Boston CEO Conference-Panel Discussion on Advances in Personalized Medicine

May 29, 2017

Boston CEO

Tue, May 30, 2017 Four Seasons Boston 200 Boylston Street Boston, MA 02116 (617) 338-4400

Cost: $1950 per person Dress Code: Business Attire

Boston CEO is a networking forum for industry CEOs and decision makers in the life sciences. Attendees gain insights from presentations and panels featuring CEOs from several of the world's leading biopharmaceutical companies. Industry leaders in venture capital and private equity also participate.

Speakers and co-hosts include: Paul Biondi, SVP, Head, BD, Bristol-Myers Squibb; Ron Cooper, President & CEO, Albireo Pharma; Robert Coughlin, President & CEO, Mass Bio; Deborah Dunsire, CEO, XTuit Pharmaceuticals; Michael Ehlers, EVP, R&D, Biogen; JC Gutierrez- Ramos, CEO, Synlogic Therapeutics; John Haurum, CEO, F-star Biotechnology; Mary Lynne Hedley, Co-Founder, President & COO, TESARO; William Heiden, CEO, AMAG Pharmaceuticals; Ed Kaye, CEO, Sarepta Therapeutics; Jonathan Lewis, CEO, Samus Therapeutics; Martin Mackay, EVP, Head, R&D, Alexion; John Maraganore, CEO, Alnylam; Geoffrey McDonough, President & CEO, Swedish Orphan Biovitrum; David Meek, CEO, IPSEN; Kia Motesharei, VP, Global Head of BD, Neurology & Immunology, EMD Serono; Francois Nader, Chairman, Acceleron Pharma; Paris Panayiotopoulos, former President & CEO, ARIAD; Adelene Perkins, Chairman & CEO, Infinity Pharmaceuticals; Steven Perrin, CEO & CSO, ALSTDI; Roger Pomerantz, President, CEO & Chairman, Seres Therapeutics; Chandra Ramanathan, VP & Head, East Cost Innovation Center, Bayer; Al Sandrock, CMO & EVP, Neurology Discovery & Development, Biogen; Bob Silverman, Head Externalized Drug Discovery Partnering, Roche; Paula Soteropoulos, CEO, Akcea Therapeutics; Roger Tung, CEO, Concert Pharmaceuticals; Sue Washer, President & CEO, AGTC; Christoph Westphal, Co-Founder & Partner, Longwood Fund

"Boston CEO is the elite meeting for leaders in biotech. This top notch meeting features unrivaled networking and candid discussions on the most pressing topics facing the industry.” - Henri Termeer, former CEO, Genzyme

"The Boston CEO conference is an invaluable opportunity for CEOs to gather in a casual and off-the-record atmosphere and discuss the most pressing issue in the biotech space and beyond. I look forward to these conferences and fully support their mission to continue to grow Boston’s thriving biopharma community.” —John Maraganore, CEO, Alnylam

Please call reservations at the Four Seasons today to book your accommodations. Telephone: (617) 338-4400. Please mention the Boston Biotech Conference rate.

Boston CEO - May 30, 2017 - Four Seasons

Co-hosts: Nessan Bermingham, Paul Biondi, Suzanne Bruhn, Ron Cooper, Robert Coughlin, Deborah Dunsire, Michael Ehlers, Chris Garabedian, JC Gutierrez-Ramos, Mary Lynne Hedley, William Heiden, Ed Kaye, Jay Luly, Martin Mackay, Sandy Macrae, John Maraganore, Geoffrey McDonough, David Meek, Paris Panayiotopoulos, Adelene Perkins, Rob Perez, Roger Pomerantz, Ronald Renaud, Al Sandrock, Paula Soteropoulos, Roger Tung, Sue Washer, Christoph Westphal

Time Agenda

7:30-8:30 amRegistration and Networking Breakfast

Welcoming Remarks -- Remembering a Biotech Legend: Henri Termeer Christoph Westphal, Co-Founder & Partner, Longwood Fund; Rob Perez, Founder & Chairman, Life Science Cares; Deborah 8:30-9:00 am Dunsire, CEO, XTuit Pharmaceuticals; Geoffrey McDonough, President & CEO, Swedish Orphan Biovitrum; Richard Moscicki, Deputy Director, Science Operations, CDER, FDA Moderated Keynote 9:00-9:20 amRichard Moscicki, Deputy Director, Science Operations, CDER, FDA Moderator: Christoph Westphal, Co-Founder & Partner, Longwood Fund

CEO Roundtable Deborah Dunsire, CEO, XTuit Pharmaceuticals; Geoffrey McDonough, President & CEO, Swedish Orphan Biovitrum; Kabir 9:20-9:50 am Nath, President & CEO North America Pharmaceuticals, Otsuka America; Rob Perez, Founder & Chairman, Life Science Cares Moderator: Pierre Jacquet, Managing Director, L.E.K. Consulting

Healthcare Market Outlook -- 2017 and Beyond 9:50-10:20 Robert Guidos, Associate Director, Legislative Affairs, CDER, FDA; Jeff Leerink, Chairman & CEO, Leerink Partners; Jessica am Richman, CEO, uBiome; Thilo Schroeder, Partner, Nextech Invest; Gary Zieziula, President & Managing Director, EMD Serono Moderator: Michael Goettler, Global President, Rare Diseases, Pfizer

10:20-10:50 Networking Break am

Understanding and Managing Growth 10:50-11:20 Mary Lynne Hedley, Co-Founder, President & COO, TESARO; William Heiden, CEO, AMAG Pharmaceuticals; Sanjiv am Patel, CEO, Relay Therapeutics; Shalini Sharp, CFO, Ultragenyx; Timothy Wright, EVP, Strategy, BD, & Innovation, Teva Moderator: Robert Beardsley, COO, Galera Therapeutics

Diversity: Moving from Sound Bite to Implementation 11:20-11:50 Jeff Albers, CEO, Blueprint Medicines; Suzanne Bruhn, President & CEO, Proclara Biosciences; Amri Johnson, Global Head, am Diversity & Inclusion, Novartis Institutes for BioMedical Research; Helen Torley, President & CEO, Halozyme Therapeutics Moderator: Cissy Young, Executive Director, Russell Reynolds

Ensuring Transparency and Drug Value 11:50-12:20 Melissa Bradford-Klug, CBO, Keryx; Thomas Lönngren, former Executive Director, European Medicines Agency; Ed Mascioli, CEO, pm Karos Pharmaceuticals; Gilmore O'Neill, SVP, Late Stage Clinical Development, Biogen Moderator: Ron Cooper, President & CEO, Albireo

12:20-1:20 Networking Lunch pm

Accessing Early-Stage Innovation Ansbert Gadicke, Co-Founder & Managing Director, MPM Capital; Arthur Krieg, CEO & Founder, Checkmate Pharmaceuticals; Brian 1:20-1:50 pmMcVeigh, VP, WWBD Transactions & Investment Management, GlaxoSmithKline; Chandra Ramanathan, Head, East Coast Innovation Center, Bayer; Ken Rhodes, CSO, Yumanity Moderator: Adi Hoess, CEO, Affimed

Therapeutic Market Focus: Microbiome Rodolphe Clerval, CBO, Enterome; Bernat Olle, CEO, Vedanta Biosciences; Jeff Riley, CEO, Synthetic Biologics; Michele 1:50-2:20 pm Trucksis, CMO, Seres Therapeutics Moderator: Todd Krueger, President, AOBiome

Oncology Trends and Predictions Gil Beyen, Chairman & CEO, Erytech; Roman Fleck, CEO, Janpix; Jimmy Lin, CSO, Natera; Oliver Rosen, CMO, Deciphera; Patrick 2:20-2:50 pm Tricoli, CEO, Nanobiotix US Moderator: Jeremy Goldberg, Managing Director, Torreya Partners

2:50-3:20 pmNetworking Break

Building a Biotech: Innovative Business Models JC Gutierrez-Ramos, CEO, Synlogic Therapeutics; Ana Maiques, CEO, Neuroelectrics; Eddie Martucci, Co-Founder & CEO, Akili 3:20-3:50 pm Interactive; Paula Soteropoulos, CEO, Akcea Therapeutics; Gregory Verdine, Founder, CEO, & CSO, FogPharma Moderator: Yuval Cohen, CEO, Corbus Pharmaceuticals

Partner or Go it Alone? Sharon Clarke, CBO, JDP Therapeutics; Kia Motesharei, Global Head, BD, Neurology & Immunology, EMD Serono; Tim 3:50-4:20 pm Noyes, President & CEO, Proteon Therapeutics; Mark Nuttall, Head, MS & Immunology BD&L, Sanofi Genzyme Moderator: Chris Casey, Global Head, Key Accounts & Services, Commercial, inVentiv Health

Next Generation Biotech CEOs and Board Members 4:20-4:50 pmNessan Bermingham, President & CEO, Intellia Therapeutics; Nancy Lurker, President & CEO, pSivida; Francois Nader, Chairman, Acceleron Pharma; Matt Roden, VP, Strategic Corporate Development, Bristol-Myers Squibb; Leslie Williams, Founder, President & CEO, ImmusanT Moderator: Robert Forrester, President & CEO, Verastem

4:50-6:00 pmCocktails and Hors d'oeuvres

May 31, 2017

Time Agenda

7:30-8:30 am Registration and Networking Breakfast

Welcome and Opening Remarks 8:30-8:40 am Roger Tung, CEO, Concert Pharmaceuticals; Sue Washer, President & CEO, AGTC; Steve Cutler, CEO, ICON; Al Sandrock, CMO & EVP, Biogen

Advances in Personalized Medicine Arthur Hiller, CEO, Antyllus; Kenneth Moch, President & CEO, Cognition Therapeutics; Joe Payne, President & 8:40-9:10 am CEO, Arcturus; Steven Perrin, CEO & CSO, ALS Therapy Development Institute; Al Sandrock, CMO & EVP, Biogen Moderator: Robert Silverman, Head, Externalized Drug Discovery Partnering, Roche

Small-Cap and Private Biotech: Leveraging Potential Frederick Beddingfield, President & CEO, Sienna Biopharmaceuticals; Alan Ezekowitz, CEO, Abide Therapeutics; Brian 9:10-9:40 am Leuthner, President & CEO, Edge Therapeutics; Dan Swisher, CEO, Sunesis Pharmaceuticals; Ailis Tweed-Kent, Founder & CEO, Cocoon Biotech Moderator: Gregg Beloff, CFO, Centrexion Therapeutics

Therapeutic Market Focus: Cell & Gene Therapy 9:40-10:10 Al Gianchetti, CEO, XyloCor Therapeutics; Michael Jirousek, COO, Frequency Therapeutics; Jak Knowles, President & CEO, am Exonics Therapeutics; Sam Rasty, COO, Homology Medicines; Amber Salzman, President & CEO, Adverum Biotechnologies Moderator: Pascal Touchon, SVP, Global Head Strategy & BD&L, Novartis

10:10-10:40 Networking Break am

Fireside Chat 10:40-11:00 Michael Ehlers, EVP, R&D, Biogen; David Meek, CEO, IPSEN am Moderator: Christoph Westphal, Co-Founder & Partner, Longwood Fund

Accessing Innovation via M&A and Partnerships Sven Dethlefs, Global Head Respiratory Medicines, Teva; Elcin Ergun Barker, President, New Business, EMD Serono; Jeff 11:00-11:30 Jonker, President, NGM Bio; Cynthia Schwalm, President, North America Commercial Operations, IPSEN; Malcolm am Weir, CEO, Heptares Moderator: Sue Washer, President & CEO, AGTC

Buy or Build? 11:30-12:00 Danguole Altman, President & CEO, Vapogenix; Grace Colon, CEO, InCarda Therapeutics; John Cox, CEO, Bioverativ; Roger pm Tung, CEO, Concert Pharmaceuticals Moderator: Steve Cutler, CEO, ICON

12:00-1:00 Networking Lunch pm

Evolving BioPharma Boards James Geraghty, Chairman, Juniper Pharma; Quang Pham, Founder, Chairman & CEO, Espero Pharmaceuticals; Ronald 1:00-1:30 pm Renaud, CEO, RaNA Therapeutics; David Southwell, President & CEO, Inotek Pharmaceuticals Moderator: Don deBethizy, Chairman, Albumedix A/S Boston-Bound Biotech and Pharma: Impact on Innovation Paul Biondi, SVP, Head, BD, Bristol-Myers Squibb; Paul Bolno, President & CEO, WAVE Life Sciences; Chris Garabedian, Chairman 1:30-2:00 pm & CEO, Xontogeny; Ole Isacson, Founder, NyaCell; Jonathan Lewis, CEO, Samus Therapeutics Moderator: Robert Coughlin, President & CEO, MassBio

Global Markets: Biotechs Across Borders Carolina Alarco, President, Global Marketing & International Markets, Aegerion; Samantha Du, Chairperson & CEO, Zai 2:00-2:30 pm Laboratory; Mark Rothera, CCO, PTC Therapeutics; James Xue, CEO, CANbridge Life Sciences Moderator: Mary Szela, CEO, Novelion Therapeutics

2:30-3:00 pm Networking Break

Fireside Chat 3:00-3:20 pm Robert Coughlin, President & CEO, MassBio; John Maraganore, CEO, Alnylam Moderator: Christoph Westphal, Co-Founder & Partner, Longwood Fund

Achieving Organizational Turnarounds Richard Daly, Chairman & CEO, Neuralstem; Ed Kaye, CEO, Sarepta; Sandy Macrae, CEO, Sangamo Therapeutics; Adelene 3:20-3:50 pm Perkins, Chairman & CEO, Infinity Pharmaceuticals Moderator: Hugh Cole, CBO, ARIAD

M&A Activity Post the IPO-Boom: Impact on Fundraising and Dealmaking Luc Dochez, CEO, Tusk Therapeutics; Luba Greenwood, VP, Global BD & M&A, Roche; John Haurum, CEO, F-star 3:50-4:20 pm Biotechnology; Jim Healy, Managing General Partner, Sofinnova Ventures Moderator: Philippe Lopes-Fernandes, SVP, Global Head, BD & Alliance Management, EMD Serono

Presentation of 2017 Boston CEO Lifetime Achievement Award 4:20-4:30 pm Robert Coughlin, 2016 Honoree; John Maraganore, 2015 Honoree

4:30-5:30 pm Cocktails and Hors d'oeuvres

Hotels

Name Address Phone Four Seasons Boston200 Boylston St, Boston, MA(617) 338-4400