulator of FliA - - -0.03 0.21 0.22 0.46 0.241 activity EcolC_1719 b1920 fliY cystine transporter subunit METABOLISM Amino acid -0.70 -0.37 -0.09 0.24 0.079 transport and metabolism EcolC_1720 b1919 dcyD D-cysteine desulfhydrase, PLP-dependent METABOLISM Amino acid 0.34 0.71 0.19 0.57 0.038 transport and metabolism EcolC_1721 b1918 yecS inner membrane protein, predicted METABOLISM Amino acid 0.38 0.35 0.37 0.33 0.903 transporter subunit: membrane component transport and of ABC superfamily metabolism EcolC_1722 b1917 yecC predicted transporter subunit: ATP-binding METABOLISM Amino acid 0.49 0.39 0.31 0.22 0.690 component of ABC superfamily transport and metabolism EcolC_1724 b1915 yecF conserved protein, DUF2594 family - - 0.11 0.13 0.30 0.31 0.444 EcolC_1725 b1914 uvrY DNA-binding response regulator in two- CELLULAR Signal 0.33 0.52 0.09 0.29 0.327 component regulatory system with BarA PROCESSES transduction AND mechanisms SIGNALING EcolC_1726 b1913 uvrC excinuclease UvrABC, endonuclease INFORMATION Replication, 0.42 0.06 -0.29 -0.65 0.104 subunit STORAGE AND recombination PROCESSING and repair EcolC_1727 b1912 pgsA phosphatidylglycerophosphate synthetase METABOLISM Lipid 0.44 0.70 0.09 0.35 0.810 transport and metabolism EcolC_1728 b1908 yecA conserved protein, UPF0149 family POORLY General -0.36 -0.20 -0.06 0.11 0.625 CHARACTERIZ function ED prediction EcolC_1729 b1907 tyrP tyrosine transporter METABOLISM Aminol acid -0.01 -0.12 0.05 -0.06 0.736 transport and metabolism EcolC_1730 b1906 yecH DUF2492 family protein, function - - -0.01 0.04 0.35 0.39 0.976 EcolC_1731 b1905 ftnA ferritin iron storage protein (cytoplasmic) METABOLISM Inorganic ion -0.71 -1.45 -0.19 -0.93 0.041 transport and metabolism EcolC_1732 b1904 yecR lipoprotein, function unknown - - -0.04 -0.08 0.20 0.15 0.334 EcolC_1733 b1902 ftnB ferritin B, probable ferrous iron reservoir METABOLISM Inorganic ion 0.11 0.57 0.27 0.73 0.272 transport and metabolism EcolC_1734 b1901 araF L-arabinose transporter subunit METABOLISM Carbohydrate 0.04 0.04 -0.18 -0.18 0.902 transport and metabolism EcolC_1735 b1900 araG fused L-arabinose transporter subunits of METABOLISM Carbohydrate 0.19 0.38 0.05 0.23 0.923 ABC superfamily: ATP-binding transport and components metabolism EcolC_1736 b4460 araH fused L-arabinose transporter subunits of METABOLISM Carbohydrate 0.08 0.03 0.09 0.03 0.796 ABC superfamily: membrane components transport and metabolism EcolC_1737 b1897 otsB trehalose-6-phosphate phosphatase, METABOLISM Carbohydrate 0.14 -0.13 0.09 -0.17 0.186 biosynthetic transport and metabolism EcolC_1738 b1896 otsA trehalose-6-phosphate synthase METABOLISM Carbohydrate 0.06 0.05 0.04 0.04 0.728 transport and metabolism EcolC_1739 b1895 uspC universal stress protein CELLULAR Signal -0.11 0.00 0.18 0.29 0.838 PROCESSES transduction AND mechanisms SIGNALING EcolC_1740 b1892 flhD DNA-binding transcriptional dual regulator - - -0.14 -0.21 -0.16 -0.23 0.884 with FlhC EcolC_1741 b1891 flhC DNA-binding transcriptional dual regulator - - -0.07 0.03 0.18 0.29 0.378 with FlhD EcolC_1742 b1890 motA proton conductor component of flagella CELLULAR Cell motility -0.22 -0.19 -0.24 -0.21 0.781 motor PROCESSES AND SIGNALING EcolC_1743 b1889 motB protein that enables flagellar motor rotation CELLULAR Cell motility -0.05 -0.08 -0.04 -0.07 0.826 PROCESSES AND SIGNALING EcolC_1744 b1888 cheA fused chemotactic sensory histidine kinase CELLULAR Cell motility 0.01 -0.02 -0.13 -0.16 0.960 in two-component regulatory system with PROCESSES CheB and CheY: sensory histidine AND kinase/signal sensing protein SIGNALING EcolC_1745 b1887 cheW purine-binding chemotaxis protein CELLULAR Cell motility 0.15 0.32 0.29 0.46 0.045 PROCESSES AND SIGNALING EcolC_1746 b1886 tar methyl-accepting chemotaxis protein II CELLULAR Cell motility 0.06 -0.03 -0.02 -0.11 0.318 PROCESSES AND SIGNALING EcolC_1747 b1885 tap methyl-accepting protein IV CELLULAR Cell motility -0.04 -0.08 -0.01 -0.05 0.427 PROCESSES AND SIGNALING EcolC_1748 b1884 cheR chemotaxis regulator, protein-glutamate CELLULAR Cell motility 0.00 -0.30 -0.08 -0.39 0.340 methyltransferase PROCESSES AND SIGNALING EcolC_1749 b1883 cheB fused chemotaxis regulator: protein- CELLULAR Cell motility 0.04 -0.01 -0.06 -0.11 0.552 glutamate methylesterase in two- PROCESSES component regulatory system with CheA AND SIGNALING EcolC_1750 b1882 cheY chemotaxis regulator transmitting signal to CELLULAR Signal 0.04 0.08 0.12 0.16 0.842 flagellar motor component PROCESSES transduction AND mechanisms SIGNALING EcolC_1751 b1881 cheZ chemotaxis regulator, CELLULAR Cell motility 0.02 0.09 0.18 0.25 0.985 for CheY PROCESSES AND SIGNALING EcolC_1752 b1880 flhB flagellin export apparatus, substrate CELLULAR Cell motility -0.12 -0.17 0.00 -0.06 0.116 specificity protein PROCESSES AND SIGNALING EcolC_1753 b1879 flhA predicted flagellar export pore protein CELLULAR Cell motility -0.13 -0.08 0.02 0.06 0.990 PROCESSES AND SIGNALING EcolC_1754 b1878 flhE proton seal during flagellar secretion - - -0.12 0.03 -0.15 0.00 0.283 EcolC_1756 b1876 argS arginyl-tRNA synthetase INFORMATION Translation, 0.19 0.47 0.15 0.43 0.145 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1757 b1875 yecM predicted metal-binding enzyme POORLY Function -0.11 -0.01 0.06 0.15 0.795 CHARACTERIZ unknown ED EcolC_1758 b1874 cutC copper homeostasis protein METABOLISM Inorganic ion -0.27 -0.21 -0.25 -0.19 0.835 transport and metabolism EcolC_1759 b1873 torY TMAO reductase III (TorYZ), cytochrome METABOLISM Energy 0.16 0.11 0.21 0.15 0.748 c-type subunit production and conversion EcolC_1760 b1872 torZ trimethylamine N-oxide reductase system METABOLISM Energy 0.28 0.36 0.37 0.46 0.670 III, catalytic subunit production and conversion EcolC_1761 b1871 cmoB tRNA (cmo5U34)- METABOLISM Coenzyme 0.63 0.62 0.36 0.35 0.852 carboxymethyltransferase, carboxy-SAM- transport and dependent metabolism EcolC_1762 b1870 cmoA carboxy-SAM synthase METABOLISM Coenzyme 0.04 0.41 0.12 0.49 0.126 transport and metabolism EcolC_1763 b1869 yecN inner membrane protein, MAPEG family POORLY General 0.16 0.65 0.01 0.50 0.020 CHARACTERIZ function ED prediction EcolC_1764 b1868 yecE conserved protein, UPF0759 family POORLY Functionl 0.23 0.49 0.05 0.31 0.224 CHARACTERIZ unknown ED EcolC_1765 b1867 yecD isochorismatase family protein METABOLISM Secondary 1.16 1.07 0.17 0.07 0.576 metabolites biosynthesis, transport and catabolism EcolC_1767 b1865 nudB dihydroneopterin triphosphate INFORMATION Replication, -0.53 -0.54 -0.26 -0.27 0.804 pyrophosphatase STORAGE AND recombination PROCESSING and repair EcolC_1768 b1864 yebC conserved protein, UPF0082 family POORLY Function 0.06 0.36 0.33 0.62 0.180 CHARACTERIZ unknown ED EcolC_1769 b1863 ruvC component of RuvABC resolvasome, INFORMATION Replication, -0.39 -0.08 -0.06 0.25 0.002 endonuclease STORAGE AND recombination PROCESSING and repair EcolC_1770 b1862 yebB conserved protein, DUF830 family - - 0.16 0.10 0.00 -0.07 0.947 EcolC_1771 b1861 ruvA component of RuvABC resolvasome, INFORMATION Replication, 0.75 0.48 -0.21 -0.49 0.467 regulatory subunit STORAGE AND recombination PROCESSING and repair EcolC_1772 b1860 ruvB ATP-dependent DNA helicase, component INFORMATION Replication, 0.54 0.81 0.32 0.59 0.191 of RuvABC resolvasome STORAGE AND recombination PROCESSING and repair EcolC_1773 b1859 znuB zinc transporter subunit: membrane METABOLISM Inorganic ion 0.29 0.61 0.45 0.76 0.100 component of ABC superfamily transport and metabolism EcolC_1774 b1858 znuC zinc transporter subunit: ATP-binding METABOLISM Inorganic ion 0.22 0.06 0.06 -0.10 0.809 component of ABC superfamily transport and metabolism EcolC_1775 b1857 znuA zinc transporter subunit: periplasmic- METABOLISM Inorganic ion 0.63 0.38 0.20 -0.06 0.201 binding component of ABC superfamily transport and metabolism EcolC_1776 b1856 mepM murein DD-endopeptidase, space-maker CELLULAR Cell 0.68 0.53 0.15 0.00 0.382 hydrolase, septation protein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1777 b1855 waaN myristoyl-acyl carrier protein (ACP)- CELLULAR Cell 0.29 0.41 0.11 0.23 0.315 dependent acyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1778 b1854 pykA II METABOLISM Carbohydrate 0.16 -0.06 -0.13 -0.34 0.258 transport and metabolism EcolC_1779 b1853 yebK predicted DNA-binding transcriptional INFORMATION Transcription 0.77 0.26 0.15 -0.35 0.092 regulator STORAGE AND PROCESSING EcolC_1780 b1852 zwf glucose-6-phosphate 1-dehydrogenase METABOLISM Carbohydrate -0.03 -0.05 -0.18 -0.20 0.601 transport and metabolism EcolC_1781 b1851 edd 6-phosphogluconate dehydratase METABOLISM Amino acid 0.15 0.38 0.29 0.52 0.123 transport and metabolism EcolC_1782 b1850 eda multifunctional 2-keto-3-deoxygluconate 6- METABOLISM Carbohydrate -0.07 0.23 0.17 0.48 0.255 phosphate aldolase and 2-keto-4- transport and hydroxyglutarate aldolase and oxaloacetate metabolism decarboxylase EcolC_1783 b1849 purT phosphoribosylglycinamide METABOLISM Nucleotide 0.00 -0.04 0.07 0.04 0.808 formyltransferase 2 transport and metabolism EcolC_1784 b1848 yebG conserved protein regulated by LexA POORLY Function 0.01 0.23 0.12 0.34 0.650 CHARACTERIZ unknown ED EcolC_1785 b1847 yebF extracellular Colicin M immunity family - - 0.14 0.32 0.05 0.23 0.423 protein EcolC_1786 b1846 yebE inner membrane protein, DUF533 family POORLY Function 0.56 0.11 0.26 -0.19 0.022 CHARACTERIZ unknown ED EcolC_1787 b1845 ptrB protease II METABOLISM Amino acid 0.13 0.18 -0.06 -0.01 0.718 transport and metabolism EcolC_1788 b1844 exoX 10; DNA INFORMATION Replication, 0.30 0.10 0.33 0.12 0.394 exonuclease X STORAGE AND recombination PROCESSING and repair EcolC_1789 b1843 yobB conserved protein POORLY General 0.29 0.09 -0.05 -0.25 0.606 CHARACTERIZ function ED prediction EcolC_1790 b1842 holE DNA polymerase III, theta subunit - -l -0.27 -1.13 0.25 -0.61 0.002 EcolC_1791 b1841 yobA conserved protein POORLY General 0.31 -0.12 0.08 -0.35 0.021 CHARACTERIZ function ED prediction EcolC_1792 b1840 yebZ inner membrane protein METABOLISM Inorganicl ion 0.90 0.03 -0.01 -0.88 0.006 transport and metabolism EcolC_1793 b1839 yebY predicted protein - - 0.50 0.56 0.41 0.48 0.985 EcolC_1794 b1838 pphA serine/threonine-specific protein CELLULAR Signal 0.01 -0.02 0.49 0.46 0.932 phosphatase 1 PROCESSES transduction AND mechanisms SIGNALING EcolC_1795 b1837 yebW predicted protein - - 0.04 0.16 0.42 0.54 0.980 EcolC_1796 b1836 yebV predicted protein - - 0.01 0.24 0.15 0.38 0.528 EcolC_1798 b1834 yebT conserved protein POORLY General 0.58 0.32 0.13 -0.13 0.177 CHARACTERIZ function ED prediction EcolC_1799 b1833 yebS inner membrane protein POORLY Functionl 0.91 0.15 0.05 -0.71 0.005 CHARACTERIZ unknown ED EcolC_1800 b1832 msrC free methionine-(R)-sulfoxide reductase CELLULAR Signal -0.06 -0.06 0.04 0.05 0.953 PROCESSES transduction AND mechanisms SIGNALING EcolC_1801 b1831 proQ RNA chaperone, probable regulator of CELLULAR Signal 0.46 -0.15 -0.27 -0.88 0.019 ProP translation PROCESSES transduction AND mechanisms SIGNALING EcolC_1802 b1830 prc carboxy-terminal protease for penicillin- CELLULAR Cell -0.05 -0.25 -0.30 -0.49 0.247 binding protein 3 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1803 b1829 htpX predicted endopeptidase CELLULAR Posttranslatio 0.85 -0.25 -0.22 -1.32 0.005 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1804 b1828 yebQ predicted transporter METABOLISM Carbohydrate -0.16 -0.20 -0.17 -0.21 0.530 transport and metabolism EcolC_1805 b1827 kdgR DNA-binding transcriptional regulator f INFORMATION Transcription 1.46 1.11 0.01 -0.34 0.282 kdgK, kdgT, eda STORAGE AND PROCESSING EcolC_1806 b4536 yobH predicted protein - - 0.06 -0.04 0.08 -0.02 0.425 EcolC_1807 b1826 mgrB regulatory peptide for PhoPQ, feedback - - 0.73 -0.02 0.45 -0.30 0.004 inhibition EcolC_1808 b1825 yebO predicted inner membrane protein - - 0.89 -0.11 0.47 -0.53 0.033 EcolC_1809 b1823 cspC stress protein, member of the CspA-family INFORMATION Transcription 0.67 0.23 -0.04 -0.47 0.036 STORAGE AND PROCESSING EcolC_1810 b1822 rlmA 23S rRNA m(1)G745 methyltransferase, METABOLISM Coenzyme 0.22 0.29 0.11 0.18 0.718 SAM-dependent transport and metabolism EcolC_1811 b1821 mntP probable Mn(2+) efflux pump, mntR- POORLY Function 0.04 0.22 0.07 0.25 0.225 regulated CHARACTERIZ unknown ED EcolC_1812 b1820 yobD inner membrane protein, UPF0266 family POORLY Function -0.12 -0.19 -0.22 -0.30 0.962 CHARACTERIZ unknown ED EcolC_1813 b1819 manZ mannose-specific enzyme IID component METABOLISM Carbohydrate 0.11 0.78 -0.06 0.61 0.010 of PTS transport and metabolism EcolC_1814 b1818 manY mannose-specific enzyme IIC component METABOLISM Carbohydrate -0.07 0.73 0.06 0.87 0.032 of PTS transport and metabolism EcolC_1817 b1816 yoaE fused predicted membrane METABOLISM Inorganic ion 0.30 0.42 0.27 0.39 0.379 protein/conserved protein transport and metabolism EcolC_1818 b1815 yoaD predicted membrane-anchored cyclic-di- CELLULAR Signal -0.01 0.09 -0.02 0.08 0.429 GMP phosphodiesterase, regulator of PROCESSES transduction cellulose production AND mechanisms SIGNALING EcolC_1819 b1814 sdaA L-serine deaminase I METABOLISM Amino acid 0.10 0.53 0.03 0.46 0.023 transport and metabolism EcolC_1820 b1813 nudL predicted NUDIX hydrolase - - 0.20 0.29 0.09 0.18 0.592 EcolC_1821 b1812 pabB aminodeoxychorismate synthase, subunit I METABOLISM Amino acid 0.16 0.19 0.03 0.06 0.926 transport and metabolism EcolC_1822 b1811 yoaH conserved protein POORLY Function 0.30 0.56 0.33 0.58 0.118 CHARACTERIZ unknown ED EcolC_1824 b1809 yoaB putative reactive intermediate deaminase INFORMATION Translation, -0.03 -0.04 -0.04 -0.05 0.424 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1825 b1808 yoaA conserved protein with nucleoside INFORMATION Transcription 0.27 0.35 0.12 0.20 0.786 triphosphate hydrolase domain STORAGE AND PROCESSING EcolC_1826 b1807 tsaB tRNA(ANN) t(6)A37 CELLULAR Posttranslatio -0.09 -0.04 0.10 0.15 0.842 threonylcarbamoyladenosine modification PROCESSES nal protein; binding partner and protease for AND modification, TsaD SIGNALING protein turnover, chaperones EcolC_1827 b1806 yeaY lipoprotein, RpoE-regulated, fucntion CELLULAR Cell 0.01 0.04 0.39 0.43 0.829 unknown PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1828 b1805 fadD acyl-CoA synthetase (long-chain-fatty- METABOLISM Lipid 0.47 -0.05 0.08 -0.44 0.047 acid--CoA ligase) transport and metabolism EcolC_1829 b1804 rnd ribonuclease D INFORMATION Translation, 0.15 0.22 0.07 0.14 0.718 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1830 b1803 yeaX predicted oxidoreductase METABOLISM Energy 0.07 -0.06 -0.01 -0.13 0.600 production and conversion EcolC_1831 b1802 yeaW predicted 2Fe-2S cluster-containing protein METABOLISM Inorganic ion -0.16 0.06 0.12 0.34 0.230 transport and metabolism EcolC_1832 b1801 yeaV predicted transporter CELLULAR Cell -0.07 0.05 -0.06 0.05 0.547 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1833 b1800 dmlA D-malate oxidase, NAD-dependent; METABOLISM Energy -0.66 -1.48 0.91 0.10 0.080 probable tartrate dehydrogenase production and conversion EcolC_1834 b1799 dmlR DNA-binding transcriptional activator for INFORMATION Transcription 0.12 0.03 -0.07 -0.15 0.768 dmlA STORAGE AND PROCESSING EcolC_1835 b1798 leuE neutral amino-acid efflux system METABOLISM Amino acid 0.13 0.11 0.11 0.08 0.922 transport and metabolism EcolC_1836 b1797 yeaR conserved protein METABOLISM Inorganic ion -0.20 -0.18 -0.21 -0.19 0.600 transport and metabolism EcolC_1837 b1796 yoaG predicted protein - - -0.11 0.01 0.09 0.21 0.746 EcolC_1838 b1795 yeaQ conserved protein, UPF0410 family POORLY Function -0.40 -0.85 0.27 -0.19 0.068 CHARACTERIZ unknown ED EcolC_1839 b1794 yeaP diguanylate cyclase CELLULAR Signal 0.20 0.47 0.11 0.38 0.047 PROCESSES transduction AND mechanisms SIGNALING EcolC_1841 b1792 yeaO conserved protein POORLY Function -0.16 0.13 -0.09 0.20 0.080 CHARACTERIZ unknown ED EcolC_1842 b1791 yeaN predicted transporter METABOLISM Inorganic ion 0.18 0.35 0.11 0.28 0.179 transport and metabolism EcolC_1843 b1790 yeaM predicted DNA-binding transcriptional INFORMATION Transcription 0.10 0.08 0.14 0.13 0.716 regulator STORAGE AND PROCESSING EcolC_1844 b1789 yeaL predicted inner membrane protein, POORLY Function 0.02 0.20 0.16 0.35 0.198 UPF0756 family CHARACTERIZ unknown ED EcolC_1845 b1787 yeaK conserved protein POORLY Function 0.12 0.23 0.07 0.18 0.381 CHARACTERIZ unknown ED EcolC_1846 b1786 yeaJ predicted diguanylate cyclase CELLULAR Signal 0.03 0.02 0.12 0.11 0.816 PROCESSES transduction AND mechanisms SIGNALING EcolC_1847 b1785 yeaI predicted membrane-anchored diguanylate CELLULAR Signal 0.03 -0.17 0.11 -0.09 0.417 cyclase PROCESSES transduction AND mechanisms SIGNALING EcolC_1848 b1784 yeaH UPF0229 family protein POORLY Function -1.78 -2.00 0.39 0.17 0.390 CHARACTERIZ unknown ED EcolC_1849 b1783 yeaG protein kinase, function unknown; CELLULAR Signal -1.97 -2.35 0.29 -0.08 0.252 autokinase PROCESSES transduction AND mechanisms SIGNALING EcolC_1850 b1782 mipA scaffolding protein for murein synthesizing CELLULAR Cell -0.39 -0.08 -0.14 0.16 0.063 machinery PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1851 b1781 yeaE aldo-keto reductase, methylglyoxal to POORLY General -0.32 0.09 -0.10 0.31 0.175 acetol, NADPH-dependent CHARACTERIZ function ED prediction l EcolC_1852 b1780 yeaD conserved protein METABOLISM Carbohydrate 0.24 1.28 0.01 1.05 0.004 transport and metabolism EcolC_1853 b1779 gapA glyceraldehyde-3-phosphate dehydrogenase METABOLISM Carbohydrate 0.31 0.99 -0.03 0.65 0.008 A transport and metabolism EcolC_1854 b1778 msrB methionine sulfoxide reductase B CELLULAR Posttranslatio 0.16 -1.02 0.29 -0.89 0.013 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1855 b1777 yeaC conserved protein POORLY Function 0.45 -0.09 0.34 -0.19 0.727 CHARACTERIZ unknown ED EcolC_1856 b1776 ydjL predicted oxidoreductase, Zn-dependent METABOLISM Amino acid 0.27 0.11 0.10 -0.06 0.252 and NAD(P)-binding transport and metabolism EcolC_1858 b1774 ydjJ predicted oxidoreductase, Zn-dependent METABOLISM Amino acid 0.37 0.01 0.23 -0.12 0.089 and NAD(P)-binding transport and metabolism EcolC_1859 b1773 ydjI predicted aldolase METABOLISM Carbohydrate 0.18 0.07 0.04 -0.07 0.479 transport and metabolism EcolC_1860 b1772 ydjH predicted kinase METABOLISM Carbohydrate 0.25 0.05 0.22 0.02 0.169 transport and metabolism EcolC_1862 b1770 ydjF predicted DNA-binding transcriptional INFORMATION Transcription 0.71 0.26 0.01 -0.43 0.018 regulator STORAGE AND PROCESSING EcolC_1863 b1769 ydjE predicted transporter METABOLISM Carbohydrate -0.02 -0.10 -0.17 -0.25 0.810 transport and metabolism EcolC_1864 b1768 pncA nicotinamidase/pyrazinamidase METABOLISM Secondary 0.43 0.91 0.35 0.82 0.090 metabolites biosynthesis, transport and catabolism EcolC_1865 b1767 ansA cytoplasmic L-asparaginase I METABOLISM Amino acid 0.19 0.11 0.12 0.04 0.637 transport and metabolism EcolC_1866 b1766 sppA protease IV (signal peptide peptidase) CELLULAR Posttranslatio 0.46 0.27 0.26 0.07 0.220 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1867 b1765 ydjA predicted oxidoreductase METABOLISM Energy 0.09 -0.79 0.13 -0.75 0.005 production and conversion EcolC_1868 b1764 selD selenophosphate synthase METABOLISM Amino acid 0.30 0.17 -0.05 -0.18 0.801 transport and metabolism EcolC_1869 b1763 topB DNA topoisomerase III INFORMATION Replication, 0.75 0.57 0.02 -0.16 0.173 STORAGE AND recombination PROCESSING and repair EcolC_1870 b1762 ynjI inner membrane protein - - -0.04 -0.12 -0.07 -0.16 0.201 EcolC_1871 b1761 gdhA glutamate dehydrogenase, NADP-specific METABOLISM Amino acid -0.19 -0.13 -0.32 -0.26 0.458 transport and metabolism EcolC_1872 b1760 ynjH conserved protein, DUF1496 family - - 0.25 0.12 0.14 0.01 0.592 EcolC_1873 b1759 nudG CTP pyrophosphohydrolase; also METABOLISM Nucleotide 0.28 0.39 0.23 0.34 0.751 hydrolyzes 2-hydroxy-dATP, 8-hydroxy- transport and dGTP, 5-hydroxy-CTP, dCTP and 5- metabolism methyl-dCTP EcolC_1874 b1758 ynjF inner membrane protein, METABOLISM Lipid 0.24 0.50 0.27 0.54 0.961 phosphatidylglycerophosphate synthase transport and homolog metabolism EcolC_1875 b1757 ynjE IscS specificity factor for molybdenum METABOLISM Inorganic ion 0.08 -0.01 0.06 -0.04 0.288 cofactor biosynthesis; probable alternate transport and MoaD transpersulfidase; weak metabolism thiosulfate:cyanide sulfurtransferase; rhodanese-like protein EcolC_1876 b1756 ynjD predicted transporter subunit: ATP-binding POORLY General -0.06 -0.04 -0.01 0.01 0.668 component of ABC superfamily CHARACTERIZ function ED prediction EcolC_1877 b1755 ynjC predicted inner membrane ABC transporter POORLY Generall -0.12 -0.14 0.00 -0.03 0.926 permease, function unknown CHARACTERIZ function ED prediction EcolC_1878 b1754 ynjB conserved protein POORLY Generall 0.03 -0.03 0.03 -0.03 0.838 CHARACTERIZ function ED prediction EcolC_1879 b1753 ynjA conserved protein POORLY Functionl 0.03 0.12 -0.07 0.01 0.507 CHARACTERIZ unknown ED EcolC_1880 b1752 ydjZ Inner membrane protein, TVP38/TMEM64 POORLY Function -0.36 -0.34 -0.27 -0.25 0.931 family CHARACTERIZ unknown ED EcolC_1881 b1751 ydjY predicted protein - - -0.05 -0.01 -0.07 -0.03 0.753 EcolC_1882 b1750 ydjX inner membrane protein, TVP38/TMEM64 POORLY Function 0.25 0.44 0.01 0.20 0.899 family CHARACTERIZ unknown ED EcolC_1883 b1749 xthA exonuclease III INFORMATION Replication, 0.11 0.11 -0.02 -0.02 0.713 STORAGE AND recombination PROCESSING and repair EcolC_1884 b1748 astC succinylornithine transaminase, PLP- METABOLISM Amino acid 0.72 -0.20 0.00 -0.91 0.001 dependent transport and metabolism EcolC_1885 b1747 astA arginine succinyltransferase METABOLISM Amino acid 0.15 -0.20 -0.01 -0.36 0.112 transport and metabolism EcolC_1886 b1746 astD succinylglutamic semialdehyde METABOLISM Energy 0.82 0.15 0.23 -0.44 0.184 dehydrogenase production and conversion EcolC_1887 b1745 astB succinylarginine dihydrolase METABOLISM Amino acid 0.10 -0.02 -0.10 -0.22 0.629 transport and metabolism EcolC_1889 b1743 spy periplasmic ATP-independent protein CELLULAR Intracellular 2.40 0.99 0.27 -1.15 0.018 refolding chaperone, stress-induced PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_1891 b1741 cho endonuclease of nucleotide excision repair INFORMATION Replication, 0.12 0.04 -0.03 -0.11 0.718 STORAGE AND recombination PROCESSING and repair EcolC_1892 b1740 nadE NAD synthetase, NH3/glutamine- METABOLISM Coenzyme -0.47 -0.20 0.05 0.31 0.097 dependent transport and metabolism EcolC_1893 b1739 osmE DNA-binding transcriptional activator INFORMATION Translation, -1.50 -1.31 -0.22 -0.02 0.284 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1894 b1738 chbB N,N'-diacetylchitobiose-specific enzyme METABOLISM Carbohydrate 0.12 0.05 0.04 -0.03 0.737 IIB component of PTS transport and metabolism EcolC_1895 b1737 chbC N,N'-diacetylchitobiose-specific enzyme METABOLISM Carbohydrate 0.07 -0.10 -0.11 -0.28 0.204 IIC component of PTS transport and metabolism EcolC_1896 b1736 chbA N,N'-diacetylchitobiose-specific enzyme METABOLISM Carbohydrate 0.49 0.33 0.21 0.05 0.322 IIA component of PTS transport and metabolism EcolC_1897 b1735 chbR repressor of chb operon for N,N'- INFORMATION Transcription -0.03 0.00 -0.04 -0.01 0.882 diacetylchitobiose utilization STORAGE AND PROCESSING EcolC_1898 b1734 chbF phospho-chitobiase; general 6-phospho- METABOLISM Carbohydrate -0.04 -0.02 -0.09 -0.07 0.685 beta-glucosidase activity transport and metabolism EcolC_1899 b1733 chbG chito-oligosaccharide deacetylase POORLY Function 0.15 0.12 0.34 0.31 0.874 CHARACTERIZ unknown ED EcolC_1900 b1732 katE catalase HPII, heme d-containing METABOLISM Inorganic ion -0.13 -0.19 0.06 -0.01 0.838 transport and metabolism EcolC_1901 b1731 cedA cell division modulator - - 0.13 0.29 0.09 0.25 0.371 EcolC_1902 b1730 ydjO predicted protein - - -0.07 -0.26 -0.07 -0.26 0.565 EcolC_1903 b1729 ydjN predicted transporter POORLY General -0.26 -0.24 -0.10 -0.08 0.952 CHARACTERIZ function ED prediction EcolC_1904 b1728 ydjM inner membrane protein regulated by LexA POORLY Generall -0.01 -0.01 0.00 0.00 0.722 CHARACTERIZ function ED prediction EcolC_1905 b1727 yniC 2-deoxyglucose-6-P phosphatase POORLY Generall -0.14 0.12 -0.06 0.21 0.721 CHARACTERIZ function ED prediction l EcolC_1906 b1726 yniB predicted inner membrane protein - - -0.14 -0.17 -0.09 -0.12 0.902 EcolC_1907 b1725 yniA predicted phosphotransferase/kinase METABOLISM Carbohydrate 0.10 0.36 0.08 0.35 0.380 transport and metabolism EcolC_1908 b1724 ydiZ predicted protein - - -0.36 -0.17 0.09 0.28 0.028 EcolC_1909 b1723 pfkB 6- II METABOLISM Carbohydrate 0.04 -0.33 0.22 -0.15 0.030 transport and metabolism EcolC_1910 b1722 ydiY predicted outer membrane protein, acid- CELLULAR Cell 0.02 0.05 -0.03 0.00 0.312 inducible PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1913 b1719 thrS threonyl-tRNA synthetase INFORMATION Translation, -0.44 0.36 -0.06 0.75 0.021 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1914 b1718 infC protein chain initiation factor IF-3 INFORMATION Translation, -0.86 -0.26 -0.01 0.59 0.093 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1915 b1717 rpmI 50S ribosomal subunit protein L35 INFORMATION Translation, -0.44 0.08 0.00 0.53 0.040 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1916 b1716 rplT 50S ribosomal subunit protein L20 INFORMATION Translation, 0.23 0.42 0.32 0.52 0.486 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1917 b1714 pheS tRNA synthetase, alpha INFORMATION Translation, 0.02 0.35 -0.42 -0.09 0.092 subunit STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1918 b1713 pheT phenylalanine tRNA synthetase, beta INFORMATION Translation, -0.26 0.08 -0.16 0.17 0.034 subunit STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1919 b1712 ihfA integration host factor (IHF), DNA-binding INFORMATION Replication, -0.63 -0.56 0.20 0.27 0.986 protein, alpha subunit STORAGE AND recombination PROCESSING and repair EcolC_1920 b1711 btuC vitamin B12 transporter subunit: membrane METABOLISM Coenzyme -0.10 0.11 -0.10 0.12 0.740 component of ABC superfamily transport and metabolism EcolC_1921 b1710 btuE glutathione peroxidase CELLULAR Posttranslatio 0.05 0.40 0.02 0.37 0.213 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1922 b1709 btuD vitamin B12 transporter subunit : ATP- METABOLISM Coenzyme 0.20 0.27 0.10 0.17 0.815 binding component of ABC superfamily transport and metabolism EcolC_1923 b1708 nlpC predicted peptidase, C40 clan, lipoprotein CELLULAR Cell 0.01 0.16 0.25 0.40 0.282 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1924 b1707 ydiV anti-FlhD4C2 factor, inactive EAL family CELLULAR Signal 0.17 0.21 0.10 0.14 0.443 phosphodiesterase PROCESSES transduction AND mechanisms SIGNALING EcolC_1925 b1706 ydiU conserved protein, UPF0061 family POORLY Function 0.51 0.41 0.18 0.09 0.897 CHARACTERIZ unknown ED EcolC_1927 b1704 aroH 3-deoxy-D-arabino-heptulosonate-7- METABOLISM Amino acid 0.09 0.27 0.24 0.43 0.766 phosphate synthase, tryptophan repressible transport and metabolism EcolC_1928 b1703 ppsR bifunctional regulatory protein: PEP POORLY Function -0.20 -0.22 -0.30 -0.33 0.798 synthase kinase and PEP synthase CHARACTERIZ unknown pyrophosphorylase ED EcolC_1929 b1702 ppsA phosphoenolpyruvate synthase METABOLISM Carbohydrate -0.28 -0.64 -0.56 -0.92 0.029 transport and metabolism EcolC_1930 b1701 fadK short chain acyl-CoA synthetase, anaerobic METABOLISM Lipid 0.35 0.37 0.26 0.28 0.863 transport and metabolism EcolC_1932 b1699 ydiS predicted oxidoreductase with METABOLISM Energy 0.12 0.10 -0.06 -0.07 0.631 FAD/NAD(P)-binding domain production and conversion EcolC_1933 b1698 ydiR predicted electron transfer flavoprotein, METABOLISM Energy 0.03 0.03 -0.04 -0.03 0.784 FAD-binding subunit production and conversion EcolC_1934 b1697 ydiQ predicted electron transfer flavoprotein METABOLISM Energy 0.02 -0.07 -0.11 -0.20 0.169 subunit production and conversion EcolC_1935 b1696 ydiP predicted DNA-binding transcriptional INFORMATION Transcription 0.00 -0.17 0.01 -0.16 0.652 regulator STORAGE AND PROCESSING EcolC_1936 b1695 ydiO predicted acyl-CoA dehydrogenase METABOLISM Lipid 0.01 0.12 0.10 0.21 0.353 transport and metabolism EcolC_1937 b1694 ydiF fused predicted acetyl-CoA:acetoacetyl- METABOLISM Lipid -0.05 -0.04 -0.02 -0.01 0.679 CoA transferase: alpha subunit/beta transport and subunit metabolism EcolC_1938 b1693 aroD 3-dehydroquinate dehydratase METABOLISM Amino acid 0.07 0.40 0.18 0.50 0.277 transport and metabolism EcolC_1939 b1692 ydiB quinate/shikimate 5-dehydrogenase, METABOLISM Amino acid -0.22 0.02 -0.01 0.23 0.159 NAD(P)-binding transport and metabolism EcolC_1940 b1691 ydiN inner membrane protein, predicted MFS - - -0.54 -0.36 -0.39 -0.21 0.336 superfamily transporter EcolC_1941 b1690 ydiM inner membrane protein, predicted METABOLISM Carbohydrate -0.25 -0.11 -0.17 -0.02 0.295 transporter transport and metabolism EcolC_1942 b1689 ydiL conserved protein - - 0.18 0.18 0.25 0.25 0.858 EcolC_1943 b1688 ydiK inner membrane protein, UPF0118 family POORLY General -0.07 -0.04 -0.21 -0.18 0.883 CHARACTERIZ function ED prediction EcolC_1944 b1687 ydiJ predicted FAD-linked oxidoreductase METABOLISM Energyl -0.07 -0.06 -0.18 -0.17 0.592 production and conversion EcolC_1945 b1686 menI 1,4-dihydroxy-2-naphthoyl-CoA hydrolase METABOLISM Secondary 0.43 0.27 -0.20 -0.36 0.615 metabolites biosynthesis, transport and catabolism EcolC_1946 b1685 ydiH predicted protein - - -0.23 -0.03 -0.04 0.16 0.053 EcolC_1947 b1684 sufA Fe-S cluster assembly protein POORLY Function -0.46 -1.45 0.34 -0.64 0.006 CHARACTERIZ unknown ED EcolC_1948 b1683 sufB component of SufBCD Fe-S cluster CELLULAR Posttranslatio -0.63 -1.05 0.42 0.01 0.027 assembly scaffold PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1949 b1682 sufC SufBCD Fe-S cluster assembly scaffold CELLULAR Posttranslatio -0.44 -1.19 0.34 -0.41 0.005 protein, ATP-binding protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1950 b1681 sufD component of SufBCD Fe-S cluster CELLULAR Posttranslatio -0.07 -0.66 0.40 -0.18 0.055 assembly scaffold PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1951 b1680 sufS cysteine desulfurase, stimulated by SufE; METABOLISM Amino acid -0.31 -0.67 0.30 -0.07 0.025 selenocysteine lyase, PLP-dependent transport and metabolism EcolC_1952 b1679 sufE sulfur acceptor protein POORLY General -0.38 -0.75 0.44 0.07 0.060 CHARACTERIZ function ED prediction EcolC_1953 b1678 ynhG murein L,D-transpeptidase POORLY Functionl -1.38 -1.92 0.47 -0.07 0.053 CHARACTERIZ unknown ED EcolC_1954 b1677 lpp murein lipoprotein CELLULAR Cell 0.02 0.12 -0.01 0.08 0.418 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1955 b1676 pykF pyruvate kinase I METABOLISM Carbohydrate -0.12 -0.12 0.19 0.19 0.703 transport and metabolism EcolC_1956 b1675 ydhZ predicted protein - - -0.64 -0.32 0.22 0.55 0.167 EcolC_1957 b1674 ydhY predicted 4Fe-4S ferridoxin-type protein METABOLISM Energy -3.41 -2.15 0.16 1.43 0.001 production and conversion EcolC_1958 b1673 ydhV predicted oxidoreductase METABOLISM Energy -3.08 -1.91 0.02 1.20 0.014 production and conversion EcolC_1959 b1672 ydhW predicted protein - - -2.67 -1.48 -0.04 1.14 0.001 EcolC_1960 b1671 ydhX predicted 4Fe-4S ferridoxin-type protein METABOLISM Energy -0.94 -0.58 0.14 0.50 0.295 production and conversion EcolC_1961 b1670 ydhU predicted cytochrome METABOLISM Energy -1.74 -1.15 0.01 0.61 0.014 production and conversion EcolC_1962 b1669 ydhT conserved protein - - -1.93 -1.05 0.39 1.27 0.003 EcolC_1963 b1668 ydhS conserved protein with FAD/NAD(P)- POORLY Function 0.10 -0.10 0.51 0.31 0.261 binding domain CHARACTERIZ unknown ED EcolC_1964 b1667 ydhR predicted monooxygenase - - 0.57 0.08 0.19 -0.30 0.070 EcolC_1965 b1664 ydhQ conserved protein CELLULAR Cell -0.18 -0.09 -0.18 -0.08 0.566 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1966 b1663 mdtK multidrug efflux system transporter CELLULAR Defense 0.30 0.43 0.09 0.23 0.229 PROCESSES mechanisms AND SIGNALING EcolC_1967 b1662 ribC riboflavin synthase, alpha subunit METABOLISM Coenzyme 0.09 0.01 0.15 0.08 0.499 transport and metabolism EcolC_1968 b1661 cfa cyclopropane fatty acyl phospholipid CELLULAR Cell -0.25 0.00 0.44 0.69 0.039 synthase (unsaturated-phospholipid PROCESSES wall/membran methyltransferase) AND e/envelope SIGNALING biogenesis EcolC_1969 b1660 ydhC putative arabinose efflux transporter METABOLISM Carbohydrate -0.02 0.02 0.02 0.05 0.252 transport and metabolism EcolC_1971 b1658 purR DNA-binding transcriptional repressor, INFORMATION Transcription 0.07 0.14 0.16 0.22 0.425 hypoxanthine-binding STORAGE AND PROCESSING EcolC_1972 b1657 ydhP predicted transporter METABOLISM Carbohydrate -0.21 -0.11 -0.04 0.06 0.269 transport and metabolism EcolC_1973 b1656 sodB superoxide dismutase, Fe METABOLISM Inorganic ion 0.28 0.22 0.20 0.15 0.541 transport and metabolism EcolC_1975 b1654 grxD glutaredoxin-4 CELLULAR Posttranslatio 0.52 0.61 -0.05 0.04 0.606 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1976 b1653 lhr predicted ATP-dependent helicase POORLY General 0.22 0.22 0.05 0.05 0.284 CHARACTERIZ function ED prediction l EcolC_1977 b1652 rnt (RNase T) INFORMATION Replication, 0.19 0.40 0.16 0.38 0.280 STORAGE AND recombination PROCESSING and repair EcolC_1978 b1651 gloA glyoxalase I, Ni-dependent METABOLISM Amino acid -0.51 -0.21 -0.46 -0.16 0.125 transport and metabolism EcolC_1979 b1650 nemA chromate reductase, quinone reductase, METABOLISM Energy -0.09 -0.09 -0.52 -0.52 0.832 FMN-linked; N-Ethylmaleimide reductase; production old yellow enzyme and conversion EcolC_1980 b1649 nemR transcriptional repressor for the nemRA- INFORMATION Transcription 0.25 0.18 0.31 0.24 0.636 gloA operon, quinone-, glyoxal-, and STORAGE AND HOCl-activated PROCESSING EcolC_1981 b1648 ydhL conserved protein POORLY General 0.52 0.32 0.45 0.25 0.821 CHARACTERIZ function ED prediction EcolC_1982 b1647 ydhF predicted oxidoreductase POORLY Generall -0.66 0.19 -0.19 0.66 0.002 CHARACTERIZ function ED prediction EcolC_1983 b1646 sodC superoxide dismutase, Cu, Zn, periplasmic METABOLISM Inorganicl ion -0.43 -0.50 0.07 0.00 0.738 transport and metabolism EcolC_1984 b1645 ydhK predicted efflux protein (PET) component POORLY Function -0.48 -0.39 -0.35 -0.25 0.620 of YdhJK efflux pump CHARACTERIZ unknown ED EcolC_1985 b1644 ydhJ predicted membrane fusion protein (MFP) CELLULAR Defense 0.09 0.27 0.30 0.48 0.438 of YdhJK efflux pump PROCESSES mechanisms AND SIGNALING EcolC_1986 b1643 ydhI predicted inner membrane protein - - -0.08 0.03 0.15 0.26 0.693 EcolC_1987 b1642 slyA DNA-binding transcriptional activator INFORMATION Transcription -0.84 -0.49 0.06 0.40 0.175 STORAGE AND PROCESSING EcolC_1988 b1641 slyB outer membrane lipoprotein CELLULAR Cell 0.68 -0.16 0.16 -0.68 0.002 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_1989 b1640 anmK anhydro-N-acetylmuramic acid kinase CELLULAR Posttranslatio 0.38 0.94 0.18 0.74 0.307 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1990 b1639 mliC inhibitor of c-type lysozyme, membrane- POORLY General 0.42 0.31 0.03 -0.09 0.406 bound; predicted lipoprotein CHARACTERIZ function ED prediction EcolC_1991 b1638 pdxH pyridoxine 5'-phosphate oxidase METABOLISM Coenzymel 0.13 0.65 -0.02 0.50 0.418 transport and metabolism EcolC_1992 b1637 tyrS tyrosyl-tRNA synthetase INFORMATION Translation, 0.03 0.36 -0.24 0.09 0.020 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_1993 b1636 pdxY pyridoxamine kinase METABOLISM Coenzyme 0.13 0.31 0.13 0.30 0.739 transport and metabolism EcolC_1994 b1635 gstA glutathionine S-transferase CELLULAR Posttranslatio 0.61 0.26 0.00 -0.35 0.028 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_1995 b1634 dtpA dipeptide and tripeptide permease A METABOLISM Amino acid -0.53 -0.46 -0.31 -0.24 0.911 transport and metabolism EcolC_1996 b1633 nth DNA glycosylase and apyrimidinic (AP) INFORMATION Replication, -0.11 -0.06 -0.08 -0.04 0.970 lyase (endonuclease III) STORAGE AND recombination PROCESSING and repair EcolC_1997 b1632 rsxE electron transport complex inner membrane METABOLISM Energy 0.16 0.11 0.19 0.14 0.645 NADH-quinone reductase required for the production reduction of SoxR and conversion EcolC_1998 b1631 rsxG electron transport complex protein required METABOLISM Energy 0.03 0.03 -0.05 -0.05 0.910 for the reduction of SoxR production and conversion EcolC_1999 b1630 rsxD electron transport complex protein METABOLISM Energy -0.13 -0.13 -0.07 -0.07 0.965 required for the reduction of SoxR; production predicted membrane protein and conversion EcolC_2000 b1629 rsxC electron transport complex protein required METABOLISM Energy 0.05 0.11 -0.02 0.04 0.473 for the reduction of SoxR; predicted production membrane-associated NADH and oxidoreductase conversion EcolC_2001 b1628 rsxB electron transport complex protein, iron- METABOLISM Energy 0.15 -0.13 0.11 -0.16 0.062 sulfur protein, required for the reduction of production SoxR and conversion EcolC_2002 b1627 rsxA electron transport complex protein required METABOLISM Energy -0.24 -0.12 -0.22 -0.11 0.812 for the reduction of SoxR production and conversion EcolC_2003 b1626 ydgK inner membrane protein, DUF2569 family - - -0.68 -0.58 -0.52 -0.42 0.909 EcolC_2004 b1625 cnu oriC-binding complex H-NS/Cnu; binds 26 - - -0.21 -0.19 0.08 0.10 0.839 bp cnb site; also forms a complex with StpA EcolC_2005 b4409 blr beta-lactam resistance membrane protein; - - -0.46 -0.31 0.09 0.23 0.279 divisome-associated protein EcolC_2006 b1624 ydgJ predicted oxidoreductase POORLY General -0.01 0.09 -0.18 -0.08 0.859 CHARACTERIZ function ED prediction EcolC_2007 b1623 add adenosine deaminase METABOLISM Nucleotidel 0.80 0.79 -0.16 -0.17 0.863 transport and metabolism EcolC_2008 b1622 malY bifunctional beta-cystathionase, PLP- METABOLISM Amino acid -0.08 0.28 -0.09 0.27 0.037 dependent/ regulator of maltose regulon transport and metabolism EcolC_2010 b1620 malI transcriptional repressor of Mal regulon INFORMATION Transcription 0.42 0.49 -0.08 -0.01 0.380 STORAGE AND PROCESSING EcolC_2011 b1619 hdhA 7-alpha-hydroxysteroid dehydrogenase, METABOLISM Lipid 0.20 -0.25 0.24 -0.22 0.175 NAD-dependent transport and metabolism EcolC_2012 b1618 uidR DNA-binding transcriptional repressor INFORMATION Transcription 0.86 0.93 -0.08 -0.01 0.670 STORAGE AND PROCESSING EcolC_2013 b1617 uidA beta-D-glucuronidase METABOLISM Carbohydrate 1.06 0.84 -0.03 -0.25 0.830 transport and metabolism EcolC_2015 b1615 uidC predicted outer membrane porin protein - - 0.06 -0.11 -0.16 -0.33 0.528 EcolC_2016 b1614 ydgA conserved protein, DUF945 family POORLY Function -1.02 -1.30 0.18 -0.09 0.126 CHARACTERIZ unknown ED EcolC_2017 b1613 manA mannose-6-phosphate isomerase METABOLISM Carbohydrate -0.02 0.41 -0.06 0.37 0.036 transport and metabolism EcolC_2018 b1612 fumA fumarate hydratase (fumarase A), aerobic METABOLISM Energy 0.55 0.16 -0.01 -0.40 0.315 Class I production and conversion EcolC_2019 b1611 fumC fumarate hydratase (fumarase C),aerobic METABOLISM Energy 3.06 1.06 0.24 -1.76 0.014 Class II production and conversion EcolC_2020 b1610 tus inhibitor of replication at Ter, DNA- - - 0.18 0.12 0.06 0.00 0.743 binding protein EcolC_2021 b1609 rstB sensory histidine kinase in two-component CELLULAR Signal 0.19 0.22 0.03 0.05 0.999 regulatory system with RstA PROCESSES transduction AND mechanisms SIGNALING EcolC_2022 b1608 rstA multicopy supressor of yjeE, yeaZ or ygjD CELLULAR Signal 0.54 -0.01 0.06 -0.49 0.057 deletion lethality, predicted response PROCESSES transduction regulator of two-component regulatory AND mechanisms system with sensor protein RstB SIGNALING EcolC_2023 b1607 ydgC inner membrane protein, GlpM family POORLY General -0.30 -0.55 -0.19 -0.43 0.963 CHARACTERIZ function ED prediction EcolC_2024 b1606 folM dihydromonapterin reductase, NADPH- METABOLISM Lipidl 0.23 0.20 0.01 -0.03 0.880 dependent; dihydrofolate reductase transport and isozyme metabolism EcolC_2025 b1605 ydgI predicted arginine/ornithine antiporter METABOLISM Amino acid -0.31 -0.12 0.14 0.33 0.729 transporter transport and metabolism EcolC_2026 b1604 ydgH predicted protein - - -0.42 0.03 -0.23 0.22 0.024 EcolC_2027 b1603 pntA pyridine nucleotide transhydrogenase, METABOLISM Energy -0.04 0.15 -0.12 0.06 0.195 alpha subunit production and conversion EcolC_2028 b1602 pntB pyridine nucleotide transhydrogenase, beta METABOLISM Energy 0.23 0.25 0.19 0.21 0.910 subunit production and conversion EcolC_2029 b1601 tqsA pheromone AI-2 transporter POORLY General 0.42 0.39 0.20 0.18 0.967 CHARACTERI function ZED prediction only EcolC_2030 b1600 mdtJ multidrug efflux system transporter METABOLISM Inorganic ion -0.83 -0.72 -0.70 -0.59 0.495 transport and metabolism EcolC_2031 b1599 mdtI multidrug efflux system transporter METABOLISM Inorganic ion -0.01 -0.08 0.51 0.44 0.155 transport and metabolism EcolC_2032 b1598 ydgD predicted peptidase METABOLISM Amino acid -0.04 -0.19 0.13 -0.02 0.909 transport and metabolism EcolC_2033 b1597 asr acid shock-inducible periplasmic protein - - 1.86 2.59 0.67 1.41 0.062 EcolC_2034 b1596 ynfM putative arabinose efflux transporter METABOLISM Carbohydrate 0.18 1.24 0.12 1.18 0.007 transport and metabolism EcolC_2035 b1595 ynfL predicted DNA-binding transcriptional INFORMATION Transcription 0.35 0.30 0.27 0.22 0.815 regulator STORAGE AND PROCESSING EcolC_2036 b1594 mlc global DNA-binding transcriptional INFORMATION Transcription 0.58 0.70 0.14 0.26 0.765 repressor; autorepressor; required for STORAGE AND anaerobic growth on glucosamine PROCESSING EcolC_2037 b1593 ynfK predicted dethiobiotin synthetase METABOLISM Coenzyme -0.59 0.20 0.31 1.09 0.001 transport and metabolism EcolC_2038 b1592 clcB H(+)/Cl(-) exchange transporter METABOLISM Inorganic ion 0.05 0.38 0.44 0.77 0.194 transport and metabolism EcolC_2039 b1591 dmsD twin-argninine leader-binding protein for POORLY General -0.73 -0.57 -0.29 -0.12 0.292 DmsA and TorA CHARACTERIZ function ED prediction EcolC_2040 b1590 ynfH oxidoreductase, membrane subunit POORLY Generall -1.65 -0.90 -0.12 0.63 0.036 CHARACTERIZ function ED prediction EcolC_2041 b1589 ynfG oxidoreductase, Fe-S subunit METABOLISM Energyl -2.94 -1.30 -0.13 1.50 0.002 production and conversion EcolC_2042 b1588 ynfF S- and N-oxide reductase, A subunit, METABOLISM Energy -2.85 -1.34 -0.18 1.34 0.001 periplasmic production and conversion EcolC_2043 b1587 ynfE putative selenate reductase, periplasmic METABOLISM Energy -2.84 -1.68 -0.25 0.91 0.000 production and conversion EcolC_2044 b1586 ynfD predicted protein - - -0.34 -0.64 0.21 -0.09 0.036 EcolC_2045 b1585 ynfC lipoprotein, UPF0257 family - - 0.01 0.10 0.12 0.21 0.547 EcolC_2046 b1584 speG spermidine N1-acetyltransferase INFORMATION Translation, 0.67 0.28 0.17 -0.22 0.018 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2047 b1583 ynfB predicted protein - - 1.30 0.28 0.37 -0.65 0.005 EcolC_2048 b1582 ynfA inner membrane protein, UPF0060 family POORLY Function -0.34 -0.28 0.03 0.09 0.599 CHARACTERIZ unknown ED EcolC_2049 b1581 rspA bifunctional D-altronate/D-mannonate CELLULAR Cell -0.09 0.08 0.12 0.28 0.135 dehydratase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2050 b1580 rspB predicted oxidoreductase, Zn-dependent METABOLISM Amino acid 0.08 0.04 -0.05 -0.09 0.229 and NAD(P)-binding transport and metabolism EcolC_2052 b1579 intQ - - - 0.18 0.19 0.32 0.32 0.971 EcolC_2053 - - Excisionase - - 0.22 0.13 0.30 0.22 0.850 EcolC_2054 b1577 ydfE - - - 0.00 -0.04 0.05 0.01 0.650 EcolC_2055 b1576 ydfD Qin prophage; predicted protein - - -0.18 -0.12 -0.09 -0.02 0.944 EcolC_2056 b1573 ydfC conserved protein, Qin prophage - - 0.23 0.48 0.46 0.72 0.192 EcolC_2057 b1571 ydfA Qin prophage; predicted protein - - 0.20 0.24 0.25 0.29 0.571 EcolC_2058 b1570 dicA Qin prophage; predicted regulator for DicB INFORMATION Transcription -0.06 0.12 0.45 0.63 0.406 STORAGE AND PROCESSING EcolC_2059 b1569 dicC Qin prophage; DNA-binding - - 0.74 0.62 0.58 0.46 0.583 transcriptional regulator for DicB EcolC_2060 b1568 ydfX - - - 0.50 0.20 0.27 -0.03 0.040 EcolC_2061 - - hypothetical protein - - 0.40 0.26 0.31 0.17 0.543 EcolC_2069 b1567 intK - - - 0.12 0.04 0.15 0.07 0.406 EcolC_2070 b1566 flxA Qin prophage; predicted protein - - 0.22 0.17 0.29 0.24 0.160 EcolC_2071 b1564 relB Qin prophage; bifunctional antitoxin of the INFORMATION Replication, 0.86 0.58 0.18 -0.10 0.461 RelE-RelB toxin-antitoxin system/ STORAGE AND recombination transcriptional repressor PROCESSING and repair EcolC_2072 b1563 relE Qin prophage; toxin of the RelE-RelB INFORMATION Translation, 0.59 0.66 0.39 0.46 0.753 toxin-antitoxin system STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2073 b1562 hokD Qin prophage; small toxic polypeptide - - 1.07 0.91 0.52 0.36 0.646 EcolC_2074 b1561 rem Qin prophage; predicted protein - - -0.03 -0.07 0.09 0.05 0.909 EcolC_2076 b1560 ydfU Qin prophage; predicted protein - - 0.09 -0.01 0.10 0.00 0.399 EcolC_2077 b1559 quuQ Qin prophage; predicted antitermination CELLULAR Posttranslatio -0.18 -0.20 -0.13 -0.15 0.947 protein Q PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2079 b1557 cspB Qin prophage; cold shock protein INFORMATION Transcription 0.13 0.06 0.26 0.19 0.413 STORAGE AND PROCESSING EcolC_2081 b1556 essQ Qin prophage; predicted S lysis protein - - 0.07 -0.11 0.05 -0.13 0.442 EcolC_2082 b1555 ydfR Qin prophage; predicted protein - - -0.21 -0.07 -0.16 -0.02 0.205 EcolC_2083 - ydfQ-1 putative lysozyme POORLY General 0.02 -0.02 0.01 -0.03 0.312 CHARACTERIZ function ED prediction EcolC_2083 b1554 rrrQ Qin prophage; predicted lysozyme POORLY Generall 0.03 -0.14 0.08 -0.09 0.510 CHARACTERIZ function ED prediction EcolC_2084 b1553 rzpQ Rz-like protein, Qin prophage - -l -0.02 -0.04 0.15 0.13 0.641 EcolC_2085 b1552 cspI Qin prophage; cold shock protein INFORMATION Transcription 0.09 0.09 0.34 0.34 0.937 STORAGE AND PROCESSING EcolC_2086 b1551 ynfN Qin prophage; cold shock-induced protein - - 0.05 0.20 0.14 0.30 0.980 EcolC_2087 b1550 gnsB Qin prophage; multicopy suppressor of - - 0.40 0.77 0.46 0.82 0.152 secG(Cs) and fabA6(Ts) EcolC_2088 b1549 ydfO Qin prophage; predicted protein POORLY General 0.03 -0.19 -0.15 -0.37 0.084 CHARACTERIZ function ED prediction EcolC_2089 b4533 ynfO hypothetical protein, Qin prophage - -l -0.02 0.08 0.10 0.20 0.075 EcolC_2090 b1548 nohQ - - - 0.11 0.23 0.33 0.46 0.499 EcolC_2090 b0560 nohD DLP12 prophage; DNA packaging protein INFORMATION Replication, 0.14 0.13 0.14 0.14 0.863 STORAGE AND recombination PROCESSING and repair EcolC_2091 b0561 tfaD - - - -0.12 -0.08 -0.09 -0.05 0.263 EcolC_2111 b1547 stfQ Qin prophage; predicted side tail fibre - - 0.12 0.05 0.09 0.02 0.617 assembly protein EcolC_2112 b1373 tfaR Rac prophage; predicted tail fiber assembly POORLY General 0.06 0.12 0.10 0.16 0.834 protein CHARACTERIZ function ED prediction EcolC_2113 b1545 pinQ Qin prophage; predicted site-specific INFORMATION Replication,l 0.07 -0.01 0.02 -0.06 0.682 recombinase STORAGE AND recombination PROCESSING and repair EcolC_2113 b1374 pinR Rac prophage; predicted site-specific INFORMATION Replication, 0.10 -0.09 -0.01 -0.20 0.748 recombinase STORAGE AND recombination PROCESSING and repair EcolC_2114 b1375 ynaE cold shock protein, function unknown, Rac - - -0.18 -0.58 0.58 0.19 0.040 prophage EcolC_2116 b1542 ydfI predicted D-mannonate oxidoreductase, METABOLISM Carbohydrate 0.19 0.07 0.18 0.05 0.907 NAD-dependent transport and metabolism EcolC_2117 b1541 ydfZ selenoprotein, function unknown - - -0.04 -0.04 0.24 0.23 0.789 EcolC_2118 b1540 rspR transcriptional repressor for rspAB INFORMATION Transcription 0.35 0.47 0.45 0.58 0.508 STORAGE AND PROCESSING EcolC_2119 b1539 ydfG malonic semialdehyde reductase, NADPH- POORLY General -0.26 0.21 -0.04 0.43 0.031 dependent; L-allo-threonine CHARACTERIZ function dehydrogenase, NAD(P)-dependent; also ED prediction oxidizes L-serine, D-serine, D-threonine only and 3-hydroxyisobutyrate EcolC_2120 b1538 dcp dipeptidyl carboxypeptidase II METABOLISM Amino acid 0.04 0.00 0.06 0.02 0.535 transport and metabolism EcolC_2121 b1537 ydeJ conserved protein POORLY General -0.18 -0.16 -0.10 -0.08 0.850 CHARACTERIZ function ED prediction EcolC_2122 b1536 ydeI conserved protein POORLY Functionl 0.31 0.01 0.38 0.09 0.173 CHARACTERIZ unknown ED EcolC_2123 b1535 ydeH diguanylate cyclase, required for pgaD CELLULAR Signal 0.98 0.44 0.21 -0.33 0.041 induction PROCESSES transduction AND mechanisms SIGNALING EcolC_2124 b1534 ydeE predicted transporter METABOLISM Carbohydrate 0.08 0.06 0.21 0.19 0.842 transport and metabolism EcolC_2125 b1533 eamA cysteine and O-acetyl-L-serine efflux POORLY General 0.13 -0.05 0.03 -0.16 0.239 system CHARACTERIZ function ED prediction EcolC_2126 b1532 marB predicted protein - -l 0.48 0.12 0.11 -0.25 0.243 EcolC_2127 b1531 mar DNA-binding transcriptional dual activator INFORMATION Transcription 2.28 0.61 0.09 -1.58 0.016 of multiple antibiotic resistance STORAGE AND PROCESSING EcolC_2128 b1530 marR DNA-binding transcriptional repressor of INFORMATION Transcription 1.76 0.47 0.12 -1.17 0.007 multiple antibiotic resistance STORAGE AND PROCESSING EcolC_2129 b1529 marC inner membrane protein, UPF0056 family CELLULAR Intracellular -0.05 -0.04 0.07 0.08 0.686 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_2130 b1528 ydeA arabinose efflux transporter, arabinose- METABOLISM Carbohydrate -0.03 0.08 0.10 0.22 0.268 inducible transport and metabolism EcolC_2131 b1527 yneK predicted protein - - -0.17 -0.05 -0.11 0.01 0.942 EcolC_2132 b1526 yneJ predicted DNA-binding transcriptional INFORMATION Transcription 0.07 -0.02 0.09 -0.01 0.680 regulator STORAGE AND PROCESSING EcolC_2133 b1525 sad succinate semialdehyde dehydrogenase, METABOLISM Energy -2.14 -2.11 0.43 0.45 0.666 NAD(P)+-dependent production and conversion EcolC_2134 b1524 glsB glutaminase 2 METABOLISM Amino acid -0.21 -0.54 0.23 -0.11 0.138 transport and metabolism EcolC_2135 b1523 yneG conserved protein - - 0.05 0.46 0.33 0.75 0.104 EcolC_2136 b1522 yneF predicted membrane-bound diguanylate CELLULAR Signal 0.35 0.42 0.53 0.59 0.448 cyclase PROCESSES transduction AND mechanisms SIGNALING EcolC_2137 b1521 uxaB altronate oxidoreductase, NAD-dependent METABOLISM Carbohydrate -0.31 -0.33 -0.08 -0.09 0.744 transport and metabolism EcolC_2138 b1520 yneE predicted inner membrane protein, POORLY Function -0.03 -0.02 0.16 0.17 0.723 bestrophin family CHARACTERIZ unknown ED EcolC_2139 b1519 tam trans-aconitate methyltransferase POORLY General -0.57 -0.70 -0.48 -0.62 0.344 CHARACTERIZ function ED prediction EcolC_2140 b1518 lsrG autoinducer-2 (AI-2) degrading protein POORLY Functionl 0.33 0.21 0.14 0.02 0.851 LsrG CHARACTERIZ unknown ED EcolC_2141 b1517 lsrF putative autoinducer-2 (AI-2) aldolase METABOLISM Carbohydrate 0.37 0.16 -0.02 -0.24 0.245 transport and metabolism EcolC_2142 b1516 lsrB autoinducer 2-binding protein METABOLISM Carbohydrate 0.35 0.18 0.09 -0.07 0.369 transport and metabolism EcolC_2143 b1515 lsrD autoinducer 2 import system permease METABOLISM Carbohydrate 0.28 -0.14 -0.06 -0.48 0.238 protein transport and metabolism EcolC_2144 b1514 lsrC autoinducer 2 import system permease METABOLISM Carbohydrate 0.62 0.73 0.45 0.56 0.382 protein transport and metabolism EcolC_2145 b1513 lsrA autoinducer 2 import ATP-binding protein METABOLISM Carbohydrate 0.74 0.14 0.29 -0.31 0.014 transport and metabolism EcolC_2146 b1512 lsrR lsr operon transcriptional repressor INFORMATION Transcription 0.94 0.87 0.15 0.08 0.477 STORAGE AND PROCESSING EcolC_2149 b1508 hipB antitoxin of HipAB toxin-antitoxin system INFORMATION Transcription -0.02 0.03 0.13 0.18 0.878 STORAGE AND PROCESSING EcolC_2150 b1507 hipA EF-Tu kinase; serine protein kinase POORLY General 0.05 -0.37 0.03 -0.39 0.070 required for persister formation; toxin of CHARACTERIZ function HipAB TA pair ED prediction EcolC_2152 b1505 ydeT - - -l 0.25 0.06 -0.08 -0.27 0.251 EcolC_2153 b1504 ydeS predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.06 -0.09 -0.06 -0.10 0.597 PROCESSES AND SIGNALING EcolC_2154 b1503 ydeR predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.15 -0.03 -0.04 0.08 0.960 PROCESSES AND SIGNALING EcolC_2155 b1502 ydeQ predicted fimbrial-like adhesin protein - - -0.06 -0.13 -0.12 -0.18 0.439 EcolC_2156 b1501 ydeP predicted oxidoreductase METABOLISM Energy -0.04 -0.13 -0.10 -0.19 0.120 production and conversion EcolC_2158 b1499 ydeO UV-inducible global regulator, EvgA-, INFORMATION Transcription -0.14 -0.59 -0.16 -0.62 0.398 GadE-dependent STORAGE AND PROCESSING EcolC_2159 b1498 ydeN conserved protein METABOLISM Inorganic ion -0.29 -0.20 -0.11 -0.02 0.595 transport and metabolism EcolC_2160 b1497 ydeM conserved protein POORLY General -0.21 -0.15 -0.25 -0.18 0.625 CHARACTERIZ function ED prediction EcolC_2161 b1496 yddA fused predicted multidrug transporter POORLY Generall 0.24 -0.02 0.02 -0.24 0.208 subunits of ABC superfamily: membrane CHARACTERIZ function component/ATP-binding component ED prediction EcolC_2162 b1495 yddB predicted porin protein METABOLISM Inorganicl ion -0.12 -0.07 0.15 0.19 0.838 transport and metabolism EcolC_2163 b1494 pqqL predicted peptidase POORLY General -0.21 -0.19 -0.06 -0.03 0.190 CHARACTERIZ function ED prediction EcolC_2164 b1493 gadB glutamate decarboxylase B, PLP-dependent METABOLISM Aminol acid -0.58 -0.59 0.27 0.27 0.733 transport and metabolism EcolC_2165 b1492 gadC glutamate:gamma-aminobutyric acid METABOLISM Amino acid -1.26 -1.25 -0.18 -0.17 0.699 antiporter transport and metabolism EcolC_2166 b1491 yddW liprotein, glycosyl hydrolase homolog POORLY Function 0.01 -0.16 -0.06 -0.23 0.399 CHARACTERIZ unknown ED EcolC_2167 b1490 dosC diguanylate cyclase, cold- and stationary CELLULAR Signal 0.06 0.21 0.05 0.20 0.842 phase-induced oxygen-dependent biofilm PROCESSES transduction regulator AND mechanisms SIGNALING EcolC_2168 b1489 dosP oxygen sensor, c-di-GMP CELLULAR Signal 0.00 0.10 0.16 0.27 0.509 phosphodiesterase, heme-regulated; cold- PROCESSES transduction and stationary phase-induced bioflim AND mechanisms regulator SIGNALING EcolC_2169 b1488 ddpX D-ala-D-ala dipeptidase, Zn-dependent CELLULAR Cell 0.04 -0.18 -0.13 -0.35 0.508 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2170 b1487 ddpA D-ala-D-a la transporter subunit METABOLISM Amino acid -0.14 -0.09 -0.05 0.01 0.631 transport and metabolism EcolC_2171 b1486 ddpB D-ala-D-ala transporter subunit METABOLISM Amino acid -0.11 -0.17 -0.08 -0.15 0.995 transport and metabolism EcolC_2173 b1484 ddpD D,D-dipeptide permease system, ATP- METABOLISM Amino acid 0.36 0.30 0.18 0.12 0.900 binding component transport and metabolism EcolC_2174 b1483 ddpF D,D-dipeptide permease system, ATP- METABOLISM Amino acid 0.07 0.02 -0.06 -0.10 0.799 binding component transport and metabolism EcolC_2175 b1482 osmC lipoyl-dependent Cys-based peroxidase, CELLULAR Posttranslatio -0.47 -0.40 0.13 0.20 0.597 hydroperoxide resistance; salt-shock PROCESSES nal inducible membrane protein; peroxiredoxin AND modification, SIGNALING protein turnover, chaperones EcolC_2176 b1481 bdm biofilm-dependent modulation protein - - 0.18 0.02 -0.01 -0.17 0.479 EcolC_2177 b1480 sra stationary-phase-induced ribosome- - - 0.20 0.33 -0.03 0.11 0.292 associated protein EcolC_2178 b1479 maeA malate dehydrogenase, (decarboxylating, METABOLISM Energy 1.61 1.00 0.16 -0.44 0.000 NAD-requiring) (malic enzyme) production and conversion EcolC_2179 b1478 adhP ethanol-active POORLY General 0.27 0.44 0.13 0.30 0.145 dehydrogenase/acetaldehyde-active CHARACTERIZ function reductase ED prediction EcolC_2180 b1477 yddM predicted DNA-binding transcriptional POORLY Generall 0.30 0.40 0.31 0.41 0.233 regulator CHARACTERIZ function ED prediction EcolC_2181 b1476 fdnI formate dehydrogenase-N, cytochrome METABOLISM Energyl -0.07 -0.11 0.08 0.05 0.751 B556 (gamma) subunit, nitrate-inducible production and conversion EcolC_2182 b1475 fdnH formate dehydrogenase-N, Fe-S (beta) METABOLISM Energy 0.30 -0.16 0.33 -0.13 0.026 subunit, nitrate-inducible production and conversion EcolC_2183 b1474 fdnG formate dehydrogenase-N, alpha subunit, METABOLISM Energy -0.04 -0.06 0.09 0.07 0.787 nitrate-inducible production and conversion EcolC_2184 b1473 yddG aromatic amino acid exporter - - -0.03 -0.07 0.16 0.12 0.830 EcolC_2185 b1472 yddL - - - -0.10 -0.19 -0.07 -0.17 0.851 EcolC_2186 b1471 yddK - - - -0.52 -0.53 -0.24 -0.26 0.680 EcolC_2187 b1469 narU nitrate/nitrite transporter METABOLISM Inorganic ion -0.09 -0.73 -0.10 -0.74 0.026 transport and metabolism EcolC_2188 b1468 narZ nitrate reductase 2 (NRZ), alpha subunit METABOLISM Energy -0.26 -0.73 0.19 -0.28 0.274 production and conversion EcolC_2189 b1467 narY nitrate reductase 2 (NRZ), beta subunit METABOLISM Energy -0.26 -0.90 0.43 -0.21 0.175 production and conversion EcolC_2190 b1466 narW nitrate reductase 2 (NRZ), delta subunit METABOLISM Energy -0.06 -0.65 0.57 -0.02 0.112 (assembly subunit) production and conversion EcolC_2191 b1465 narV nitrate reductase 2 (NRZ), gamma subunit METABOLISM Energy 0.04 -0.09 0.46 0.33 0.104 production and conversion EcolC_2193 b1463 nhoA N-hydroxyarylamine O-acetyltransferase METABOLISM Secondary 0.00 0.04 -0.11 -0.07 0.814 metabolites biosynthesis, transport and catabolism EcolC_2194 b1462 yddH conserved protein POORLY General -0.09 -0.03 0.05 0.11 0.902 CHARACTERIZ function ED prediction EcolC_2195 b1461 pptA 4-oxalocrotonate tautomerase POORLY Generall -0.04 -0.07 0.07 0.03 0.527 CHARACTERIZ function ED prediction EcolC_2202 - - hypothetical protein POORLY Functionl 0.54 0.43 0.49 0.37 0.579 CHARACTERIZ unknown ED EcolC_2203 b0705 ybfL - - - 0.05 -0.12 0.15 -0.03 0.302 EcolC_2206 b1453 ansP L-asparagine transporter METABOLISM Amino acid -0.16 -0.15 0.04 0.06 0.956 transport and metabolism EcolC_2207 b1452 yncE ATP-binding protein, periplasmic, function POORLY Function -0.03 0.03 -0.06 0.00 0.824 unknown CHARACTERIZ unknown ED EcolC_2208 b1451 yncD predicted iron outer membrane transporter METABOLISM Inorganic ion -0.14 -0.29 -0.09 -0.23 0.796 transport and metabolism EcolC_2209 b1450 mcbR colanic acid and biofilm gene INFORMATION Transcription 0.25 -0.01 0.25 0.00 0.223 transcriptional regulator, MqsR-controlled STORAGE AND PROCESSING EcolC_2210 b1449 curA curcumin/dihydrocurcumin reductase, POORLY General 0.03 0.63 -0.32 0.27 0.022 NADPH-dependent CHARACTERIZ function ED prediction EcolC_2211 b1448 mnaT methionine N-acyltransferase; L-amino CELLULAR Celll -0.06 0.15 0.18 0.40 0.329 acid N-acyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2212 b1447 ydcZ inner membrane protein, DUF606 family POORLY Function 0.07 0.22 0.20 0.35 0.651 CHARACTERIZ unknown ED EcolC_2213 b1446 ydcY predicted protein - - 0.16 0.39 0.23 0.45 0.293 EcolC_2214 b1445 ydcX conserved protein, DUF2566 family - - -0.46 -0.51 -0.30 -0.36 0.941 EcolC_2215 b1444 patD gamma-aminobutyraldehyde METABOLISM Energy -0.47 -0.35 -0.28 -0.16 0.640 dehydrogenase production and conversion EcolC_2216 b1443 ydcV predicted spermidine/putrescine transporter METABOLISM Amino acid -0.10 -0.03 0.11 0.18 0.467 subunit transport and metabolism EcolC_2217 b1442 ydcU predicted spermidine/putrescine transporter METABOLISM Amino acid -0.11 -0.27 -0.03 -0.19 0.655 subunit transport and metabolism EcolC_2218 b1441 ydcT predicted spermidine/putrescine transporter METABOLISM Amino acid -0.05 -0.18 -0.19 -0.31 0.960 subunit transport and metabolism EcolC_2219 b1440 ydcS polyhydroxybutyrate (PHB) synthase, ABC METABOLISM Amino acid 0.05 0.03 0.22 0.20 0.738 transporter periplasmic binding protein transport and homolog metabolism EcolC_2220 b1439 ydcR fused predicted DNA-binding INFORMATION Transcription 0.01 0.06 0.01 0.05 0.962 transcriptional regulator/predicted amino STORAGE AND transferase PROCESSING EcolC_2221 b1438 hicB antitoxin for the HicAB toxin-antitoxin POORLY Function 0.07 -0.05 0.08 -0.04 0.939 system CHARACTERIZ unknown ED EcolC_2222 b4532 hicA mRNA interferase toxin of the HicAB - - 0.39 0.64 0.04 0.29 0.469 toxin-antitoxin system EcolC_2223 b1436 yncJ predicted protein - - 0.39 0.07 0.14 -0.18 0.255 EcolC_2224 b1435 ydcP predicted peptidase CELLULAR Posttranslatio 0.10 -0.13 -0.01 -0.24 0.753 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2225 b1434 ydcN predicted DNA-binding transcriptional INFORMATION Transcription -0.21 0.08 -0.01 0.28 0.343 regulator STORAGE AND PROCESSING EcolC_2226 b1433 ydcO inner membrane protein, predicted METABOLISM Secondary -0.48 -0.52 -0.43 -0.48 0.751 transporter, function unknown metabolites biosynthesis, transport and catabolism EcolC_2227 b1432 insQ IS609 transposase B INFORMATION Replication, -0.09 0.12 0.12 0.34 0.482 STORAGE AND recombination PROCESSING and repair EcolC_2229 b1431 ydcL lipoprotein - - 0.76 0.06 0.13 -0.57 0.010 EcolC_2230 b1430 tehB tellurite, selenium methyltransferase, INFORMATION Translation, 0.24 0.59 0.09 0.45 0.094 SAM-dependent; tellurite, selenium STORAGE AND ribosomal resistance protein PROCESSING structure and biogenesis EcolC_2231 b1429 tehA potassium-tellurite ethidium and proflavin METABOLISM Inorganic ion -0.12 -0.26 -0.29 -0.43 0.644 transporter transport and metabolism EcolC_2232 b1428 ydcK predicted enzyme CELLULAR Cell -0.07 -0.07 0.01 0.01 0.578 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2234 b1426 ydcH DUF465 family protein, function unknown POORLY Function 0.66 0.46 0.36 0.15 0.589 CHARACTERIZ unknown ED EcolC_2235 b1424 opgD osmoregulated periplasmic glucan (OPG) METABOLISM Inorganic ion 0.20 -0.01 0.12 -0.10 0.576 biosynthesis periplasmic protein transport and metabolism EcolC_2236 b1423 ydcJ predicted metalloenzyme POORLY Function 0.46 0.22 0.14 -0.11 0.167 CHARACTERIZ unknown ED EcolC_2238 b1421 trg methyl-accepting chemotaxis protein III, CELLULAR Cell motility -0.08 0.05 -0.15 -0.02 0.412 ribose and galactose sensor receptor PROCESSES AND SIGNALING EcolC_2239 b4428 hokB toxic polypeptide, small - - 0.38 0.85 0.32 0.80 0.107 EcolC_2240 b1419 ydcA predicted protein - - -0.62 -0.32 -0.14 0.16 0.236 EcolC_2241 b1418 cybB cytochrome b561 METABOLISM Energy -0.18 -0.72 -0.14 -0.69 0.001 production and conversion EcolC_2242 b4493 gapC - - - 0.23 -0.21 0.14 -0.30 0.167 EcolC_2243 b1415 aldA aldehyde dehydrogenase A, NAD-linked METABOLISM Energy 0.46 0.04 0.01 -0.41 0.270 production and conversion EcolC_2244 b1414 ydcF conserved SAM-binding protein, DUF218 POORLY Function 0.13 0.16 0.04 0.07 0.546 family CHARACTERIZ unknown ED EcolC_2245 b1413 hrpA predicted ATP-dependent helicase INFORMATION Replication, 0.17 0.52 -0.05 0.30 0.544 STORAGE AND recombination PROCESSING and repair EcolC_2246 b1412 azoR NADH-azoreductase, FMN-dependent METABOLISM Lipid 0.15 0.16 -0.06 -0.05 0.519 transport and metabolism EcolC_2247 b1411 ynbD predicted phosphatase inner membrane CELLULAR Signal -0.90 -0.75 -0.75 -0.60 0.837 protein PROCESSES transduction AND mechanisms SIGNALING EcolC_2249 b1409 ynbB predicted CDP-diglyceride synthase POORLY General -0.79 -0.36 -0.41 0.02 0.234 CHARACTERIZ function ED prediction EcolC_2250 b1408 ynbA inner membrane protein METABOLISM Lipidl -0.35 -0.37 -0.31 -0.33 0.887 transport and metabolism EcolC_2251 b1407 ydbD predicted PF10971 family periplasmic - - -0.13 -0.04 -0.09 0.00 0.362 methylglyoxal resistance protein EcolC_2252 b1406 ydbC predicted oxidoreductase, NAD(P)-binding METABOLISM Energy 0.06 0.70 -0.19 0.45 0.022 production and conversion EcolC_2255 b1400 paaY predicted hexapeptide repeat POORLY General 0.61 0.23 0.19 -0.19 0.190 acetyltransferase CHARACTERIZ function ED prediction EcolC_2256 b1399 paaX DNA-binding transcriptional repressor of INFORMATION Transcriptionl 0.90 0.50 0.24 -0.17 0.217 phenylacetic acid degradation paa operon, STORAGE AND phenylacetyl-CoA inducer PROCESSING EcolC_2257 b1398 paaK phenylacetyl-CoA ligase METABOLISM Coenzyme 0.59 0.09 0.05 -0.45 0.083 transport and metabolism EcolC_2259 b1396 paaI , most active with ring- METABOLISM Secondary 0.31 0.13 0.19 0.02 0.535 hydroxylated phenylacetyl-coenzyme A metabolites thioesters biosynthesis, transport and catabolism EcolC_2260 b1395 paaH 3-hydroxyadipyl-CoA dehydrogenase, METABOLISM Lipid 0.47 0.01 -0.01 -0.47 0.036 NAD+-dependent transport and metabolism EcolC_2261 b1394 paaG 1,2-epoxyphenylacetyl-CoA isomerase, METABOLISM Lipid 0.99 -0.04 0.09 -0.94 0.002 oxepin-CoA-forming transport and metabolism EcolC_2263 b1392 paaE ring 1,2-phenylacetyl-CoA epoxidase, METABOLISM Energy 0.77 -0.51 0.03 -1.25 0.002 NAD(P)H oxidoreductase component production and conversion EcolC_2264 b1391 paaD ring 1,2-phenylacetyl-CoA epoxidase POORLY General 0.98 -0.03 0.13 -0.88 0.026 subunit CHARACTERIZ function ED prediction l EcolC_2265 b1390 paaC ring 1,2-phenylacetyl-CoA epoxidase POORLY Function 0.85 -0.04 -0.01 -0.90 0.156 subunit CHARACTERIZ unknown ED EcolC_2266 b1389 paaB ring 1,2-phenylacetyl-CoA epoxidase METABOLISM Secondary 0.99 0.07 0.11 -0.82 0.050 possible subunit, not required for in vitro metabolites activity biosynthesis, transport and catabolism EcolC_2267 b1388 paaA ring 1,2-phenylacetyl-CoA epoxidase POORLY Function 0.76 -0.01 0.02 -0.75 0.026 subunit CHARACTERIZ unknown ED EcolC_2268 b1387 paaZ fused oxepin-CoA hydrolase/3-oxo-5,6- METABOLISM Energy 0.05 0.02 -0.12 -0.15 0.696 dehydrosuberyl-CoA semialdehyde production dehydrogenase and conversion EcolC_2269 b1386 tynA tyramine oxidase, copper-requiring METABOLISM Secondary -0.19 -0.10 -0.14 -0.06 0.657 metabolites biosynthesis, transport and catabolism EcolC_2270 b1385 feaB phenylacetaldehyde dehydrogenase METABOLISM Energy 0.09 0.02 -0.15 -0.22 0.657 production and conversion EcolC_2271 b1384 feaR DNA-binding transcriptional activator for INFORMATION Transcription 0.69 0.00 0.18 -0.51 0.625 tynA and feaB STORAGE AND PROCESSING EcolC_2272 b1383 ydbL conserved protein POORLY Function -0.10 -0.34 -0.06 -0.31 0.225 CHARACTERIZ unknown ED EcolC_2273 b1382 ynbE lipoprotein - - -0.01 0.06 0.15 0.23 0.751 EcolC_2274 b1381 ydbH predicted protein - - 0.37 0.35 0.07 0.05 0.751 EcolC_2275 b1380 ldhA fermentative D-lactate dehydrogenase, METABOLISM Energy -0.10 -0.19 -0.12 -0.21 0.713 NAD-dependent production and conversion EcolC_2276 b1379 hslJ heat-inducible lipoprotein involved in CELLULAR Posttranslatio 0.39 0.56 0.32 0.50 0.437 novobiocin resistance PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2277 b4529 ydbJ predicted lipoprotein, DUF333 family POORLY General 0.48 0.42 0.09 0.03 0.862 CHARACTERIZ function ED prediction EcolC_2278 b1378 ydbK fused predicted pyruvate-flavodoxin METABOLISM Energyl 1.04 0.24 0.24 -0.56 0.244 oxidoreductase: conserved production protein/conserved protein/FeS binding and protein conversion EcolC_2279 b1377 ompN outer membrane pore protein N, non- CELLULAR Cell -0.02 -0.28 -0.10 -0.36 0.458 specific PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2280 b1376 uspF stress-induced protein, ATP-binding CELLULAR Signal -2.03 -2.01 0.02 0.03 0.666 protein PROCESSES transduction AND mechanisms SIGNALING EcolC_2281 b1344 ttcA tRNA 2-thiocytidine biosynthesis protein CELLULAR Cell cycle 0.11 0.23 0.22 0.33 0.676 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2282 b1343 dbpA ATP-dependent RNA helicase, specific for INFORMATION Replication, -0.06 -0.05 0.04 0.04 0.750 23S rRNA STORAGE AND recombination PROCESSING and repair EcolC_2283 b1342 ydaN predicted Zn(II) transporter METABOLISM Inorganic ion -0.39 -0.46 -0.21 -0.28 0.894 transport and metabolism EcolC_2284 b1341 ydaM diguanylate cyclase, csgD regulator CELLULAR Signal -0.03 -0.21 0.08 -0.09 0.419 PROCESSES transduction AND mechanisms SIGNALING EcolC_2285 b1340 smrA DNA endonuclease POORLY Function -0.01 -0.10 0.01 -0.09 0.974 CHARACTERIZ unknown ED EcolC_2286 b1339 abgR predicted DNA-binding transcriptional INFORMATION Transcription 0.45 -0.26 0.04 -0.67 0.125 regulator of abgABT operon STORAGE AND PROCESSING EcolC_2287 b1338 abgA p-aminobenzoyl-glutamate hydrolase, A POORLY General -0.12 -0.26 -0.11 -0.24 0.325 subunit CHARACTERIZ function ED prediction EcolC_2288 b1337 abgB p-aminobenzoyl-glutamate hydrolase, B POORLY Generall 0.20 0.27 0.14 0.20 0.679 subunit CHARACTERIZ function ED prediction EcolC_2289 b1336 abgT p-aminobenzoyl-glutamate transporter; METABOLISM Coenzymel 0.06 0.06 0.08 0.08 0.499 membrane protein transport and metabolism EcolC_2290 b1335 ogt O-6-alkylguanine-DNA:cysteine-protein INFORMATION Replication, 0.19 0.24 -0.01 0.03 0.671 methyltransferase STORAGE AND recombination PROCESSING and repair EcolC_2291 b1334 fnr DNA-binding transcriptional dual CELLULAR Signal 0.64 0.72 0.11 0.19 0.939 regulator, global regulator of anaerobic PROCESSES transduction growth AND mechanisms SIGNALING EcolC_2292 b1333 uspE stress-induced protein CELLULAR Signal -0.09 -0.84 0.10 -0.65 0.143 PROCESSES transduction AND mechanisms SIGNALING EcolC_2293 b1332 ynaJ predicted inner membrane protein, - - 0.24 0.18 0.07 0.01 0.828 DUF2534 family EcolC_2294 b1330 ynaI mechanosensitive channel protein, very CELLULAR Cell -0.35 -0.38 -0.26 -0.28 0.971 small conductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2295 b1329 mppA murein tripeptide (L-ala-gamma-D- METABOLISM Amino acid 0.47 -0.03 0.05 -0.45 0.010 glutamyl-meso-DAP) transporter subunit transport and metabolism EcolC_2296 b1328 pgrR murein peptide degradation regulator INFORMATION Transcription -0.14 -0.21 -0.11 -0.18 0.514 STORAGE AND PROCESSING EcolC_2299 b1326 mpaA murein peptide amidase A METABOLISM Amino acid 0.33 0.36 0.24 0.27 0.740 transport and metabolism EcolC_2300 b1325 ycjG L-Ala-D/L-Glu epimerase CELLULAR Cell 0.30 0.32 0.12 0.14 0.928 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2301 b1324 tpx lipid hydroperoxide peroxidase CELLULAR Posttranslatio 0.19 0.20 -0.03 -0.03 0.825 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2302 b1323 tyrR DNA-binding transcriptional dual INFORMATION Transcription 0.03 0.17 0.02 0.17 0.843 regulator, tyrosine-binding STORAGE AND PROCESSING EcolC_2303 b1322 ycjF inner membrane protein, UPF0283 family POORLY Function 0.07 0.06 -0.02 -0.03 0.856 CHARACTERIZ unknown ED EcolC_2304 b1321 ycjX conserved protein with nucleoside POORLY General 0.61 0.32 0.09 -0.21 0.336 triphosphate hydrolase domain CHARACTERIZ function ED prediction EcolC_2305 b1320 ycjW predicted DNA-binding transcriptional INFORMATION Transcriptionl -0.12 -0.12 -0.15 -0.15 0.603 regulator STORAGE AND PROCESSING EcolC_2306 b1319 ompG outer membrane porin G - - -0.08 -0.12 -0.03 -0.08 0.852 EcolC_2307 b4524 ycjV - - - -0.26 -0.24 -0.20 -0.18 0.408 EcolC_2308 b1317 ycjU beta-phosphoglucomutase POORLY General -0.16 -0.24 -0.17 -0.25 0.204 CHARACTERIZ function ED prediction EcolC_2309 b1316 ycjT predicted hydrolase METABOLISM Carbohydratel -0.12 -0.08 -0.17 -0.13 0.884 transport and metabolism EcolC_2310 b1315 ycjS predicted oxidoreductase, NADH-binding POORLY General 0.08 0.12 0.15 0.18 0.911 CHARACTERIZ function ED prediction EcolC_2311 b1314 ycjR predicted enzyme METABOLISM Carbohydratel 0.02 0.02 0.09 0.09 0.944 transport and metabolism EcolC_2312 b1313 ycjQ predicted oxidoreductase, Zn-dependent METABOLISM Amino acid 0.15 -0.12 -0.18 -0.45 0.032 and NAD(P)-binding transport and metabolism EcolC_2313 b1312 ycjP predicted sugar transporter subunit: METABOLISM Carbohydrate 0.05 -0.11 0.00 -0.15 0.322 membrane component of ABC superfamily transport and metabolism EcolC_2314 b1311 ycjO predicted sugar transporter subunit: METABOLISM Carbohydrate -0.03 -0.03 -0.17 -0.17 0.736 membrane component of ABC superfamily transport and metabolism EcolC_2315 b1310 ycjN predicted sugar transporter subunit: METABOLISM Carbohydrate -0.04 -0.21 -0.07 -0.24 0.617 periplasmic-binding component of ABC transport and superfamily metabolism EcolC_2316 b1309 ycjM predicted glucosyltransferase METABOLISM Carbohydrate 0.09 -0.14 -0.29 -0.52 0.389 transport and metabolism EcolC_2317 b1308 pspE thiosulfate:cyanide sulfurtransferase METABOLISM Inorganic ion 1.20 1.38 -0.04 0.14 0.317 (rhodanese) transport and metabolism EcolC_2318 b1307 pspD peripheral inner membrane phage-shock - - 2.58 0.12 0.17 -2.28 0.002 protein EcolC_2319 b1306 pspC DNA-binding transcriptional activator INFORMATION Transcription 2.86 -0.20 -0.34 -3.40 0.006 STORAGE AND PROCESSING EcolC_2320 b1305 pspB DNA-binding transcriptional regulator of - - 2.84 0.27 -0.05 -2.62 0.003 psp operon EcolC_2321 b1304 pspA regulatory protein for phage-shock-protein INFORMATION Transcription 2.88 0.27 0.03 -2.58 0.011 operon STORAGE AND PROCESSING EcolC_2322 b1303 pspF DNA-binding transcriptional activator INFORMATION Transcription 0.35 0.17 0.20 0.02 0.218 STORAGE AND PROCESSING EcolC_2323 b1302 puuE GABA aminotransferase, PLP-dependent METABOLISM Amino acid -0.17 -0.10 -0.13 -0.06 0.640 transport and metabolism EcolC_2324 b1301 puuB gamma-Glu-putrescine oxidase, METABOLISM Amino acid -0.06 -0.29 -0.10 -0.33 0.169 FAD/NAD(P)-binding transport and metabolism EcolC_2325 b1300 puuC gamma-Glu-gamma-aminobutyraldehyde METABOLISM Energy 0.11 0.01 -0.05 -0.14 0.408 dehydrogenase, NAD(P)H-dependent production and conversion EcolC_2326 b1299 puuR DNA-binding transcriptional repressor for INFORMATION Transcription 0.07 -0.10 -0.01 -0.17 0.286 the puu divergon STORAGE AND PROCESSING EcolC_2328 b1297 puuA gamma-Glu-putrescine synthase METABOLISM Amino acid -0.02 -0.20 -0.17 -0.35 0.011 transport and metabolism EcolC_2329 b1296 puuP putrescine importer METABOLISM Amino acid -0.08 -0.15 0.08 0.02 0.454 transport and metabolism EcolC_2330 b1295 ymjA predicted protein - - 0.18 -0.09 0.06 -0.21 0.180 EcolC_2331 b1294 sapA antimicrobial peptide transport ABC METABOLISM Amino acid 0.50 0.65 0.27 0.42 0.740 transporter periplasmic binding protein transport and metabolism EcolC_2332 b1293 sapB antimicrobial peptide transport ABC CELLULAR Defense -0.46 -0.48 -0.42 -0.43 0.838 transporter permease PROCESSES mechanisms AND SIGNALING EcolC_2333 b1292 sapC antimicrobial peptide transport ABC CELLULAR Defense 0.09 -0.02 0.00 -0.10 0.767 transporter permease PROCESSES mechanisms AND SIGNALING EcolC_2334 b1291 sapD antimicrobial peptide transport ABC CELLULAR Defense -0.08 -0.19 -0.04 -0.16 0.462 system ATP-binding protein PROCESSES mechanisms AND SIGNALING EcolC_2335 b1290 sapF antimicrobial peptide transport ABC CELLULAR Defense 0.13 0.21 0.18 0.27 0.460 system ATP-binding protein PROCESSES mechanisms AND SIGNALING EcolC_2336 b1289 ycjD conserved protein POORLY Function 0.10 0.34 -0.06 0.18 0.937 CHARACTERIZ unknown ED EcolC_2337 b1288 fabI enoyl-[acyl-carrier-protein] reductase, METABOLISM Lipid 0.58 1.00 -0.18 0.24 0.079 NADH-dependent transport and metabolism EcolC_2338 b1287 yciW predicted oxidoreductase POORLY Function 0.14 -0.04 -0.29 -0.48 0.175 CHARACTERIZ unknown ED EcolC_2339 b1286 rnb ribonuclease II INFORMATION Transcription -0.09 0.03 -0.12 0.00 0.555 STORAGE AND PROCESSING EcolC_2340 b1285 gmr cyclic-di-GMP phosphodiesterase; csgD CELLULAR Signal 0.11 -0.07 0.03 -0.15 0.663 regulator; modulator of Rnase II stability PROCESSES transduction AND mechanisms SIGNALING EcolC_2342 b1284 yciT global regulator of transcription; DeoR INFORMATION Transcription -0.05 0.07 0.13 0.25 0.573 family STORAGE AND PROCESSING EcolC_2343 b1283 osmB lipoprotein - - 0.99 0.64 0.12 -0.22 0.205 EcolC_2344 b1282 yciH initiation factor function partial mimic, INFORMATION Translation, 0.10 0.12 -0.01 0.01 0.829 SUI1 family STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2345 b1281 pyrF orotidine-5'-phosphate decarboxylase METABOLISM Nucleotide 0.18 0.40 0.14 0.35 0.140 transport and metabolism EcolC_2346 b1280 yciM TPR-repeats-containing protein METABOLISM Carbohydrate 0.12 0.08 -0.05 -0.09 0.589 transport and metabolism EcolC_2347 b1279 yciS DUF1049 family inner membrane protein, POORLY Function 0.08 0.48 -0.05 0.34 0.003 function unknown CHARACTERIZ unknown ED EcolC_2348 b1278 pgpB phosphatidylglycerophosphatase B METABOLISM Lipid 0.30 0.16 0.10 -0.04 0.398 transport and metabolism EcolC_2349 b1277 ribA GTP cyclohydrolase II METABOLISM Coenzyme 0.45 0.34 0.08 -0.02 0.322 transport and metabolism EcolC_2350 b1276 acnA aconitate hydratase 1 METABOLISM Energy 2.28 0.45 0.01 -1.82 0.001 production and conversion EcolC_2351 b4523 yciX hypothetical protein - - -0.11 -0.07 0.26 0.30 0.838 EcolC_2352 b4522 ymiA hypothetical protein - - -0.41 -0.55 0.40 0.26 0.302 EcolC_2353 b1275 cysB DNA-binding transcriptional dual INFORMATION Transcription -0.56 -0.25 -0.53 -0.23 0.052 regulator, O-acetyl-L-serine-binding STORAGE AND PROCESSING EcolC_2354 b1274 topA DNA topoisomerase I, omega subunit INFORMATION Replication, 0.03 -0.12 -0.13 -0.27 0.990 STORAGE AND recombination PROCESSING and repair EcolC_2355 b1273 yciN DUF2498 protein YciN - - 0.45 0.49 -0.07 -0.04 0.850 EcolC_2356 b1272 sohB predicted inner membrane peptidase; CELLULAR Posttranslatio 0.33 0.31 0.02 0.00 0.737 multicopy suppressor of htrA(degP) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2357 b1271 yciK predicted oxoacyl-(acyl carrier protein) METABOLISM Lipid 0.33 0.03 0.11 -0.20 0.252 reductase, EmrKY-TolC system transport and metabolism EcolC_2358 b1270 btuR cob(I)alamin METABOLISM Coenzyme 0.32 0.22 0.05 -0.04 0.858 adenolsyltransferase/cobinamide ATP- transport and dependent adenolsyltransferase metabolism EcolC_2359 b1269 rluB 23S rRNA pseudouridine(2605) synthase INFORMATION Translation, -0.05 -0.02 0.16 0.19 0.773 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2360 b1268 yciQ predicted inner membrane protein - - 0.17 0.00 -0.01 -0.18 0.314 EcolC_2361 b1267 yciO predicted RNA binding protein INFORMATION Translation, 0.38 0.10 -0.04 -0.32 0.047 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2362 b1266 yciV conserved protein POORLY General 0.24 -0.02 -0.02 -0.27 0.046 CHARACTERIZ function ED prediction EcolC_2364 b1263 trpD fused glutamine amidotransferase METABOLISM Aminol acid 0.08 0.31 -0.28 -0.05 0.919 (component II) of anthranilate transport and synthase/anthranilate phosphoribosyl metabolism transferase EcolC_2365 b1262 trpC fused indole-3-glycerolphosphate METABOLISM Amino acid -0.08 -0.68 -0.03 -0.62 0.005 synthetase/N-(5- transport and phosphoribosyl)anthranilate isomerase metabolism EcolC_2366 b1261 trpB tryptophan synthase, beta subunit METABOLISM Amino acid -0.33 -0.56 -0.07 -0.30 0.229 transport and metabolism EcolC_2367 b1260 trpA tryptophan synthase, alpha subunit METABOLISM Amino acid -0.17 -0.19 0.17 0.14 0.736 transport and metabolism EcolC_2369 b1258 yciF predicted rubrerythrin/ferritin-like metal- POORLY Function -0.10 -0.15 -0.11 -0.16 0.598 binding protein CHARACTERIZ unknown ED EcolC_2370 b1257 yciE predicted rubrerythrin/ferritin-like metal- POORLY Function -0.02 -0.14 0.19 0.07 0.203 binding protein CHARACTERIZ unknown ED EcolC_2371 b1256 ompW outer membrane protein W CELLULAR Cell -2.05 -1.98 -0.08 -0.01 0.963 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2372 b1255 yciC inner membrane protein, UPF0259 family - - -0.04 0.11 -0.06 0.09 0.968 EcolC_2373 b1254 yciB predicted inner membrane protein CELLULAR Cell cycle 0.15 0.19 -0.11 -0.06 0.493 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2374 b1253 yciA acyl-CoA esterase METABOLISM Lipid 0.07 0.07 0.07 0.06 0.883 transport and metabolism EcolC_2375 b1252 tonB membrane spanning protein in TonB- CELLULAR Cell -0.12 0.09 0.03 0.23 0.340 ExbB-ExbD transport complex PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2376 b1251 yciI predicted enzyme POORLY Function -0.18 0.06 -0.17 0.07 0.092 CHARACTERIZ unknown ED EcolC_2377 b1250 kch voltage-gated potassium channel METABOLISM Inorganic ion -0.16 -0.18 -0.12 -0.14 0.732 transport and metabolism EcolC_2380 b1248 yciU conserved protein, UPF0263 family POORLY Function 0.13 0.08 0.05 -0.01 0.698 CHARACTERIZ unknown ED EcolC_2381 b1247 oppF oligopeptide transporter subunit METABOLISM Amino acid 0.15 0.73 0.16 0.75 0.036 transport and metabolism EcolC_2382 b1246 oppD oligopeptide transporter subunit METABOLISM Amino acid 0.38 0.66 -0.15 0.13 0.376 transport and metabolism EcolC_2383 b1245 oppC oligopeptide transporter subunit METABOLISM Amino acid 0.37 0.66 -0.33 -0.04 0.321 transport and metabolism EcolC_2384 b1244 oppB oligopeptide transporter subunit METABOLISM Amino acid 0.34 0.56 -0.22 0.01 0.176 transport and metabolism EcolC_2385 b1243 oppA oligopeptide transporter subunit METABOLISM Amino acid -0.42 0.41 -0.37 0.46 0.005 transport and metabolism EcolC_2386 b1242 ychE predicted inner membrane protein CELLULAR Intracellular 0.19 0.08 0.12 0.02 0.860 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_2387 b1241 adhE fused acetaldehyde-CoA METABOLISM Energy -0.53 -0.03 0.22 0.72 0.040 dehydrogenase/iron-dependent alcohol production dehydrogenase/pyruvate-formate lyase and deactivase conversion EcolC_2389 b1238 tdk /deoxyuridine kinase METABOLISM Nucleotide 0.14 -0.18 0.14 -0.18 0.072 transport and metabolism EcolC_2390 b1237 hns global DNA-binding transcriptional dual POORLY General 0.58 -0.26 -0.12 -0.96 0.014 regulator H-NS CHARACTERIZ function ED prediction EcolC_2391 b1236 galU glucose-1-phosphate uridylyltransferase CELLULAR Celll -0.01 0.19 -0.08 0.12 0.212 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2392 b1235 rssB response regulator binding RpoS to initiate CELLULAR Signal -0.59 -0.58 0.03 0.04 0.978 proteolysis by ClpXP; required for the PROCESSES transduction PcnB-degradosome interaction during AND mechanisms stationary phase SIGNALING EcolC_2393 b1234 rssA predicted , patatin-like POORLY General -0.09 0.30 0.18 0.56 0.388 family CHARACTERIZ function ED prediction EcolC_2394 b1233 ychJ conserved protein, UPF0225 family POORLY Functionl 0.30 0.36 -0.04 0.02 0.265 CHARACTERIZ unknown ED EcolC_2395 b1232 purU formyltetrahydrofolate hydrolase METABOLISM Nucleotide 0.68 0.68 -0.08 -0.07 0.907 transport and metabolism EcolC_2396 b1227 narI nitrate reductase 1, gamma (cytochrome METABOLISM Energy 0.01 0.02 0.16 0.17 0.874 b(NR)) subunit production and conversion EcolC_2397 b1226 narJ molybdenum-cofactor-assembly chaperone METABOLISM Energy 0.11 0.29 0.41 0.59 0.163 subunit (delta subunit) of nitrate reductase production 1 and conversion EcolC_2398 b1225 narH nitrate reductase 1, beta (Fe-S) subunit METABOLISM Energy 0.09 0.15 0.26 0.33 0.416 production and conversion EcolC_2399 b1224 narG nitrate reductase 1, alpha subunit METABOLISM Energy -0.35 -0.31 -0.12 -0.09 0.987 production and conversion EcolC_2400 b1223 narK nitrate/nitrite transporter METABOLISM Inorganic ion -0.02 0.00 0.27 0.29 0.561 transport and metabolism EcolC_2401 b1222 narX sensory histidine kinase in two-component CELLULAR Signal 0.17 0.07 0.37 0.27 0.147 regulatory system with NarL PROCESSES transduction AND mechanisms SIGNALING EcolC_2402 b1221 narL DNA-binding response regulator in two- CELLULAR Signal -0.86 -0.41 -0.05 0.41 0.120 component regulatory system with NarX PROCESSES transduction (or NarQ) AND mechanisms SIGNALING EcolC_2403 b1220 ychO predicted invasin - - 0.32 0.22 0.21 0.12 0.173 EcolC_2404 b1219 ychN conserved protein METABOLISM Inorganic ion -0.24 -0.13 -0.16 -0.05 0.449 transport and metabolism EcolC_2405 b1218 chaC cation transport regulator METABOLISM Inorganic ion 0.20 0.08 0.24 0.12 0.946 transport and metabolism EcolC_2406 b1217 chaB cation transport regulator POORLY General 0.08 0.17 0.34 0.43 0.557 CHARACTERIZ function ED prediction EcolC_2407 b1216 chaA calcium/sodium:proton antiporter METABOLISM Inorganicl ion -0.17 -0.26 -0.18 -0.27 0.528 transport and metabolism EcolC_2409 b4421 ldrB toxic polypeptide, small - - 0.02 0.35 0.22 0.55 0.111 EcolC_2410 b4419 ldrA toxic polypeptide, small - - 0.31 0.60 0.46 0.75 0.946 EcolC_2411 b1215 kdsA 3-deoxy-D-manno-octulosonate 8- CELLULAR Cell 0.17 0.08 -0.22 -0.31 0.620 phosphate synthase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2412 b1214 ychA conserved protein POORLY Function 0.32 0.25 0.14 0.07 0.562 CHARACTERIZ unknown ED EcolC_2413 b1213 ychQ predicted inner membrane protein, SIRB POORLY Function 0.03 -0.09 -0.02 -0.14 0.421 family CHARACTERIZ unknown ED EcolC_2414 b1212 prmC N5-glutamine methyltransferase, modifies INFORMATION Translation, -0.02 0.19 -0.10 0.11 0.256 release factors RF-1 and RF-2 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2415 b1211 prfA peptide chain release factor RF-1 INFORMATION Translation, 0.52 0.78 0.06 0.32 0.249 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2416 b1210 hemA glutamyl tRNA reductase METABOLISM Coenzyme 0.43 0.84 0.15 0.57 0.233 transport and metabolism EcolC_2417 b1209 lolB lipoprotein localization factor CELLULAR Cell 0.81 0.68 -0.10 -0.23 0.940 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2418 b1208 ispE 4-diphosphocytidyl-2-C-methylerythritol METABOLISM Lipid 0.49 0.65 0.31 0.47 0.252 kinase transport and metabolism EcolC_2419 b1207 prs phosphoribosylpyrophosphate synthase METABOLISM Nucleotide 0.31 0.42 0.08 0.19 0.322 transport and metabolism EcolC_2420 b1206 dauA C4-dicarboxylic acid transporter METABOLISM Inorganic ion 0.10 0.32 0.28 0.50 0.348 transport and metabolism EcolC_2421 b1205 ychH predicted inner membrane protein - - 0.36 0.25 0.32 0.21 0.937 EcolC_2422 b1204 pth peptidyl-tRNA hydrolase INFORMATION Translation, 0.35 0.29 -0.03 -0.09 0.519 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2423 b1203 ychF catalase inhibitor protein; ATPase, K+- INFORMATION Translation, 0.36 0.74 0.15 0.53 0.084 dependent, ribosome-associated STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2424 b1202 ycgV predicted adhesin CELLULAR Cell 0.00 0.06 0.30 0.35 0.817 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2425 b1201 dhaR DNA-binding transcription activator of the METABOLISM Secondary 0.28 0.08 0.02 -0.18 0.312 dhaKLM operon metabolites biosynthesis, transport and catabolism EcolC_2426 b1200 dhaK dihydroxyacetone kinase, PTS-dependent, METABOLISM Carbohydrate 0.47 1.47 -0.02 0.98 0.001 dihydroxyacetone-binding subunit transport and metabolism EcolC_2427 b1199 dhaL dihydroxyacetone kinase, C-terminal METABOLISM Carbohydrate 0.40 1.15 0.15 0.90 0.161 domain transport and metabolism EcolC_2428 b1198 dhaM fused predicted dihydroxyacetone-specific METABOLISM Carbohydrate 0.38 0.88 0.33 0.83 0.209 PTS enzymes: HPr component/EI transport and component metabolism EcolC_2429 b1197 treA periplasmic trehalase METABOLISM Carbohydrate 0.45 0.04 0.12 -0.29 0.116 transport and metabolism EcolC_2430 b1195 ymgE predicted inner membrane protein POORLY Function -0.12 -0.14 0.36 0.33 0.843 CHARACTERIZ unknown ED EcolC_2431 b1194 ycgR flagellar velocity braking protein, c-di- CELLULAR Cell -0.13 -0.18 -0.11 -0.16 0.947 GMP-regulated PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2432 b1193 emtA lytic murein endotransglycosylase E CELLULAR Cell -0.10 -0.15 -0.14 -0.20 0.376 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2433 b1192 ldcA murein tetrapeptide carboxypeptidase; LD- CELLULAR Defense 0.20 0.29 0.20 0.28 0.336 carboxypeptidase A PROCESSES mechanisms AND SIGNALING EcolC_2434 b1191 cvrA predicted cation/proton antiporter METABOLISM Inorganic ion 0.37 0.49 0.12 0.24 0.944 transport and metabolism EcolC_2435 b1190 dadX alanine racemase 2, PLP-binding CELLULAR Cell 0.77 -0.33 0.21 -0.89 0.008 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2436 b1189 dadA D-amino acid dehydrogenase METABOLISM Amino acid 0.75 -0.59 0.09 -1.26 0.000 transport and metabolism EcolC_2437 b1188 ycgB conserved protein POORLY Function -1.67 -2.46 0.65 -0.15 0.008 CHARACTERIZ unknown ED EcolC_2438 b1187 fadR DNA-binding transcriptional dual regulator INFORMATION Transcription -0.06 -0.14 -0.17 -0.25 0.729 of fatty acid metabolism STORAGE AND PROCESSING EcolC_2439 b1186 nhaB sodium:proton antiporter METABOLISM Inorganic ion -0.81 -0.55 -0.71 -0.45 0.338 transport and metabolism EcolC_2440 b1185 dsbB oxidoreductase that catalyzes reoxidation CELLULAR Posttranslatio -0.32 0.35 0.08 0.75 0.012 of DsbA protein disulfide isomerase I PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2441 b1184 umuC DNA polymerase V, subunit C INFORMATION Replication, -0.03 -0.01 -0.08 -0.05 0.921 STORAGE AND recombination PROCESSING and repair EcolC_2442 b1183 umuD DNA polymerase V, subunit D INFORMATION Transcription 0.05 -0.03 0.02 -0.06 0.552 STORAGE AND PROCESSING EcolC_2444 b1181 ycgN UPF0153 family cysteine cluster protein, POORLY Function -0.07 -0.36 0.01 -0.29 0.358 function unknown CHARACTERIZ unknown ED EcolC_2445 b1180 ycgM predicted isomerase/hydrolase METABOLISM Secondary -0.70 -0.53 -0.32 -0.16 0.360 metabolites biosynthesis, transport and catabolism EcolC_2447 b1178 pliG predicted protein - - 0.22 0.04 0.14 -0.04 0.808 EcolC_2448 b1177 ycgJ predicted protein - - 0.12 0.05 0.15 0.08 0.829 EcolC_2449 b1176 minC cell division inhibitor CELLULAR Cell cycle 0.25 -0.07 -0.20 -0.53 0.386 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2450 b1175 minD membrane ATPase of the MinC-MinD- CELLULAR Cell cycle 0.26 -0.02 -0.23 -0.51 0.102 MinE system PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2451 b1174 minE cell division topological specificity factor CELLULAR Cell cycle -0.04 -0.16 -0.12 -0.25 0.606 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2455 b1171 ymgD predicted protein - - 0.18 0.18 0.19 0.19 0.946 EcolC_2457 b4520 ymgF inner membrane division septum protein - - -0.15 -0.18 -0.08 -0.10 0.815 EcolC_2458 b1168 ycgG predicted membrane-anchored cyclic-di- CELLULAR Signal -0.28 -0.19 -0.66 -0.57 0.043 GMP phosphodiesterase PROCESSES transduction AND mechanisms SIGNALING EcolC_2459 b1167 ymgC predicted protein - - -0.10 -0.13 -0.23 -0.25 0.882 EcolC_2460 b1166 ariR RcsB connector protein for regulation of - - -0.19 -0.09 -0.12 -0.02 0.589 biofilm and acid-resistance EcolC_2461 b1165 ymgA RcsB connector protein for regulation of - - 0.02 -0.14 0.07 -0.09 0.335 biofilm EcolC_2462 b1164 ycgZ RcsB connector protein for regulation of - - -0.21 -0.13 -0.11 -0.04 0.816 biofilm and acid-resistance EcolC_2463 b1163 bluF anti-repressor for YcgE, blue light- CELLULAR Signal -0.32 -0.74 -0.37 -0.79 0.153 responsive; FAD-binding; has c-di-GMP PROCESSES transduction phosphodiesterase-like EAL domain, but AND mechanisms does not degrade c-di-GMP SIGNALING EcolC_2464 b1162 bluR repressor of blue light-responsive genes INFORMATION Transcription -0.12 -0.27 -0.10 -0.25 0.429 STORAGE AND PROCESSING EcolC_2465 b1161 ycgX predicted protein POORLY General -0.02 -0.14 -0.07 -0.19 0.356 CHARACTERIZ function ED prediction EcolC_2466 b1160 iraM RpoS stabilzer during Mg starvation, anti- - -l -0.19 -0.44 -0.28 -0.53 0.143 RssB factor EcolC_2467 b1136 icd e14 prophage; isocitrate dehydrogenase, METABOLISM Energy -0.09 -0.37 -0.38 -0.66 0.478 specific for NADP+ production and conversion EcolC_2467 b4519 icdC - - - 0.04 0.25 -0.20 0.01 0.838 EcolC_2468 b1135 rluE 23S rRNA pseudouridine(2457) synthase INFORMATION Translation, 0.35 0.27 0.11 0.02 0.690 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2469 b1134 nudJ bifunctional thiamin pyrimidine METABOLISM Nucleotide 1.26 0.91 0.00 -0.35 0.562 pyrophosphate hydrolase/ thiamin transport and pyrophosphate hydrolase metabolism EcolC_2470 b1133 mnmA tRNA(Gln,Lys,Glu) U34 2-thiouridylase, INFORMATION Translation, 0.37 0.49 -0.04 0.07 0.462 first step in mnm(5)-s(2)U34-tRNA STORAGE AND ribosomal synthesis PROCESSING structure and biogenesis EcolC_2471 b1132 hflD predicted lysogenization regulator POORLY General 0.21 0.46 -0.09 0.16 0.263 CHARACTERIZ function ED prediction EcolC_2472 b1131 purB adenylosuccinate lyase METABOLISM Nucleotidel -0.25 -0.01 -0.40 -0.16 0.020 transport and metabolism EcolC_2473 b1130 phoP DNA-binding response regulator in two- CELLULAR Signal 0.92 0.14 0.15 -0.62 0.023 component regulatory system with PhoQ PROCESSES transduction AND mechanisms SIGNALING EcolC_2474 b1129 phoQ sensory histidine kinase in two-component CELLULAR Signal 1.10 0.21 -0.01 -0.90 0.008 regulatory system with PhoP PROCESSES transduction AND mechanisms SIGNALING EcolC_2475 b1128 roxA 50S ribosomal protein L16 arginine POORLY Function 0.27 0.29 0.05 0.07 0.733 hydroxylase; 2-oxoglutarate CHARACTERIZ unknown ED EcolC_2476 b1127 pepT peptidase T METABOLISM Amino acid -0.40 -0.13 -0.28 0.00 0.176 transport and metabolism EcolC_2479 b1124 potC polyamine transporter subunit METABOLISM Amino acid -0.17 -0.32 -0.19 -0.33 0.731 transport and metabolism EcolC_2480 b1123 potD polyamine transporter subunit METABOLISM Amino acid -1.03 -0.52 -0.38 0.13 0.039 transport and metabolism EcolC_2482 b1119 nagK N-acetyl-D-glucosamine kinase INFORMATION Transcription 0.26 0.19 -0.22 -0.29 0.962 STORAGE AND PROCESSING EcolC_2483 b1118 lolE lipoprotein-releasing system CELLULAR Cell 0.34 0.13 -0.25 -0.46 0.184 transmembrane protein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2484 b1117 lolD outer membrane-specific lipoprotein CELLULAR Defense 0.42 0.29 0.05 -0.08 0.888 transporter subunit PROCESSES mechanisms AND SIGNALING EcolC_2485 b1116 lolC lipoprotein-releasing system CELLULAR Cell 0.26 0.42 0.21 0.36 0.450 transmembrane protein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2486 b1115 ycfT inner membrane protein POORLY Function -0.26 -0.05 -0.06 0.15 0.974 CHARACTERIZ unknown ED EcolC_2487 b1114 mfd transcription-repair coupling factor INFORMATION Replication, 0.08 -0.15 -0.28 -0.51 0.469 STORAGE AND recombination PROCESSING and repair EcolC_2488 b1113 ycfS L,D-transpeptidase linking Lpp to murein POORLY Function 0.30 -0.04 0.02 -0.32 0.160 CHARACTERIZ unknown ED EcolC_2489 b1112 bhsA biofilm, cell surface and signaling protein - - 0.61 0.55 0.18 0.13 0.792 EcolC_2490 b1111 ycfQ repressor for bhsA(ycfR) INFORMATION Transcription 0.60 0.71 0.00 0.11 0.779 STORAGE AND PROCESSING EcolC_2491 b1110 ycfJ predicted protein POORLY Function 0.54 0.58 0.10 0.14 0.899 CHARACTERIZ unknown ED EcolC_2492 b1109 ndh respiratory NADH dehydrogenase 2/cupric METABOLISM Energy 0.27 0.20 -0.05 -0.12 0.340 reductase production and conversion EcolC_2493 b1108 ycfP conserved protein POORLY General -0.88 -0.40 0.11 0.58 0.020 CHARACTERIZ function ED prediction EcolC_2494 b1107 nagZ beta N-acetyl-glucosaminidase METABOLISM Carbohydratel 0.11 0.08 -0.10 -0.13 0.639 transport and metabolism EcolC_2495 b1106 thiK thiamin kinase CELLULAR Cell 0.28 0.54 0.20 0.47 0.289 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2496 b1105 lpoB outer membrane lipoprotein POORLY General -0.30 -0.16 -0.13 0.00 0.175 CHARACTERIZ function ED prediction l EcolC_2497 b1104 ycfL predicted protein POORLY General -0.69 -0.43 -0.26 0.00 0.062 CHARACTERIZ function ED prediction EcolC_2498 b1103 hinT purine nucleoside phosphoramidase, dadA METABOLISM Nucleotidel -0.32 -0.17 -0.01 0.13 0.481 activator protein transport and metabolism EcolC_2499 b1102 fhuE ferric-rhodotorulic acid outer membrane METABOLISM Inorganic ion 0.08 -0.13 -0.05 -0.27 0.474 transporter transport and metabolism EcolC_2500 b1101 ptsG fused glucose-specific PTS enzymes: IIB METABOLISM Carbohydrate 1.47 1.75 0.17 0.46 0.549 component/IIC component transport and metabolism EcolC_2501 b1100 ycfH predicted DNAse INFORMATION Replication, 0.13 0.54 0.53 0.95 0.051 STORAGE AND recombination PROCESSING and repair EcolC_2502 b1099 holB DNA polymerase III, delta prime subunit INFORMATION Replication, 0.20 0.57 0.09 0.45 0.066 STORAGE AND recombination PROCESSING and repair EcolC_2503 b1098 tmk thymidylate kinase METABOLISM Nucleotide 0.16 0.55 0.11 0.51 0.106 transport and metabolism EcolC_2504 b1097 yceG septation protein, ampicillin sensitivity POORLY General 0.28 0.28 0.16 0.16 0.961 CHARACTERIZ function ED prediction EcolC_2505 b1096 pabC 4-amino-4-deoxychorismate lyase METABOLISM Aminol acid 0.36 0.38 0.26 0.28 0.758 component of para-aminobenzoate synthase transport and multienzyme complex metabolism EcolC_2506 b1095 fabF 3-oxoacyl-[acyl-carrier-protein] synthase METABOLISM Lipid -0.18 0.09 0.10 0.37 0.190 II transport and metabolism EcolC_2507 b1094 acpP acyl carrier protein (ACP) METABOLISM Lipid -0.43 0.02 0.11 0.56 0.005 transport and metabolism EcolC_2508 b1093 fabG 3-oxoacyl-[acyl-carrier-protein] reductase METABOLISM Lipid -0.27 0.26 -0.02 0.51 0.005 transport and metabolism EcolC_2509 b1092 fabD malonyl-CoA-[acyl-carrier-protein] METABOLISM Lipid -0.50 -0.04 -0.21 0.25 0.009 transacylase transport and metabolism EcolC_2510 b1091 fabH 3-oxoacyl-[acyl-carrier-protein] synthase METABOLISM Lipid -0.34 -0.33 -0.18 -0.17 0.878 III transport and metabolism EcolC_2511 b1090 plsX probable phosphate acyltransferase METABOLISM Lipid -0.34 -0.29 0.02 0.08 0.568 transport and metabolism EcolC_2512 b1089 rpmF 50S ribosomal subunit protein L32 INFORMATION Translation, -0.41 0.16 0.00 0.57 0.021 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2513 b1088 yceD conserved protein, DUF177 family POORLY General -0.92 -0.22 -0.07 0.63 0.005 CHARACTERIZ function ED prediction EcolC_2514 b1087 yceF Maf-like protein CELLULAR Celll cycle 0.32 0.46 0.21 0.35 0.952 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2515 b1086 rluC 23S rRNA pseudouridine(955,2504,2580) INFORMATION Translation, 0.14 0.10 0.05 0.01 0.715 synthase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2516 b1084 rne fused ribonucleaseE: INFORMATION Translation, 1.00 -0.26 -0.12 -1.38 0.030 /RNA-binding STORAGE AND ribosomal protein/RNA degradosome binding protein PROCESSING structure and biogenesis EcolC_2519 b1081 flgJ muramidase CELLULAR Cell -0.16 -0.13 -0.14 -0.12 0.389 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2520 b1080 flgI predicted flagellar basal body protein CELLULAR Cell motility -0.19 -0.10 -0.08 0.01 0.604 PROCESSES AND SIGNALING EcolC_2521 b1079 flgH flagellar protein of basal-body outer- CELLULAR Cell motility -0.58 0.05 -0.32 0.31 0.005 membrane L ring PROCESSES AND SIGNALING EcolC_2522 b1078 flgG flagellar component of cell-distal portion CELLULAR Cell motility -0.48 -0.09 -0.38 0.01 0.302 of basal-body rod PROCESSES AND SIGNALING EcolC_2523 b1077 flgF flagellar component of cell-proximal CELLULAR Cell motility -1.71 -0.14 -1.17 0.40 0.005 portion of basal-body rod PROCESSES AND SIGNALING EcolC_2524 b1076 flgE flagellar hook protein CELLULAR Cell motility -1.42 0.08 -1.17 0.33 0.036 PROCESSES AND SIGNALING EcolC_2525 b1075 flgD flagellar hook assembly protein CELLULAR Cell motility -1.87 -0.15 -1.49 0.24 0.001 PROCESSES AND SIGNALING EcolC_2526 b1074 flgC flagellar component of cell-proximal CELLULAR Cell motility -1.13 -0.03 -1.08 0.02 0.041 portion of basal-body rod PROCESSES AND SIGNALING EcolC_2527 b1073 flgB flagellar component of cell-proximal CELLULAR Cell motility -0.58 0.01 -0.50 0.08 0.023 portion of basal-body rod PROCESSES AND SIGNALING EcolC_2528 b1072 flgA assembly protein for flagellar basal-body CELLULAR Cell motility -0.15 0.10 -0.03 0.22 0.123 periplasmic P ring PROCESSES AND SIGNALING EcolC_2529 b1071 flgM anti-sigma factor for FliA (sigma 28) INFORMATION Transcription -0.15 0.07 0.03 0.25 0.251 STORAGE AND PROCESSING EcolC_2530 b1070 flgN export chaperone for FlgK and FlgL CELLULAR Cell motility 0.03 0.13 0.09 0.19 0.879 PROCESSES AND SIGNALING EcolC_2531 b1069 murJ probable peptidoglycan lipid II flippase POORLY General 0.07 0.36 0.12 0.41 0.212 required for murein synthesis CHARACTERIZ function ED prediction EcolC_2532 b1068 yceM predicted oxidoreductase with NAD(P)- POORLY Generall 0.14 0.35 0.00 0.21 0.138 binding Rossmann-fold domain CHARACTERIZ function ED prediction EcolC_2534 b1066 rimJ ribosomal-protein-S5-alanine N- INFORMATION Translation,l -0.10 -0.19 -0.16 -0.25 0.625 acetyltransferase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2535 b1065 mdtH multidrug resistance efflux transporter METABOLISM Carbohydrate 0.17 0.57 0.23 0.63 0.255 conferring overexpression resistance to transport and norfloxacin and enoxacin metabolism EcolC_2536 b1064 grxB glutaredoxin 2 (Grx2) CELLULAR Posttranslatio -0.47 0.00 0.05 0.52 0.102 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2537 b1063 yceB lipoprotein, DUF1439 family - - 0.17 0.18 0.05 0.06 0.940 EcolC_2538 b1062 pyrC dihydro-orotase METABOLISM Nucleotide -0.01 -0.33 -0.03 -0.34 0.033 transport and metabolism EcolC_2539 b1061 dinI DNA damage-inducible protein I - - 0.01 0.07 0.18 0.24 0.659 EcolC_2540 b1060 bssS biofilm regulator - - 0.05 -0.09 0.33 0.19 0.263 EcolC_2541 b1059 solA N-methyltryptophan oxidase, FAD-binding METABOLISM Amino acid 0.18 0.06 0.20 0.08 0.840 transport and metabolism EcolC_2542 b1058 yceO predicted protein - - -0.69 -0.57 -0.42 -0.29 0.413 EcolC_2543 b1057 yceJ predicted cytochrome b561 METABOLISM Energy -0.04 -0.14 -0.05 -0.16 0.372 production and conversion EcolC_2544 b1056 yceI secreted protein POORLY Function -0.10 -0.11 -0.14 -0.15 0.609 CHARACTERIZ unknown ED EcolC_2545 b1055 yceA predicted rhodanese-related POORLY General -0.04 0.02 0.02 0.07 0.809 sulfurtransferase CHARACTERIZ function ED prediction EcolC_2546 b1054 waaM lauryl-acyl carrier protein (ACP)- CELLULAR Celll 0.33 0.39 0.12 0.18 0.903 dependent acyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2547 b1053 mdtG predicted drug efflux system METABOLISM Carbohydrate 0.59 0.10 0.14 -0.35 0.325 transport and metabolism EcolC_2548 b1051 msyB multicopy suppressor of secY and secA - - -0.05 -0.12 -0.15 -0.22 0.707 EcolC_2550 b1049 opgH membrane glycosyltransferase CELLULAR Cell 0.40 0.30 0.05 -0.06 0.768 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2551 b1048 opgG osmoregulated periplasmic glucan (OPG) METABOLISM Inorganic ion 0.41 0.49 -0.17 -0.09 0.521 biosynthesis periplasmic protein transport and metabolism EcolC_2552 b1047 opgC membrane protein required for - - 0.11 0.05 0.07 0.00 0.613 succinylation of osmoregulated periplasmic glucans (OPGs) EcolC_2553 b1046 clsC stationary phase cardiolipin synthase 3 METABOLISM Lipid 0.21 0.14 0.16 0.09 0.797 transport and metabolism EcolC_2554 b1045 ymdB O-acetyl-ADP-ribose deacetylase; RNase POORLY General 0.13 0.21 0.14 0.22 0.321 III inhibitor during cold shock; putative CHARACTERIZ function cardiolipin synthase C regulatory subunit ED prediction EcolC_2555 b1044 ymdA predicted protein - -l -0.17 -0.28 -0.05 -0.16 0.416 EcolC_2556 b1043 csgC curli assembly protein - - -0.35 -0.29 -0.29 -0.23 0.756 EcolC_2557 b1042 csgA curlin subunit, amyloid curli fibers, cryptic - - -0.09 -0.07 0.04 0.06 0.742 EcolC_2558 b1041 csgB curlin nucleator protein, minor subunit in - - -0.21 -0.16 -0.19 -0.13 0.586 curli complex EcolC_2559 b1040 csgD DNA-binding transcriptional activator for CELLULAR Signal -0.02 -0.09 -0.07 -0.14 0.820 csgBA PROCESSES transduction AND mechanisms SIGNALING EcolC_2560 b1039 csgE curlin secretion specificity factor - - -0.11 -0.07 -0.06 -0.02 0.995 EcolC_2561 b1038 csgF outer membrane protein required for curli - - -0.16 -0.18 -0.12 -0.14 0.597 nucleation by CsgB EcolC_2562 b1037 csgG curli production assembly/transport outer CELLULAR Cell -0.08 -0.19 -0.06 -0.18 0.365 membrane lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2563 b1036 ycdZ DUF1097 family inner membrane protein - - 0.46 0.74 0.05 0.33 0.022 EcolC_2564 b1035 ycdY YcdX chaperone, redox enzyme maturation POORLY General -0.05 -0.11 0.04 -0.03 0.815 protein (REMP) required for swarming CHARACTERIZ function ED prediction EcolC_2565 b1034 ycdX alkaline phosphatase required for swarming METABOLISM Aminol acid -0.32 0.01 -0.04 0.30 0.246 transport and metabolism EcolC_2566 b1033 ghrA glyoxylate/hydroxypyruvate reductase A METABOLISM Coenzyme -0.29 -0.23 -0.12 -0.07 0.754 transport and metabolism EcolC_2567 b1029 ycdU predicted inner membrane protein - - -0.22 -0.10 -0.10 0.02 0.165 EcolC_2568 b1028 ymdE - - - 0.05 0.07 0.15 0.17 0.341 EcolC_2570 b0299 insF1 IS3 transposase B INFORMATION Replication, 0.13 -0.09 -0.14 -0.35 0.101 STORAGE AND recombination PROCESSING and repair EcolC_2571 b1025 ycdT diguanylate cyclase, membrane-anchored CELLULAR Signal -0.20 -0.22 -0.19 -0.22 0.761 PROCESSES transduction AND mechanisms SIGNALING EcolC_2572 b1024 pgaA biofilm adhesin polysaccharide PGA - - 0.17 0.00 -0.02 -0.19 0.145 secretin; OM porin; poly-beta-1,6-N-acetyl- D-glucosamine export protein EcolC_2573 b1023 pgaB poly-beta-1,6-N-acetyl-D-glucosamine METABOLISM Carbohydrate 0.06 0.03 0.17 0.14 0.436 (PGA) N-deacetylase; deacetylase required transport and for biofilm adhesin polysaccharide PGA metabolism export; outer membrane lipoprotein EcolC_2574 b1022 pgaC biofilm PGA synthase PgaCD, catalytic CELLULAR Cell -0.07 -0.12 0.09 0.04 0.594 subunit; poly-beta-1,6-N-acetyl-D- PROCESSES wall/membran glucosamine synthase; c-di-GMP- AND e/envelope stimulated activity and dimerization SIGNALING biogenesis EcolC_2575 b1021 pgaD biofilm PGA synthase PgaCD, regulatory - - -0.09 -0.27 0.17 -0.01 0.241 subunit; c-di-GMP-stimulated activity and dimerization EcolC_2576 b1020 phoH conserved protein with nucleoside CELLULAR Signal -1.34 -1.40 -1.30 -1.37 0.599 triphosphate hydrolase domain PROCESSES transduction AND mechanisms SIGNALING EcolC_2577 b1019 efeB deferrrochelatase, periplasmic METABOLISM Inorganic ion 0.20 0.06 0.07 -0.07 0.235 transport and metabolism EcolC_2578 b1018 efeO inactive ferrous ion transporter EfeUOB METABOLISM Inorganic ion 0.20 -0.02 0.11 -0.10 0.138 transport and metabolism EcolC_2579 b4490 efeU - - - 0.35 -0.06 0.14 -0.26 0.145 EcolC_2580 b1015 putP proline:sodium symporter METABOLISM Amino acid 0.84 0.00 0.10 -0.74 0.060 transport and metabolism EcolC_2581 b1014 putA fused DNA-binding transcriptional METABOLISM Energy 1.93 -0.03 0.18 -1.78 0.000 regulator/proline dehydrogenase/pyrroline- production 5-carboxylate dehydrogenase and conversion EcolC_2582 b1013 rutR DNA-binding transcriptional repressor for INFORMATION Transcription -0.02 -0.10 -0.05 -0.13 0.946 rut operon STORAGE AND PROCESSING EcolC_2583 b1012 rutA pyrimidine oxygenase, FMN-dependent METABOLISM Energy -0.01 -0.17 -0.05 -0.22 0.253 production and conversion EcolC_2584 b1011 rutB ureidoacrylate amidohydrolase METABOLISM Secondary 0.15 0.05 0.00 -0.10 0.742 metabolites biosynthesis, transport and catabolism EcolC_2585 b1010 rutC putative aminoacrylate deaminase, reactive INFORMATION Translation, -0.08 -0.01 0.07 0.14 0.409 intermediate detoxification STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2586 b1009 rutD putative aminoacrylate hydrolase, reactive POORLY General 0.22 -0.13 0.05 -0.30 0.152 intermediate detoxification CHARACTERIZ function ED prediction EcolC_2587 b1008 rutE malonic semialdehyde reductase METABOLISM Energyl 0.22 0.04 0.22 0.03 0.385 production and conversion EcolC_2588 b1007 rutF flavin:NADH reductase POORLY General -0.11 -0.05 0.05 0.11 0.617 CHARACTERIZ function ED prediction EcolC_2589 b1006 rutG pyrimidine permease METABOLISM Nucleotidel -0.29 -0.23 -0.30 -0.24 0.600 transport and metabolism EcolC_2590 b4518 ymdF conserved protein - - 0.63 0.39 0.66 0.41 0.078 EcolC_2591 b1004 wrbA NAD(P)H:quinone oxidoreductase POORLY General -2.48 -2.98 0.36 -0.14 0.227 CHARACTERIZ function ED prediction EcolC_2592 b1003 yccJ predicted protein - -l -2.76 -3.13 0.33 -0.04 0.349 EcolC_2593 b1002 agp glucose-1-phosphatase/inositol phosphatase - - 1.25 0.95 -0.04 -0.35 0.145 EcolC_2594 b1001 yccE predicted protein - - -0.09 -0.10 -0.22 -0.23 0.527 EcolC_2595 b1000 cbpA curved DNA-binding protein, DnaJ CELLULAR Posttranslatio -0.81 -1.13 0.33 0.02 0.163 homologue that functions as a co- PROCESSES nal chaperone of DnaK AND modification, SIGNALING protein turnover, chaperones EcolC_2596 b0999 cbpM modulator of CbpA co-chaperone - - -0.59 -0.82 0.21 -0.01 0.007 EcolC_2597 b0998 torD TorA-maturation chaperone POORLY General 0.11 0.24 0.33 0.46 0.798 CHARACTERIZ function ED prediction EcolC_2598 b0997 torA trimethylamine N-oxide (TMAO) reductase METABOLISM Energyl -0.01 0.09 0.02 0.12 0.625 I, catalytic subunit production and conversion EcolC_2599 b0996 torC trimethylamine N-oxide (TMAO) reductase METABOLISM Energy -0.20 -0.08 -0.07 0.06 0.374 I, cytochrome c-type subunit production and conversion EcolC_2600 b0995 torR DNA-binding response regulator in two- CELLULAR Signal 0.63 0.36 0.05 -0.23 0.312 component regulatory system with TorS PROCESSES transduction AND mechanisms SIGNALING EcolC_2601 b0994 torT periplasmic sensory protein associated with METABOLISM Carbohydrate 0.27 0.42 0.28 0.42 0.965 the TorRS two-component regulatory transport and system metabolism EcolC_2602 b0993 torS hybrid sensory histidine kinase in two- CELLULAR Signal 0.22 0.42 0.23 0.43 0.087 component regulatory system with TorR PROCESSES transduction AND mechanisms SIGNALING EcolC_2603 b0992 yccM predicted 4Fe-4S membrane protein METABOLISM Energy -0.03 0.04 0.18 0.25 0.600 production and conversion EcolC_2604 b4517 gnsA multicopy suppressor of secG(Cs) and - - 0.07 -0.09 0.28 0.11 0.244 fabA6(Ts); predicted regulator of phosphatidylethanolamine synthesis EcolC_2605 b0991 ymcE cold shock gene - - 0.19 0.14 0.07 0.02 0.516 EcolC_2607 b0990 cspG cold shock protein homolog, cold-inducible INFORMATION Transcription -0.45 -0.36 0.15 0.25 0.821 STORAGE AND PROCESSING EcolC_2608 b0989 cspH stress protein, member of the CspA-family INFORMATION Transcription -0.14 -0.01 0.35 0.48 0.978 STORAGE AND PROCESSING EcolC_2609 b0987 gfcA predicted protein - - 0.11 0.28 0.21 0.39 0.737 EcolC_2610 b0986 gfcB predicted outer membrane lipoprotein - - -0.07 -0.13 -0.01 -0.07 0.827 EcolC_2611 b0985 gfcC conserved protein - - -0.13 -0.09 -0.01 0.02 0.975 EcolC_2612 b0984 gfcD conserved protein - - -0.49 -0.63 -0.48 -0.62 0.543 EcolC_2613 b0983 gfcE lipoprotein required for formation of the O- CELLULAR Cell -0.10 -0.10 0.02 0.02 0.869 antigen capsule, predicted PROCESSES wall/membran exopolysaccharide export protein AND e/envelope SIGNALING biogenesis EcolC_2614 b0982 etp phosphotyrosine-protein phosphatase CELLULAR Signal -0.05 0.03 0.24 0.32 0.746 PROCESSES transduction AND mechanisms SIGNALING EcolC_2615 b0981 etk cryptic autophosphorylating protein CELLULAR Cell 0.02 0.10 -0.02 0.06 0.674 tyrosine kinase Etk PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2616 b0980 appA phosphoanhydride phosphorylase - - -0.02 -0.03 0.04 0.03 0.938 EcolC_2617 b0979 appB cytochrome bd-II oxidase, subunit II METABOLISM Energy -0.42 -0.28 -0.39 -0.25 0.972 production and conversion EcolC_2618 b0978 appC cytochrome bd-II oxidase, subunit I METABOLISM Energy -0.14 -0.02 -0.06 0.06 0.311 production and conversion EcolC_2619 b0977 hyaF protein involved in nickel incorporation - - 0.01 -0.06 -0.02 -0.09 0.532 into hydrogenase-1 proteins EcolC_2620 b0976 hyaE probable HyaA chaperone POORLY General 0.10 0.15 -0.01 0.04 0.820 CHARACTERIZ function ED prediction EcolC_2621 b0975 hyaD hydrogenase 1 maturation protease METABOLISM Energyl -0.01 -0.76 -0.60 -1.35 0.047 production and conversion EcolC_2622 b0974 hyaC hydrogenase 1, b-type cytochrome subunit METABOLISM Energy -0.24 0.02 -0.08 0.18 0.395 production and conversion EcolC_2624 b0256 insI1 IS30 transposase INFORMATION Replication, 0.20 0.28 0.06 0.13 0.521 STORAGE AND recombination PROCESSING and repair EcolC_2625 b0972 hyaA hydrogenase 1, small subunit METABOLISM Energy -0.08 0.08 0.34 0.51 0.526 production and conversion EcolC_2626 b0970 yccA HflBKC-binding inner membrane protein, POORLY General 0.82 -0.16 -0.26 -1.24 0.009 UPF0005 family CHARACTERIZ function ED prediction l EcolC_2627 b0969 tusE sulfurtransferase required for 2-thiolation METABOLISM Inorganic ion -0.35 -0.28 0.23 0.30 0.608 step of mnm(5)-s(2)U34-tRNA synthesis transport and metabolism EcolC_2628 b0968 yccX weak acylphosphatase METABOLISM Energy -0.74 -0.49 0.12 0.37 0.251 production and conversion EcolC_2629 b0967 rlmI 23S rRNA m(5)C1962 methyltransferase, POORLY General 0.30 0.45 0.29 0.44 0.974 SAM-dependent CHARACTERIZ function ED prediction EcolC_2630 b0966 hspQ heat shock protein involved in degradation POORLY Functionl 1.03 1.44 0.52 0.93 0.072 of mutant DnaA; hemimethylated oriC CHARACTERIZ unknown DNA-binding protein ED EcolC_2631 b0965 yccU predicted CoA-binding protein POORLY General -0.16 -0.12 0.15 0.18 0.603 CHARACTERIZ function ED prediction EcolC_2632 b0964 yccT conserved protein POORLY Functionl -0.25 -0.12 -0.02 0.11 0.818 CHARACTERIZ unknown ED EcolC_2633 b0963 mgsA methylglyoxal synthase METABOLISM Carbohydrate 0.33 0.36 -0.31 -0.28 0.702 transport and metabolism EcolC_2634 b0962 helD DNA helicase IV INFORMATION Replication, 0.36 0.32 0.20 0.17 0.902 STORAGE AND recombination PROCESSING and repair EcolC_2635 b0961 yccF inner membrane protein, DUF307 family POORLY Function -0.21 -0.30 -0.08 -0.17 0.608 CHARACTERIZ unknown ED EcolC_2636 b0960 yccS inner membrane protein POORLY Function -0.09 0.18 -0.06 0.21 0.261 CHARACTERIZ unknown ED EcolC_2637 b0959 sxy required for expression of CRP-S- INFORMATION Transcription 0.12 0.06 -0.02 -0.09 0.842 dependent promoters STORAGE AND PROCESSING EcolC_2638 b0958 sulA SOS cell division inhibitor CELLULAR Cell cycle -0.78 -0.56 0.12 0.33 0.072 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2639 b0957 ompA outer membrane protein A (3a;II*;G;d) CELLULAR Cell -1.37 -2.14 -0.21 -0.98 0.060 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2640 b0956 matP Ter macrodomain organizer matS-binding POORLY Function 0.57 0.33 0.17 -0.08 0.450 protein CHARACTERIZ unknown ED EcolC_2641 b0955 ycbZ predicted peptidase CELLULAR Posttranslatio 0.14 0.00 0.07 -0.07 0.279 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2642 b0954 fabA beta-hydroxydecanoyl thioester dehydrase METABOLISM Lipid 0.14 0.23 0.27 0.36 0.559 transport and metabolism EcolC_2643 b0953 rmf ribosome modulation factor INFORMATION Translation, 1.31 0.61 0.50 -0.20 0.118 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2644 b0952 ymbA conserved protein POORLY Function -0.01 0.17 0.01 0.19 0.220 CHARACTERIZ unknown ED EcolC_2645 b0951 pqiB paraquat-inducible protein B POORLY General -0.28 -0.49 -0.17 -0.39 0.665 CHARACTERIZ function ED prediction EcolC_2646 b0950 pqiA paraquat-inducible membrane protein A POORLY Functionl -0.17 -0.16 -0.02 -0.01 0.930 CHARACTERIZ unknown ED EcolC_2647 b0949 uup fused predicted transporter subunits of POORLY General -0.05 0.01 -0.08 -0.02 0.644 ABC superfamily: ATP-binding CHARACTERIZ function components ED prediction EcolC_2648 b0948 rlmL fused 23S rRNA m(2)G2445 and INFORMATION Replication,l 0.17 0.21 0.08 0.11 0.830 m(7)G2069 methyltransferase, SAM- STORAGE AND recombination dependent PROCESSING and repair EcolC_2649 b0947 ycbX predicted 2Fe-2S cluster-containing POORLY General -0.07 0.22 0.01 0.30 0.042 protein; 6-N-hydroxylaminopurine CHARACTERIZ function resistance protein ED prediction EcolC_2650 b0946 zapC FtsZ stabilizer - -l 0.10 0.20 0.02 0.12 0.944 EcolC_2651 b0945 pyrD dihydro-orotate oxidase, FMN-linked METABOLISM Nucleotide -0.25 -0.19 -0.20 -0.15 0.992 transport and metabolism EcolC_2652 b0944 ycbF predicted periplasmic pilini chaperone CELLULAR Cell motility 0.04 0.08 0.01 0.05 0.657 PROCESSES AND SIGNALING EcolC_2653 b0943 ycbV predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.14 -0.24 0.00 -0.10 0.969 PROCESSES AND SIGNALING EcolC_2654 b0942 ycbU predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.08 -0.05 -0.02 0.01 0.985 PROCESSES AND SIGNALING EcolC_2655 b0941 elfG predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.22 -0.38 -0.24 -0.39 0.526 PROCESSES AND SIGNALING EcolC_2657 b0939 elfD predicted periplasmic pilin chaperone CELLULAR Cell motility -0.21 -1.08 -0.32 -1.19 0.254 PROCESSES AND SIGNALING EcolC_2658 b0938 elfA predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.17 0.00 -0.12 0.05 0.398 PROCESSES AND SIGNALING EcolC_2659 b0937 ssuE NAD(P)H-dependent FMN reductase POORLY General 0.10 -0.02 0.02 -0.10 0.703 CHARACTERIZ function ED prediction EcolC_2660 b0936 ssuA aliphatic sulfonate binding protein, METABOLISM Inorganicl ion 0.01 -0.06 0.01 -0.06 0.929 SsuABC ABC transporter transport and metabolism EcolC_2661 b0935 ssuD alkanesulfonate monooxygenase, METABOLISM Energy 0.19 0.24 0.05 0.10 0.804 FMNH(2)-dependent production and conversion EcolC_2662 b0934 ssuC putative alkanesulfonate transporter METABOLISM Inorganic ion -0.10 -0.29 -0.13 -0.31 0.217 subunit transport and metabolism EcolC_2663 b0933 ssuB alkanesulfonate transporter subunit METABOLISM Inorganic ion 0.12 0.10 0.10 0.09 0.833 transport and metabolism EcolC_2664 b0932 pepN aminopeptidase N METABOLISM Amino acid 0.34 0.09 -0.07 -0.32 0.186 transport and metabolism EcolC_2665 b0931 pncB nicotinate phosphoribosyltransferase METABOLISM Coenzyme -0.15 -0.07 -0.07 0.01 0.885 transport and metabolism EcolC_2666 b0930 asnS asparaginyl tRNA synthetase INFORMATION Translation, -0.26 -0.08 -0.20 -0.02 0.279 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2667 b0929 ompF outer membrane porin 1a (Ia;b;F) CELLULAR Cell -3.53 -3.50 -1.06 -1.03 0.990 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2668 b0928 aspC aspartate aminotransferase, PLP-dependent METABOLISM Amino acid 0.15 0.26 -0.23 -0.13 0.669 transport and metabolism EcolC_2669 b0927 ycbL predicted metal-binding enzyme POORLY General 0.44 0.47 0.11 0.14 0.876 CHARACTERIZ function ED prediction EcolC_2670 b0926 ycbK conserved protein POORLY Functionl 1.70 0.85 0.15 -0.70 0.102 CHARACTERIZ unknown ED EcolC_2671 b0925 ycbB murein L,D-transpeptidase POORLY Function 0.10 -0.55 -0.25 -0.90 0.061 CHARACTERIZ unknown ED EcolC_2672 b0924 mukB chromosome condensin MukBEF, ATPase CELLULAR Cell cycle -0.60 -0.23 -0.45 -0.08 0.012 and DNA-binding subunit PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2673 b0923 mukE Chromosome condensin MukBEF, MukE CELLULAR Cell cycle -0.17 -0.31 -0.32 -0.46 0.995 localization factor PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2674 b0922 mukF chromosome condensin MukBEF, kleisin- CELLULAR Cell cycle 0.15 -0.14 -0.22 -0.51 0.292 like subunit, binds calcium PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2675 b0921 smtA predicted S-adenosyl-L-methionine- METABOLISM Coenzyme -0.16 0.00 -0.02 0.14 0.303 dependent methyltransferase transport and metabolism EcolC_2676 b0920 ycbC conserved protein, DUF218 superfamily POORLY Function -0.10 0.36 0.45 0.90 0.037 CHARACTERIZ unknown ED EcolC_2677 b0919 ycbJ conserved protein - - 0.04 1.28 -0.05 1.19 0.038 EcolC_2678 b0918 kdsB 3-deoxy-manno-octulosonate CELLULAR Cell -0.12 0.13 0.08 0.34 0.604 cytidylyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2679 b0917 ycaR peroxide and acid resistance protein, POORLY Function 0.10 0.29 0.05 0.24 0.183 UPF0434 family CHARACTERIZ unknown ED EcolC_2680 b0916 ycaQ conserved protein POORLY Function 0.35 -0.08 0.08 -0.35 0.113 CHARACTERIZ unknown ED EcolC_2681 b0915 lpxK lipid A 4'kinase CELLULAR Cell 0.13 0.08 0.05 0.00 0.987 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2682 b0914 msbA fused lipid transporter subunits of ABC CELLULAR Defense 0.19 0.13 0.07 0.02 0.619 superfamily: membrane component/ATP- PROCESSES mechanisms binding component AND SIGNALING EcolC_2683 b0913 ycaI inner membrane protein, ComEC family of POORLY General -0.27 -0.27 -0.30 -0.30 0.599 competence proteins CHARACTERIZ function ED prediction EcolC_2684 b0912 ihfB integration host factor (IHF), DNA-binding INFORMATION Replication,l 0.01 -0.15 -0.01 -0.18 0.944 protein, beta subunit STORAGE AND recombination PROCESSING and repair EcolC_2685 b0911 rpsA 30S ribosomal subunit protein S1 INFORMATION Translation, 0.51 0.20 -0.14 -0.45 0.173 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2686 b0910 cmk cytidylate kinase METABOLISM Nucleotide -0.05 -0.13 0.08 0.00 0.810 transport and metabolism EcolC_2687 b0909 ycaL predicted peptidase with chaperone CELLULAR Posttranslatio -0.28 -0.09 -0.17 0.02 0.126 function PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2688 b0908 aroA 5-enolpyruvylshikimate-3-phosphate METABOLISM Amino acid -0.28 -0.20 -0.23 -0.14 0.270 synthetase transport and metabolism EcolC_2689 b0907 serC 3-phosphoserine/phosphohydroxythreonine METABOLISM Coenzyme -0.40 -0.46 0.01 -0.05 0.540 aminotransferase transport and metabolism EcolC_2690 b0906 ycaP predicted inner membrane protein, POORLY Function 0.27 -0.05 0.13 -0.18 0.416 UPF0702 family CHARACTERIZ unknown ED EcolC_2691 b0905 ycaO ribosomal protein S12 POORLY Function -0.23 -0.05 -0.03 0.15 0.700 methylthiotransferase accessory factor CHARACTERIZ unknown ED EcolC_2692 b0904 focA formate channel METABOLISM Inorganic ion 0.63 -0.13 0.04 -0.73 0.017 transport and metabolism EcolC_2693 b0903 pflB pyruvate formate lyase I METABOLISM Energy -0.32 0.46 -0.11 0.67 0.027 production and conversion EcolC_2694 b0902 pflA pyruvate formate lyase activating enzyme 1 CELLULAR Posttranslatio -0.04 0.15 -0.03 0.17 0.066 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2695 b0901 ycaK conserved protein POORLY General -0.01 -0.01 0.04 0.04 0.547 CHARACTERIZ function ED prediction EcolC_2696 b0900 ycaN predicted DNA-binding transcriptional INFORMATION Transcriptionl -0.25 -0.19 0.00 0.05 0.543 regulator STORAGE AND PROCESSING EcolC_2697 b0899 ycaM predicted transporter METABOLISM Amino acid -0.11 -0.18 -0.02 -0.09 0.516 transport and metabolism EcolC_2698 b0898 ycaD predicted MFS-type transporter METABOLISM Carbohydrate -0.29 -0.25 -0.21 -0.16 0.650 transport and metabolism EcolC_2699 b0897 ycaC predicted hydrolase, isochorismatase METABOLISM Secondary -0.89 -0.26 0.26 0.89 0.010 family metabolites biosynthesis, transport and catabolism EcolC_2700 b0896 dmsC dimethyl sulfoxide reductase, anaerobic, POORLY General -1.68 -0.42 -0.09 1.17 0.003 subunit C CHARACTERIZ function ED prediction EcolC_2701 b0895 dmsB dimethyl sulfoxide reductase, anaerobic, METABOLISM Energyl -1.72 -0.45 -0.23 1.04 0.002 subunit B production and conversion EcolC_2702 b0894 dmsA dimethyl sulfoxide reductase, anaerobic, METABOLISM Energy -1.58 -0.37 -0.30 0.91 0.006 subunit A production and conversion EcolC_2703 b0893 serS seryl-tRNA synthetase, also charges INFORMATION Translation, -0.01 0.11 -0.01 0.10 0.650 selenocysteinyl-tRNA with serine STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2704 b0892 rarA DNA-dependent ATPase involved in INFORMATION Replication, -0.05 0.06 0.10 0.21 0.292 processing recombination intermediates at STORAGE AND recombination replication forks PROCESSING and repair EcolC_2705 b0891 lolA lipoprotein chaperone CELLULAR Cell -0.74 -0.35 -0.16 0.23 0.023 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2706 b0890 ftsK DNA translocase at septal ring sorting CELLULAR Cell cycle -0.37 -0.19 -0.06 0.12 0.125 daughter chromsomes PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_2707 b0889 lrp DNA-binding transcriptional dual INFORMATION Transcription 0.00 0.16 0.04 0.20 0.268 regulator, leucine-binding STORAGE AND PROCESSING EcolC_2708 b0888 trxB thioredoxin reductase, FAD/NAD(P)- CELLULAR Posttranslatio -0.07 -0.08 -0.20 -0.20 0.902 binding PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2709 b0887 cydD fused glutathione, cysteine exporter METABOLISM Energy 0.77 0.42 -0.15 -0.50 0.678 subunits of ABC superfamily: membrane production component/ATP-binding component and conversion EcolC_2710 b0886 cydC fused glutathione, cysteine exporter METABOLISM Energy 0.25 0.04 -0.03 -0.25 0.179 subunits of ABC superfamily: membrane production component/ATP-binding component and conversion EcolC_2711 b0885 aat leucyl/phenylalanyl-tRNA-protein CELLULAR Posttranslatio 0.07 0.01 0.03 -0.03 0.836 transferase PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2712 b0884 infA translation initiation factor IF-1 INFORMATION Translation, -0.24 0.16 -0.05 0.34 0.169 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2715 b0881 clpS regulatory protein for ClpA substrate POORLY Function -0.79 -0.65 0.22 0.35 0.517 specificity CHARACTERIZ unknown ED EcolC_2716 b0880 cspD inhibitor of DNA replication, cold shock INFORMATION Transcription 0.07 -0.84 0.22 -0.68 0.029 protein homolog STORAGE AND PROCESSING EcolC_2717 b0879 macB fused macrolide transporter subunits of CELLULAR Defense 0.12 0.35 0.20 0.43 0.102 ABC superfamily: ATP-binding PROCESSES mechanisms component/membrane component AND SIGNALING EcolC_2718 b0878 macA macrolide transporter subunit, membrane CELLULAR Cell -0.05 0.12 -0.11 0.07 0.865 fusion protein (MFP) component PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2719 b0877 ybjX conserved protein POORLY Function 0.53 -0.18 0.29 -0.42 0.005 CHARACTERIZ unknown ED EcolC_2720 b0876 ybjD conserved protein with nucleoside INFORMATION Replication, -0.27 -0.43 -0.07 -0.22 0.175 triphosphate hydrolase domain STORAGE AND recombination PROCESSING and repair EcolC_2721 b0875 aqpZ aquaporin Z METABOLISM Carbohydrate -0.35 -0.33 -0.46 -0.44 0.909 transport and metabolism EcolC_2722 b0874 ybjE predicted transporter POORLY Function -0.25 -0.52 -0.14 -0.41 0.375 CHARACTERIZ unknown ED EcolC_2723 b0873 hcp hybrid-cluster [4Fe-2S-2O] protein in METABOLISM Energy -0.16 -0.22 -0.27 -0.33 0.638 anaerobic terminal reductases production and conversion EcolC_2724 b0872 hcr HCP oxidoreductase, NADH-dependent METABOLISM Energy -0.11 -0.05 -0.01 0.05 0.748 production and conversion EcolC_2725 b0871 poxB pyruvate dehydrogenase (pyruvate METABOLISM Amino acid 0.18 -0.06 0.08 -0.16 0.023 oxidase), thiamin-dependent, FAD-binding transport and metabolism EcolC_2726 b0870 ltaE L-allo-threonine aldolase, PLP-dependent METABOLISM Amino acid -0.49 -0.44 -0.28 -0.23 0.599 transport and metabolism EcolC_2727 b0869 ybjT conserved protein with NAD(P)-binding CELLULAR Cell 0.14 0.08 -0.01 -0.07 0.614 Rossmann-fold domain PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2728 b0868 ybjS predicted NAD(P)H-binding CELLULAR Cell 0.19 -0.06 0.22 -0.02 0.332 oxidoreductase with NAD(P)-binding PROCESSES wall/membran Rossmann-fold domain AND e/envelope SIGNALING biogenesis EcolC_2729 b0867 amiD 1,6-anhydro-N-acetylmuramyl-L-alanine CELLULAR Defense 0.09 -0.10 -0.02 -0.22 0.046 amidase, Zn-dependent; OM lipoprotein PROCESSES mechanisms AND SIGNALING EcolC_2730 b0866 ybjQ conserved protein, UPF0145 family POORLY Function 0.09 -0.27 0.10 -0.25 0.025 CHARACTERIZ unknown ED EcolC_2731 b0865 ybjP lipoprotein - - -0.33 -0.82 -0.08 -0.57 0.003 EcolC_2732 b0864 artP arginine transporter subunit METABOLISM Amino acid -0.32 -0.70 -0.20 -0.58 0.005 transport and metabolism EcolC_2733 b0863 artI arginine transporter subunit METABOLISM Amino acid -0.73 -0.71 -0.41 -0.39 0.548 transport and metabolism EcolC_2734 b0862 artQ arginine transporter subunit METABOLISM Amino acid -0.22 -0.53 -0.23 -0.53 0.271 transport and metabolism EcolC_2735 b0861 artM arginine transporter subunit METABOLISM Amino acid -0.16 -0.29 -0.18 -0.31 0.331 transport and metabolism EcolC_2736 b0860 artJ arginine binding protein, periplasmic METABOLISM Amino acid -0.20 -0.38 -0.13 -0.31 0.540 transport and metabolism EcolC_2737 b0859 rlmC 23S rRNA m(5)U747 methyltransferase, INFORMATION Translation, 0.08 0.10 -0.09 -0.07 0.893 SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2738 b0858 ybjO inner membrane protein, DUF2593 family - - 0.15 0.01 0.07 -0.07 0.955 EcolC_2739 b0857 potI putrescine transporter subunit: membrane METABOLISM Amino acid -0.46 -0.60 -0.41 -0.55 0.600 component of ABC superfamily transport and metabolism EcolC_2740 b0856 potH putrescine transporter subunit: membrane METABOLISM Amino acid 0.36 0.41 0.08 0.13 0.758 component of ABC superfamily transport and metabolism EcolC_2741 b0855 potG putrescine transporter subunit: ATP- METABOLISM Amino acid -0.23 -0.25 -0.29 -0.31 0.901 binding component of ABC superfamily transport and metabolism EcolC_2742 b0854 potF putrescine transporter subunit: periplasmic- METABOLISM Amino acid -0.05 -0.17 -0.02 -0.14 0.376 binding component of ABC superfamily transport and metabolism EcolC_2743 b0853 ybjN negative regulator of motility; multicopy - - -0.12 -0.35 -0.09 -0.32 0.258 suppressor of coaA(Ts) EcolC_2744 b0852 rimK ribosomal protein S6 modification protein METABOLISM Coenzyme 0.70 -0.37 -0.35 -1.42 0.011 transport and metabolism EcolC_2745 b0851 nfsA nitroreductase A, NADPH-dependent, METABOLISM Energy 1.93 0.02 -0.09 -2.01 0.004 FMN-dependent production and conversion EcolC_2746 b0850 ybjC conserved protein, DUF1418 family - - 2.46 0.14 -0.26 -2.59 0.001 EcolC_2747 b0849 grxA glutaredoxin 1, redox coenzyme for CELLULAR Posttranslatio -0.16 -0.09 -0.24 -0.17 0.177 ribonucleotide reductase (RNR1a) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2748 b0848 ybjM inner membrane protein - - -0.17 -0.14 -0.10 -0.06 0.543 EcolC_2749 b0847 ybjL predicted transporter POORLY General 0.34 0.26 0.10 0.02 0.984 CHARACTERIZ function ED prediction EcolC_2750 - - prophage P2 OGR-like protein - -l 0.57 0.20 0.54 0.17 0.142 EcolC_2762 - - putative phage tail protein POORLY General 0.02 0.09 0.10 0.16 0.603 CHARACTERIZ function ED prediction EcolC_2763 - - phage baseplate assembly protein POORLY Generall 0.32 0.20 0.52 0.40 0.521 CHARACTERIZ function ED prediction EcolC_2764 - - phage baseplate assembly protein POORLY Generall -0.05 -0.08 -0.04 -0.07 0.876 CHARACTERIZ function ED prediction EcolC_2769 - - putative Regulatory protein - -l -0.03 0.01 -0.14 -0.10 0.391 EcolC_2776 - - putative capsid scaffolding protein - - -0.03 0.01 -0.12 -0.08 0.690 EcolC_2777 - - Terminase, ATPase subunit POORLY Function 0.05 0.01 -0.08 -0.12 0.940 CHARACTERIZ unknown ED EcolC_2778 - - putative capsid portal protein POORLY General 0.44 0.60 0.25 0.41 0.284 CHARACTERIZ function ED prediction EcolC_2782 - - Prophage protein - -l 0.40 0.52 0.50 0.61 0.372 EcolC_2784 - - putative replication protein for prophage - - 0.10 -0.02 0.04 -0.08 0.846 EcolC_2787 - - hypothetical protein CELLULAR Signal 0.03 0.10 0.11 0.17 0.462 PROCESSES transduction AND mechanisms SIGNALING EcolC_2788 - - hypothetical protein - - -0.01 0.15 0.16 0.33 0.999 EcolC_2789 - - hypothetical protein - - 0.07 -0.19 0.01 -0.24 0.528 EcolC_2791 - - hypothetical protein - - 0.03 0.02 0.22 0.21 0.817 EcolC_2792 - - hypothetical protein - - 0.07 0.15 0.25 0.32 0.999 EcolC_2795 - - for prophage INFORMATION Replication, -0.02 -0.08 0.07 0.01 0.907 STORAGE AND recombination PROCESSING and repair EcolC_2796 b0846 rcdA transcriptional regulator of csgD and ybiJI; POORLY Function 0.13 -0.03 0.15 -0.01 0.384 autoregulator CHARACTERIZ unknown ED EcolC_2797 b0845 ybjJ predicted transporter METABOLISM Carbohydrate 0.06 -0.24 -0.11 -0.41 0.143 transport and metabolism EcolC_2798 b0844 ybjI FMN and erythrose-4-P phosphatase POORLY General -0.07 -0.45 -0.14 -0.51 0.317 CHARACTERIZ function ED prediction EcolC_2799 b0843 ybjH predicted protein - -l -0.01 -0.19 -0.08 -0.26 0.676 EcolC_2800 b0842 mdfA multidrug efflux system protein METABOLISM Carbohydrate -0.47 -0.43 -0.36 -0.32 0.981 transport and metabolism EcolC_2801 b0841 ybjG undecaprenyl pyrophosphate phosphatase METABOLISM Lipid 0.45 -0.38 -0.25 -1.08 0.383 transport and metabolism EcolC_2802 b0840 deoR DNA-binding transcriptional repressor INFORMATION Transcription 0.17 -0.02 0.31 0.12 0.538 STORAGE AND PROCESSING EcolC_2803 b0839 dacC D-alanyl-D-alanine carboxypeptidase CELLULAR Cell -0.04 -0.49 0.11 -0.35 0.010 (penicillin-binding protein 6a) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2804 b0838 gstB glutathione S-transferase CELLULAR Posttranslatio -0.25 -0.09 0.04 0.20 0.625 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2805 b0837 yliI soluble aldose sugar dehydrogenase METABOLISM Carbohydrate 0.28 0.21 0.27 0.20 0.720 transport and metabolism EcolC_2806 b0836 bssR repressor of biofilm formation by indole - - -0.39 -0.37 0.35 0.37 0.718 transport regulation EcolC_2807 b0835 rimO ribosomal protein S12 INFORMATION Translation, -0.41 -0.40 -0.22 -0.21 0.937 methylthiotransferase; radical SAM STORAGE AND ribosomal superfamily PROCESSING structure and biogenesis EcolC_2810 b0834 yliF predicted membrane-anchored diguanylate CELLULAR Signal -0.23 -0.14 -0.21 -0.12 0.729 cyclase PROCESSES transduction AND mechanisms SIGNALING EcolC_2812 b0832 gsiD glutathione transporter, permease METABOLISM Amino acid -0.25 -0.19 -0.27 -0.21 0.979 component, ABC superfamily transport and metabolism EcolC_2813 b0831 gsiC glutathione transporter, permease METABOLISM Amino acid -0.54 -0.55 -0.32 -0.32 0.653 component, ABC superfamily transport and metabolism EcolC_2814 b0830 gsiB glutathione periplasmic binding protein, METABOLISM Amino acid -0.32 -0.17 -0.11 0.03 0.929 ABC superfamily transporter transport and metabolism EcolC_2815 b0829 gsiA glutathione transporter ATP-binding POORLY General -0.69 -0.79 -0.17 -0.27 0.748 protein, ABC superfamily CHARACTERIZ function ED prediction EcolC_2816 b0828 iaaA Isoaspartyl peptidase METABOLISM Aminol acid -0.87 -0.88 -0.20 -0.22 0.596 transport and metabolism EcolC_2817 b0827 moeA molybdopterin molybdenumtransferase; METABOLISM Coenzyme 0.07 0.09 -0.04 -0.02 0.946 molybdopterin biosynthesis protein transport and metabolism EcolC_2818 b0826 moeB molybdopterin synthase sulfurylase METABOLISM Coenzyme 0.10 0.28 -0.15 0.03 0.212 transport and metabolism EcolC_2819 b0825 fsaA fructose-6-phosphate aldolase 1 METABOLISM Carbohydrate -0.15 0.15 -0.10 0.20 0.574 transport and metabolism EcolC_2820 b0824 ybiY predicted pyruvate formate lyase activating CELLULAR Posttranslatio -0.15 -0.16 -0.19 -0.19 0.724 enzyme PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2823 b0820 ybiT fused predicted transporter subunits of POORLY General -0.10 0.13 -0.11 0.12 0.308 ABC superfamily: ATP-binding CHARACTERIZ function components ED prediction EcolC_2824 b0819 ybiS L,D-transpeptidase linking Lpp to murein POORLY Functionl -0.05 -0.12 -0.10 -0.17 0.653 CHARACTERIZ unknown ED EcolC_2825 b0818 ybiR predicted transporter METABOLISM Inorganic ion 0.08 -0.15 -0.12 -0.35 0.338 transport and metabolism EcolC_2826 b0817 mntR DNA-binding transcriptional regulator of INFORMATION Transcription 0.29 -0.05 -0.10 -0.43 0.038 mntH STORAGE AND PROCESSING EcolC_2828 b0815 ybiP predicted hydrolase, inner membrane POORLY General 0.13 -0.14 -0.17 -0.44 0.184 CHARACTERIZ function ED prediction EcolC_2829 b0814 ompX outer membrane protein X CELLULAR Celll 0.33 0.38 -0.52 -0.47 0.602 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2830 b0813 rhtA threonine and homoserine efflux system POORLY General -0.07 0.01 -0.11 -0.02 0.862 CHARACTERIZ function ED prediction EcolC_2831 b0812 dps Fe-binding and storage protein; stress- METABOLISM Inorganicl ion -1.26 -2.07 0.28 -0.53 0.044 inducible DNA-binding protetin transport and metabolism EcolC_2832 b0811 glnH glutamine transporter subunit METABOLISM Amino acid 0.14 -0.67 -0.64 -1.45 0.024 transport and metabolism EcolC_2833 b0810 glnP glutamine transporter subunit METABOLISM Amino acid 0.32 0.17 -0.02 -0.17 0.284 transport and metabolism EcolC_2834 b0809 glnQ glutamine transporter subunit METABOLISM Amino acid 0.31 -0.15 -0.09 -0.55 0.001 transport and metabolism EcolC_2835 b0808 ybiO mechanosensitive channel protein, CELLULAR Cell 0.06 -0.13 -0.04 -0.23 0.047 intermediate conductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2836 b0807 rlmF 23S rRNA m(6)A1618 methyltransferase, POORLY General 0.15 0.09 -0.07 -0.12 0.827 SAM-dependent CHARACTERIZ function ED prediction l EcolC_2838 b0805 fiu catecholate siderophore receptor Fiu METABOLISM Inorganic ion -0.18 -0.15 -0.19 -0.16 0.654 transport and metabolism EcolC_2839 b0804 ybiX conserved protein, Fe(II)-dependent POORLY Function -0.13 0.08 0.14 0.36 0.053 oxygenase superfamily CHARACTERIZ unknown ED EcolC_2840 b0803 ybiI DksA-type zinc finger protein CELLULAR Signal -0.03 0.00 0.06 0.10 0.856 PROCESSES transduction AND mechanisms SIGNALING EcolC_2841 b0802 ybiJ predicted protein - - -0.19 0.07 0.09 0.35 0.136 EcolC_2842 b0801 ybiC predicted dehydrogenase METABOLISM Energy -0.20 -0.28 -0.16 -0.24 0.425 production and conversion EcolC_2843 b0800 ybiB predicted family 3 glycosyltransferase METABOLISM Amino acid -0.35 -0.07 0.06 0.34 0.194 transport and metabolism EcolC_2844 b0799 dinG ATP-dependent DNA helicase INFORMATION Transcription 1.30 1.37 -0.34 -0.27 0.795 STORAGE AND PROCESSING EcolC_2845 b0798 ybiA conserved protein, DUF1768 family POORLY Function 0.92 1.41 0.08 0.58 0.020 CHARACTERIZ unknown ED EcolC_2846 b0797 rhlE ATP-dependent RNA helicase INFORMATION Replication, -0.64 -0.48 -0.17 -0.01 0.206 STORAGE AND recombination PROCESSING and repair EcolC_2847 b0796 ybiH predicted DNA-binding transcriptional - - 0.91 -0.10 0.67 -0.34 0.007 regulator EcolC_2848 b0795 ybhG predicted membrane fusion protein (MFP) CELLULAR Defense 1.97 -0.10 1.23 -0.84 0.001 component of efflux pump, membrane PROCESSES mechanisms anchor AND SIGNALING EcolC_2849 b0794 ybhF fused predicted transporter subunits of CELLULAR Defense 2.23 0.06 1.49 -0.68 0.001 ABC superfamily: ATP-binding PROCESSES mechanisms components AND SIGNALING EcolC_2850 b0793 ybhS predicted transporter subunit: membrane CELLULAR Defense 1.74 0.20 0.90 -0.64 0.001 component of ABC superfamily PROCESSES mechanisms AND SIGNALING EcolC_2851 b0792 ybhR predicted transporter subunit: membrane CELLULAR Defense 0.46 0.47 0.49 0.50 0.979 component of ABC superfamily PROCESSES mechanisms AND SIGNALING EcolC_2852 b0791 ybhQ inner membrane protein - - 0.15 -0.10 0.25 0.00 0.025 EcolC_2853 b0790 ybhP conserved protein, POORLY General -0.14 -0.33 0.09 -0.10 0.444 endo/exonuclease/phosphatase family CHARACTERIZ function PFAM PF03372 ED prediction EcolC_2854 b0789 clsB cardiolipin synthase 2 METABOLISM Lipidl 0.02 -0.16 0.16 -0.01 0.135 transport and metabolism EcolC_2855 b0788 ybhN conserved inner membrane protein POORLY Function 0.01 -0.01 -0.02 -0.04 0.571 CHARACTERIZ unknown ED EcolC_2856 b0787 ybhM inner membrane protein, UPF0005 family POORLY General -0.17 0.04 -0.06 0.16 0.177 CHARACTERIZ function ED prediction EcolC_2857 b0786 ybhL inner membrane protein, UPF0005 family POORLY Generall -0.64 -1.05 0.35 -0.06 0.177 CHARACTERIZ function ED prediction l EcolC_2858 b0785 moaE molybdopterin synthase, large subunit METABOLISM Coenzyme 0.09 0.32 0.15 0.38 0.112 transport and metabolism EcolC_2859 b0784 moaD molybdopterin synthase, small subunit METABOLISM Coenzyme 0.32 0.46 0.07 0.21 0.483 transport and metabolism EcolC_2860 b0783 moaC molybdopterin biosynthesis, protein C METABOLISM Coenzyme 0.16 0.41 0.09 0.34 0.295 transport and metabolism EcolC_2861 b0782 moaB molybdopterin biosynthesis protein B METABOLISM Coenzyme -0.13 0.17 -0.18 0.11 0.170 transport and metabolism EcolC_2862 b0781 moaA molybdopterin biosynthesis protein A METABOLISM Coenzyme 0.07 0.24 0.02 0.18 0.521 transport and metabolism EcolC_2863 b0780 ybhK predicted transferase with NAD(P)-binding POORLY Function 0.10 -0.07 -0.22 -0.39 0.292 Rossmann-fold domain CHARACTERIZ unknown ED EcolC_2864 b0779 uvrB excinulease of nucleotide excision repair, INFORMATION Replication, 0.74 0.78 -0.08 -0.04 0.614 DNA damage recognition component STORAGE AND recombination PROCESSING and repair EcolC_2865 b0778 bioD dethiobiotin synthetase METABOLISM Coenzyme -0.06 -0.18 -0.30 -0.41 0.293 transport and metabolism EcolC_2866 b0777 bioC malonyl-CoA methyltransferase, SAM- METABOLISM Coenzyme -0.24 -0.26 -0.17 -0.18 0.490 dependent transport and metabolism EcolC_2867 b0776 bioF 8-amino-7-oxononanoate synthase METABOLISM Coenzyme -0.21 -0.26 -0.21 -0.26 0.736 transport and metabolism EcolC_2868 b0775 bioB biotin synthase METABOLISM Coenzyme -0.10 -0.28 -0.20 -0.38 0.280 transport and metabolism EcolC_2870 b0773 ybhB kinase inhibitor homolog, UPF0098 family POORLY General 0.10 0.29 0.03 0.22 0.284 CHARACTERIZ function ED prediction EcolC_2877 b0539 exoD - - -l 0.18 0.08 0.15 0.04 0.406 EcolC_2880 - - hypothetical protein - - -0.08 0.05 0.23 0.36 0.741 EcolC_2889 - - integrase INFORMATION Replication, 0.09 0.03 0.38 0.32 0.679 STORAGE AND recombination PROCESSING and repair EcolC_2890 b0772 ybhC acyl-CoA thioesterase, lipoprotein METABOLISM Carbohydrate 0.12 -0.02 0.17 0.02 0.913 transport and metabolism EcolC_2891 b0771 ybhJ predicted hydratase METABOLISM Energy 0.00 0.29 0.07 0.37 0.061 production and conversion EcolC_2892 b0770 ybhI predicted transporter METABOLISM Inorganic ion -0.06 0.07 -0.14 -0.01 0.431 transport and metabolism EcolC_2893 b0769 ybhH conserved protein POORLY Function -0.11 -0.21 -0.26 -0.36 0.947 CHARACTERIZ unknown ED EcolC_2894 b0768 ybhD predicted DNA-binding transcriptional INFORMATION Transcription -0.09 -0.22 -0.12 -0.26 0.742 regulator STORAGE AND PROCESSING EcolC_2895 b0767 pgl 6-phosphogluconolactonase METABOLISM Carbohydrate -0.69 -0.65 -0.36 -0.32 0.884 transport and metabolism EcolC_2896 b0766 ybhA pyridoxal phosphate (PLP) phosphatase POORLY General -0.04 0.12 -0.18 -0.02 0.414 CHARACTERIZ function ED prediction EcolC_2897 b0765 modC molybdate transporter subunit METABOLISM Inorganicl ion 0.05 -0.18 0.11 -0.13 0.288 transport and metabolism EcolC_2898 b0764 modB molybdate transporter subunit METABOLISM Inorganic ion -0.13 -0.08 -0.11 -0.06 0.816 transport and metabolism EcolC_2899 b0763 modA molybdate transporter subunit METABOLISM Inorganic ion -0.22 -0.50 0.23 -0.05 0.335 transport and metabolism EcolC_2900 b0762 acrZ AcrAB-TolC efflux pump accessory - - 0.02 0.18 -0.02 0.14 0.296 protein, membrane-associated EcolC_2901 b0761 modE DNA-binding transcriptional repressor for POORLY General 0.34 0.33 -0.18 -0.20 0.956 the molybdenum transport operon CHARACTERIZ function modABC ED prediction EcolC_2902 b0760 modF fused molybdate transporter subunits of METABOLISM Inorganicl ion -0.21 -0.47 -0.38 -0.63 0.138 ABC superfamily: ATP-binding transport and components metabolism EcolC_2903 b0759 galE UDP-galactose-4-epimerase CELLULAR Cell -0.19 0.01 -0.25 -0.04 0.236 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2904 b0758 galT galactose-1-phosphate uridylyltransferase METABOLISM Energy -0.09 -0.24 -0.26 -0.41 0.727 production and conversion EcolC_2905 b0757 galK METABOLISM Carbohydrate -0.08 -0.06 -0.07 -0.05 0.745 transport and metabolism EcolC_2906 b0756 galM galactose-1-epimerase (mutarotase) METABOLISM Carbohydrate -0.31 -0.32 -0.28 -0.29 0.874 transport and metabolism EcolC_2907 b0755 gpmA phosphoglyceromutase 1 METABOLISM Carbohydrate -0.15 -0.23 -0.18 -0.25 0.797 transport and metabolism EcolC_2908 b0754 aroG 3-deoxy-D-arabino-heptulosonate-7- METABOLISM Amino acid -0.49 -0.63 -0.10 -0.24 0.492 phosphate synthase, phenylalanine transport and repressible metabolism EcolC_2909 b0753 ybgS conserved protein - - 0.04 -0.18 0.08 -0.14 0.108 EcolC_2910 b0752 zitB zinc efflux system METABOLISM Inorganic ion -0.06 -0.16 0.12 0.02 0.658 transport and metabolism EcolC_2911 b0751 pnuC nicotinamide riboside transporter METABOLISM Coenzyme -0.14 0.21 0.01 0.35 0.382 transport and metabolism EcolC_2912 b0750 nadA quinolinate synthase, subunit A METABOLISM Coenzyme 0.25 0.16 0.02 -0.07 0.937 transport and metabolism EcolC_2913 b0742 ybgF periplasmic TolA-binding protein POORLY Function -0.32 -0.54 -0.20 -0.41 0.795 CHARACTERIZ unknown ED EcolC_2914 b0741 pal peptidoglycan-associated outer membrane CELLULAR Cell -0.66 -0.67 -0.19 -0.20 0.650 lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2915 b0740 tolB periplasmic protein CELLULAR Intracellular -0.06 -0.42 -0.18 -0.55 0.091 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_2916 b0739 tolA membrane anchored protein in TolA-TolQ- CELLULAR Cell -0.14 0.12 0.09 0.34 0.995 TolR complex PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2917 b0738 tolR membrane spanning protein in TolA-TolQ- CELLULAR Intracellular 0.17 0.12 0.03 -0.03 0.937 TolR complex PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_2918 b0737 tolQ membrane spanning protein in TolA-TolQ- CELLULAR Intracellular -0.12 -0.03 -0.06 0.03 0.469 TolR complex PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_2919 b0736 ybgC acyl-CoA thioesterase, involved in POORLY General 0.01 0.17 -0.02 0.14 0.355 phospholipid metabolism CHARACTERIZ function ED prediction EcolC_2920 b0735 ybgE conserved protein POORLY Functionl -0.16 0.11 -0.10 0.17 0.398 CHARACTERIZ unknown ED EcolC_2921 b4515 ybgT conserved protein POORLY Function -1.24 -0.37 -0.06 0.82 0.220 CHARACTERIZ unknown ED EcolC_2922 b0734 cydB cytochrome d terminal oxidase, subunit II METABOLISM Energy -0.40 0.16 -0.20 0.36 0.143 production and conversion EcolC_2923 b0733 cydA cytochrome d terminal oxidase, subunit I METABOLISM Energy 0.49 0.35 0.05 -0.09 0.047 production and conversion EcolC_2924 b0732 mngB alpha-mannosidase METABOLISM Carbohydrate 0.04 -0.06 0.09 -0.01 0.810 transport and metabolism EcolC_2925 b0731 mngA fused 2-O-a-mannosyl-D-glycerate specific METABOLISM Carbohydrate -0.16 -0.28 -0.23 -0.35 0.665 PTS enzymes: IIA component/IIB transport and component/IIC component metabolism EcolC_2926 b0730 mngR DNA-binding transcriptional dual INFORMATION Transcription -0.06 0.00 -0.09 -0.03 0.697 regulator, fatty-acyl-binding STORAGE AND PROCESSING EcolC_2927 b0729 sucD succinyl-CoA synthetase, NAD(P)-binding, METABOLISM Energy 2.64 0.20 -0.24 -2.67 0.001 alpha subunit production and conversion EcolC_2928 b0728 sucC succinyl-CoA synthetase, beta subunit METABOLISM Energy 2.21 0.01 -0.14 -2.34 0.002 production and conversion EcolC_2929 b0727 sucB dihydrolipoyltranssuccinase METABOLISM Energy 2.20 -0.07 -0.21 -2.48 0.000 production and conversion EcolC_2930 b0726 sucA 2-oxoglutarate decarboxylase, thiamin- METABOLISM Energy 2.01 -0.83 0.20 -2.64 0.000 requiring production and conversion EcolC_2931 b0724 sdhB succinate dehydrogenase, FeS subunit METABOLISM Energy 1.33 -0.53 -0.12 -1.99 0.001 production and conversion EcolC_2932 b0723 sdhA succinate dehydrogenase, flavoprotein METABOLISM Energy 1.86 -0.43 0.13 -2.15 0.003 subunit production and conversion EcolC_2933 b0722 sdhD succinate dehydrogenase, membrane METABOLISM Energy 2.32 -1.16 0.19 -3.29 0.000 subunit, binds cytochrome b556 production and conversion EcolC_2934 b0721 sdhC succinate dehydrogenase, membrane METABOLISM Energy 1.58 -1.13 0.18 -2.53 0.000 subunit, binds cytochrome b556 production and conversion EcolC_2935 b0720 gltA citrate synthase METABOLISM Energy 1.65 0.01 -0.11 -1.75 0.012 production and conversion EcolC_2939 b0716 ybgO predicted fimbrial-like adhesin protein - - -0.14 0.01 -0.02 0.13 0.911 EcolC_2940 b0715 abrB regulator of aidB expression; inner POORLY General -0.18 -0.12 -0.12 -0.06 0.955 membrane protein CHARACTERIZ function ED prediction EcolC_2941 b0714 nei endonuclease VIII/ 5-formyluracil/5- INFORMATION Replication,l -0.01 0.11 -0.06 0.06 0.033 hydroxymethyluracil DNA glycosylase STORAGE AND recombination PROCESSING and repair EcolC_2942 b0713 ybgL conserved protein, UPF0271 family POORLY General -0.14 -0.10 -0.23 -0.19 0.747 CHARACTERIZ function ED prediction EcolC_2943 b0712 ybgK predicted allophanate hydrolase, subunit 2 METABOLISM Aminol acid -0.43 -0.68 -0.14 -0.40 0.107 transport and metabolism EcolC_2944 b0711 ybgJ predicted allophanate hydrolase, subunit 1 METABOLISM Amino acid -0.72 -0.85 -0.30 -0.43 0.535 transport and metabolism EcolC_2945 b0710 ybgI conserved metal-binding protein, NIF3 POORLY Function -0.60 -0.59 -0.24 -0.24 0.795 family CHARACTERIZ unknown ED EcolC_2946 b0709 dtpD dipeptide and tripeptide permease D METABOLISM Amino acid -0.12 -0.04 -0.03 0.05 0.415 transport and metabolism EcolC_2947 b0708 phr deoxyribodipyrimidine photolyase, FAD- INFORMATION Replication, -0.12 -0.18 -0.01 -0.08 0.090 binding STORAGE AND recombination PROCESSING and repair EcolC_2948 b0707 ybgA conserved protein, DUF1722 family POORLY Function -0.43 -0.64 0.20 -0.01 0.071 CHARACTERIZ unknown ED EcolC_2949 b0706 ybfD conserved protein INFORMATION Replication, 0.01 -0.08 -0.12 -0.21 0.979 STORAGE AND recombination PROCESSING and repair EcolC_2950 b1460 ydcC conserved protein INFORMATION Replication, 0.27 0.04 -0.02 -0.24 0.516 STORAGE AND recombination PROCESSING and repair EcolC_2952 b0704 ybfC predicted protein - - -0.09 -0.03 0.02 0.08 0.501 EcolC_2953 b0703 ybfO - - - -0.09 -0.21 0.01 -0.11 0.629 EcolC_2954 b0702 ybfB predicted membrane protein - - -0.26 -0.44 -0.29 -0.47 0.625 EcolC_2955 b0700 rhsC rhsC element core protein RshC CELLULAR Cell -0.27 -0.25 -0.14 -0.12 0.970 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2956 b0699 ybfA predicted protein - - 0.30 0.07 -0.02 -0.24 0.203 EcolC_2957 b4513 kdpF potassium ion accessory transporter subunit - - -0.15 -0.11 -0.10 -0.06 0.869

EcolC_2958 b0698 kdpA potassium translocating ATPase, subunit A METABOLISM Inorganic ion 0.20 0.55 0.01 0.36 0.014 transport and metabolism EcolC_2959 b0697 kdpB potassium translocating ATPase, subunit B METABOLISM Inorganic ion -0.07 0.05 -0.08 0.04 0.912 transport and metabolism EcolC_2960 b0696 kdpC potassium translocating ATPase, subunit C METABOLISM Inorganic ion -0.17 -0.11 -0.13 -0.08 0.781 transport and metabolism EcolC_2961 b0695 kdpD fused sensory histidine kinase in two- CELLULAR Signal 0.22 -0.13 0.03 -0.33 0.808 component regulatory system with KdpE: PROCESSES transduction signal sensing protein AND mechanisms SIGNALING EcolC_2962 b0694 kdpE DNA-binding response regulator in two- CELLULAR Signal -0.06 -0.16 0.00 -0.10 0.475 component regulatory system with KdpD PROCESSES transduction AND mechanisms SIGNALING EcolC_2963 b0693 speF ornithine decarboxylase isozyme, inducible METABOLISM Amino acid -0.08 0.13 0.10 0.31 0.214 transport and metabolism EcolC_2964 b0692 potE putrescine/proton symporter: METABOLISM Amino acid -0.24 -0.23 -0.12 -0.11 0.615 putrescine/ornithine antiporter transport and metabolism EcolC_2966 b0691 ybfG - - - -0.24 -0.24 -0.19 -0.19 0.641 EcolC_2967 b0689 ybfP lipoprotein - - -0.04 -0.07 0.00 -0.02 0.741 EcolC_2969 b0687 seqA regulatory protein for replication initiation INFORMATION Replication, 0.00 -0.07 -0.21 -0.28 0.892 STORAGE AND recombination PROCESSING and repair EcolC_2970 b0686 ybfF acyl-CoA esterase POORLY General 0.23 0.35 0.00 0.12 0.818 CHARACTERIZ function ED prediction EcolC_2972 b0684 fldA flavodoxin 1 METABOLISM Energyl 0.13 -0.06 -0.07 -0.26 0.233 production and conversion EcolC_2973 b0683 fur DNA-binding transcriptional dual regulator METABOLISM Inorganic ion 0.41 -0.03 0.05 -0.39 0.001 of siderophore biosynthesis and transport transport and metabolism EcolC_2974 b0682 chiQ novel lipoprotein induced by chitosugars - - 0.07 -0.05 0.11 -0.02 0.516 EcolC_2976 b0680 glnS glutamyl-tRNA synthetase INFORMATION Translation, 0.21 0.08 0.19 0.05 0.265 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2977 b0679 nagE fused N-acetyl glucosamine specific PTS METABOLISM Carbohydrate -0.74 -0.71 -0.11 -0.08 0.974 enzyme: IIC, IIB, and IIA components transport and metabolism EcolC_2978 b0678 nagB glucosamine-6-phosphate deaminase METABOLISM Carbohydrate -1.00 -0.77 -0.33 -0.10 0.114 transport and metabolism EcolC_2979 b0677 nagA N-acetylglucosamine-6-phosphate METABOLISM Carbohydrate -0.25 -0.50 -0.22 -0.47 0.046 deacetylase transport and metabolism EcolC_2981 b0675 nagD UMP phosphatase METABOLISM Carbohydrate -0.08 -0.05 -0.18 -0.15 0.556 transport and metabolism EcolC_2982 b0674 asnB asparagine synthetase B METABOLISM Amino acid -0.69 -0.61 -0.44 -0.36 0.263 transport and metabolism EcolC_2983 b0662 ubiF 2-octaprenyl-3-methyl-6-methoxy-1,4- METABOLISM Coenzyme 0.18 0.19 0.10 0.11 0.467 benzoquinol oxygenase transport and metabolism EcolC_2984 b0661 miaB tRNA-i(6)A37 methylthiotransferase INFORMATION Translation, -0.07 -0.28 0.07 -0.14 0.373 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_2985 b0660 ybeZ predicted protein with nucleoside CELLULAR Signal 0.42 0.17 0.00 -0.26 0.511 triphosphate hydrolase domain PROCESSES transduction AND mechanisms SIGNALING EcolC_2986 b0659 ybeY metal-binding heat shock protein required POORLY General 0.50 0.11 0.08 -0.31 0.005 for rRNA maturation CHARACTERIZ function ED prediction EcolC_2987 b0658 ybeX predicteed ion transport METABOLISM Inorganicl ion 0.39 -0.01 0.16 -0.24 0.021 transport and metabolism EcolC_2988 b0657 lnt apolipoprotein N-acyltransferase CELLULAR Cell 0.01 -0.05 -0.13 -0.19 0.885 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_2989 - - hypothetical protein POORLY Function 0.22 0.03 0.19 0.00 0.292 CHARACTERIZ unknown ED EcolC_2990 b0655 gltI glutamate, aspartate binding protein, METABOLISM Amino acid 4.57 1.22 0.29 -3.06 0.000 periplasmic; part of GltJKLI ABC transport and transporter metabolism EcolC_2991 b0654 gltJ glutamate, aspartate ABC transporter METABOLISM Amino acid 2.31 -0.07 0.16 -2.21 0.001 permease subunit transport and metabolism EcolC_2992 b0653 gltK glutamate, aspartate ABC transporter METABOLISM Amino acid 2.10 -0.37 -0.02 -2.49 0.001 permease subunit transport and metabolism EcolC_2993 b0652 gltL glutamate, aspartate ABC transporter ATP- METABOLISM Amino acid 1.24 -0.01 -0.05 -1.30 0.062 binding subunit transport and metabolism EcolC_2994 b0651 rihA ribonucleoside hydrolase 1 METABOLISM Nucleotide 0.18 1.85 -0.56 1.11 0.001 transport and metabolism EcolC_2995 b0650 hscC Hsp70 family chaperone Hsc62, binds to CELLULAR Posttranslatio 0.19 0.57 0.02 0.39 0.225 RpoD and inhibits transcription PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_2996 b0649 djlC Hsc56 co-chaperone of HscC - - -0.10 -0.12 0.05 0.03 0.858 EcolC_2997 b0648 ybeU conserved protein, DUF1266 family - - -0.16 -0.16 -0.12 -0.11 0.822 EcolC_2998 b0647 ybeT conserved protein, Sel1 family POORLY General -0.06 -0.08 -0.06 -0.08 0.742 CHARACTERIZ function ED prediction EcolC_2999 b0646 djlB predicted co-chaperone - -l -0.03 0.09 -0.04 0.08 0.113 EcolC_3000 b0645 ybeR predicted protein - - -0.27 -0.37 -0.19 -0.29 0.892 EcolC_3001 b0644 ybeQ conserved protein POORLY General -0.15 -0.21 -0.08 -0.14 0.813 CHARACTERIZ function ED prediction EcolC_3002 b0643 ybeL conserved protein, DUF1451 family - -l -0.01 0.64 -0.01 0.63 0.017 EcolC_3003 b0642 leuS leucyl-tRNA synthetase INFORMATION Translation, -0.35 -0.30 -0.29 -0.24 0.768 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3004 b0641 lptE LPS assembly OM complex LptDE, CELLULAR Cell -0.02 -0.12 -0.12 -0.21 0.995 lipoprotein component PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3005 b0640 holA DNA polymerase III, delta subunit INFORMATION Replication, -0.08 -0.21 -0.18 -0.31 0.682 STORAGE AND recombination PROCESSING and repair EcolC_3006 b0639 nadD nicotinic acid mononucleotide METABOLISM Coenzyme -0.18 -0.11 -0.23 -0.16 0.561 adenylyltransferase, NAD(P)-dependent transport and metabolism EcolC_3007 b0638 cobC predicted alpha-ribazole-5'-P phosphatase METABOLISM Carbohydrate 0.16 0.18 0.15 0.17 0.983 transport and metabolism EcolC_3008 b0637 rsfS ribosomal silencing factor POORLY Function 0.00 0.17 -0.15 0.02 0.337 CHARACTERIZ unknown ED EcolC_3009 b0636 rlmH 23S rRNA m(3)Psi1915 pseudouridine POORLY Function -0.03 -0.03 -0.09 -0.09 0.744 methyltransferase, SAM-dependent CHARACTERIZ unknown ED EcolC_3010 b0635 mrdA transpeptidase involved in peptidoglycan CELLULAR Cell 0.04 -0.02 -0.19 -0.24 0.238 synthesis (penicillin-binding protein 2) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3011 b0634 mrdB cell wall shape-determining protein CELLULAR Cell cycle -0.08 0.01 -0.08 0.02 0.748 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3012 b0633 rlpA septal ring protein, suppressor of prc, CELLULAR Cell -0.21 -0.07 -0.10 0.05 0.460 minor lipoprotein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3013 b0632 dacA D-alanyl-D-alanine carboxypeptidase CELLULAR Cell -0.14 0.16 -0.18 0.12 0.083 (penicillin-binding protein 5) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3014 b0631 ybeD conserved protein, UPF0250 family POORLY Function 0.10 0.04 -0.24 -0.29 0.774 CHARACTERIZ unknown ED EcolC_3015 b0630 lipB octanoyltransferase; octanoyl- METABOLISM Coenzyme -0.04 -0.02 -0.21 -0.19 0.863 [ACP]:protein N-octanoyltransferase transport and metabolism EcolC_3016 b0629 ybeF predicted DNA-binding transcriptional INFORMATION Transcription -0.30 -0.32 -0.32 -0.34 0.766 regulator STORAGE AND PROCESSING EcolC_3017 b0628 lipA lipoate synthase METABOLISM Coenzyme -0.24 -0.18 -0.22 -0.16 0.657 transport and metabolism EcolC_3018 b0627 tatE TatABCE protein translocation system - - -0.01 0.15 0.09 0.25 0.483 subunit EcolC_3020 b0624 crcB probable fluoride exporter; inner CELLULAR Cell cycle -0.13 0.07 0.09 0.29 0.557 membrane protein associated with PROCESSES control, cell chromosome condensation AND division, SIGNALING chromosome partitioning EcolC_3021 b0623 cspE DNA-binding transcriptional repressor INFORMATION Transcription 0.42 0.20 0.08 -0.14 0.143 STORAGE AND PROCESSING EcolC_3022 b0622 pagP phospholipid:lipid A palmitoyltransferase - - -0.14 -0.23 -0.16 -0.25 0.821 EcolC_3023 b0621 dcuC anaerobic C4-dicarboxylate transport METABOLISM Energy -1.13 -0.17 -0.46 0.50 0.018 production and conversion EcolC_3024 b0620 dpiA DNA-binding response regulator in two- INFORMATION Transcription -0.28 -0.02 -0.12 0.14 0.268 component regulatory system with citA STORAGE AND PROCESSING EcolC_3025 b0619 dpiB sensory histidine kinase in two-component CELLULAR Signal -0.90 -0.61 -0.80 -0.51 0.306 regulatory system with citB PROCESSES transduction AND mechanisms SIGNALING EcolC_3026 b0618 citC [citrate [pro-3S]-lyase] ligase METABOLISM Energy -0.21 -0.25 0.18 0.14 0.293 production and conversion EcolC_3027 b0617 citD citrate lyase, acyl carrier (gamma) subunit METABOLISM Energy -0.04 0.09 0.25 0.39 0.914 production and conversion EcolC_3028 b0616 citE citrate lyase, citryl-ACP lyase (beta) METABOLISM Carbohydrate 0.03 0.14 0.29 0.39 0.703 subunit transport and metabolism EcolC_3030 b0614 citX apo-citrate lyase phosphoribosyl- METABOLISM Coenzyme 0.00 0.20 0.03 0.24 0.180 dephospho-CoA transferase transport and metabolism EcolC_3031 b0613 citG 2-(5''-triphosphoribosyl)-3'- METABOLISM Coenzyme -0.10 -0.22 0.00 -0.12 0.249 dephosphocoenzyme-A synthase transport and metabolism EcolC_3032 b0612 citT citrate:succinate antiporter METABOLISM Inorganic ion -0.20 -0.21 -0.15 -0.16 0.742 transport and metabolism EcolC_3033 b0611 ribonuclease I INFORMATION Translation, 0.00 0.17 0.03 0.20 0.279 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3034 b0610 rnk regulator of nucleoside diphosphate kinase INFORMATION Transcription -0.15 0.11 0.00 0.26 0.051 STORAGE AND PROCESSING EcolC_3035 b0608 ybdR predicted oxidoreductase, Zn-dependent METABOLISM Amino acid -0.19 -0.09 -0.12 -0.01 0.325 and NAD(P)-binding transport and metabolism EcolC_3036 b0607 uspG universal stress protein UP12 CELLULAR Signal -0.20 -0.29 0.25 0.16 0.961 PROCESSES transduction AND mechanisms SIGNALING EcolC_3037 b0606 ahpF alkyl hydroperoxide reductase, F52a CELLULAR Posttranslatio -0.22 0.23 -0.30 0.14 0.007 subunit, FAD/NAD(P)-binding PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3038 b0605 ahpC alkyl hydroperoxide reductase, C22 subunit CELLULAR Posttranslatio 0.19 0.71 -0.44 0.08 0.016 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3039 b0604 dsbG thiol:disulfide interchange protein, CELLULAR Posttranslatio -0.17 0.13 0.09 0.39 0.181 periplasmic PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3040 b0603 ybdO predicted DNA-binding transcriptional INFORMATION Transcription -0.10 -0.18 -0.11 -0.18 0.860 regulator STORAGE AND PROCESSING EcolC_3041 b0602 ybdN conserved protein POORLY General -0.15 -0.18 -0.16 -0.20 0.382 CHARACTERIZ function ED prediction EcolC_3042 b0601 ybdM conserved protein INFORMATION Transcriptionl -0.08 -0.02 -0.03 0.02 0.938 STORAGE AND PROCESSING EcolC_3043 b0600 ybdL methionine aminotransferase, PLP- METABOLISM Amino acid -0.43 -0.26 -0.24 -0.07 0.233 dependent transport and metabolism EcolC_3044 b0599 ybdH predicted oxidoreductase METABOLISM Energy -0.02 0.16 -0.04 0.14 0.239 production and conversion EcolC_3045 b4512 ybdD conserved protein, DUF466 family POORLY Function -0.21 -0.12 -0.14 -0.05 0.479 CHARACTERIZ unknown ED EcolC_3046 b0598 cstA carbon starvation protein involved in CELLULAR Signal -1.14 -1.40 -0.68 -0.94 0.175 peptide utilization PROCESSES transduction AND mechanisms SIGNALING EcolC_3047 b0597 entH enterobactin synthesis proofreading METABOLISM Secondary 0.10 0.17 0.07 0.15 0.870 thioesterase metabolites biosynthesis, transport and catabolism EcolC_3048 b0596 entA 2,3-dihydro-2,3-dihydroxybenzoate METABOLISM Lipid 0.06 -0.01 0.08 0.01 0.943 dehydrogenase transport and metabolism EcolC_3049 b0595 entB isochorismatase METABOLISM Secondary 0.03 0.02 0.00 -0.02 0.838 metabolites biosynthesis, transport and catabolism EcolC_3050 b0594 entE 2,3-dihydroxybenzoate-AMP ligase METABOLISM Secondary -0.06 -0.20 -0.04 -0.18 0.398 component of enterobactin synthase metabolites multienzyme complex biosynthesis, transport and catabolism EcolC_3051 b0593 entC isochorismate synthase 1 METABOLISM Coenzyme -0.16 -0.16 -0.16 -0.15 0.617 transport and metabolism EcolC_3052 b0592 fepB iron-enterobactin transporter subunit METABOLISM Inorganic ion -0.23 -0.07 -0.06 0.09 0.332 transport and metabolism EcolC_3053 b0591 entS enterobactin exporter, iron-regulated - - -0.43 -0.36 -0.22 -0.14 0.586 EcolC_3054 b0590 fepD iron-enterobactin transporter subunit METABOLISM Inorganic ion -0.18 -0.15 -0.07 -0.05 0.878 transport and metabolism EcolC_3055 b0589 fepG iron-enterobactin transporter subunit METABOLISM Inorganic ion -0.35 -0.30 -0.22 -0.16 0.716 transport and metabolism EcolC_3056 b0588 fepC iron-enterobactin transporter subunit METABOLISM Inorganic ion -0.23 -0.22 -0.24 -0.22 0.997 transport and metabolism EcolC_3057 b0587 fepE regulator of length of O-antigen component CELLULAR Cell -0.21 -0.09 -0.07 0.05 0.206 of lipopolysaccharide chains PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3060 b0585 fes enterobactin/ferric enterobactin esterase METABOLISM Inorganic ion -0.09 -0.08 -0.13 -0.12 0.938 transport and metabolism EcolC_3062 b0583 entD phosphopantetheinyltransferase component METABOLISM Secondary -0.12 -0.12 0.01 0.01 0.899 of enterobactin synthase multienzyme metabolites complex biosynthesis, transport and catabolism EcolC_3064 b4415 hokE toxic polypeptide, small - - -0.23 -0.18 -0.15 -0.10 0.663 EcolC_3065 b0581 ybdK weak gamma-glutamyl:cysteine ligase POORLY Function -0.27 -0.69 0.16 -0.26 0.022 CHARACTERIZ unknown ED EcolC_3066 b0580 ybdJ predicted inner membrane protein - - -0.46 -0.67 -0.52 -0.73 0.876 EcolC_3067 b0579 ybdF conserved protein POORLY Function 0.04 -0.02 0.05 -0.01 0.856 CHARACTERIZ unknown ED EcolC_3068 b0578 nfsB dihydropteridine reductase, NAD(P)H- METABOLISM Energy -0.18 -0.32 -0.39 -0.53 0.182 dependent, oxygen-insensitive production and conversion EcolC_3069 b0577 ybdG mechanosensitive channel protein, CELLULAR Cell 0.28 0.24 0.05 0.01 0.671 miniconductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3070 b0576 pheP phenylalanine transporter METABOLISM Amino acid -0.16 -0.14 0.03 0.05 0.810 transport and metabolism EcolC_3071 b0575 cusA copper/silver efflux system, membrane METABOLISM Inorganic ion -0.13 -0.19 -0.08 -0.15 0.416 component transport and metabolism EcolC_3072 b0574 cusB copper/silver efflux system, membrane CELLULAR Cell -0.12 0.00 -0.02 0.11 0.575 fusion protein PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3073 b0573 cusF periplasmic copper- and silver-binding POORLY Function -0.17 -0.09 -0.07 0.01 0.826 protein CHARACTERIZ unknown ED EcolC_3074 b0572 cusC copper/silver efflux system, outer CELLULAR Cell -0.19 -0.36 -0.26 -0.42 0.041 membrane component PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3075 b0571 cusR DNA-binding response regulator in two- CELLULAR Signal 0.15 0.12 0.06 0.03 0.439 component regulatory system with CusS PROCESSES transduction AND mechanisms SIGNALING EcolC_3076 b0570 cusS sensory histidine kinase in two-component CELLULAR Signal -0.30 -0.15 -0.15 0.00 0.653 regulatory system with CusR, senses PROCESSES transduction copper ions AND mechanisms SIGNALING EcolC_3077 - - hypothetical protein POORLY Function 0.19 0.12 0.07 0.00 0.430 CHARACTERIZ unknown ED EcolC_3080 - - hypothetical protein - - -0.16 -0.09 -0.13 -0.07 0.473 EcolC_3081 - - hypothetical protein - - -0.19 0.09 0.03 0.31 0.038 EcolC_3083 b0569 nfrB bacteriophage N4 receptor, inner CELLULAR Cell -0.15 -0.11 -0.04 0.00 0.909 membrane subunit PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3084 b0568 nfrA bacteriophage N4 receptor, outer CELLULAR Intracellular 0.13 -0.05 0.04 -0.14 0.429 membrane subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_3085 b0567 ybcH predicted protein - - 0.10 0.19 0.16 0.26 0.603 EcolC_3086 b0566 envY DNA-binding transcriptional activator of INFORMATION Transcription 0.10 0.07 0.02 -0.01 0.947 porin biosynthesis STORAGE AND PROCESSING EcolC_3087 b0535 fimZ predicted DNA-binding transcriptional CELLULAR Signal -0.26 -0.33 -0.21 -0.27 0.440 regulator PROCESSES transduction AND mechanisms SIGNALING EcolC_3088 b0534 sfmF predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.06 -0.05 0.07 0.08 0.862 PROCESSES AND SIGNALING EcolC_3089 b0533 sfmH predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.30 -0.16 -0.17 -0.03 0.408 PROCESSES AND SIGNALING EcolC_3090 b0532 sfmD predicted outer membrane export usher CELLULAR Cell motility -0.42 -0.39 -0.20 -0.18 0.842 protein PROCESSES AND SIGNALING EcolC_3091 b0531 sfmC pilin chaperone, periplasmic CELLULAR Cell motility -0.31 -0.56 -0.45 -0.70 0.332 PROCESSES AND SIGNALING EcolC_3092 b0530 sfmA predicted fimbrial-like adhesin protein CELLULAR Cell motility -0.26 -0.24 -0.18 -0.16 0.732 PROCESSES AND SIGNALING EcolC_3093 b0529 folD bifunctional 5,10-methylene- METABOLISM Coenzyme -0.17 -0.11 -0.06 0.00 0.711 tetrahydrofolate dehydrogenase/ 5,10- transport and methylene-tetrahydrofolate cyclohydrolase metabolism EcolC_3094 b0528 ybcJ ribosome-associated protein; predicted POORLY Function -0.25 0.08 -0.06 0.27 0.034 RNA-binding protein CHARACTERIZ unknown ED EcolC_3095 b0527 ybcI inner membrane protein, DUF457 family POORLY General 0.28 0.46 0.25 0.42 0.048 CHARACTERIZ function ED prediction EcolC_3096 b0526 cysS cysteinyl-tRNA synthetase INFORMATION Translation,l -0.41 0.02 -0.18 0.25 0.021 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3097 b0525 ppiB peptidyl-prolyl cis-trans isomerase B CELLULAR Posttranslatio -0.31 0.00 -0.19 0.12 0.130 (rotamase B) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3098 b0524 lpxH UDP-2,3-diacylglucosamine POORLY Function 0.00 -0.06 -0.04 -0.11 0.883 pyrophosphatase CHARACTERIZ unknown ED EcolC_3099 b0523 purE N5-carboxyaminoimidazole ribonucleotide METABOLISM Nucleotide -0.26 -0.05 -0.07 0.14 0.911 mutase transport and metabolism EcolC_3100 b0522 purK N5-carboxyaminoimidazole ribonucleotide METABOLISM Nucleotide -0.18 0.00 -0.15 0.03 0.251 synthase transport and metabolism EcolC_3102 b0520 ylbF conserved protein - - -0.29 -0.31 -0.32 -0.34 0.851 EcolC_3103 b4572 ylbE - - - -0.15 -0.17 -0.10 -0.12 0.797 EcolC_3104 b0518 fdrA multicopy suppressor of dominant negative METABOLISM Energy -0.16 -0.16 -0.22 -0.21 0.863 ftsH mutations; predicted acyl-CoA production synthetase with NAD(P)-binding and Rossmann-fold domain conversion EcolC_3105 b0517 allD ureidoglycolate dehydrogenase METABOLISM Energy 0.06 0.13 -0.15 -0.07 0.447 production and conversion EcolC_3107 b1994 insH1 IS5 transposase and trans-activator INFORMATION Replication, 1.27 1.44 0.36 0.53 0.584 STORAGE AND recombination PROCESSING and repair EcolC_3108 b0515 ylbA conserved protein POORLY General 0.07 -0.05 -0.16 -0.28 0.776 CHARACTERIZ function ED prediction l EcolC_3109 b0514 glxK glycerate kinase II METABOLISM Carbohydrate 1.10 0.07 -0.18 -1.21 0.060 transport and metabolism EcolC_3110 b0513 ybbY predicted uracil/xanthine transporter METABOLISM Nucleotide -0.32 -0.12 -0.58 -0.38 0.997 transport and metabolism EcolC_3111 b0512 allB allantoinase METABOLISM Nucleotide 6.16 4.70 -0.09 -1.54 0.002 transport and metabolism EcolC_3112 b0511 ybbW predicted allantoin transporter METABOLISM Nucleotide 0.93 0.06 -0.03 -0.90 0.030 transport and metabolism EcolC_3113 b0509 glxR tartronate semialdehyde reductase, NADH- METABOLISM Lipid 4.15 1.60 -0.16 -2.71 0.013 dependent transport and metabolism EcolC_3114 b0508 hyi hydroxypyruvate isomerase METABOLISM Carbohydrate 3.29 0.59 -0.02 -2.72 0.005 transport and metabolism EcolC_3115 b0507 gcl glyoxylate carboligase POORLY General 2.74 0.77 -0.04 -2.01 0.045 CHARACTERIZ function ED prediction EcolC_3116 b0506 allR DNA-binding transcriptional repressor for INFORMATION Transcriptionl 0.10 -0.11 -0.10 -0.30 0.395 all (allantoin) and gcl (glyoxylate) operons; STORAGE AND glyoxylate-induced PROCESSING EcolC_3117 b0505 allA ureidoglycolate hydrolase METABOLISM Nucleotide 1.24 0.50 0.05 -0.69 0.044 transport and metabolism EcolC_3118 b0504 allS DNA-binding transcriptional activator of INFORMATION Transcription 0.24 0.31 0.00 0.07 0.753 the allD operon STORAGE AND PROCESSING EcolC_3119 b0503 mnmH tRNA 2-selenouridine synthase, POORLY General 0.12 -0.02 0.08 -0.05 0.936 selenophosphate-dependent CHARACTERIZ function ED prediction EcolC_3120 b0496 ybbP predicted ABC transporter permease METABOLISM Secondaryl 0.41 0.15 0.09 -0.17 0.680 metabolites biosynthesis, transport and catabolism EcolC_3121 b0495 ybbA predicted transporter subunit: ATP-binding METABOLISM Secondary -0.08 -0.30 -0.27 -0.49 0.516 component of ABC superfamily metabolites biosynthesis, transport and catabolism EcolC_3122 b0494 tesA multifunctional acyl-CoA thioesterase I and METABOLISM Amino acid 0.81 -0.12 0.09 -0.84 0.008 protease I and L1 transport and metabolism EcolC_3123 b0493 ybbO predicted oxidoreductase with NAD(P)- POORLY General 0.00 -0.07 -0.09 -0.17 0.604 binding Rossmann-fold domain CHARACTERIZ function ED prediction EcolC_3124 b0492 ybbN DnaK co-chaperone, thioredoxin-like CELLULAR Posttranslatiol -0.04 0.39 -0.17 0.26 0.178 protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3125 b0491 ybbM inner membrane protein, UPF0014 family POORLY General -0.19 -0.43 -0.42 -0.66 0.461 CHARACTERIZ function ED prediction EcolC_3126 b0490 ybbL predicted transporter subunit: ATP-binding POORLY Generall 0.11 0.05 0.01 -0.04 0.921 component of ABC superfamily CHARACTERIZ function ED prediction l EcolC_3127 b0489 qmcA multicopy suppressor of ftsH htpX double CELLULAR Posttranslatio -0.03 -0.37 -0.10 -0.45 0.036 mutant; membrane-anchored predicted PROCESSES nal protease with C-terminal cytoplasmic PHB AND modification, domain SIGNALING protein turnover, chaperones EcolC_3128 b0488 ybbJ inner membrane protein that stimulates the CELLULAR Posttranslatio -0.12 0.02 0.06 0.21 0.903 ftsH htpX mutant suppressor activity of PROCESSES nal QmcA AND modification, SIGNALING protein turnover, chaperones EcolC_3129 b0487 cueR DNA-binding transcriptional activator of INFORMATION Transcription 0.14 0.02 -0.01 -0.13 0.446 copper-responsive regulon genes STORAGE AND PROCESSING EcolC_3130 b0486 ybaT predicted amino acid transporter METABOLISM Amino acid 0.00 -0.14 0.08 -0.06 0.373 transport and metabolism EcolC_3131 b0485 glsA glutaminase 1 METABOLISM Amino acid -0.04 -0.65 0.22 -0.40 0.132 transport and metabolism EcolC_3133 b0483 ybaQ predicted DNA-binding transcriptional POORLY General 0.09 0.24 0.49 0.65 0.594 regulator CHARACTERIZ function ED prediction EcolC_3134 b0482 ybaP conserved protein, TraB family POORLY Functionl -0.33 -0.40 0.00 -0.07 0.762 CHARACTERIZ unknown ED EcolC_3135 b0481 ybaK conserved protein POORLY Function -0.14 0.03 -0.05 0.12 0.174 CHARACTERIZ unknown ED EcolC_3136 b0480 ushA bifunctional UDP-sugar hydrolase/5'- METABOLISM Nucleotide -0.38 -0.06 -0.33 -0.01 0.029 nucleotidase transport and metabolism EcolC_3137 b0479 fsr predicted fosmidomycin efflux system METABOLISM Inorganic ion -0.67 -0.63 -0.47 -0.43 0.593 transport and metabolism EcolC_3138 b0478 ybaL predicted transporter with NAD(P)-binding METABOLISM Inorganic ion 1.36 0.16 -0.30 -1.49 0.012 Rossmann-fold domain transport and metabolism EcolC_3139 b0477 gsk inosine/guanosine kinase METABOLISM Carbohydrate -0.04 0.14 -0.17 0.01 0.217 transport and metabolism EcolC_3140 b0476 aes acetyl esterase METABOLISM Lipid 0.03 0.18 -0.18 -0.04 0.606 transport and metabolism EcolC_3141 b0475 hemH ferrochelatase METABOLISM Coenzyme -0.24 -0.70 0.11 -0.36 0.022 transport and metabolism EcolC_3142 b0474 adk METABOLISM Nucleotide -0.38 -0.13 -0.46 -0.21 0.574 transport and metabolism EcolC_3143 b0473 htpG protein refolding molecular co-chaperone CELLULAR Posttranslatio 1.23 0.71 0.08 -0.44 0.030 Hsp90, Hsp70-dependent; heat-shock PROCESSES nal protein; ATPase AND modification, SIGNALING protein turnover, chaperones EcolC_3144 b0472 recR gap repair protein INFORMATION Replication, -0.12 0.14 -0.09 0.17 0.025 STORAGE AND recombination PROCESSING and repair EcolC_3145 b0471 ybaB conserved protein POORLY Function -0.28 -0.17 -0.22 -0.11 0.175 CHARACTERIZ unknown ED EcolC_3146 b0470 dnaX DNA polymerase III/DNA elongation INFORMATION Replication, -0.23 -0.10 -0.24 -0.12 0.127 factor III, tau and gamma subunits STORAGE AND recombination PROCESSING and repair EcolC_3147 b0469 apt adenine phosphoribosyltransferase METABOLISM Nucleotide -1.21 -0.68 -0.40 0.13 0.098 transport and metabolism EcolC_3148 b0468 ybaN inner membrane protein, DUF454 family POORLY Function -0.15 -0.15 -0.11 -0.11 0.935 CHARACTERIZ unknown ED EcolC_3149 b0467 priC primosomal replication protein N' INFORMATION Replication, -0.10 -0.15 -0.26 -0.31 0.561 STORAGE AND recombination PROCESSING and repair EcolC_3150 b0466 ybaM predicted protein - - 0.14 0.01 -0.22 -0.35 0.943 EcolC_3151 b0465 mscK mechanosensitive channel protein, CELLULAR Cell -0.04 -0.12 -0.21 -0.29 0.382 intermediate conductance, K+ regulated PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3152 b0464 acrR DNA-binding transcriptional repressor INFORMATION Transcription 0.29 0.33 -0.04 0.00 0.989 STORAGE AND PROCESSING EcolC_3153 b0463 acrA multidrug efflux system CELLULAR Cell 2.49 -0.23 -0.56 -3.27 0.001 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3154 b0462 acrB multidrug efflux system protein CELLULAR Defense 1.28 -0.24 -0.54 -2.06 0.011 PROCESSES mechanisms AND SIGNALING EcolC_3155 b0461 tomB Hha toxicity attenuator; conjugation- - - -0.03 -0.65 0.07 -0.55 0.111 related protein EcolC_3156 b0460 hha modulator of gene expression, with H-NS - - -0.02 -0.66 0.28 -0.37 0.002 EcolC_3157 b0459 maa maltose O-acetyltransferase POORLY General 0.03 0.02 0.02 0.01 0.738 CHARACTERIZ function ED prediction EcolC_3158 b0458 ylaC inner membrane protein, DUF1449 family - -l -0.39 -0.69 -0.53 -0.84 0.030 EcolC_3159 b0457 ylaB predicted membrane-anchored cyclic-di- CELLULAR Signal -0.04 -0.23 -0.04 -0.23 0.721 GMP phosphodiesterase PROCESSES transduction AND mechanisms SIGNALING EcolC_3160 b0456 ybaA conserved protein, DUF1428 family POORLY Function 0.11 -0.06 0.05 -0.13 0.273 CHARACTERIZ unknown ED EcolC_3161 b0454 ybaZ excision repair protein, alkyltransferase- INFORMATION Replication, 0.26 0.31 0.14 0.19 0.579 like protein ATL STORAGE AND recombination PROCESSING and repair EcolC_3162 b0453 ybaY outer membrane lipoprotein POORLY Function -0.31 -0.33 0.11 0.09 0.789 CHARACTERIZ unknown ED EcolC_3163 b0452 tesB acyl-CoA thioesterase II METABOLISM Lipid 0.07 -0.08 -0.09 -0.24 0.763 transport and metabolism EcolC_3164 b0451 amtB ammonium transporter METABOLISM Inorganic ion -0.19 -0.02 -0.16 0.01 0.238 transport and metabolism EcolC_3165 b0450 glnK nitrogen assimilation regulatory protein for METABOLISM Amino acid -0.18 -0.11 -0.17 -0.10 0.623 GlnL, GlnE, and AmtB transport and metabolism EcolC_3166 b0449 mdlB fused predicted multidrug transporter CELLULAR Defense 0.18 -0.07 -0.17 -0.41 0.335 subunits of ABC superfamily: ATP-binding PROCESSES mechanisms components AND SIGNALING EcolC_3167 b0448 mdlA fused predicted multidrug transporter CELLULAR Defense 0.15 -0.13 -0.22 -0.50 0.162 subunits of ABC superfamily: ATP-binding PROCESSES mechanisms components AND SIGNALING EcolC_3168 b0447 ybaO predicted DNA-binding transcriptional INFORMATION Transcription 0.34 -0.05 -0.25 -0.64 0.216 regulator STORAGE AND PROCESSING EcolC_3169 b0446 cof thiamin pyrimidine pyrophosphate POORLY General -0.26 -0.20 -0.24 -0.18 0.623 hydrolase; HMP-PP phosphatase CHARACTERIZ function ED prediction EcolC_3170 b0264 insB1 IS1 transposase B INFORMATION Replication,l 0.31 1.03 0.19 0.91 0.005 STORAGE AND recombination PROCESSING and repair EcolC_3170 b0021 insB1 IS1 transposase B INFORMATION Replication, 0.17 0.51 0.41 0.75 0.010 STORAGE AND recombination PROCESSING and repair EcolC_3185 b4294 insA IS1 repressor TnpA INFORMATION Replication, -0.15 0.47 0.30 0.92 0.014 STORAGE AND recombination PROCESSING and repair EcolC_3187 b0445 ybaE predicted transporter subunit: periplasmic- POORLY General 0.12 -0.34 0.00 -0.45 0.020 binding component of ABC superfamily CHARACTERIZ function ED prediction EcolC_3188 b0444 queC 7-cyano-7-deazaguanine (preQ0) synthase; POORLY Generall -0.27 -0.01 -0.14 0.12 0.012 queuosine biosynthesis CHARACTERIZ function ED prediction EcolC_3189 b0443 fadM long-chain acyl-CoA thioesterase III POORLY Generall -0.14 -0.15 -0.22 -0.24 0.631 CHARACTERIZ function ED prediction l EcolC_3190 b0442 ybaV conserved protein, ComEA homolog INFORMATION Replication, -0.12 -0.01 0.10 0.21 0.413 STORAGE AND recombination PROCESSING and repair EcolC_3191 b0441 ppiD periplasmic folding chaperone, has an CELLULAR Posttranslatio -0.12 -0.13 -0.48 -0.50 0.943 inactive PPIase domain PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3192 b0440 hupB HU, DNA-binding transcriptional INFORMATION Replication, -1.37 -1.28 -0.34 -0.25 0.430 regulator, beta subunit STORAGE AND recombination PROCESSING and repair EcolC_3193 b0439 lon DNA-binding ATP-dependent protease La CELLULAR Posttranslatio -0.24 -0.32 -0.45 -0.53 0.413 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3194 b0438 clpX ATPase and specificity subunit of ClpX- CELLULAR Posttranslatio -0.06 -0.34 -0.11 -0.39 0.018 ClpP ATP-dependent serine protease PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3195 b0437 clpP proteolytic subunit of ClpA-ClpP and CELLULAR Posttranslatio -0.25 -0.62 -0.29 -0.65 0.261 ClpX-ClpP ATP-dependent serine PROCESSES nal proteases AND modification, SIGNALING protein turnover, chaperones EcolC_3196 b0436 tig peptidyl-prolyl cis/trans isomerase (trigger CELLULAR Posttranslatio -1.42 -1.06 -0.48 -0.11 0.358 factor) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3198 b0435 bolA stationary-phase morphogene, CELLULAR Signal -1.22 -1.27 0.47 0.42 0.960 transcriptional repressor for mreB; also PROCESSES transduction regulator for dacA, dacC, and ampC AND mechanisms SIGNALING EcolC_3199 b0434 yajG predicted lipoprotein CELLULAR Cell -0.16 -0.25 -0.17 -0.25 0.370 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3200 b0433 ampG muropeptide transporter METABOLISM Carbohydrate -0.29 -0.47 -0.33 -0.51 0.734 transport and metabolism EcolC_3201 b0432 cyoA cytochrome o ubiquinol oxidase subunit II METABOLISM Energy 3.21 -0.73 0.17 -3.77 0.000 production and conversion EcolC_3202 b0431 cyoB cytochrome o ubiquinol oxidase subunit I METABOLISM Energy 1.90 -0.99 0.11 -2.78 0.001 production and conversion EcolC_3203 b0430 cyoC cytochrome o ubiquinol oxidase subunit III METABOLISM Energy 2.09 -0.91 0.06 -2.94 0.001 production and conversion EcolC_3204 b0429 cyoD cytochrome o ubiquinol oxidase subunit IV METABOLISM Energy 1.46 -0.49 0.12 -1.83 0.004 production and conversion EcolC_3205 b0428 cyoE protoheme IX farnesyltransferase CELLULAR Posttranslatio 1.26 -0.29 0.19 -1.36 0.014 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3206 b0427 yajR predicted transporter METABOLISM Carbohydrate 0.15 0.14 0.33 0.32 0.814 transport and metabolism EcolC_3207 b0426 yajQ phage Phi6 host factor, ATP/GTP binding POORLY Function 0.05 -0.16 -0.14 -0.35 0.747 protein CHARACTERIZ unknown ED EcolC_3208 b0425 panE 2-dehydropantoate reductase, NADPH- METABOLISM Coenzyme -0.01 -0.23 -0.16 -0.39 0.285 specific transport and metabolism EcolC_3209 b0424 yajL oxidative-stress-resistance chaperone POORLY General -0.29 -0.25 -0.28 -0.25 0.920 CHARACTERIZ function ED prediction EcolC_3210 b0423 thiI tRNA s(4)U8 sulfurtransferase METABOLISM Coenzymel -0.52 -0.68 -0.56 -0.71 0.562 transport and metabolism EcolC_3211 b0422 xseB exonuclease VII small subunit INFORMATION Replication, 0.57 0.58 -0.48 -0.47 0.639 STORAGE AND recombination PROCESSING and repair EcolC_3212 b0421 ispA geranyltranstransferase METABOLISM Coenzyme 0.63 0.33 -0.34 -0.64 0.389 transport and metabolism EcolC_3213 b0420 dxs 1-deoxyxylulose-5-phosphate synthase, METABOLISM Coenzyme 0.67 0.30 -0.33 -0.70 0.393 thiamine-requiring, FAD-requiring transport and metabolism EcolC_3214 b0419 yajO 2-carboxybenzaldehyde reductase METABOLISM Energy -0.51 -0.05 -0.25 0.21 0.018 production and conversion EcolC_3215 b0418 pgpA phosphatidylglycerophosphatase A METABOLISM Lipid 0.05 0.43 -0.12 0.26 0.008 transport and metabolism EcolC_3217 b0416 nusB transcription antitermination protein INFORMATION Transcription 0.02 0.14 -0.14 -0.02 0.386 STORAGE AND PROCESSING EcolC_3218 b0415 ribE riboflavin synthase beta chain METABOLISM Coenzyme 0.33 0.36 -0.24 -0.21 0.317 transport and metabolism EcolC_3219 b0414 ribD fused METABOLISM Coenzyme 0.18 0.12 -0.29 -0.35 0.902 diaminohydroxyphosphoribosylaminopyri transport and midine deaminase and 5-amino-6-(5- metabolism phosphoribosylamino) uracil reductase EcolC_3220 b0413 nrdR conserved protein INFORMATION Transcription 0.40 -0.08 -0.23 -0.71 0.154 STORAGE AND PROCESSING EcolC_3221 b0412 yajI predicted lipoprotein - - -0.30 -0.17 -0.07 0.06 0.975 EcolC_3222 b0411 tsx nucleoside channel, receptor of phage T6 CELLULAR Cell 0.00 -0.41 -0.38 -0.79 0.015 and colicin K PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3223 b0410 yajD HNH nuclease family protein - - -0.56 -0.48 -0.13 -0.05 0.420 EcolC_3224 b0409 secF SecYEG protein translocase auxillary CELLULAR Intracellular -0.12 -0.39 -0.36 -0.63 0.113 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_3225 b0408 secD SecYEG protein translocase auxillary CELLULAR Intracellular 0.24 -0.22 -0.33 -0.80 0.143 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_3226 b0407 yajC SecYEG protein translocase auxillary CELLULAR Intracellular 0.17 -0.21 -0.51 -0.89 0.093 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_3227 b0406 tgt tRNA-guanine transglycosylase INFORMATION Translation, -0.17 -0.28 -0.25 -0.36 0.082 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3228 b0405 queA S-adenosylmethionine:tRNA INFORMATION Translation, -0.45 -0.35 -0.43 -0.33 0.599 ribosyltransferase-isomerase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3229 b0404 acpH conserved protein POORLY Function -0.16 -0.28 -0.30 -0.42 0.225 CHARACTERIZ unknown ED EcolC_3230 b0403 malZ maltodextrin glucosidase METABOLISM Carbohydrate -0.17 -0.06 -0.10 0.01 0.460 transport and metabolism EcolC_3231 b0402 proY proline-specific permease METABOLISM Amino acid -0.20 -0.25 -0.17 -0.22 0.887 transport and metabolism EcolC_3232 b0401 brnQ branched-chain amino acid transport METABOLISM Amino acid -0.30 -0.38 -0.19 -0.26 0.853 system 2 carrier protein; LIV-II transport transport and system for Ile, Leu, and Val metabolism EcolC_3233 b0400 phoR sensory histidine kinase in two-component CELLULAR Signal 0.05 -0.03 -0.27 -0.35 0.579 regulatory system with PhoB PROCESSES transduction AND mechanisms SIGNALING EcolC_3234 b0399 phoB DNA-binding response regulator in two- CELLULAR Signal 0.05 0.22 -0.15 0.02 0.406 component regulatory system with PhoR PROCESSES transduction (or CreC) AND mechanisms SIGNALING EcolC_3235 b0398 sbcD exonuclease, dsDNA, ATP-dependent INFORMATION Replication, -0.39 -0.36 -0.11 -0.08 0.999 STORAGE AND recombination PROCESSING and repair EcolC_3237 b0396 araJ arabinose-inducible predicted transporter, METABOLISM Carbohydrate 0.06 0.02 -0.04 -0.07 0.748 MFS family transport and metabolism EcolC_3238 b0394 mak manno(fructo)kinase INFORMATION Transcription -0.32 -0.09 -0.08 0.15 0.322 STORAGE AND PROCESSING EcolC_3239 b0393 rdgC nucleoid-associated ssDNA and dsDNA INFORMATION Replication, -0.33 -0.16 -0.25 -0.08 0.715 binding protein; competitive inhibitor of STORAGE AND recombination RecA function PROCESSING and repair EcolC_3240 b0392 ykiA - - - -0.29 -0.43 -0.28 -0.42 0.464 EcolC_3241 b0391 yaiE conserved protein, UPF0345 family POORLY Function -0.49 -0.56 -0.38 -0.44 0.767 CHARACTERIZ unknown ED EcolC_3242 b0390 aroM conserved protein, AroM family - - -0.08 -0.16 -0.22 -0.31 0.809 EcolC_3243 b0389 yaiA OxyR-regulated conserved protein - - -0.39 -0.52 0.13 -0.01 0.538 EcolC_3244 b0388 aroL shikimate kinase II METABOLISM Amino acid -0.40 -0.22 -0.17 0.00 0.175 transport and metabolism EcolC_3245 b0387 yaiI conserved protein, UPF0178 family, POORLY Function 0.16 0.44 -0.28 0.00 0.018 downregulated by beryllium CHARACTERIZ unknown ED EcolC_3246 b0386 proC pyrroline-5-carboxylate reductase, METABOLISM Amino acid -0.74 -0.38 -0.50 -0.14 0.365 NAD(P)-binding transport and metabolism EcolC_3247 b0385 yaiC diguanylate cyclase, cellulose regualtor CELLULAR Signal -0.26 -0.23 -0.20 -0.17 0.902 PROCESSES transduction AND mechanisms SIGNALING EcolC_3248 b0384 psiF conserved protein, PsiF family, pho - - -0.59 -1.00 0.23 -0.19 0.373 EcolC_3249 b0383 phoA bacterial alkaline phosphatase METABOLISM Inorganic ion -0.28 -0.15 -0.21 -0.07 0.865 transport and metabolism EcolC_3250 b0382 iraP anti-RssB factor, RpoS stabilzer during Pi - - -0.06 -0.28 -0.18 -0.40 0.529 starvation; anti-adapter protein EcolC_3251 b0381 ddlA D-alanine-D-alanine ligase A CELLULAR Cell -0.05 -0.02 -0.03 0.00 0.843 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3252 b0380 yaiZ predicted inner membrane protein, - - 0.26 -0.02 -0.07 -0.35 0.026 DUF2754 family EcolC_3253 b0379 yaiY inner membrane protein, DUF2755 family - - 0.41 -0.04 -0.04 -0.49 0.235 EcolC_3254 b0378 yaiW probable lipoprotein required for swarming - - 0.15 0.04 -0.14 -0.25 0.911 phenotype EcolC_3255 b0377 sbmA microcin B17 transporter METABOLISM Lipid -0.86 -1.05 -1.20 -1.39 0.421 transport and metabolism EcolC_3256 b0376 ampH D-alanyl-D-alanine- CELLULAR Defense 0.35 -0.07 0.05 -0.37 0.076 carboxypeptidase/endopeptidase; PROCESSES mechanisms penicillin-binding protein; weak beta- AND lactamase SIGNALING EcolC_3259 b0369 hemB 5-aminolevulinate dehydratase METABOLISM Coenzyme 0.35 -0.06 -0.30 -0.71 0.016 (porphobilinogen synthase) transport and metabolism EcolC_3260 b0368 tauD taurine dioxygenase, 2-oxoglutarate- METABOLISM Secondary -0.23 -0.38 -0.17 -0.32 0.937 dependent metabolites biosynthesis, transport and catabolism EcolC_3261 b0367 tauC taurine transporter subunit METABOLISM Inorganic ion -0.10 -0.06 -0.17 -0.14 0.827 transport and metabolism EcolC_3262 b0366 tauB taurine transporter subunit METABOLISM Inorganic ion -0.05 -0.02 -0.07 -0.04 0.617 transport and metabolism EcolC_3263 b0365 tauA taurine transporter subunit METABOLISM Inorganic ion 0.03 -0.18 -0.11 -0.33 0.126 transport and metabolism EcolC_3264 b0364 yaiS conserved protein POORLY Function -0.16 -0.07 -0.15 -0.06 0.976 CHARACTERIZ unknown ED EcolC_3265 b0363 yaiP predicted glucosyltransferase CELLULAR Cell -0.02 -0.09 -0.07 -0.13 0.804 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3267 b0358 yaiO outer membrane protein - - -0.05 -0.06 -0.11 -0.12 0.839 EcolC_3268 b0357 frmR regulator protein that represses frmRAB POORLY Function -0.18 -0.23 -0.41 -0.46 0.683 operon CHARACTERIZ unknown ED EcolC_3269 b0356 frmA alcohol dehydrogenase class METABOLISM Energy -0.15 -0.03 -0.24 -0.12 0.536 III/glutathione-dependent formaldehyde production dehydrogenase and conversion EcolC_3270 b0355 frmB S-formylglutathione hydrolase POORLY General -0.21 -0.29 -0.08 -0.15 0.659 CHARACTERIZ function ED prediction EcolC_3271 b0354 yaiL DUF2058 family protein POORLY Functionl 0.16 0.11 0.28 0.22 0.478 CHARACTERIZ unknown ED EcolC_3272 b0353 mhpT predicted 3-hydroxyphenylpropionic METABOLISM Carbohydrate -0.03 -0.03 -0.23 -0.22 0.835 transporter transport and metabolism EcolC_3273 b0352 mhpE 4-hyroxy-2-oxovalerate/4-hydroxy-2- METABOLISM Amino acid 0.12 -0.03 -0.04 -0.18 0.578 oxopentanoic acid aldolase, class I transport and metabolism EcolC_3274 b0351 mhpF acetaldehyde-CoA dehydrogenase II, NAD- METABOLISM Secondary -0.26 -0.16 -0.24 -0.14 0.442 binding metabolites biosynthesis, transport and catabolism EcolC_3275 b0350 mhpD 2-keto-4-pentenoate hydratase METABOLISM Secondary -0.17 -0.24 -0.49 -0.56 0.889 metabolites biosynthesis, transport and catabolism EcolC_3277 b0348 mhpB 2,3-dihydroxyphenylpropionate 1,2- - - -0.08 -0.01 -0.14 -0.07 0.541 dioxygenase EcolC_3278 b0347 mhpA 3-(3-hydroxyphenyl)propionate METABOLISM Coenzyme -0.01 0.27 0.05 0.33 0.123 hydroxylase transport and metabolism EcolC_3280 b0345 lacI DNA-binding transcriptional repressor INFORMATION Transcription -0.29 -0.29 -0.20 -0.20 0.930 STORAGE AND PROCESSING EcolC_3281 b0344 lacZ beta-D-galactosidase METABOLISM Carbohydrate -0.26 -0.33 -0.04 -0.11 0.974 transport and metabolism EcolC_3282 b0343 lacY lactose permease METABOLISM Inorganic ion -1.25 -0.68 -0.43 0.15 0.079 transport and metabolism EcolC_3283 b0342 lacA thiogalactoside acetyltransferase POORLY General -0.41 -0.20 -0.24 -0.02 0.303 CHARACTERIZ function ED prediction EcolC_3284 b0341 cynX predicted cyanate transporter METABOLISM Inorganicl ion -0.25 -0.35 -0.18 -0.28 0.382 transport and metabolism EcolC_3285 b0340 cynS cyanate aminohydrolase METABOLISM Inorganic ion -0.30 -0.39 -0.29 -0.38 0.748 transport and metabolism EcolC_3286 b0339 cynT carbonic anhydrase METABOLISM Inorganic ion -0.04 0.06 -0.03 0.06 0.966 transport and metabolism EcolC_3287 b0338 cynR transcriptional activator of cyn operon; INFORMATION Transcription -0.51 -0.25 -0.36 -0.09 0.239 autorepressor STORAGE AND PROCESSING EcolC_3288 b0337 codA cytosine/isoguanine deaminase METABOLISM Nucleotide -0.38 -0.06 -0.12 0.20 0.126 transport and metabolism EcolC_3289 b0336 codB cytosine transporter METABOLISM Nucleotide -1.38 -1.08 -1.40 -1.10 0.398 transport and metabolism EcolC_3290 b0335 prpE propionate--CoA ligase METABOLISM Lipid 0.02 -0.28 -0.11 -0.41 0.177 transport and metabolism EcolC_3291 b0334 prpD 2-methylcitrate dehydratase POORLY General -0.06 0.19 -0.25 0.00 0.475 CHARACTERIZ function ED prediction EcolC_3292 b0333 prpC 2-methylcitrate synthase METABOLISM Energyl -0.24 -0.22 -1.49 -1.47 0.389 production and conversion EcolC_3293 b0331 prpB 2-methylisocitrate lyase METABOLISM Carbohydrate -0.05 -0.01 -0.26 -0.22 0.637 transport and metabolism EcolC_3294 b0330 prpR propionate catabolism operon regulatory INFORMATION Transcription -0.11 -0.27 0.01 -0.15 0.149 protein STORAGE AND PROCESSING EcolC_3295 b0329 yahO periplasmic protein, function unknown, - - -0.09 -0.22 0.24 0.12 0.404 YhcN family EcolC_3296 b0328 yahN amino acid exporter for proline, lysine, METABOLISM Amino acid 0.14 0.26 -0.33 -0.21 0.345 glutamate, homoserine transport and metabolism EcolC_3297 b0326 yahL predicted protein - - -0.19 -0.26 -0.27 -0.34 0.249 EcolC_3298 b0325 yahK predicted oxidoreductase, Zn-dependent POORLY General -0.44 -0.32 -0.39 -0.27 0.995 and NAD(P)-binding CHARACTERIZ function ED prediction EcolC_3299 b0324 yahJ predicted deaminase with metallo- METABOLISM Nucleotidel 0.03 -0.06 -0.08 -0.17 0.809 dependent hydrolase domain transport and metabolism EcolC_3300 b0323 yahI carbamate kinase-like protein METABOLISM Amino acid -0.28 -0.05 -0.20 0.03 0.268 transport and metabolism EcolC_3302 b0321 yahG conserved protein - - -0.19 -0.13 -0.25 -0.18 0.756 EcolC_3303 b0320 yahF predicted acyl-CoA synthetase with METABOLISM Energy -0.26 -0.23 -0.31 -0.27 0.950 NAD(P)-binding domain and succinyl-CoA production synthetase domain and conversion EcolC_3304 b0319 yahE predicted protein - - -0.14 -0.21 -0.20 -0.27 0.716 EcolC_3305 b0318 yahD ankyrin repeat protein POORLY General -0.44 -0.38 -0.32 -0.25 0.821 CHARACTERIZ function ED prediction EcolC_3306 b0317 yahC predicted inner membrane protein - -l 0.00 -0.07 0.07 0.00 0.968 EcolC_3307 b0316 yahB predicted DNA-bindng transcriptional INFORMATION Transcription -0.15 0.07 -0.42 -0.21 0.274 regulator STORAGE AND PROCESSING EcolC_3308 b0315 yahA c-di-GMP-specific phosphodiesterase CELLULAR Signal -0.40 -0.14 -0.22 0.05 0.108 PROCESSES transduction AND mechanisms SIGNALING EcolC_3309 b0314 betT choline transporter of high affinity CELLULAR Cell -0.01 -0.49 -0.22 -0.70 0.017 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3310 b0313 betI DNA-binding transcriptional repressor INFORMATION Transcription 0.95 -0.69 -0.14 -1.78 0.006 STORAGE AND PROCESSING EcolC_3311 b0312 betB betaine aldehyde dehydrogenase, NAD- METABOLISM Energy 0.55 -0.65 -0.12 -1.31 0.007 dependent production and conversion EcolC_3312 b0311 betA choline dehydrogenase, a flavoprotein METABOLISM Amino acid 0.14 -0.25 -0.26 -0.65 0.087 transport and metabolism EcolC_3313 b0310 ykgH predicted inner membrane protein - - -0.25 -0.29 -0.16 -0.20 0.602 EcolC_3314 b0308 ykgG predicted transporter POORLY Function 1.51 0.92 -0.34 -0.93 0.107 CHARACTERIZ unknown ED EcolC_3315 b0307 ykgF predicted electron transport protein with METABOLISM Energy 1.41 0.91 -0.28 -0.78 0.066 ferridoxin-like domai production and conversion EcolC_3316 b0306 ykgE predicted oxidoreductase METABOLISM Energy 2.12 1.43 -0.35 -1.04 0.120 production and conversion EcolC_3317 b0305 ykgD predicted DNA-binding transcriptional INFORMATION Transcription -0.25 -0.18 -0.22 -0.15 0.826 regulator STORAGE AND PROCESSING EcolC_3318 b0304 ykgC predicted pyridine nucleotide-disulfide METABOLISM Energy -0.49 -0.62 -0.21 -0.34 0.467 oxidoreductase production and conversion EcolC_3319 b0301 ykgB inner membrane protein, DUF417 family POORLY Function -0.26 -0.36 -0.36 -0.46 0.738 CHARACTERIZ unknown ED EcolC_3321 b0300 ykgA - - - -0.17 -0.28 -0.37 -0.48 0.430 EcolC_3322 b0297 eaeH - - - -0.40 -0.44 -0.46 -0.50 0.903 EcolC_3323 b0296 ykgM 50S ribosomal protein L31 type B; INFORMATION Translation, -0.05 -0.08 -0.03 -0.05 0.821 alternative L31 utilized during zinc STORAGE AND ribosomal limitation PROCESSING structure and biogenesis EcolC_3324 b4506 ykgO RpmJ-like protein INFORMATION Translation, -0.02 0.03 -0.02 0.03 0.869 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3325 b0294 ecpR predicted regulator INFORMATION Transcription -0.17 -0.27 -0.26 -0.36 0.417 STORAGE AND PROCESSING EcolC_3326 b0293 ecpA cryptic Mat fimbrillin gene - - -0.28 -0.30 -0.23 -0.25 0.979 EcolC_3327 b0292 ecpB predicted protein - - -0.28 -0.19 -0.17 -0.09 0.953 EcolC_3328 b0291 ecpC predicted aromatic compound dioxygenase CELLULAR Cell motility -0.27 -0.14 -0.26 -0.14 0.732 PROCESSES AND SIGNALING EcolC_3329 b0290 ecpD predicted receptor - - -0.16 -0.27 -0.21 -0.32 0.479 EcolC_3330 b0289 ecpE conserved protein - - -0.22 -0.14 -0.37 -0.29 0.743 EcolC_3331 b0288 ykgJ UPF0153 cysteine cluster protein, function POORLY General -0.15 -0.20 -0.07 -0.12 0.657 unknown CHARACTERIZ function ED prediction EcolC_3332 b0287 yagU inner membrane protein, DUF1440 family POORLY Functionl -1.14 -1.18 0.18 0.14 0.770 CHARACTERIZ unknown ED EcolC_3333 b0286 paoA PaoABC aldehyde oxidoreductase, 2Fe-2S METABOLISM Energy -0.25 -0.17 -0.25 -0.17 0.651 subunit production and conversion EcolC_3334 b0285 paoB PaoABC aldehyde oxidoreductase, FAD- METABOLISM Energy -0.14 -0.16 -0.07 -0.10 0.797 containing subunit production and conversion EcolC_3335 b0284 paoC PaoABC aldehyde oxidoreductase, Moco- METABOLISM Energy -0.32 -0.23 -0.17 -0.08 0.844 containing subunit production and conversion EcolC_3336 b0283 paoD moco insertion factor for PaoABC CELLULAR Posttranslatio -0.18 0.04 -0.01 0.21 0.692 aldehyde oxidoreductase PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3338 b0243 proA gamma-glutamylphosphate reductase METABOLISM Amino acid -0.41 -0.39 -0.41 -0.39 0.569 transport and metabolism EcolC_3339 b0242 proB gamma-glutamate kinase METABOLISM Amino acid -0.06 -0.10 -0.23 -0.28 0.975 transport and metabolism EcolC_3340 b0241 phoE outer membrane phosphoporin protein E CELLULAR Cell -0.46 -0.23 -0.24 -0.01 0.475 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3341 b0240 crl - - - -0.10 -0.36 -0.15 -0.41 0.251 EcolC_3342 b0239 frsA fermentation-respiration switch protein; METABOLISM Secondary 0.01 0.42 -0.19 0.22 0.043 PTS Enzyme IIA(Glc)-binding protein; metabolites pNP-butyrate esterase activity biosynthesis, transport and catabolism EcolC_3343 b0238 gpt guanine-hypoxanthine METABOLISM Nucleotide -0.24 -0.23 -0.15 -0.14 0.947 phosphoribosyltransferase transport and metabolism EcolC_3344 b0237 pepD aminoacyl-histidine dipeptidase (peptidase METABOLISM Amino acid -0.55 -0.21 -0.25 0.09 0.263 D) transport and metabolism EcolC_3348 b0232 yafN antitoxin of the YafO-YafN toxin-antitoxin CELLULAR Cell cycle -0.10 0.13 -0.09 0.14 0.970 system PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3349 b0231 dinB DNA polymerase IV INFORMATION Replication, 0.03 -0.11 -0.18 -0.32 0.731 STORAGE AND recombination PROCESSING and repair EcolC_3350 b0230 lafU - - - -0.19 -0.22 -0.16 -0.19 0.968 EcolC_3392 b0228 rayT RAYT REP element-mobilizing INFORMATION Replication, -0.27 -0.16 -0.23 -0.11 0.399 transposase; TnpA(REP) STORAGE AND recombination PROCESSING and repair EcolC_3394 b0226 dinJ antitoxin of YafQ-DinJ toxin-antitoxin INFORMATION Replication, 0.41 0.25 0.29 0.13 0.841 system STORAGE AND recombination PROCESSING and repair EcolC_3395 b0225 yafQ translation inhibitor toxin of toxin- POORLY Function -0.32 -0.18 -0.32 -0.18 0.333 antitoxin pair YafQ/DinJ CHARACTERIZ unknown ED EcolC_3396 b0224 yafK conserved protein POORLY Function -0.57 -0.38 0.01 0.20 0.274 CHARACTERIZ unknown ED EcolC_3397 b0223 yafJ predicted amidotransfease POORLY General -0.52 -0.34 -0.41 -0.22 0.571 CHARACTERIZ function ED prediction EcolC_3398 b0222 gmhA D-sedoheptulose 7-phosphate isomerase METABOLISM Carbohydratel -0.32 -0.50 -0.46 -0.63 0.910 transport and metabolism EcolC_3399 b0221 fadE acyl coenzyme A dehydrogenase METABOLISM Lipid 0.61 -0.26 -0.21 -1.08 0.028 transport and metabolism EcolC_3400 b0220 ivy inhibitor of c-type lysozyme, periplasmic - - -0.22 -0.15 -0.34 -0.28 0.287 EcolC_3407 b4505 insX - - - -0.03 0.24 0.21 0.48 0.084 EcolC_3407 b4561 insM - - - 0.23 0.33 0.22 0.32 0.631 EcolC_3408 b1404 insI1 IS30 transposase INFORMATION Replication, 0.63 0.33 -0.08 -0.38 0.575 STORAGE AND recombination PROCESSING and repair EcolC_3450 b0215 dnaQ DNA polymerase III epsilon subunit INFORMATION Replication, 0.05 0.03 -0.28 -0.31 0.917 STORAGE AND recombination PROCESSING and repair EcolC_3451 b0214 rnhA ribonuclease HI, degrades RNA of DNA- INFORMATION Replication, -0.19 -0.04 0.04 0.18 0.373 RNA hybrids STORAGE AND recombination PROCESSING and repair EcolC_3452 b0213 yafS predicted S-adenosyl-L-methionine- METABOLISM Coenzyme -0.37 -0.24 -0.02 0.10 0.292 dependent methyltransferase transport and metabolism EcolC_3453 b0212 gloB hydroxyacylglutathione hydrolase POORLY General -0.47 -0.14 -0.14 0.20 0.205 CHARACTERIZ function ED prediction EcolC_3454 b0211 mltD predicted membrane-bound lytic murein CELLULAR Celll -0.32 -0.25 -0.06 0.01 0.347 transglycosylase D PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3455 b0210 yafE predicted S-adenosyl-L-methionine- METABOLISM Coenzyme -0.42 -0.29 -0.17 -0.03 0.703 dependent methyltransferase transport and metabolism EcolC_3456 b0209 yafD conserved protein POORLY Function -0.23 -0.21 -0.01 0.01 0.794 CHARACTERIZ unknown ED EcolC_3457 b0208 yafC predicted DNA-binding transcriptional INFORMATION Transcription -0.24 -0.22 -0.14 -0.12 0.619 regulator STORAGE AND PROCESSING EcolC_3458 b0207 dkgB 2,5-diketo-D-gluconate reductase B POORLY General -0.13 -0.11 -0.08 -0.06 0.930 CHARACTERIZ function ED prediction l EcolC_3459 b0200 gmhB D,D-heptose 1,7-bisphosphate phosphatase METABOLISM Amino acid -0.07 0.12 -0.22 -0.03 0.443 transport and metabolism EcolC_3460 b0199 metN DL-methionine transporter subunit METABOLISM Inorganic ion -0.20 -0.29 -0.18 -0.27 0.888 transport and metabolism EcolC_3461 b0198 metI DL-methionine transporter subunit METABOLISM Inorganic ion -0.24 -0.21 -0.24 -0.20 0.753 transport and metabolism EcolC_3462 b0197 metQ DL-methionine transporter subunit METABOLISM Inorganic ion -0.53 -0.47 -0.43 -0.37 0.851 transport and metabolism EcolC_3463 b0196 rcsF predicted outer membrane protein, signal - - -0.91 -0.42 -0.37 0.11 0.101 EcolC_3464 b0195 tsaA tRNA-Thr(GGU) m(6)t(6)A37 POORLY Function 0.06 0.00 0.14 0.09 0.927 methyltransferase, SAM-dependent CHARACTERIZ unknown ED EcolC_3465 b0194 proS prolyl-tRNA synthetase INFORMATION Translation, -0.25 -0.46 -0.40 -0.61 0.372 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3466 b0193 yaeF predicted lipoprotein CELLULAR Cell -0.15 -0.21 -0.12 -0.18 0.430 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3468 b0191 arfB alternative stalled-ribosome rescue factor INFORMATION Translation, 0.09 0.01 -0.20 -0.29 0.929 B; peptidyl-tRNA hydrolase, ribosome- STORAGE AND ribosomal attached PROCESSING structure and biogenesis EcolC_3469 b0190 yaeQ conserved protein POORLY Function -0.18 -0.20 -0.24 -0.26 0.970 CHARACTERIZ unknown ED EcolC_3470 b4406 yaeP conserved protein - - -0.54 -0.71 -0.09 -0.26 0.398 EcolC_3471 b0189 rof modulator of Rho-dependent transcription INFORMATION Transcription -0.58 -0.48 -0.24 -0.14 0.961 termination STORAGE AND PROCESSING EcolC_3472 b0188 tilS tRNA(Ile)-lysidine synthetase CELLULAR Cell cycle 0.10 -0.29 -0.20 -0.59 0.279 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3473 b0187 yaeR predicted lyase METABOLISM Amino acid -0.51 -0.69 -0.14 -0.33 0.006 transport and metabolism EcolC_3474 b0186 ldcC lysine decarboxylase 2, constitutive METABOLISM Amino acid -0.88 -1.16 -0.04 -0.32 0.107 transport and metabolism EcolC_3475 b0185 accA acetyl-CoA carboxylase, METABOLISM Lipid -0.91 -0.57 -0.31 0.04 0.132 carboxytransferase, alpha subunit transport and metabolism EcolC_3476 b0184 dnaE DNA polymerase III alpha subunit INFORMATION Replication, -0.25 -0.21 -0.20 -0.16 0.791 STORAGE AND recombination PROCESSING and repair EcolC_3477 b0183 rnhB ribonuclease HII, degrades RNA of DNA- INFORMATION Replication, 0.40 0.25 0.52 0.37 0.961 RNA hybrids STORAGE AND recombination PROCESSING and repair EcolC_3478 b0182 lpxB tetraacyldisaccharide-1-P synthase CELLULAR Cell -0.24 -0.29 -0.20 -0.25 0.594 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3479 b0181 lpxA UDP-N-acetylglucosamine CELLULAR Cell -0.23 -0.08 -0.12 0.03 0.575 acetyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3480 b0180 fabZ (3R)-hydroxymyristol acyl carrier protein METABOLISM Lipid -0.44 -0.23 -0.13 0.08 0.030 dehydratase transport and metabolism EcolC_3481 b0179 lpxD UDP-3-O-(3-hydroxymyristoyl)- CELLULAR Cell -1.26 -0.64 -0.14 0.48 0.013 glucosamine N-acyltransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3482 b0178 skp periplasmic chaperone CELLULAR Cell -0.95 -0.78 -0.06 0.11 0.278 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3483 b0177 bamA outer membrane protein assembly factor, CELLULAR Cell -1.16 -0.83 -0.27 0.07 0.053 forms pores; required for OM biogenesis; PROCESSES wall/membran in BamABCDE OM protein complex AND e/envelope SIGNALING biogenesis EcolC_3484 b0176 rseP inner membrane zinc RIP metalloprotease; CELLULAR Cell -0.09 -0.29 -0.01 -0.22 0.103 RpoE activator, by degrading RseA; PROCESSES wall/membran cleaved signal peptide endoprotease AND e/envelope SIGNALING biogenesis EcolC_3485 b0175 cdsA CDP-diglyceride synthase METABOLISM Lipid 0.07 -0.12 -0.21 -0.40 0.138 transport and metabolism EcolC_3486 b0174 ispU undecaprenyl pyrophosphate synthase METABOLISM Lipid -0.12 -0.22 -0.19 -0.29 0.569 transport and metabolism EcolC_3487 b0173 dxr 1-deoxy-D-xylulose 5-phosphate METABOLISM Lipid -0.29 -0.35 -0.14 -0.20 0.373 reductoisomerase transport and metabolism EcolC_3488 b0172 frr ribosome recycling factor INFORMATION Translation, -0.60 -0.77 -0.03 -0.21 0.264 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3489 b0171 pyrH uridylate kinase METABOLISM Nucleotide -0.18 -0.24 -0.16 -0.23 0.606 transport and metabolism EcolC_3490 b0170 tsf protein chain elongation factor EF-Ts INFORMATION Translation, -1.64 -1.44 -0.24 -0.03 0.084 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3491 b0169 rpsB 30S ribosomal subunit protein S2 INFORMATION Translation, -1.90 -1.56 -0.09 0.25 0.175 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3492 b0168 map methionine aminopeptidase INFORMATION Translation, 0.03 -0.04 -0.17 -0.23 0.346 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3493 b0167 glnD uridylyltransferase CELLULAR Posttranslatio 0.21 0.16 -0.21 -0.25 0.902 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3494 b0166 dapD 2,3,4,5-tetrahydropyridine-2-carboxylate METABOLISM Amino acid -0.13 -0.16 -0.03 -0.06 0.998 N-succinyltransferase transport and metabolism EcolC_3495 b0164 yaeI phosphodiesterase with model substrate POORLY General -0.19 0.07 -0.02 0.25 0.289 bis-pNPP CHARACTERIZ function ED prediction EcolC_3496 b0163 yaeH conserved protein, UPF0325 family - -l 0.08 0.38 0.14 0.44 0.213 EcolC_3497 b0162 cdaR DNA-binding transcriptional regulator for INFORMATION Transcription -1.91 -1.67 -0.52 -0.28 0.368 gar and gud operons; carbohydrate diacid STORAGE AND regulator PROCESSING EcolC_3498 b0161 degP serine endoprotease (protease Do), CELLULAR Posttranslatio 0.51 -0.48 -0.16 -1.15 0.014 membrane-associated PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3499 b0160 dgt deoxyguanosine triphosphate METABOLISM Nucleotide -0.42 -0.51 -0.27 -0.36 0.962 triphosphohydrolase transport and metabolism EcolC_3500 b0159 mtn 5'-methylthioadenosine/S- METABOLISM Nucleotide 0.00 0.13 -0.22 -0.09 0.472 adenosylhomocysteine nucleosidase transport and metabolism EcolC_3501 b0158 btuF vitamin B12 transporter subunit: METABOLISM Inorganic ion -0.04 -0.12 -0.23 -0.31 0.493 periplasmic-binding component of ABC transport and superfamily metabolism EcolC_3502 b0157 yadS inner membrane protein, UPF0126 family POORLY Function -0.22 -0.40 -0.28 -0.45 0.060 CHARACTERIZ unknown ED EcolC_3503 b0156 erpA iron-sulfur cluster insertion protein POORLY Function 0.17 -0.13 -0.14 -0.44 0.039 CHARACTERIZ unknown ED EcolC_3504 b0155 clcA H(+)/Cl(-) exchange transporter METABOLISM Inorganic ion -0.03 -0.55 -0.27 -0.78 0.006 transport and metabolism EcolC_3505 b0154 hemL glutamate-1-semialdehyde METABOLISM Coenzyme 1.00 0.41 -0.20 -0.79 0.005 aminotransferase (aminomutase) transport and metabolism EcolC_3506 b0153 fhuB fused iron-hydroxamate transporter METABOLISM Inorganic ion -0.25 -0.31 -0.20 -0.26 0.536 subunits of ABC superfamily: membrane transport and components metabolism EcolC_3507 b0152 fhuD iron-hydroxamate transporter subunit METABOLISM Inorganic ion -0.30 -0.45 -0.35 -0.51 0.129 transport and metabolism EcolC_3508 b0151 fhuC iron-hydroxamate transporter subunit METABOLISM Inorganic ion -0.43 -0.44 -0.28 -0.30 0.714 transport and metabolism EcolC_3509 b0150 fhuA ferrichrome outer membrane transporter METABOLISM Inorganic ion -0.42 -0.55 -0.30 -0.43 0.373 transport and metabolism EcolC_3510 b0149 mrcB fused glycosyl transferase and CELLULAR Cell -0.06 -0.16 -0.24 -0.34 0.162 transpeptidase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3511 b0148 hrpB predicted ATP-dependent helicase INFORMATION Replication, 0.12 -0.06 -0.10 -0.28 0.324 STORAGE AND recombination PROCESSING and repair EcolC_3512 b0147 ligT 2'-5' RNA ligase INFORMATION Translation, -0.49 -0.38 -0.18 -0.07 0.410 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3513 b0146 sfsA predicted DNA-binding transcriptional POORLY General -0.73 -0.22 0.24 0.75 0.099 regulator CHARACTERIZ function ED prediction EcolC_3514 b0145 dksA DNA-binding transcriptional regulator of CELLULAR Signall -1.17 -0.79 0.47 0.84 0.063 rRNA transcription, DnaK suppressor PROCESSES transduction protein AND mechanisms SIGNALING EcolC_3515 b0144 gluQ glutamyl-Q tRNA(Asp) synthetase INFORMATION Translation, -0.24 -0.14 -0.03 0.07 0.260 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3516 b0143 pcnB poly(A) polymerase INFORMATION Translation, -0.29 -0.29 -0.29 -0.29 0.783 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3517 b0142 folK 2-amino-4-hydroxy-6- METABOLISM Coenzyme -0.37 -0.31 -0.23 -0.17 0.983 hydroxymethyldihyropteridine transport and pyrophosphokinase metabolism EcolC_3525 b0134 panB 3-methyl-2-oxobutanoate METABOLISM Coenzyme -0.46 -0.45 -0.21 -0.21 0.751 hydroxymethyltransferase transport and metabolism EcolC_3526 b0133 panC pantothenate synthetase METABOLISM Coenzyme -0.40 -0.29 -0.32 -0.21 0.448 transport and metabolism EcolC_3527 b0132 yadD predicted transposase POORLY Function -0.41 -0.25 -0.06 0.10 0.620 CHARACTERIZ unknown ED EcolC_3528 b0131 panD aspartate 1-decarboxylase METABOLISM Coenzyme -0.24 -0.45 -0.18 -0.39 0.412 transport and metabolism EcolC_3529 b0130 yadE predicted polysaccharide deacetylase METABOLISM Carbohydrate -0.29 -0.16 -0.16 -0.03 0.292 lipoprotein transport and metabolism EcolC_3530 b0129 yadI predicted PTS Enzyme IIA METABOLISM Carbohydrate -0.42 0.02 -0.14 0.29 0.555 transport and metabolism EcolC_3531 b0128 yadH predicted transporter subunit: membrane METABOLISM Carbohydrate -0.45 -0.60 -0.45 -0.59 0.510 component of ABC superfamily transport and metabolism EcolC_3532 b0127 yadG predicted transporter subunit: ATP-binding CELLULAR Defense -0.05 -0.45 -0.36 -0.75 0.071 component of ABC superfamily PROCESSES mechanisms AND SIGNALING EcolC_3533 b0126 can carbonic anhydrase METABOLISM Inorganic ion -0.76 -0.54 -0.19 0.03 0.060 transport and metabolism EcolC_3534 b0125 hpt hypoxanthine phosphoribosyltransferase METABOLISM Nucleotide -0.21 -0.33 -0.19 -0.31 0.527 transport and metabolism EcolC_3535 b0124 gcd glucose dehydrogenase METABOLISM Carbohydrate -0.40 -0.46 -0.26 -0.32 0.665 transport and metabolism EcolC_3536 b0123 cueO multicopper oxidase (laccase) METABOLISM Secondary -0.22 -0.22 -0.34 -0.34 0.937 metabolites biosynthesis, transport and catabolism EcolC_3537 b0122 yacC conserved protein, PulS_OutS family - - -0.56 -0.35 -0.28 -0.07 0.441 EcolC_3538 b0121 speE spermidine synthase (putrescine METABOLISM Amino acid -0.78 -0.61 -0.28 -0.12 0.169 aminopropyltransferase) transport and metabolism EcolC_3539 b0120 speD S-adenosylmethionine decarboxylase METABOLISM Amino acid -0.48 -0.30 -0.28 -0.10 0.346 transport and metabolism EcolC_3540 b0119 yacL conserved protein POORLY Function 0.19 0.21 0.01 0.03 0.741 CHARACTERIZ unknown ED EcolC_3541 b0118 acnB bifunctional aconitate hydratase 2/2- METABOLISM Energy 0.15 -0.72 -0.25 -1.12 0.006 methylisocitrate dehydratase production and conversion EcolC_3542 b0117 yacH predicted protein - - -0.24 -0.33 -0.04 -0.13 0.229 EcolC_3543 b0116 lpd lipoamide dehydrogenase, E3 component is METABOLISM Energy 0.80 -0.24 -0.27 -1.31 0.001 part of three enzyme complexes production and conversion EcolC_3544 b0115 aceF pyruvate dehydrogenase, METABOLISM Energy 0.37 -0.23 -0.61 -1.21 0.009 dihydrolipoyltransacetylase component E2 production and conversion EcolC_3545 b0114 aceE pyruvate dehydrogenase, decarboxylase METABOLISM Energy 1.00 -0.35 -0.45 -1.79 0.000 component E1, thiamin-binding production and conversion EcolC_3546 b0113 pdhR DNA-binding transcriptional dual regulator INFORMATION Transcription -0.10 -0.15 -0.12 -0.18 0.863 STORAGE AND PROCESSING EcolC_3547 b0112 aroP aromatic amino acid transporter METABOLISM Amino acid -0.20 -0.31 -0.08 -0.19 0.367 transport and metabolism EcolC_3548 b0111 ampE predicted inner membrane protein CELLULAR Defense -0.43 -0.23 -0.39 -0.18 0.027 PROCESSES mechanisms AND SIGNALING EcolC_3549 b0110 ampD 1,6-anhydro-N-acetylmuramyl-L-alanine CELLULAR Defense -0.20 -0.26 -0.22 -0.28 0.839 amidase, Zn-dependent; murein amidase PROCESSES mechanisms AND SIGNALING EcolC_3550 b0109 nadC quinolinate phosphoribosyltransferase METABOLISM Coenzyme -0.30 -0.24 -0.02 0.04 0.589 transport and metabolism EcolC_3551 b0108 ppdD predicted major pilin subunit CELLULAR Cell motility -0.21 -0.09 -0.13 -0.01 0.399 PROCESSES AND SIGNALING EcolC_3552 b0107 hofB conserved protein with nucleoside CELLULAR Cell motility -0.10 0.02 -0.25 -0.12 0.406 triphosphate hydrolase domain PROCESSES AND SIGNALING EcolC_3553 b0106 hofC assembly protein in type IV pilin CELLULAR Cell motility -0.24 -0.29 -0.22 -0.26 0.777 biogenesis, transmembrane protein PROCESSES AND SIGNALING EcolC_3554 b0104 guaC GMP reductase METABOLISM Nucleotide -0.35 -0.21 -0.20 -0.06 0.767 transport and metabolism EcolC_3555 b0103 coaE dephospho-CoA kinase METABOLISM Coenzyme 0.04 -0.19 -0.15 -0.38 0.036 transport and metabolism EcolC_3556 b0102 zapD FtsZ stabilizer POORLY Function 0.08 -0.12 -0.03 -0.23 0.535 CHARACTERIZ unknown ED EcolC_3557 b0101 yacG DNA gyrase inhibitor POORLY Function 0.03 -0.16 -0.24 -0.43 0.123 CHARACTERIZ unknown ED EcolC_3558 b0099 mutT nucleoside triphosphate METABOLISM Nucleotide 0.03 -0.11 -0.15 -0.29 0.874 pyrophosphohydrolase, marked preference transport and for dGTP metabolism EcolC_3559 b0098 secA preprotein translocase subunit, ATPase CELLULAR Intracellular 0.28 -0.07 -0.31 -0.67 0.048 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_3560 b0097 secM regulator of secA translation - - 0.18 -0.22 -0.30 -0.69 0.057 EcolC_3561 b0096 lpxC UDP-3-O-acyl N-acetylglucosamine CELLULAR Cell 0.57 -0.15 -0.31 -1.03 0.012 deacetylase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3562 b0095 ftsZ GTP-binding tubulin-like cell division CELLULAR Cell cycle -0.04 -0.67 -0.18 -0.80 0.005 protein PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3563 b0094 ftsA ATP-binding cell division protein CELLULAR Cell cycle -0.03 -0.22 -0.08 -0.27 0.246 involved in recruitment of FtsK to Z PROCESSES control, cell ring AND division, SIGNALING chromosome partitioning EcolC_3564 b0093 ftsQ divisome assembly protein, membrane CELLULAR Cell -0.14 0.16 -0.02 0.29 0.272 anchored protein involved in growth of PROCESSES wall/membran wall at septum AND e/envelope SIGNALING biogenesis EcolC_3565 b0092 ddlB D-alanine:D-alanine ligase CELLULAR Cell 0.44 0.27 -0.10 -0.27 0.349 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3566 b0091 murC UDP-N-acetylmuramate:L-alanine ligase CELLULAR Cell 0.12 0.16 -0.04 0.00 0.469 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3567 b0090 murG N-acetylglucosaminyl transferase CELLULAR Cell 0.24 -0.16 0.04 -0.35 0.005 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3568 b0089 ftsW lipid II flippase; integral membrane protein CELLULAR Cell cycle 0.55 0.19 0.06 -0.30 0.054 involved in stabilizing FstZ ring during cell PROCESSES control, cell division AND division, SIGNALING chromosome partitioning EcolC_3569 b0088 murD UDP-N-acetylmuramoyl-L-alanine:D- CELLULAR Cell -0.03 -0.25 -0.19 -0.40 0.650 glutamate ligase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3570 b0087 mraY phospho-N-acetylmuramoyl-pentapeptide CELLULAR Cell 0.27 0.38 -0.15 -0.04 0.552 transferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3571 b0086 murF UDP-N-acetylmuramoyl-tripeptide:D- CELLULAR Cell -0.10 0.03 -0.31 -0.18 0.409 alanyl-D- alanine ligase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3572 b0085 murE UDP-N-acetylmuramoyl-L-alanyl-D- CELLULAR Cell 0.10 0.15 -0.31 -0.26 0.349 glutamate:meso- diaminopimelate ligase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3573 b0084 ftsI transpeptidase involved in septal CELLULAR Cell 0.32 0.19 -0.24 -0.37 0.748 peptidoglycan synthesis (penicillin-binding PROCESSES wall/membran protein 3) AND e/envelope SIGNALING biogenesis EcolC_3574 b0083 ftsL membrane bound cell division protein at CELLULAR Cell cycle 0.68 0.91 0.04 0.28 0.154 septum containing leucine zipper motif PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3575 b0082 rsmH 16S rRNA m(4)C1402 methyltransferase, CELLULAR Cell 0.11 0.12 -0.07 -0.06 0.869 SAM-dependent PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3576 b0081 mraZ RsmH methytransferase inhibitor POORLY Function 0.10 0.09 0.07 0.06 0.851 CHARACTERIZ unknown ED EcolC_3577 b0080 cra DNA-binding transcriptional repressor- INFORMATION Transcription 0.52 -0.11 -0.15 -0.78 0.079 activator for carbon metabolism STORAGE AND PROCESSING EcolC_3579 b0078 ilvH acetolactate synthase III, thiamin- METABOLISM Amino acid -0.25 -0.09 -0.14 0.03 0.223 dependent, small subunit transport and metabolism EcolC_3580 b0077 ilvI acetolactate synthase III, large subunit METABOLISM Amino acid -0.27 -0.28 -0.01 -0.02 0.923 transport and metabolism EcolC_3581 b0076 leuO DNA-binding transcriptional activator INFORMATION Transcription -0.25 -0.19 -0.10 -0.04 0.868 STORAGE AND PROCESSING EcolC_3582 b0075 leuL leu operon leader peptide - - -0.48 -0.75 -0.43 -0.70 0.280 EcolC_3583 b0074 leuA 2-isopropylmalate synthase METABOLISM Amino acid 0.04 -0.16 -0.06 -0.26 0.753 transport and metabolism EcolC_3584 b0073 leuB 3-isopropylmalate dehydrogenase, METABOLISM Energy -0.33 -0.45 -0.18 -0.30 0.657 NAD(+)-dependent production and conversion EcolC_3585 b0072 leuC 3-isopropylmalate dehydratase large METABOLISM Amino acid -0.13 -0.21 -0.20 -0.27 0.339 subunit transport and metabolism EcolC_3586 b0071 leuD 3-isopropylmalate dehydratase small METABOLISM Amino acid -0.29 -0.20 -0.27 -0.19 0.849 subunit transport and metabolism EcolC_3587 b0070 setA broad specificity sugar efflux system METABOLISM Carbohydrate -0.28 -0.41 -0.20 -0.33 0.971 transport and metabolism EcolC_3588 b0069 sgrR transcriptional DNA-binding POORLY General -0.11 -0.24 -0.13 -0.26 0.429 transcriptional activator of sgrS sRNA CHARACTERIZ function ED prediction EcolC_3590 b0067 thiP fused thiamin transporter subunits of ABC METABOLISM Inorganicl ion -0.27 -0.19 -0.22 -0.14 0.576 superfamily: membrane components transport and metabolism EcolC_3591 - thiQ thiamine transporter ATP-binding subunit METABOLISM Coenzyme -0.15 -0.07 0.11 0.19 0.678 transport and metabolism EcolC_3592 b0065 yabI inner membrane protein, SNARE_assoc POORLY Function -0.16 -0.77 0.81 0.20 0.048 family CHARACTERI unknown ZED EcolC_3593 b0064 araC DNA-binding transcriptional dual INFORMATIO Transcriptio 0.19 0.20 0.01 0.03 0.937 regulator N STORAGE n AND PROCESSING EcolC_3594 b0063 araB L-ribulokinase METABOLISM Energy -0.37 -0.21 -0.21 -0.04 0.423 production and conversion EcolC_3596 b0061 araD L-ribulose-5-phosphate 4-epimerase METABOLISM Carbohydrate -0.07 -0.08 -0.03 -0.04 0.644 transport and metabolism EcolC_3597 b0060 polB DNA polymerase II INFORMATION Replication, -0.19 -0.04 -0.07 0.08 0.475 STORAGE AND recombination PROCESSING and repair EcolC_3598 b0059 rapA RNA polymerase remodeling/recycling INFORMATION Transcription -0.21 -0.16 -0.21 -0.16 0.789 factor ATPase; RNA polymerase- STORAGE AND associated, ATP-dependent RNA PROCESSING translocase EcolC_3599 b0058 rluA dual specificity 23S rRNA INFORMATION Translation, -0.15 -0.07 0.10 0.19 0.311 pseudouridine(746), tRNA STORAGE AND ribosomal pseudouridine(32) synthase, SAM- PROCESSING structure and dependent biogenesis EcolC_3600 b0055 djlA DnaJ-like protein, membrane anchored CELLULAR Posttranslatio -0.08 -0.16 -0.02 -0.11 0.529 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3601 b0054 lptD LPS assembly OM complex LptDE, beta- CELLULAR Cell -0.05 -0.19 0.02 -0.12 0.293 barrel component PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3602 b0053 surA peptidyl-prolyl cis-trans isomerase (PPIase) CELLULAR Posttranslatio -0.10 -0.16 -0.11 -0.17 0.716 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3604 b0051 rsmA 16S rRNA m(6)A1518, m(6)A1519 INFORMATION Translation, -0.27 -0.20 -0.19 -0.12 0.884 dimethyltransferase, SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3605 b0050 apaG protein associated with Co2+ and Mg2+ METABOLISM Inorganic ion -0.17 -0.25 -0.08 -0.16 0.796 efflux transport and metabolism EcolC_3606 b0049 apaH diadenosine tetraphosphatase CELLULAR Signal -0.49 -0.45 -0.01 0.03 0.868 PROCESSES transduction AND mechanisms SIGNALING EcolC_3607 b0048 folA dihydrofolate reductase METABOLISM Coenzyme -0.27 -0.46 -0.14 -0.34 0.047 transport and metabolism EcolC_3608 b0047 kefC potassium:proton antiporter METABOLISM Inorganic ion -0.03 -0.11 0.00 -0.08 0.899 transport and metabolism EcolC_3609 b0046 kefF potassium-efflux system ancillary protein POORLY General 0.16 -0.28 -0.25 -0.69 0.103 for KefC, glutathione-regulated; quinone CHARACTERIZ function oxidoreductase, FMN-dependent ED prediction EcolC_3610 b0045 yaaU predicted transporter METABOLISM Carbohydratel -0.13 -0.08 -0.13 -0.08 0.962 transport and metabolism EcolC_3611 b0044 fixX predicted 4Fe-4S ferredoxin-type protein METABOLISM Energy -0.36 -0.34 -0.21 -0.19 0.943 production and conversion EcolC_3612 b0043 fixC predicted oxidoreductase with METABOLISM Energy -0.01 -0.15 -0.22 -0.37 0.528 FAD/NAD(P)-binding domain production and conversion EcolC_3613 b0042 fixB predicted electron transfer flavoprotein, METABOLISM Energy -0.14 -0.13 -0.18 -0.16 0.830 NAD/FAD-binding domain and ETFP production adenine nucleotide-binding domain-like and protein conversion EcolC_3614 b0041 fixA predicted electron transfer flavoprotein METABOLISM Energy -0.02 -0.05 -0.17 -0.20 0.537 subunit, required for anaerobic carnitine production reduction and conversion EcolC_3615 b0040 caiT predicted transporter CELLULAR Cell -0.22 -0.31 -0.53 -0.61 0.791 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3616 b0039 caiA crotonobetaine reductase subunit II, FAD- METABOLISM Lipid -0.26 -0.19 -0.21 -0.15 0.745 binding transport and metabolism EcolC_3617 b0038 caiB crotonobetainyl CoA:carnitine CoA METABOLISM Energy -0.17 0.12 -0.17 0.12 0.175 transferase production and conversion EcolC_3618 b0037 caiC probable crotonobetaine/carnitine-CoA METABOLISM Lipid -0.18 -0.27 -0.29 -0.38 0.770 ligase transport and metabolism EcolC_3620 b0035 caiE stimulator of CaiD and CaiB enzyme POORLY General -0.24 -0.20 -0.03 0.00 0.443 activities CHARACTERIZ function ED prediction EcolC_3621 b0034 caiF DNA-binding transcriptional activator - -l -0.70 0.17 -0.10 0.77 0.022 EcolC_3622 b0033 carB carbamoyl-phosphate synthase large METABOLISM Amino acid -0.26 -0.34 -0.17 -0.25 0.996 subunit transport and metabolism EcolC_3623 b0032 carA carbamoyl phosphate synthetase small METABOLISM Amino acid -0.54 -0.61 -0.42 -0.50 0.625 subunit, glutamine amidotransferase transport and metabolism EcolC_3624 b0031 dapB dihydrodipicolinate reductase METABOLISM Amino acid -0.47 -0.25 -0.19 0.03 0.251 transport and metabolism EcolC_3627 b0028 fkpB FKBP-type peptidyl-prolyl cis-trans CELLULAR Posttranslatio -0.56 -0.51 -0.26 -0.21 0.960 isomerase (rotamase) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3628 b0027 lspA prolipoprotein signal peptidase (signal CELLULAR Cell -0.31 -0.27 -0.21 -0.17 0.909 peptidase II) PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3629 b0026 ileS isoleucyl-tRNA synthetase INFORMATION Translation, -0.39 -0.44 -0.38 -0.43 0.561 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3630 b0025 ribF bifunctional /FAD METABOLISM Coenzyme -0.38 -0.30 -0.29 -0.22 0.836 synthetase transport and metabolism EcolC_3631 b0023 rpsT 30S ribosomal subunit protein S20 INFORMATION Translation, -0.16 -0.18 -0.40 -0.42 0.827 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3636 - - hypothetical protein - - 0.13 -0.12 0.07 -0.18 0.049 EcolC_3637 b0020 nhaR DNA-binding transcriptional activator INFORMATION Transcription 1.18 1.02 0.52 0.36 0.484 STORAGE AND PROCESSING EcolC_3638 b0019 nhaA sodium-proton antiporter METABOLISM Inorganic ion 0.86 0.04 -0.32 -1.14 0.093 transport and metabolism EcolC_3640 b0016 insL1 IS186 transposase INFORMATION Replication, 0.21 0.30 0.04 0.13 0.826 STORAGE AND recombination PROCESSING and repair EcolC_3641 b0015 dnaJ chaperone Hsp40, co-chaperone with DnaK CELLULAR Posttranslatio 0.81 0.61 -0.34 -0.54 0.209 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3642 b0014 dnaK chaperone Hsp70, co-chaperone with DnaJ CELLULAR Posttranslatio 2.30 1.37 -0.28 -1.20 0.080 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3644 b0011 yaaW conserved protein, UPF0174 family POORLY Function -0.26 -0.47 -0.27 -0.49 0.736 CHARACTERIZ unknown ED EcolC_3645 b0010 yaaH inner membrane protein, POORLY Function -0.16 0.17 -0.10 0.23 0.134 Grp1_Fun34_YaaH family CHARACTERIZ unknown ED EcolC_3646 b0009 mog molybdochelatase incorporating METABOLISM Coenzyme -0.23 -0.18 -0.44 -0.39 0.579 molybdenum into molybdopterin transport and metabolism EcolC_3647 b0008 talB transaldolase B METABOLISM Carbohydrate -0.07 -0.14 -0.18 -0.25 0.527 transport and metabolism EcolC_3648 b0007 yaaJ predicted transporter METABOLISM Amino acid -0.37 -0.61 -0.12 -0.36 0.390 transport and metabolism EcolC_3649 b0006 yaaA peroxide resistance protein, lowers POORLY Function -0.29 -0.20 -0.17 -0.08 0.420 intracellular iron CHARACTERIZ unknown ED EcolC_3650 b0005 yaaX predicted protein - - -0.49 -0.58 -0.21 -0.30 0.506 EcolC_3651 b0004 thrC threonine synthase METABOLISM Amino acid -1.81 -1.79 -0.12 -0.11 0.673 transport and metabolism EcolC_3652 b0003 thrB homoserine kinase METABOLISM Amino acid -2.02 -1.92 -0.05 0.04 0.767 transport and metabolism EcolC_3653 b0002 thrA fused aspartokinase I and homoserine METABOLISM Amino acid -1.81 -1.63 -0.14 0.04 0.597 dehydrogenase I transport and metabolism EcolC_3654 b4403 yjtD predicted methyltransferase INFORMATION Translation, 0.35 0.23 0.34 0.22 0.856 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3655 b4401 arcA DNA-binding response regulator in two- CELLULAR Signal -0.37 -0.90 0.30 -0.24 0.005 component regulatory system with ArcB or PROCESSES transduction CpxA AND mechanisms SIGNALING EcolC_3656 b4400 creD inner membrane protein CELLULAR Defense 0.08 0.06 0.04 0.03 0.402 PROCESSES mechanisms AND SIGNALING EcolC_3657 b4399 creC sensory histidine kinase in two-component CELLULAR Signal -0.04 -0.12 0.11 0.03 0.704 regulatory system with CreB or PhoB, PROCESSES transduction regulator of the CreBC regulon AND mechanisms SIGNALING EcolC_3658 b4398 creB DNA-binding response regulator in two- CELLULAR Signal 0.27 0.17 -0.02 -0.12 0.544 component regulatory system with CreC PROCESSES transduction AND mechanisms SIGNALING EcolC_3659 b4397 creA conserved protein POORLY Function 0.11 0.24 0.01 0.14 0.140 CHARACTERI unknown ZED EcolC_3660 b4396 rob right oriC-binding transcriptional INFORMATIO Transcriptio -0.49 -0.04 -2.73 -2.28 0.138 activator, AraC family N STORAGE n AND PROCESSING EcolC_3661 b4395 ytjC phosphatase METABOLISM Carbohydrate 0.24 0.24 0.27 0.28 0.630 transport and metabolism EcolC_3662 b4394 yjjX inosine/xanthosine triphosphatase POORLY Function 0.52 0.21 0.27 -0.04 0.423 CHARACTERIZ unknown ED EcolC_3663 b4393 trpR DNA-binding transcriptional repressor, INFORMATION Transcription 0.45 0.43 0.35 0.33 0.961 tryptophan-binding STORAGE AND PROCESSING EcolC_3664 b4392 slt lytic murein transglycosylase, soluble CELLULAR Cell 0.43 0.23 -0.09 -0.29 0.620 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3665 b4391 yjjK fused predicted transporter subunits of POORLY General -0.10 -0.22 -0.15 -0.27 0.923 ABC superfamily: ATP-binding CHARACTERIZ function components ED prediction EcolC_3666 b4390 nadR trifunctional protein: nicotinamide METABOLISM Coenzymel -0.21 -0.05 0.34 0.50 0.237 mononucleotide adenylyltransferase, transport and ribosylnicotinamide kinase, transcriptional metabolism repressor EcolC_3667 b4389 radA DNA repair protein CELLULAR Posttranslatio 0.13 0.18 0.03 0.08 0.935 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3668 b4388 serB 3-phosphoserine phosphatase METABOLISM Amino acid 0.09 0.05 0.04 0.00 0.773 transport and metabolism EcolC_3669 b4387 ytjB conserved membrane protein POORLY General 0.01 -0.06 -0.10 -0.17 0.496 CHARACTERIZ function ED prediction EcolC_3670 b4386 lplA lipoate-protein ligase A METABOLISM Coenzymel 0.03 0.24 -0.17 0.04 0.343 transport and metabolism EcolC_3671 - - hypothetical protein - - 0.60 0.72 0.25 0.37 0.175 EcolC_3672 b4384 deoD purine-nucleoside phosphorylase METABOLISM Nucleotide 1.62 1.29 -0.29 -0.62 0.099 transport and metabolism EcolC_3673 b4383 deoB phosphopentomutase METABOLISM Carbohydrate 1.81 1.44 -0.35 -0.72 0.020 transport and metabolism EcolC_3674 b4382 deoA thymidine phosphorylase METABOLISM Nucleotide 1.16 0.58 -0.09 -0.67 0.012 transport and metabolism EcolC_3675 b4381 deoC 2-deoxyribose-5-phosphate aldolase, METABOLISM Nucleotide 1.52 0.65 -0.09 -0.96 0.018 NAD(P)-linked transport and metabolism EcolC_3676 b4380 yjjI conserved protein METABOLISM Nucleotide -0.83 0.11 -0.15 0.79 0.008 transport and metabolism EcolC_3678 b4378 yjjV predicted DNase INFORMATION Replication, 0.28 0.42 0.12 0.26 0.944 STORAGE AND recombination PROCESSING and repair EcolC_3679 b4377 yjjU predicted phospholipase, patatin-like POORLY General -0.45 -0.21 -0.15 0.09 0.092 family CHARACTERIZ function ED prediction EcolC_3680 b4568 ytjA predicted protein - -l -0.50 -0.52 0.20 0.17 0.416 EcolC_3681 b4376 osmY periplasmic protein POORLY General -0.88 -1.35 0.39 -0.08 0.666 CHARACTERIZ function ED prediction EcolC_3682 b4375 prfC peptide chain release factor RF-3 INFORMATION Translation,l 0.13 0.22 0.33 0.41 0.663 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3683 b4374 yjjG dUMP phosphatase POORLY General -0.02 0.00 0.19 0.21 0.732 CHARACTERIZ function ED prediction EcolC_3684 b4373 rimI ribosomal-protein-S18-alanine N- POORLY Generall -0.04 0.15 0.15 0.34 0.413 acetyltransferase CHARACTERIZ function ED prediction EcolC_3685 b4372 holD DNA polymerase III, psi subunit INFORMATION Replication,l -0.46 -0.06 -0.10 0.30 0.200 STORAGE AND recombination PROCESSING and repair EcolC_3686 b4371 rsmC 16S rRNA m(2)G1207 methyltransferase, INFORMATION Translation, 0.28 0.32 0.27 0.30 0.922 SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3687 b4567 yjjZ predicted protein - - 0.06 0.11 0.26 0.31 0.863 EcolC_3689 b4366 bglJ bgl operon transcriptional activator CELLULAR Signal -0.07 -0.08 -0.01 -0.03 0.856 PROCESSES transduction AND mechanisms SIGNALING EcolC_3690 b4365 yjjQ DNA-binding transcriptional regulator CELLULAR Signal -0.12 -0.06 -0.18 -0.11 0.671 PROCESSES transduction AND mechanisms SIGNALING EcolC_3691 b4364 yjjP inner membrane protein, H-NS-repressed, POORLY Function 0.16 0.00 0.37 0.21 0.398 DUF1212 family CHARACTERIZ unknown ED EcolC_3693 b4362 dnaT DNA biosynthesis protein (primosomal POORLY General -0.06 0.06 0.16 0.29 0.721 protein I) CHARACTERIZ function ED prediction EcolC_3694 b4361 dnaC DNA biosynthesis protein INFORMATION Replication,l 0.08 0.26 0.05 0.23 0.847 STORAGE AND recombination PROCESSING and repair EcolC_3695 b4360 yjjA conserved protein - - -0.19 0.48 0.03 0.70 0.076 EcolC_3696 b4359 opgB phosphoglycerol I and II CELLULAR Cell 0.37 0.29 0.07 -0.01 0.620 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3697 b4358 yjjN L-galactonate oxidoreductase METABOLISM Amino acid -0.06 -0.09 0.04 0.01 0.902 transport and metabolism EcolC_3698 b4357 yjjM DNA-binding transcriptional activator for INFORMATION Transcription 0.03 0.15 0.18 0.31 0.123 yjjMN; mutants fail to grow on L- STORAGE AND galactonate PROCESSING EcolC_3699 b4356 yjjL L-galactonate transporter METABOLISM Carbohydrate -0.02 -0.02 0.01 0.01 0.650 transport and metabolism EcolC_3700 b4355 tsr methyl-accepting chemotaxis protein I, CELLULAR Cell motility 0.46 0.23 0.28 0.05 0.197 serine sensor receptor PROCESSES AND SIGNALING EcolC_3703 - hpaE 5-carboxy-2-hydroxymuconate METABOLISM Energy 0.48 0.15 0.34 0.01 0.076 semialdehyde dehydrogenase production and conversion EcolC_3705 - hpaF 5-carboxymethyl-2-hydroxymuconate METABOLISM Amino acid 0.36 -0.03 0.23 -0.15 0.169 delta-isomerase transport and metabolism EcolC_3708 - hpaX 4-hydroxyphenylacetate permease METABOLISM Inorganic ion -0.51 -0.35 -0.32 -0.16 0.594 transport and metabolism EcolC_3709 - hpaA HpaA INFORMATION Transcription 0.34 0.29 0.35 0.30 0.913 STORAGE AND PROCESSING EcolC_3711 - hpaC 4-hydroxyphenylacetate 3-monooxygenase, POORLY General 0.09 0.03 0.07 0.00 0.169 reductase component CHARACTERIZ function ED prediction EcolC_3713 b4353 yjiX conserved protein POORLY Functionl -0.54 -0.68 -0.73 -0.88 0.326 CHARACTERIZ unknown ED EcolC_3723 b4340 yjiR fused predicted DNA-binding INFORMATION Transcription 0.09 -0.17 0.07 -0.19 0.429 transcriptional regulator/predicted STORAGE AND aminotransferase PROCESSING EcolC_3728 b4335 yjiM predicted 2-hydroxyglutaryl-CoA METABOLISM Amino acid 0.65 1.40 0.37 1.12 0.012 dehydratase transport and metabolism EcolC_3729 b4334 yjiL predicted ATPase, activator of (R)- METABOLISM Lipid 0.71 1.57 0.37 1.22 0.038 hydroxyglutaryl-CoA dehydratase transport and metabolism EcolC_3731 b4333 yjiK conserved protein POORLY Function 0.24 0.69 0.35 0.80 0.062 CHARACTERIZ unknown ED EcolC_3732 b4332 yjiJ predicted inner membrane protein - - 0.06 0.43 0.25 0.62 0.016 EcolC_3734 b4330 yjiH predicted inner membrane protein POORLY Function -1.24 -0.98 0.01 0.28 0.045 CHARACTERIZ unknown ED EcolC_3735 b4329 yjiG inner membrane protein, SpmB family POORLY Function -0.90 -0.46 0.03 0.47 0.003 CHARACTERIZ unknown ED EcolC_3736 b4328 iadA isoaspartyl dipeptidase METABOLISM Nucleotide -0.93 -0.40 -0.04 0.50 0.003 transport and metabolism EcolC_3737 b4327 yjiE hypochlorite-responsive transcription INFORMATION Transcription -0.32 -0.20 0.13 0.25 0.120 factor STORAGE AND PROCESSING EcolC_3738 b4326 iraD RpoS stabilzer after DNA damage, anti- POORLY Function -0.69 -0.74 -0.44 -0.49 0.876 RssB factor CHARACTERIZ unknown ED EcolC_3740 b4324 uxuR DNA-binding transcriptional repressor INFORMATION Transcription -0.07 0.06 0.00 0.13 0.389 STORAGE AND PROCESSING EcolC_3741 b4323 uxuB D-mannonate oxidoreductase, NAD- METABOLISM Carbohydrate 0.58 0.41 0.14 -0.03 0.099 dependent transport and metabolism EcolC_3742 b4322 uxuA mannonate hydrolase METABOLISM Carbohydrate 0.80 0.31 0.37 -0.12 0.066 transport and metabolism EcolC_3743 b4320 fimH minor component of type 1 fimbriae - - -0.03 0.05 0.28 0.36 0.819 EcolC_3748 b4269 yjgB predicted alcohol dehydrogenase, Zn- POORLY General 0.08 -0.82 -0.07 -0.97 0.094 dependent and NAD(P)-binding CHARACTERIZ function ED prediction EcolC_3750 b4262 lptG lipopolysaccharide export ABC permease POORLY Generall 0.39 0.43 0.43 0.47 0.664 of the LptBFGC export complex CHARACTERIZ function ED prediction EcolC_3751 b4261 lptF lipopolysaccharide export ABC permease POORLY Generall 0.51 0.29 0.22 0.00 0.687 of the LptBFGC export complex CHARACTERIZ function ED prediction EcolC_3753 b4259 holC DNA polymerase III, chi subunit INFORMATION Replication,l -0.48 -0.25 -0.13 0.10 0.233 STORAGE AND recombination PROCESSING and repair EcolC_3754 b4258 valS valyl-tRNA synthetase INFORMATION Translation, -0.49 -0.32 -0.16 0.01 0.181 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3755 b4257 yjgN inner membrane protein, DUF898 family POORLY Function -0.12 -0.08 -0.03 0.01 0.916 CHARACTERIZ unknown ED EcolC_3756 b4256 yjgM predicted acetyltransferase METABOLISM Amino acid 0.02 0.17 0.37 0.52 0.265 transport and metabolism EcolC_3757 b4255 rraB protein inhibitor of RNase E POORLY Function -0.30 0.14 0.12 0.55 0.027 CHARACTERIZ unknown ED EcolC_3758 b4254 argI ornithine carbamoyltransferase 1 METABOLISM Amino acid 0.02 -0.02 0.15 0.11 0.708 transport and metabolism EcolC_3761 b4252 tabA biofilm modulator regulated by toxins METABOLISM Carbohydrate -0.26 -0.02 -0.01 0.23 0.136 transport and metabolism EcolC_3762 b4251 bdcR transcriptional repressor for divergent INFORMATION Transcription 0.02 0.27 0.16 0.41 0.271 bdcA STORAGE AND PROCESSING EcolC_3763 b4249 bdcA c-di-GMP-binding biofilm dispersal METABOLISM Lipid 0.24 0.13 0.37 0.26 0.546 mediator protein transport and metabolism EcolC_3764 b4248 yjgH conserved protein, UPF0131 family INFORMATION Translation, -0.13 -0.03 0.15 0.24 0.992 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3765 b4246 pyrL pyrBI operon leader peptide - - 0.16 0.26 0.27 0.37 0.251 EcolC_3766 b4245 pyrB aspartate carbamoyltransferase, catalytic METABOLISM Nucleotide -0.33 -0.11 0.07 0.29 0.257 subunit transport and metabolism EcolC_3767 b4244 pyrI aspartate carbamoyltransferase, regulatory METABOLISM Nucleotide -0.08 -0.15 0.36 0.29 0.663 subunit transport and metabolism EcolC_3768 b4243 ridA conserved protein, UPF0131 family INFORMATION Translation, -1.00 -0.26 -0.31 0.44 0.010 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3769 b4242 mgtA magnesium transporter METABOLISM Inorganic ion 0.38 0.51 0.53 0.66 0.258 transport and metabolism EcolC_3770 b4241 treR DNA-binding transcriptional repressor INFORMATION Transcription 0.08 0.54 0.13 0.59 0.434 STORAGE AND PROCESSING EcolC_3771 b4240 treB fused trehalose(maltose)-specific PTS METABOLISM Carbohydrate 0.85 -0.05 0.06 -0.85 0.035 enzyme: IIB component/IIC component transport and metabolism EcolC_3772 b4239 treC trehalose-6-P hydrolase METABOLISM Carbohydrate 1.44 -0.04 -0.06 -1.54 0.000 transport and metabolism EcolC_3773 b4238 nrdD anaerobic ribonucleoside-triphosphate METABOLISM Nucleotide -0.39 -0.26 0.41 0.54 0.826 reductase transport and metabolism EcolC_3774 b4237 nrdG anaerobic ribonucleotide reductase CELLULAR Posttranslatio 0.12 0.25 0.45 0.59 0.431 activating protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3775 b4236 cybC - - - 0.00 -0.15 -0.02 -0.17 0.685 EcolC_3776 b4235 pmbA predicted peptidase required for the POORLY General -0.01 0.12 -0.01 0.12 0.816 maturation and secretion of the antibiotic CHARACTERIZ function peptide MccB17 ED prediction EcolC_3777 b4234 yjgA conserved protein, ribosome-associated POORLY Functionl -0.40 -0.26 0.33 0.47 0.373 CHARACTERIZ unknown ED EcolC_3778 b4233 mpl UDP-N-acetylmuramate:L-alanyl-gamma- CELLULAR Cell 0.39 0.29 -0.08 -0.18 0.810 D-glutamyl- meso-diaminopimelate ligase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3779 b4232 fbp fructose-1,6-bisphosphatase I METABOLISM Carbohydrate 0.19 0.34 0.08 0.23 0.145 transport and metabolism EcolC_3780 b4231 yjfF predicted sugar transporter subunit: METABOLISM Carbohydrate 0.08 0.26 0.14 0.31 0.665 membrane component of ABC superfamily transport and metabolism EcolC_3781 b4230 ytfT predicted sugar transporter subunit: METABOLISM Carbohydrate 0.08 -0.07 0.31 0.16 0.258 membrane component of ABC superfamily transport and metabolism EcolC_3782 b4485 ytfR predicted sugar transporter subunit: ATP- METABOLISM Carbohydrate 0.14 0.00 0.30 0.15 0.469 binding component of ABC superfamily transport and metabolism EcolC_3783 b4227 ytfQ galactofuranose binding proteint: METABOLISM Carbohydrate -0.43 -0.11 -0.23 0.09 0.264 periplasmic-binding component of ABC transport and superfamily metabolism EcolC_3784 b4226 ppa inorganic pyrophosphatase METABOLISM Energy -0.13 0.10 -0.08 0.16 0.414 production and conversion EcolC_3785 b4222 ytfP GGCT-like protein POORLY Function -0.34 -0.45 0.32 0.21 0.321 CHARACTERIZ unknown ED EcolC_3786 b4221 tamB translocation and assembly module for POORLY Function 0.02 -0.13 0.25 0.11 0.293 autotransporter export, inner membrane CHARACTERIZ unknown subunit ED EcolC_3787 b4220 tamA translocation and assembly module for CELLULAR Cell -0.03 0.02 0.26 0.31 0.995 autotransporter export, outer membrane PROCESSES wall/membran subunit AND e/envelope SIGNALING biogenesis EcolC_3788 b4219 msrA methionine sulfoxide reductase A CELLULAR Posttranslatio -0.84 -0.70 -0.14 0.00 0.126 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3789 b4218 ytfL inner membrane protein, UPF0053 family POORLY General -0.92 -0.78 -0.25 -0.10 0.912 CHARACTERIZ function ED prediction EcolC_3790 b4217 ytfK conserved protein, DUF1107 family - -l 1.37 0.94 0.16 -0.28 0.139 EcolC_3791 b4216 ytfJ predicted transcriptional regulator POORLY General 0.64 0.49 0.07 -0.07 0.625 CHARACTERIZ function ED prediction EcolC_3792 b4214 cysQ PAPS (adenosine 3'-phosphate 5'- METABOLISM Inorganicl ion -1.21 -1.56 0.20 -0.15 0.023 phosphosulfate) 3'(2'),5'-bisphosphate transport and nucleotidase metabolism EcolC_3793 b4213 cpdB 2':3'-cyclic-nucleotide 2'-phosphodiesterase METABOLISM Nucleotide -0.24 -0.09 -0.28 -0.13 0.221 transport and metabolism EcolC_3794 b4212 ytfH predicted transcriptional regulator, HxlR- INFORMATION Transcription 0.58 0.33 0.45 0.21 0.597 type, DUF24 family STORAGE AND PROCESSING EcolC_3795 b4211 qorB NAD(P)H:quinone oxidoreductase CELLULAR Cell 0.30 0.40 0.29 0.38 0.441 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3797 b4209 ytfE iron-sulfur cluster repair protein RIC CELLULAR Cell cycle 0.30 0.22 0.21 0.13 0.826 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_3798 b4208 cycA D-alanine/D-serine/glycine transporter METABOLISM Amino acid 1.00 0.18 0.16 -0.66 0.055 transport and metabolism EcolC_3799 b4207 fklB FKBP-type peptidyl-prolyl cis-trans CELLULAR Posttranslatio 0.21 0.06 0.11 -0.04 0.963 isomerase (rotamase) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3800 b4206 ytfB OapA family protein, function unknown CELLULAR Cell -0.11 -0.32 0.19 -0.02 0.066 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3801 b4205 ytfA - - - 0.42 0.53 0.38 0.48 0.366 EcolC_3804 - - hypothetical protein METABOLISM Lipid -0.18 -0.06 -0.10 0.02 0.425 transport and metabolism EcolC_3810 b4203 rplI 50S ribosomal subunit protein L9 INFORMATION Translation, -2.18 -1.29 -0.09 0.80 0.015 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3811 b4202 rpsR 30S ribosomal subunit protein S18 INFORMATION Translation, -2.04 -1.29 -0.10 0.65 0.007 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3812 b4201 priB primosomal protein N INFORMATION Replication, -2.36 -1.15 -0.22 0.99 0.001 STORAGE AND recombination PROCESSING and repair EcolC_3813 b4200 rpsF 30S ribosomal subunit protein S6 INFORMATION Translation, -2.30 -1.23 -0.12 0.96 0.011 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3814 b4199 yjfY predicted protein - - -0.03 -0.03 0.16 0.16 0.808 EcolC_3816 b4197 ulaE L-xylulose 5-phosphate 3-epimerase METABOLISM Carbohydrate 0.40 0.40 0.36 0.35 0.893 transport and metabolism EcolC_3817 b4196 ulaD 3-keto-L-gulonate 6-phosphate METABOLISM Carbohydrate 0.41 0.70 0.21 0.51 0.032 decarboxylase transport and metabolism EcolC_3818 b4195 ulaC L-ascorbate-specific enzyme IIA METABOLISM Carbohydrate 0.07 0.22 0.25 0.41 0.143 component of PTS transport and metabolism EcolC_3819 b4194 ulaB L-ascorbate-specific enzyme IIB METABOLISM Carbohydrate 0.49 0.53 0.29 0.33 0.729 component of PTS transport and metabolism EcolC_3820 b4193 ulaA L-ascorbate-specific enzyme IIC POORLY Function 0.15 0.03 0.04 -0.07 0.578 component of PTS CHARACTERIZ unknown ED EcolC_3821 b4192 ulaG L-ascorbate 6-phosphate lactonase POORLY General 0.17 0.18 0.15 0.15 0.947 CHARACTERIZ function ED prediction l EcolC_3822 b4191 ulaR transcriptional tepressor for the L- INFORMATION Transcription 0.52 0.30 0.16 -0.06 0.506 ascorbate utilization (ula) divergon STORAGE AND PROCESSING EcolC_3823 b4190 yjfP acyl CoA esterase POORLY General 0.42 0.45 0.39 0.41 0.690 CHARACTERIZ function ED prediction EcolC_3825 b4188 yjfN predicted protein - -l 0.66 0.07 0.43 -0.16 0.016 EcolC_3826 b4187 aidB DNA alkylation damage repair protein; METABOLISM Lipid -0.21 -0.28 0.45 0.38 0.169 flavin-containing DNA binding protein, transport and weak isovaleryl CoA dehydrogenase metabolism EcolC_3827 b4186 yjfC ATP-Grasp family ATPase METABOLISM Amino acid -0.42 -0.74 -0.49 -0.80 0.099 transport and metabolism EcolC_3828 b4185 yjfM conserved protein, DUF1190 family POORLY Function 0.01 -0.20 -0.03 -0.24 0.180 CHARACTERIZ unknown ED EcolC_3829 b4184 yjfL inner membrane protein, UPF0719 family POORLY Function -0.19 -0.23 -0.10 -0.15 0.461 CHARACTERIZ unknown ED EcolC_3830 b4183 yjfK conserved protein, DUF2491 family - - 0.02 -0.11 -0.12 -0.25 0.309 EcolC_3831 b4182 yjfJ conserved protein, PspA/IM30 family INFORMATION Transcription 0.11 0.19 0.14 0.22 0.721 STORAGE AND PROCESSING EcolC_3832 b4181 yjfI conserved protein, DUF2170 family POORLY Function 0.13 0.02 -0.06 -0.16 0.266 CHARACTERIZ unknown ED EcolC_3833 b4180 rlmB 23S rRNA mG2251 2'-O-ribose INFORMATION Translation, 0.21 0.45 0.04 0.27 0.667 methyltransferase, SAM-dependent STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3834 b4179 rnr R, RNase R INFORMATION Transcription 0.63 0.24 0.19 -0.20 0.123 STORAGE AND PROCESSING EcolC_3835 b4178 nsrR nitric oxide-sensitive repressor for NO INFORMATION Transcription -0.05 0.01 0.33 0.39 0.860 regulon STORAGE AND PROCESSING EcolC_3836 b4177 purA adenylosuccinate synthetase METABOLISM Nucleotide 0.07 0.76 0.07 0.76 0.036 transport and metabolism EcolC_3837 b4176 yjeT conserved protein, DUF2065 family POORLY Function 0.21 0.50 0.08 0.37 0.055 CHARACTERIZ unknown ED EcolC_3838 b4175 hflC modulator for HflB protease specific for CELLULAR Posttranslatio 0.39 -0.26 -0.44 -1.10 0.015 phage lambda cII repressor PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3839 b4174 hflK modulator for HflB protease specific for CELLULAR Posttranslatio 0.47 0.09 -0.34 -0.72 0.021 phage lambda cII repressor PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3840 b4173 hflX GTPase, stimulated by 50S subunit binding POORLY General 0.04 -0.29 0.12 -0.22 0.131 CHARACTERIZ function ED prediction EcolC_3841 b4172 hfq global sRNA chaperone; HF-I, host factor POORLY Generall 0.36 0.04 0.18 -0.14 0.106 for RNA phage Q beta replication CHARACTERIZ function ED prediction l EcolC_3842 b4171 miaA delta(2)-isopentenylpyrophosphate tRNA- INFORMATION Translation, -0.21 -0.36 0.32 0.17 0.618 adenosine transferase STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3843 b4170 mutL methyl-directed mismatch repair protein INFORMATION Replication, 0.64 0.07 0.15 -0.42 0.091 STORAGE AND recombination PROCESSING and repair EcolC_3844 b4169 amiB N-acetylmuramoyl-l-alanine amidase II CELLULAR Cell 0.14 0.07 0.37 0.30 0.150 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3845 b4168 tsaE tRNA(ANN) t(6)A37 POORLY General 0.06 0.16 0.15 0.25 0.953 threonylcarbamoyladenosine modification CHARACTERIZ function protein; ADP binding protein ED prediction EcolC_3846 b4167 nnr bifunctional NAD(P)H-hydrate repair METABOLISM Carbohydratel 0.18 -0.01 0.20 0.01 0.413 enzyme; C-terminal domain ADP- transport and dependent (S)-NAD(P)H-hydrate metabolism dehydratase and N-terminal domain NAD(P)H-hydrate epimerase EcolC_3847 b4166 queG epoxyqueuosine reductase, cobalamine- METABOLISM Energy 0.96 1.04 0.20 0.28 0.251 stimulated; queosine biosynthesis production and conversion EcolC_3848 b4162 orn oligoribonuclease INFORMATION RNA 0.51 0.86 0.36 0.71 0.430 STORAGE AND processing PROCESSING and modification EcolC_3849 b4161 rsgA ribosome small subunit-dependent GTPase POORLY General 0.36 0.48 0.10 0.22 0.843 A CHARACTERIZ function ED prediction l EcolC_3850 b4160 psd phosphatidylserine decarboxylase METABOLISM Lipid 0.28 0.20 0.05 -0.03 0.369 transport and metabolism EcolC_3851 b4159 mscM mechanosensitive channel protein, CELLULAR Cell 0.18 0.24 0.32 0.38 0.843 miniconductance PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3852 b4158 yjeO inner membrane protein - - -0.02 0.01 -0.02 0.01 0.890 EcolC_3853 b4157 yjeN predicted protein - - 0.31 0.39 0.14 0.23 0.621 EcolC_3854 b4156 yjeM predicted transporter METABOLISM Amino acid 0.71 0.40 0.07 -0.24 0.026 transport and metabolism EcolC_3855 b4155 epmA Elongation Factor P Lys34 lysyltransferase INFORMATION Translation, 0.02 0.08 0.40 0.46 0.887 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3856 b4154 frdA fumarate reductase (anaerobic) catalytic METABOLISM Energy -0.36 0.43 -0.77 0.02 0.001 and NAD/flavoprotein subunit production and conversion EcolC_3857 b4153 frdB fumarate reductase (anaerobic), Fe-S METABOLISM Energy 0.23 0.80 -0.68 -0.11 0.186 subunit production and conversion EcolC_3858 b4152 frdC fumarate reductase (anaerobic), membrane METABOLISM Energy -0.29 0.41 -0.76 -0.07 0.007 anchor subunit production and conversion EcolC_3859 b4151 frdD fumarate reductase (anaerobic), membrane METABOLISM Energy -0.44 0.42 -0.62 0.24 0.002 anchor subunit production and conversion EcolC_3860 b4150 ampC beta-lactamase/D-alanine carboxypeptidase CELLULAR Defense -0.02 0.39 -0.17 0.24 0.600 PROCESSES mechanisms AND SIGNALING EcolC_3861 b4149 blc outer membrane lipoprotein (lipocalin), CELLULAR Cell -1.64 -1.98 0.52 0.19 0.123 cell division and growth function PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3862 b4148 sugE multidrug efflux system protein METABOLISM Inorganic ion -0.58 -1.17 0.58 -0.02 0.225 transport and metabolism EcolC_3863 b4411 ecnB entericidin B membrane lipoprotein POORLY Function -0.40 -0.71 0.08 -0.22 0.103 CHARACTERIZ unknown ED EcolC_3864 b4410 ecnA entericidin A membrane lipoprotein, POORLY Function 0.28 0.53 0.65 0.90 0.252 antidote entericidin B CHARACTERIZ unknown ED EcolC_3865 b4147 efp polyproline-specific translation elongation INFORMATION Translation, -0.32 -0.09 0.12 0.36 0.387 factor EF-P STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3866 b4146 epmB EF-P-Lys34 lysylation protein; weak lysine METABOLISM Amino acid 0.33 0.22 0.52 0.41 0.940 2,3-aminomutase transport and metabolism EcolC_3867 b4145 yjeJ predicted protein - - -0.10 -0.11 -0.03 -0.03 0.817 EcolC_3868 b4144 yjeI conserved protein - - -0.22 -0.02 -0.14 0.06 0.947 EcolC_3869 b4143 groL Cpn60 chaperonin GroEL, large subunit CELLULAR Posttranslati 2.69 2.03 -0.30 -0.96 0.031 of GroESL PROCESSES onal AND modification, SIGNALING protein turnover, chaperones EcolC_3870 b4142 groS Cpn10 chaperonin GroES, small subunit of CELLULAR Posttranslatio 2.63 1.99 -0.50 -1.14 0.003 GroESL PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3871 b4141 yjeH predicted transporter METABOLISM Amino acid 0.59 0.46 0.12 0.00 0.821 transport and metabolism EcolC_3872 b4140 fxsA suppressor of F exclusion of phage T7 POORLY General -0.63 -0.37 -0.54 -0.28 0.207 CHARACTERIZ function ED prediction EcolC_3873 b4139 aspA aspartate ammonia-lyase METABOLISM Aminol acid 0.51 0.01 0.14 -0.36 0.036 transport and metabolism EcolC_3874 b4138 dcuA C4-dicarboxylate antiporter POORLY General -0.66 -1.18 0.27 -0.24 0.004 CHARACTERIZ function ED prediction EcolC_3875 b4137 cutA divalent-cation tolerance protein, copper METABOLISM Inorganicl ion -0.10 -0.01 0.13 0.22 0.753 sensitivity transport and metabolism EcolC_3876 b4136 dsbD fused thiol:disulfide interchange protein: CELLULAR Posttranslatio 0.19 0.36 0.26 0.43 0.312 activator of DsbC/conserved protein PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3877 b4135 yjdC predicted transcriptional regulator INFORMATION Transcription -0.66 -0.52 0.02 0.16 0.836 STORAGE AND PROCESSING EcolC_3892 b1370 insH1 - - - 1.13 1.09 0.34 0.30 0.738 EcolC_3893 b0022 insA IS1 repressor TnpA INFORMATION Replication, 0.18 0.36 0.53 0.71 0.123 STORAGE AND recombination PROCESSING and repair EcolC_3893 b4576 insB1 - - - -0.02 0.01 0.32 0.35 0.783 EcolC_3894 b4133 cadC DNA-binding transcriptional activator INFORMATION Transcription 0.22 0.60 0.39 0.77 0.032 STORAGE AND PROCESSING EcolC_3895 b4132 cadB predicted lysine/cadaverine transporter METABOLISM Amino acid -0.42 -0.37 -0.40 -0.35 0.850 transport and metabolism EcolC_3896 b4131 cadA lysine decarboxylase, acid-inducible METABOLISM Amino acid -0.14 -0.19 -0.03 -0.07 0.240 transport and metabolism EcolC_3897 b4130 dtpC dipeptide and tripeptide permease METABOLISM Amino acid 0.04 0.14 0.11 0.20 0.421 transport and metabolism EcolC_3898 b4129 lysU lysine tRNA synthetase, inducible INFORMATION Translation, -0.45 0.06 -0.20 0.31 0.108 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3899 b4559 yjdO predicted protein - - -0.26 -0.32 0.21 0.15 0.812 EcolC_3900 b4127 yjdJ predicted acyltransferase with acyl-CoA N- POORLY General -1.70 -1.88 0.46 0.28 0.442 acyltransferase domain CHARACTERIZ function ED prediction EcolC_3901 b4126 yjdI conserved protein POORLY Functionl -1.98 -1.56 0.40 0.83 0.218 CHARACTERIZ unknown ED EcolC_3903 b4124 dcuR DNA-binding response regulator in two- INFORMATION Transcription 0.12 0.38 0.01 0.27 0.338 component regulatory system with DcuS STORAGE AND PROCESSING EcolC_3904 b4123 dcuB C4-dicarboxylate transporter, anaerobic; POORLY General -1.67 1.44 -1.99 1.12 0.001 DcuS co-sensor CHARACTERIZ function ED prediction EcolC_3905 b4122 fumB anaerobic class I fumarate hydratase METABOLISM Energyl -1.18 0.04 -1.56 -0.34 0.006 (fumarase B) production and conversion EcolC_3906 b4121 yjdF conserved inner membrane protein POORLY Function -0.10 0.33 0.40 0.83 0.784 CHARACTERIZ unknown ED EcolC_3907 b4120 melB melibiose:sodium symporter METABOLISM Carbohydrate -1.00 -0.43 0.01 0.58 0.037 transport and metabolism EcolC_3908 b4119 melA alpha-galactosidase, NAD(P)-binding METABOLISM Carbohydrate -0.55 0.52 -0.09 0.98 0.001 transport and metabolism EcolC_3909 b4118 melR DNA-binding transcriptional dual regulator INFORMATION Transcription 0.30 0.52 0.38 0.60 0.510 STORAGE AND PROCESSING EcolC_3910 b4117 adiA arginine decarboxylase METABOLISM Amino acid -0.43 -0.46 -0.54 -0.57 0.827 transport and metabolism EcolC_3911 b4116 adiY DNA-binding transcriptional activator INFORMATION Transcription -0.08 0.03 0.32 0.44 0.479 STORAGE AND PROCESSING EcolC_3912 b4115 adiC arginine:agmatine antiporter METABOLISM Amino acid -0.05 -0.12 0.10 0.02 0.928 transport and metabolism EcolC_3913 b4114 eptA lipid A phosphoethanolamine transferase POORLY General -0.13 -0.13 0.21 0.21 0.970 CHARACTERIZ function ED prediction l EcolC_3914 b4113 basR DNA-binding response regulator in two- CELLULAR Signal 0.12 -0.11 0.20 -0.03 0.521 component regulatory system with BasS PROCESSES transduction AND mechanisms SIGNALING EcolC_3915 b4112 basS sensory histidine kinase in two-component CELLULAR Signal 0.07 0.31 0.31 0.54 0.421 regulatory system with BasR PROCESSES transduction AND mechanisms SIGNALING EcolC_3916 b4111 proP proline/glycine betaine transporter METABOLISM Carbohydrate -0.16 -0.33 0.46 0.29 0.637 transport and metabolism EcolC_3917 b4110 yjcZ mutational suppressor of yhjH motility - - 0.24 0.29 0.35 0.40 0.719 mutation, function unknown EcolC_3919 b4108 yjdM conserved protein METABOLISM Inorganic ion 0.07 -0.04 0.22 0.11 0.540 transport and metabolism EcolC_3920 b4107 yjdN conserved protein POORLY Function 0.12 0.05 0.30 0.22 0.918 CHARACTERIZ unknown ED EcolC_3921 b4106 phnC phosphonate ABC transporter ATP-binding METABOLISM Inorganic ion 0.10 -0.20 0.02 -0.28 0.168 subunit transport and metabolism EcolC_3922 b4105 phnD phosphonate ABC transporter periplasmic METABOLISM Inorganic ion -0.22 -0.07 -0.16 -0.01 0.963 binding protein transport and metabolism EcolC_3924 b4102 phnF predicted DNA-binding transcriptional INFORMATION Transcription 0.14 0.13 0.12 0.11 0.894 regulator of phosphonate uptake and STORAGE AND biodegradation PROCESSING EcolC_3925 b4101 phnG ribophosphonate triphosphate synthase METABOLISM Inorganic ion -0.05 -0.04 0.14 0.15 0.800 subunit transport and metabolism EcolC_3926 b4100 phnH ribophosphonate triphosphate synthase METABOLISM Inorganic ion 0.00 0.02 0.18 0.19 0.918 subunit transport and metabolism EcolC_3928 b4098 phnJ carbon-phosphorus lyase, SAM-dependent METABOLISM Inorganic ion 0.08 0.06 0.20 0.17 0.989 transport and metabolism EcolC_3929 b4097 phnK carbon-phosphorus lyase complex subunit, METABOLISM Inorganic ion -0.19 -0.02 0.07 0.24 0.099 putative ATP transporter ATP-binding transport and protein metabolism EcolC_3930 b4096 phnL ribophosphonate triphosphate synthase METABOLISM Inorganic ion 0.70 0.49 0.43 0.21 0.903 subunit; predicted ATP transporter ATP- transport and binding protein metabolism EcolC_3931 b4095 phnM ribophosphonate triphosphate hydrolase METABOLISM Inorganic ion 0.15 0.05 0.34 0.24 0.666 transport and metabolism EcolC_3933 b4093 phnO aminoalkylphosphonate N- METABOLISM Amino acid -0.09 -0.04 0.33 0.38 0.685 acetyltransferase transport and metabolism EcolC_3935 b4487 yjdP conserved protein - - 0.52 0.23 0.38 0.09 0.111 EcolC_3936 b4090 rpiB ribose 5-phosphate isomerase B/allose 6- METABOLISM Carbohydrate 0.06 0.13 0.10 0.17 0.716 phosphate isomerase transport and metabolism EcolC_3937 b4089 rpiR DNA-binding transcriptional repressor INFORMATION Transcription -0.08 0.04 0.01 0.13 0.284 STORAGE AND PROCESSING EcolC_3938 b4088 alsB D-allose transporter subunit METABOLISM Carbohydrate 0.27 -0.07 0.19 -0.15 0.162 transport and metabolism EcolC_3939 b4087 alsA fused D-allose transporter subunits of ABC METABOLISM Carbohydrate 0.16 -0.11 -0.13 -0.40 0.011 superfamily: ATP-binding components transport and metabolism EcolC_3940 b4086 alsC D-allose transporter subunit METABOLISM Carbohydrate 0.26 0.31 0.33 0.38 0.629 transport and metabolism EcolC_3941 b4085 alsE allulose-6-phosphate 3-epimerase METABOLISM Carbohydrate 0.02 -0.01 0.20 0.17 0.433 transport and metabolism EcolC_3942 b4084 alsK D-allose kinase INFORMATION Transcription -0.04 -0.13 -0.05 -0.15 0.751 STORAGE AND PROCESSING EcolC_3943 b4083 yjcS conserved protein, metallo-beta-lactamase METABOLISM Secondary -0.02 -0.04 -0.09 -0.12 0.881 superfamily metabolites biosynthesis, transport and catabolism EcolC_3945 b4082 mdtN membrane fusion protein of efflux pump CELLULAR Defense -0.02 -0.09 -0.10 -0.18 0.540 PROCESSES mechanisms AND SIGNALING EcolC_3946 b4081 mdtO membrane translocase (MDR) of MdtNOP POORLY Function -0.21 -0.02 0.04 0.24 0.354 efflux pump, PET family CHARACTERIZ unknown ED EcolC_3947 b4080 mdtP outer membrane factor of efflux pump CELLULAR Cell -0.18 0.03 -0.05 0.16 0.337 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3948 b4079 fdhF formate dehydrogenase-H, POORLY General -0.58 0.08 0.09 0.75 0.026 selenopolypeptide subunit CHARACTERIZ function ED prediction EcolC_3949 b4078 yjcO conserved protein POORLY Generall 0.27 0.13 0.42 0.27 0.075 CHARACTERIZ function ED prediction l EcolC_3951 b4076 nrfG heme lyase (NrfEFG) for insertion of heme CELLULAR Posttranslatio -0.12 0.02 0.05 0.20 0.090 into c552, subunit NrfG PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3952 b4075 nrfF heme lyase (NrfEFG) for insertion of heme CELLULAR Posttranslatio 0.09 0.23 0.37 0.51 0.415 into c552, subunit NrfF PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3953 b4074 nrfE heme lyase (NrfEFG) for insertion of heme CELLULAR Posttranslatio -0.05 0.07 0.00 0.13 0.847 into c552, subunit NrfE PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_3954 b4073 nrfD formate-dependent nitrite reductase, METABOLISM Inorganic ion -0.02 0.35 0.06 0.43 0.066 membrane subunit transport and metabolism EcolC_3956 b4071 nrfB nitrite reductase, formate-dependent, penta- METABOLISM Inorganic ion -0.05 0.02 0.09 0.17 0.519 heme cytochrome c transport and metabolism EcolC_3957 b4070 nrfA nitrite reductase, formate-dependent, METABOLISM Inorganic ion -0.36 0.01 0.07 0.45 0.059 cytochrome transport and metabolism EcolC_3958 b4069 acs acetyl-CoA synthetase METABOLISM Lipid 2.31 0.29 0.22 -1.79 0.003 transport and metabolism EcolC_3959 b4068 yjcH inner membrane protein, DUF485 family POORLY Function 0.35 -0.27 0.21 -0.40 0.071 CHARACTERIZ unknown ED EcolC_3960 b4067 actP acetate transporter POORLY General 0.38 0.27 0.25 0.14 0.134 CHARACTERIZ function ED prediction EcolC_3962 b4065 yjcE predicted cation/proton antiporter METABOLISM Inorganicl ion 0.03 0.03 0.35 0.35 0.850 transport and metabolism EcolC_3963 b4064 yjcD predicted permease POORLY General -0.20 -0.22 0.00 -0.03 0.974 CHARACTERIZ function ED prediction EcolC_3964 b4063 soxR DNA-binding transcriptional dual INFORMATION Transcriptionl 0.59 0.25 0.44 0.10 0.220 regulator, Fe-S center for redox-sensing STORAGE AND PROCESSING EcolC_3965 b4062 soxS DNA-binding transcriptional dual regulator INFORMATION Transcription 2.03 0.74 0.31 -0.98 0.010 STORAGE AND PROCESSING EcolC_3966 b4061 yjcC predicted membrane-anchored cyclic-di- CELLULAR Signal -0.06 -0.12 0.00 -0.05 0.931 GMP phosphodiesterase PROCESSES transduction AND mechanisms SIGNALING EcolC_3967 b4060 yjcB conserved protein - - -0.11 -0.07 0.19 0.22 0.398 EcolC_3968 b4059 ssb single-stranded DNA-binding protein INFORMATION Replication, 0.47 0.63 0.02 0.18 0.071 STORAGE AND recombination PROCESSING and repair EcolC_3969 b4058 uvrA ATPase and DNA damage recognition INFORMATION Replication, 0.91 0.51 0.36 -0.04 0.328 protein of nucleotide excision repair STORAGE AND recombination excinuclease UvrABC PROCESSING and repair EcolC_3970 b4057 yjbR conserved protein POORLY Function 0.32 0.75 0.41 0.84 0.980 CHARACTERIZ unknown ED EcolC_3971 b4056 yjbQ thiamin phosphate synthase POORLY Function -0.23 -0.32 0.11 0.02 0.947 CHARACTERIZ unknown ED EcolC_3972 b4055 aphA /phosphotransferase, class POORLY General -0.07 0.16 0.33 0.57 0.111 B, non-specific CHARACTERIZ function ED prediction EcolC_3974 b4054 tyrB tyrosine aminotransferase, tyrosine- METABOLISM Aminol acid -0.28 -0.22 0.16 0.23 0.891 repressible, PLP-dependent transport and metabolism EcolC_3975 b4053 alr alanine racemase 1, PLP-binding, CELLULAR Cell 0.19 0.08 0.07 -0.05 0.115 biosynthetic PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3976 b4052 dnaB replicative DNA helicase INFORMATION Replication, 0.25 0.18 0.27 0.20 0.897 STORAGE AND recombination PROCESSING and repair EcolC_3977 b4051 qorA quinone oxidoreductase, NADPH- METABOLISM Energy -1.25 -1.15 0.40 0.49 0.736 dependent production and conversion EcolC_3978 b4050 pspG phage shock protein G - - 0.67 -0.06 0.37 -0.37 0.114 EcolC_3979 b4049 dusA tRNA-dihydrouridine synthase A INFORMATION Translation, 0.38 0.43 0.23 0.28 0.708 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_3981 b4047 yjbL predicted protein - - -0.13 -0.07 -0.12 -0.07 0.604 EcolC_3983 b4045 yjbJ stress-induced protein, UPF0337 family POORLY Function -0.18 -0.21 0.48 0.45 0.829 CHARACTERIZ unknown ED EcolC_3984 b4044 dinF oxidative stress resistance protein; CELLULAR Defense 0.01 -0.02 -0.11 -0.14 0.995 predicted MATE family efflux pump; UV PROCESSES mechanisms and mitomycin C inducible protein AND SIGNALING EcolC_3985 b4043 lexA DNA-binding transcriptional repressor of INFORMATION Transcription 0.06 -0.18 0.28 0.04 0.601 SOS regulon STORAGE AND PROCESSING EcolC_3986 b4042 dgkA CELLULAR Cell 0.13 0.12 0.28 0.27 0.764 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_3987 b4041 plsB glycerol-3-phosphate O-acyltransferase METABOLISM Lipid 0.87 0.54 0.53 0.20 0.145 transport and metabolism EcolC_3988 b4040 ubiA p-hydroxybenzoate octaprenyltransferase METABOLISM Coenzyme 1.04 0.29 0.26 -0.49 0.011 transport and metabolism EcolC_3989 b4039 ubiC chorismate--pyruvate lyase METABOLISM Coenzyme 2.27 -0.17 0.18 -2.27 0.011 transport and metabolism EcolC_3992 b4037 malM maltose regulon periplasmic protein - - -2.98 -1.18 -1.23 0.57 0.003 EcolC_3993 b4036 lamB maltose outer membrane porin (maltoporin) METABOLISM Carbohydrate -3.07 -1.05 -1.72 0.30 0.001 transport and metabolism EcolC_3994 b4035 malK fused maltose transport subunit, ATP- METABOLISM Carbohydrate -3.01 -1.02 -1.27 0.72 0.002 binding component of ABC transport and superfamily/regulatory protein metabolism EcolC_3995 b4034 malE maltose transporter subunit METABOLISM Carbohydrate -1.50 0.91 -1.29 1.11 0.000 transport and metabolism EcolC_3996 b4033 malF maltose transporter subunit METABOLISM Carbohydrate -1.64 0.62 -1.08 1.18 0.002 transport and metabolism EcolC_3997 b4032 malG maltose transporter subunit METABOLISM Carbohydrate -1.07 0.61 -0.74 0.94 0.003 transport and metabolism EcolC_3998 b4031 xylE D-xylose transporter - - 0.05 0.41 -0.15 0.22 0.019 EcolC_3999 b4030 psiE phosphate starvation inducible protein POORLY Function -0.12 -0.04 0.13 0.21 0.743 CHARACTERIZ unknown ED EcolC_4001 b4029 yjbH predicted porin - - 0.00 -0.02 0.09 0.07 0.778 EcolC_4002 b4028 yjbG conserved protein - - 0.01 0.13 0.08 0.20 0.430 EcolC_4003 b4027 yjbF predicted lipoprotein - - 0.02 0.05 0.19 0.22 0.736 EcolC_4004 b4026 yjbE predicted protein - - 0.01 0.06 0.00 0.05 0.646 EcolC_4005 b4025 pgi glucosephosphate isomerase METABOLISM Carbohydrate -0.13 -0.45 -0.06 -0.38 0.023 transport and metabolism EcolC_4006 b4024 lysC aspartokinase III METABOLISM Amino acid -0.19 -0.13 -0.07 -0.01 0.995 transport and metabolism EcolC_4007 b4023 yjbD conserved protein - - 0.12 0.24 0.37 0.49 0.995 EcolC_4009 b4021 pepE (alpha)-aspartyl dipeptidase METABOLISM Amino acid -0.46 -0.19 -0.56 -0.28 0.615 transport and metabolism EcolC_4010 b4020 yjbB predicted Na+/Pi-cotransporter METABOLISM Inorganic ion 0.44 0.34 0.31 0.22 0.928 transport and metabolism EcolC_4011 b4019 metH homocysteine-N5-methyltetrahydrofolate METABOLISM Amino acid 0.44 0.35 -0.24 -0.32 0.955 transmethylase, B12-dependent transport and metabolism EcolC_4013 b4017 arpA ankyrin repeat protein - - -0.01 -0.25 -0.01 -0.25 0.167 EcolC_4014 b4016 aceK isocitrate dehydrogenase CELLULAR Signal -0.02 -0.05 0.05 0.02 0.584 kinase/phosphatase PROCESSES transduction AND mechanisms SIGNALING EcolC_4015 b4015 aceA isocitrate lyase METABOLISM Energy 0.45 0.18 0.40 0.14 0.027 production and conversion EcolC_4016 b4014 aceB malate synthase A METABOLISM Energy 0.27 0.14 0.29 0.15 0.160 production and conversion EcolC_4017 b4013 metA homoserine O-transsuccinylase METABOLISM Amino acid 0.00 -0.01 0.13 0.11 0.974 transport and metabolism EcolC_4019 b4006 purH fused IMP METABOLISM Nucleotide 0.00 -0.02 0.18 0.16 0.937 cyclohydrolase/phosphoribosylaminoimida transport and zolecarboxamide formyltransferase metabolism EcolC_4020 b4005 purD phosphoribosylglycinamide synthetase METABOLISM Nucleotide 0.05 0.06 0.28 0.29 0.975 phosphoribosylamine-glycine ligase transport and metabolism EcolC_4021 b4004 zraR fused DNA-binding response regulator in CELLULAR Signal 0.36 0.23 0.26 0.12 0.475 two-component regulatory system with PROCESSES transduction ZraS: response regulator/sigma54 AND mechanisms interaction protein SIGNALING EcolC_4022 b4003 zraS sensory histidine kinase in two-component CELLULAR Signal 0.42 0.52 0.16 0.26 0.393 regulatory system with ZraR PROCESSES transduction AND mechanisms SIGNALING EcolC_4023 b4002 zraP Zn-dependent periplasmic chaperone CELLULAR Intracellular 1.54 4.08 0.14 2.68 0.049 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4024 b4001 yjaH conserved protein - - 0.71 2.09 0.22 1.59 0.082 EcolC_4025 b4000 hupA HU, DNA-binding transcriptional INFORMATION Replication, -1.94 -1.46 -0.53 -0.05 0.568 regulator, alpha subunit STORAGE AND recombination PROCESSING and repair EcolC_4026 b3999 yjaG conserved protein POORLY Function 0.15 0.18 0.26 0.29 0.821 CHARACTERIZ unknown ED EcolC_4027 b3998 nfi endonuclease V; deoxyinosine 3' INFORMATION Replication, -0.19 -0.15 -0.11 -0.08 0.893 endonuclease STORAGE AND recombination PROCESSING and repair EcolC_4028 b3997 hemE uroporphyrinogen decarboxylase METABOLISM Coenzyme 0.08 0.04 -0.04 -0.07 0.959 transport and metabolism EcolC_4029 b3996 nudC NADH pyrophosphatase INFORMATION Replication, -0.30 -0.24 0.14 0.19 0.843 STORAGE AND recombination PROCESSING and repair EcolC_4030 b3995 rsd stationary phase protein, binds sigma 70 INFORMATION Transcription 0.24 0.01 0.08 -0.14 0.355 RNA polymerase subunit STORAGE AND PROCESSING EcolC_4031 b3994 thiC phosphomethylpyrimidine synthase METABOLISM Coenzyme 0.07 -0.01 0.17 0.09 0.532 transport and metabolism EcolC_4032 b3993 thiE thiamin phosphate synthase (thiamin METABOLISM Coenzyme 0.24 0.43 0.17 0.36 0.589 phosphate pyrophosphorylase) transport and metabolism EcolC_4033 b3992 thiF adenylyltransferase, modifies ThiS C- METABOLISM Coenzyme 0.11 0.01 0.14 0.04 0.619 terminus transport and metabolism EcolC_4034 b4407 thiS immediate sulfur donor in thiazole METABOLISM Coenzyme 0.20 0.37 0.28 0.45 0.767 formation transport and metabolism EcolC_4035 b3991 thiG thiamin biosynthesis ThiGH complex METABOLISM Coenzyme 0.20 0.14 0.20 0.13 0.641 subunit transport and metabolism EcolC_4036 b3990 thiH tyrosine lyase, involved in thiamin-thiazole METABOLISM Coenzyme -0.10 -0.17 -0.04 -0.11 0.939 moiety synthesis transport and metabolism EcolC_4037 b3988 rpoC RNA polymerase, beta prime subunit INFORMATION Transcription -0.64 -0.36 0.03 0.31 0.090 STORAGE AND PROCESSING EcolC_4038 b3987 rpoB RNA polymerase, beta subunit INFORMATION Transcription -1.45 -1.00 -0.16 0.28 0.670 STORAGE AND PROCESSING EcolC_4039 b3986 rplL 50S ribosomal subunit protein L7/L12 INFORMATION Translation, -1.61 -1.45 -0.14 0.02 0.475 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4040 b3985 rplJ 50S ribosomal subunit protein L10 INFORMATION Translation, -2.79 -2.74 -0.06 -0.01 0.597 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4041 b3984 rplA 50S ribosomal subunit protein L1 INFORMATION Translation, -2.25 -1.58 -0.15 0.52 0.006 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4042 b3983 rplK 50S ribosomal subunit protein L11 INFORMATION Translation, -2.90 -2.13 -0.13 0.65 0.026 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4043 b3982 nusG transcription termination factor INFORMATION Transcription 0.22 0.14 0.02 -0.05 0.960 STORAGE AND PROCESSING EcolC_4044 b3981 secE preprotein translocase membrane subunit CELLULAR Intracellular -0.45 -0.22 -0.09 0.14 0.225 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4045 b3339 tufA protein chain elongation factor EF-Tu INFORMATION Translation, 0.43 0.74 -0.18 0.13 0.018 (duplicate of tufB) STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4046 b3974 coaA METABOLISM Coenzyme 0.04 0.28 0.22 0.46 0.099 transport and metabolism EcolC_4047 b3973 birA bifunctional biotin-[acetylCoA METABOLISM Coenzyme 0.37 0.18 0.24 0.05 0.234 carboxylase] holoenzyme synthetase/ transport and DNA-binding transcriptional repressor, metabolism bio-5'-AMP-binding EcolC_4048 b3972 murB UDP-N-acetylenolpyruvoylglucosamine CELLULAR Cell 0.26 0.16 0.35 0.26 0.348 reductase, FAD-binding PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4049 b3967 murI glutamate racemase CELLULAR Cell 0.24 0.65 -0.01 0.40 0.261 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4050 b3966 btuB vitamin B12/cobalamin outer membrane METABOLISM Coenzyme -0.04 0.16 -0.01 0.19 0.429 transporter transport and metabolism EcolC_4051 b3965 trmA tRNA m(5)U54 methyltransferase, SAM- INFORMATION Translation, 0.11 0.24 0.27 0.40 0.796 dependent; tmRNA m(5)U341 STORAGE AND ribosomal methyltransferase PROCESSING structure and biogenesis EcolC_4052 b3964 yijD inner membrane protein, DUF1422 family - - 0.06 -0.16 0.02 -0.20 0.201 EcolC_4053 b3963 fabR DNA-binding transcriptional repressor INFORMATION Transcription 0.45 0.04 0.21 -0.20 0.005 STORAGE AND PROCESSING EcolC_4054 b3962 sthA pyridine nucleotide transhydrogenase, METABOLISM Energy 0.87 -0.21 0.36 -0.73 0.012 soluble production and conversion EcolC_4055 b3961 oxyR oxidative and nitrosative stress INFORMATION Transcription 0.08 0.25 -0.21 -0.04 0.072 transcriptional regulator STORAGE AND PROCESSING EcolC_4056 b3960 argH argininosuccinate lyase METABOLISM Amino acid 0.09 -0.04 0.07 -0.06 0.158 transport and metabolism EcolC_4057 b3959 argB acetylglutamate kinase METABOLISM Amino acid 0.27 0.17 0.39 0.29 0.606 transport and metabolism EcolC_4058 b3958 argC N-acetyl-gamma-glutamylphosphate METABOLISM Amino acid -0.01 -0.07 0.05 -0.01 0.525 reductase, NAD(P)-binding transport and metabolism EcolC_4059 b3957 argE acetylornithine deacetylase METABOLISM Amino acid -0.58 -0.41 -0.17 0.00 0.258 transport and metabolism EcolC_4060 b3956 ppc phosphoenolpyruvate carboxylase METABOLISM Energy -0.73 -0.49 -0.13 0.11 0.115 production and conversion EcolC_4061 b3955 eptC predicted LPS core phosphoethanolamine POORLY General 0.07 0.05 0.23 0.21 0.608 transferase CHARACTERIZ function ED prediction EcolC_4062 b3954 yijO predicted DNA-binding transcriptional CELLULAR Signall 0.15 0.18 0.22 0.25 0.748 regulator PROCESSES transduction AND mechanisms SIGNALING EcolC_4063 b3953 frwD predicted enzyme IIB component of PTS METABOLISM Carbohydrate 0.12 0.05 0.29 0.21 0.547 transport and metabolism EcolC_4064 b3952 pflC pyruvate formate lyase II activase CELLULAR Posttranslatio 0.11 0.35 0.24 0.49 0.510 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4065 b3951 pflD predicted formate acetyltransferase 2 METABOLISM Energy 0.33 0.19 0.04 -0.10 0.458 (pyruvate formate lyase II) production and conversion EcolC_4066 b3950 frwB predicted enzyme IIB component of PTS METABOLISM Carbohydrate 0.31 0.15 0.15 -0.02 0.342 transport and metabolism EcolC_4067 b3949 frwC predicted enzyme IIC component of PTS METABOLISM Carbohydrate 0.47 0.35 0.21 0.09 0.870 transport and metabolism EcolC_4068 b3947 ptsA fused predicted PTS enzymes: Hpr METABOLISM Carbohydrate 0.32 0.36 0.08 0.12 0.907 component/enzyme I component/enzyme transport and IIA component metabolism EcolC_4069 b3946 fsaB fructose-6-phosphate aldolase 2 METABOLISM Carbohydrate 0.07 0.66 -0.04 0.56 0.020 transport and metabolism EcolC_4070 b3945 gldA glycerol dehydrogenase, NAD METABOLISM Energy -1.47 -0.71 -0.18 0.58 0.026 production and conversion EcolC_4071 b3944 yijF conserved protein POORLY Function 0.33 0.35 0.57 0.59 0.870 CHARACTERIZ unknown ED EcolC_4072 b3943 yijE inner membrane protein, predicted POORLY General 0.00 0.05 0.06 0.11 0.526 permease CHARACTERIZ function ED prediction EcolC_4073 b3942 katG catalase-peroxidase HPI, heme b- METABOLISM Inorganicl ion -2.28 -2.73 0.11 -0.34 0.127 containing transport and metabolism EcolC_4074 b3941 metF 5,10-methylenetetrahydrofolate reductase METABOLISM Amino acid -0.01 -0.03 0.16 0.14 0.535 transport and metabolism EcolC_4075 b3940 metL fused aspartokinase II/homoserine METABOLISM Amino acid 0.17 0.06 0.17 0.07 0.279 dehydrogenase II transport and metabolism EcolC_4076 b3939 metB cystathionine gamma-synthase, PLP- METABOLISM Amino acid 0.31 0.38 0.06 0.13 0.718 dependent transport and metabolism EcolC_4077 b3938 metJ DNA-binding transcriptional repressor, S- INFORMATION Transcription -0.01 0.06 0.13 0.20 0.593 adenosylmethionine-binding STORAGE AND PROCESSING EcolC_4078 b3937 yiiX putative lipid binding hydrolase, DUF830 POORLY Function 0.06 0.12 0.24 0.30 0.801 family, function unknown CHARACTERIZ unknown ED EcolC_4082 b3936 rpmE 50S ribosomal subunit protein L31 INFORMATION Translation, -1.46 -1.02 0.01 0.46 0.095 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4083 b3935 priA Primosome factor n' (replication factor Y) INFORMATION Replication, 0.17 0.11 0.36 0.30 0.703 STORAGE AND recombination PROCESSING and repair EcolC_4084 b3934 cytR Anti-activator for CytR-CRP nucleoside INFORMATION Transcription 1.13 0.79 0.22 -0.12 0.579 utilization regulon STORAGE AND PROCESSING EcolC_4085 b3933 ftsN essential cell division protein CELLULAR Cell cycle 0.43 0.56 0.23 0.36 0.395 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_4086 b3932 hslV peptidase component of the HslUV CELLULAR Posttranslati 0.91 0.69 -0.12 -0.34 0.072 protease PROCESSES onal AND modification, SIGNALING protein turnover, chaperones EcolC_4087 b3931 hslU molecular chaperone and ATPase CELLULAR Posttranslatio 0.38 0.16 0.07 -0.15 0.112 component of HslUV protease PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4088 b3930 menA 1,4-dihydroxy-2-naphthoate METABOLISM Coenzyme 0.14 0.21 0.18 0.25 0.946 octaprenyltransferase transport and metabolism EcolC_4089 b3929 rraA (RNase E) inhibitor protein METABOLISM Coenzyme -0.91 -0.48 0.29 0.72 0.312 transport and metabolism EcolC_4090 b3928 zapB FtsZ stabilizer; septal ring assembly factor, POORLY Function 0.13 0.08 0.20 0.16 0.784 stimulates cell division CHARACTERIZ unknown ED EcolC_4091 b3927 glpF glycerol facilitator METABOLISM Carbohydrate 3.28 2.02 0.62 -0.65 0.011 transport and metabolism EcolC_4092 b3926 glpK METABOLISM Energy 2.49 1.96 0.26 -0.27 0.032 production and conversion EcolC_4093 b3925 glpX fructose 1,6-bisphosphatase II METABOLISM Carbohydrate 2.03 1.62 0.39 -0.01 0.035 transport and metabolism EcolC_4094 b3924 fpr ferredoxin-NADP reductase METABOLISM Energy 0.53 0.43 0.26 0.16 0.981 production and conversion EcolC_4095 b3923 uspD stress-induced protein CELLULAR Signal -0.45 -0.98 0.21 -0.32 0.073 PROCESSES transduction AND mechanisms SIGNALING EcolC_4096 b3922 yiiS conserved protein, UPF0381 family POORLY Function -0.98 -1.28 0.41 0.11 0.276 CHARACTERIZ unknown ED EcolC_4097 b3921 yiiR predicted inner membrane protein, POORLY Function 0.10 0.22 0.37 0.49 0.589 DUF805 family CHARACTERIZ unknown ED EcolC_4098 b3920 yiiQ conserved protein - - 0.10 0.17 0.24 0.30 0.945 EcolC_4099 b3919 tpiA triosephosphate isomerase METABOLISM Carbohydrate -0.99 -0.01 -0.11 0.88 0.008 transport and metabolism EcolC_4100 b3918 cdh CDP-diacylglycerol phosphotidylhydrolase METABOLISM Lipid -0.15 -0.02 -0.05 0.07 0.696 transport and metabolism EcolC_4101 b3917 sbp sulfate transporter subunit METABOLISM Inorganic ion 0.14 0.02 0.21 0.10 0.153 transport and metabolism EcolC_4102 b3916 pfkA 6-phosphofructokinase I METABOLISM Carbohydrate -0.47 -0.35 0.11 0.23 0.770 transport and metabolism EcolC_4103 b3915 fieF ferrous iron and zinc transporter METABOLISM Inorganic ion 0.05 -0.07 -0.12 -0.23 0.499 transport and metabolism EcolC_4104 b4484 cpxP inhibitor of the cpx response; periplasmic CELLULAR Intracellular 0.86 0.61 0.46 0.22 0.431 adaptor protein PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4105 b3912 cpxR DNA-binding response regulator in two- CELLULAR Signal -0.38 -0.41 0.01 -0.02 0.741 component regulatory system with CpxA PROCESSES transduction AND mechanisms SIGNALING EcolC_4106 b3911 cpxA sensory histidine kinase in two-component CELLULAR Signal -0.85 -0.96 -0.01 -0.11 0.874 regulatory system with CpxR PROCESSES transduction AND mechanisms SIGNALING EcolC_4108 b3909 kdgT 2-keto-3-deoxy-D-gluconate transporter - - 0.20 0.09 0.24 0.12 0.991 EcolC_4109 b3908 sodA superoxide dismutase, Mn METABOLISM Inorganic ion 0.10 0.33 -1.06 -0.83 0.268 transport and metabolism EcolC_4110 b3907 rhaT L-rhamnose:proton symporter - - -2.66 -0.22 -2.72 -0.28 0.004 EcolC_4111 b3906 rhaR DNA-binding transcriptional activator for INFORMATION Transcription -2.36 -0.29 -2.37 -0.30 0.002 rhaSR, L-rhamnose-binding STORAGE AND PROCESSING EcolC_4112 b3905 rhaS DNA-binding transcriptional activator for INFORMATION Transcription 0.70 0.69 -0.26 -0.26 0.754 rhaBAD and rhaT, L-rhamnose-binding STORAGE AND PROCESSING EcolC_4113 b3904 rhaB rhamnulokinase METABOLISM Carbohydrate -2.93 -0.59 -2.90 -0.55 0.001 transport and metabolism EcolC_4114 b3903 rhaA L-rhamnose isomerase METABOLISM Carbohydrate -2.63 -0.68 -2.88 -0.93 0.003 transport and metabolism EcolC_4115 b3902 rhaD rhamnulose-1-phosphate aldolase METABOLISM Carbohydrate -1.90 -0.04 -1.74 0.13 0.000 transport and metabolism EcolC_4116 b3901 rhaM L-rhamnose mutarotase POORLY Function -0.59 0.38 -0.73 0.23 0.002 CHARACTERIZ unknown ED EcolC_4117 b3900 frvA predicted enzyme IIA component of PTS METABOLISM Carbohydrate -0.16 -0.01 0.08 0.23 0.311 transport and metabolism EcolC_4118 b3899 frvB fused predicted PTS enzymes: IIB METABOLISM Carbohydrate -0.10 -0.36 -0.08 -0.35 0.080 component/IIC component transport and metabolism EcolC_4119 b3898 frvX predicted peptidase METABOLISM Carbohydrate 0.22 0.10 0.06 -0.06 0.343 transport and metabolism EcolC_4120 b3897 frvR putative frv operon regulator; contains a INFORMATION Transcription 0.16 0.02 0.13 -0.01 0.206 PTS EIIA domain STORAGE AND PROCESSING EcolC_4121 b3896 yiiG conserved lipoprotein - - 0.02 0.06 -0.09 -0.05 0.780 EcolC_4122 b3895 fdhD formate dehydrogenase formation protein METABOLISM Energy 0.10 0.16 0.53 0.59 0.909 production and conversion EcolC_4123 b3894 fdoG formate dehydrogenase-O, large subunit METABOLISM Energy 0.11 -0.96 0.57 -0.49 0.003 production and conversion EcolC_4125 b3893 fdoH formate dehydrogenase-O, Fe-S subunit METABOLISM Energy 0.65 -1.13 0.55 -1.23 0.001 production and conversion EcolC_4126 b3892 fdoI formate dehydrogenase-O, cytochrome METABOLISM Energy 0.26 -0.66 0.48 -0.45 0.009 b556 subunit production and conversion EcolC_4127 b3891 fdhE formate dehydrogenase formation protein CELLULAR Posttranslatio 0.67 0.23 0.20 -0.24 0.015 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4128 b3890 yiiF conserved protein - - 0.10 -0.04 0.20 0.07 0.484 EcolC_4129 b3889 yiiE predicted transcriptional regulator - - 0.23 0.56 0.31 0.64 0.357 EcolC_4131 b3887 dtd D-tyr-tRNA(Tyr) deacylase INFORMATION Translation, -0.49 -0.48 0.09 0.10 0.427 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4132 b3886 yihY predicted inner membrane protein POORLY Function -0.27 -0.11 0.03 0.19 0.336 CHARACTERIZ unknown ED EcolC_4133 b3885 yihX alpha-D-Glucose-1-P phosphatase, anomer- POORLY General -0.41 -0.36 -0.17 -0.12 0.742 specific CHARACTERIZ function ED prediction EcolC_4142 b3874 yihN inner membrane protein, predicted METABOLISM Carbohydratel 0.41 0.35 0.33 0.27 0.314 transporter transport and metabolism EcolC_4143 b3873 yihM predicted sugar phosphate isomerase METABOLISM Carbohydrate 0.37 0.64 0.45 0.72 0.219 transport and metabolism EcolC_4144 b3872 yihL predicted DNA-binding transcriptional INFORMATION Transcription 0.62 0.61 0.53 0.53 0.953 regulator STORAGE AND PROCESSING EcolC_4145 b3871 typA GTP-binding protein CELLULAR Signal 0.30 0.06 0.25 0.01 0.213 PROCESSES transduction AND mechanisms SIGNALING EcolC_4146 b3870 glnA glutamine synthetase METABOLISM Amino acid 0.22 0.35 -0.31 -0.18 0.393 transport and metabolism EcolC_4147 b3869 glnL sensory histidine kinase in two-component CELLULAR Signal -0.04 0.11 0.20 0.35 0.363 regulatory system with GlnG PROCESSES transduction AND mechanisms SIGNALING EcolC_4148 b3868 glnG fused DNA-binding response regulator in CELLULAR Signal -0.29 0.19 -0.04 0.44 0.123 two-component regulatory system with PROCESSES transduction GlnL: response regulator/sigma54 AND mechanisms interaction protein SIGNALING EcolC_4149 b3867 hemN coproporphyrinogen III oxidase, SAM and METABOLISM Coenzyme -0.07 -0.10 0.09 0.06 0.733 NAD(P)H dependent, oxygen-independent transport and metabolism EcolC_4150 b3866 yihI activator of Der GTPase POORLY Function -0.25 -0.58 0.26 -0.08 0.154 CHARACTERIZ unknown ED EcolC_4151 b3865 yihA GTP-binding protein required for normal POORLY General 0.04 -0.01 -0.07 -0.13 0.922 cell division CHARACTERIZ function ED prediction EcolC_4152 b3863 polA fused DNA polymerase I 5'->3' INFORMATION Replication,l -0.05 -0.05 -0.08 -0.08 0.400 polymerase/3'->5' exonuclease/5'->3' STORAGE AND recombination exonuclease PROCESSING and repair EcolC_4153 b3862 yihG inner membrane protein, Predicted METABOLISM Lipid 0.03 0.04 0.21 0.22 0.889 acyltransferas transport and metabolism EcolC_4154 b3861 yihF conserved protein, DUF945 family POORLY Function -0.11 -0.11 0.06 0.06 0.589 CHARACTERIZ unknown ED EcolC_4155 b3860 dsbA periplasmic protein disulfide isomerase I CELLULAR Posttranslatio 0.65 0.26 0.37 -0.02 0.234 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4156 b3859 srkA stress response kinase A; MazF antagonist; POORLY General 0.35 0.53 0.18 0.36 0.893 Thr/Ser kinase involved in Cpx stress CHARACTERIZ function response ED prediction EcolC_4157 b3858 yihD DUF1040 protein YihD POORLY Functionl -0.13 0.27 -0.06 0.33 0.062 CHARACTERIZ unknown ED EcolC_4158 b3857 mobA molybdopterin-guanine dinucleotide METABOLISM Coenzyme 0.23 0.23 0.44 0.44 0.949 synthase transport and metabolism EcolC_4159 b3856 mobB molybdopterin-guanine dinucleotide METABOLISM Coenzyme -0.07 0.09 0.24 0.41 0.990 biosynthesis protein B transport and metabolism EcolC_4160 b3850 hemG protoporphyrin oxidase, flavoprotein METABOLISM Energy -0.28 -0.05 0.20 0.43 0.031 production and conversion EcolC_4161 b3849 trkH potassium transporter METABOLISM Inorganic ion -0.25 0.01 -0.17 0.09 0.074 transport and metabolism EcolC_4162 b3848 yigZ conserved protein, UPF0029 family POORLY Function 0.15 0.16 0.23 0.24 0.438 CHARACTERIZ unknown ED EcolC_4163 b3847 pepQ proline dipeptidase METABOLISM Amino acid -0.73 -0.70 0.14 0.17 0.842 transport and metabolism EcolC_4164 b3846 fadB fused 3-hydroxybutyryl-CoA METABOLISM Lipid 0.65 -0.10 0.09 -0.66 0.055 epimerase/delta(3)-cis-delta(2)-trans-enoyl- transport and CoA isomerase/enoyl-CoA hydratase/3- metabolism hydroxyacyl-CoA dehydrogenase

EcolC_4165 b3845 fadA 3-ketoacyl-CoA thiolase (thiolase I) METABOLISM Lipid 0.10 0.07 0.13 0.11 0.666 transport and metabolism EcolC_4166 b3844 fre NAD(P)H-flavin reductase METABOLISM Coenzyme 0.26 0.04 0.11 -0.12 0.144 transport and metabolism EcolC_4167 b3843 ubiD 3-octaprenyl-4-hydroxybenzoate METABOLISM Coenzyme 0.01 0.20 0.02 0.22 0.240 decarboxylase transport and metabolism EcolC_4168 b3842 rfaH DNA-binding transcriptional antiterminator INFORMATION Transcription 0.20 0.72 0.19 0.72 0.441 STORAGE AND PROCESSING EcolC_4169 b4483 tatD quality control of Tat-exported FeS INFORMATION Replication, 0.91 1.06 0.34 0.49 0.373 proteins; Mg-dependent cytoplasmic STORAGE AND recombination DNase PROCESSING and repair EcolC_4170 b3839 tatC TatABCE protein translocation system CELLULAR Intracellular 0.16 0.29 -0.02 0.11 0.462 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4171 b3838 tatB TatABCE protein translocation system CELLULAR Intracellular -0.45 -0.03 -0.06 0.36 0.033 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4172 b3836 tatA TatABCE protein translocation system CELLULAR Intracellular -0.32 -0.17 -0.07 0.08 0.230 subunit PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4173 b3835 ubiB 2-octaprenylphenol hydroxylase POORLY General 0.83 0.73 0.39 0.29 0.328 CHARACTERIZ function ED prediction EcolC_4174 b3834 yigP conserved protein, SCP2 family POORLY Functionl 0.64 0.21 0.08 -0.35 0.036 CHARACTERIZ unknown ED EcolC_4175 b3833 ubiE bifunctional 2-octaprenyl-6-methoxy-1,4- METABOLISM Coenzyme 0.21 0.24 -0.05 -0.01 0.923 benzoquinone methylase/ S- transport and adenosylmethionine:2-DMK metabolism methyltransferase EcolC_4176 b3832 rmuC predicted recombination limiting protein POORLY Function 1.47 0.88 0.18 -0.40 0.060 CHARACTERIZ unknown ED EcolC_4177 b3831 udp uridine phosphorylase METABOLISM Nucleotide 0.51 0.83 0.19 0.51 0.254 transport and metabolism EcolC_4178 b3830 ysgA predicted hydrolase METABOLISM Secondary 0.65 -0.10 0.14 -0.61 0.042 metabolites biosynthesis, transport and catabolism EcolC_4181 b3827 yigM predicted inner membrane protein METABOLISM Carbohydrate 0.26 0.07 0.24 0.04 0.312 transport and metabolism EcolC_4182 b3826 yigL predicted hydrolase POORLY General 0.02 -0.02 0.04 0.00 0.856 CHARACTERIZ function ED prediction EcolC_4183 b3825 pldB lysophospholipase L2 METABOLISM Lipidl 0.46 0.42 0.17 0.13 0.946 transport and metabolism EcolC_4184 b3824 rhtB homoserine, homoserine lactone and S- METABOLISM Amino acid 0.25 0.47 0.14 0.36 0.970 methyl-methionine efflux pump transport and metabolism EcolC_4185 b3823 rhtC threonine efflux pump METABOLISM Amino acid 0.07 0.18 0.37 0.48 0.194 transport and metabolism EcolC_4187 b3821 pldA outer membrane phospholipase A CELLULAR Cell -0.02 0.15 -0.06 0.11 0.325 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4188 b3820 yigI conserved protein, 4HBT family of METABOLISM Secondary 0.19 -0.22 0.00 -0.42 0.095 metabolites biosynthesis, transport and catabolism EcolC_4189 b3819 rarD predicted chloramphenical resistance POORLY General 0.20 0.29 0.34 0.44 0.234 permease CHARACTERIZ function ED prediction EcolC_4190 b3818 yigG conserved inner membrane protein - -l -0.08 -0.27 -0.03 -0.22 0.092 EcolC_4191 b3817 yigF predicted inner membrane protein - - -0.07 -0.10 -0.08 -0.11 0.742 EcolC_4192 b3816 corA magnesium/nickel/cobalt transporter METABOLISM Inorganic ion 0.00 0.07 0.25 0.32 0.787 transport and metabolism EcolC_4193 b4482 yigE predicted protein, DUF2233 family POORLY Function 0.06 -0.05 -0.01 -0.12 0.372 CHARACTERIZ unknown ED EcolC_4194 b3813 uvrD DNA-dependent ATPase I and helicase II INFORMATION Replication, -0.10 -0.11 0.25 0.24 0.761 STORAGE AND recombination PROCESSING and repair EcolC_4195 b3812 yigB FMN phosphatase POORLY General 0.49 0.66 0.16 0.33 0.391 CHARACTERIZ function ED prediction EcolC_4196 b3811 xerC site-specific tyrosine recombinase INFORMATION Replication,l 0.06 0.50 0.11 0.56 0.066 STORAGE AND recombination PROCESSING and repair EcolC_4197 b3810 yigA conserved protein, DUF484 family POORLY Function 0.15 0.54 0.27 0.67 0.020 CHARACTERIZ unknown ED EcolC_4198 b3809 dapF diaminopimelate epimerase METABOLISM Amino acid -0.02 0.26 0.12 0.40 0.020 transport and metabolism EcolC_4199 b4558 yifL predicted lipoprotein CELLULAR Cell motility -0.38 -0.03 -0.08 0.26 0.135 PROCESSES AND SIGNALING EcolC_4200 b3807 cyaY iron-dependent inhibitor of iron-sulfur METABOLISM Inorganic ion 0.32 0.36 -0.07 -0.04 0.620 cluster formation; frataxin; iron-binding transport and and oxidizing protein metabolism EcolC_4201 b3806 cyaA adenylate cyclase METABOLISM Nucleotide -0.22 -0.45 0.40 0.17 0.357 transport and metabolism EcolC_4202 b3805 hemC hydroxymethylbilane synthase METABOLISM Coenzyme -0.37 0.56 -0.06 0.87 0.005 transport and metabolism EcolC_4203 b3804 hemD uroporphyrinogen III synthase METABOLISM Coenzyme 0.13 0.06 0.12 0.05 0.415 transport and metabolism EcolC_4204 b3803 hemX predicted uroporphyrinogen III METABOLISM Coenzyme -0.35 -0.17 -0.21 -0.03 0.143 methyltransferase transport and metabolism EcolC_4206 b3800 aslB predicted regulator of activity POORLY General 0.67 -0.06 -0.04 -0.77 0.125 CHARACTERIZ function ED prediction EcolC_4207 b3795 yifK predicted transporter METABOLISM Aminol acid 0.10 0.08 0.23 0.21 0.420 transport and metabolism EcolC_4208 b3794 wecG UDP-N-acetyl-D-mannosaminuronic acid CELLULAR Cell 0.08 -0.02 0.18 0.09 0.644 transferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4209 b3793 wzyE predicted Wzy protein involved in ECA - - -0.09 -0.07 0.01 0.03 0.894 polysaccharide chain elongation EcolC_4210 b4481 wecF TDP-Fuc4NAc:lipidIIFuc4NAc transferase - - 0.00 0.28 0.14 0.42 0.444

EcolC_4211 b3792 wzxE O-antigen translocase - - 0.03 0.21 -0.01 0.17 0.153 EcolC_4212 b3791 wecE TDP-4-oxo-6-deoxy-D-glucose CELLULAR Cell -0.03 -0.12 0.01 -0.08 0.907 transaminase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4213 b3790 wecD TDP-fucosamine acetyltransferase - - 0.01 0.07 0.04 0.10 0.650 EcolC_4214 b3789 rffH glucose-1-phosphate thymidylyltransferase CELLULAR Cell -0.25 0.15 -0.53 -0.13 0.143 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4215 b3788 rffG dTDP-glucose 4,6-dehydratase CELLULAR Cell -0.03 0.02 -0.14 -0.09 0.784 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4216 b3787 wecC UDP-N-acetyl-D-mannosaminuronic acid CELLULAR Cell 0.06 0.03 -0.29 -0.33 0.946 dehydrogenase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4217 b3786 wecB UDP-N-acetyl glucosamine-2-epimerase CELLULAR Cell 0.10 0.04 -0.05 -0.11 0.716 PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4218 b3785 wzzE Entobacterial Common Antigen (ECA) CELLULAR Cell 0.10 0.28 -0.14 0.04 0.974 polysaccharide chain length modulation PROCESSES wall/membran protein AND e/envelope SIGNALING biogenesis EcolC_4219 b3784 wecA UDP-GlcNAc:undecaprenylphosphate CELLULAR Cell -0.01 0.41 -0.04 0.38 0.514 GlcNAc-1-phosphate transferase PROCESSES wall/membra AND ne/envelope SIGNALING biogenesis EcolC_4220 b3783 rho transcription termination factor INFORMATION Transcription 0.38 0.88 0.33 0.82 0.220 STORAGE AND PROCESSING EcolC_4222 b3781 trxA thioredoxin 1 CELLULAR Posttranslatio -0.25 -0.23 -0.04 -0.03 0.961 PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4223 b3780 rhlB ATP-dependent RNA helicase INFORMATION Replication, -0.22 -0.03 0.11 0.30 0.169 STORAGE AND recombination PROCESSING and repair EcolC_4224 b3779 gpp guanosine METABOLISM Nucleotide 0.20 0.20 0.06 0.06 0.594 pentaphosphatase/exopolyphosphatase transport and metabolism EcolC_4225 b3778 rep DNA helicase and single-stranded DNA- INFORMATION Replication, 0.48 0.39 0.34 0.25 0.941 dependent ATPase STORAGE AND recombination PROCESSING and repair EcolC_4227 b3775 ppiC peptidyl-prolyl cis-trans isomerase C CELLULAR Posttranslatio 0.26 0.47 0.40 0.61 0.105 (rotamase C) PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4228 b3774 ilvC ketol-acid reductoisomerase, NAD(P)- METABOLISM Amino acid -1.50 -1.43 -0.30 -0.23 0.295 binding transport and metabolism EcolC_4229 b3773 ilvY DNA-binding transcriptional dual regulator INFORMATION Transcription 0.54 0.72 0.43 0.61 0.353 STORAGE AND PROCESSING EcolC_4230 b3772 ilvA threonine deaminase METABOLISM Amino acid -0.26 -0.28 0.07 0.05 0.823 transport and metabolism EcolC_4231 b3771 ilvD dihydroxyacid dehydratase METABOLISM Amino acid -0.93 -0.98 0.01 -0.04 0.676 transport and metabolism EcolC_4233 b3769 ilvM acetolactate synthase II, small subunit POORLY Function -1.58 -0.98 -0.42 0.19 0.048 CHARACTERIZ unknown ED EcolC_4235 b3766 ilvL ilvG operon leader peptide - - 0.04 0.04 0.29 0.28 0.827 EcolC_4236 b3765 yifB predicted bifunctional enzyme and CELLULAR Posttranslatio 0.64 0.34 0.35 0.05 0.790 transcriptional regulator PROCESSES nal AND modification, SIGNALING protein turnover, chaperones EcolC_4237 b3764 yifE conserved protein, UPF0438 family POORLY Function 0.30 0.26 0.42 0.38 0.904 CHARACTERIZ unknown ED EcolC_4238 b4480 hdfR DNA-binding transcriptional regulator INFORMATION Transcription 0.12 -0.29 0.21 -0.21 0.147 STORAGE AND PROCESSING EcolC_4239 b3755 yieP predicted transcriptional regulator INFORMATION Transcription -1.02 -0.38 -0.09 0.56 0.008 STORAGE AND PROCESSING EcolC_4240 b3754 hsrA predicted multidrug or homocysteine efflux METABOLISM Carbohydrate -0.73 -0.50 -0.14 0.08 0.475 system transport and metabolism EcolC_4241 b3753 rbsR DNA-binding transcriptional repressor of INFORMATION Transcription 0.93 0.92 0.25 0.24 0.846 ribose metabolism STORAGE AND PROCESSING EcolC_4242 b3752 rbsK ribokinase METABOLISM Carbohydrate 1.28 0.87 -0.15 -0.57 0.017 transport and metabolism EcolC_4243 b3751 rbsB D-ribose transporter subunit METABOLISM Carbohydrate 1.48 0.58 -0.15 -1.05 0.077 transport and metabolism EcolC_4244 b3750 rbsC D-ribose transporter subunit METABOLISM Carbohydrate 1.07 0.58 0.13 -0.36 0.076 transport and metabolism EcolC_4245 b3749 rbsA fused D-ribose transporter subunits of ABC METABOLISM Carbohydrate 1.97 0.91 0.30 -0.76 0.030 superfamily: ATP-binding components transport and metabolism EcolC_4246 b3748 rbsD predicted cytoplasmic sugar-binding METABOLISM Carbohydrate 0.95 0.13 0.21 -0.61 0.034 protein transport and metabolism EcolC_4247 b3747 kup potassium transporter METABOLISM Inorganic ion 0.01 0.08 0.04 0.11 0.955 transport and metabolism EcolC_4248 b3746 ravA fused predicted transcriptional regulator: POORLY General -0.75 -0.59 0.27 0.43 0.108 sigma54 activator protein/conserved CHARACTERIZ function protein ED prediction EcolC_4249 b3745 viaA predicted von Willibrand factor containing POORLY Generall 0.22 0.21 0.27 0.26 0.842 protein CHARACTERIZ function ED prediction EcolC_4250 b3744 asnA asparagine synthetase A METABOLISM Aminol acid -0.81 -0.54 -0.58 -0.31 0.288 transport and metabolism EcolC_4251 b3743 asnC DNA-binding transcriptional dual regulator INFORMATION Transcription -0.01 -0.12 0.31 0.20 0.663 STORAGE AND PROCESSING EcolC_4252 b3742 mioC FMN-binding protein MioC METABOLISM Energy -0.92 -0.07 -0.06 0.79 0.058 production and conversion EcolC_4253 b3741 mnmG 5-methylaminomethyl-2-thiouridine CELLULAR Cell cycle 0.15 0.55 0.32 0.72 0.273 modification at tRNA U34 PROCESSES control, cell AND division, SIGNALING chromosome partitioning EcolC_4254 b3740 rsmG 16S rRNA m(7)G527 methyltransferase, CELLULAR Cell 0.13 0.31 0.26 0.44 0.767 SAM-dependent; glucose-inhibited cell- PROCESSES wall/membran division protein AND e/envelope SIGNALING biogenesis EcolC_4255 b3739 atpI ATP synthase, membrane-bound accessory METABOLISM Energy -0.05 -0.67 0.02 -0.60 0.005 factor production and conversion EcolC_4256 b3738 atpB F0 sector of membrane-bound ATP METABOLISM Energy -0.32 -0.75 0.09 -0.35 0.347 synthase, subunit a production and conversion EcolC_4257 b3737 atpE F0 sector of membrane-bound ATP METABOLISM Energy -0.82 -0.38 0.24 0.67 0.734 synthase, subunit c production and conversion EcolC_4258 b3736 atpF F0 sector of membrane-bound ATP METABOLISM Energy -0.09 -0.64 0.14 -0.41 0.017 synthase, subunit b production and conversion EcolC_4259 b3735 atpH F1 sector of membrane-bound ATP METABOLISM Energy -0.80 -1.15 0.27 -0.08 0.169 synthase, delta subunit production and conversion EcolC_4260 b3734 atpA F1 sector of membrane-bound ATP METABOLISM Energy -1.31 -0.89 0.14 0.56 0.239 synthase, alpha subunit production and conversion EcolC_4261 b3733 atpG F1 sector of membrane-bound ATP METABOLISM Energy -1.09 -1.09 0.08 0.08 0.843 synthase, gamma subunit production and conversion EcolC_4262 b3732 atpD F1 sector of membrane-bound ATP METABOLISM Energy -1.37 -1.54 0.20 0.02 0.800 synthase, beta subunit production and conversion EcolC_4263 b3731 atpC F1 sector of membrane-bound ATP METABOLISM Energy 0.13 0.26 0.64 0.77 0.620 synthase, epsilon subunit production and conversion EcolC_4264 b3730 glmU fused N-acetyl glucosamine-1-phosphate CELLULAR Cell -0.66 -0.81 -0.27 -0.42 0.461 uridyltransferase/glucosamine-1-phosphate PROCESSES wall/membran acetyl transferase AND e/envelope SIGNALING biogenesis EcolC_4265 b3729 glmS L-glutamine:D-fructose-6-phosphate CELLULAR Cell -0.59 -0.66 -0.45 -0.52 0.690 aminotransferase PROCESSES wall/membran AND e/envelope SIGNALING biogenesis EcolC_4266 b3728 pstS periplasmic phosphate binding protein, METABOLISM Inorganic ion 0.27 0.55 0.02 0.30 0.216 high-affinity transport and metabolism EcolC_4267 b3727 pstC phosphate transporter subunit METABOLISM Inorganic ion 0.60 0.78 0.56 0.74 0.801 transport and metabolism EcolC_4268 b3726 pstA phosphate transporter subunit METABOLISM Inorganic ion 0.30 0.55 0.31 0.56 0.278 transport and metabolism EcolC_4269 b3725 pstB phosphate transporter subunit METABOLISM Inorganic ion 0.15 0.26 0.17 0.28 0.252 transport and metabolism EcolC_4270 b3724 phoU negative regulator of PhoR/PhoB two- METABOLISM Inorganic ion 0.23 0.21 0.31 0.29 0.824 component regulator transport and metabolism EcolC_4271 b3723 bglG transcriptional antiterminator of the bgl INFORMATION Transcription -0.10 -0.04 0.00 0.06 0.776 operon STORAGE AND PROCESSING EcolC_4272 b3722 bglF fused beta-glucoside-specific PTS METABOLISM Carbohydrate -0.04 -0.26 -0.08 -0.30 0.716 enzymes: IIA component/IIB transport and component/IIC component metabolism EcolC_4273 b3721 bglB cryptic phospho-beta-glucosidase B METABOLISM Carbohydrate 0.00 0.06 0.14 0.20 0.443 transport and metabolism EcolC_4274 b3720 bglH carbohydrate-specific outer membrane METABOLISM Carbohydrate 0.13 0.57 0.14 0.58 0.185 porin, cryptic transport and metabolism EcolC_4276 b3718 yieK predicted 6-phosphogluconolactonase METABOLISM Carbohydrate 0.03 -0.01 0.06 0.01 0.638 transport and metabolism EcolC_4277 b3717 cbrC conserved protein, UPF0167 family POORLY Function 0.19 0.01 0.38 0.20 0.177 CHARACTERIZ unknown ED EcolC_4278 b3716 cbrB inner membrane protein, creBC regulon - - 0.27 0.17 0.21 0.10 0.839 EcolC_4279 b3715 yieH phosphoenolpyruvate and 6- POORLY General -0.04 -0.09 0.19 0.13 0.747 phosphogluconate phosphatase CHARACTERIZ function ED prediction EcolC_4280 b3714 purP adenine permease, high affinity; POORLY Generall -0.24 -0.16 0.02 0.09 0.978 adenine:H+ symporter CHARACTERIZ function ED prediction EcolC_4281 b3713 chrR chromate reductase, Class I, flavoprotein POORLY Generall -0.25 -0.60 0.64 0.28 0.192 CHARACTERIZ function ED prediction EcolC_4282 b3712 yieE predicted phosphopantetheinyl transferase, METABOLISM Coenzymel -0.59 -0.53 0.56 0.61 0.929 COG2091 family transport and metabolism EcolC_4283 b3711 yidZ predicted DNA-binding transcriptional INFORMATION Transcription -0.17 -0.66 0.21 -0.28 0.261 regulator STORAGE AND PROCESSING EcolC_4284 b3710 mdtL multidrug efflux system protein METABOLISM Carbohydrate -0.01 0.24 0.06 0.30 0.229 transport and metabolism EcolC_4286 b3708 tnaA tryptophanase/L-cysteine desulfhydrase, METABOLISM Amino acid 0.12 0.19 -0.06 0.01 0.801 PLP-dependent transport and metabolism EcolC_4287 b3707 tnaC tryptophanase leader peptide - - -0.08 0.00 0.09 0.17 0.613 EcolC_4288 b3706 mnmE GTPase required for 5- POORLY General 0.53 0.47 0.33 0.28 0.962 methylaminomethyl-2-thiouridine CHARACTERIZ function modification at tRNA U34 ED prediction EcolC_4289 b3705 yidC membrane protein insertase CELLULAR Intracellularl 0.58 0.78 0.44 0.64 0.116 PROCESSES trafficking, AND secretion, and SIGNALING vesicular transport EcolC_4290 b4557 yidD membrane protein insertion efficiency POORLY Function -1.44 -0.73 -0.11 0.60 0.060 factor, inner membrane protein, UPF0161 CHARACTERIZ unknown family ED EcolC_4291 b3704 rnpA protein C5 component of RNase P INFORMATION Translation, -1.55 -1.32 -0.16 0.07 0.224 STORAGE AND ribosomal PROCESSING structure and biogenesis EcolC_4292 b3703 rpmH 50S ribosomal subunit protein L34 INFORMATION Translation, -1.75 -1.86 -0.15 -0.25 0.650 STORAGE AND ribosomal PROCESSING structure and biogenesis Supplementary Table S2. Transcript ratios of differentially expressed genes (DEGs). Genes associated with point mutations are in bold (FDR < 0.05).

Locus in E. Log2 (transcript ratio) Region in Locus in E. coli K-12 Name Product COG class COG description Fig. 2 coli C MG1655 A1/A0 E1/E0 E0/A0 E1/A1 FDR

I EcolC_2043 b1587 ynfE putative selenate reductase, METABOLISM Energy production and -2.84 -1.68 -0.25 0.91 0.000 periplasmic conversion I EcolC_3993 b4036 lamB maltose outer membrane porin METABOLISM Carbohydrate transport and -3.07 -1.05 -1.72 0.30 0.001 (maltoporin) metabolism I EcolC_0372 b3341 rpsG 30S ribosomal subunit protein S7 INFORMATION STORAGE AND Translation, ribosomal structure -2.01 -1.13 -0.22 0.65 0.001 PROCESSING and biogenesis I EcolC_3812 b4201 priB primosomal protein N INFORMATION STORAGE AND Replication, recombination and -2.36 -1.15 -0.22 0.99 0.001 PROCESSING repair I EcolC_0400 b3313 rplP 50S ribosomal subunit protein L16 INFORMATION STORAGE AND Translation, ribosomal structure -2.46 -1.18 0.02 1.30 0.001 PROCESSING and biogenesis I EcolC_1959 b1672 ydhW predicted protein - - -2.67 -1.48 -0.04 1.14 0.001 I EcolC_2042 b1588 ynfF S- and N-oxide reductase, A METABOLISM Energy production and -2.85 -1.34 -0.18 1.34 0.001 subunit, periplasmic conversion I EcolC_1957 b1674 ydhY predicted 4Fe-4S ferridoxin-type METABOLISM Energy production and -3.41 -2.15 0.16 1.43 0.001 protein conversion I EcolC_0398 b3315 rplV 50S ribosomal subunit protein L22 INFORMATION STORAGE AND Translation, ribosomal structure -2.92 -1.26 -0.10 1.57 0.002 PROCESSING and biogenesis I EcolC_2041 b1589 ynfG oxidoreductase, Fe-S subunit METABOLISM Energy production and -2.94 -1.30 -0.13 1.50 0.002 conversion I EcolC_0394 b3319 rplD 50S ribosomal subunit protein L4 INFORMATION STORAGE AND Translation, ribosomal structure -3.14 -1.21 -0.18 1.75 0.002 PROCESSING and biogenesis I EcolC_3994 b4035 malK fused maltose transport subunit, METABOLISM Carbohydrate transport and -3.01 -1.02 -1.27 0.72 0.002 ATP-binding component of ABC metabolism superfamily/regulatory protein I EcolC_3992 b4037 malM maltose regulon periplasmic - - -2.98 -1.18 -1.23 0.57 0.003 protein I EcolC_0395 b3318 rplW 50S ribosomal subunit protein L23 INFORMATION STORAGE AND Translation, ribosomal structure -3.19 -1.08 -0.11 1.99 0.003 PROCESSING and biogenesis I EcolC_0417 b3296 rpsD 30S ribosomal subunit protein S4 INFORMATION STORAGE AND Translation, ribosomal structure -2.40 -1.10 0.01 1.31 0.003 PROCESSING and biogenesis I EcolC_1962 b1669 ydhT conserved protein - - -1.93 -1.05 0.39 1.27 0.003 I EcolC_0350 b3362 yhfG predicted Fic-binding protein - - -1.35 -2.11 0.72 -0.04 0.004 I EcolC_4041 b3984 rplA 50S ribosomal subunit protein L1 INFORMATION STORAGE AND Translation, ribosomal structure -2.25 -1.58 -0.15 0.52 0.006 PROCESSING and biogenesis I EcolC_3811 b4202 rpsR 30S ribosomal subunit protein S18 INFORMATION STORAGE AND Translation, ribosomal structure -2.04 -1.29 -0.10 0.65 0.007 PROCESSING and biogenesis I EcolC_2437 b1188 ycgB conserved protein POORLY CHARACTERIZED Function unknown -1.67 -2.46 0.65 -0.15 0.008 I EcolC_0514 b3186 rplU 50S ribosomal subunit protein L21 INFORMATION STORAGE AND Translation, ribosomal structure -1.80 -1.04 -0.19 0.57 0.010 PROCESSING and biogenesis I EcolC_3813 b4200 rpsF 30S ribosomal subunit protein S6 INFORMATION STORAGE AND Translation, ribosomal structure -2.30 -1.23 -0.12 0.96 0.011 PROCESSING and biogenesis I EcolC_0351 b3361 fic stationary-phase adenosine CELLULAR PROCESSES AND Cell cycle control, cell division, -1.69 -2.43 0.71 -0.03 0.011 monophosphate-protein transferase SIGNALING chromosome partitioning domain protein I EcolC_0804 b2905 gcvT aminomethyltransferase, METABOLISM Amino acid transport and -1.74 -1.31 -0.35 0.09 0.014 tetrahydrofolate-dependent, metabolism subunit (T protein) of glycine cleavage complex I EcolC_1961 b1670 ydhU predicted cytochrome METABOLISM Energy production and -1.74 -1.15 0.01 0.61 0.014 conversion I EcolC_1958 b1673 ydhV predicted oxidoreductase METABOLISM Energy production and -3.08 -1.91 0.02 1.20 0.014 conversion I EcolC_3810 b4203 rplI 50S ribosomal subunit protein L9 INFORMATION STORAGE AND Translation, ribosomal structure -2.18 -1.29 -0.09 0.80 0.015 PROCESSING and biogenesis I EcolC_1074 b2609 rpsP 30S ribosomal subunit protein S16 INFORMATION STORAGE AND Translation, ribosomal structure -2.37 -1.43 -0.11 0.84 0.018 PROCESSING and biogenesis I EcolC_0475 b3231 rplM 50S ribosomal subunit protein L13 INFORMATION STORAGE AND Translation, ribosomal structure -2.41 -1.63 -0.09 0.69 0.019 PROCESSING and biogenesis I EcolC_3792 b4214 cysQ PAPS (adenosine 3'-phosphate 5'- METABOLISM Inorganic ion transport and -1.21 -1.56 0.20 -0.15 0.023 phosphosulfate) 3'(2'),5'- metabolism bisphosphate nucleotidase I EcolC_0573 b3127 garP predicted (D)-galactarate METABOLISM Carbohydrate transport and -2.37 -1.11 -0.46 0.80 0.023 transporter metabolism I EcolC_4042 b3983 rplK 50S ribosomal subunit protein L11 INFORMATION STORAGE AND Translation, ribosomal structure -2.90 -2.13 -0.13 0.65 0.026 PROCESSING and biogenesis I EcolC_1113 b2564 pdxJ pyridoxine 5'-phosphate synthase METABOLISM Coenzyme transport and -1.53 -1.35 -0.19 -0.01 0.033 metabolism I EcolC_0399 b3314 rpsC 30S ribosomal subunit protein S3 INFORMATION STORAGE AND Translation, ribosomal structure -2.84 -1.71 -0.01 1.12 0.033 PROCESSING and biogenesis I EcolC_0404 b3309 rplX 50S ribosomal subunit protein L24 INFORMATION STORAGE AND Translation, ribosomal structure -1.50 -1.72 -0.14 -0.36 0.036 PROCESSING and biogenesis I EcolC_0806 b2903 gcvP glycine decarboxylase, PLP- METABOLISM Amino acid transport and -1.61 -1.17 -0.28 0.17 0.039 dependent, subunit (protein P) of metabolism glycine cleavage complex I EcolC_0757 b2957 ansB periplasmic L-asparaginase II METABOLISM Amino acid transport and -3.09 -2.23 -0.12 0.74 0.040 metabolism I EcolC_2831 b0812 dps Fe-binding and storage protein; METABOLISM Inorganic ion transport and -1.26 -2.07 0.28 -0.53 0.044 stress-inducible DNA-binding metabolism protetin I EcolC_0371 b3342 rpsL 30S ribosomal subunit protein S12 INFORMATION STORAGE AND Translation, ribosomal structure -1.95 -1.11 -0.09 0.74 0.046 PROCESSING and biogenesis I EcolC_1034 b2672 ygaM ribosome-binding protein, - - -1.15 -1.50 0.30 -0.05 0.046 probably membrane-anchored, function unknown II EcolC_4115 b3902 rhaD rhamnulose-1-phosphate aldolase METABOLISM Carbohydrate transport and -1.90 -0.04 -1.74 0.13 0.000 metabolism II EcolC_3995 b4034 malE maltose transporter subunit METABOLISM Carbohydrate transport and -1.50 0.91 -1.29 1.11 0.000 metabolism II EcolC_0297 b3416 malQ 4-alpha-glucanotransferase METABOLISM Carbohydrate transport and -2.18 -0.51 -0.37 1.30 0.001 (amylomaltase) metabolism II EcolC_4113 b3904 rhaB rhamnulokinase METABOLISM Carbohydrate transport and -2.93 -0.59 -2.90 -0.55 0.001 metabolism II EcolC_0296 b3417 malP maltodextrin phosphorylase METABOLISM Carbohydrate transport and -2.07 0.03 -0.20 1.90 0.001 metabolism II EcolC_2525 b1075 flgD flagellar hook assembly protein CELLULAR PROCESSES AND Cell motility -1.87 -0.15 -1.49 0.24 0.001 SIGNALING II EcolC_4111 b3906 rhaR DNA-binding transcriptional INFORMATION STORAGE AND Transcription -2.36 -0.29 -2.37 -0.30 0.002 activator for rhaSR, L-rhamnose- PROCESSING binding II EcolC_0985 b2727 hypB GTP hydrolase involved in nickel CELLULAR PROCESSES AND Posttranslational modification, -1.40 -0.24 -0.20 0.96 0.002 liganding into hydrogenases SIGNALING protein turnover, chaperones II EcolC_3996 b4033 malF maltose transporter subunit METABOLISM Carbohydrate transport and -1.64 0.62 -1.08 1.18 0.002 metabolism II EcolC_0586 b4471 tdcG L-serine dehydratase 3 METABOLISM Amino acid transport and -1.84 0.16 -0.57 1.43 0.002 metabolism II EcolC_2701 b0895 dmsB dimethyl sulfoxide reductase, METABOLISM Energy production and -1.72 -0.45 -0.23 1.04 0.002 anaerobic, subunit B conversion II EcolC_0585 b3113 tdcF putative reactive intermediate INFORMATION STORAGE AND Translation, ribosomal structure -2.28 0.02 -0.42 1.88 0.002 deaminase PROCESSING and biogenesis II EcolC_0984 b2728 hypC protein required for maturation of CELLULAR PROCESSES AND Posttranslational modification, -1.49 0.10 -0.06 1.52 0.002 hydrogenases 1 and 3 SIGNALING protein turnover, chaperones II EcolC_0983 b2729 hypD protein required for maturation of CELLULAR PROCESSES AND Posttranslational modification, -1.22 -0.04 -0.10 1.08 0.002 hydrogenases SIGNALING protein turnover, chaperones II EcolC_4114 b3903 rhaA L-rhamnose isomerase METABOLISM Carbohydrate transport and -2.63 -0.68 -2.88 -0.93 0.003 metabolism II EcolC_3997 b4032 malG maltose transporter subunit METABOLISM Carbohydrate transport and -1.07 0.61 -0.74 0.94 0.003 metabolism II EcolC_0396 b3317 rplB 50S ribosomal subunit protein L2 INFORMATION STORAGE AND Translation, ribosomal structure -2.72 -0.95 -0.06 1.71 0.003 PROCESSING and biogenesis II EcolC_0986 b2726 hypA protein involved in nickel insertion POORLY CHARACTERIZED General function prediction only -1.58 -0.10 -0.08 1.40 0.003 into hydrogenases 3 II EcolC_0393 b3320 rplC 50S ribosomal subunit protein L3 INFORMATION STORAGE AND Translation, ribosomal structure -3.11 -0.93 -0.13 2.05 0.003 PROCESSING and biogenesis II EcolC_2700 b0896 dmsC dimethyl sulfoxide reductase, POORLY CHARACTERIZED General function prediction only -1.68 -0.42 -0.09 1.17 0.003 anaerobic, subunit C II EcolC_4110 b3907 rhaT L-rhamnose:proton symporter - - -2.66 -0.22 -2.72 -0.28 0.004 II EcolC_2523 b1077 flgF flagellar component of cell- CELLULAR PROCESSES AND Cell motility -1.71 -0.14 -1.17 0.40 0.005 proximal portion of basal-body rod SIGNALING II EcolC_0392 b3321 rpsJ 30S ribosomal subunit protein S10 INFORMATION STORAGE AND Translation, ribosomal structure -2.72 -0.65 -0.05 2.02 0.005 PROCESSING and biogenesis II EcolC_0829 b2879 ssnA predicted METABOLISM Nucleotide transport and -1.26 -0.12 0.59 1.72 0.005 chlorohydrolase/aminohydrolase metabolism II EcolC_0096 b3612 gpmM phosphoglycero mutase III, METABOLISM Carbohydrate transport and -1.28 -0.26 0.21 1.23 0.005 cofactor-independent metabolism II EcolC_1358 b2294 yfbU conserved protein, UPF0304 POORLY CHARACTERIZED Function unknown -1.09 -0.58 -0.24 0.28 0.005 family II EcolC_1075 b2608 rimM 16S rRNA processing protein INFORMATION STORAGE AND Translation, ribosomal structure -1.59 -0.90 -0.18 0.51 0.005 PROCESSING and biogenesis II EcolC_3905 b4122 fumB anaerobic class I fumarate METABOLISM Energy production and -1.18 0.04 -1.56 -0.34 0.006 hydratase (fumarase B) conversion II EcolC_2702 b0894 dmsA dimethyl sulfoxide reductase, METABOLISM Energy production and -1.58 -0.37 -0.30 0.91 0.006 anaerobic, subunit A conversion II EcolC_4239 b3755 yieP predicted transcriptional regulator INFORMATION STORAGE AND Transcription -1.02 -0.38 -0.09 0.56 0.008 PROCESSING II EcolC_1198 b2478 dapA dihydrodipicolinate synthase METABOLISM Amino acid transport and -1.09 -0.26 -0.05 0.78 0.009 metabolism II EcolC_3768 b4243 ridA conserved protein, UPF0131 INFORMATION STORAGE AND Translation, ribosomal structure -1.00 -0.26 -0.31 0.44 0.010 family PROCESSING and biogenesis II EcolC_0397 b3316 rpsS 30S ribosomal subunit protein S19 INFORMATION STORAGE AND Translation, ribosomal structure -3.33 -0.99 -0.10 2.23 0.011 PROCESSING and biogenesis II EcolC_3481 b0179 lpxD UDP-3-O-(3-hydroxymyristoyl)- CELLULAR PROCESSES AND Cell wall/membrane/envelope -1.26 -0.64 -0.14 0.48 0.013 glucosamine N-acyltransferase SIGNALING biogenesis II EcolC_0298 b3415 gntT gluconate transporter, high-affinity METABOLISM Carbohydrate transport and -1.64 -0.29 -0.02 1.33 0.013 GNT I system metabolism II EcolC_0658 b3040 zupT zinc transporter METABOLISM Inorganic ion transport and -1.00 0.00 0.73 1.73 0.013 metabolism II EcolC_3023 b0621 dcuC anaerobic C4-dicarboxylate METABOLISM Energy production and -1.13 -0.17 -0.46 0.50 0.018 transport conversion II EcolC_0279 b3433 asd aspartate-semialdehyde METABOLISM Amino acid transport and -1.49 -0.05 0.05 1.49 0.018 dehydrogenase, NAD(P)-binding metabolism II EcolC_0454 b3253 acuI predicted acryloyl-CoA reductase METABOLISM Energy production and -1.16 -0.63 -0.18 0.35 0.020 conversion II EcolC_1359 b2293 yfbT sugar phosphatas POORLY CHARACTERIZED General function prediction only -1.07 -0.14 -0.21 0.72 0.024 II EcolC_4070 b3945 gldA glycerol dehydrogenase, NAD METABOLISM Energy production and -1.47 -0.71 -0.18 0.58 0.026 conversion II EcolC_0572 b3128 garD (D)-galactarate dehydrogenase METABOLISM Carbohydrate transport and -1.52 -0.51 -0.64 0.38 0.032 metabolism II EcolC_1178 b2498 upp uracil phosphoribosyltransferase METABOLISM Nucleotide transport and -1.19 -0.47 -0.24 0.49 0.033 metabolism II EcolC_2040 b1590 ynfH oxidoreductase, membrane subunit POORLY CHARACTERIZED General function prediction only -1.65 -0.90 -0.12 0.63 0.036

II EcolC_2524 b1076 flgE flagellar hook protein CELLULAR PROCESSES AND Cell motility -1.42 0.08 -1.17 0.33 0.036 SIGNALING II EcolC_3907 b4120 melB melibiose:sodium symporter METABOLISM Carbohydrate transport and -1.00 -0.43 0.01 0.58 0.037 metabolism II EcolC_2480 b1123 potD polyamine transporter subunit METABOLISM Amino acid transport and -1.03 -0.52 -0.38 0.13 0.039 metabolism II EcolC_0518 b3182 dacB D-alanyl-D-alanine CELLULAR PROCESSES AND Cell wall/membrane/envelope -3.24 0.28 -0.81 2.71 0.039 carboxypeptidase SIGNALING biogenesis II EcolC_0373 b3340 fusA protein chain elongation factor EF- INFORMATION STORAGE AND Translation, ribosomal structure -1.71 -0.48 -0.04 1.20 0.040 G, GTP-binding PROCESSING and biogenesis II EcolC_2526 b1074 flgC flagellar component of cell- CELLULAR PROCESSES AND Cell motility -1.13 -0.03 -1.08 0.02 0.041 proximal portion of basal-body rod SIGNALING II EcolC_0933 b2779 eno enolase METABOLISM Carbohydrate transport and -1.46 -0.53 0.01 0.94 0.043 metabolism II EcolC_0415 b3298 rpsM 30S ribosomal subunit protein S13 INFORMATION STORAGE AND Translation, ribosomal structure -1.90 -0.52 0.02 1.40 0.043 PROCESSING and biogenesis II EcolC_3734 b4330 yjiH predicted inner membrane protein POORLY CHARACTERIZED Function unknown -1.24 -0.98 0.01 0.28 0.045 II EcolC_4233 b3769 ilvM acetolactate synthase II, small POORLY CHARACTERIZED Function unknown -1.58 -0.98 -0.42 0.19 0.048 subunit III EcolC_3904 b4123 dcuB C4-dicarboxylate transporter, POORLY CHARACTERIZED General function prediction only -1.67 1.44 -1.99 1.12 0.001 anaerobic; DcuS co-sensor III EcolC_0584 b3114 tdcE pyruvate formate-lyase 4/2- METABOLISM Energy production and -1.49 1.04 -0.65 1.87 0.001 ketobutyrate formate-lyase conversion IV EcolC_4125 b3893 fdoH formate dehydrogenase-O, Fe-S METABOLISM Energy production and 0.65 -1.13 0.55 -1.23 0.001 subunit conversion IV EcolC_1790 b1842 holE DNA polymerase III, theta subunit - - -0.27 -1.13 0.25 -0.61 0.002

IV EcolC_1329 b2323 fabB 3-oxoacyl-[acyl-carrier-protein] METABOLISM Lipid transport and metabolism -0.16 -1.03 0.73 -0.14 0.002 synthase I IV EcolC_0171 b3544 dppA dipeptide transporter METABOLISM Amino acid transport and 0.43 -1.14 0.15 -1.42 0.003 metabolism IV EcolC_3874 b4138 dcuA C4-dicarboxylate antiporter POORLY CHARACTERIZED General function prediction only -0.66 -1.18 0.27 -0.24 0.004 IV EcolC_1040 b2666 yqaE cyaR sRNA-regulated protein POORLY CHARACTERIZED Function unknown -0.58 -1.53 0.29 -0.65 0.005 IV EcolC_1949 b1682 sufC SufBCD Fe-S cluster assembly CELLULAR PROCESSES AND Posttranslational modification, -0.44 -1.19 0.34 -0.41 0.005 scaffold protein, ATP-binding SIGNALING protein turnover, chaperones protein IV EcolC_1947 b1684 sufA Fe-S cluster assembly protein POORLY CHARACTERIZED Function unknown -0.46 -1.45 0.34 -0.64 0.006 IV EcolC_1212 b2465 tktB transketolase 2, thiamin-binding METABOLISM Carbohydrate transport and -0.76 -1.32 0.25 -0.30 0.010 metabolism IV EcolC_1854 b1778 msrB methionine sulfoxide reductase B CELLULAR PROCESSES AND Posttranslational modification, 0.16 -1.02 0.29 -0.89 0.013 SIGNALING protein turnover, chaperones IV EcolC_0377 b3336 bfr bacterioferritin, iron storage and METABOLISM Inorganic ion transport and -0.42 -1.24 0.34 -0.48 0.013 detoxification protein metabolism IV EcolC_0201 b3516 gadX DNA-binding transcriptional dual INFORMATION STORAGE AND Transcription -0.24 -1.03 1.13 0.34 0.015 regulator PROCESSING IV EcolC_0098 b3610 grxC glutaredoxin 3 CELLULAR PROCESSES AND Posttranslational modification, -0.92 -1.61 0.05 -0.65 0.015 SIGNALING protein turnover, chaperones IV EcolC_0265 b3451 ugpE glycerol-3-phosphate transporter METABOLISM Carbohydrate transport and -0.45 -1.00 -0.49 -1.05 0.026 subunit metabolism IV EcolC_0684 b3012 dkgA 2,5-diketo-D-gluconate reductase POORLY CHARACTERIZED General function prediction only -0.61 -1.09 0.32 -0.17 0.026 A IV EcolC_1948 b1683 sufB component of SufBCD Fe-S CELLULAR PROCESSES AND Posttranslational modification, -0.63 -1.05 0.42 0.01 0.027 cluster assembly scaffold SIGNALING protein turnover, chaperones IV EcolC_1027 b2679 proX glycine betaine transporter subunit METABOLISM Amino acid transport and -0.98 -1.68 0.04 -0.66 0.032 metabolism IV EcolC_0182 b3535 yhjR putative protein - - -0.79 -1.24 0.58 0.13 0.035 IV EcolC_1731 b1905 ftnA ferritin iron storage protein METABOLISM Inorganic ion transport and -0.71 -1.45 -0.19 -0.93 0.041 (cytoplasmic) metabolism V EcolC_3545 b0114 aceE pyruvate dehydrogenase, METABOLISM Energy production and 1.00 -0.35 -0.45 -1.79 0.000 decarboxylase component E1, conversion thiamin-binding V EcolC_0521 b3179 rlmE 23S rRNA U2552 2'-O-ribose INFORMATION STORAGE AND Translation, ribosomal structure 0.21 -0.50 0.10 -0.60 0.000 methyltransferase, SAM- PROCESSING and biogenesis dependent V EcolC_2436 b1189 dadA D-amino acid dehydrogenase METABOLISM Amino acid transport and 0.75 -0.59 0.09 -1.26 0.000 metabolism V EcolC_0982 b2730 hypE carbamoyl dehydratase, CELLULAR PROCESSES AND Posttranslational modification, -0.69 0.43 -0.02 1.09 0.000 hydrogenases 1,2,3 maturation SIGNALING protein turnover, chaperones protein V EcolC_0542 b3156 yhbS predicted acyltransferase with POORLY CHARACTERIZED General function prediction only -0.66 -0.15 0.14 0.65 0.001 acyl-CoA N-acyltransferase domain V EcolC_2834 b0809 glnQ glutamine transporter subunit METABOLISM Amino acid transport and 0.31 -0.15 -0.09 -0.55 0.001 metabolism V EcolC_0700 b2993 hybD maturation protease for METABOLISM Energy production and -0.10 0.79 0.02 0.91 0.001 hydrogenase 2 conversion V EcolC_2037 b1593 ynfK predicted dethiobiotin synthetase METABOLISM Coenzyme transport and -0.59 0.20 0.31 1.09 0.001 metabolism V EcolC_3543 b0116 lpd lipoamide dehydrogenase, E3 METABOLISM Energy production and 0.80 -0.24 -0.27 -1.31 0.001 component is part of three enzyme conversion complexes V EcolC_2241 b1418 cybB cytochrome b561 METABOLISM Energy production and -0.18 -0.72 -0.14 -0.69 0.001 conversion V EcolC_1310 b2343 yfcZ conserved protein, UPF0381 POORLY CHARACTERIZED Function unknown -0.20 0.81 0.01 1.02 0.001 family V EcolC_1884 b1748 astC succinylornithine transaminase, METABOLISM Amino acid transport and 0.72 -0.20 0.00 -0.91 0.001 PLP-dependent metabolism V EcolC_0703 b2990 hybG hydrogenase 2 accessory protein CELLULAR PROCESSES AND Posttranslational modification, 0.11 0.75 0.15 0.78 0.001 SIGNALING protein turnover, chaperones V EcolC_2973 b0683 fur DNA-binding transcriptional dual METABOLISM Inorganic ion transport and 0.41 -0.03 0.05 -0.39 0.001 regulator of siderophore metabolism biosynthesis and transport V EcolC_0613 b3087 ygjR predicted NAD(P)-binding POORLY CHARACTERIZED General function prediction only -0.22 0.51 -0.13 0.61 0.001 dehydrogenase V EcolC_3908 b4119 melA alpha-galactosidase, NAD(P)- METABOLISM Carbohydrate transport and -0.55 0.52 -0.09 0.98 0.001 binding metabolism V EcolC_3856 b4154 frdA fumarate reductase (anaerobic) METABOLISM Energy production and -0.36 0.43 -0.77 0.02 0.001 catalytic and NAD/flavoprotein conversion subunit V EcolC_2261 b1394 paaG 1,2-epoxyphenylacetyl-CoA METABOLISM Lipid transport and metabolism 0.99 -0.04 0.09 -0.94 0.002 isomerase, oxepin-CoA-forming V EcolC_0581 b3117 tdcB catabolic threonine dehydratase, METABOLISM Amino acid transport and 0.08 0.73 0.18 0.83 0.002 PLP-dependent metabolism V EcolC_1343 b2309 hisJ histidine/lysine/arginine/ornithine METABOLISM Amino acid transport and 0.72 -0.22 -0.04 -0.98 0.002 transporter subunit metabolism V EcolC_1988 b1641 slyB outer membrane lipoprotein CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.68 -0.16 0.16 -0.68 0.002 SIGNALING biogenesis V EcolC_3156 b0460 hha modulator of gene expression, with - - -0.02 -0.66 0.28 -0.37 0.002 H-NS V EcolC_0702 b2991 hybF protein involved with the POORLY CHARACTERIZED General function prediction only 0.10 0.59 0.12 0.62 0.002 maturation of hydrogenases 1 and 2 V EcolC_0565 - agaE PTS system, N- METABOLISM Carbohydrate transport and -0.14 0.54 0.43 1.11 0.002 acetylgalactosamine-specific IID metabolism component V EcolC_0459 b3248 yhdE Maf-like protein CELLULAR PROCESSES AND Cell cycle control, cell division, -0.20 -0.41 0.41 0.20 0.002 SIGNALING chromosome partitioning V EcolC_0468 b3238 yhcN conserved protein - - 0.74 -0.46 0.33 -0.86 0.002 V EcolC_1390 b2258 arnF undecaprenyl phosphate-alpha-L- - - 0.91 0.19 0.21 -0.51 0.002 ara4N exporter; flippase ArnEF subunit V EcolC_1142 b2535 csiE stationary phase inducible protein INFORMATION STORAGE AND Transcription 0.68 -0.26 0.36 -0.58 0.002 PROCESSING V EcolC_1769 b1863 ruvC component of RuvABC INFORMATION STORAGE AND Replication, recombination and -0.39 -0.08 -0.06 0.25 0.002 resolvasome, endonuclease PROCESSING repair V EcolC_0496 b3204 ptsN sugar-specific enzyme IIA METABOLISM Carbohydrate transport and -0.84 -0.27 -0.09 0.48 0.002 component of PTS metabolism V EcolC_1982 b1647 ydhF predicted oxidoreductase POORLY CHARACTERIZED General function prediction only -0.66 0.19 -0.19 0.66 0.002 V EcolC_2263 b1392 paaE ring 1,2-phenylacetyl-CoA METABOLISM Energy production and 0.77 -0.51 0.03 -1.25 0.002 epoxidase, NAD(P)H conversion oxidoreductase component V EcolC_3859 b4151 frdD fumarate reductase (anaerobic), METABOLISM Energy production and -0.44 0.42 -0.62 0.24 0.002 membrane anchor subunit conversion V EcolC_4116 b3901 rhaM L-rhamnose mutarotase POORLY CHARACTERIZED Function unknown -0.59 0.38 -0.73 0.23 0.002 V EcolC_0507 b3193 mlaD ABC transporter maintaining OM METABOLISM Secondary metabolites 0.78 -0.72 -0.18 -1.68 0.003 lipid asymmetry, anchored biosynthesis, transport and periplasmic binding protein catabolism V EcolC_2731 b0865 ybjP lipoprotein - - -0.33 -0.82 -0.08 -0.57 0.003 V EcolC_2347 b1279 yciS DUF1049 family inner membrane POORLY CHARACTERIZED Function unknown 0.08 0.48 -0.05 0.34 0.003 protein, function unknown V EcolC_4123 b3894 fdoG formate dehydrogenase-O, large METABOLISM Energy production and 0.11 -0.96 0.57 -0.49 0.003 subunit conversion V EcolC_0821 b2888 uacT uric acid permease METABOLISM Nucleotide transport and -0.55 0.59 0.47 1.62 0.003 metabolism V EcolC_3736 b4328 iadA isoaspartyl dipeptidase METABOLISM Nucleotide transport and -0.93 -0.40 -0.04 0.50 0.003 metabolism V EcolC_1344 b2308 hisQ histidine/lysine/arginine/ornithine METABOLISM Amino acid transport and 0.29 -0.55 -0.11 -0.95 0.003 transporter permease subunit metabolism V EcolC_1356 b2296 ackA acetate kinase A and propionate METABOLISM Energy production and -0.88 0.22 -0.02 1.08 0.003 kinase 2 conversion V EcolC_0838 b2870 ygeW predicted carbamoyltransferase METABOLISM Amino acid transport and -0.87 -0.01 0.71 1.57 0.003 metabolism V EcolC_3735 b4329 yjiG inner membrane protein, SpmB POORLY CHARACTERIZED Function unknown -0.90 -0.46 0.03 0.47 0.003 family V EcolC_1355 b2297 pta phosphate acetyltransferase POORLY CHARACTERIZED General function prediction only -0.53 0.32 -0.17 0.68 0.003 V EcolC_1416 b2235 nrdB ribonucleoside-diphosphate METABOLISM Nucleotide transport and -0.70 -0.36 -0.39 -0.05 0.004 reductase 1, beta subunit, ferritin- metabolism like protein V EcolC_1342 b2310 argT lysine/arginine/ornithine METABOLISM Amino acid transport and 0.71 0.44 0.15 -0.11 0.004 transporter subunit metabolism V EcolC_0931 b2781 mazG nucleoside triphosphate POORLY CHARACTERIZED General function prediction only 0.18 0.44 0.14 0.40 0.004 pyrophosphohydrolase V EcolC_1807 b1826 mgrB regulatory peptide for PhoPQ, - - 0.73 -0.02 0.45 -0.30 0.004 feedback inhibition V EcolC_0600 b3096 mzrA modulator of EnvZ/OmpR regulon INFORMATION STORAGE AND Replication, recombination and -0.09 -0.66 0.90 0.33 0.005 PROCESSING repair V EcolC_4255 b3739 atpI ATP synthase, membrane-bound METABOLISM Energy production and -0.05 -0.67 0.02 -0.60 0.005 accessory factor conversion V EcolC_3655 b4401 arcA DNA-binding response regulator CELLULAR PROCESSES AND Signal transduction mechanisms -0.37 -0.90 0.30 -0.24 0.005 in two-component regulatory SIGNALING system with ArcB or CpxA V EcolC_0701 b2992 hybE hydrogenase 2-specific chaperone - - -0.15 0.39 -0.05 0.49 0.005 V EcolC_1799 b1833 yebS inner membrane protein POORLY CHARACTERIZED Function unknown 0.91 0.15 0.05 -0.71 0.005 V EcolC_2986 b0659 ybeY metal-binding heat shock protein POORLY CHARACTERIZED General function prediction only 0.50 0.11 0.08 -0.31 0.005 required for rRNA maturation V EcolC_2521 b1079 flgH flagellar protein of basal-body CELLULAR PROCESSES AND Cell motility -0.58 0.05 -0.32 0.31 0.005 outer-membrane L ring SIGNALING V EcolC_4053 b3963 fabR DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.45 0.04 0.21 -0.20 0.005 repressor PROCESSING V EcolC_2732 b0864 artP arginine transporter subunit METABOLISM Amino acid transport and -0.32 -0.70 -0.20 -0.58 0.005 metabolism V EcolC_2513 b1088 yceD conserved protein, DUF177 family POORLY CHARACTERIZED General function prediction only -0.92 -0.22 -0.07 0.63 0.005

V EcolC_0582 b3116 tdcC L-threonine/L-serine transporter METABOLISM Amino acid transport and -0.60 0.95 -0.38 1.16 0.005 metabolism V EcolC_3567 b0090 murG N-acetylglucosaminyl transferase CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.24 -0.16 0.04 -0.35 0.005 SIGNALING biogenesis V EcolC_0414 b3299 rpmJ 50S ribosomal subunit protein L36 INFORMATION STORAGE AND Translation, ribosomal structure -0.43 0.06 0.15 0.64 0.005 PROCESSING and biogenesis V EcolC_2719 b0877 ybjX conserved protein POORLY CHARACTERIZED Function unknown 0.53 -0.18 0.29 -0.42 0.005 V EcolC_2385 b1243 oppA oligopeptide transporter subunit METABOLISM Amino acid transport and -0.42 0.41 -0.37 0.46 0.005 metabolism V EcolC_2365 b1262 trpC fused indole-3-glycerolphosphate METABOLISM Amino acid transport and -0.08 -0.68 -0.03 -0.62 0.005 synthetase/N-(5- metabolism phosphoribosyl)anthranilate isomerase V EcolC_0830 b2878 ygfK predicted oxidoreductase, Fe-S METABOLISM Amino acid transport and -0.90 -0.13 0.51 1.28 0.005 subunit metabolism V EcolC_2508 b1093 fabG 3-oxoacyl-[acyl-carrier-protein] METABOLISM Lipid transport and metabolism -0.27 0.26 -0.02 0.51 0.005 reductase V EcolC_1803 b1829 htpX predicted endopeptidase CELLULAR PROCESSES AND Posttranslational modification, 0.85 -0.25 -0.22 -1.32 0.005 SIGNALING protein turnover, chaperones V EcolC_4202 b3805 hemC hydroxymethylbilane synthase METABOLISM Coenzyme transport and -0.37 0.56 -0.06 0.87 0.005 metabolism V EcolC_3562 b0095 ftsZ GTP-binding tubulin-like cell CELLULAR PROCESSES AND Cell cycle control, cell division, -0.04 -0.67 -0.18 -0.80 0.005 division protein SIGNALING chromosome partitioning V EcolC_1867 b1765 ydjA predicted oxidoreductase METABOLISM Energy production and 0.09 -0.79 0.13 -0.75 0.005 conversion V EcolC_2507 b1094 acpP acyl carrier protein (ACP) METABOLISM Lipid transport and metabolism -0.43 0.02 0.11 0.56 0.005 V EcolC_0380 b3333 gspL general secretory pathway CELLULAR PROCESSES AND Intracellular trafficking, -0.01 0.28 0.37 0.66 0.006 component, cryptic SIGNALING secretion, and vesicular transport

V EcolC_1578 b2063 yegH inner membrane protein POORLY CHARACTERIZED General function prediction only 0.29 -0.14 0.25 -0.18 0.006 V EcolC_0968 b2744 surE broad specificity 5'(3')- POORLY CHARACTERIZED General function prediction only 0.50 -0.18 -0.13 -0.81 0.006 nucleotidase and polyphosphatase V EcolC_3310 b0313 betI DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.95 -0.69 -0.14 -1.78 0.006 repressor PROCESSING V EcolC_1792 b1840 yebZ inner membrane protein METABOLISM Inorganic ion transport and 0.90 0.03 -0.01 -0.88 0.006 metabolism V EcolC_3504 b0155 clcA H(+)/Cl(-) exchange transporter METABOLISM Inorganic ion transport and -0.03 -0.55 -0.27 -0.78 0.006 metabolism V EcolC_3541 b0118 acnB bifunctional aconitate hydratase METABOLISM Energy production and 0.15 -0.72 -0.25 -1.12 0.006 2/2-methylisocitrate dehydratase conversion V EcolC_0506 b3194 mlaE ABC transporter maintaining OM METABOLISM Secondary metabolites 0.92 -0.42 -0.02 -1.36 0.006 lipid asymmetry, inner membrane biosynthesis, transport and permease protein catabolism V EcolC_3473 b0187 yaeR predicted lyase METABOLISM Amino acid transport and -0.51 -0.69 -0.14 -0.33 0.006 metabolism V EcolC_2596 b0999 cbpM modulator of CbpA co-chaperone - - -0.59 -0.82 0.21 -0.01 0.007 V EcolC_3037 b0606 ahpF alkyl hydroperoxide reductase, CELLULAR PROCESSES AND Posttranslational modification, -0.22 0.23 -0.30 0.14 0.007 F52a subunit, FAD/NAD(P)- SIGNALING protein turnover, chaperones binding V EcolC_0665 b3032 cpdA 3',5' cAMP phosphodiesterase POORLY CHARACTERIZED General function prediction only 0.29 0.76 -0.04 0.44 0.007 V EcolC_3858 b4152 frdC fumarate reductase (anaerobic), METABOLISM Energy production and -0.29 0.41 -0.76 -0.07 0.007 membrane anchor subunit conversion V EcolC_0172 b3543 dppB dipeptide/heme transporter METABOLISM Amino acid transport and 0.52 -0.24 -0.22 -0.98 0.007 metabolism V EcolC_2847 b0796 ybiH predicted DNA-binding - - 0.91 -0.10 0.67 -0.34 0.007 transcriptional regulator V EcolC_3311 b0312 betB betaine aldehyde dehydrogenase, METABOLISM Energy production and 0.55 -0.65 -0.12 -1.31 0.007 NAD-dependent conversion V EcolC_3676 b4380 yjjI conserved protein METABOLISM Nucleotide transport and -0.83 0.11 -0.15 0.79 0.008 metabolism V EcolC_1853 b1779 gapA glyceraldehyde-3-phosphate METABOLISM Carbohydrate transport and 0.31 0.99 -0.03 0.65 0.008 dehydrogenase A metabolism V EcolC_0566 b3134 agaW - - - -0.44 0.00 0.43 0.88 0.008 V EcolC_4099 b3919 tpiA triosephosphate isomerase METABOLISM Carbohydrate transport and -0.99 -0.01 -0.11 0.88 0.008 metabolism V EcolC_2435 b1190 dadX alanine racemase 2, PLP-binding CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.77 -0.33 0.21 -0.89 0.008 SIGNALING biogenesis V EcolC_0308 b3405 ompR DNA-binding response regulator CELLULAR PROCESSES AND Signal transduction mechanisms 0.26 -0.22 -0.01 -0.48 0.008 in two-component regulatory SIGNALING system with EnvZ V EcolC_3215 b0418 pgpA phosphatidylglycerophosphatase A METABOLISM Lipid transport and metabolism 0.05 0.43 -0.12 0.26 0.008

V EcolC_3122 b0494 tesA multifunctional acyl-CoA METABOLISM Amino acid transport and 0.81 -0.12 0.09 -0.84 0.008 thioesterase I and protease I and metabolism lysophospholipase L1 V EcolC_4126 b3892 fdoI formate dehydrogenase-O, METABOLISM Energy production and 0.26 -0.66 0.48 -0.45 0.009 cytochrome b556 subunit conversion V EcolC_2626 b0970 yccA HflBKC-binding inner membrane POORLY CHARACTERIZED General function prediction only 0.82 -0.16 -0.26 -1.24 0.009 protein, UPF0005 family V EcolC_2509 b1092 fabD malonyl-CoA-[acyl-carrier- METABOLISM Lipid transport and metabolism -0.50 -0.04 -0.21 0.25 0.009 protein] transacylase V EcolC_3544 b0115 aceF pyruvate dehydrogenase, METABOLISM Energy production and 0.37 -0.23 -0.61 -1.21 0.009 dihydrolipoyltransacetylase conversion component E2 V EcolC_0662 b3035 tolC transport channel CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.09 -0.65 -0.13 -0.69 0.009 SIGNALING biogenesis V EcolC_2229 b1431 ydcL lipoprotein - - 0.76 0.06 0.13 -0.57 0.010 V EcolC_2699 b0897 ycaC predicted hydrolase, METABOLISM Secondary metabolites -0.89 -0.26 0.26 0.89 0.010 isochorismatase family biosynthesis, transport and catabolism V EcolC_0651 b3048 yqiI conserved protein - - 0.76 -0.03 0.10 -0.69 0.010 V EcolC_1813 b1819 manZ mannose-specific enzyme IID METABOLISM Carbohydrate transport and 0.11 0.78 -0.06 0.61 0.010 component of PTS metabolism V EcolC_2803 b0839 dacC D-alanyl-D-alanine CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.04 -0.49 0.11 -0.35 0.010 carboxypeptidase (penicillin- SIGNALING biogenesis binding protein 6a) V EcolC_2295 b1329 mppA murein tripeptide (L-ala-gamma- METABOLISM Amino acid transport and 0.47 -0.03 0.05 -0.45 0.010 D-glutamyl-meso-DAP) metabolism transporter subunit V EcolC_3170 b0021 insB1 IS1 transposase B INFORMATION STORAGE AND Replication, recombination and 0.17 0.51 0.41 0.75 0.010 PROCESSING repair V EcolC_2744 b0852 rimK ribosomal protein S6 modification METABOLISM Coenzyme transport and 0.70 -0.37 -0.35 -1.42 0.011 protein metabolism V EcolC_0123 b3590 selB selenocysteinyl-tRNA-specific INFORMATION STORAGE AND Translation, ribosomal structure -0.30 -0.02 0.21 0.49 0.011 translation factor PROCESSING and biogenesis V EcolC_1325 b2327 yfcA inner membrane protein, UPF0721 POORLY CHARACTERIZED General function prediction only 0.20 0.05 -0.03 -0.18 0.011 family V EcolC_3939 b4087 alsA fused D-allose transporter subunits METABOLISM Carbohydrate transport and 0.16 -0.11 -0.13 -0.40 0.011 of ABC superfamily: ATP-binding metabolism components V EcolC_2328 b1297 puuA gamma-Glu-putrescine synthase METABOLISM Amino acid transport and -0.02 -0.20 -0.17 -0.35 0.011 metabolism V EcolC_0492 b3208 mtgA biosynthetic peptidoglycan CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.28 0.00 0.36 0.07 0.011 transglycosylase SIGNALING biogenesis V EcolC_0906 b2806 rlmM 23S rRNA C2498 2'-O-ribose POORLY CHARACTERIZED General function prediction only 0.77 0.49 0.44 0.16 0.011 methyltransferase, SAM- dependent V EcolC_0355 b3357 crp cAMP-activated global CELLULAR PROCESSES AND Signal transduction mechanisms -0.27 -0.65 0.08 -0.29 0.011 transcription factor, mediator of SIGNALING catabolite repression V EcolC_0300 b3413 gntX protein required for the utilization POORLY CHARACTERIZED General function prediction only 0.24 0.55 -0.18 0.13 0.011 of DNA as a carbon source V EcolC_3561 b0096 lpxC UDP-3-O-acyl N- CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.57 -0.15 -0.31 -1.03 0.012 acetylglucosamine deacetylase SIGNALING biogenesis V EcolC_4054 b3962 sthA pyridine nucleotide METABOLISM Energy production and 0.87 -0.21 0.36 -0.73 0.012 transhydrogenase, soluble conversion V EcolC_0472 b3234 degQ serine endoprotease, periplasmic CELLULAR PROCESSES AND Posttranslational modification, 0.30 0.13 0.40 0.23 0.012 SIGNALING protein turnover, chaperones V EcolC_2440 b1185 dsbB oxidoreductase that catalyzes CELLULAR PROCESSES AND Posttranslational modification, -0.32 0.35 0.08 0.75 0.012 reoxidation of DsbA protein SIGNALING protein turnover, chaperones disulfide isomerase I V EcolC_2672 b0924 mukB chromosome condensin MukBEF, CELLULAR PROCESSES AND Cell cycle control, cell division, -0.60 -0.23 -0.45 -0.08 0.012 ATPase and DNA-binding subunit SIGNALING chromosome partitioning

V EcolC_3188 b0444 queC 7-cyano-7-deazaguanine (preQ0) POORLY CHARACTERIZED General function prediction only -0.27 -0.01 -0.14 0.12 0.012 synthase; queuosine biosynthesis V EcolC_0062 b3649 rpoZ RNA polymerase, omega subunit INFORMATION STORAGE AND Transcription -0.42 0.04 0.06 0.53 0.012 PROCESSING V EcolC_1086 b2595 bamD lipoprotein required for OM POORLY CHARACTERIZED General function prediction only -0.36 0.36 0.13 0.84 0.013 biogenesis, in BamABCDE complex V EcolC_1489 b2159 nfo endonuclease IV with intrinsic 3'- INFORMATION STORAGE AND Replication, recombination and 0.42 -0.05 -0.32 -0.79 0.013 5' exonuclease activity PROCESSING repair V EcolC_3185 b4294 insA IS1 repressor TnpA INFORMATION STORAGE AND Replication, recombination and -0.15 0.47 0.30 0.92 0.014 PROCESSING repair V EcolC_2145 b1513 lsrA autoinducer 2 import ATP-binding METABOLISM Carbohydrate transport and 0.74 0.14 0.29 -0.31 0.014 protein metabolism V EcolC_0268 b3448 yhhA conserved protein, DUF2756 - - 0.06 -0.40 0.61 0.15 0.014 family V EcolC_2958 b0698 kdpA potassium translocating ATPase, METABOLISM Inorganic ion transport and 0.20 0.55 0.01 0.36 0.014 subunit A metabolism V EcolC_2390 b1237 hns global DNA-binding POORLY CHARACTERIZED General function prediction only 0.58 -0.26 -0.12 -0.96 0.014 transcriptional dual regulator H- NS V EcolC_3498 b0161 degP serine endoprotease (protease Do), CELLULAR PROCESSES AND Posttranslational modification, 0.51 -0.48 -0.16 -1.15 0.014 membrane-associated SIGNALING protein turnover, chaperones V EcolC_0601 b3095 yqjA general envelope maintenance POORLY CHARACTERIZED Function unknown -0.45 -0.85 1.67 1.27 0.014 protein V EcolC_1498 b2150 mglB methyl-galactoside transporter METABOLISM Carbohydrate transport and 0.76 0.32 -0.32 -0.77 0.015 subunit metabolism V EcolC_0009 b3693 dgoK 2-oxo-3-deoxygalactonate kinase METABOLISM Carbohydrate transport and 0.56 0.32 0.10 -0.15 0.015 metabolism V EcolC_3222 b0411 tsx nucleoside channel, receptor of CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.00 -0.41 -0.38 -0.79 0.015 phage T6 and colicin K SIGNALING biogenesis V EcolC_0726 b2975 glcA glycolate transporter METABOLISM Energy production and 0.42 -0.04 -0.10 -0.56 0.015 conversion V EcolC_0810 b2899 yqfA inner membrane protein, POORLY CHARACTERIZED General function prediction only 0.49 -0.63 0.35 -0.78 0.015 hemolysin III family HylIII V EcolC_0362 b3350 kefB potassium:proton antiporter METABOLISM Inorganic ion transport and 0.47 -0.17 0.53 -0.11 0.015 metabolism V EcolC_3838 b4175 hflC modulator for HflB protease CELLULAR PROCESSES AND Posttranslational modification, 0.39 -0.26 -0.44 -1.10 0.015 specific for phage lambda cII SIGNALING protein turnover, chaperones repressor V EcolC_4127 b3891 fdhE formate dehydrogenase formation CELLULAR PROCESSES AND Posttranslational modification, 0.67 0.23 0.20 -0.24 0.015 protein SIGNALING protein turnover, chaperones V EcolC_3038 b0605 ahpC alkyl hydroperoxide reductase, CELLULAR PROCESSES AND Posttranslational modification, 0.19 0.71 -0.44 0.08 0.016 C22 subunit SIGNALING protein turnover, chaperones V EcolC_0356 b3356 yhfA conserved protein, OsmC family CELLULAR PROCESSES AND Posttranslational modification, 0.20 0.71 0.41 0.92 0.016 SIGNALING protein turnover, chaperones V EcolC_3259 b0369 hemB 5-aminolevulinate dehydratase METABOLISM Coenzyme transport and 0.35 -0.06 -0.30 -0.71 0.016 (porphobilinogen synthase) metabolism V EcolC_3825 b4188 yjfN predicted protein - - 0.66 0.07 0.43 -0.16 0.016 V EcolC_3732 b4332 yjiJ predicted inner membrane protein - - 0.06 0.43 0.25 0.62 0.016 V EcolC_1500 b2148 mglC methyl-galactoside transporter METABOLISM Carbohydrate transport and 0.70 -0.44 -0.59 -1.73 0.017 subunit metabolism V EcolC_3002 b0643 ybeL conserved protein, DUF1451 - - -0.01 0.64 -0.01 0.63 0.017 family V EcolC_4258 b3736 atpF F0 sector of membrane-bound METABOLISM Energy production and -0.09 -0.64 0.14 -0.41 0.017 ATP synthase, subunit b conversion V EcolC_0548 b3150 yraP outer membrane lipoprotein POORLY CHARACTERIZED General function prediction only -0.22 0.11 -0.12 0.21 0.017 V EcolC_0477 b3229 sspA stringent starvation protein A, CELLULAR PROCESSES AND Posttranslational modification, 0.27 0.67 0.04 0.45 0.017 phage P1 late gene activator, SIGNALING protein turnover, chaperones RNAP-associated acid-resistance protein, inactive glutathione S- transferase homolog V EcolC_1279 b2390 ypeC conserved protein - - 0.77 0.03 0.60 -0.14 0.017 V EcolC_1175 b2501 ppk polyphosphate kinase, component METABOLISM Inorganic ion transport and -0.42 0.00 -0.07 0.34 0.017 of RNA degradosome metabolism V EcolC_0061 b3650 spoT bifunctional (p)ppGpp synthetase CELLULAR PROCESSES AND Signal transduction mechanisms 0.34 0.62 0.24 0.52 0.017 II/ guanosine-3',5'-bis SIGNALING pyrophosphate 3'- pyrophosphohydrolase V EcolC_2692 b0904 focA formate channel METABOLISM Inorganic ion transport and 0.63 -0.13 0.04 -0.73 0.017 metabolism V EcolC_3309 b0314 betT choline transporter of high affinity CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.01 -0.49 -0.22 -0.70 0.017 SIGNALING biogenesis V EcolC_1862 b1770 ydjF predicted DNA-binding INFORMATION STORAGE AND Transcription 0.71 0.26 0.01 -0.43 0.018 transcriptional regulator PROCESSING V EcolC_2046 b1584 speG spermidine N1-acetyltransferase INFORMATION STORAGE AND Translation, ribosomal structure 0.67 0.28 0.17 -0.22 0.018 PROCESSING and biogenesis V EcolC_4045 b3339 tufA protein chain elongation factor EF- INFORMATION STORAGE AND Translation, ribosomal structure 0.43 0.74 -0.18 0.13 0.018 Tu (duplicate of tufB) PROCESSING and biogenesis V EcolC_0802 b2907 ubiH 2-octaprenyl-6-methoxyphenol METABOLISM Coenzyme transport and -0.03 0.19 -0.12 0.11 0.018 hydroxylase, FAD/NAD(P)- metabolism binding V EcolC_3194 b0438 clpX ATPase and specificity subunit of CELLULAR PROCESSES AND Posttranslational modification, -0.06 -0.34 -0.11 -0.39 0.018 ClpX-ClpP ATP-dependent serine SIGNALING protein turnover, chaperones protease V EcolC_3245 b0387 yaiI conserved protein, UPF0178 POORLY CHARACTERIZED Function unknown 0.16 0.44 -0.28 0.00 0.018 family, downregulated by beryllium V EcolC_3214 b0419 yajO 2-carboxybenzaldehyde reductase METABOLISM Energy production and -0.51 -0.05 -0.25 0.21 0.018 conversion V EcolC_0080 - waaG glucosyltransferase I CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.26 0.14 -0.05 0.34 0.018 SIGNALING biogenesis

V EcolC_0783 b2927 epd D-erythrose 4-phosphate METABOLISM Carbohydrate transport and -0.41 -0.11 0.08 0.38 0.018 dehydrogenase metabolism V EcolC_0160 b3556 cspA RNA chaperone and anti- INFORMATION STORAGE AND Transcription 0.61 0.05 0.08 -0.48 0.018 terminator, cold-inducible PROCESSING V EcolC_1801 b1831 proQ RNA chaperone, probable CELLULAR PROCESSES AND Signal transduction mechanisms 0.46 -0.15 -0.27 -0.88 0.019 regulator of ProP translation SIGNALING V EcolC_3998 b4031 xylE D-xylose transporter - - 0.05 0.41 -0.15 0.22 0.019 V EcolC_1105 b2572 rseA anti-sigma factor CELLULAR PROCESSES AND Signal transduction mechanisms 0.09 -0.78 1.15 0.29 0.019 SIGNALING V EcolC_0543 b3155 yhbQ conserved protein, GIY-YIG INFORMATION STORAGE AND Replication, recombination and -0.44 0.35 0.29 1.08 0.019 nuclease superfamily PROCESSING repair V EcolC_0809 b2900 yqfB conserved protein, UPF0267 POORLY CHARACTERIZED Function unknown 0.40 0.02 0.10 -0.28 0.020 family V EcolC_2493 b1108 ycfP conserved protein POORLY CHARACTERIZED General function prediction only -0.88 -0.40 0.11 0.58 0.020 V EcolC_2472 b1131 purB adenylosuccinate lyase METABOLISM Nucleotide transport and -0.25 -0.01 -0.40 -0.16 0.020 metabolism V EcolC_1763 b1869 yecN inner membrane protein, MAPEG POORLY CHARACTERIZED General function prediction only 0.16 0.65 0.01 0.50 0.020 family V EcolC_4069 b3946 fsaB fructose-6-phosphate aldolase 2 METABOLISM Carbohydrate transport and 0.07 0.66 -0.04 0.56 0.020 metabolism V EcolC_1992 b1637 tyrS tyrosyl-tRNA synthetase INFORMATION STORAGE AND Translation, ribosomal structure 0.03 0.36 -0.24 0.09 0.020 PROCESSING and biogenesis V EcolC_4197 b3810 yigA conserved protein, DUF484 family POORLY CHARACTERIZED Function unknown 0.15 0.54 0.27 0.67 0.020

V EcolC_4198 b3809 dapF diaminopimelate epimerase METABOLISM Amino acid transport and -0.02 0.26 0.12 0.40 0.020 metabolism V EcolC_0647 b3052 hldE fused heptose 7-phosphate CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.50 -0.25 -0.01 0.24 0.020 kinase/heptose 1-phosphate SIGNALING biogenesis adenyltransferase V EcolC_3187 b0445 ybaE predicted transporter subunit: POORLY CHARACTERIZED General function prediction only 0.12 -0.34 0.00 -0.45 0.020 periplasmic-binding component of ABC superfamily V EcolC_3096 b0526 cysS cysteinyl-tRNA synthetase INFORMATION STORAGE AND Translation, ribosomal structure -0.41 0.02 -0.18 0.25 0.021 PROCESSING and biogenesis V EcolC_1913 b1719 thrS threonyl-tRNA synthetase INFORMATION STORAGE AND Translation, ribosomal structure -0.44 0.36 -0.06 0.75 0.021 PROCESSING and biogenesis V EcolC_0836 b2872 ygeY predicted peptidase METABOLISM Amino acid transport and -0.82 -0.05 1.28 2.06 0.021 metabolism V EcolC_3839 b4174 hflK modulator for HflB protease CELLULAR PROCESSES AND Posttranslational modification, 0.47 0.09 -0.34 -0.72 0.021 specific for phage lambda cII SIGNALING protein turnover, chaperones repressor V EcolC_1791 b1841 yobA conserved protein POORLY CHARACTERIZED General function prediction only 0.31 -0.12 0.08 -0.35 0.021 V EcolC_2987 b0658 ybeX predicteed ion transport METABOLISM Inorganic ion transport and 0.39 -0.01 0.16 -0.24 0.021 metabolism V EcolC_2512 b1089 rpmF 50S ribosomal subunit protein L32 INFORMATION STORAGE AND Translation, ribosomal structure -0.41 0.16 0.00 0.57 0.021 PROCESSING and biogenesis V EcolC_0885 b2830 rppH RNA pyrophosphohydrolase INFORMATION STORAGE AND Replication, recombination and 0.58 -0.30 -0.01 -0.89 0.022 PROCESSING repair V EcolC_1786 b1846 yebE inner membrane protein, DUF533 POORLY CHARACTERIZED Function unknown 0.56 0.11 0.26 -0.19 0.022 family V EcolC_2252 b1406 ydbC predicted oxidoreductase, METABOLISM Energy production and 0.06 0.70 -0.19 0.45 0.022 NAD(P)-binding conversion V EcolC_3065 b0581 ybdK weak gamma-glutamyl:cysteine POORLY CHARACTERIZED Function unknown -0.27 -0.69 0.16 -0.26 0.022 ligase V EcolC_1475 b2172 yeiQ predicted D-mannonate METABOLISM Carbohydrate transport and -0.27 -0.70 0.51 0.08 0.022 oxidoreductase, NAD-dependent metabolism V EcolC_1467 b2180 yejF microcin C transporter, ATP- POORLY CHARACTERIZED General function prediction only 0.48 0.77 0.22 0.51 0.022 binding subunit; ABC family V EcolC_3141 b0475 hemH ferrochelatase METABOLISM Coenzyme transport and -0.24 -0.70 0.11 -0.36 0.022 metabolism V EcolC_3621 b0034 caiF DNA-binding transcriptional - - -0.70 0.17 -0.10 0.77 0.022 activator V EcolC_2210 b1449 curA curcumin/dihydrocurcumin POORLY CHARACTERIZED General function prediction only 0.03 0.63 -0.32 0.27 0.022 reductase, NADPH-dependent V EcolC_2563 b1036 ycdZ DUF1097 family inner membrane - - 0.46 0.74 0.05 0.33 0.022 protein V EcolC_2527 b1073 flgB flagellar component of cell- CELLULAR PROCESSES AND Cell motility -0.58 0.01 -0.50 0.08 0.023 proximal portion of basal-body rod SIGNALING V EcolC_1019 b2688 gshA glutamate-cysteine ligase METABOLISM Coenzyme transport and -0.86 -0.48 -0.29 0.09 0.023 metabolism V EcolC_2705 b0891 lolA lipoprotein chaperone CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.74 -0.35 -0.16 0.23 0.023 SIGNALING biogenesis V EcolC_2473 b1130 phoP DNA-binding response regulator CELLULAR PROCESSES AND Signal transduction mechanisms 0.92 0.14 0.15 -0.62 0.023 in two-component regulatory SIGNALING system with PhoQ V EcolC_2725 b0871 poxB pyruvate dehydrogenase (pyruvate METABOLISM Amino acid transport and 0.18 -0.06 0.08 -0.16 0.023 oxidase), thiamin-dependent, metabolism FAD-binding V EcolC_0625 b3075 ebgR DNA-binding transcriptional INFORMATION STORAGE AND Transcription -0.05 0.16 0.23 0.44 0.023 repressor PROCESSING V EcolC_1819 b1814 sdaA L-serine deaminase I METABOLISM Amino acid transport and 0.10 0.53 0.03 0.46 0.023 metabolism V EcolC_4005 b4025 pgi glucosephosphate isomerase METABOLISM Carbohydrate transport and -0.13 -0.45 -0.06 -0.38 0.023 metabolism V EcolC_0796 b2914 rpiA ribose 5-phosphate isomerase, METABOLISM Carbohydrate transport and 0.08 0.56 -0.01 0.47 0.023 constitutive metabolism V EcolC_2832 b0811 glnH glutamine transporter subunit METABOLISM Amino acid transport and 0.14 -0.67 -0.64 -1.45 0.024 metabolism V EcolC_2026 b1604 ydgH predicted protein - - -0.42 0.03 -0.23 0.22 0.024 V EcolC_1090 b2587 kgtP alpha-ketoglutarate transporter METABOLISM Carbohydrate transport and 0.46 0.17 0.15 -0.14 0.025 metabolism V EcolC_2730 b0866 ybjQ conserved protein, UPF0145 POORLY CHARACTERIZED Function unknown 0.09 -0.27 0.10 -0.25 0.025 family V EcolC_2852 b0791 ybhQ inner membrane protein - - 0.15 -0.10 0.25 0.00 0.025 V EcolC_1299 b2370 evgS hybrid sensory histidine kinase in CELLULAR PROCESSES AND Signal transduction mechanisms 0.95 0.10 0.43 -0.42 0.025 two-component regulatory system SIGNALING with EvgA V EcolC_3144 b0472 recR gap repair protein INFORMATION STORAGE AND Replication, recombination and -0.12 0.14 -0.09 0.17 0.025 PROCESSING repair V EcolC_1951 b1680 sufS cysteine desulfurase, stimulated by METABOLISM Amino acid transport and -0.31 -0.67 0.30 -0.07 0.025 SufE; selenocysteine lyase, PLP- metabolism dependent V EcolC_3854 b4156 yjeM predicted transporter METABOLISM Amino acid transport and 0.71 0.40 0.07 -0.24 0.026 metabolism V EcolC_0091 b3617 kbl glycine C-acetyltransferase METABOLISM Coenzyme transport and -0.03 -0.38 -0.37 -0.72 0.026 metabolism V EcolC_2264 b1391 paaD ring 1,2-phenylacetyl-CoA POORLY CHARACTERIZED General function prediction only 0.98 -0.03 0.13 -0.88 0.026 epoxidase subunit V EcolC_2187 b1469 narU nitrate/nitrite transporter METABOLISM Inorganic ion transport and -0.09 -0.73 -0.10 -0.74 0.026 metabolism V EcolC_1415 b2236 yfaE ferredoxin involved with METABOLISM Energy production and 0.86 0.35 -0.04 -0.56 0.026 ribonucleotide reductase diferric- conversion tyrosyl radical (Y*) cofactor maintenance V EcolC_3948 b4079 fdhF formate dehydrogenase-H, POORLY CHARACTERIZED General function prediction only -0.58 0.08 0.09 0.75 0.026 selenopolypeptide subunit V EcolC_3252 b0380 yaiZ predicted inner membrane protein, - - 0.26 -0.02 -0.07 -0.35 0.026 DUF2754 family V EcolC_2182 b1475 fdnH formate dehydrogenase-N, Fe-S METABOLISM Energy production and 0.30 -0.16 0.33 -0.13 0.026 (beta) subunit, nitrate-inducible conversion V EcolC_0536 b3162 deaD ATP-dependent RNA helicase INFORMATION STORAGE AND Replication, recombination and -0.67 -0.07 0.16 0.76 0.026 PROCESSING repair V EcolC_1161 b2516 rodZ cytoskeletal protein required for POORLY CHARACTERIZED Function unknown 0.17 -0.30 0.25 -0.22 0.026 MreB assembly V EcolC_0538 b3160 yhbW predicted enzyme METABOLISM Energy production and 1.00 -0.08 0.20 -0.88 0.026 conversion V EcolC_0186 b3531 bcsZ endo-1,4-D-glucanase METABOLISM Carbohydrate transport and -0.15 -0.62 0.13 -0.34 0.026 metabolism V EcolC_2267 b1388 paaA ring 1,2-phenylacetyl-CoA POORLY CHARACTERIZED Function unknown 0.76 -0.01 0.02 -0.75 0.026 epoxidase subunit V EcolC_1066 b2618 ratB conserved protein, UPF0125 POORLY CHARACTERIZED Function unknown 0.37 -0.12 -0.16 -0.66 0.027 family V EcolC_0229 b3486 rbbA fused ribosome-associated CELLULAR PROCESSES AND Defense mechanisms 0.18 -0.44 0.07 -0.55 0.027 ATPase: ATP-binding SIGNALING protein/ATP-binding protein/predicted membrane protein V EcolC_1151 b2526 hscA DnaK-like molecular chaperone CELLULAR PROCESSES AND Posttranslational modification, 0.46 0.19 -0.10 -0.37 0.027 specific for IscU SIGNALING protein turnover, chaperones V EcolC_1386 b2262 menB dihydroxynaphthoic acid METABOLISM Coenzyme transport and -0.28 0.32 -0.18 0.42 0.027 synthetase metabolism V EcolC_3757 b4255 rraB protein inhibitor of RNase E POORLY CHARACTERIZED Function unknown -0.30 0.14 0.12 0.55 0.027 V EcolC_1205 b2472 dapE N-succinyl-diaminopimelate METABOLISM Amino acid transport and 0.62 0.10 0.11 -0.41 0.027 deacylase metabolism V EcolC_3548 b0111 ampE predicted inner membrane protein CELLULAR PROCESSES AND Defense mechanisms -0.43 -0.23 -0.39 -0.18 0.027 SIGNALING V EcolC_0818 b2891 prfB peptide chain release factor RF-2 INFORMATION STORAGE AND Translation, ribosomal structure -0.48 -0.08 -0.33 0.07 0.027 PROCESSING and biogenesis V EcolC_2693 b0903 pflB pyruvate formate lyase I METABOLISM Energy production and -0.32 0.46 -0.11 0.67 0.027 conversion V EcolC_4015 b4015 aceA isocitrate lyase METABOLISM Energy production and 0.45 0.18 0.40 0.14 0.027 conversion V EcolC_0449 b3257 yhdT conserved inner membrane protein POORLY CHARACTERIZED Function unknown 0.04 0.28 0.31 0.55 0.027

V EcolC_1994 b1635 gstA glutathionine S-transferase CELLULAR PROCESSES AND Posttranslational modification, 0.61 0.26 0.00 -0.35 0.028 SIGNALING protein turnover, chaperones V EcolC_1908 b1724 ydiZ predicted protein - - -0.36 -0.17 0.09 0.28 0.028 V EcolC_0122 b3591 selA selenocysteine synthase METABOLISM Amino acid transport and -0.42 0.01 0.17 0.59 0.028 metabolism V EcolC_3399 b0221 fadE acyl coenzyme A dehydrogenase METABOLISM Lipid transport and metabolism 0.61 -0.26 -0.21 -1.08 0.028 V EcolC_3136 b0480 ushA bifunctional UDP-sugar METABOLISM Nucleotide transport and -0.38 -0.06 -0.33 -0.01 0.029 hydrolase/5'-nucleotidase metabolism V EcolC_2716 b0880 cspD inhibitor of DNA replication, cold INFORMATION STORAGE AND Transcription 0.07 -0.84 0.22 -0.68 0.029 shock protein homolog PROCESSING V EcolC_0327 b3386 rpe D-ribulose-5-phosphate 3- METABOLISM Carbohydrate transport and -0.77 -0.31 -0.22 0.24 0.029 epimerase metabolism V EcolC_1929 b1702 ppsA phosphoenolpyruvate synthase METABOLISM Carbohydrate transport and -0.28 -0.64 -0.56 -0.92 0.029 metabolism V EcolC_0530 b3168 infB fused protein chain initiation INFORMATION STORAGE AND Translation, ribosomal structure -0.74 -0.26 0.02 0.49 0.029 factor 2, IF2: membrane PROCESSING and biogenesis protein/conserved protein V EcolC_0661 b3037 ygiB DUF1190 family protein POORLY CHARACTERIZED Function unknown 0.70 0.06 -0.26 -0.90 0.030 V EcolC_3480 b0180 fabZ (3R)-hydroxymyristol acyl carrier METABOLISM Lipid transport and metabolism -0.44 -0.23 -0.13 0.08 0.030 protein dehydratase V EcolC_2516 b1084 rne fused ribonucleaseE: INFORMATION STORAGE AND Translation, ribosomal structure 1.00 -0.26 -0.12 -1.38 0.030 endoribonuclease/RNA-binding PROCESSING and biogenesis protein/RNA degradosome binding protein V EcolC_3112 b0511 ybbW predicted allantoin transporter METABOLISM Nucleotide transport and 0.93 0.06 -0.03 -0.90 0.030 metabolism V EcolC_3158 b0458 ylaC inner membrane protein, - - -0.39 -0.69 -0.53 -0.84 0.030 DUF1449 family V EcolC_0522 b3178 ftsH protease, ATP-dependent zinc- CELLULAR PROCESSES AND Posttranslational modification, 0.09 -0.48 -0.12 -0.69 0.030 metallo SIGNALING protein turnover, chaperones V EcolC_1909 b1723 pfkB 6-phosphofructokinase II METABOLISM Carbohydrate transport and 0.04 -0.33 0.22 -0.15 0.030 metabolism V EcolC_0465 b3241 aaeA p-hydroxybenzoic acid efflux CELLULAR PROCESSES AND Defense mechanisms -0.36 -0.08 0.02 0.30 0.030 system component SIGNALING V EcolC_0036 b3663 yicN conserved protein - - 0.17 0.34 0.41 0.58 0.030 V EcolC_0840 b2868 xdhC xanthine dehydrogenase, Fe-S METABOLISM Energy production and 0.34 0.68 0.46 0.80 0.030 binding subunit conversion V EcolC_2119 b1539 ydfG malonic semialdehyde reductase, POORLY CHARACTERIZED General function prediction only -0.26 0.21 -0.04 0.43 0.031 NADPH-dependent; L-allo- threonine dehydrogenase, NAD(P)-dependent; also oxidizes L-serine, D-serine, D-threonine and 3-hydroxyisobutyrate V EcolC_4160 b3850 hemG protoporphyrin oxidase, METABOLISM Energy production and -0.28 -0.05 0.20 0.43 0.031 flavoprotein conversion V EcolC_0220 b3496 dtpB dipeptide and tripeptide permease METABOLISM Amino acid transport and 0.03 -0.36 0.10 -0.29 0.031 B metabolism V EcolC_1281 b2388 glk glucokinase METABOLISM Carbohydrate transport and 0.06 0.49 -0.05 0.38 0.031 metabolism V EcolC_3894 b4133 cadC DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.22 0.60 0.39 0.77 0.032 activator PROCESSING V EcolC_3817 b4196 ulaD 3-keto-L-gulonate 6-phosphate METABOLISM Carbohydrate transport and 0.41 0.70 0.21 0.51 0.032 decarboxylase metabolism V EcolC_2312 b1313 ycjQ predicted oxidoreductase, Zn- METABOLISM Amino acid transport and 0.15 -0.12 -0.18 -0.45 0.032 dependent and NAD(P)-binding metabolism V EcolC_0979 b2733 mutS methyl-directed mismatch repair INFORMATION STORAGE AND Replication, recombination and 0.51 0.25 0.11 -0.15 0.032 protein PROCESSING repair V EcolC_1814 b1818 manY mannose-specific enzyme IIC METABOLISM Carbohydrate transport and -0.07 0.73 0.06 0.87 0.032 component of PTS metabolism V EcolC_2538 b1062 pyrC dihydro-orotase METABOLISM Nucleotide transport and -0.01 -0.33 -0.03 -0.34 0.033 metabolism V EcolC_1808 b1825 yebO predicted inner membrane protein - - 0.89 -0.11 0.47 -0.53 0.033 V EcolC_2941 b0714 nei endonuclease VIII/ 5- INFORMATION STORAGE AND Replication, recombination and -0.01 0.11 -0.06 0.06 0.033 formyluracil/5- PROCESSING repair hydroxymethyluracil DNA glycosylase V EcolC_4171 b3838 tatB TatABCE protein translocation CELLULAR PROCESSES AND Intracellular trafficking, -0.45 -0.03 -0.06 0.36 0.033 system subunit SIGNALING secretion, and vesicular transport V EcolC_1432 b2218 rcsC hybrid sensory kinase in two- CELLULAR PROCESSES AND Signal transduction mechanisms 0.54 0.16 0.06 -0.32 0.033 component regulatory system with SIGNALING RcsB and YojN V EcolC_1114 b2563 acpS holo-[acyl-carrier-protein] METABOLISM Lipid transport and metabolism -0.88 -0.54 0.00 0.34 0.034 synthase 1 V EcolC_4246 b3748 rbsD predicted cytoplasmic sugar- METABOLISM Carbohydrate transport and 0.95 0.13 0.21 -0.61 0.034 binding protein metabolism V EcolC_3094 b0528 ybcJ ribosome-associated protein; POORLY CHARACTERIZED Function unknown -0.25 0.08 -0.06 0.27 0.034 predicted RNA-binding protein V EcolC_1918 b1713 pheT phenylalanine tRNA synthetase, INFORMATION STORAGE AND Translation, ribosomal structure -0.26 0.08 -0.16 0.17 0.034 beta subunit PROCESSING and biogenesis V EcolC_3771 b4240 treB fused trehalose(maltose)-specific METABOLISM Carbohydrate transport and 0.85 -0.05 0.06 -0.85 0.035 PTS enzyme: IIB component/IIC metabolism component V EcolC_2017 b1613 manA mannose-6-phosphate isomerase METABOLISM Carbohydrate transport and -0.02 0.41 -0.06 0.37 0.036 metabolism V EcolC_2381 b1247 oppF oligopeptide transporter subunit METABOLISM Amino acid transport and 0.15 0.73 0.16 0.75 0.036 metabolism V EcolC_3836 b4177 purA adenylosuccinate synthetase METABOLISM Nucleotide transport and 0.07 0.76 0.07 0.76 0.036 metabolism V EcolC_0633 b3066 dnaG DNA primase INFORMATION STORAGE AND Replication, recombination and 0.17 -0.09 0.52 0.26 0.036 PROCESSING repair V EcolC_2260 b1395 paaH 3-hydroxyadipyl-CoA METABOLISM Lipid transport and metabolism 0.47 0.01 -0.01 -0.47 0.036 dehydrogenase, NAD+-dependent V EcolC_1206 b2471 yffB predicted reductase, function METABOLISM Inorganic ion transport and 0.48 0.03 0.04 -0.41 0.036 unknown, ArsC family; low metabolism abundance protein V EcolC_1096 b2581 yfiF predicted methyltransferase INFORMATION STORAGE Translation, ribosomal -0.62 0.18 -0.15 0.65 0.036 AND PROCESSING structure and biogenesis V EcolC_1809 b1823 cspC stress protein, member of the INFORMATION STORAGE AND Transcription 0.67 0.23 -0.04 -0.47 0.036 CspA-family PROCESSING V EcolC_3127 b0489 qmcA multicopy suppressor of ftsH htpX CELLULAR PROCESSES AND Posttranslational modification, -0.03 -0.37 -0.10 -0.45 0.036 double mutant; membrane- SIGNALING protein turnover, chaperones anchored predicted protease with C-terminal cytoplasmic PHB domain V EcolC_3555 b0103 coaE dephospho-CoA kinase METABOLISM Coenzyme transport and 0.04 -0.19 -0.15 -0.38 0.036 metabolism V EcolC_3873 b4139 aspA aspartate ammonia-lyase METABOLISM Amino acid transport and 0.51 0.01 0.14 -0.36 0.036 metabolism V EcolC_4174 b3834 yigP conserved protein, SCP2 family POORLY CHARACTERIZED Function unknown 0.64 0.21 0.08 -0.35 0.036 V EcolC_2044 b1586 ynfD predicted protein - - -0.34 -0.64 0.21 -0.09 0.036 V EcolC_0587 b3110 yhaO predicted transporter METABOLISM Amino acid transport and -1.00 -0.34 -0.38 0.28 0.036 metabolism V EcolC_1514 b2133 dld D-lactate dehydrogenase, FAD- METABOLISM Energy production and -0.08 0.32 -0.44 -0.05 0.037 binding, NADH independent conversion V EcolC_2676 b0920 ycbC conserved protein, DUF218 POORLY CHARACTERIZED Function unknown -0.10 0.36 0.45 0.90 0.037 superfamily V EcolC_2008 b1622 malY bifunctional beta-cystathionase, METABOLISM Amino acid transport and -0.08 0.28 -0.09 0.27 0.037 PLP-dependent/ regulator of metabolism maltose regulon V EcolC_0562 b3136 agaS tagatose-6-phosphate CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.82 -0.62 0.09 0.29 0.037 ketose/aldose isomerase SIGNALING biogenesis V EcolC_0255 b3461 rpoH RNA polymerase, sigma 32 (sigma INFORMATION STORAGE AND Transcription -0.43 -0.08 0.17 0.52 0.037 H) factor PROCESSING V EcolC_1720 b1919 dcyD D-cysteine desulfhydrase, PLP- METABOLISM Amino acid transport and 0.34 0.71 0.19 0.57 0.038 dependent metabolism V EcolC_0887 b2828 lgt phosphatidylglycerol- CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.49 -0.36 -0.20 -0.08 0.038 prolipoprotein diacylglyceryl SIGNALING biogenesis transferase V EcolC_3081 - - hypothetical protein - - -0.19 0.09 0.03 0.31 0.038 V EcolC_1152 b2525 fdx [2Fe-2S] ferredoxin METABOLISM Energy production and 0.37 0.08 -0.02 -0.31 0.038 conversion V EcolC_1312 b2341 fadJ fused enoyl-CoA hydratase and METABOLISM Lipid transport and metabolism 0.49 -0.07 0.17 -0.40 0.038 epimerase and isomerase/3- hydroxyacyl-CoA dehydrogenase V EcolC_2826 b0817 mntR DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.29 -0.05 -0.10 -0.43 0.038 regulator of mntH PROCESSING V EcolC_1968 b1661 cfa cyclopropane fatty acyl CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.25 0.00 0.44 0.69 0.039 phospholipid synthase SIGNALING biogenesis (unsaturated-phospholipid methyltransferase) V EcolC_3503 b0156 erpA iron-sulfur cluster insertion protein POORLY CHARACTERIZED Function unknown 0.17 -0.13 -0.14 -0.44 0.039 V EcolC_0631 b3068 mug G/U mismatch-specific DNA INFORMATION STORAGE AND Replication, recombination and 0.43 -0.13 0.11 -0.45 0.040 glycosylase; xanthine DNA PROCESSING repair glycosylase V EcolC_2114 b1375 ynaE cold shock protein, function - - -0.18 -0.58 0.58 0.19 0.040 unknown, Rac prophage V EcolC_2387 b1241 adhE fused acetaldehyde-CoA METABOLISM Energy production and -0.53 -0.03 0.22 0.72 0.040 dehydrogenase/iron-dependent conversion alcohol dehydrogenase/pyruvate- formate lyase deactivase V EcolC_2060 b1568 ydfX - - - 0.50 0.20 0.27 -0.03 0.040 V EcolC_0930 b2782 mazF mRNA interferase toxin, antitoxin CELLULAR PROCESSES AND Signal transduction mechanisms 0.02 0.48 -0.08 0.37 0.040 is MazE SIGNALING V EcolC_1915 b1717 rpmI 50S ribosomal subunit protein L35 INFORMATION STORAGE AND Translation, ribosomal structure -0.44 0.08 0.00 0.53 0.040 PROCESSING and biogenesis V EcolC_3074 b0572 cusC copper/silver efflux system, outer CELLULAR PROCESSES AND Cell wall/membrane/envelope -0.19 -0.36 -0.26 -0.42 0.041 membrane component SIGNALING biogenesis V EcolC_2123 b1535 ydeH diguanylate cyclase, required for CELLULAR PROCESSES AND Signal transduction mechanisms 0.98 0.44 0.21 -0.33 0.041 pgaD induction SIGNALING V EcolC_4178 b3830 ysgA predicted hydrolase METABOLISM Secondary metabolites 0.65 -0.10 0.14 -0.61 0.042 biosynthesis, transport and catabolism V EcolC_2649 b0947 ycbX predicted 2Fe-2S cluster- POORLY CHARACTERIZED General function prediction only -0.07 0.22 0.01 0.30 0.042 containing protein; 6-N- hydroxylaminopurine resistance protein V EcolC_1082 b2601 aroF 3-deoxy-D-arabino-heptulosonate- METABOLISM Amino acid transport and 0.25 -0.01 0.20 -0.06 0.042 7-phosphate synthase, tyrosine- metabolism repressible V EcolC_2458 b1168 ycgG predicted membrane-anchored CELLULAR PROCESSES AND Signal transduction mechanisms -0.28 -0.19 -0.66 -0.57 0.043 cyclic-di-GMP phosphodiesterase SIGNALING V EcolC_3342 b0239 frsA fermentation-respiration switch METABOLISM Secondary metabolites 0.01 0.42 -0.19 0.22 0.043 protein; PTS Enzyme IIA(Glc)- biosynthesis, transport and binding protein; pNP-butyrate catabolism esterase activity V EcolC_0754 b2960 trmI tRNA m(7)G46 methyltransferase, POORLY CHARACTERIZED General function prediction only -0.86 -0.63 0.08 0.31 0.043 SAM-dependent

V EcolC_0310 b3403 pck phosphoenolpyruvate METABOLISM Energy production and -0.60 0.04 0.00 0.64 0.043 carboxykinase conversion V EcolC_0908 b2804 fucU L-fucose mutarotase METABOLISM Carbohydrate transport and 0.34 0.60 0.01 0.27 0.044 metabolism V EcolC_1363 b2289 lrhA DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.82 0.22 -0.08 -0.68 0.044 repressor of flagellar, motility and PROCESSING chemotaxis genes V EcolC_1745 b1887 cheW purine-binding chemotaxis protein CELLULAR PROCESSES AND Cell motility 0.15 0.32 0.29 0.46 0.045 SIGNALING V EcolC_0141 b3573 ysaA predicted hydrogenase, 4Fe-4S METABOLISM Energy production and -0.76 -0.19 0.02 0.59 0.045 ferredoxin-type component conversion V EcolC_2362 b1266 yciV conserved protein POORLY CHARACTERIZED General function prediction only 0.24 -0.02 -0.02 -0.27 0.046 V EcolC_2979 b0677 nagA N-acetylglucosamine-6-phosphate METABOLISM Carbohydrate transport and -0.25 -0.50 -0.22 -0.47 0.046 deacetylase metabolism V EcolC_2729 b0867 amiD 1,6-anhydro-N-acetylmuramyl-L- CELLULAR PROCESSES AND Defense mechanisms 0.09 -0.10 -0.02 -0.22 0.046 alanine amidase, Zn-dependent; SIGNALING OM lipoprotein V EcolC_1382 b2266 elaB ribosome-binding protein, POORLY CHARACTERIZED Function unknown -0.03 -0.32 0.27 -0.02 0.046 probably membrane-anchored, function unknown V EcolC_1537 b2110 yehC predicted periplasmic pilin CELLULAR PROCESSES AND Cell motility 0.05 -0.10 0.28 0.13 0.046 chaperone SIGNALING V EcolC_0692 b3002 yqhA predicted inner membrane protein, POORLY CHARACTERIZED Function unknown 0.10 0.45 0.27 0.62 0.046 UPF0114 family V EcolC_0844 b2863 ygeQ - - - -0.12 -0.78 -0.22 -0.88 0.047 V EcolC_2621 b0975 hyaD hydrogenase 1 maturation protease METABOLISM Energy production and -0.01 -0.76 -0.60 -1.35 0.047 conversion V EcolC_1828 b1805 fadD acyl-CoA synthetase (long-chain- METABOLISM Lipid transport and metabolism 0.47 -0.05 0.08 -0.44 0.047 fatty-acid--CoA ligase) V EcolC_2835 b0808 ybiO mechanosensitive channel protein, CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.06 -0.13 -0.04 -0.23 0.047 intermediate conductance SIGNALING biogenesis V EcolC_2923 b0733 cydA cytochrome d terminal oxidase, METABOLISM Energy production and 0.49 0.35 0.05 -0.09 0.047 subunit I conversion V EcolC_1550 b2097 fbaB fructose-bisphosphate aldolase METABOLISM Carbohydrate transport and -0.29 0.19 -0.29 0.19 0.047 class I metabolism V EcolC_1348 b2304 yfcH conserved protein with NAD(P)- POORLY CHARACTERIZED General function prediction only 0.12 0.47 -0.04 0.31 0.047 binding Rossmann-fold domain V EcolC_0877 b2838 lysA diaminopimelate decarboxylase, METABOLISM Amino acid transport and 0.20 0.38 0.37 0.55 0.047 PLP-binding metabolism V EcolC_3607 b0048 folA dihydrofolate reductase METABOLISM Coenzyme transport and -0.27 -0.46 -0.14 -0.34 0.047 metabolism V EcolC_2361 b1267 yciO predicted RNA binding protein INFORMATION STORAGE AND Translation, ribosomal structure 0.38 0.10 -0.04 -0.32 0.047 PROCESSING and biogenesis V EcolC_0837 b2871 ygeX 2,3-diaminopropionate ammonia METABOLISM Amino acid transport and -0.70 -0.04 1.08 1.74 0.047 lyase, PLP-dependent metabolism V EcolC_1328 b2324 mnmC fused 5-methylaminomethyl-2- POORLY CHARACTERIZED Function unknown 0.87 0.45 0.39 -0.03 0.047 thiouridine-forming enzyme methyltransferase and FAD- dependent demodification enzyme V EcolC_1839 b1794 yeaP diguanylate cyclase CELLULAR PROCESSES AND Signal transduction mechanisms 0.20 0.47 0.11 0.38 0.047 SIGNALING V EcolC_0819 b2890 lysS lysine tRNA synthetase, INFORMATION STORAGE AND Translation, ribosomal structure 0.35 0.59 0.36 0.59 0.047 constitutive PROCESSING and biogenesis V EcolC_0066 b3645 dinD DNA-damage-inducible protein - - 0.26 0.75 -0.23 0.26 0.047 V EcolC_0755 b2959 yggL conserved protein, DUF469 family POORLY CHARACTERIZED Function unknown -0.22 0.07 0.29 0.58 0.048

V EcolC_3592 b0065 yabI inner membrane protein, POORLY CHARACTERIZED Function unknown -0.16 -0.77 0.81 0.20 0.048 SNARE_assoc family V EcolC_3559 b0098 secA preprotein translocase subunit, CELLULAR PROCESSES AND Intracellular trafficking, 0.28 -0.07 -0.31 -0.67 0.048 ATPase SIGNALING secretion, and vesicular transport

V EcolC_3095 b0527 ybcI inner membrane protein, DUF457 POORLY CHARACTERIZED General function prediction only 0.28 0.46 0.25 0.42 0.048 family V EcolC_3636 - - hypothetical protein - - 0.13 -0.12 0.07 -0.18 0.049 V EcolC_2266 b1389 paaB ring 1,2-phenylacetyl-CoA METABOLISM Secondary metabolites 0.99 0.07 0.11 -0.82 0.050 epoxidase possible subunit, not biosynthesis, transport and required for in vitro activity catabolism VI EcolC_2994 b0651 rihA ribonucleoside hydrolase 1 METABOLISM Nucleotide transport and 0.18 1.85 -0.56 1.11 0.001 metabolism VI EcolC_2426 b1200 dhaK dihydroxyacetone kinase, PTS- METABOLISM Carbohydrate transport and 0.47 1.47 -0.02 0.98 0.001 dependent, dihydroxyacetone- metabolism binding subunit VI EcolC_0828 b2880 ygfM predicted oxidoreductase METABOLISM Energy production and -0.33 1.79 0.89 3.02 0.001 conversion VI EcolC_1004 b2708 gutQ D-arabinose 5-phosphate CELLULAR PROCESSES AND Cell wall/membrane/envelope 0.97 1.70 0.12 0.85 0.002 isomerase SIGNALING biogenesis VI EcolC_1480 b2168 fruK fructose-1-phosphate kinase METABOLISM Carbohydrate transport and 0.14 1.02 0.45 1.33 0.002 metabolism VI EcolC_0698 b2995 hybB predicted hydrogenase 2 METABOLISM Energy production and 0.38 1.14 -0.22 0.54 0.002 cytochrome b type component conversion VI EcolC_1852 b1780 yeaD conserved protein METABOLISM Carbohydrate transport and 0.24 1.28 0.01 1.05 0.004 metabolism VI EcolC_0827 b2881 xdhD probable hypoxanthine oxidase, METABOLISM Energy production and -0.85 1.51 1.13 3.49 0.004 molybdopterin-binding/Fe-S conversion binding VI EcolC_1005 b2707 srlR DNA-bindng transcriptional INFORMATION STORAGE AND Transcription 0.91 1.64 0.14 0.88 0.004 repressor PROCESSING VI EcolC_3170 b0264 insB1 IS1 transposase B INFORMATION STORAGE AND Replication, recombination and 0.31 1.03 0.19 0.91 0.005 PROCESSING repair VI EcolC_2034 b1596 ynfM putative arabinose efflux METABOLISM Carbohydrate transport and 0.18 1.24 0.12 1.18 0.007 transporter metabolism VI EcolC_0842 b2866 xdhA xanthine dehydrogenase, METABOLISM Energy production and 0.51 2.35 0.89 2.73 0.008 molybdenum binding subunit conversion VI EcolC_0580 b3118 tdcA DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.58 1.11 0.14 0.67 0.010 activator PROCESSING VI EcolC_0841 b2867 xdhB xanthine dehydrogenase, FAD- METABOLISM Energy production and -0.03 1.38 0.86 2.27 0.011 binding subunit conversion VI EcolC_3728 b4335 yjiM predicted 2-hydroxyglutaryl-CoA METABOLISM Amino acid transport and 0.65 1.40 0.37 1.12 0.012 dehydratase metabolism VI EcolC_0693 b3001 gpr L-glyceraldehyde 3-phosphate METABOLISM Energy production and 0.74 1.24 -0.08 0.43 0.013 reductase conversion VI EcolC_0246 - sirA sulfur transfer protein SirA CELLULAR PROCESSES AND Posttranslational modification, 0.25 1.24 0.02 1.01 0.019 SIGNALING protein turnover, chaperones VI EcolC_2845 b0798 ybiA conserved protein, DUF1768 POORLY CHARACTERIZED Function unknown 0.92 1.41 0.08 0.58 0.020 family VI EcolC_1505 b2143 cdd cytidine/deoxycytidine deaminase METABOLISM Nucleotide transport and 0.56 1.30 0.10 0.84 0.032 metabolism VI EcolC_0696 b2997 hybO hydrogenase 2, small subunit METABOLISM Energy production and 0.76 1.52 -0.12 0.65 0.034 conversion VI EcolC_1006 b2706 gutM DNA-binding transcriptional INFORMATION STORAGE AND Transcription 0.77 1.22 0.26 0.71 0.038 activator of glucitol operon PROCESSING VI EcolC_3729 b4334 yjiL predicted ATPase, activator of METABOLISM Lipid transport and metabolism 0.71 1.57 0.37 1.22 0.038 (R)-hydroxyglutaryl-CoA dehydratase VI EcolC_2677 b0919 ycbJ conserved protein - - 0.04 1.28 -0.05 1.19 0.038 VI EcolC_0910 b2802 fucI L-fucose isomerase METABOLISM Carbohydrate transport and 0.95 1.27 -0.03 0.29 0.039 metabolism VI EcolC_1534 b2113 mrp antiporter inner membrane protein CELLULAR PROCESSES AND Cell cycle control, cell division, 0.76 1.07 -0.13 0.19 0.041 SIGNALING chromosome partitioning VII EcolC_2933 b0722 sdhD succinate dehydrogenase, METABOLISM Energy production and 2.32 -1.16 0.19 -3.29 0.000 membrane subunit, binds conversion cytochrome b556 VII EcolC_2934 b0721 sdhC succinate dehydrogenase, METABOLISM Energy production and 1.58 -1.13 0.18 -2.53 0.000 membrane subunit, binds conversion cytochrome b556 VII EcolC_3202 b0431 cyoB cytochrome o ubiquinol oxidase METABOLISM Energy production and 1.90 -0.99 0.11 -2.78 0.001 subunit I conversion VIII EcolC_2930 b0726 sucA 2-oxoglutarate decarboxylase, METABOLISM Energy production and 2.01 -0.83 0.20 -2.64 0.000 thiamin-requiring conversion VIII EcolC_2929 b0727 sucB dihydrolipoyltranssuccinase METABOLISM Energy production and 2.20 -0.07 -0.21 -2.48 0.000 conversion VIII EcolC_3772 b4239 treC trehalose-6-P hydrolase METABOLISM Carbohydrate transport and 1.44 -0.04 -0.06 -1.54 0.000 metabolism VIII EcolC_3201 b0432 cyoA cytochrome o ubiquinol oxidase METABOLISM Energy production and 3.21 -0.73 0.17 -3.77 0.000 subunit II conversion VIII EcolC_0189 b3528 dctA C4-dicarboxylic acid, orotate and METABOLISM Energy production and 2.05 -0.16 -0.21 -2.42 0.000 citrate transporter conversion VIII EcolC_2581 b1014 putA fused DNA-binding transcriptional METABOLISM Energy production and 1.93 -0.03 0.18 -1.78 0.000 regulator/proline conversion dehydrogenase/pyrroline-5- carboxylate dehydrogenase VIII EcolC_2991 b0654 gltJ glutamate, aspartate ABC METABOLISM Amino acid transport and 2.31 -0.07 0.16 -2.21 0.001 transporter permease subunit metabolism VIII EcolC_3203 b0430 cyoC cytochrome o ubiquinol oxidase METABOLISM Energy production and 2.09 -0.91 0.06 -2.94 0.001 subunit III conversion VIII EcolC_3153 b0463 acrA multidrug efflux system CELLULAR PROCESSES AND Cell wall/membrane/envelope 2.49 -0.23 -0.56 -3.27 0.001 SIGNALING biogenesis VIII EcolC_2992 b0653 gltK glutamate, aspartate ABC METABOLISM Amino acid transport and 2.10 -0.37 -0.02 -2.49 0.001 transporter permease subunit metabolism VIII EcolC_2746 b0850 ybjC conserved protein, DUF1418 - - 2.46 0.14 -0.26 -2.59 0.001 family VIII EcolC_2848 b0795 ybhG predicted membrane fusion protein CELLULAR PROCESSES AND Defense mechanisms 1.97 -0.10 1.23 -0.84 0.001 (MFP) component of efflux pump, SIGNALING membrane anchor VIII EcolC_2849 b0794 ybhF fused predicted transporter CELLULAR PROCESSES AND Defense mechanisms 2.23 0.06 1.49 -0.68 0.001 subunits of ABC superfamily: SIGNALING ATP-binding components VIII EcolC_2931 b0724 sdhB succinate dehydrogenase, FeS METABOLISM Energy production and 1.33 -0.53 -0.12 -1.99 0.001 subunit conversion VIII EcolC_2350 b1276 acnA aconitate hydratase 1 METABOLISM Energy production and 2.28 0.45 0.01 -1.82 0.001 conversion VIII EcolC_2850 b0793 ybhS predicted transporter subunit: CELLULAR PROCESSES AND Defense mechanisms 1.74 0.20 0.90 -0.64 0.001 membrane component of ABC SIGNALING superfamily VIII EcolC_2927 b0729 sucD succinyl-CoA synthetase, METABOLISM Energy production and 2.64 0.20 -0.24 -2.67 0.001 NAD(P)-binding, alpha subunit conversion VIII EcolC_0505 b3195 mlaF ABC transporter maintaining OM METABOLISM Secondary metabolites 1.07 -0.18 0.08 -1.17 0.001 lipid asymmetry, ATP-binding biosynthesis, transport and protein catabolism VIII EcolC_1366 b2286 nuoC NADH:ubiquinone METABOLISM Energy production and 2.01 0.63 0.30 -1.09 0.002 oxidoreductase, fused CD subunit conversion VIII EcolC_2928 b0728 sucC succinyl-CoA synthetase, beta METABOLISM Energy production and 2.21 0.01 -0.14 -2.34 0.002 subunit conversion VIII EcolC_2318 b1307 pspD peripheral inner membrane phage- - - 2.58 0.12 0.17 -2.28 0.002 shock protein VIII EcolC_2932 b0723 sdhA succinate dehydrogenase, METABOLISM Energy production and 1.86 -0.43 0.13 -2.15 0.003 flavoprotein subunit conversion VIII EcolC_1140 b2537 hcaR DNA-binding transcriptional INFORMATION STORAGE AND Transcription 1.62 0.54 0.36 -0.72 0.003 activator of 3-phenylpropionic PROCESSING acid catabolism VIII EcolC_1364 b2288 nuoA NADH:ubiquinone METABOLISM Energy production and 2.27 0.45 0.39 -1.43 0.003 oxidoreductase, membrane subunit conversion A VIII EcolC_3958 b4069 acs acetyl-CoA synthetase METABOLISM Lipid transport and metabolism 2.31 0.29 0.22 -1.79 0.003 VIII EcolC_2320 b1305 pspB DNA-binding transcriptional - - 2.84 0.27 -0.05 -2.62 0.003 regulator of psp operon VIII EcolC_1370 b2282 nuoH NADH:ubiquinone METABOLISM Energy production and 1.49 0.60 0.32 -0.56 0.003 oxidoreductase, membrane subunit conversion H VIII EcolC_3204 b0429 cyoD cytochrome o ubiquinol oxidase METABOLISM Energy production and 1.46 -0.49 0.12 -1.83 0.004 subunit IV conversion VIII EcolC_0033 b3666 uhpT hexose phosphate transporter METABOLISM Carbohydrate transport and 2.48 0.76 0.04 -1.69 0.004 metabolism VIII EcolC_1414 b2237 inaA conserved protein, acid-induced - - 1.99 0.95 0.41 -0.63 0.004 VIII EcolC_2745 b0851 nfsA nitroreductase A, NADPH- METABOLISM Energy production and 1.93 0.02 -0.09 -2.01 0.004 dependent, FMN-dependent conversion VIII EcolC_1369 b2283 nuoG NADH:ubiquinone METABOLISM Energy production and 1.43 0.44 0.24 -0.74 0.005 oxidoreductase, chain G conversion VIII EcolC_0750 b2964 nupG nucleoside transporter METABOLISM Carbohydrate transport and 1.51 0.67 -0.32 -1.16 0.005 metabolism VIII EcolC_3114 b0508 hyi hydroxypyruvate isomerase METABOLISM Carbohydrate transport and 3.29 0.59 -0.02 -2.72 0.005 metabolism VIII EcolC_2047 b1583 ynfB predicted protein - - 1.30 0.28 0.37 -0.65 0.005 VIII EcolC_3505 b0154 hemL glutamate-1-semialdehyde METABOLISM Coenzyme transport and 1.00 0.41 -0.20 -0.79 0.005 aminotransferase (aminomutase) metabolism VIII EcolC_2319 b1306 pspC DNA-binding transcriptional INFORMATION STORAGE AND Transcription 2.86 -0.20 -0.34 -3.40 0.006 activator PROCESSING VIII EcolC_2128 b1530 marR DNA-binding transcriptional INFORMATION STORAGE AND Transcription 1.76 0.47 0.12 -1.17 0.007 repressor of multiple antibiotic PROCESSING resistance VIII EcolC_2474 b1129 phoQ sensory histidine kinase in two- CELLULAR PROCESSES AND Signal transduction mechanisms 1.10 0.21 -0.01 -0.90 0.008 component regulatory system with SIGNALING PhoP VIII EcolC_0650 b3049 glgS motility and biofilm regulator - - 1.28 -0.62 -1.23 -3.13 0.008 VIII EcolC_0110 b4554 yibT predicted protein - - 1.39 -0.25 -1.05 -2.68 0.009 VIII EcolC_3965 b4062 soxS DNA-binding transcriptional dual INFORMATION STORAGE AND Transcription 2.03 0.74 0.31 -0.98 0.010 regulator PROCESSING VIII EcolC_1368 b2284 nuoF NADH:ubiquinone METABOLISM Energy production and 1.23 0.53 0.18 -0.52 0.010 oxidoreductase, chain F conversion VIII EcolC_3989 b4039 ubiC chorismate--pyruvate lyase METABOLISM Coenzyme transport and 2.27 -0.17 0.18 -2.27 0.011 metabolism VIII EcolC_0839 b2869 ygeV predicted DNA-binding INFORMATION STORAGE AND Transcription 1.35 0.56 0.22 -0.57 0.011 transcriptional regulator PROCESSING VIII EcolC_3988 b4040 ubiA p-hydroxybenzoate METABOLISM Coenzyme transport and 1.04 0.29 0.26 -0.49 0.011 octaprenyltransferase metabolism VIII EcolC_1365 b2287 nuoB NADH:ubiquinone METABOLISM Energy production and 1.96 0.63 0.43 -0.90 0.011 oxidoreductase, chain B conversion VIII EcolC_3154 b0462 acrB multidrug efflux system protein CELLULAR PROCESSES AND Defense mechanisms 1.28 -0.24 -0.54 -2.06 0.011 SIGNALING VIII EcolC_2321 b1304 pspA regulatory protein for phage- INFORMATION STORAGE AND Transcription 2.88 0.27 0.03 -2.58 0.011 shock-protein operon PROCESSING VIII EcolC_2935 b0720 gltA citrate synthase METABOLISM Energy production and 1.65 0.01 -0.11 -1.75 0.012 conversion VIII EcolC_3138 b0478 ybaL predicted transporter with METABOLISM Inorganic ion transport and 1.36 0.16 -0.30 -1.49 0.012 NAD(P)-binding Rossmann-fold metabolism domain VIII EcolC_3674 b4382 deoA thymidine phosphorylase METABOLISM Nucleotide transport and 1.16 0.58 -0.09 -0.67 0.012 metabolism VIII EcolC_3205 b0428 cyoE protoheme IX farnesyltransferase CELLULAR PROCESSES AND Posttranslational modification, 1.26 -0.29 0.19 -1.36 0.014 SIGNALING protein turnover, chaperones VIII EcolC_2127 b1531 marA DNA-binding transcriptional dual INFORMATION STORAGE AND Transcription 2.28 0.61 0.09 -1.58 0.016 activator of multiple antibiotic PROCESSING resistance VIII EcolC_4242 b3752 rbsK ribokinase METABOLISM Carbohydrate transport and 1.28 0.87 -0.15 -0.57 0.017 metabolism VIII EcolC_3675 b4381 deoC 2-deoxyribose-5-phosphate METABOLISM Nucleotide transport and 1.52 0.65 -0.09 -0.96 0.018 aldolase, NAD(P)-linked metabolism VIII EcolC_0111 b3601 mtlR mannitol operon repressor INFORMATION STORAGE AND Transcription 1.51 -0.13 -0.16 -1.80 0.018 PROCESSING VIII EcolC_1889 b1743 spy periplasmic ATP-independent CELLULAR PROCESSES AND Intracellular trafficking, 2.40 0.99 0.27 -1.15 0.018 protein refolding chaperone, SIGNALING secretion, and vesicular transport stress-induced VIII EcolC_1253 b2426 ucpA furfural resistance protein, METABOLISM Lipid transport and metabolism 1.72 0.88 -0.20 -1.04 0.022 predicted short-chain oxidoreductase VIII EcolC_3143 b0473 htpG protein refolding molecular co- CELLULAR PROCESSES AND Posttranslational modification, 1.23 0.71 0.08 -0.44 0.030 chaperone Hsp90, Hsp70- SIGNALING protein turnover, chaperones dependent; heat-shock protein; ATPase VIII EcolC_4245 b3749 rbsA fused D-ribose transporter METABOLISM Carbohydrate transport and 1.97 0.91 0.30 -0.76 0.030 subunits of ABC superfamily: metabolism ATP-binding components VIII EcolC_1250 b2429 murP N-acetylmuramic acid permease, METABOLISM Carbohydrate transport and 1.20 0.27 -0.01 -0.94 0.041 EIIBC component, PTS system metabolism VIII EcolC_0723 b4467 glcF glycolate oxidase 4Fe-4S iron- METABOLISM Energy production and 1.24 0.26 0.08 -0.91 0.042 sulfur cluster subunit conversion VIII EcolC_3117 b0505 allA ureidoglycolate hydrolase METABOLISM Nucleotide transport and 1.24 0.50 0.05 -0.69 0.044 metabolism VIII EcolC_3115 b0507 gcl glyoxylate carboligase POORLY CHARACTERIZED General function prediction only 2.74 0.77 -0.04 -2.01 0.045 VIIII EcolC_2990 b0655 gltI glutamate, aspartate binding METABOLISM Amino acid transport and 4.57 1.22 0.29 -3.06 0.000 protein, periplasmic; part of metabolism GltJKLI ABC transporter VIIII EcolC_2178 b1479 maeA malate dehydrogenase, METABOLISM Energy production and 1.61 1.00 0.16 -0.44 0.000 (decarboxylating, NAD-requiring) conversion (malic enzyme) VIIII EcolC_0724 b2977 glcG conserved protein POORLY CHARACTERIZED General function prediction only 2.12 1.44 -0.31 -0.99 0.001 VIIII EcolC_1409 b2242 glpB sn-glycerol-3-phosphate METABOLISM Amino acid transport and 1.70 2.81 0.76 1.87 0.001 dehydrogenase (anaerobic), metabolism membrane anchor subunit VIIII EcolC_0812 b2897 sdhE flavinator of succinate POORLY CHARACTERIZED Function unknown 1.12 1.60 0.01 0.50 0.002 dehydrogenase; antitoxin of CptAB toxin-antitoxin pair VIIII EcolC_3111 b0512 allB allantoinase METABOLISM Nucleotide transport and 6.16 4.70 -0.09 -1.54 0.002 metabolism VIIII EcolC_1089 b2592 clpB protein disaggregation chaperone CELLULAR PROCESSES AND Posttranslational modification, 2.41 1.35 0.18 -0.89 0.002 SIGNALING protein turnover, chaperones VIIII EcolC_1410 b2241 glpA sn-glycerol-3-phosphate METABOLISM Energy production and 2.07 2.98 0.51 1.42 0.002 dehydrogenase (anaerobic), large conversion subunit, FAD/NAD(P)-binding VIIII EcolC_1408 b2243 glpC anaerobic sn-glycerol-3-phosphate METABOLISM Energy production and 1.34 2.39 0.78 1.83 0.003 dehydrogenase, C subunit, 4Fe-4S conversion iron-sulfur cluster VIIII EcolC_3870 b4142 groS Cpn10 chaperonin GroES, small CELLULAR PROCESSES AND Posttranslational modification, 2.63 1.99 -0.50 -1.14 0.003 subunit of GroESL SIGNALING protein turnover, chaperones VIIII EcolC_1038 b2668 ygaP predicted inner membrane protein METABOLISM Inorganic ion transport and 1.46 1.06 0.00 -0.40 0.006 with hydrolase activity metabolism VIIII EcolC_4091 b3927 glpF glycerol facilitator METABOLISM Carbohydrate transport and 3.28 2.02 0.62 -0.65 0.011 metabolism VIIII EcolC_3113 b0509 glxR tartronate semialdehyde reductase, METABOLISM Lipid transport and metabolism 4.15 1.60 -0.16 -2.71 0.013 NADH-dependent VIIII EcolC_1411 b2240 glpT sn-glycerol-3-phosphate METABOLISM Carbohydrate transport and 3.49 2.86 0.36 -0.27 0.013 transporter metabolism VIIII EcolC_2019 b1611 fumC fumarate hydratase (fumarase METABOLISM Energy production and 3.06 1.06 0.24 -1.76 0.014 C),aerobic Class II conversion VIIII EcolC_0725 b2976 glcB malate synthase G METABOLISM Energy production and 2.17 1.10 -0.12 -1.19 0.019 conversion VIIII EcolC_3673 b4383 deoB phosphopentomutase METABOLISM Carbohydrate transport and 1.81 1.44 -0.35 -0.72 0.020 metabolism VIIII EcolC_1375 b2277 nuoM NADH:ubiquinone METABOLISM Energy production and 1.14 1.58 0.06 0.49 0.026 oxidoreductase, membrane subunit conversion M VIIII EcolC_0288 b3426 glpD sn-glycerol-3-phosphate METABOLISM Energy production and 2.35 1.38 0.43 -0.54 0.027 dehydrogenase, aerobic, conversion FAD/NAD(P)-binding VIIII EcolC_3869 b4143 groL Cpn60 chaperonin GroEL, large CELLULAR PROCESSES AND Posttranslational modification, 2.69 2.03 -0.30 -0.96 0.031 subunit of GroESL SIGNALING protein turnover, chaperones

VIIII EcolC_4092 b3926 glpK glycerol kinase METABOLISM Energy production and 2.49 1.96 0.26 -0.27 0.032 conversion VIIII EcolC_4093 b3925 glpX fructose 1,6-bisphosphatase II METABOLISM Carbohydrate transport and 2.03 1.62 0.39 -0.01 0.035 metabolism VIIII EcolC_1413 b2238 yfaH - - - 1.47 2.27 0.63 1.44 0.041 VIIII EcolC_4023 b4002 zraP Zn-dependent periplasmic CELLULAR PROCESSES AND Intracellular trafficking, 1.54 4.08 0.14 2.68 0.049 chaperone SIGNALING secretion, and vesicular transport Supplementary Table S3. GO enrichment analysis for the enriched biological processes in DEGs

Observed Pathway ID Pathway description FDR Matching proteins in your network (IDs) Matching proteins in your network (labels) gene count GO.0006091 generation of precursor 63 2.38E-16 b0114,b0115,b0116,b0118,b0156,b0429,b0430,b0431,b0432, aceA,aceE,aceF,acnA,acnB,aspA,cybB,cydA,cyoA,c metabolites and energy b0720,b0721,b0722,b0723,b0724,b0726,b0727,b0728,b0729, yoB,cyoC,cyoD,dld,dmsA,dmsB,dmsC,dsbB,eno,erp b0733,b0894,b0895,b0896,b0903,b1185,b1276,b1418,b1475, A,fbaB,fdnH,fdoG,fdoH,fdoI,frdA,frdC,frdD,fumB,f b1587,b1588,b1589,b1590,b1611,b1670,b1723,b1779,b2097, umC,gapA,glcB,gldA,glgS,glk,glpC,gltA,gpmI,lpd,m b2133,b2243,b2277,b2282,b2283,b2284,b2287,b2388,b2779, alP,malQ,nuoB,nuoF,nuoG,nuoH,nuoM,pfkB,pflB,p b2976,b3049,b3416,b3417,b3573,b3612,b3892,b3893,b3894, gi,sdhA,sdhB,sdhC,sdhD,sucA,sucB,sucC,sucD,tpiA b3919,b3945,b4015,b4025,b4122,b4139,b4151,b4152,b4154 ,ydhU,yiaI,ynfE,ynfF,ynfG,ynfH GO.0015980 energy derivation by 50 6.47E-13 b0118,b0156,b0429,b0430,b0431,b0432,b0720,b0721,b0722, aceA,acnA,acnB,aspA,cybB,cydA,cyoA,cyoB,cyoC, oxidation of organic b0723,b0724,b0726,b0727,b0728,b0729,b0733,b0894,b0895, cyoD,dld,dmsA,dmsB,dmsC,erpA,fdnH,fdoG,fdoH,f compounds b0896,b0903,b1276,b1418,b1475,b1587,b1588,b1589,b1590, doI,frdA,frdC,frdD,fumB,fumC,glcB,gldA,glgS,gltA, b1611,b1670,b2133,b2277,b2282,b2283,b2284,b2287,b2976, malP,malQ,nuoB,nuoF,nuoG,nuoH,nuoM,pflB,sdhA b3049,b3416,b3417,b3573,b3892,b3893,b3894,b3945,b4015, ,sdhB,sdhC,sdhD,sucA,sucB,sucC,sucD,ydhU,yiaI,y b4122,b4139,b4151,b4152,b4154 nfE,ynfF,ynfG,ynfH GO.0045333 cellular respiration 46 1.59E-12 b0118,b0156,b0429,b0430,b0431,b0432,b0720,b0721,b0722, aceA,acnA,acnB,aspA,cybB,cydA,cyoA,cyoB,cyoC, b0723,b0724,b0726,b0727,b0728,b0729,b0733,b0894,b0895, cyoD,dld,dmsA,dmsB,dmsC,erpA,fdnH,fdoG,fdoH,f b0896,b0903,b1276,b1418,b1475,b1587,b1588,b1589,b1590, doI,frdA,frdC,frdD,fumB,fumC,glcB,gltA,nuoB,nuo b1611,b1670,b2133,b2277,b2282,b2283,b2284,b2287,b2976, F,nuoG,nuoH,nuoM,pflB,sdhA,sdhB,sdhC,sdhD,suc b3573,b3892,b3893,b3894,b4015,b4122,b4139,b4151,b4152, A,sucB,sucC,sucD,ydhU,yiaI,ynfE,ynfF,ynfG,ynfH GO.0009060 aerobic respiration 28 1.69E-10 b0118,b0156,b0429,b0430,b0431,b0432,b0720,b0721,b0722, aceA,acnA,acnB,aspA,cydA,cyoA,cyoB,cyoC,cyoD, b0723,b0724,b0726,b0727,b0728,b0729,b0733,b1276,b1611, dld,erpA,fumB,fumC,glcB,gltA,nuoB,nuoF,nuoG,nu b2133,b2277,b2282,b2283,b2284,b2287,b2976,b4015,b4122, oH,nuoM,sdhA,sdhB,sdhC,sdhD,sucA,sucB,sucC,su b4139 cD GO.0055114 oxidation-reduction 122 1.65E-09 b0048,b0114,b0115,b0116,b0118,b0156,b0221,b0312,b0419, aceA,aceE,aceF,acnA,acnB,acuI,adhE,ahpC,ahpF,asd process b0429,b0430,b0431,b0432,b0509,b0605,b0606,b0658,b0720, ,aspA,b4467,betB,bfr,corC,curA,cybB,cydA,cyoA,cy b0721,b0722,b0723,b0724,b0726,b0727,b0728,b0729,b0733, oB,cyoC,cyoD,dadA,dkgA,dld,dmsA,dmsB,dmsC,dp b0812,b0851,b0894,b0895,b0896,b0903,b1014,b1093,b1185, s,dsbB,epd,erpA,fabG,fadD,fadE,fadJ,fdhF,fdnH,fdo b1189,b1241,b1276,b1313,b1388,b1392,b1395,b1406,b1418, G,fdoH,fdoI,fdx,folA,frdA,frdC,frdD,ftnA,fumB,fum b1449,b1475,b1479,b1539,b1587,b1588,b1589,b1590,b1611, C,gapA,gcvP,glcB,gldA,glgS,glpA,glpB,glpC,glpD,g b1647,b1670,b1673,b1674,b1765,b1778,b1779,b1805,b1905, ltA,glxR,gpr,grxC,hemG,hybB,hybO,lpd,maeA,malP b2063,b2133,b2172,b2235,b2236,b2241,b2242,b2243,b2277, ,malQ,mdaA,melA,mnmC,msrB,nrdB,nuoA,nuoB,nu b2282,b2283,b2284,b2286,b2287,b2288,b2324,b2341,b2426, oC,nuoF,nuoG,nuoH,nuoM,paaA,paaE,paaH,pflB,pu b2525,b2866,b2867,b2868,b2878,b2880,b2881,b2903,b2907, tA,sdhA,sdhB,sdhC,sdhD,sthA,sucA,sucB,sucC,suc b2927,b2976,b2995,b2997,b3001,b3012,b3049,b3087,b3160, D,ubiH,ucpA,xdhA,xdhB,xdhC,xdhD,yajO,ycjQ,ydb b3253,b3336,b3416,b3417,b3426,b3433,b3573,b3610,b3850, C,ydfG,ydhF,ydhU,ydhV,ydhY,ydjA,yegH,yeiQ,yfa b3892,b3893,b3894,b3945,b3962,b4015,b4079,b4119,b4122, E,ygfK,ygfM,ygjR,yhbW,yiaI,ynfE,ynfF,ynfG,ynfH b4139,b4151,b4152,b4154,b4467 GO.0044712 single-organism 85 3.98E-08 b0114,b0115,b0116,b0118,b0221,b0418,b0480,b0505,b0507, aceE,aceF,acnB,acs,allA,astC,b4467,cdd,dadA,dcyD, catabolic process b0509,b0651,b0677,b0726,b0727,b0947,b1014,b1189,b1200, deoB,deoC,dgoK,dhaK,dkgA,eno,fadD,fadE,fadJ,fba b1388,b1389,b1391,b1392,b1394,b1395,b1539,b1613,b1723, B,fruK,fucI,gapA,garD,gcl,gcvP,gcvT,glcB,gldA,glk, b1748,b1779,b1805,b1814,b1919,b2097,b2143,b2168,b2241, glpA,glpB,glpC,glpD,glpK,glxR,gntT,gntX,gpmI,kbl b2242,b2243,b2297,b2341,b2388,b2744,b2779,b2802,b2866, ,lpd,malP,malQ,manA,melA,nagA,paaA,paaB,paaD, b2867,b2868,b2871,b2881,b2903,b2905,b2976,b3012,b3113, paaE,paaG,paaH,pfkB,pgi,pgpA,pta,putA,rbsD,rbsK, b3114,b3117,b3118,b3128,b3386,b3413,b3415,b3416,b3417, rhaA,rhaB,rhaD,rhaM,rihA,rpe,sdaA,sgaH,sucA,suc b3426,b3612,b3617,b3693,b3748,b3752,b3901,b3902,b3903, B,surE,tdcA,tdcB,tdcE,tdcF,tdcG,tpiA,treC,ushA,xd b3904,b3919,b3926,b3945,b4025,b4069,b4119,b4196,b4239, hA,xdhB,xdhC,xdhD,ycbX,ydfG,ygeX b4381,b4383,b4467,b4471 GO.0044710 single-organism 263 3.46E-07 b0034,b0048,b0090,b0096,b0103,b0114,b0115,b0116,b0118, aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,acs,acuI, metabolic process b0154,b0156,b0179,b0180,b0221,b0274,b0312,b0313,b0314, adhE,aec38,aec39,ahpC,ahpF,allA,allB,ansB,arnF,ar b0369,b0418,b0419,b0428,b0429,b0430,b0431,b0432,b0444, oF,asd,aspA,astC,atpF,b4467,betB,betI,betT,bfr,caiF, b0472,b0475,b0480,b0494,b0505,b0507,b0508,b0509,b0511, cdd,cfa,coaE,corC,curA,cybB,cydA,cyoA,cyoB,cyoC b0512,b0526,b0605,b0606,b0651,b0658,b0677,b0714,b0720, ,cyoD,cyoE,cysQ,cysS,dacB,dacC,dadA,dadX,dapA, b0721,b0722,b0723,b0724,b0726,b0727,b0728,b0729,b0733, dapE,dapF,dcyD,deoA,deoB,deoC,dgoK,dhaK,dkgA, b0812,b0839,b0851,b0894,b0895,b0896,b0903,b0947,b1014, dld,dmsA,dmsB,dmsC,dps,dsbB,eno,epd,erpA,evgS, b1062,b1092,b1093,b1094,b1129,b1131,b1185,b1189,b1190, fabB,fabD,fabG,fabR,fabZ,fadD,fadE,fadJ,fbaB,fdhF b1200,b1241,b1262,b1276,b1279,b1297,b1313,b1388,b1389, ,fdnH,fdoG,fdoH,fdoI,fdx,folA,frdA,frdC,frdD,fruK, b1391,b1392,b1394,b1395,b1406,b1418,b1449,b1469,b1475, fsaB,ftnA,fucI,fucU,fumB,fumC,gapA,garD,gcl,gcvP b1479,b1539,b1587,b1588,b1589,b1590,b1593,b1611,b1613, ,gcvT,gip,glcB,gldA,glgS,glk,glpA,glpB,glpC,glpD,g b1622,b1637,b1647,b1661,b1670,b1673,b1674,b1680,b1702, lpK,glpT,glpX,gltA,glxR,gntT,gntX,gpmI,gpr,grxC,g b1713,b1719,b1723,b1748,b1765,b1778,b1779,b1805,b1814, utQ,hemB,hemC,hemG,hemH,hemL,hldE,hybB,hyb b1863,b1905,b1919,b2063,b2097,b2133,b2143,b2159,b2168, O,ilvM,kbl,lpd,lpxC,lpxD,lysA,lysS,maeA,malP,mal b2172,b2218,b2235,b2236,b2240,b2241,b2242,b2243,b2258, Q,malY,manA,mdaA,melA,menB,mnmC,msrB,mtg b2262,b2277,b2282,b2283,b2284,b2286,b2287,b2288,b2296, A,mug,murG,mutS,nagA,narU,nei,nfo,nrdB,nuoA,nu b2297,b2323,b2324,b2341,b2370,b2388,b2426,b2472,b2478, oB,nuoC,nuoF,nuoG,nuoH,nuoM,paaA,paaB,paaD,p b2498,b2501,b2525,b2563,b2564,b2601,b2708,b2733,b2744, aaE,paaG,paaH,pck,pdxJ,pfkB,pflB,pgi,pgpA,pheT,p b2779,b2802,b2804,b2838,b2866,b2867,b2868,b2870,b2871, hoQ,ppk,pps,pta,purA,purB,putA,puuA,pyrC,queC,r b2878,b2880,b2881,b2890,b2903,b2905,b2907,b2914,b2927, bsD,rbsK,rcsC,recR,rfaG,rhaA,rhaB,rhaD,rhaM,rhaR b2957,b2976,b2995,b2997,b3001,b3012,b3049,b3052,b3068, ,ridA,rihA,rpe,rpiA,ruvC,sdaA,sdhA,sdhB,sdhC,sdh b3087,b3113,b3114,b3117,b3118,b3128,b3160,b3182,b3208, D,selA,selB,sgaH,spoT,sthA,sucA,sucB,sucC,sucD,s b3253,b3336,b3386,b3403,b3413,b3415,b3416,b3417,b3426, ufS,surE,tdcA,tdcB,tdcE,tdcF,tdcG,tesA,thrS,tpiA,tre b3433,b3573,b3590,b3591,b3610,b3612,b3617,b3631,b3650, C,trpC,tyrS,ubiA,ubiC,ubiH,ucpA,upp,ushA,xdhA,x b3693,b3736,b3748,b3752,b3769,b3805,b3809,b3834,b3850, dhB,xdhC,xdhD,yajO,ybbW,ycbX,yciS,ycjQ,ydbC,y b3892,b3893,b3894,b3901,b3902,b3903,b3904,b3906,b3919, dfG,ydhF,ydhU,ydhV,ydhY,ydjA,yegH,yeiQ,yfaE,yg b3925,b3926,b3945,b3946,b3962,b3963,b4015,b4025,b4039, eW,ygeX,ygfK,ygfM,ygjR,yhbW,yiaI,yigP,ynfE,ynf b4040,b4069,b4079,b4119,b4122,b4139,b4151,b4152,b4154, F,ynfG,ynfH,ynfK b4177,b4196,b4214,b4239,b4243,b4294,b4381,b4382,b4383, GO.1901575 organic substance 98 1.25E-06 b0114,b0115,b0116,b0118,b0161,b0221,b0418,b0480,b0505, aceE,aceF,acnB,acs,allA,allB,amiD,astC,b4467,bcsZ catabolic process b0507,b0509,b0512,b0651,b0677,b0726,b0727,b0867,b1014, ,cdd,chpA,dacB,dadA,dcyD,deaD,degP,degQ,deoB,d b1084,b1189,b1200,b1297,b1388,b1389,b1391,b1392,b1394, eoC,dgoK,dhaK,dkgA,eno,fadD,fadE,fadJ,fbaB,fruK b1395,b1539,b1584,b1613,b1723,b1748,b1779,b1805,b1814, ,ftsH,fucI,gapA,garD,gcl,gcvP,gcvT,glcB,gldA,glk,gl b1919,b2097,b2143,b2168,b2241,b2242,b2243,b2297,b2341, pA,glpB,glpC,glpD,glpK,glxR,gntT,gntX,gpmI,kbl,l b2388,b2744,b2779,b2782,b2802,b2830,b2866,b2867,b2868, pd,malP,malQ,manA,melA,nagA,nudH,paaA,paaB,p b2871,b2881,b2903,b2905,b2976,b3012,b3113,b3114,b3117, aaD,paaE,paaG,paaH,pfkB,pgi,pgpA,pta,putA,puuA, b3118,b3128,b3162,b3178,b3182,b3234,b3386,b3413,b3415, rbsD,rbsK,rhaA,rhaB,rhaD,rhaM,rihA,rne,rpe,rraB,s b3416,b3417,b3426,b3531,b3612,b3617,b3693,b3748,b3752, daA,sgaH,speG,sucA,sucB,surE,tdcA,tdcB,tdcE,tdcF b3901,b3902,b3903,b3904,b3919,b3926,b3945,b4025,b4069, ,tdcG,tpiA,treC,ushA,xdhA,xdhB,xdhC,xdhD,ydfG,y b4119,b4196,b4239,b4255,b4381,b4383,b4467,b4471 geX GO.0009056 catabolic process 100 1.42E-06 b0114,b0115,b0116,b0118,b0161,b0221,b0418,b0480,b0505, aceE,aceF,acnB,acs,allA,allB,amiD,astC,b4467,bcsZ b0507,b0509,b0512,b0651,b0677,b0726,b0727,b0867,b0947, ,cdd,chpA,dacB,dadA,dcyD,deaD,degP,degQ,deoB,d b1014,b1084,b1189,b1200,b1297,b1388,b1389,b1391,b1392, eoC,dgoK,dhaK,dkgA,eno,fadD,fadE,fadJ,fbaB,fruK b1394,b1395,b1539,b1584,b1613,b1635,b1723,b1748,b1779, ,ftsH,fucI,gapA,garD,gcl,gcvP,gcvT,glcB,gldA,glk,gl b1805,b1814,b1919,b2097,b2143,b2168,b2241,b2242,b2243, pA,glpB,glpC,glpD,glpK,glxR,gntT,gntX,gpmI,gst,k b2297,b2341,b2388,b2744,b2779,b2782,b2802,b2830,b2866, bl,lpd,malP,malQ,manA,melA,nagA,nudH,paaA,paa b2867,b2868,b2871,b2881,b2903,b2905,b2976,b3012,b3113, B,paaD,paaE,paaG,paaH,pfkB,pgi,pgpA,pta,putA,pu b3114,b3117,b3118,b3128,b3162,b3178,b3182,b3234,b3386, uA,rbsD,rbsK,rhaA,rhaB,rhaD,rhaM,rihA,rne,rpe,rra b3413,b3415,b3416,b3417,b3426,b3531,b3612,b3617,b3693, B,sdaA,sgaH,speG,sucA,sucB,surE,tdcA,tdcB,tdcE,t b3748,b3752,b3901,b3902,b3903,b3904,b3919,b3926,b3945, dcF,tdcG,tpiA,treC,ushA,xdhA,xdhB,xdhC,xdhD,yc b4025,b4069,b4119,b4196,b4239,b4255,b4381,b4383,b4467, bX,ydfG,ygeX GO.0006099 tricarboxylic acid cycle 16 2.23E-06b4471 b0118,b0720,b0721,b0722,b0723,b0724,b0726,b0727,b0728, aceA,acnA,acnB,aspA,fumB,fumC,glcB,gltA,sdhA,s b0729,b1276,b1611,b2976,b4015,b4122,b4139 dhB,sdhC,sdhD,sucA,sucB,sucC,sucD GO.0008152 metabolic process 417 2.96E-06 b0034,b0048,b0090,b0095,b0096,b0098,b0103,b0114,b0115, ECs3957,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acp b0116,b0118,b0154,b0156,b0161,b0179,b0180,b0221,b0239, S,acs,acuI,adhE,aec38,aec39,agaS,ahpC,ahpF,allA,al b0274,b0312,b0313,b0314,b0369,b0418,b0419,b0428,b0429, lB,alsA,amiD,ansB,arcA2,arnF,aroF,artP,asd,aspA,as b0430,b0431,b0432,b0438,b0444,b0460,b0472,b0473,b0475, tC,atpF,b2726,b4467,bcsZ,betB,betI,betT,bfr,cadC,c b0480,b0494,b0505,b0507,b0508,b0509,b0511,b0512,b0526, aiF,cdd,cfa,chpA,clpB,clpX,coaE,corC,crp,cspA,csp b0572,b0581,b0605,b0606,b0651,b0658,b0659,b0677,b0683, C,curA,cusC,cybB,cydA,cyoA,cyoB,cyoC,cyoD,cyo b0698,b0714,b0720,b0721,b0722,b0723,b0724,b0726,b0727, E,cysQ,cysS,dacB,dacC,dadA,dadX,dapA,dapE,dapF b0728,b0729,b0733,b0794,b0796,b0809,b0812,b0817,b0839, ,dcyD,deaD,degP,degQ,deoA,deoB,deoC,dgoK,dhaK b0851,b0852,b0864,b0867,b0894,b0895,b0896,b0897,b0903, ,dkgA,dld,dmsA,dmsB,dmsC,dnaG,dps,dsbB,eno,ep b0919,b0920,b0924,b0947,b0975,b1014,b1062,b1079,b1084, d,erpA,evgS,fabB,fabD,fabG,fabR,fabZ,fadD,fadE,fa b1089,b1092,b1093,b1094,b1123,b1129,b1130,b1131,b1185, dJ,fbaB,fdhE,fdhF,fdnH,fdoG,fdoH,fdoI,fdx,fic,flgH, b1189,b1190,b1200,b1237,b1241,b1247,b1262,b1266,b1276, folA,frdA,frdC,frdD,frsA,fruK,fsaB,ftnA,ftsH,ftsZ,fu b1279,b1297,b1305,b1306,b1313,b1388,b1389,b1391,b1392, cI,fucU,fumB,fumC,fur,fusA,gadX,gapA,garD,gcl,gc b1394,b1395,b1406,b1418,b1449,b1469,b1475,b1479,b1513, vP,gcvT,gip,glcB,gldA,glgS,glk,glnQ,glpA,glpB,glp b1530,b1531,b1535,b1539,b1584,b1587,b1588,b1589,b1590, C,glpD,glpK,glpT,glpX,gltA,glxR,gntT,gntX,gpmI,g b1593,b1611,b1613,b1622,b1635,b1637,b1647,b1661,b1670, pr,groL,groS,grxC,gshA,gst,gutM,gutQ,hcaR,hemB, b1673,b1674,b1680,b1682,b1683,b1684,b1702,b1713,b1717, hemC,hemG,hemH,hemL,hha,hldE,hns,holE,hscA,ht b1719,b1723,b1724,b1743,b1748,b1765,b1770,b1778,b1779, pG,htpX,hyaD,hybB,hybD,hybE,hybF,hybO,hypB,h b1780,b1794,b1805,b1814,b1818,b1819,b1823,b1826,b1829, ypC,hypD,hypE,icc,ilvM,inaA,kbl,kdpA,lgt,lpd,lpxC b1842,b1863,b1905,b1919,b2063,b2097,b2110,b2133,b2143, ,lpxD,lrhA,lsrA,lysA,lysS,maeA,malF,malG,malK,m b2159,b2168,b2172,b2180,b2218,b2235,b2236,b2237,b2240, alP,malQ,malY,manA,manY,manZ,marA,marR,maz b2241,b2242,b2243,b2258,b2262,b2277,b2282,b2283,b2284, G,mdaA,melA,menB,mgrB,mlaF,mnmC,mntR,msrB, b2286,b2287,b2288,b2289,b2293,b2296,b2297,b2304,b2323, mtgA,mtlR,mug,mukB,murG,murP,mutS,nagA,narU, b2324,b2341,b2370,b2388,b2426,b2429,b2465,b2472,b2478, nei,nfo,nrdB,nudH,nuoA,nuoB,nuoC,nuoF,nuoG,nuo b2498,b2501,b2525,b2526,b2537,b2563,b2564,b2572,b2581, H,nuoM,ompR,oppF,paaA,paaB,paaD,paaE,paaG,pa b2592,b2601,b2608,b2609,b2688,b2706,b2707,b2708,b2726, aH,pck,pdxJ,pfkB,pflB,pgi,pgpA,pheT,phoP,phoQ,p b2727,b2728,b2729,b2730,b2733,b2744,b2779,b2781,b2782, otD,ppk,pps,prfB,priB,pspB,pspC,pta,ptsN,purA,pur b2802,b2804,b2806,b2828,b2830,b2838,b2866,b2867,b2868, B,putA,puuA,pyrC,queC,rbbA,rbsA,rbsD,rbsK,rcsC, b2869,b2870,b2871,b2872,b2878,b2879,b2880,b2881,b2890, recR,rfaG,rhaA,rhaB,rhaD,rhaM,rhaR,ridA,rihA,rim b2891 b2903 b290 b290 b2914 b292 b29 b2960 b29 6 i l l iAlAllCl GO.0008150 biological_process 507 3.64E-06 b0034,b0048,b0065,b0090,b0095,b0096,b0098,b0103,b0114, ECs3957,aaeA,aceA,aceE,aceF,ackA,acnA,acnB,acp b0115,b0116,b0118,b0154,b0155,b0156,b0161,b0179,b0180, P,acpS,acrA,acrB,acs,acuI,adhE,aec38,aec39,agaS,ah b0221,b0239,b0274,b0312,b0313,b0314,b0369,b0411,b0418, pC,ahpF,allA,allB,alsA,amiD,ansB,arcA2,argT,arnF, b0419,b0428,b0429,b0430,b0431,b0432,b0438,b0444,b0460, aroF,artP,asd,aspA,astC,atpF,atpI,b2726,b4467,bam b0462,b0463,b0472,b0473,b0475,b0478,b0480,b0494,b0505, D,bcsZ,betB,betI,betT,bfr,cadC,caiF,cbpM,cdd,cfa,c b0507,b0508,b0509,b0511,b0512,b0526,b0572,b0581,b0605, heW,chpA,clcA,clpB,clpX,coaE,corC,crp,csiE,cspA, b0606,b0621,b0651,b0653,b0654,b0655,b0658,b0659,b0677, cspC,cspD,curA,cusC,cybB,cydA,cyoA,cyoB,cyoC,c b0683,b0698,b0714,b0720,b0721,b0722,b0723,b0724,b0726, yoD,cyoE,cysQ,cysS,dacB,dacC,dadA,dadX,dapA,da b0727,b0728,b0729,b0733,b0793,b0794,b0795,b0796,b0808, pE,dapF,dctA,dcuA,dcuB,dcuC,dcyD,deaD,degP,deg b0809,b0811,b0812,b0817,b0839,b0851,b0852,b0864,b0867, Q,deoA,deoB,deoC,dgoK,dhaK,dinD,dkgA,dld,dms b0877,b0880,b0891,b0894,b0895,b0896,b0897,b0903,b0904, A,dmsB,dmsC,dnaG,dppA,dppB,dps,dsbB,dtpB,ecfL b0919,b0920,b0924,b0947,b0970,b0975,b0999,b1014,b1062, ,ecfM,elaB,eno,epd,erpA,evgS,fabB,fabD,fabG,fabR, b1073,b1074,b1075,b1076,b1077,b1079,b1084,b1089,b1092, fabZ,fadD,fadE,fadJ,fbaB,fdhE,fdhF,fdnH,fdoG,fdo b1093,b1094,b1123,b1129,b1130,b1131,b1185,b1188,b1189, H,fdoI,fdx,fic,flgB,flgC,flgD,flgE,flgF,flgH,focA,fol b1190,b1200,b1237,b1241,b1243,b1247,b1262,b1266,b1276, A,frdA,frdC,frdD,frsA,fruK,fsaB,ftnA,ftsH,ftsZ,fucI, b1279,b1297,b1304,b1305,b1306,b1313,b1329,b1388,b1389, fucU,fumB,fumC,fur,fusA,gadX,gapA,garD,garP,gcl, b1391,b1392,b1394,b1395,b1406,b1418,b1449,b1469,b1475, gcvP,gcvT,gip,glcA,glcB,gldA,glgS,glk,glnH,glnQ,gl b1479,b1513,b1530,b1531,b1535,b1539,b1584,b1587,b1588, pA,glpB,glpC,glpD,glpF,glpK,glpT,glpX,gltA,gltI,gl b1589,b1590,b1593,b1596,b1611,b1613,b1622,b1635,b1637, tJ,gltK,glxR,gntT,gntX,gpmI,gpr,groL,groS,grxC,gsh b1647,b1661,b1670,b1673,b1674,b1680,b1682,b1683,b1684, A,gspL,gst,gutM,gutQ,hcaR,hemB,hemC,hemG,hem b1702,b1713,b1717,b1719,b1723,b1724,b1743,b1748,b1765, H,hemL,hflC,hflK,hha,hisJ,hisQ,hldE,hns,holE,hscA b1770,b1778,b1779,b1780,b1794,b1805,b1814,b1818,b1819, ,htpG,htpX,hyaD,hybB,hybD,hybE,hybF,hybG,hybO b1823,b1826,b1829,b1831,b1833,b1841,b1842,b1863,b1887, ,hypB,hypC,hypD,hypE,icc,ilvM,inaA,kbl,kdpA,kef b1905,b1919,b2063,b2097,b2110,b2133,b2143,b2148,b2150, B,kgtP,lamB,lgt,lolA,lpd,lpxC,lpxD,lrhA,lsrA,lysA,l b2159,b2168,b2172,b2180,b2218,b2235,b2236,b2237,b2240, ysS,maeA,malE,malF,malG,malK,malM,malP,malQ, b2241,b2242,b2243,b2258,b2262,b2266,b2277,b2282,b2283, malY,manA,manY,manZ,marA,marR,mazG,mdaA,m b2284,b2286,b2287,b2288,b2289,b2293,b2294,b2296,b2297, elA,melB,menB,mglB,mglC,mgrB,mlaD,mlaE,mlaF, b2304,b2308,b2309,b2310,b2323,b2324,b2327,b2341,b2370, mnmC,mntR,mppA,msrB,mtgA,mtlR,mug,mukB,mu b2388,b2426,b2429,b2465,b2472,b2478,b2498,b2501,b2516, rG,murP,mutS,nagA,narU,nei,nfo,nrdB,nudH,nuoA, b2 2 b2 26 b2 3 b2 3 b2 63 b2 64 b2 2 b2 81 b2 8 CG G GO.0044281 small molecule 162 4.58E-06 b0034,b0048,b0090,b0103,b0114,b0115,b0116,b0118,b0180, aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,acs,adh metabolic process b0221,b0312,b0313,b0314,b0419,b0444,b0480,b0505,b0507, E,allA,allB,ansB,aroF,asd,aspA,astC,atpF,b4467,bet b0508,b0509,b0511,b0512,b0526,b0651,b0677,b0720,b0721, B,betI,betT,caiF,cdd,cfa,coaE,cydA,cysS,dadA,dadX b0722,b0723,b0724,b0726,b0727,b0728,b0729,b0733,b1014, ,dapA,dapE,dapF,dcyD,deoA,deoB,deoC,dgoK,dhaK b1062,b1092,b1093,b1094,b1131,b1189,b1190,b1200,b1241, ,dkgA,dld,eno,epd,fabB,fabD,fabG,fabR,fabZ,fadD,f b1262,b1276,b1297,b1388,b1389,b1391,b1392,b1394,b1469, adE,fadJ,fbaB,fdhF,folA,frdD,fumB,fumC,gapA,gar b1479,b1539,b1593,b1611,b1613,b1622,b1637,b1661,b1680, D,gcl,gcvP,gcvT,gip,glcB,gldA,glk,glpA,glpB,glpC, b1702,b1713,b1719,b1723,b1748,b1779,b1805,b1814,b1919, glpD,glpK,glpT,glpX,gltA,glxR,gntT,gntX,gpmI,gpr, b2097,b2133,b2143,b2172,b2235,b2240,b2241,b2242,b2243, grxC,gutQ,hldE,ilvM,kbl,lpd,lysA,lysS,maeA,malY, b2262,b2277,b2283,b2296,b2297,b2323,b2341,b2388,b2472, manA,menB,murG,nagA,narU,nrdB,nuoG,nuoM,paa b2478,b2498,b2501,b2563,b2564,b2601,b2708,b2744,b2779, A,paaB,paaD,paaE,paaG,pdxJ,pfkB,pgi,pheT,ppk,pp b2838,b2866,b2867,b2868,b2870,b2871,b2878,b2881,b2890, s,pta,purA,purB,putA,puuA,pyrC,queC,ridA,rihA,rpe b2903,b2905,b2907,b2914,b2927,b2957,b2976,b3001,b3012, ,rpiA,sdaA,sdhA,sdhB,sdhC,sdhD,selA,selB,sgaH,sp b3052,b3113,b3114,b3117,b3118,b3128,b3386,b3413,b3415, oT,sthA,sucA,sucB,sucC,sucD,sufS,surE,tdcA,tdcB,t b3426,b3433,b3590,b3591,b3610,b3612,b3617,b3650,b3693, dcE,tdcF,tdcG,thrS,tpiA,trpC,tyrS,ubiA,ubiC,ubiH,u b3736,b3769,b3809,b3834,b3919,b3925,b3926,b3945,b3962, pp,ushA,xdhA,xdhB,xdhC,xdhD,yajO,ybbW,ydfG,y b3963,b4015,b4025,b4039,b4040,b4069,b4079,b4122,b4139, eiQ,ygeW,ygeX,ygfK,yigP,ynfK b4151,b4177,b4196,b4243,b4381,b4382,b4383,b4467,b4471 GO.0044699 single-organism process 367 7.59E-06 b0034,b0048,b0065,b0090,b0095,b0096,b0098,b0103,b0114, aaeA,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,ac b0115,b0116,b0118,b0154,b0155,b0156,b0179,b0180,b0221, rA,acrB,acs,acuI,adhE,aec38,aec39,ahpC,ahpF,allA,a b0274,b0312,b0313,b0314,b0369,b0411,b0418,b0419,b0428, llB,alsA,ansB,arcA2,argT,arnF,aroF,artP,asd,aspA,as b0429,b0430,b0431,b0432,b0438,b0444,b0462,b0463,b0472, tC,atpF,atpI,b4467,bamD,betB,betI,betT,bfr,cadC,cai b0475,b0478,b0480,b0494,b0505,b0507,b0508,b0509,b0511, F,cdd,cfa,cheW,clcA,clpX,coaE,corC,crp,curA,cusC, b0512,b0526,b0572,b0605,b0606,b0621,b0651,b0653,b0654, cybB,cydA,cyoA,cyoB,cyoC,cyoD,cyoE,cysQ,cysS, b0655,b0658,b0677,b0698,b0714,b0720,b0721,b0722,b0723, dacB,dacC,dadA,dadX,dapA,dapE,dapF,dctA,dcuA, b0724,b0726,b0727,b0728,b0729,b0733,b0795,b0808,b0809, dcuB,dcuC,dcyD,deoA,deoB,deoC,dgoK,dhaK,dinD, b0811,b0812,b0839,b0851,b0852,b0864,b0891,b0894,b0895, dkgA,dld,dmsA,dmsB,dmsC,dppA,dppB,dps,dsbB,dt b0896,b0903,b0904,b0924,b0947,b1014,b1062,b1073,b1074, pB,ecfL,eno,epd,erpA,evgS,fabB,fabD,fabG,fabR,fa b1075,b1076,b1077,b1079,b1092,b1093,b1094,b1123,b1129, bZ,fadD,fadE,fadJ,fbaB,fdhF,fdnH,fdoG,fdoH,fdoI,f b1130,b1131,b1185,b1189,b1190,b1200,b1241,b1243,b1247, dx,flgB,flgC,flgD,flgE,flgF,flgH,focA,folA,frdA,frd b1262,b1276,b1279,b1297,b1313,b1329,b1388,b1389,b1391, C,frdD,fruK,fsaB,ftnA,ftsZ,fucI,fucU,fumB,fumC,ga b1392,b1394,b1395,b1406,b1418,b1449,b1469,b1475,b1479, pA,garD,garP,gcl,gcvP,gcvT,gip,glcA,glcB,gldA,glg b1513,b1539,b1587,b1588,b1589,b1590,b1593,b1596,b1611, S,glk,glnH,glnQ,glpA,glpB,glpC,glpD,glpF,glpK,glp b1613,b1622,b1637,b1647,b1661,b1670,b1673,b1674,b1680, T,glpX,gltA,gltI,gltJ,gltK,glxR,gntT,gntX,gpmI,gpr,g b1702,b1713,b1719,b1723,b1748,b1765,b1778,b1779,b1805, roL,groS,grxC,gutM,gutQ,hemB,hemC,hemG,hemH, b1814,b1818,b1819,b1863,b1887,b1905,b1919,b2063,b2097, hemL,hisJ,hisQ,hldE,hybB,hybO,ilvM,kbl,kdpA,kef b2110,b2133,b2143,b2148,b2150,b2159,b2168,b2172,b2180, B,kgtP,lamB,lolA,lpd,lpxC,lpxD,lsrA,lysA,lysS,mae b2218,b2235,b2236,b2240,b2241,b2242,b2243,b2258,b2262, A,malE,malF,malG,malK,malM,malP,malQ,malY,m b2277,b2282,b2283,b2284,b2286,b2287,b2288,b2296,b2297, anA,manY,manZ,mazG,mdaA,melA,melB,menB,mg b2308,b2309,b2310,b2323,b2324,b2341,b2370,b2388,b2426, lB,mglC,mlaD,mlaE,mlaF,mnmC,mppA,msrB,mtgA, b2429,b2472,b2478,b2498,b2501,b2525,b2563,b2564,b2587, mug,mukB,murG,murP,mutS,nagA,narU,nei,nfo,nrd b2595,b2601,b2679,b2706,b2707,b2708,b2733,b2744,b2779, B,nuoA,nuoB,nuoC,nuoF,nuoG,nuoH,nuoM,nupG,o b2781,b2802,b2804,b2838,b2866,b2867,b2868,b2869,b2870, mpR,oppA,oppF,paaA,paaB,paaD,paaE,paaG,paaH,p b2871,b2878,b2880,b2881,b2888,b2890,b2891,b2903,b2905, ck,pdxJ,pfkB,pflB,pgi,pgpA,pheT,phoP,phoQ,potD,p b2907,b2914,b2927,b2957,b2964,b2975,b2976,b2995,b2997, pk,pps,prfB,priB,proX,pta,ptsN,purA,purB,putA,puu b3001,b3012,b3035,b3040,b3049,b3052,b3068,b3087,b3095, A,pyrC,queC,rbsA,rbsD,rbsK,rcsC,recR,rfaG,rhaA,r b3113,b3114,b3116,b3117,b3118,b3127,b3128,b3160,b3182, haB,rhaD,rhaM,rhaR,rhaT,ridA,rihA,rimK,rpe,rpiA,r GO.0006412 translation 37 1.87E-05b3193 b0526,b0659,b0852,b1089,b1637,b1713,b1717,b1719,b2609, b3194 b319 b3204 b3208 b3241 b32 3 b3336 b33 0 cysS,fusA,lysS,pheT,prfB,rimK,rplA,rplB,rplC,rplD,l C d A dhA dh dhC dh A l b2890,b2891,b3186,b3231,b3296,b3298,b3299,b3309,b3313, rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX,rpmF,rpmI,r b3314,b3315,b3316,b3317,b3318,b3319,b3320,b3321,b3339, pmJ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL,rpsM,rpsP,rpsR,r b3340,b3341,b3342,b3590,b3591,b3983,b3984,b4200,b4202, psS,selA,selB,thrS,tufA,tyrS,ybeY GO.0016052 carbohydrate catabolic 39 2.76E-05 b0114,b0115,b0116,b0726,b1200,b1613,b1723,b1779,b2097, aceE,aceF,bcsZ,deoC,dgoK,dhaK,eno,fbaB,fruK,fucI process b2168,b2241,b2242,b2243,b2388,b2779,b2802,b3128,b3386, ,gapA,garD,gldA,glk,glpA,glpB,glpC,glpD,glpK,gnt b3415,b3416,b3417,b3426,b3531,b3612,b3693,b3748,b3752, T,gpmI,lpd,malP,malQ,manA,melA,pfkB,pgi,rbsD,rb b3901,b3902,b3903,b3904,b3919,b3926,b3945,b4025,b4119, sK,rhaA,rhaB,rhaD,rhaM,rpe,sgaH,sucA,tpiA,treC b4196,b4239,b4381 GO.0019752 carboxylic acid 104 3.96E-05 b0034,b0048,b0114,b0115,b0116,b0118,b0180,b0221,b0507, aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,acs,ans metabolic process b0508,b0509,b0526,b0677,b0720,b0721,b0722,b0723,b0724, B,aroF,asd,aspA,astC,b4467,caiF,cfa,cysS,dadA,dad b0726,b0727,b0728,b0729,b1014,b1092,b1093,b1094,b1189, X,dapA,dapE,dapF,dcyD,dgoK,dkgA,dld,eno,fabB,fa b1190,b1262,b1276,b1297,b1388,b1389,b1391,b1392,b1394, bD,fabG,fabR,fabZ,fadD,fadE,fadJ,fbaB,fdhF,folA,fr b1479,b1593,b1611,b1622,b1637,b1661,b1680,b1702,b1713, dD,fumB,fumC,gapA,garD,gcl,gcvP,gcvT,gip,glcB,g b1719,b1723,b1748,b1779,b1805,b1814,b1919,b2097,b2133, lk,gltA,glxR,gntT,gpmI,gutQ,ilvM,kbl,lpd,lysA,lysS, b2296,b2297,b2323,b2341,b2388,b2472,b2478,b2563,b2601, maeA,malY,nagA,paaA,paaB,paaD,paaE,paaG,pfkB, b2708,b2779,b2838,b2870,b2871,b2878,b2890,b2903,b2905, pgi,pheT,pps,pta,putA,puuA,ridA,sdaA,sdhA,sdhB,s b2957,b2976,b3012,b3113,b3114,b3117,b3118,b3128,b3415, dhC,sdhD,selA,selB,sgaH,sucA,sucB,sucC,sucD,suf b3433,b3590,b3591,b3612,b3617,b3693,b3769,b3809,b3834, S,tdcA,tdcB,tdcE,tdcF,tdcG,thrS,tpiA,trpC,tyrS,ubiC b3919,b3963,b4015,b4025,b4039,b4069,b4079,b4122,b4139, ,ygeW,ygeX,ygfK,yigP,ynfK b4151,b4196,b4243,b4467,b4471 GO.0044724 single-organism 37 5.60E-05 b0114,b0115,b0116,b0726,b1200,b1613,b1723,b1779,b2097, aceE,aceF,dgoK,dhaK,eno,fbaB,fruK,fucI,gapA,garD carbohydrate catabolic b2168,b2241,b2242,b2243,b2388,b2779,b2802,b3128,b3386, ,gldA,glk,glpA,glpB,glpC,glpD,glpK,gntT,gpmI,lpd, process b3415,b3416,b3417,b3426,b3612,b3693,b3748,b3752,b3901, malP,malQ,manA,melA,pfkB,pgi,rbsD,rbsK,rhaA,rh b3902,b3903,b3904,b3919,b3926,b3945,b4025,b4119,b4196, aB,rhaD,rhaM,rpe,sgaH,sucA,tpiA,treC GO.0044248 cellular catabolic 75 5.80E-05b4239 b0116,b0118,b0161,b0221,b0418,b0480,b0505,b0507,b0509, acnB,acs,allA,allB,astC,b4467,bcsZ,cdd,chpA,dacB, process b0512,b0651,b0677,b0727,b0947,b1014,b1084,b1189,b1200, dadA,dcyD,deaD,degP,degQ,deoB,deoC,dgoK,dhaK, b1388,b1389,b1391,b1392,b1394,b1395,b1539,b1635,b1748, dkgA,fadD,fadE,fadJ,garD,gcl,gcvP,gcvT,glcB,gldA, b1805,b1814,b1919,b2143,b2241,b2242,b2243,b2297,b2341, glpA,glpB,glpC,glpD,glpK,glxR,gntT,gntX,gst,kbl,lp b2744,b2782,b2830,b2866,b2867,b2868,b2871,b2881,b2903, d,malP,malQ,melA,nagA,nudH,paaA,paaB,paaD,paa b2905,b2976,b3012,b3113,b3114,b3117,b3118,b3128,b3162, E,paaG,paaH,pgpA,pta,putA,rihA,rne,rraB,sdaA,sga b3182,b3234,b3413,b3415,b3416,b3417,b3426,b3531,b3617, H,sucB,surE,tdcA,tdcB,tdcE,tdcF,tdcG,treC,ushA,xd b3693,b3926,b3945,b4069,b4119,b4196,b4239,b4255,b4381, hA,xdhB,xdhC,xdhD,ycbX,ydfG,ygeX b4383,b4467,b4471 GO.0043043 peptide biosynthetic 38 8.68E-05 b0526,b0659,b0852,b1089,b1637,b1713,b1717,b1719,b2609, cysS,fusA,gshA,lysS,pheT,prfB,rimK,rplA,rplB,rplC process b2688,b2890,b2891,b3186,b3231,b3296,b3298,b3299,b3309, ,rplD,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX,rpmF, b3313,b3314,b3315,b3316,b3317,b3318,b3319,b3320,b3321, rpmI,rpmJ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL,rpsM,rpsP, b3339,b3340,b3341,b3342,b3590,b3591,b3983,b3984,b4200, rpsR,rpsS,selA,selB,thrS,tufA,tyrS,ybeY b4202,b4203 GO.0032787 monocarboxylic acid 52 0.000101 b0034,b0114,b0115,b0116,b0118,b0180,b0221,b0507,b0508, aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,acs,b44 metabolic process b0509,b0726,b1092,b1093,b1094,b1276,b1388,b1389,b1391, 67,caiF,cfa,dgoK,dld,eno,fabB,fabD,fabG,fabR,fabZ, b1392,b1394,b1593,b1661,b1702,b1723,b1779,b1805,b2097, fadD,fadE,fadJ,fbaB,fdhF,gapA,gcl,gip,glcB,glk,glx b2133,b2296,b2297,b2323,b2341,b2388,b2563,b2779,b2976, R,gntT,gpmI,lpd,paaA,paaB,paaD,paaE,paaG,pfkB,p b3113,b3114,b3117,b3118,b3415,b3612,b3693,b3919,b3963, gi,pps,pta,sucA,tdcA,tdcB,tdcE,tdcF,tdcG,tpiA,ubiC, b4015,b4025,b4039,b4069,b4079,b4467,b4471 ynfK GO.0043436 oxoacid metabolic 106 0.000104 b0034,b0048,b0114,b0115,b0116,b0118,b0180,b0221,b0507, aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,acs,ans process b0508,b0509,b0526,b0677,b0720,b0721,b0722,b0723,b0724, B,aroF,asd,aspA,astC,b4467,caiF,cfa,cysS,dadA,dad b0726,b0727,b0728,b0729,b1014,b1092,b1093,b1094,b1189, X,dapA,dapE,dapF,dcyD,dgoK,dkgA,dld,eno,fabB,fa b1190,b1262,b1276,b1297,b1388,b1389,b1391,b1392,b1394, bD,fabG,fabR,fabZ,fadD,fadE,fadJ,fbaB,fdhF,folA,fr b1469,b1479,b1593,b1611,b1622,b1637,b1661,b1680,b1702, dD,fumB,fumC,gapA,garD,gcl,gcvP,gcvT,gip,glcB,g b1713,b1719,b1723,b1748,b1779,b1805,b1814,b1919,b2097, lk,gltA,glxR,gntT,gpmI,gutQ,ilvM,kbl,lpd,lysA,lysS, b2133,b2296,b2297,b2323,b2341,b2388,b2472,b2478,b2501, maeA,malY,nagA,narU,paaA,paaB,paaD,paaE,paaG, b2563,b2601,b2708,b2779,b2838,b2870,b2871,b2878,b2890, pfkB,pgi,pheT,ppk,pps,pta,putA,puuA,ridA,sdaA,sdh b2903,b2905,b2957,b2976,b3012,b3113,b3114,b3117,b3118, A,sdhB,sdhC,sdhD,selA,selB,sgaH,sucA,sucB,sucC, b3128,b3415,b3433,b3590,b3591,b3612,b3617,b3693,b3769, sucD,sufS,tdcA,tdcB,tdcE,tdcF,tdcG,thrS,tpiA,trpC,t b3809,b3834,b3919,b3963,b4015,b4025,b4039,b4069,b4079, yrS,ubiC,ygeW,ygeX,ygfK,yigP,ynfK b4122,b4139,b4151,b4196,b4243,b4467,b4471 GO.0019318 hexose metabolic 22 0.000378 b0903,b1479,b1613,b1702,b1779,b1814,b2168,b2802,b2804, epd,fruK,fsaB,fucI,fucU,gapA,glpX,gpmI,maeA,man process b2927,b3403,b3612,b3901,b3902,b3903,b3904,b3906,b3919, A,pck,pflB,pgi,pps,rhaA,rhaB,rhaD,rhaM,rhaR,sdaA, b3925,b3946,b4025,b4471 tdcG,tpiA GO.0005996 monosaccharide 30 0.000418 b0903,b1200,b1479,b1613,b1702,b1779,b1814,b2168,b2708, dhaK,dkgA,epd,fruK,fsaB,fucI,fucU,gapA,glpX,gpm metabolic process b2802,b2804,b2914,b2927,b3012,b3386,b3403,b3612,b3748, I,gutQ,maeA,manA,pck,pflB,pgi,pps,rbsD,rbsK,rhaA b3752,b3901,b3902,b3903,b3904,b3906,b3919,b3925,b3946, ,rhaB,rhaD,rhaM,rhaR,rpe,rpiA,sdaA,sgaH,tdcG,tpi b4025,b4196,b4471 A GO.0044237 cellular metabolic 331 0.000418 b0034,b0048,b0090,b0096,b0098,b0103,b0114,b0115,b0116, ECs3957,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acp process b0118,b0154,b0156,b0161,b0179,b0180,b0221,b0274,b0312, S,acs,aec38,aec39,allA,allB,ansB,arcA2,arnF,aroF,as b0313,b0314,b0369,b0418,b0419,b0428,b0429,b0430,b0431, d,aspA,astC,atpF,b2726,b4467,bcsZ,betB,betI,betT,c b0432,b0438,b0444,b0460,b0472,b0473,b0475,b0480,b0505, adC,caiF,cdd,cfa,chpA,clpX,coaE,crp,cspA,cspC,cus b0507,b0508,b0509,b0511,b0512,b0526,b0572,b0581,b0651, C,cybB,cydA,cyoA,cyoB,cyoC,cyoD,cyoE,cysQ,cys b0659,b0677,b0683,b0714,b0720,b0721,b0722,b0723,b0724, S,dacB,dacC,dadA,dadX,dapA,dapE,dapF,dcyD,dea b0726,b0727,b0728,b0729,b0733,b0796,b0817,b0839,b0852, D,degP,degQ,deoA,deoB,deoC,dgoK,dhaK,dkgA,dld b0894,b0895,b0896,b0903,b0924,b0947,b1014,b1062,b1084, ,dmsA,dmsB,dmsC,dnaG,dsbB,eno,epd,erpA,evgS,fa b1089,b1092,b1093,b1094,b1129,b1130,b1131,b1185,b1189, bB,fabD,fabG,fabR,fabZ,fadD,fadE,fadJ,fbaB,fdhF,f b1190,b1200,b1237,b1262,b1266,b1276,b1279,b1297,b1305, dnH,fdoG,fdoH,fdoI,folA,frdA,frdC,frdD,fruK,fumB b1306,b1388,b1389,b1391,b1392,b1394,b1418,b1469,b1475, ,fumC,fur,fusA,gadX,gapA,garD,gcl,gcvP,gcvT,gip,g b1479,b1530,b1531,b1539,b1584,b1587,b1588,b1589,b1590, lcB,gldA,glgS,glk,glpA,glpB,glpC,glpD,glpK,glpT,g b1593,b1611,b1613,b1622,b1635,b1637,b1661,b1670,b1680, lpX,gltA,glxR,gntT,gntX,gpmI,gpr,groL,groS,grxC,g b1702,b1713,b1717,b1719,b1723,b1724,b1743,b1748,b1770, shA,gst,gutM,gutQ,hcaR,hemB,hemC,hemG,hemH,h b1778,b1779,b1805,b1814,b1823,b1826,b1842,b1863,b1919, emL,hha,hldE,hns,holE,hscA,htpG,hybF,hypB,hypD, b2097,b2110,b2133,b2143,b2159,b2168,b2172,b2218,b2235, hypE,ilvM,kbl,lgt,lpd,lpxC,lpxD,lrhA,lysA,lysS,mae b2236,b2240,b2241,b2242,b2243,b2258,b2262,b2277,b2282, A,malP,malQ,malY,manA,marA,marR,melA,menB, b2283,b2284,b2287,b2289,b2293,b2296,b2297,b2323,b2324, mgrB,mnmC,mntR,msrB,mtgA,mtlR,mug,mukB,mur b2341,b2370,b2388,b2429,b2472,b2478,b2498,b2501,b2526, G,murP,mutS,nagA,narU,nei,nfo,nrdB,nudH,nuoB,n b2537,b2563,b2564,b2572,b2581,b2601,b2608,b2609,b2688, uoF,nuoG,nuoH,nuoM,ompR,paaA,paaB,paaD,paaE, b2706,b2707,b2708,b2726,b2727,b2729,b2730,b2733,b2744, paaG,pdxJ,pfkB,pflB,pgi,pgpA,pheT,phoP,phoQ,ppk b2779,b2782,b2806,b2828,b2830,b2838,b2866,b2867,b2868, ,pps,prfB,priB,pspB,pspC,pta,ptsN,purA,purB,putA, b2869,b2870,b2871,b2878,b2881,b2890,b2891,b2903,b2905, puuA,pyrC,queC,rbsK,rcsC,recR,rfaG,rhaB,rhaR,rid b2907,b2914,b2927,b2957,b2960,b2976,b2991,b3001,b3012, A,rihA,rimK,rimM,rlmE,rlmM,rne,rpe,rpiA,rplA,rpl b3049,b3052,b3066,b3068,b3075,b3113,b3114,b3117,b3118, B,rplC,rplD,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX b3128,b3155,b3162,b3179,b3182,b3186,b3204,b3208,b3231, ,rpmF,rpmI,rpmJ,rpoH,rpoZ,rpsC,rpsD,rpsF,rpsG,rps b3234,b3296,b3298,b3299,b3309,b3313,b3314,b3315,b3316, J,rpsL,rpsM,rpsP,rpsR,rpsS,rraB,rseA,ruvC,sdaA,sdh b3317,b3318,b3319,b3320,b3321,b3339,b3340,b3341,b3342, A,sdhB,sdhC,sdhD,secA,selA,selB,sgaH,soxS,speG, b3357,b3386,b3405,b3413,b3415,b3416,b3417,b3426,b3433, spoT,spy,srlR,sthA,sucA,sucB,sucC,sucD,sufS,surE, b3461 b3 16 b3 31 b3 6 b3 3 b3 90 b3 91 b3601 b3610 dAd d d dGhS iA C GO.0044763 single-organism cellular 311 0.000588 b0034,b0048,b0065,b0090,b0095,b0096,b0098,b0103,b0114, aaeA,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acpS,ac process b0115,b0116,b0118,b0154,b0155,b0156,b0179,b0180,b0221, rA,acrB,acs,aec38,aec39,ahpC,ahpF,allA,allB,alsA,a b0274,b0312,b0313,b0314,b0369,b0411,b0418,b0419,b0428, nsB,arcA2,arnF,aroF,artP,asd,aspA,astC,atpF,b4467, b0429,b0430,b0431,b0432,b0438,b0444,b0462,b0463,b0472, bamD,betB,betI,betT,bfr,cadC,caiF,cdd,cfa,cheW,clc b0475,b0478,b0480,b0505,b0507,b0508,b0509,b0511,b0512, A,clpX,coaE,crp,cusC,cybB,cydA,cyoA,cyoB,cyoC, b0526,b0572,b0605,b0606,b0621,b0651,b0677,b0698,b0714, cyoD,cyoE,cysQ,cysS,dacB,dacC,dadA,dadX,dapA,d b0720,b0721,b0722,b0723,b0724,b0726,b0727,b0728,b0729, apE,dapF,dctA,dcuA,dcuB,dcuC,dcyD,deoA,deoB,d b0733,b0795,b0808,b0809,b0812,b0839,b0852,b0864,b0891, eoC,dgoK,dhaK,dinD,dkgA,dld,dmsA,dmsB,dmsC,d b0894,b0895,b0896,b0903,b0904,b0924,b0947,b1014,b1062, ppA,dps,dsbB,dtpB,ecfL,eno,epd,erpA,evgS,fabB,fa b1073,b1074,b1075,b1076,b1077,b1079,b1092,b1093,b1094, bD,fabG,fabR,fabZ,fadD,fadE,fadJ,fbaB,fdhF,fdnH,f b1123,b1129,b1130,b1131,b1185,b1189,b1190,b1200,b1243, doG,fdoH,fdoI,flgB,flgC,flgD,flgE,flgF,flgH,focA,fo b1262,b1276,b1279,b1297,b1329,b1388,b1389,b1391,b1392, lA,frdA,frdC,frdD,ftnA,ftsZ,fumB,fumC,gapA,garD, b1394,b1418,b1469,b1475,b1479,b1513,b1539,b1587,b1588, garP,gcl,gcvP,gcvT,gip,glcA,glcB,gldA,glgS,glk,gln b1589,b1590,b1593,b1596,b1611,b1613,b1622,b1637,b1661, Q,glpA,glpB,glpC,glpD,glpF,glpK,glpT,glpX,gltA,gl b1670,b1680,b1702,b1713,b1719,b1723,b1748,b1779,b1805, xR,gntT,gntX,gpmI,gpr,groL,groS,grxC,gutQ,hemB, b1814,b1818,b1819,b1863,b1887,b1905,b1919,b2097,b2110, hemC,hemG,hemH,hemL,hisQ,hldE,ilvM,kbl,kdpA, b2133,b2143,b2159,b2172,b2180,b2218,b2235,b2240,b2241, kefB,kgtP,lamB,lolA,lpd,lpxC,lpxD,lsrA,lysA,lysS, b2242,b2243,b2258,b2262,b2277,b2282,b2283,b2284,b2287, maeA,malE,malF,malG,malK,malP,malQ,malY,man b2296,b2297,b2308,b2323,b2341,b2370,b2388,b2429,b2472, A,manY,manZ,mazG,melA,melB,menB,mppA,mtgA b2478,b2498,b2501,b2563,b2564,b2587,b2595,b2601,b2708, ,mug,mukB,murG,murP,mutS,nagA,narU,nei,nfo,nrd b2733,b2744,b2779,b2781,b2838,b2866,b2867,b2868,b2869, B,nuoB,nuoF,nuoG,nuoH,nuoM,nupG,ompR,oppA,p b2870,b2871,b2878,b2881,b2888,b2890,b2891,b2903,b2905, aaA,paaB,paaD,paaE,paaG,pdxJ,pfkB,pflB,pgi,pgpA b2907,b2914,b2927,b2957,b2964,b2975,b2976,b3001,b3012, ,pheT,phoP,phoQ,potD,ppk,pps,prfB,priB,pta,ptsN,p b3035,b3040,b3049,b3052,b3068,b3095,b3113,b3114,b3116, urA,purB,putA,puuA,pyrC,queC,rbsA,rcsC,recR,rfa b3117,b3118,b3127,b3128,b3182,b3204,b3208,b3241,b3336, G,rhaT,ridA,rihA,rimK,rpe,rpiA,rplK,rpoH,ruvC,sda b3350,b3357,b3386,b3405,b3413,b3415,b3416,b3417,b3426, A,sdhA,sdhB,sdhC,sdhD,secA,selA,selB,sgaH,spoT, b3433,b3451,b3461,b3496,b3528,b3544,b3573,b3590,b3591, sthA,sucA,sucB,sucC,sucD,sufS,surE,tatB,tdcA,tdcB b3610,b3612,b3617,b3631,b3645,b3650,b3666,b3693,b3736, ,tdcC,tdcE,tdcF,tdcG,thrS,tolC,tpiA,treB,treC,trpC,ts b3749,b3769,b3805,b3809,b3834,b3838,b3850,b3892,b3893, x,tyrS,uacT,ubiA,ubiC,ubiH,ugpE,uhpT,upp,ushA,xd GO.0006096 glycolytic process 12 0.00067b3894 b0114,b0115,b0116,b0726,b1723,b1779,b2097,b2388,b2779, b3907 b3919 b3925 b3926 b3927 b3945 b3962 b3963 hAaceE,aceF,eno,fbaB,gapA,glk,gpmI,lpd,pfkB,pgi,suc dhB dhC dhD lE bI jO b L bbW b b3612,b3919,b4025 A,tpiA GO.1901564 organonitrogen 135 0.000717 b0048,b0090,b0103,b0114,b0115,b0116,b0154,b0312,b0313, aceE,aceF,allA,allB,amiD,ansB,aroF,asd,aspA,astC,a compound metabolic b0314,b0369,b0419,b0428,b0444,b0475,b0505,b0509,b0511, tpF,betB,betI,betT,cdd,coaE,cydA,cyoE,cysS,dacB,d process b0512,b0526,b0581,b0651,b0659,b0726,b0727,b0733,b0839, acC,dadA,dadX,dapA,dapE,dapF,dcyD,deoA,eno,ep b0852,b0867,b0920,b1014,b1062,b1089,b1093,b1131,b1189, d,fabG,fbaB,folA,fusA,gapA,gcvP,gcvT,glk,glxR,gnt b1190,b1262,b1297,b1539,b1584,b1593,b1622,b1637,b1680, X,gpmI,gshA,hemB,hemC,hemG,hemH,hemL,ilvM, b1713,b1717,b1719,b1723,b1748,b1779,b1814,b1919,b2097, kbl,lpd,lysA,lysS,malY,mtgA,murG,nuoG,nuoM,pdx b2143,b2277,b2283,b2297,b2388,b2472,b2478,b2498,b2564, J,pfkB,pgi,pheT,prfB,pta,purA,purB,putA,puuA,pyr b2601,b2609,b2688,b2744,b2779,b2838,b2866,b2867,b2868, C,queC,ridA,rihA,rimK,rpe,rpiA,rplA,rplB,rplC,rplD b2870,b2871,b2878,b2881,b2890,b2891,b2903,b2905,b2914, ,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX,rpmF,rpmI, b2927,b2957,b3113,b3114,b3117,b3118,b3182,b3186,b3208, rpmJ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL,rpsM,rpsP,rpsR, b3231,b3296,b3298,b3299,b3309,b3313,b3314,b3315,b3316, rpsS,sdaA,selA,selB,sgaH,speG,spoT,sthA,sucA,suc b3317,b3318,b3319,b3320,b3321,b3339,b3340,b3341,b3342, B,sufS,surE,tdcA,tdcB,tdcE,tdcF,tdcG,thrS,tpiA,trpC b3386,b3413,b3433,b3590,b3591,b3612,b3617,b3650,b3736, ,tufA,tyrS,upp,xdhA,xdhB,xdhC,xdhD,yajO,ybbW,y b3769,b3805,b3809,b3850,b3919,b3962,b3983,b3984,b4025, bdK,ybeY,ycbC,ydfG,ygeW,ygeX,ygfK,ynfK b4139,b4177,b4196,b4200,b4202,b4203,b4243,b4382,b4471 GO.0009987 cellular process 420 0.00119 b0034,b0048,b0065,b0090,b0095,b0096,b0098,b0103,b0114, ECs3957,aaeA,aceA,aceE,aceF,ackA,acnA,acnB,acp b0115,b0116,b0118,b0154,b0155,b0156,b0161,b0179,b0180, P,acpS,acrA,acrB,acs,aec38,aec39,ahpC,ahpF,allA,al b0221,b0274,b0312,b0313,b0314,b0369,b0411,b0418,b0419, lB,alsA,amiD,ansB,arcA2,arnF,aroF,artP,asd,aspA,as b0428,b0429,b0430,b0431,b0432,b0438,b0444,b0460,b0462, tC,atpF,b2726,b4467,bamD,bcsZ,betB,betI,betT,bfr, b0463,b0472,b0473,b0475,b0478,b0480,b0505,b0507,b0508, cadC,caiF,cdd,cfa,cheW,chpA,clcA,clpX,coaE,crp,cs b0509,b0511,b0512,b0526,b0572,b0581,b0605,b0606,b0621, pA,cspC,cusC,cybB,cydA,cyoA,cyoB,cyoC,cyoD,cy b0651,b0659,b0677,b0683,b0698,b0714,b0720,b0721,b0722, oE,cysQ,cysS,dacB,dacC,dadA,dadX,dapA,dapE,dap b0723,b0724,b0726,b0727,b0728,b0729,b0733,b0795,b0796, F,dctA,dcuA,dcuB,dcuC,dcyD,deaD,degP,degQ,deo b0808,b0809,b0812,b0817,b0839,b0852,b0864,b0867,b0877, A,deoB,deoC,dgoK,dhaK,dinD,dkgA,dld,dmsA,dms b0891,b0894,b0895,b0896,b0903,b0904,b0920,b0924,b0947, B,dmsC,dnaG,dppA,dps,dsbB,dtpB,ecfL,elaB,eno,ep b1014,b1062,b1073,b1074,b1075,b1076,b1077,b1079,b1084, d,erpA,evgS,fabB,fabD,fabG,fabR,fabZ,fadD,fadE,fa b1089,b1092,b1093,b1094,b1123,b1129,b1130,b1131,b1185, dJ,fbaB,fdhF,fdnH,fdoG,fdoH,fdoI,fdx,flgB,flgC,flg b1188,b1189,b1190,b1200,b1237,b1243,b1262,b1266,b1276, D,flgE,flgF,flgH,focA,folA,frdA,frdC,frdD,fruK,ftn b1279,b1297,b1305,b1306,b1329,b1388,b1389,b1391,b1392, A,ftsZ,fumB,fumC,fur,fusA,gadX,gapA,garD,garP,g b1394,b1418,b1469,b1475,b1479,b1513,b1530,b1531,b1535, cl,gcvP,gcvT,gip,glcA,glcB,gldA,glgS,glk,glnQ,glpA b1539,b1584,b1587,b1588,b1589,b1590,b1593,b1596,b1611, ,glpB,glpC,glpD,glpF,glpK,glpT,glpX,gltA,glxR,gnt b1613,b1622,b1635,b1637,b1661,b1670,b1680,b1682,b1683, T,gntX,gpmI,gpr,groL,groS,grxC,gshA,gst,gutM,gut b1684,b1702,b1713,b1717,b1719,b1723,b1724,b1743,b1748, Q,hcaR,hemB,hemC,hemG,hemH,hemL,hha,hisQ,hl b1770,b1778,b1779,b1780,b1805,b1814,b1818,b1819,b1823, dE,hns,holE,hscA,htpG,hybF,hybG,hypB,hypD,hypE b1826,b1831,b1842,b1863,b1887,b1905,b1919,b2097,b2110, ,ilvM,kbl,kdpA,kefB,kgtP,lamB,lgt,lolA,lpd,lpxC,lpx b2133,b2143,b2148,b2159,b2168,b2172,b2180,b2218,b2235, D,lrhA,lsrA,lysA,lysS,maeA,malE,malF,malG,malK, b2236,b2240,b2241,b2242,b2243,b2258,b2262,b2266,b2277, malP,malQ,malY,manA,manY,manZ,marA,marR,ma b2282,b2283,b2284,b2287,b2289,b2293,b2294,b2296,b2297, zG,melA,melB,menB,mglC,mgrB,mnmC,mntR,mpp b2308,b2323,b2324,b2341,b2370,b2388,b2429,b2472,b2478, A,msrB,mtgA,mtlR,mug,mukB,murG,murP,mutS,na b2498,b2501,b2525,b2526,b2537,b2563,b2564,b2572,b2581, gA,narU,nei,nfo,nrdB,nudH,nuoB,nuoF,nuoG,nuoH, b2587,b2595,b2601,b2608,b2609,b2679,b2688,b2706,b2707, nuoM,nupG,ompR,oppA,paaA,paaB,paaD,paaE,paa b2708,b2726,b2727,b2729,b2730,b2733,b2744,b2779,b2781, G,pdxJ,pfkB,pflB,pgi,pgpA,pheT,phoP,phoQ,potD,p b2782,b2806,b2828,b2830,b2838,b2866,b2867,b2868,b2869, pk,pps,prfB,priB,proQ,proX,pspB,pspC,pta,ptsN,pur b2870,b2871,b2878,b2881,b2888,b2890,b2891,b2899,b2903, A,purB,putA,puuA,pyrC,queC,rbsA,rbsK,rcsC,recR, GO.0043604 amide biosynthetic 42 0.00119b290 b0048,b0526,b0659,b0852,b1089,b1093,b1593,b1637,b1713, b290 b2914 b292 b29 b2960 b2964 b29 b29 6 cysS,fabG,folA,fusA,gshA,lysS,pheT,prfB,rimK,rplf G h h h idA ihA i i l l process b1717,b1719,b2609,b2688,b2870,b2890,b2891,b3186,b3231, A,rplB,rplC,rplD,rplI,rplK,rplM,rplP,rplU,rplV,rplW b3296,b3298,b3299,b3309,b3313,b3314,b3315,b3316,b3317, ,rplX,rpmF,rpmI,rpmJ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL b3318,b3319,b3320,b3321,b3339,b3340,b3341,b3342,b3590, ,rpsM,rpsP,rpsR,rpsS,selA,selB,thrS,tufA,tyrS,ybeY, b3591,b3983,b3984,b4200,b4202,b4203 ygeW,ynfK GO.0009061 anaerobic respiration 18 0.00126 b0156,b0894,b0895,b0896,b0903,b1276,b1475,b1587,b1588, acnA,dmsA,dmsB,dmsC,erpA,fdnH,fdoG,fdoH,fdoI, b1589,b1590,b3573,b3892,b3893,b3894,b4151,b4152,b4154 frdA,frdC,frdD,pflB,yiaI,ynfE,ynfF,ynfG,ynfH GO.0006631 fatty acid metabolic 20 0.00151 b0118,b0180,b0221,b1092,b1093,b1094,b1395,b1661,b1805, ackA,acnB,acpP,acpS,cfa,fabB,fabD,fabG,fabR,fabZ process b2296,b2297,b2323,b2341,b2563,b3113,b3114,b3117,b3118, ,fadD,fadE,fadJ,paaH,pta,tdcA,tdcB,tdcE,tdcF,tdcG b3963,b4471 GO.0009116 nucleoside metabolic 32 0.00155 b0103,b0114,b0115,b0116,b0444,b0651,b0726,b0733,b1062, aceE,aceF,atpF,cdd,coaE,cydA,deoA,eno,fbaB,gapA, process b1131,b1723,b1779,b2097,b2143,b2277,b2283,b2388,b2498, glk,gntX,gpmI,lpd,nuoG,nuoM,pfkB,pgi,purA,purB, b2744,b2779,b2866,b2867,b2868,b2881,b3413,b3612,b3650, pyrC,queC,rihA,spoT,sucA,surE,tpiA,upp,xdhA,xdh b3736,b3919,b4025,b4177,b4382 B,xdhC,xdhD GO.0019563 glycerol catabolic 7 0.00165 b1200,b2241,b2242,b2243,b3426,b3926,b3945 dhaK,gldA,glpA,glpB,glpC,glpD,glpK process GO.0022900 electron transport chain 16 0.00218 b0429,b0430,b0431,b0432,b0723,b0733,b0896,b1185,b1418, cybB,cydA,cyoA,cyoB,cyoC,cyoD,dmsC,dsbB,fdoI,f b1590,b1670,b2243,b2277,b2283,b3892,b4154 rdA,glpC,nuoG,nuoM,sdhA,ydhU,ynfH GO.0043603 cellular amide 46 0.00248 b0048,b0505,b0509,b0512,b0526,b0659,b0852,b1089,b1093, allA,allB,ansB,cysS,fabG,folA,fusA,glxR,gshA,lysS, metabolic process b1593,b1637,b1713,b1717,b1719,b2609,b2688,b2870,b2890, pheT,prfB,rimK,rplA,rplB,rplC,rplD,rplI,rplK,rplM,r b2891,b2957,b3186,b3231,b3296,b3298,b3299,b3309,b3313, plP,rplU,rplV,rplW,rplX,rpmF,rpmI,rpmJ,rpsC,rpsD, b3314,b3315,b3316,b3317,b3318,b3319,b3320,b3321,b3339, rpsF,rpsG,rpsJ,rpsL,rpsM,rpsP,rpsR,rpsS,selA,selB,t b3340,b3341,b3342,b3590,b3591,b3983,b3984,b4200,b4202, hrS,tufA,tyrS,ybeY,ygeW,ynfK GO.0070689 L-threonine catabolic 6 0.00248 b2297,b3113,b3114,b3117,b3118,b4471b4203 pta,tdcA,tdcB,tdcE,tdcF,tdcG process to propionate GO.0009119 ribonucleoside 30 0.0026 b0103,b0114,b0115,b0116,b0444,b0651,b0726,b0733,b1062, aceE,aceF,atpF,cdd,coaE,cydA,eno,fbaB,gapA,glk,gp metabolic process b1131,b1723,b1779,b2097,b2143,b2277,b2283,b2388,b2498, mI,lpd,nuoG,nuoM,pfkB,pgi,purA,purB,pyrC,queC,r b2744,b2779,b2866,b2867,b2868,b2881,b3612,b3650,b3736, ihA,spoT,sucA,surE,tpiA,upp,xdhA,xdhB,xdhC,xdh b3919,b4025,b4177 D GO.0009132 nucleoside diphosphate 13 0.0026 b0114,b0115,b0116,b0726,b1723,b1779,b2097,b2235,b2388, aceE,aceF,eno,fbaB,gapA,glk,gpmI,lpd,nrdB,pfkB,pg metabolic process b2779,b3612,b3919,b4025 i,sucA,tpiA GO.0071704 organic substance 325 0.0026 b0034,b0048,b0090,b0096,b0098,b0103,b0114,b0115,b0116, ECs3957,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acp metabolic process b0118,b0154,b0156,b0161,b0179,b0180,b0221,b0274,b0312, S,acs,adhE,aec38,aec39,agaS,allA,allB,amiD,ansB,ar b0313,b0314,b0369,b0418,b0419,b0428,b0438,b0444,b0460, cA2,arnF,aroF,asd,aspA,astC,atpF,b2726,b4467,bcsZ b0472,b0473,b0475,b0480,b0494,b0505,b0507,b0508,b0509, ,betB,betI,betT,cadC,caiF,cdd,cfa,chpA,clpB,clpX,co b0511,b0512,b0526,b0572,b0581,b0651,b0659,b0677,b0683, aE,crp,cspA,cspC,cusC,cydA,cyoE,cysQ,cysS,dacB, b0714,b0720,b0721,b0722,b0723,b0724,b0726,b0727,b0728, dacC,dadA,dadX,dapA,dapE,dapF,dcyD,deaD,degP, b0729,b0733,b0796,b0817,b0839,b0852,b0867,b0903,b0920, degQ,deoA,deoB,deoC,dgoK,dhaK,dkgA,dld,dnaG,e b0924,b0975,b1014,b1062,b1084,b1089,b1092,b1093,b1094, no,epd,erpA,evgS,fabB,fabD,fabG,fabR,fabZ,fadD,fa b1129,b1130,b1131,b1189,b1190,b1200,b1237,b1241,b1262, dE,fadJ,fbaB,fdhE,fdhF,folA,frdD,fruK,fsaB,ftsH,fu b1266,b1276,b1279,b1297,b1305,b1306,b1388,b1389,b1391, cI,fucU,fumB,fumC,fur,fusA,gadX,gapA,garD,gcl,gc b1392,b1394,b1469,b1479,b1530,b1531,b1539,b1584,b1593, vP,gcvT,gip,glcB,gldA,glgS,glk,glpA,glpB,glpC,glp b1611,b1613,b1622,b1637,b1661,b1680,b1702,b1713,b1717, D,glpK,glpT,glpX,gltA,glxR,gntT,gntX,gpmI,gpr,gro b1719,b1723,b1724,b1743,b1748,b1770,b1778,b1779,b1780, L,groS,grxC,gshA,gutM,gutQ,hcaR,hemB,hemC,he b1805,b1814,b1823,b1826,b1829,b1842,b1863,b1919,b2097, mG,hemH,hemL,hha,hldE,hns,holE,hscA,htpG,htpX, b2110,b2133,b2143,b2159,b2168,b2172,b2218,b2235,b2236, hyaD,hybD,hybE,hybF,hypB,hypC,hypD,hypE,iadA, b2240,b2241,b2242,b2243,b2258,b2262,b2277,b2283,b2289, ilvM,kbl,lgt,lpd,lpxC,lpxD,lrhA,lysA,lysS,maeA,mal b2296,b2297,b2323,b2324,b2341,b2370,b2388,b2472,b2478, P,malQ,malY,manA,marA,marR,melA,menB,mgrB, b2498,b2501,b2526,b2537,b2563,b2564,b2572,b2581,b2592, mnmC,mntR,msrB,mtgA,mtlR,mug,mukB,murG,mut b2601,b2608,b2609,b2688,b2706,b2707,b2708,b2726,b2727, S,nagA,narU,nei,nfo,nrdB,nudH,nuoG,nuoM,ompR, b2728,b2729,b2730,b2733,b2744,b2779,b2782,b2802,b2804, paaA,paaB,paaD,paaE,paaG,pck,pdxJ,pfkB,pflB,pgi, b2806,b2828,b2830,b2838,b2866,b2867,b2868,b2869,b2870, pgpA,pheT,phoP,phoQ,ppk,pps,prfB,priB,pspB,pspC b2871,b2872,b2878,b2881,b2890,b2891,b2903,b2905,b2907, ,pta,purA,purB,putA,puuA,pyrC,queC,rbsD,rbsK,rcs b2914,b2927,b2957,b2960,b2976,b2991,b2992,b2993,b3001, C,recR,rfaG,rhaA,rhaB,rhaD,rhaM,rhaR,ridA,rihA,ri b3012,b3049,b3052,b3066,b3068,b3075,b3113,b3114,b3117, mK,rimM,rlmE,rlmM,rne,rpe,rpiA,rplA,rplB,rplC,rpl b3118,b3128,b3136,b3155,b3162,b3178,b3179,b3182,b3186, D,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX,rpmF,rp b3208,b3231,b3234,b3296,b3298,b3299,b3309,b3313,b3314, mI,rpmJ,rpoH,rpoZ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL,rp b3315,b3316,b3317,b3318,b3319,b3320,b3321,b3339,b3340, sM,rpsP,rpsR,rpsS,rraB,rseA,ruvC,sdaA,sdhA,sdhB, b3341,b3342,b3357,b3386,b3403,b3405,b3413,b3415,b3416, sdhC,sdhD,secA,selA,selB,sgaH,soxS,speG,spoT,sp b3417,b3426,b3433,b3461,b3516,b3531,b3556,b3590,b3591, y,srlR,sthA,sucA,sucB,sucC,sucD,sufS,surE,tdcA,tdc GO.0015768 maltose transport 5 0.00263b3601 b4032,b4033,b4034,b4035,b4036 b3610 b3612 b361 b3631 b3649 b36 0 b3693 b3 36 lamB,malE,malF,malG,malKdddGAhSiAC C GO.0044723 single-organism 67 0.00263 b0090,b0096,b0114,b0115,b0116,b0118,b0179,b0180,b0726, aceA,aceE,aceF,acnA,acnB,acpP,arnF,dgoK,dhaK,dk carbohydrate metabolic b0903,b1094,b1200,b1276,b1279,b1479,b1613,b1702,b1723, gA,eno,epd,fabZ,fbaB,fruK,fsaB,fucI,fucU,gapA,gar process b1779,b1814,b2097,b2168,b2172,b2240,b2241,b2242,b2243, D,glcB,gldA,glgS,glk,glpA,glpB,glpC,glpD,glpK,glp b2258,b2388,b2708,b2779,b2802,b2804,b2914,b2927,b2976, T,glpX,gntT,gpmI,gutQ,hldE,lpd,lpxC,lpxD,maeA,m b3012,b3049,b3052,b3128,b3386,b3403,b3415,b3416,b3417, alP,malQ,manA,melA,murG,pck,pfkB,pflB,pgi,pps,r b3426,b3612,b3631,b3693,b3748,b3752,b3901,b3902,b3903, bsD,rbsK,rfaG,rhaA,rhaB,rhaD,rhaM,rhaR,rpe,rpiA,s b3904,b3906,b3919,b3925,b3926,b3945,b3946,b4015,b4025, daA,sgaH,sucA,tdcG,tpiA,treC,yciS,yeiQ b4119,b4196,b4239,b4471 GO.0046364 monosaccharide 10 0.00346 b1479,b1702,b1814,b2708,b3012,b3403,b3919,b3925,b4025, dkgA,glpX,gutQ,maeA,pck,pgi,pps,sdaA,tdcG,tpiA biosynthetic process b4471 GO.0006567 threonine catabolic 7 0.00388 b2297,b3113,b3114,b3117,b3118,b3617,b4471 kbl,pta,tdcA,tdcB,tdcE,tdcF,tdcG process GO.0006094 gluconeogenesis 8 0.00422 b1479,b1702,b1814,b3403,b3919,b3925,b4025,b4471 glpX,maeA,pck,pgi,pps,sdaA,tdcG,tpiA GO.0046128 purine ribonucleoside 24 0.00455 b0103,b0114,b0115,b0116,b0726,b0733,b1131,b1723,b1779, aceE,aceF,atpF,coaE,cydA,eno,fbaB,gapA,glk,gpmI,l metabolic process b2097,b2277,b2283,b2388,b2779,b2866,b2867,b2868,b2881, pd,nuoG,nuoM,pfkB,pgi,purA,purB,spoT,sucA,tpiA, b3612,b3650,b3736,b3919,b4025,b4177 xdhA,xdhB,xdhC,xdhD GO.0042278 purine nucleoside 25 0.00466 b0103,b0114,b0115,b0116,b0651,b0726,b0733,b1131,b1723, aceE,aceF,atpF,coaE,cydA,eno,fbaB,gapA,glk,gpmI,l metabolic process b1779,b2097,b2277,b2283,b2388,b2779,b2866,b2867,b2868, pd,nuoG,nuoM,pfkB,pgi,purA,purB,rihA,spoT,sucA, b2881,b3612,b3650,b3736,b3919,b4025,b4177 tpiA,xdhA,xdhB,xdhC,xdhD GO.1901606 alpha-amino acid 16 0.00471 b0116,b0727,b1014,b1189,b1748,b1814,b1919,b2297,b2903, astC,dadA,dcyD,gcvP,gcvT,kbl,lpd,pta,putA,sdaA,su catabolic process b2905,b3113,b3114,b3117,b3118,b3617,b4471 cB,tdcA,tdcB,tdcE,tdcF,tdcG GO.0006090 pyruvate metabolic 14 0.00508 b0114,b0115,b0116,b0726,b1702,b1723,b1779,b2097,b2388, aceE,aceF,eno,fbaB,gapA,glk,gpmI,lpd,pfkB,pgi,pps, process b2779,b3612,b3919,b4025,b4039 sucA,tpiA,ubiC GO.0044282 small molecule 45 0.00615 b0116,b0118,b0221,b0507,b0509,b0677,b0727,b1014,b1189, acnB,acs,astC,b4467,dadA,dcyD,dgoK,dhaK,dkgA,f catabolic process b1200,b1388,b1389,b1391,b1392,b1394,b1395,b1748,b1805, adD,fadE,fadJ,garD,gcl,gcvP,gcvT,glcB,gldA,glpA,g b1814,b1919,b2241,b2242,b2243,b2297,b2341,b2871,b2903, lpB,glpC,glpD,glpK,glxR,gntT,kbl,lpd,nagA,paaA,p b2905,b2976,b3012,b3113,b3114,b3117,b3118,b3128,b3415, aaB,paaD,paaE,paaG,paaH,pta,putA,sdaA,sgaH,sucB b3426,b3617,b3693,b3926,b3945,b4069,b4196,b4467,b4471 ,tdcA,tdcB,tdcE,tdcF,tdcG,ygeX GO.0046395 carboxylic acid 37 0.00661 b0116,b0118,b0221,b0507,b0509,b0677,b0727,b1014,b1189, acnB,acs,astC,b4467,dadA,dcyD,dgoK,fadD,fadE,fa catabolic process b1388,b1389,b1391,b1392,b1394,b1395,b1748,b1805,b1814, dJ,garD,gcl,gcvP,gcvT,glcB,glxR,gntT,kbl,lpd,nagA, b1919,b2297,b2341,b2871,b2903,b2905,b2976,b3113,b3114, paaA,paaB,paaD,paaE,paaG,paaH,pta,putA,sdaA,sga b3117,b3118,b3128,b3415,b3617,b3693,b4069,b4196,b4467, H,sucB,tdcA,tdcB,tdcE,tdcF,tdcG,ygeX GO.0006006 glucose metabolic 12 0.0068 b0903,b1479,b1702,b1779,b1814,b2927,b3403,b3612,b3919,b4471 epd,gapA,glpX,gpmI,maeA,pck,pflB,pgi,pps,sdaA,td process b3925,b4025,b4471 cG,tpiA GO.0009068 aspartate family amino 8 0.00737 b0727,b2297,b3113,b3114,b3117,b3118,b3617,b4471 kbl,pta,sucB,tdcA,tdcB,tdcE,tdcF,tdcG acid catabolic process GO.0019541 propionate metabolic 8 0.00737 b0118,b2296,b2297,b3113,b3114,b3117,b3118,b4471 ackA,acnB,pta,tdcA,tdcB,tdcE,tdcF,tdcG process GO.0015766 disaccharide transport 7 0.00761 b4032,b4033,b4034,b4035,b4036,b4120,b4240 lamB,malE,malF,malG,malK,melB,treB GO.0046034 ATP metabolic process 16 0.00764 b0114,b0115,b0116,b0726,b0733,b1723,b1779,b2097,b2277, aceE,aceF,atpF,cydA,eno,fbaB,gapA,glk,gpmI,lpd,nu b2283,b2388,b2779,b3612,b3736,b3919,b4025 oG,nuoM,pfkB,pgi,sucA,tpiA GO.0044238 primary metabolic 289 0.00862 b0034,b0048,b0090,b0096,b0098,b0103,b0114,b0115,b0116, ECs3957,aceA,aceE,aceF,ackA,acnA,acnB,acpP,acp process b0118,b0156,b0161,b0179,b0180,b0221,b0274,b0313,b0418, S,acs,aec38,aec39,agaS,allA,allB,ansB,arcA2,arnF,ar b0438,b0444,b0460,b0472,b0473,b0480,b0494,b0505,b0511, oF,asd,aspA,astC,atpF,b2726,bcsZ,betI,cadC,caiF,cd b0512,b0526,b0572,b0651,b0659,b0677,b0683,b0714,b0720, d,cfa,chpA,clpB,clpX,coaE,crp,cspA,cspC,cusC,cyd b0721,b0722,b0723,b0724,b0726,b0727,b0728,b0729,b0733, A,cysQ,cysS,dacB,dacC,dadA,dadX,dapA,dapE,dap b0796,b0817,b0839,b0852,b0903,b0924,b0975,b1014,b1062, F,dcyD,deaD,degP,degQ,deoA,deoB,deoC,dgoK,dha b1084,b1089,b1092,b1093,b1094,b1129,b1130,b1131,b1189, K,dkgA,dnaG,eno,epd,erpA,evgS,fabB,fabD,fabG,fa b1190,b1200,b1237,b1262,b1266,b1276,b1279,b1297,b1305, bR,fabZ,fadD,fadE,fadJ,fbaB,fdhE,folA,fruK,fsaB,ft b1306,b1395,b1479,b1530,b1531,b1539,b1611,b1613,b1622, sH,fucI,fucU,fumB,fumC,fur,fusA,gadX,gapA,garD, b1637,b1661,b1680,b1702,b1713,b1717,b1719,b1723,b1724, gcvP,gcvT,glcB,gldA,glgS,glk,glpA,glpB,glpC,glpD, b1743,b1748,b1770,b1778,b1779,b1780,b1805,b1814,b1823, glpK,glpT,glpX,gltA,gntT,gntX,gpmI,groL,groS,grx b1826,b1829,b1842,b1863,b1919,b2097,b2110,b2143,b2159, C,gutM,gutQ,hcaR,hemC,hha,hldE,hns,holE,hscA,ht b2168,b2172,b2218,b2235,b2236,b2240,b2241,b2242,b2243, pG,htpX,hyaD,hybD,hybE,hybF,hypB,hypC,hypD,h b2258,b2277,b2283,b2289,b2296,b2297,b2323,b2324,b2341, ypE,iadA,ilvM,kbl,lgt,lpd,lpxC,lpxD,lrhA,lysA,lysS, b2370,b2388,b2472,b2478,b2498,b2526,b2537,b2563,b2572, maeA,malP,malQ,malY,manA,marA,marR,melA,mg b2581,b2592,b2601,b2608,b2609,b2706,b2707,b2708,b2726, rB,mnmC,mntR,msrB,mtlR,mug,mukB,murG,mutS, b2727,b2728,b2729,b2730,b2733,b2744,b2779,b2782,b2802, nagA,nei,nfo,nrdB,nudH,nuoG,nuoM,ompR,paaH,pc b2804,b2806,b2828,b2830,b2838,b2866,b2867,b2868,b2869, k,pfkB,pflB,pgi,pgpA,pheT,phoP,phoQ,pps,prfB,pri b2870,b2871,b2872,b2878,b2881,b2890,b2891,b2903,b2905, B,pspB,pspC,pta,purA,purB,putA,puuA,pyrC,queC,r b2914,b2927,b2957,b2960,b2976,b2991,b2992,b2993,b3012, bsD,rbsK,rcsC,recR,rfaG,rhaA,rhaB,rhaD,rhaM,rhaR b3049,b3052,b3066,b3068,b3075,b3113,b3114,b3117,b3118, ,ridA,rihA,rimK,rimM,rlmE,rlmM,rne,rpe,rpiA,rplA, b3128,b3136,b3155,b3162,b3178,b3179,b3182,b3186,b3231, rplB,rplC,rplD,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rp b3234,b3296,b3298,b3299,b3309,b3313,b3314,b3315,b3316, lX,rpmF,rpmI,rpmJ,rpoH,rpoZ,rpsC,rpsD,rpsF,rpsG,r b3317,b3318,b3319,b3320,b3321,b3339,b3340,b3341,b3342, psJ,rpsL,rpsM,rpsP,rpsR,rpsS,rraB,rseA,ruvC,sdaA,s b3357,b3386,b3403,b3405,b3413,b3415,b3416,b3417,b3426, dhA,sdhB,sdhC,sdhD,secA,selA,selB,sgaH,soxS,spo b3433,b3461,b3516,b3531,b3556,b3590,b3591,b3601,b3610, T,spy,srlR,sthA,sucA,sucB,sucC,sucD,sufS,surE,tdc b3612,b3617,b3631,b3649,b3650,b3693,b3736,b3748,b3752, A,tdcB,tdcE,tdcF,tdcG,tesA,thrS,tpiA,treC,trmB,trp b3755,b3769,b3805,b3809,b3891,b3901,b3902,b3903,b3904, C,trpH,tufA,tyrS,upp,ushA,xdhA,xdhB,xdhC,xdhD,y b3906,b3919,b3925,b3926,b3945,b3946,b3962,b3963,b3983, bbW,ybeY,ybiH,yciS,ydfG,ydiZ,ydjF,yeaD,yehC,yei GO.0022904 respiratory electron 12 0.00905b3984 b0429,b0430,b0431,b0432,b0733,b0896,b1418,b1590,b1670, b401 b402 b4062 b4069 b4119 b4122 b4133 b4139 QcybB,cydA,cyoA,cyoB,cyoC,cyoD,dmsC,fdoI,nuoG, f fi f hbQ i transport chain b2277,b2283,b3892 nuoM,ydhU,ynfH GO.0051604 protein maturation 12 0.00905 b0156,b0975,b2592,b2726,b2727,b2728,b2729,b2730,b2991, b2726,clpB,erpA,fdhE,hyaD,hybD,hybE,hybF,hypB, b2992,b2993,b3891 hypC,hypD,hypE GO.0006071 glycerol metabolic 9 0.00989 b1200,b2240,b2241,b2242,b2243,b3426,b3925,b3926,b3945 dhaK,gldA,glpA,glpB,glpC,glpD,glpK,glpT,glpX process GO.1902600 hydrogen ion 14 0.0116 b0155,b0429,b0430,b0431,b0432,b0462,b0478,b2277,b2287, acrB,atpF,clcA,cyoA,cyoB,cyoC,cyoD,dctA,dtpB,kef transmembrane b3350,b3496,b3528,b3736,b3962 B,nuoB,nuoM,sthA,ybaL transport GO.0006085 acetyl-CoA biosynthetic 4 0.013 b0115,b2296,b2297,b4069 aceF,ackA,acs,pta process GO.0005975 carbohydrate metabolic 74 0.02 b0090,b0096,b0114,b0115,b0116,b0118,b0179,b0180,b0677, aceA,aceE,aceF,acnA,acnB,acpP,agaS,arnF,bcsZ,deo process b0720,b0726,b0903,b1094,b1200,b1276,b1279,b1479,b1613, C,dgoK,dhaK,dkgA,eno,epd,fabZ,fbaB,fruK,fsaB,fu b1702,b1723,b1779,b1780,b1814,b2097,b2168,b2172,b2240, cI,fucU,gapA,garD,glcB,gldA,glgS,glk,glpA,glpB,gl b2241,b2242,b2243,b2258,b2388,b2708,b2779,b2802,b2804, pC,glpD,glpK,glpT,glpX,gltA,gntT,gpmI,gutQ,hldE,l b2914,b2927,b2976,b3012,b3049,b3052,b3114,b3128,b3136, pd,lpxC,lpxD,maeA,malP,malQ,manA,melA,murG,n b3386,b3403,b3415,b3416,b3417,b3426,b3531,b3612,b3631, agA,pck,pfkB,pflB,pgi,pps,rbsD,rbsK,rfaG,rhaA,rha b3693,b3748,b3752,b3901,b3902,b3903,b3904,b3906,b3919, B,rhaD,rhaM,rhaR,rpe,rpiA,sdaA,sgaH,sucA,tdcE,td b3925,b3926,b3945,b3946,b4015,b4025,b4119,b4196,b4239, cG,tpiA,treC,yciS,yeaD,yeiQ b4381 b4471 GO.0046487 glyoxylate metabolic 7 0.0255 b0118,b0507,b0508,b0509,b1276,b2976,b4015 aceA,acnA,acnB,gcl,gip,glcB,glxR process GO.0009063 cellular amino acid 17 0.0264 b0116,b0727,b1014,b1189,b1748,b1814,b1919,b2297,b2871, astC,dadA,dcyD,gcvP,gcvT,kbl,lpd,pta,putA,sdaA,su catabolic process b2903,b2905,b3113,b3114,b3117,b3118,b3617,b4471 cB,tdcA,tdcB,tdcE,tdcF,tdcG,ygeX GO.0072524 pyridine-containing 17 0.0264 b0114,b0115,b0116,b0726,b1723,b1779,b2097,b2388,b2564, aceE,aceF,eno,epd,fbaB,gapA,glk,gpmI,lpd,pdxJ,pfk compound metabolic b2779,b2914,b2927,b3386,b3612,b3919,b3962,b4025 B,pgi,rpe,rpiA,sthA,sucA,tpiA process GO.0015990 electron transport 5 0.0267 b0429,b0430,b0431,b2277,b2287 cyoB,cyoC,cyoD,nuoB,nuoM coupled proton GO.0072521 purine-containing 28 0.0267 b0103,b0114,b0115,b0116,b0505,b0511,b0512,b0651,b0726, aceE,aceF,allA,allB,atpF,coaE,cydA,eno,fbaB,gapA, compound metabolic b0733,b1131,b1723,b1779,b2097,b2277,b2283,b2388,b2779, glk,gpmI,lpd,nuoG,nuoM,pfkB,pgi,purA,purB,rihA,s process b2866,b2867,b2868,b2881,b3612,b3650,b3736,b3919,b4025, poT,sucA,tpiA,xdhA,xdhB,xdhC,xdhD,ybbW GO.0009071 serine family amino 6 0.028 b0116,b1814,b1919,b2903,b2905,b3117 dcyD,gcvP,gcvT,lpd,sdaA,tdcB acid catabolic process GO.0044267 cellular protein 63 0.0286 b0098,b0161,b0438,b0473,b0526,b0572,b0659,b0729,b0852, acpS,acs,b2726,clpX,cusC,cysS,degP,degQ,evgS,fus metabolic process b1089,b1129,b1637,b1680,b1713,b1717,b1719,b1743,b1778, A,groL,groS,hemC,hscA,htpG,hybF,hypD,hypE,lgt,l b2110,b2218,b2236,b2370,b2526,b2563,b2609,b2726,b2729, ysS,msrB,pheT,phoQ,prfB,rcsC,rimK,rplA,rplB,rplC b2730,b2828,b2890,b2891,b2991,b3186,b3231,b3234,b3296, ,rplD,rplI,rplK,rplM,rplP,rplU,rplV,rplW,rplX,rpmF, b3298,b3299,b3309,b3313,b3314,b3315,b3316,b3317,b3318, rpmI,rpmJ,rpsC,rpsD,rpsF,rpsG,rpsJ,rpsL,rpsM,rpsP, b3319,b3320,b3321,b3339,b3340,b3341,b3342,b3590,b3591, rpsR,rpsS,secA,selA,selB,spy,sucD,sufS,thrS,tufA,ty b3805,b3983,b3984,b4069,b4142,b4143,b4200,b4202,b4203 rS,ybeY,yehC,yfaE GO.0046496 nicotinamide nucleotide 15 0.0344 b0114,b0115,b0116,b0726,b1723,b1779,b2097,b2388,b2779, aceE,aceF,eno,fbaB,gapA,glk,gpmI,lpd,pfkB,pgi,rpe, metabolic process b2914,b3386,b3612,b3919,b3962,b4025 rpiA,sthA,sucA,tpiA GO.0019538 protein metabolic 79 0.0352 b0098,b0156,b0161,b0438,b0473,b0494,b0526,b0572,b0659, acpS,acs,b2726,clpB,clpX,cusC,cysS,dacB,dacC,dap process b0729,b0839,b0852,b0975,b1089,b1129,b1637,b1680,b1713, E,degP,degQ,erpA,evgS,fdhE,ftsH,fusA,groL,groS,h b1717,b1719,b1743,b1778,b1829,b2110,b2218,b2236,b2370, emC,hscA,htpG,htpX,hyaD,hybD,hybE,hybF,hypB,h b2472,b2526,b2563,b2592,b2609,b2726,b2727,b2728,b2729, ypC,hypD,hypE,iadA,lgt,lysS,msrB,pheT,phoQ,prfB b2730,b2828,b2872,b2890,b2891,b2991,b2992,b2993,b3178, ,rcsC,rimK,rplA,rplB,rplC,rplD,rplI,rplK,rplM,rplP,r b3182,b3186,b3231,b3234,b3296,b3298,b3299,b3309,b3313, plU,rplV,rplW,rplX,rpmF,rpmI,rpmJ,rpsC,rpsD,rpsF, b3314,b3315,b3316,b3317,b3318,b3319,b3320,b3321,b3339, rpsG,rpsJ,rpsL,rpsM,rpsP,rpsR,rpsS,secA,selA,selB, b3340,b3341,b3342,b3590,b3591,b3805,b3891,b3983,b3984, spy,sucD,sufS,tesA,thrS,tufA,tyrS,ybeY,yehC,yfaE,y b4069,b4142,b4143,b4200,b4202,b4203,b4328 geY GO.0055086 nucleobase-containing 50 0.0365 b0048,b0090,b0103,b0114,b0115,b0116,b0444,b0480,b0505, aceE,aceF,allA,allB,atpF,cdd,coaE,cydA,deoA,deoB, small molecule b0511,b0512,b0651,b0726,b0733,b1062,b1131,b1539,b1613, deoC,eno,fbaB,folA,gapA,glk,gntX,gpmI,grxC,hldE, metabolic process b1723,b1779,b2097,b2143,b2235,b2277,b2283,b2388,b2498, lpd,manA,murG,nrdB,nuoG,nuoM,pfkB,pgi,purA,pu b2744,b2779,b2866,b2867,b2868,b2870,b2881,b2914,b3052, rB,pyrC,queC,rihA,rpe,rpiA,sgaH,spoT,sthA,sucA,su b3386,b3413,b3610,b3612,b3650,b3736,b3919,b3962,b4025, rE,tpiA,upp,ushA,xdhA,xdhB,xdhC,xdhD,ybbW,ydf b4177,b4196,b4381,b4382,b4383 G,ygeW GO.0006566 threonine metabolic 8 0.0453 b2297,b3113,b3114,b3117,b3118,b3433,b3617,b4471 asd,kbl,pta,tdcA,tdcB,tdcE,tdcF,tdcG process GO.0006733 oxidoreduction 19 0.0453 b0114,b0115,b0116,b0726,b1723,b1779,b2097,b2388,b2779, aceE,aceF,eno,fbaB,gapA,glk,gpmI,lpd,pfkB,pgi,rpe, coenzyme metabolic b2907,b2914,b3386,b3612,b3834,b3919,b3962,b4025,b4039, rpiA,sthA,sucA,tpiA,ubiA,ubiC,ubiH,yigP process b4040 GO.0006072 glycerol-3-phosphate 4 0.0461 b2241,b2242,b3426,b3926 glpA,glpB,glpD,glpK metabolic process Title 3

Table S4. Phenotypic differences of the ancestral and evolved E. coli in PM test. Cell growthb Chemicalsa ΔAUCc Mode of action PM plated Ancestral Evolved 3% Urea - + 2918 Osmolytes PM09.E08 Colistin #2 - + 3618 Colistin PM11.C06 Dichlofluanid #3 - + 3176 Fungicide PM16.C03 Methyltrioctylammonium chloride #3 - + 2683 Membrane, cationic detergent PM19.B03 Oxytetracycline #2 - + 3252 Tetracycline antibiotic PM20.F06 Bromo-succinic acid + - -3562 Carbon sources PM01.F06 D-Glucose-6-phosphate + - -2997 Phosphorus and sulfur sources PM04.C04 Uridine-3'-monophosphate + - -3230 Phosphorus and sulfur sources PM04.D09 O-Phospho-L-tyrosine + - -2062 Phosphorus and sulfur sources PM04.E02 Cefazolin #3 + - -3908 Cephalosporin PM11.E03 Novobiocin #1 + - -3435 DNA topoisomerase PM12.D09 Doxycycline #2 + - -2574 Tetracycline antibiotic PM13.C06 Cefoxitin #3 + - -2081 Cell wall, cephalosporin PM14.E03 Piperacillin #4 + - -2893 Penicillin antibiotic PM14.F08 Domiphen bromide #3 + - -3816 Chemical Sensitivity PM15.D07 Methyl viologen #3 + - -2633 Chemical Sensitivity PM15.E11 Methyl viologen #4 + - -2678 Chemical Sensitivity PM15.E12 Lauryl sulfobetaine #3 + - -2612 Membrane, zwitterionic detergent PM19.G03 Lauryl sulfobetaine #4 + - -3153 Membrane, zwitterionic detergent PM19.G04 Thioridazine #3 + - -3466 Respiration PM20.C03 Oxytetracycline #3 + - 2012 Tetracycline antibiotic PM20.F07 8-Hydroxyquinoline #4 + - -3771 Chelator, lipophilic PM20.G12 Tolylfluanid #4 + - -2778 Chemical Sensitivity PM20.H08 a Chemicals in 96-well PM plates. A # indicates a serially diluted concentration of the chemical (the exact concentration is not provided by Biolog, Co.). b Bacterial cell growth: ‘−’ (no growth), ‘+’ (growth). c Difference in areas under curve (AUC) for the evolved and ancestral cells. A positive value indicates the growth of the evolved cells and no growth of the ancestral cells. d Location of the chemical in the PM plate. See the flagged wells in Fig. S1 for the growth curve.

September 2013 ⎪ Vol. 23⎪ No. 9