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Rabbit Anti-NIPA1/FITC Conjugated antibody

SL19250R-FITC

Product Name: Anti-NIPA1/FITC Chinese Name: FITC标记的NIPA1蛋白抗体 FSP 3; FSP3; Magnesium transporter NIPA1; MGC102724; MGC35570; NIPA 1; NIPA1; NIPA1_HUMAN; Non imprinted in Prader Willi/Angelman syndrome region Alias: protein 1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1; Spastic paraplegia 6 (autosomal dominant); Spastic paraplegia 6 protein; SPG 6; SPG6. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 35kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human NIPA1 Lsotype: IgG Purification: affinitywww.sunlongbiotech.com purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role Product Detail: in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008] Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).

Subcellular Location: Cell membrane. Early endosome. Recruited to the cell membrane in response to low extracellular magnesium.

Tissue Specificity: Widely expressed with highest levels in neuronal tissues.

DISEASE: Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity: Belongs to the NIPA family.

Database links:

Entrez Gene: 123606 Human

Entrez Gene: 233280 Mouse

Entrez Gene: 308668 Rat

Omim: 608145 Human

SwissProt: Q7RTP0 Human SwissProt:www.sunlongbiotech.com Q8BHK1 Mouse Unigene: 511797 Human

Unigene: 389901 Mouse

Unigene: 443911 Mouse

Unigene: 48451 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. www.sunlongbiotech.com