Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Ciraparantag Catalog Number : T10820 CAS Number : 1438492-26-2 Molecular Formula : C22H48N12O2 Molecular Weight : 512.70

Description: Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for , including unfractionated , low-molecular-weight heparin, and certain direct oral anticoagulants.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

H2O 31 mg/mL (60.46 mM) Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) thrombin;factor Xa

In vitro Activity Ciraparantag is a small synthetic and cationic molecule that binds direct Xa inhibitors, direct thrombin inhibitors, and unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge-charge interactions [3].

Reference 1. Das A, et al. Novel for target specific oral anticoagulants. Exp Hematol Oncol. 2015 Sep 15;4:25. 2. Gomez-Outes A, et al. Specific antidotes in development for reversal of novel anticoagulants: a review. Recent Pat Cardiovasc Drug Discov. 2014;9(1):2-10. 3. Hu TY, et al. Reversing effects of novel oral anticoagulants: role of ciraparantag, , and . Vasc Health Risk Manag. 2016 Feb 17;12:35-44. 4. Honickel M, et al. The Reversal of Direct Oral Anticoagulants in Animal Models. Shock. 2017 Aug;48(2):144-158.

FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, please follow the storage recommendations on the product data sheet.

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