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E N O A E S S S L T A E A C R C I N S M S E E H C C TI N O CA March 2017 Vol. XCV, No.7 N • AMERI

Monthly Meeting 2016 Process Chemistry

Richards Medal Award Meeting at Harvard Symposium

A report by Luigi Anzalone, Steve Canham, Katherine Lee, Richards Medal Steve Mennen and Xianglin Shi Address January Monthly Meeting

By Gabor A. Somorjai A report by Carol Mulrooney and Catherine Rawlins Hot Science at the 2016 NESACS Process Chemistry Symposium By Luigi Anzalone, Steve Canham, Katherine Lee, Steve Mennen and Xianglin Shi Over 180 people convened for a diverse tential clients over breakfast, lunch and scientific program focused on process coffee breaks, as well as at a lively net- chemistry at the annual NESACS working reception at the close of the day. Process Chemistry Symposium, held at The 2016 NESACS Process Chem- the Novartis Institutes for BioMedical istry Symposium was made possible Research in Cambridge, MA on October thanks to gracious financial support from 20, 2016. Novartis, Amgen Inc., Biogen, Vertex The symposium showcased eight Pharmaceuticals, Johnson Matthey, SK speakers, who represented academic in- Life Science, DavosPharma, Millipore stitutions from across the United States, Sigma, Mettler Toledo, Navin Fluorine, and biotech and pharmaceutical compa- PCI Synthesis, Strem Chemicals, Inc., nies from the local scientific community: and Pharmacore. L-R: Dominique Hebraults, Richard Braatz and Matthew Beaver, Amgen, Inc.; Richard The symposium committee would Steve Mennen Braatz, MIT; Abigail Doyle, Princeton like to thank Novartis for hosting the University; , Harvard Uni- symposium, and dedicated individuals versity; Albert Kwok, Biogen; Kian Tan, including Anna Singer, Jim Piper, Ken Novartis Institutes for BioMedical Re- Drew, Rebecca Johnson, Allie Roper, search; Pete Ruggiero, Vertex Pharma- Karen Briner, Scott Plummer, Pete Del- ceuticals Incorporated; and Jin-Quan gado, Angie Angeles, Michael Humora, Yu, The Scripps Research Institute. Adam Looker, Don Walker, and Elaine Lee for helping to make the symposium a success. We are pleased to note that the 2015 NESACS Process Symposium garnered a 2016 ACS ChemLuminary Award for Best Industry Event. Mark your calendars – October 12, L-R: Olga Gocharova and Luigi Anzalone 2017 – for the 2017 NESACS Process Chemistry Symposium, to be held at Amgen, Inc., Cambridge, MA. Con- Above, from left to right: Kian Tan, Kathy Lee, firmed speakers include Stephen Buch- Jin-Quan Yu, Eric Jacobsen, Abigail Doyle, Steve wald, MIT; Sarah Reisman, California Canham, Steve Mennen and Angie Angeles Institute of Technology; Richmond Sar- The program included lectures by pong, University of California at Berke- ley; and Corinna Schindler, University academic speakers on cutting-edge or- u ganic synthesis methodology, , of Michigan. and slug-flow crystallization; and fea- tured real-life examples from captivat- ing speakers from industry on topics L-R: Suzie Opalka, Erwin Irdam and Bin Ma including process development, flow technology, crystallization-induced dy- namic resolution, and C-H activation. The event drew attendees from over 40 What’s Yours? companies and academic institutions. Many local employers post positions In addition to delivering a powerful on the NESACS job board. scientific program, the day-long sympo- L-R: Diane Grob Schmidt, Steve Mennen, Jen- sium fostered many opportunities for at- nifer Maclachlan and Jack Driscoll at the 18th Find yours at tendees to interact with each other and Annual ChemLuminary Awards Celebration at www.nesacs.org/jobs for the representatives from symposium the ACS National Meeting in Philadelphia, PA, sponsor companies to connect with po- August 23, 2016.

2 The Nucleus March 2017 The Northeastern Section of the American- Chemical Society, Inc. Contents Office: Anna Singer, 12 Corcoran Road, Burlington, MA 01803 (Voice or FAX) 781-272-1966. 2016 Process Chemistry Symposium Report 2 e-mail: [email protected] ______NESACS Homepage: By Luigi Anzalone, Steve Canham, Katherine Lee, Steve Mennen and Xianglin Shi http://www.NESACS.org Officers 2017 January Monthly Meeting 4 Chair ______Leland L. Johnson, Jr. Conditas Biotechnology Group A report by Carol Mulrooney and Catherine Rawlins P.O.Box 540 Brookline, MA 02446 Monthly Meeting 5 617-304-6474 [email protected] Richards Medal Award Meeting at Harvard University. Gabor A. Somorjai to Chair-Elect receive 2016 Richards Medal. Mindy Levine 35 Cottage St Richards Award Address 6 Sharon, MA 02067-2130 ______(516)697-9688 [email protected] By Gabor A. Somorjai Immediate Past Chair Jerry P. Jasinski Announcements 8,9 Keene State College ______Keene, NH 03435-2001 The Norris-Richards Undergraduate Summer Research Scholarships, Philip [email protected] Levine Memorial Prize, ACS Awards to Cynthia Friend and David R. Walt, 2017 Secretary Michael Singer Esselen Award to Neil M. Donahue MilliporeSigma 3 Strathmore Rd, Natick, MA 01760 STEM Journey IV: NASA’s Mission to Mars 10 774-290-1391, [email protected] ______Treasurer Ashis Saha STEM Journey III 11 67 Bow St ______Arlington, MA 02474-2744 A report by Jack Driscoll and Jennifer Maclachlan (978)212-5462 [email protected] Adventures in Proofreading 13 Auditor ______Patrick Gordon By Donald O. Rickter Archivist Ken Mattes Cover: Trustees Professor Gabor A. Somorjai, 2016 Richards Medal Recipient (Photo Ruth Tanner, Peter C. Meltzer, Dorothy Phillips courtesy of Professor Somorjai). Directors-at-Large Ralph Scannell, John Burke, David Harris, Editorial Deadlines: Ioannis Papayannopoulos, Michael P. Filosa, May 2017 Issue: March 15, 2017 John Neumeyer Councilors/Alternate Councilors Summer-September 2017 Issue: July 15, 2017 Term Ends 12/31/2017 Michael P. Filosa John Podobinski Doris I. Lewis Sonja Strah-Pleynet Patricia A. Mabrouk Anna Waclawa Sromek Mark Tebbe Mary Burgess Morton Z. Hoffman Ralph Scannell Term Ends 12/31/2018 Katherine Lee Mukund S. Chorghade Catherine E. Costello Andrew Scholte Ruth Tanner R. Christian Moreton The Nucleus is published monthly, except June and August, by the Northeastern Section of the American Jackie O’Neil Ajay Purohit Chemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Text Kenneth Mattes Robert Lichter must be received by the editor six weeks before the date of issue. Term Ends 12/31/2019 Thomas R. Gilbert Leland L. Johnson, Jr. Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email: Mary Jane Shultz Mary A. Mahaney [email protected]; Tel: 508-843-9070 Michael Singer Jerry P. Jasinski Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466 Lisa Marcaurelle Sofia Santos Morton Hoffman Marietta Schwartz Patrick M. Gordon Board of Publications: James Phillips (Chair), Mary Mahaney, Ajay Purohit, Ken Drew All Chairs of standing Business Manager: Joshua Fine, Email: [email protected] Committees, the editor of THE NUCLEUS, and Advertising Manager: Vacant: contact Michael Filosa at [email protected] the Trustees of Section Calendar Coordinator: Xavier Herault, Email: [email protected] Funds are members of the Photographers: Morton Hoffman and James Phillips Board of Directors. Any Proofreaders: Donald O. Rickter, Morton Z. Hoffman, Carol Mulrooney Coun cilor of the American Chemical Society residing within the section area is an ex officio Webmaster: Roy Hagen, Email: [email protected] member of the Board of Directors. Copyright 2017, Northeastern Section of the American Chemical Society, Inc.

The Nucleus March 2017 3 January Monthly Meeting NESACS Sponsors 2016 Platinum $5000+ By Carol Mulrooney and Catherine Rawlins Amgen The first NESACS meeting of 2017 Biogen with ACS President Allison Campbell Johnson Matthey had several notable events. PCI Synthesis The day started at noon with a Sigma-Aldrich lunch at Catalyst restaurant in Cam- SK Life Science bridge, sponsored by the WCC. Here a Gold $3500 up to $5000 diverse group of women chemists at varying stages of their careers met with Navin Fluorine Allison, shared their backgrounds, and Silver $2000 up to $3500 connected in a small, informal setting Abbvie with many vibrant discussions. American Chemical Society IAC Grant Chemists shared their experiences Boston Foundation Esselen addressing issues such as work-life bal- Bristol-Myers Squibb ance and finding new career opportuni- Mettler Toledo ties. One important lesson the attendees After this meeting, Allison was Novartis learned from Allison is if you have a pet given a tour of the automation and snake, don’t mention it to her! (She does chemistry labs of the Broad Institute. Strem Chemicals not like snakes at all, not a surprise for The day was completed by a reception, Vertex Pharmaceuticals someone who lives in rattlesnake coun- dinner, and then Allison’s presentation Bronze $500 up to $2000 try.) titled “ACS Presidential Focus: Initia- Alexion The WCC is looking forward to tives and Symposia for 2017”. AstraZeneca hosting more of these lunches at future Highlights of the talk included pre- Chemical Computing Group NESACS monthly meetings and en- views of the Presidential Symposia, Cydan Development abling more women chemists to interact some to be held at the April 2017 Na- DeuteRx LLC with NESACS guest speakers. tional Meeting and some in Washington Following lunch, lead members of DC. There will be new workshops devel- GL Chemtech International Limited the Younger Chemists Committee and oped to promote outreach, helping ACS JEOL USA Inc the Government Affairs Committee re- leaders speak effectively to Congress Pharmacore convened at the Broad Institute for a and the public. A safety summit will Relay Therapeutics joint meeting with Allison. There, Alli- bring together Presidents and Directors Selvita, Inc. son was able to touch on her three main of international chemical societies Toxicon foci for her term as President with one building common principles and prac- being an emphasis on scientists interact- tices. ing with Congress. Allison also shared her career path Since the goals and members of and insights into helping young chemists ple helping find someone who would be these committees were in line with each achieve their goals. One of the major able to do the work and offering help in other, much was discussed on how to at- challenges scientists face as they ad- the future), asking for help when needed, tract more young chemists to focus on vance in their careers is work-life bal- communicating expectations (especially science policy. ance. With this challenge, there were five with family when planning a busy work The Younger Chemists were able to insights that worked for her: being self- schedule) and finally, compromise. share details about their leadership struc- ish with family time, mixing priorities These insights were well received and ture, organization, and successful events (Allison did this by combining her love the audience had many questions and and initiatives. The Government Affairs of biking with her morning commute), observations to share. Committee was able to give feedback saying “no” but offering alternatives At the end of the day, Allison ex- about how ACS can improve their pol- when asked to do extra work (for exam- pressed her pleasure at being able to icy and advocacy webpage and make it meet so many members of NESACS more accessible to members. Allison’s and was very impressed by their enthu- siasm and engagement, especially from goal is to provide a start-up kit for mem- u bers to better prepare for congressional our younger chemists! visits and to engage the ACS commu- nity in science policy. Allison was very receptive to new ideas and it made for a fruitful and productive discussion.

4 The Nucleus March 2017 Monthly Meeting Biography: Gabor A. Somorjai was born in Bu- The 968th Meeting of the Northeastern Section of the American dapest, Hungary, on May 4, 1935. He was a fourth year student of Chemical Chemical Society Engineering at the Technical University 2016 Richards Medal Award Meeting in Budapest in 1956 at the outbreak of Thursday, March 23, 2017 the Hungarian Revolution. He left Hun- gary and immigrated to the United Harvard University States, where he received his Ph.D. de- Cambridge, MA gree in Chemistry from the University 5:30 pm Social Hour (Loeb House) of California, Berkeley in 1960. He be- came a U.S. citizen in 1962. 6:15 pm Dinner (Loeb House) After graduation, he joined the IBM 8:15 pm Richards Medal Award Ceremony research staff in Yorktown Heights, New Mallinckrodt Building, Pfizer Lecture Hall - MB23, York, where he remained until 1964. At 12 Oxford Street, Cambridge, MA. that time, he was appointed Assistant Leland L. Johnson Jr., NESACS Chair, Presiding Professor of Chemistry at the University of California, Berkeley. In 1967, he was Reflections on Theodore William Richards named Associate Professor, and in 1972 Introduction of the 41st Richards Medalist promoted to Professor. Concurrent with his faculty appointment, he is also a Fac- 2016 Richards Medalist ulty Senior Scientist in the Materials Professor Gabor A. Somojai, Department of Chemistry, University Sciences Division, and Director of the of California, Berkeley and Lawrence Berkeley National Labora- Surface Science and Catalysis Program tory at the Center for Advanced Materials, at Address: The Surface Science Approach to Molecular Catalysis. the Lawrence Berkeley National Labo- Transition from Studies of Crystal Surfaces in Vacuum to High continued on page 13 Pressure and Liquid Phase Heterogeneous, Homogeneous and Enzyme Nanoparticle Catalysis Abstract: YOU MUST REGISTER IN ADVANCE TO ATTEND THE MEETING: DINNER RESERVATIONS ARE REQUIRED. The surface science of chemical reactiv- ity utilized single crystal surfaces to de- THE PUBLIC IS INVITED termine the atomic structures at inter- • For those who would like to join us for dinner, register by noon, Thursday, faces responsible for rearrangements of March 16, using Eventbrite. molecules through changes at covalent • To register, please use the link at: http://www.nesacs.eventbrite.com/ or charge transfer (acid-base) bonds. • Cost: Members, $30; Non-members, $35; Retirees, $20; Stu dents, $10. Dinner The evolution of nanomaterials science reservations not cancelled at least 24 hours in advance must be paid. has had a large impact on molecular catalysis science since most heteroge- • If you wish to join us for this meeting and not eat dinner, please register by neous, homogeneous and enzyme cata- noon, Thursday, March 17, using the Eventbrite link above. lysts are nanoparticles in the 0.8-10 nm • New members or those seeking additional information, contact the NESACS range. Monometallic and bimetallic administrative coordinator, Anna Singer, at [email protected] or at (781) nanoparticles as well as core-shell struc- 272-1966 during regular business hours only. tures and oxide-metal interfaces are • Please note: the office is open on a part-time basis only used to study multipath catalytic reac- Anyone who needs special services or transportation, please call Anna Singer a tions with high product selectivity. At few days in advance so that suitable arrangements can be made. Free parking in the same time instruments were devel- the Broadway St. Garage (3rd level or higher), enter from Cambridge Street via oped that can be employed to study cat- u Felton, St. alysts under reaction conditions to mon- itor dynamic changes that occur during catalytic reactions, their atomic and mo- lecular structure, and composition and oxidation state with high spatial and time resolution. These in-situ surface continued on page 13

The Nucleus March 2017 5 Richards Award Address Molecular Catalysis Science. The Development of Surface Science toward Integration of Heterogeneous, Homogeneous, and Enzyme Catalysis on the Nanoscale Gabor A. Somorjai University of California, Berkeley, and Lawrence Berkeley National Laboratory, Berkeley, California 94720 My adventure into this field followed of metal nanoparticles affect most cat- Heterogeneous Catalysis the transformation from investigating alytic reaction rates and selectivities.6a As the sizes of nanoparticles change single crystal surfaces in vacuum and Most reactions, including the hydrogena- from 2 nm toward 0.8 nm, the electronic high pressures and at the liquid phase,1 tion reactions of benzene, cyclohexene, structure and oxidation states of these to the development of the molecular sci- crotonaldehyde, pyrrole, pyrene, and fur- nanoparticles change as well, as indi- ence in all three fields of catalysis, het- fural, are multi-path.8 It was found that cated by XPS studies.12 Rhodium or erogeneous, homogeneous and enzyme the turnover rates and selectivities are platinum nanoparticles change their ox- that I am attempting to integrate.2 Much particle size dependent. For example, idation states from metallic to oxide of the surface science of catalysis started CO hydrogenation, commonly called rhodium 3+ or platinum 2+ and 4+ as with metal single crystals, mostly plat- Fischer-Tropsch synthesis, shows a 5- the nanoparticle size is changed. Calcu- inum, which was the granddaddy of all fold increase in turnover rates as the lations by Norskov et al clearly indicate catalysts, discovered in the beginning of cobalt catalyst nanoparticle size changes that when oxygen is adsorbed on gold or the 19th Century. Low energy electron from 3 to 11 nanometers.9 Methylcy- platinum nanoparticles, the oxygen re- diffraction showed different types of clopentane isomerization shows size and moves electrons from the metal nan- single crystal surfaces of platinum; e.g., shape dependence of the nanoparticles.10 oclusters, which then become oxides.13 hexagonal, square, or stepped crystal The question that naturally arises is When the small transition metal surfaces with periodic steps and kinks.3 “why are the catalytic selectivity and nanoparticles are encapsulated by den- Molecular beam scattering in the 1970s turnover rates of metal nanoparticles drimers, the high oxidation state is discovered that stepped surfaces can size and shape sensitive?” maintained and these nanoparticles can perform H2/D2 exchange with high carry out homogeneous catalytic reac- 4 Atomic Level Characterization probability. On the other hand, the de- tions as shown in many examples by under Reaction Conditions 14 fect-free flat surfaces do not break H-H Dendrimer-en- In-situ surface techniques, mostly prac- Toste and Somorjai. bonds, where such bond breaking is capsulated nanoparticles with very small 5 ticed using the synchrotron, can be used below the detection limit. More studies size carry out electrophilic reactions to identify the size and shape depend- of bond breaking revealed not only H-H (e.g. hydroformylation and decarbony- ence of reaction rates and selectivities of chemical bonds but also C-H, O-O, C- lation) in a solution phase, similar to catalytic reactions. Sum frequency gen- O, and that C-C bonds can be broken at transition metal ions. Transition metal eration vibrational spectroscopy, high these low coordination sites at steps and nanoclusters can carry out single metal 1 pressure scanning tunneling microscopy, kinks of surfaces. ion-like catalytic reactions. and synchrotron techniques, including Making a big jump in chemistry to ambient pressure X-Ray Photoelectron Oxide-Metal Interfaces as Active nanoparticles, it was found that most Spectroscopy (APXPS), extended X-ray Sites for Acid-Base Catalysis: Cro- catalysts are in nanoparticle dimensions. absorption fine structure, and Infrared tonaldehyde Hydrogenation as an Metal Nanoparticles and Meso- and X-ray microspectroscopy, reveal Example porous Oxide Synthesis how the size and shape of catalysts con- When platinum is supported on SiO2 or Colloidal synthesis of nanoparticles trol reaction rates and selectivities. titanium oxide mesoporous support, the starting with ionic salts, surfactant sol- Many bimetallic nanoparticles with var- product distribution of crotonaldehyde vents, and reducing agents can produce ious sizes and shapes show that a com- hydrogenation dramatically changes. nanoparticles from 1-10 nm in size.6 position change is driven by a change in On titanium oxide many products from Oxide supports for the transition metal chemical and oxidizing environments of crotonaldehyde, including butanol, cro- nanoparticles are frequently utilized. these nanoparticles.11 High pressure ton alcohol, butyl aldehyde, and propy- The mesoporous inorganic oxide shells scanning tunneling microscopy shows lene are formed; while on platinum enable high temperature catalytic oxida- the adsorbate mobility under reaction supported in SiO2 the only product is tion studies.7 conditions. The adsorbates restructure butyl aldehyde. This process, which Metal Nanoparticles’ Size Depend- the metal surfaces, and this is enhanced changes the product distribution by ent Covalent Bond Catalysis at high reactant pressures. changing the support, which alone does Metal nanoparticles in the size range of Changing the Oxidation States of not carry out reactions, changes the cat- 1 to 10 nm are produced with very well- Nanoparticles with Decreasing Size alytic activity of group VIII transition metals of iron, nickel, rhodium, palla- defined size control. The size and shape — Conversion of Homogeneous to continued on page 7

6 The Nucleus March 2017 Richards Award the potential between the metal and the oligomer-protein conjugate results in the oxide interface. These electron flows oriented display of aldolase on the glass Continued from page 6 between an oxide and a metal interface surface.18 Taking advantage of the dium, and iridium. The supports that ionizes molecules and they are com- transparent nature of the glass surfaces change the catalytic activity are titanium monly called acid-base catalysis phe- used in these studies, we are also seek- oxide, cerium oxide, and niobium oxide. nomena. When the platinum is sup- ing to characterize these surfaces using This phenomenon, frequently called ported by various oxides, ranging from alternative spectroscopic techniques, SMSI or strong metal support interac- silica to zirconium oxide, the isomeriza- such as sum frequency generation and tion, is related to the electron flow be- tion activity of n-hexane is controlled by X-ray photoelectron spectroscopy, to tween the transition metal and the oxide the oxide metal interface charge flow. gain information about the orientation support under reaction conditions.15 Hybrid Systems. Hybridized En- and coverage or the protein. Similar The fundamental reasons for this zymes to Immobilize onto Glass studies are carried out by adsorbing on process have been studied, and it is glass surfaces dehydrogenase enzymes caused by the electron flow between the Enzymes are able to maintain remark- ably high selectivity towards their sub- that oxidize alcohol to aldehydes and transition metal and the oxide support. aldehydes to acids, respectively. It is also called “hot electron flow.” The strates while still retaining high catalytic Integration of the Three Fields of electrons in the transition metal are ex- rates. By immobilizing enzymes onto Cat alysis (Heterogeneous, Homoge- cited when an exothermic catalytic re- surfaces we can heterogenize these bio- neous and Enzyme ) — Future action or photons produce an electron logical catalysts, making it practical to Promise flow, which is observed by carbon study, use, and combine them in an eas- monoxide oxidation or hydrogen oxida- ily controlled system. We have devel- In our attempt to focus on the chemical tion reactions.16 When an oxide metal oped a platform that allows for the correlations between the three groups interface is constructed, often called a simple and oriented immobilization of (heterogeneous, homogeneous and en- proteins through DNA directed immobi- zymatic) the future looks very promis- Schottky barrier, with a metal layer of a 18 We use DDI to deposit nanometer-range thickness on a transi- lization (DDI). ing for molecular catalysis science enzymes onto glass slides. This is done tion metal oxide surface, the electrons studies. Catalysis of heterogeneous, ho- through bottom-up assembly of two sep- flow from the metal to the oxide. The mogenous and enzymatic origin alike arate components. The first is coupling electron flow ionizes the reacting mole- involve nano-sized materials. These - an aldolase DNA to aniline functional- nanocatalysts comprise organic and in- cules. In the case of CO oxidation CO2 ized glass slides. In tandem, aldolase is forms, and in the case of hydrogen oxi- organic components. Charge, coordina- - 17 modified at the N-terminus with a com- tion, interatomic distance, bonding, and dation H2O forms. These are the elec- plimentary DNA strand, also substituted trons that can be detected by applying orientation of catalytically active atoms with the aminophenol coupling partner. are molecular factors shared by all three The subsequent hybridization of the sur- fields of catalysis. By controlling the face oligomer with the complementary governing catalytic components and the continued on page 12

The Nucleus March 2017 7 Announcements

The Norris-Richards 2017 Philip Levins Undergraduate Summer Research Scholarships Esselen Memorial March 24, 2017 Deadline The Northeastern Section of the Ameri- Award to Prize can Chemical Society established the James Flack Norris and Theodore Nominations for the Philip L. Levins William Richards Undergraduate Sum- Neil M. Memorial Prize for outstanding per- mer Scholarships to honor the memories formance by a graduate student on the of Professors Norris and Richards by Donahue way to a career in chemical science promoting research interactions between should be sent to the NESACS Admin- undergraduate students and faculty. Prof. Neil M. Donahue, Lord Professor istrative Secretary, 12 Corcoran Rd., Research awards of $3500 will be of Chemistry; Departments of Chem- Burlington MA 01803 by March 24, given for the summer of 2017. The stu- istry, Chemical Engineering, and Engi- 2017. dent stipend is $3000 for a minimum neering and Public Policy and Director The graduate student’s research commitment of ten weeks of full-time of the Steinbrenner Institute for Envi- should be in the area of organic analyti- research work. The remaining $500 of ronmental Education and Research will cal chemistry and may include other the award can be spent on supplies, receive the 2017 Esselen Award for areas of organic analytical chemistry travel, and other items relevant to the Chemistry in the Public Interest. such as environmental analysis, bio- student project. The award will be presented to Pro- chemical analysis, or polymer analysis. Institutions whose student/faculty fessor Donahue at the April Monthly Research emphasis must be on novel team receives a Norris/Richards Under- Meeting to be held on April 27, 2017 at uses of analytical methods, not routine graduate Summer Research Scholarship the Harvard Faculty Club. analysis. are expected to contribute toward the The title of his talk is: Atmospheric Nominations may be made by a support of the faculty members and to Ozonolysis: From Collisional Energy faculty member, or the student may sub- waive any student fees for summer re- Transfer to Particle Physics and Every- mit an application. A biographical u search. Academic credit may be granted thing in Between sketch, transcript of graduate and under- to the students at the discretion of the in- graduate grades, a description of present stitutions. research activity and three references use. Award winners are required to sub- must be included, one of which must be mit a report (~5-7 double-spaced pages • feasibility - evidence must be pro- from the student’s research advisor. The including figures, tables, and bibliogra- vided to demonstrate that the project nomination should be specific concern- phy) of their summer projects to the NE- can be completed by you in the time ing the contribution the student has SACS Education Committee by October available and with the facilities at made to the research and publications (if 20, 2017 for publication in The Nucleus. your disposal. any) with multiple authors. They are also required to participate in • preparation - your academic record, The award of $750.00 and a con- the Northeast Student Chemistry Re- your ability to handle the project, and gratulatory citation will be presented at u search Conference (NSCRC) in April the background study you have made the May 2017 NESACS meeting. 2017. on your research problem will be taken into consideration. Eligibility: (PDF format) are strongly preferred. Applications will be accepted from stu- • commitment - the depth of your com- Applicants will be notified of the dent/faculty teams at colleges and uni- mitment, and that of your department, results by email by April 21, 2017, with versities within the Northeastern Section. faculty, and institution to independent written confirmation to follow. The undergraduate student must be a research as a vital component of sci- ence education will be assessed. Selection Committee Chair: chemistry, biochemistry, chemical engi- Professor Jonathan Rochford neering, or molecular biology major in Application for 2017: Department of Chemistry good standing, and have completed at • Announcement Letter University of Massachusetts Boston least two full years of college-level • Instructions 100 Morrissey Boulevard chemistry by Summer, 2018. Boston, MA 02125-3393 • Student Application Form u Criteria for Selection: • Faculty Information Form Email: [email protected] • scientific merit - important factors in- clude the originality of the project, the Completed applications are to be sub- depth of the investigation, the signif- mitted no later than March 24, 2017, to icance of the scientific questions you the Chair of the Selection Committee. pose, and the methods you propose to Please note that applications via email 8 The Nucleus March 2017 2017 Cynthia Friend, David Walt NESACS to Receive ACS Awards

Candidates Cynthia M. Friend, T.W. Richards Professor of Chemistry at Harvard University, and David R. Walt, Howard Hughes Medical Institute Professor at Tufts University, for Election will receive 2017 ACS Awards on Tuesday, April 4, 2017, at the ACS national meet- ing in San Francisco, according to the announcement in the January 2nd issue of Chair- Elect C&EN. Raj (SB) Rajur Andrew Scholte Secretary Michael Singer Trustee Ruth Tanner Robert Lichter Auditor Patrick Gordon Councilor / Alternate Councilor Michael P. Filosa Pam Mabrouk Morton Z. Hoffman Matthew M. Jacobsen Patrick M. Gordon Carol Mulrooney Robert Lichter Raymond E. Borg Ajay Purohit June Lum Sonja Strah-Pleynet Mukund S. Chorghade Cynthia M. Friend Photo credit: Robert Madix David R. Walt Photo credit: Tufts University Raj (SB) Rajur Anna Sromek Professor Friend is the winner of the Professor Walt will receive the Kathryn Andrew Scholte ACS Award in Surface Chemistry, spon- C. Hach Award for Entrepreneurial Suc- Sofia Santos sored by the ACS Division of Colloid & cess, sponsored by the Kathryn C. Hach Director-at-Large Surface Chemistry, for her “paradig- Award Fund, for “inventing and com- Ralph Scannell matic developments in the mechanistic mercializing microwell arrays that ben- Jens Breffke understanding of oxygen-assisted cat- efit research, medicine, and agriculture John M. Burke alytic cycles on gold surfaces and their with tremendous impact on the econ- Jim Piper implementation to nanoporous gold cat- omy through job and value creation.” Nominating Committee alysts under realistic conditions.” A col- He cites George Whitesides of Harvard Sonja Strah-Pleynet league from the University of Washing- University, who was his postdoctoral Caitlyn Mills ton said about her work, “Professor mentor, as “a stalwart supporter and Thomas R. Gilbert Friend has distinguished herself by in- friend for over three decades,” from Richards Award Committee novative surface science research, plus whom he learned how to look outside of exemplary leadership in, service to, and his narrow field for interesting and im- Jerry Jasinski u Ravi Sharma teaching of this field.” portant problems. Malika Jeffries-EL Esselen Award Committee Prakash Rai Join What’s Yours? Robert Hanson Many local employers post positions Doris Lewis NESACS on the NESACS job board. Petition Candidates: Any group comprising 2 per cent or more of on facebook Find yours at the Northeastern Section may nom- www.nesacs.org/jobs inate candidates…” See NESACS www.facebook.com/nesacs website for details. u

The Nucleus March 2017 9 STEM Journey IV: NASA’s Mission to Mars Free Admission Saturday March 4, 2017 Sandwich High School/STEM Academy Noon to 4 PM Introduction by Dr. Peter Dorhout, President Elect, AmericanChemicalSociety KeynoteSpeaker: Dr. Luke Roberson, SeniorScientist NASA, Cape Canaveral Preregister at fb.me/stemjourney

Presented by: * Cape and Islands Council of the Boy Scouts of America * Northeastern Section of the American Chemical Society * Sandwich High School/STEM Academy *PID Analyzers,LLC

10 The Nucleus March 2017 STEM Journey III –Transportation: Air, Land and Sea

By Jack Driscoll and Jennifer Maclachlan. Edited for The Nucleus by Michael Filosa STEM Journey III was held on April 2, NSF Career Award (1998) and the King- Dan serves on a number of boards 2016 at Cape Cod Community College. Sun Fu Memorial Best Transactions on including the Regional Airline Associa- The event was attended by 1400 enthu- Robotics Paper Award (2006). He is an tion, the Cape Cod Business Round siastic participants which was up 27 % IEEE Fellow (2014). He teaches a Table, the Association for the Preserva- from Stem Journey II. The number of course on Autonomous Cars at MIT. tion of Cape Cod. Under Dan’s leader- exhibitors was up from 30 to 47 and 70 Air: ship Cape Air has received recognition Boy Scout Merit Badges were earned. for being one of the most philanthropic The theme was transportation. companies in southeastern Massachu- Transportation was then divided into setts. In June of 2010 Dan received an three sections: Land, Sea and Air. honorary doctorate degree from Daniel Land: Webster College in Nashua, New Hampshire. Sea:

The Air Section keynote speaker was, Daniel A. Wolf, Massachusetts State Senator and founder of Cape Air. He talk was titled “Advances in Aviation.” Daniel Wolf founded Cape Air in The Land Section keynote speaker was, 1989 with one route between Boston Dr. John J. Leonard, Samuel C. Collins and Provincetown, eight employees and Professor of Mechanical and Ocean En- a first year total of 8,000 passengers. The Sea Section keynote speaker was gineering and Associate Deparment Today, Cape Air, along with sister Kaitlyn Tradd, Research Engineer, Ap- Head for Research at the Massachusetts airline Nantucket Airlines, is the largest plied Ocean Physics and Engineering Institute of Technology. He is also a commuter airline in the United States. Department, Woods Hole Oceano- member of the MIT Computer Science Cape Air/Nantucket Airlines’ fleet of graphic Institute (WHOI). Her talk was and Artificial Intelligence Laboratory Cessna 402s, Cessna Caravan Amphib- titled “Underwater Vehicles-Human Oc- (CSAIL). Prof. Leonard’s research ad- ians, Britten-Norman Islanders and cupied, Remotely Operated and Au- dresses the problems of navigation and ATR-42s fly to some of the most beau- tonomous.” mapping for autonomous mobile robots. tiful destinations in the world. Cape Kaitlyn’s work at WHOI has His talk was entitled “Autonomous Air/Nantucket Airlines is partly an em- spanned numerous endeavors: the me- Cars.” ployee-owned company with a work- chanical design and structural analysis He holds the degrees of B.S.E.E. in force of approximately 1,200 serving of the recent Human Occupied Vehicle Electrical Engineering and Science from more than 686,000 passengers a year. (HOV) Alvin upgrade project, several the University of Pennsylvania (1987) Dan received a bachelor’s degree in scientific research cruises with Re- and D.Phil. in Engineering Science from Political Philosophy from Wesleyan motely Operated Vehicle (ROV) Jason the University of Oxford (1994). Prof. University in Middletown, Connecticut II, and the Autonomous Underwater Ve- Leonard joined the MIT faculty in 1996, and a degree at the Quaker City School hicle (AUV) Sentry, and a multitude of after five years as a Post-Doctoral Fel- of Aeronautics in Airframe and Power smaller-scale engineering projects in- low and Research Scientist in the MIT Plant Maintenance. Dan continues to volving many of WHOI’s submersible Sea Grant Autonomous Underwater Ve- stay current with his Air Transport Pilot vehicles. hicle (AUV) Laboratory. license and flies as a pilot for Cape Air She is currently working on the de- He was team leader for MIT’s on weekends during the busy summer sign of a new vertically profiling au- DARPA Urban Challenge team (robotic season. tonomous vehicle for global ocean vehicles), which was one of six teams to In November 2010, 2012 and 2014, biogeochemical mapping, while contin- complete the race. He served as Co-Di- Dan was elected to the Massachusetts uing work in support of the various ex- rector of the Ford-MIT Alliance from State Senate representing Cape Cod and isting underwater vehicles, helping to 2009 to 2013. He is the recipient of an the Islands. continued on page 12 The Nucleus March 2017 11 Richards Award (3) Lyon, H. B.; Somorjai, G. A. J. Stem Journey III Chem. Phys. 1967, 46, 2539. Continued from page 7 Continued from page 11 (4) Salmeron, M.; Gale, R. J.; Somor- molecular factors, catalytic processes of jai, G. A. J. Chem. Phys. 1977, 67, further scientific achievements at multichannel and multiproduct nature 5324. WHOI. could be run in all three catalytic plat- (5) Salmeron, M.; Gale, R. J.; Somor- Kaitlyn first became interested in forms to create unique end products. jai, G. A. J. Chem. Phys. 1979, 70, ocean exploration as a child when she This is the promise of molecularly uni- 2807. climbed inside of a mock-up of the fied catalytic scheme of the future. (6) (a) Song, H.; Kim, F.; Connor, S.; Alvin personnel sphere, which still is in Acknowledgements: Somorjai, G. A.; Yang, P. J. Phys. residence at the exhibit center today. In high school, she attended Nitsch Engi- Our catalysis research is supported by Chem. B 2005, 109, 188; (b) Tsung, neering’s “Introduce a Girl to Engineer- supported by the Director, Office of Sci- C.-K.; Kuhn, J. N.; Huang, W.; ing Day” at Logan Airport and set her ence, Office of Basic Energy Sciences, Aliaga, C.; Hung, L.-I.; Somorjai, sights on a career as an engineer. Chemical Sciences, Geosciences and G. A.; Yang, P. J. Am. Chem. Soc. Biosciences Division of the US Depart- 2009, 131, 5816. Exhibitors (Partial Listing): ment of Energy under Contract No. De- (7) Joo, S. H.; Park, J. Y.; Tsung, C.-K.; • NOAA Outreach and Education on AC02-05CH11231. The synthesis and Yamada, Y.; Yang, P.; Somorjai, G. Protected Species Program Director A. Nat. Mater. 2009, 8, 126. instrumentation research is supported by • Kiting USA the Director, Office of Science, Office (8) An, K.; Somorjai, G. A. Chem- • Cambridge Science Festival of Basic Energy Sciences, Materials Sci- CatChem 2012, 4, 1512. ences and Engineering Division, of the (9) Melaet, G.; Lindeman, A.; Somor- • Science on the Street U.S. Department of Energy under Con- jai, G. Top. Catal. 2014, 57, 500. • Zephyr Education Foundation tract No. DE-AC02-05-CH11231. (10)Alayoglu, S.; Aliaga, C.; Sprung, • Northeastern Section of the American References: C.; Somorjai, G. A. Catal. Lett. Chemical Society (1) Somorjai, G. A.; Li, Y. Introduction 2011, 141, 914. • American Chemical Society to Surface Chemistry and Catalysis, (11) Tao, F.; Grass, M. E.; Zhang, Y.; Butcher, D. R.; Renzas, J. R.; Liu, • 4C STEM Club (Cape Cod Commu- 2nd Edition; Wiley, 2010. nity College) (2) Ye, R.; Hurlburt, T. J.; Sabyrov, K.; Z.; Chung, J. Y.; Mun, B. S.; Salmeron, M.; Somorjai, G. A. Sci- • South Shore YMCA - Camp Burgess Alayoglu, S.; Somorjai, G. A. Proc. & Hayward Natl. Acad. Sci. U. S. A. 2016, 113, ence 2008, 322, 932. • The Hundred Acre School at Heritage 5159. continued on page 14 Museums & Gardens • North Atlantic Archaeology Collabo- rative • National Marine Life Center • Cape Cod Maritime Museum • Falmouth Public Schools • Cape Light Compact • Chatham Marconi Maritime Center • Waquoit Bay Science School • Mashpee Middle/High School • Cape Cod Makers • Cape Cod Museum of Natural History • Monomoy Regional High School • Thornton W. Burgess Society • Waquoit Bay National Estuarine Re- search Reserve • Kurt Giessler Foundation for Youth Achievement • Oceaneering International • Upper Cape Cod Regional Technical School u • Saint Margaret Regional School

12 The Nucleus March 2017 Biography Adventures in Proofreading Continued from page 5 ratory. He was appointed University By Donald O. Rickter Professor by the UC Board of Regents Note from the Editor: Don Rickter mentioned to me several months ago that he was in March of 2002. busy writing a memoir. I enthusiastically encouraged him to send me excerpts for Professor Somorjai has educated publication in the Nucleus. This piece is the first of what I hope are many submis- 140 Ph.D. students and more than 250 sions from Don, who has been a key contributor and resource for the Nucleus and postdoctoral fellows, about 100 of its editors for many years. whom hold faculty positions and many The story began in Yolo County, CA, penpal relationship when we learned more are leaders in industry, He is the when I was a teen-ager. Our major that our mothers were both involved in author of more than 1200 scientific pa- newspaper, The Woodland Daily Demo- the repercussions of the San Francisco pers in the fields of surface chemistry, crat, published an annual edition honor- Fire of 1906. heterogeneous catalysis, and solid state ing Mexican Independence Day, Most authors of books that sell well chemistry. He has written three text- September 16. At the top of each page do not appreciate my helpful sugges- books, Principles of Surface Chemistry, were displayed the crossed flags of the tions. An exception is Doris Kearns Prentice Hall, 1972; Chemistry in Two US and Mexico — but they were back- Goodwin. She has written outstanding Dimensions: Surfaces, Cornell Univer- ward. According to the Flag Code, the books that seem to be flawless. Deep in sity Press, 1981; Introduction to Surface US flag should have been on its right the interior of The Bully Pulpit is a very Chemistry and Catalysis, Wiley-Inter- (the viewer’s left). I wrote to the news- embarrassing misprint. When I wrote to science, 1994 and Introduction to Sur- paper. My letter was printed, with my Ms. Goodwin she immediately sent a face Chemistry and Catalysis, Second nom de plume, Thaddeus Stribling, and gracious thank you note. Edition, Wiley 2010; and a monograph, an apology from the editor: “Our sharp- Greg Mortenson, in his Three Cups Adsorbed Monolayers on Solid Sur- u eyed reader in Davis is correct.” of Tea (2007), surprised me by mis- faces, Springer-Verlag, 1979. When I was an undergraduate at spelling the Marriott, where he stayed UC-Davis, I checked punctuation and for a period, many times on a few pages. Abstract spelling for the weekly “Cal Aggie.” I Two books seem to be free of prob- was too busy in graduate school and in lems. Senator Elizabeth Warren wrote A Continued from page 5 the Navy to do more. Fighting Chance (2014) with no obvi- techniques include sum frequency gen- Years later, while at Polaroid in ous flaws in the text, but a photo caption eration vibrational spectroscopy, high Cambridge, MA, I volunteered to help said “we’re dying (sic) Easter eggs.” I pressure scanning tunneling microscopy with The Nucleus. Myke Simon and was astounded to find J.K. Rowling’s along with synchrotron techniques of X- Arno Heyn were my mentors. Their The Casual Vacancy (2012) had “dying ray spectroscopies. Discoveries have in- monthly conferences included detailed (sic) her hair jet black” as its only appar- cluded the size and shape dependence of grammatical points. I decided to focus on ent misspelling. turnover rates and product selectivity big items, like the masthead for the Richard Cohen has at least six seri- and other kinetic variables, the impor- Febuary (sic) issue. Many people under- ous errors in his fun book about Nora tance of oxide-metal interfaces in het- stand the intricacies of English better Ephron, She Made Me Laugh (2016). He erogeneous catalysis and the dominance than I do. The most skilled person I have told of Nora’s roots in “Los Angles (sic).” of covalent bond and charged ion chem- known was Vivian Walworth. She was My latest interaction is with a local istry in transition metal and acid-base amazing as a science writer and editor — Pulitzer Prize winning author, Megan catalysis. Below 2 nm the metal and as a human being. Marshall. Her biography, Elizabeth nanoparticles have electronic structures I do what I can’t help doing; my Bishop, A Miracle for Breakfast, is due that stabilize charge states, which can be eyes spot misspellings in books. I turn out on 7 February. I caught a notice on used to heterogenize homogeneous cat- the page and an atrocity leaps out at me. Meg’s website that highlighted the word alysts. Enzymes can be immobilized on This should not happen with spell check Brakfast (sic). She generously sent me a DNA to aniline functionalized glass and numerous professional proofread- an autographed copy of the book in Jan- and they maintain most of their catalytic ers. Yet it happens. Laurie R. King, au- uary. activity in this mode. Our aim is inte- thor of The Beekeeper’s Apprentice, has My eyes automatically react to un- gration of the three fields of catalysis, written fourteen books about Sherlock expected flaws. Newspapers, TV, and heterogeneous, homogeneous and en- Holmes and his companion, Mary Rus- the web are problems because errors of zyme by developing hybrid systems and sell. One book told of their voyage from content and style are too numerous to new instruments that permit studies of u England to India crossing the Dead Sea. deal with. I try to read for pleasure. I am increased catalytic complexity. Of course it was the Red Sea. I grateful for the authors and editors who wrote the author. She replied soon, with dedicate themselves to preserving truth the comment that ten pairs of eyes read and good stuff. u the text before publication. We began a © Donald Rickter 2016, 2017

The Nucleus March 2017 13 BUSINESS DIRECTORY Richards Award SERVICES SERVICES Continued from page 12 (12) Li, Y.; Liu, J. H.-C.; Witham, C. A.; Huang, W.; Marcus, M. A.; Fakra, S. C.; Alayoglu, P.; Zhu, Z.; Thomp- son, C. M.; Arjun, A.; Lee, K.; Gross, E.; Toste, F. D.; Somorjai, G. A. J. Am. Chem. Soc. 2011, 133, 13527. (13)Kleis, J.; Greeley, J.; Romero, N. A.; Morozov, V. A.; Falsig, H.; Larsen, A. H.; Lu, J.; Mortensen, J. J.; Dułak, M.; Thygesen, K. S.; Nørskov, J. K.; Jacobsen, K. W. Catal. Lett. 2011, 141, 1067. (14)(a) Witham, C. A.; Huang, W.; Tsung, C.-K.; Kuhn, J. N.; Somor- jai, G. A.; Toste, F. D. Nat. Chem. 2010, 2, 36; (b) Gross, E.; Liu, J. H.-C.; Toste, F. D.; Somorjai, G. A. Nat. Chem. 2012, 4, 947; (c) Gross, E.; Shu, X.-Z.; Alayoglu, S.; Bech- tel, H. A.; Martin, M. C.; Toste, F. D.; Somorjai, G. A. J. Am. Chem. Soc. 2014, 136, 3624; (d) Ye, R.; Yuan, B.; Zhao, J.; Ralston, W. T.; Wu, C.-Y.; Unel Barin, E.; Toste, F. D.; Somorjai, G. A. J. Am. Chem. Soc. 2016, 138, 8533. (15) Tauster, S. J.; Fung, S. C.; Baker, R. T. K.; Horsley, J. A. Science 1981, 211, 1121. (16) (a) Park, J. Y.; Baker, L. R.; Somor- jai, G. A. Chem. Rev. 2015, 115, 2781; (b) Park, J. Y.; Somorjai, G. New A. J. Vac. Sci. Technol. B 2006, 24, 1967. Members (17) Hervier, A.; Renzas, J. R.; Park, J. Y.; Somorjai, G. A. Nano Lett. 2009, 9, 3930. Invitation to attend a (18) Palla, K. S.; Hurlburt, T.; Buyanin, meeting A.; Somorjai, G. A.; Francis, M. B. u You are cordially invited to attend J. Am. Chem. Soc. 2016. one of our upcoming Section meet- ings as a guest of the Section at the social hour and dinner preceding the meeting. Looking for seminars Please contact Anna Singer at [email protected], (preferred), or in the Boston area? phone/fax 781-272-1966 be tween the u Check out the hours of 9am and 6pm. NESACS Calendar www.nesacs.org/seminars

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