HORSE MAP A FIRST GENERATION RADIATION HYBRID MAP AND A HORSE-HUMAN-MOUSE COMPARATIVE MAP

Synteny FISH RH Human Human Draft Mouse map map map homology sequence & 0 1CA44 location Draft sequence location 20 1CA30 0 VIASH34 LEX030 ASB41 50 LEX039 LEX020 0 1CA22 18 COMT 22 COMT 16.8 16 17.8 17 1CA44 50 COR079 16 1CA30 COR100 ACTA2 89.5 19 33.8 Synteny FISH RH Human Human Draft Mouse Synteny FISH RH Human Human Draft Mouse Synteny FISH RH Human Human Draft Mouse Synteny FISH RH Human Human Draft Mouse CHA1 ACTA2 15 NV031 RBP4 94.2 19 37.7 map map map homology sequence Chromosome & map map map homology sequence Chromosome & map map map homology sequence Chromosome & map map map homology sequence chromosome & CYPIA2 100 DNTT 96.9 19 40.7 location Draft sequence location Draft sequence location Draft sequence location Draft sequence PAX2 0 PHKB FES 14.3 PAX2 101.3 19 44.6 location location location location 14.2 RBP4/ASB41 IGF1R COR059 14.1 DNTT COL17A1 104.6 19 47.5 0 COR065 INSR COL17A1 0 UCD487 CYP17 103.4 19 46.5 COR041 50 10 20 AHT036 OAT 125.0 7 122.5 ASB18 MYH6 13 LEX020? VHL134 PLAU 40 MYH7 PLAU 74.6 14 15.9 HTG19 CYP17 50 2 ACADL 209.3 1 67.4 SLC30A4 UM002 RBBP4 100 NV029 ANXA7 ANXA7 73.9 14 15.5 0 RBBP4 32.9 4 126.7 12.3 COR059 COR037 0 AHT043 0 TKY041 TKY007 12.2 UCD487 COR090 SLC2A1 4 116.9 PTPN12 IL10 0 ASB12 18 ACADL 1 FUCA1 23.7 133.5* COR028 1CA16 TKY003 4 150 PHKB 37.9 12.1 VHL134 TKY015 SLC2A1 50 MATN1 30.9 128.4 8 - SEMA3C 20 TKY013 17 COR078 4 16 AHT036 GOT2 50 50 1CA20 11 OAT RET 42.8 118.9 FUCA1 HDAC1 32.5 127.0 GOT2 49.1 8 95.6 RET TKY024 4 1CA24 11 MATN1 GOT2 COR033 PTPN12 75.7 5 19.4 AHT024 0 SG25 16 HMGCL 23.6 4 133.5 CES2 57.6 8 104.7 AHT084 12 AHT040 TKY003 HDAC1 15 CES2 200 LEX004 1CA25 CNK 100 GPR3 27.8 4 130.7* SG18 SEMA3C 78.9 5 16.0 ASB12 AHT021 COR078 AHT035 CBFB 57.7 8 105.0 100 100 1CA30 13 FGG 15.3 AT3 UM041 TKY024 GPR3 ELA2A 15.1 4 139.5 14 SG18 1CA32 SG02/SG25 50 PACE CBFB 16 KCC1 58.6 8 105.7 AHT048 TCRG TCRG 37.8 13 18.7 HFABP-L AHT035 HMS54 ALPL 21.4 4 135.3 250 16 TKY041 IL10 205.6 1 131.8 14 AHT021/1CA20 FES 15.1 HMGCL 150 KCC1 18 1CA43 ASB17 RHD 25.2 4 132.4 ADD1 AHT022 150 HMS06 LAMC1 MEF2A/FES 0 1CA32 MEF2A 96.8 7 56.6 NPPA GPR3 GLG1 65.4 8 111.0 15 TCRG GCK 43.8 11 71.1 17 LAMC2 150 LAMC2 180.6 1 154.0 ASB08 15 ASB08 D29580 28.7 13 AHT022 PACE FES 87.6 7 69.8* 14 ASB17 UM007 ADH2 GLG1 KARS 66.5 8 111.9 COL1A214 PRG4 AT3 171.4 1 162.1 COR006 AHT040/1CA41 LEX077 ELA2A/ALPL ECE1 21.1 300 GLG1 GCK GCK 16 AHT024 16 PACE 87.6 7 69.8* 200 HMS51 4 135.5* ADH3 KARS CSF2 PTGS2 LAMC1 180.5 1 154.1 1CA41 RHD/NPPA ALPL DPEP1 81.0 8 123.2 13 200 COR046 50 13 HP1-BP74 20.6 4 135.8 12 DPEP1 KARS VHL66 COR046 1CA24 7 D29580 ECE1 ALB MC1R 81.3 8 123.4 PTGS2 PRG4 183.7 1 151.3 COR053 IGF1R 95.8 57.4 12 MC1R EN2 ASB03 17.1 LEX058 COR046 A-14 HP1-BP74 EIF4G3 20.7 4 135.6* 11 UMNe063 AT3 15 PTGS2 184.1 1 150.9 11 PGD CCNI 350 LEX057 12 LAMB3 0 PKLR COR059 TJP1 TJP1 25.4 7 54.7 250 11 LEP GBA LAMB3 208.4 1 194.8 100 1CA20 15 ASB13 11 EIF4G3 NPPA 11.9* 4 143.3* MC1R 11 250 HMS76 GBA COR063 17.2 FGFR3 SG33 1CA43 UCD380 PGD 10.4 4 144.5* 12 MEST ASB03 LAMC1 PKLR 153.1 3 89.9 LEX058 ASB17 12 KARS HMS61 11 HGF 79.8 5 14.9 COR079 UMNe54 14 50 CTSK GBA 153.0 3 90.0 17.3 1CA25 IGF1R COR026 300 400 TCRG HGF 0 NGFB COR100 MC1R 13 12 COR089 COL1A2 92.5 6 4.2 CTSK 148.6 3 95.7 150 13 MTP ADH2 100.4 3 138.9 VDUP1 1CA28 COR035 NPPA AHT090 VCAM1 13 VDUP1 143.9 3 96.8 TKY002 SPARCL1 PDHA2 ADH3 100.5 3 138.7 ASB22 VDUP1 GJA5 1 21.1 TJP1 COR037 13 LAMB1 GJA5 145.4 3 97.3 HMS07 COR051 UCD437 PDHA2 96.9 3 141.7 COR047 LEX033 106.0 S100A6 PK3 50 LAMB1 12 25.3 12 0 CD2 200 TKY002 COR041 4 MTP 100.7 3 138.5 14.1 S100A6 146.47 3 91.4 HTG12 21.2 9 58.2 14.1 0 ADH2/ADH3 HTG07 L16464 NGFB 1CA43 CYP1A2 70.9 0 COR049 LOC51170 88.4 5 101.6* COR089 11 L16464 154.9 LEX20 1CA25 COR043 14.2 14 CD2 COR023 CD2 117.8 3 101.3 21.3 PKM2 PK3 68.2 9 60.2 14.2 A-14(ms) CLU 27.2 57.0 AHT013 11 LEX30 0 TKY106 COR049 8 14 COR005 HNRPDL 83.2 5 97.5 HMS06 100 68.2 9 60.2* LEX050 12 NFIA 50 UCD304 NFIA 61.4 4 95.5 UCD493 PKM2 CLU 14.3 ALB 50 LOC51170 ASB22 LEX58LEX39 COR051 14.3 50 COR028 HMS09 7 HMS05 ATP1A1 117.4 3 101.6 22 UM004 CYP1A2 ANXA2 56.1 9 70.0 4 CCNI 77.8 5 92.8 LEX061 ATP1A1 LEX77 COR078 21.1 13 NGFB ANXA2 50 UM043 MYO5A 48.1 9 75.7 COR033 HNRPDL HMS19 150 116.2 3 102.5 SG25 AHT012 ALB 73.9 5 90.0 COR023 100 MYO5A PK3 COR090 ASB13 PDGFRA VCAM1 SORD 40.6 2 123.2* 21 100 HMS22 HMS19 ASB29 HTG15 VCAM1 101.9 3 116.4 UCD440 23 GRP58 PKM2 21.1 100 LEX07 F11 ? CCNI PDGFRA 54.8 5 74.4 21.2 HMS05 IGL@ GRP58 39.4 2 122.3 COR094 KIT HMB6 14 IGL@ 19.2 16 18.5 UCD487 THBS1 HTG12 A-14 LEX57 HTG07 HTG15 TSHB 24 100 THBS1 35.2 2 119.0 TKY003 KIT 55.3 5 74.8 HTG09 200 VCAM1 UCD493 SORD 2 114.9 21.2 ASB13 22.1 21.3 COL1A2 150 AHT058 ACTC 30.4 FGG 150 4 FGG 156.3 3 83.7 150 HTG09 LEX04 TSHB 115.9 3 102.8 COR006 UCD380 SG18 22.2 CSN1,2 ALB CFTR 115.5 6 18.1 UM002 25 UM004 21.3 SMARCA5 FGG KIT 70.7 5 87.2 0 HMS19 15 NRAS NRAS 115.6 3 103.1 1 FABP3 31.6 0 CSN1,2 LEX33 LEX14 UM004 HMS7 150 ANXA2 UM007 4 127.8 UCD437 22.3 ASB23 22 CFTR SH3GLB1 87.7 3 45.2 FABP3 ASB23 HTG09 LEX34 200 26 UCD440 UCHL1 UCHL1 41.3 5 65.7 LEX50 UOX ASB10 UM043 MYH6 CMA1 22.3 14 47.0 200 HTG02 TGM1 MY05A 22 SMARCA5 145.2 8 80.3* 23 CFTR LEP 126.3 6 29.0 UCD304 16 SH3GLB1 VHL134 27 COR006 MYH6 21.2 14 46.0 4 23 50 48.1 5 71.8 LEX61 AKR1B1 UOX 3 147.1 ACTC 0 UCHL1 TXK LEP MEST 128.6 6 30.7* LEX014 HMS07 14 TGM1 22.0 14 46.7 23 IL2 124.2 3 37.0 24 0 250 VIAS-H34 28 NP IL2 COR094 24 TXK HMS09 LEX034 NP 18.3 12 42.8 24 LEX007 3 CCK 41.5 9 122.9 SG23 AKR1B1 132.4 6 34.4 CMA1 25 CCK 26 DIA1 22 DIA1 39.6 15 83.9 MGAT2 0 UMNe 76 ADD1 2.8 5 33.2 CLCN1 MEST 17 29 MYH6 MGAT2 47.4 12 63.8* 25 26 100 OPN1SW 126.8 6 29.3 50 ADD1 27 OPN1SW COR047 20 COR005 0 300 NP EN2 CLCN1 141.3 6 42.4* LEX014 SMARCA5 AHT097 SG23 HMS62 1CA16 EN2 153.4 5 26.6 1 0 COR053 2 COR035 3 4 CLCN1 5 0 50 20 1CA40 COR026 HTG22 COR063 20 COR043 AHT061 0 AHT042 HTG31 EN2 0 AHT005 0 RYR1 0 COR019 SG23 COR045 FN1 FN1 214.4 1 72.2 COR097 AHT096 6.7 17 56.2 0 15 FN1 MAP2 208.7 1 66.9 C3 50 COR020 50 MAP2 APOA4 C3 19 50 HMS03 CHRNG 16 LDLR 11.3 9 21.8 UBE2L3 INHA INHA 218.4 1 76.3 C3 LDLR 14 PAX3 TKY34 PGR 103.1 9 8.8 2 PGR UBE2L3 18.6 16 16.6 SLC7A10 UCD482 FN1 DRD2 TKY35 50 VHL126 CUL3 PAX3 221.1 1 78.9 15 MMP13 0 DRD2 MMP13 105.0 9 7.2 100 BCR 20.2 10 75.4* RYR1 100 13 100 HBB APOA4 TKY12 AHT025 22 GPI GAPD SCG2 COR010 APOA4 119.0 9 46.4 BCR LIF 27.3 11 4.1 COR008 COR048 SCG2 222.4 1 80.3 PTH TKY034/035 LEX015 17 AHT025 16 TKY023? XRCC1 IFNG NV082 THY1 112.5 LIMK2 28.3 1 3.2 COR013 CUL3 223.3 1 81.1 THY1 TKY012 FDX1 9 52.2 TCF1 100 COR045 12 14.3 APOC3 16 CCND2 150 15 150 SLC7A10 34.3 7 25.6 UGT1A1 150 FDX1 LEX038 DRD2 115.6 9 49.6 LIMK2 HTG08 UCD482 AHT015 MAP2 UGT1A1 232.6 1 88.6 TUB 14.2 LDHA SART3 CCND2 4.1 6 128.0 ARPC3 15 COR048 GPI 35.4 7 24.6 TYR TKY283 LDHA 19.5 7 36.4 15 LIF 14 AMD1 0 ASB06 11 231.4 1 87.6 APOC3 0 11 UMNe70 TCF1 120.2 5 112.9 DNAPK 14 AHT015 RYR1 39.5 7 21.2 PAX3 LEX065 CHRNG 14.1 150 NV018 TKY005 THY1 121.2 9 44.3 NOS1 0 UCD046 ARG1 ASB06 XRCC1 44.6 7 16.7 11 200 APOA1 NOS1 116.6 5 115.8 TG CHRNG HTG33 119.0 9 TCF1 14 SART3 12 LEX070 LHB/CKM CKM 19 PFKM 13 0 APOC3 46.4 UM034 SART3 108.0 5 111.6 13 CRH 66.2 3 19.4* CGA 13 SG30 CKM 46.4 7 14.4 12 TKY272 APOA1 119.0 9 46.4 CRH NKX3A 50 VWF 5.9 6 126.4 TYMS 13 HPD TKY006? 0 COR015 SG30 LHB 50.1 7 34.9 SILV HPD 121.1 5 121.2 PRKDC 47.8 16 15.1* CKM SG20 0 HMS55 12 TKY005 COR004 12 LEX023 50 12 PRKDC SFTPC ERCC2 46.4 7 14.3 TPI1 FLJ11021 121.6 5 121.8* COL10A 12 UM028 COR015 13 VWF 11 50 LEX045 11 FLJ11021 11 SFTPC LPL NKX3A 23.2 14 60.3 COR083 NR1H2 PEX7 100 LEX008 UM015 11 COR095 11 ASB38 10.0 11 0 COR098 11 UCD412 AHT05 VAPA 17 64.6 SFTPC 21.7 14 61.4 LEX062 50 COR004 12 TYR 12 TYMS 100 COR008 12 SG20 19 NR1H2 51.5 7 34.1 LPL 19.6 8 68.2 AHT086 11 LEX066 21.1 100 ASB14 LEX023 13 LPL COR095 TKY282 TYR 91.2 7 77.1 13 NPC1 TYMS 0.9 5 28.5 COR013 12 ERCC2 UM028 COR010 13 50 8 DEFB1 6.7 8 20.5 ASB06 150 COX8 COR003 DEFB1 COR093 ME1 COR083 100 LEX015 COX8 66.1 19 LAMA3 150 LEX029 NPC1 21.0 18 12.2 COR093 14 PLAT 41.4 8 21.4 ASB09 13 21.2 TKY111 99.0 SG28 COR012 PLAT COR019 12 PFKM 48.5 15 WT1 34.0 2 106.0 14 CDH2 COR015 UCD412 150 COR098 UM037 ANK1 41.9 21.7 14 LEX045 14 UMNe74 COR056 DSG2 0 VAPA LAMA3 21.3 18 12.3 8 200 COR070 OPCML 134.4 9 28.5* 100 COR020 21.3 15 HMS03 LEX062/066 150 NV081 HBB HBB 11 5.9 7 93.4 COR097 ASB14 15 ANK1 HSPC038 COR045 15 SG28 15 HBB CDH2 25.4 18 16.6 HSPC038 101.2 15 0 CASP8AP2 CASP8AP2 90.4 4 32.2 HTG31 HBE1 200 16 HTG08 UCD465 TRA1 103.4 10 86.8 TUB HBE1 6.0 7 93.6 LEX23 TYMS DSC2 29.1 18 20.1 OAZIN 102.8 38.6 COR048 16 CGA 87.7 RKJ06 POU2F2 50 15 COL10A1 6 CGA 4 34.5 POU2F2 43.2 7 17.3 LEX19 150 OAZIN COR083 LEX65 22 TRA1 COR070 IFNG 68.0 10 118.5 16 OPCML LYVE-1 19 LEX29 SG32 18 DSG2 29.1 18 20.1 NOV 119.4 15 55.1 17 SG17 ME1 ME1 83.8 9 87.5 200 TUB 8.8 7 98.5 LAMA3 COR085 AMD1 PKFM LYVE-1 21.1 LEX70 MYC 127.7 15 62.4 NV007 AMD1 111.0 10 40.3 UCD465 MAN1 64.9 10 121.2 17 250 PTH 11.5 7 SG32 16 21 ASB09 IFNG INSL3 LYVE-1 100.4 100 COR012 TG 132.6 15 67.1 HMS02 0 COL10A1 WIF1 64.9 10 UCD046 21.2 GALR1 74.5 18 82.9 UM037 MYC 200 UM015 23 SILV RKJ06 121.2 CNTF PTH 14.7 7 102.9 AHT053 LEX08 UM040 COL10A1 116.2 10 34.3 250 18 PAX6 21.3 17 ASB05 SG17 SILV 56.2 10 129.3 19 INSL3 18.4 8 UM033 CDH2 VHL126 LEX09 300 22 HSPC039 44.9 18 77.3* NOV 12 ARPC3 109.8 5 120.4 22 PEX7 24 BDNF CNTF 60.7 19 12.2 UM070 150 18 LEX62 50 AMD1 ARG1 131.5 10 19 AHT019 23 PAI2 DSC2 250 CGA? 24.8 11 PAX6 33.4 2 106.5 NARS 55.6 18 64.8* ASB21 NV067 ASB09 300 IFNG WT1 350 BDNF 29.0 2 110.6 LEX019 SG17 HMS02 PEX7 136.7 10 19.7 200 PAI2 61.3 1 108.1* 100 6 7 PAX6 89300 TG SG30 UM040 SG32 10 350 MAN1 ASB05 UCD412 0 LEX009 WIF1 UCD482 250 COR085 350 UM028 SILV ARPC3 NV067 TKY284 GALR1 50 300 ARG1 0 ARSC1 100 PEX7 350 AHT099 COR003 CLCN4 50 AHT086 HSPC039 UCD428 ANT3 0.9 X 34.2 25 ARSC1 COR074 400 ARSC1 2.6* XY NARS 24 ANT3 NV075 Human chromosome color index CLCN4 9.1 7 4.5 UM033 23 CLCN4 100 UCD502 COR056 COR074 22 LEX026 SG22 ALAS2 TKY039 150 LEX028 0 21 DMD 29.6 X 65.9 P4HB UMNe58 BGN LEX027 P4HB 79.2 121.3 12 3 4 5 6 7 8 910 11121314 15 16171819 20 21 22 X Y 16 DMD OTC 36.3 X 7.3 PDE6G 11 CLCN4 0 OTC Figure 1 The first-generation whole-genome radiation hybrid (RH) map in the horse along with a comparative overview of the map in relation - OTC CRSP2 X 9.8 FASN PDE6G 11 121.3 15 50 CXorf6 CRSP2 to human and mouse gene maps. (Chowdhary et al.) Genome Res. 13 (4). Each diagram of a chromosome shows a G-banded ideogram (ISCNH 1997). FASN 79.4 11 121.6 CRSP2 ALAS2 52.0 X 109.4 ACTG1 ACTG1 F9 14 ALAS2 MAGE-E1 49.1 X 81.8 TK1 75.9 11 118.7 50 AHT079 To the left of the ideogram, all new (red; the present study) and available synteny data are shown. Alphabetically arranged Type I (proximal group) and UCD039 G6PD 0 DDX5 65.8 11 107.5 13 ALDH2ps UCD439 PAK3 LEX010 RBM3 46.8 X 4.3 Type II (distal group) loci are separated by a gap. To the right of the ideogram, all new (red; this study) and available FISH data are shown. For both synteny SG22 MYL4 44.7 11 105.3 12 FASN NV040 100 ARSC1 and FISH data, only those Type II loci are shown that are also present on the RH map. The vertical rounded bars in the RH map represent RH groups UCD039 50 ACE 61.2 11 106.7 11 MG61 47.1 X 4.4 ACE DDX5 LEX068 SCN4A 61.6 11 107.1 XIST 11 MG61 COR091 14 MYL4 GH1 61.6 107.0 (RHMAP 2pt; lod ≥7) are either cytogenetically aligned with anchor markers (shaded) or placed according to available meiotic map results (white). CentiRay ACTG1 UCD439 0 11 12 150 ALAS2 XIST 68.8 X 86.2 ACE ZFX XIST EV12A TK1 MYH2 10.7 11 67.6 13 UM038 MAGE-E1 PGK1 72.9 X 89.0 (cR) distances are shown to the left of the bars, and the deduced order of mapped loci is to the right. Framework markers are depicted in bold italics. LEX068 SCN4A 17 COL1A1 SG31 RBM3 GH 13 47.8 - - 0 COR069 14 ALDH2ps X MNK 72.7 X 88.8 MYL4 50 GH1 TRAP240 59.7 13 99.4 TKY286 MT2A 47.0 8 93.8 PGK1 200 SCN4A ACE 0 TKY031 16 15 AHT028 XIST Following this, regional homology of individual horse (based on mapped Type I loci) with the is shown (colored vertical bars; 12.3 SG24 USP6 54.5 11 85.6* 15 POR 74.1* 5 134.2 UM038 LAMP2 114.3 X 23.9 MYL4 SG24 SG10 EIF3S8 MT2A 16 LAMP2 SG31 12.2 D-8 ZNF207 30.4 11 81.0 15 14 ELN 72.0 5 133.3 AR 62.9 X 80.9 see human chromosome color index). Next to the bars, an ordered assembly of all RH (bold italics) and FISH-mappedType I loci in the horse is shown, NF1 D-8 0 SG13 ADRBK1 50 VHL161 AR PGK1 12.1 GAS 39.4 11 101.1 14 50 RKJ12 ELN POR 7 250 13.9 142.2* MYH2 COL1A1 SG10 13 TKY031 GLRA2 X OMG 11 SG13 ACACA 34.8 11 84.8* CD20 AHT027 ELN GUSB 64.0 5 128.4 17 GLRA2 MNK along with the golden path location of human and mouse orthologs in the respective draft sequences (http://genome.ucsc.edu; version June 2002 in human 0 TRAP240 13 AHT027 GUSB COR074 UMNe60 P4HB 11 EVI2A 29.6 11 80.1 0 UCD497 12 CBLN1 UM030 12 TKY032/033 IGF2 HBA 100 0 TKY039 and February 2002 in mouse). Orthologs showing conserved locus order compared to the derived order of equine are grouped in boxes demons- TKY010 NF1 29.6 11 80.0 ELN CBLN1 39.7 8 87.1 COR091 SUI1 USP6 12 CD20 62.2 19 10.5 11 ASB37 13 ACACA OMG 29.6 11 80.1 11 GUSB LEX03 50 ASB35 11 11 SG03 0 LEX041 21 PLP1 98.3 X 116.0 trating the degree of gene order conservation (conserved linkages) in human and mouse compared to that seen in the horse. Mouse chromosome number GAS 50 PLP1 LEX013 TIM22 0.9 11 77.0 COR009 11 12 19 VHL047 LEX10 50 D-8 NF1 TKY033/32 CD20 EIF3S8 27.8 7 116.4* LEX024 SKIP 1.5 11 76.2* 12 ROM1 64.8 19 8.2 ASB37 is shown in bold before the sequence location of each locus. Yellow-shaded horizontal regions represent loci that have preserved gene order (or are HLM2 14.1 OMG NV090 COR030 SG08 ASB01 LEX22 UM001 100 RCV1 10.1 11 68.2 13 EIF3S8 PRM1 16 TKY038 14.2 TKY010 13 AHT045 ROM1 ASB37 0 LEX24 22 clustered together) in horse, human, and mouse. These clusters signify core ancestral segments. A ? denotes loci with controversial cytogenetic location; LEX68 COR058 100 CHRM1 65.1 19 8.0 ASB01 100 COL4A5 103.0 X 120.7 PNMT PNMT 37.3 11 99.1 20 PRM1 11.1 16 10.2 COL4A5 SG13 14.3 EVI2A SG10 COOR009 COR069 LEX26 23 TKY038 FACL4 104.1 X 121.5 SSTR2 MAPT 43.5 11 105.0 ADRBK1 69.5 19 6.5 NV098 FACL4 * denotes position of mouse loci deducted fromtightly linked markers. SG22 150 ZNF207 AHT027? COR030 LEX41 14 LEX27 PAK3 105.6 X 122.9 RCV1 SSTR2 71.0 11 114.5 UCD411 PRM1 0 HBA1 24 PAK3 14 CHRM1 150 UCD411 HBA1 0.2 11 32.2 150 UCD439 15 MAPT OMG VHL161 LEX28 UCD497 IGF2 0.5 7 133.0 15 25 VHL081 VHL081 UCD457 16 HLM2 NF1 GUCY2D 8.3 11 69.8 IGF2 ADRBK1 16 HBA1 200 TP53 8.0 11 70.1 SG31 26 AHT087 GUCY2D COR058 0 LEX022 200 UCD428 IGF2 IGSF1 IGSF1 IGSF1 125.0 X 35.4* Acknowledgements: This project was funded by grants from the Texas Higher Education Board (ARP 010366-0162-2001), NRICGP/USDA Grant 11 TIM22 12 13 UCD502 27 GPC3 250 50 GPC3 GPC3 127.3 X 37.8 SKIP UM038 F9 2000-03510 (LCS), Texas Equine Research Foundation (BPC, LCS), Link Endowment (BPC, LCS), The Morris Animal Foundation and the Dorothy HPRT1 HPRT1 128.2 X 38.6 28 Russell Havemeyer Foundation (main sponsor of the poster). Additional support was available from the NRSP-8 Coordinators Fund. We are LEX003 F9 133.1 X 43.0 300 TKY020 100 TKY020 29 extremely thankful to Drs. Richard Brandon, Gabriella Lindgren and Imke Tammen for providing equine primer pairs for various markers (see CXorf6 CXorf6 CXorf6 143.9 X 54.3* RCV1 Table 1). Dee Honeycutt is gratefully 350 BGN BGN 146.8 X 56.7 HLM2 G6PD G6PD 147.8 X 57.6 acknowledged for her excellent management of the horse RH panel. 0 AHT063 X GUCY2D AHT081 400 TP53 HTG03 50 UMPS 121.1 16 33.7 11 SLC6A3 TKY279 0 AHT029 SLC6A3 1.4 13 70.6 11 RHO RHO 126.0 6 116.7 RASA1 EN1 116.8 1 121.3 12 AHT029 RASA1 85.4 13 82.3 0 LEX046 AHT037 TFDP2 138.6 9 96.7* 0 UCD136 CANX 11 100 11 11 PROC 125.4 18 32.2 MGAT1 IL1B 12 COR007 UMNe52 PROC 13 50 MGAT1 180.3 11 49.6 IL1RN 111.0 2 24.6 COR039 COR103/104 PAX8 IL1RN CP 12 UMPS 25.1 11.9 CHRNA CANX 179.2 11 50.7 EN1 IL1B 110.7 2 130.3 RARB RARB 14 12 MTMR6 COR007 12 0 MCM6 MCM6 134.2 1 129.1 11 COR103/104 0 0 COR062 14 151.1 SPTBN1 13 IL1RN 50 IL1B GLB1 COR105 0 UM010 UM010 SPARC 11 55.8 13 HTG03 AHT014 TGFBR2 30.2 9 117.3 MTMR6 23.8 14 51.3* CXCR4 PROC CXCR4 LCT 134.2 EDNRB 13 TKY287 12 SDNSF IL1B COR076 1 129.0* 13 CXCR4 134.5 1 129.3 I-12 ADRB2 SPARC 0 SPARC PDE6A 149.3 18 61.5 RARB AHT037 COR052 GLB1 32.3 9 115.5 RNF6 MTMR6 TKY019 SST I-12 15 14 SFTPB SFTPB 85.7 6 73.1* 14 LEX048 MTMR6 RNF6 24.8 HDAC1? 50 LEX054 9 RPS6 19.7 4 84.1 ADRB2 ADRB2 148.2 18 62.4* B-8 RHO 50 14 ALOX5AP 50 COR072 5 145.1* CAMK4 PDE6A 100 CRTAP 32.4 9 115.5 13 AHT041 50 AHT041 DPYSL3 B-8 15 TGFBR2 RB1 RNF6 HOXD 14 NV077 16 ADRB2 LCT SLC21A2 TFDP2 15 AHT094 TLOC1 166.9 3 30.6* CSF1R UM032 50 DPYSL3 146.7 18 43.4 21.1 LEX051 GLB1 PDCD6IP 33.1 9 114.7 MSTN GLI2 118.7 1 119.4 AHT02 ASB15 LEX076 ALOX5AP 29.8 5 148.2* 100 UMNe50 14 DPYSL3 TF 16 RARB 100 RPS6 HEXB 21.2 NV083 MDH1 63.9 11 21.5 100 CRTAP HRH1 11.2 6 115.3 NV024 NEB GLI2 AHT080 ASB07 MITF 68.5 6 98.8 UM032 ASB02 150 2 15 100 AHT052 SPARC FGF1 FGF1 141.8 18 39.0 TGFBR2 TGFBR2 PDCD6IP BRCA2 31.4 5 149.7 TKY011 SPTBN1 54.7 11 30.0* PB1 51.7 14 26.2* 21.1 BRCA2 TTN CXCR4 HMS46 ASB11 15 MITF HTG23 IL3 100 VHL209 ASB15 21.3 MDH1 GLB1 0 AHT038 21 5 IL3 130.9 11 54.7 21.1 CRTAP GPX1 48.7 9 109.2 TKY102 150 LEX047 B-8 3 COR007 SG07 2 COR044 ASB07 MPZ03 AHT038 SG07 150 SPTBN1 ASB15 SDNSF 47.1 COR039 LEX059 LTF 45.7 9 112.1 21.2 0 HMS41 21 NEB 150.0 2 52.8 16 3 COR014 22 17 86.5* HRH1 COR032 RB1 COR062 TLOC1 HTG29 SDNSF 0 21.2 NEB NEB LOX 121.1 18 52.7 COR052 GPX1 50 PB1 ACAA1 38.0 9 120.5 COR067 COR067 13 SGCG 21.7 200 ASB07 SOX2 178.1* 3 34.5 22.1 COR042 ASB02 SDNSF FSHR 49.2 17 88.3 21.3 14 52.3 POH1 COR092 COR002 0 SOD2ps SG21 COR096 POH1 160.2 2 62.4 HTG24 COR075 SG21 COR064 LTF COR072 CA014 HMS08 17 SOX2 22.2 LOX 50 GCG 0 LEX43 CAMK4 23 FSHR ASB02 21.3 ACAA1 HTG13 HLM3 22 LEX040 COR014 50 HMS25 I-12 AHT083 HTG03 ACPP 100 BRCA2 250 HTG28 GCG 161.0 2 63.1 LEX47 22.3 SG06 SG06 ACPP 128.9 9 105.0 RB1 46.8 14 64.1 CHRNA 18 LEX036 0 COR042 ZNF148 GPX1 HMS41 HMS41 HMS46 COR096 LEX35 AHT088 ASB19 ASB19 HTG13 ASB42 ZNF148 121.7 16 33.1 100 LEX055 23 LEX073 LEX78 SOD2ps COR075 22.1 22 SGCG 0 CHRNA 50 CSPG2 CAMK4 110.1 18 33.1 24 COR077 RBP1 LEX55 LEX36 23 CAD 27.3 5 29.7* I-18 LTF HTG17 TKY004 SST UM010 LEX078 COR076 TKY104 22.2 CPA3 CPA3 145.5 3 19.9 LEX76 CHRNA 173.6 2 74.4 21 SST 184.2 16 23.6 50 0 ASB42 TTN LEX40 NDUFS8 ? CAMK4 COR002 CAD POMC 25.3 12 3.8 LEX48 NCK1 COR032 HTG28 24 LEX035 VHL209 COR077 COR075 22.3 RBP1 136.1 9 98.9 NV24 23 150 TTN LEX73 100 HEXB 25 UCD505 COR032 50 ASB25 KNG 183.2 16 22.8 24 HMS01 POMC 0 LEX56 LEX54 TTN 177.4 2 KNG HMS01 A APOB 21.1 12 7.8 UCD014 EDNRB HMS25 EDNRB 76.4 14 95.0 HTG17 MPZ003 HMGCR 23.1 SLC21A2 NCK1 133.5 9 101.0 24 0 22 TKY004 LEX46 COR014 LEX59 50 COL3A1 187.9 1 45.9* COR044 25 CSPG2 81.5 13 86.7 TF DCT SG07 25 COR101 0 0 AHT02 23.2 LEX056 130.6 HMS08 LEX51 26 APOB MPZ002 SLC21A2 9 103.7 25 DZIP1 DCT 93.4 14 109.2 TKY017 100 MSTN 189.1 1 53.6 23 TKY009 81.7 HMS25 COL3A1 ASB25 26 CRTL1 13 86.6 COR042 ODC1 10.3 12 17.6 23.3 KNG ? UCD136 CSPG2 SG06 HTG06 UCD505 MPZ002 TF 130.4 9 103.9 26 AOX1 AOX1 199.6 1 58.5 24 ZNF-U69274 98.0 HEXB 72.7 13 94.5 24 I-18 100 26 TKY017 NV011 CRTL1 SG21 27 DZIP1 94.5 14 110.1* UCD387 50 27 HMGCR 73.4 13 93.9 ODC1 AGTR1 I-18 27 CD28 150 MSTN CD28 202.7 1 61.3 COR092 PROS1 90.3 16 63.1* LEX078 25 CP MSTN 25 PROS1 UCD387 ASB11 HEXB GYG COR064 HMGCR 150 HLM3 AGTR1 145.3 3 20.0* 100 TKY009 14 15 16 17 18 19 ZNF-U69274 AHT060 200 AHT055 CP CP 145.8 3 19.6 GYG 145.6 3 19.8 MBNL 250 MBNL 148.9 3 61.1 AHT091 EDN1 12.3 13 41.8 0 COR087 0 AHT100 F13A1 6.1 UM012 COR029 LEX042 CD164 109.5 10 41.5 50 HTG05 0 AHT030 50 NV005 NUMB 11 AHT018 HSPA1A 31.8 17 34.0 COR060 EDN1 HLA-DRA 32.4 17 33.4 AHT095 HIF1A 12 UMNe64 0 COR055 EDN1 100 UMNe67 0 COR001 TNFA 31.6 17 34.3 UM019 13 F13A1 LEX052 0 AHT004 CLPS AHT039 LEX064 CYP21A2 32.0 17 33.9 0 TKY021 TKY285 COL9A1 14 0 DQA 50 CD164 50 PDYN 1.9 2 130.6 C4 33.7 17 33.8 11 SG14 KIAA0073 65.0 ADA 11 FBP1 88.1 13 61.6 TKY036 ELA-DRA 15 DOB 11 TLE4 11 50 TKY021 SG16 ASIP PRNP 4.6 2 132.9 TKY037 DMA GSTA1 52.6 12 AHT039 11 ITPR3 50 C9 12 SG14 HTG10 12 HTG14 CNFTR TLE4 73.3 19 14.0* COX4P1 COX4P1 - XPA 91.2 4 45.0 HSPA1A 0 EDN3 100 12 AHT032 SG16 CTLA3 CTLA3 54.5 13 110.6 100 66.5 0 ABL1 16 ITPR3 HLA-DQA 32.7 17 33.3* CTLA3 FBP1 ALDH1A1 ALDH1A1 19 20.2 100 12 ELA-DRA 13 COR073 GHRH 13 IFNA1 13 UMNe65 HLA-DOB 32.7 17 33.4 GHR HMGCS1 43.5 13 AHT030 BMP2 BMP2 6.7 2 134.5 UMNe51 AHT004 NUMB 71.2 12 78.4 XPA TNFA 6 GNAS1 IFNB1 13 EA2C4 HSPA5 AHT051 ABL1 124.6 2 32.1* 100 HLA-DMA 32.9 17 33.2 KIAA0073 50 LEX060 150 CDKN2A 22.2 4 86.7 13 UM011 IL7R 14 150 TGFB3 HIF1A 59.4 12 68.5 50 ITPR3 33.5 17 26.3 COR068 PRNP 14 TYRP1 CDKN2A ASB39 AHT04 SPTB 14 TXN NV043 COR050 UMNe56 HMGCS1 TYRP1 12.8 4 78.1 150 21.1 AHT020 PDYN 14 TKY036 FLRT2 MUT 15 GHR 42.8 15 3.1 AHCY TYPR1 LEX063 COR024 HSPA5 119.1 2 35.1 HMS42 CYP21A2 0 AHCY 32.6 2 155.8 200 9 SPTB 62.5 12 71.2 14 HSPA5 CTLA3 100 GHR 5 TKY040?? UM027 TKY037 C4 SGP28 C9 39.4 15 6.2 COR055 COR025 100 9 HTG05 MUT 49.4 17 39.9 15 STS-D29077 ? 0 COR022 14 COR061 21.2 GSTA1 COR068 16 GHR C9 ASB39 UMNe69 200 TGFB3 73.9 12 80.7 COR018 15 COR001 PRNP 20 COR084 15 COR061 AHT032 LEX074 AHT007 LEX52 COR080 GGTA1 GGTA1 2 35.8 ITPR3 50 SGP28 49.6 17 39.7 COR073 C9 TKY280 16 UMNe77 ASIP 32.6 2 155.8 VLDLR UM022 UCD405 HMS04 150 FLJ14054 32.5 15 11.8* COR016 ASIP LEX53 VLDLR 2.7 19 26.9 COR087 CALM1 FLRT2 83.5 12 89.9* 16 0 LEX71 CSNK2B CSNK2B 31.6 17 34.2 HTG10 17 NPR3 50 UCD405 COR018 EPB72 115.2 2 35.7 FLJ14054 COR022 0 LEX053 250 MUT COR050 IL7R HTG32 NPR3 32.4 15 11.8 LEX63 LEX32 15 FLRT2 UCD464 UM011 21.3 BF 31.9 17 33.9* LEX37 RPN2 LEX002 RPN2 35.5 2 158.1 16 IFNB1 21.4 4 85.9 CALM1 88.3 12 94.3 17 EPB72 TXN 100 IL7R HMS47 17 IFNB1 TXN 103.8 4 56.8 BF LEX071 18 BASP1 IL7R 36.0 9.5 ASIP SG04 IFNB1 LEX42 50 LEX60 15 IFNA1 SERPINA1 14 COR080 0 BASP1 HTG14 100 HTG21 UM019 17 MTAP IFNA1 21.7 4 86.2 16.1 300 SGP28 COL9A1 SG14 RPN2 MTAP IFNA1 LEX74 18 22 BASP1 17.2 15 25.4* LEX002 18 HMS47 18 PI/AAT7 SERPINA1 92.3 12 - DBH UCD464 DBH 127.5 2 27.3 NV021 PIM1 37.1 17 28.7 SG01 UM022 COR084 16.2 150 SG16 19.2 LEX037 SPIN MTAP 22.1 4 86.5 UM012 (SERPINA1) LEX032 UCD464 SG01 19 SG19 ADA 42.9 2 164.6 19 19 24 PIM1 HMS42 COL9A1 70.8 1 24.5 150 COR016 UM027 SIGMAR1 SPIN 16.3 50 SPIN 82.0 13 50.4 350 COL9A1 AHT031 SG04 0 SIGMAR1 AHT078 HMS42 ADA SG04 SIGMAR1 34.9 4 41.5 COR024 20 21 22 200 23 24 25 400 HMS47 GNAS1 57.1 2 175.5 UCD467 250 GNAS1 450 COR025 EDN3 57.6 2 176.0 SG19 300 AHT031 EDN3

LEX018 11 0 HNRPU

11 11 COR021 12 11 500 LEX025 A-17 12 12 HTG30 COR082 50 0 11 AHT062 11 0 COR071 0 ASB38 KITLG 12 PLG 0 PLG PLG 160.4 17 11.7 13 UM003 KITLG 88.1 10 100.2 AKR1C3 DCSR1 13 CA005 13 HTG27 12 A-17 LEX044 13 100 12 HNRPU 242.9 1 179.6 KRTAP8 16 89.5 VIM VIASH39 IGF2R IGF2R 159.8 17 11.9 ETS2 TKY275 ARSA TKY018 TMPO 98.3 10 91.3 100 13 14 LEX044 50 COR040 14 50 ESR1 AHT033 14 50 TMPO TKY112 HMS18 50 KRTAP8 COR099 ASB38 HMS45 CYP2D 12 1 PLG TKY274 15 14 150 COR027 CTSLL 46.5 13 EB2E8 IGF1 IGF1 LEX25 UMNe78 14 COR038 COR017 15 F11 IGF1 IGF1 101.8 10 88.0 CTSLL DSCR1 21 SOD1 29.6 16 90.8 100 VIM HMS18 TGFB2 217.1 1 187.7 VIP 152.6 A-17 EB2E8 100 100 LEX005 4 F11 188.2 8 44.4 VIM 17.2 2 13.6 LEX75 0 VIAS-H21 6 VIP 10 5.4 MGF1 COR021 TXNL2 AHT033 15 NV070 COR040 TGFB2 COR038 15 100 EB2E8 DSCR1 32.4 16 93.0 AHT082 16 CYP2D@ 15 200 10 TXNL2 130.7 7 127.5 UCD455 14 PCMT1 DSCR1 HMS45 TIMP3 COR027 LOC91452 VIAS-H21 VIAS-H21 PCMT1 149.6 10 7.4 COR071 HMS45 16 TIMP3 29.8 10 86.4 VHL020 AHT034 LEX005 150 ARSA LOC91452 27.2 23.3* 50 ETS2 36.7 16 96.6 150 UCD425 COR082 2 TKY278 LEX44 SOD1 LEX05 CYP2D@ 39.0 15 83.1 AHT034 150 MX1 39.3 16 98.6 COR017 17 UCD425 22 250 VHL20 16 ESR1 151.6 10 4.5 16 UM003 VIAS-H39 AHT023 ESR1 TKY105 CRYAA 41.1 17 30.8 17 CYP2D@ ARSA 47.5 15 83.2 AKR1C3 AKR1C3 15 ETS2 UCD005 BLG1/2 16 AHT023 MX1 18 ASB43 AKR1C3 5.1 13 3.8* 100 17 18 UCD425 BLG1/2 ASB43 17 CRYAA LEX075 26 27 28 29 30 UCD455 31 (POSTER SUPPORTED BY FUNDING FROM THE DOROTHY RUSSELL HAVEMEYER FOUNDATION)