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Molecular Markers on early and Metastatic Disease: What should be ordered and what are their prognostic and predictive roles? 3rd Invitation Satellite Symposium on G.I. Cancer Sao Paulo Brazil 8/7/19 Immunotherapy in MSI-H colorectal cancer: What is the best sequence? How to select drugs and combinations? Satellite Symposium on G.I. Cancer Sao Paulo Brazil 8/8/19 Liquid biopsies or new developments. Satellite Symposium on G.I. Cancer Sao Paulo Brazil 8/9/19 Continuum of Care in RASwt Metastatic Colorectal Cancer. “ConCiencia” Mendoza Argentina 8/22/19 LATAM Multikinase Inhibitors mCRC. Barcelona. 9/26/2019 Molecular Landscape of mCRC. Grand Rounds. Emory University. Atlanta, 9/11/2019 Mechanisms of Action of Regorafenib. Satellite Symposium, ESMO, Barcelona, 9/28/2019 Next Generation Sequencing in mCRC: Novel Mutated Genes and their effect on response to therapy. Oral presentation at ESMO 9/30/2019, Barcelona, Spain.

H. Bibliography:

Peer Reviewed 1. Jaschonek K, Einsele H, Schmitt H, Lenz H-J, Ehninger G: 8-Methoxypsoralen and ultraviolet A therapy for cutaneous manifestations of graft-versus-host disease. Lancet, 1:599, 1988. 2. Ehninger G, Lenz H-J: Stand der intraperitonealen chemotherapie. Z Gastroenterol Verh, 24:196–198, 1989. 3. Lenz H-J, Brunner T, Dopfer R, Schlag H, Ehninger G: Kontinuierliche infusion von natürlichem interleukin-2 zur behandlung maligner erkrankungen: phase I studie. Onkologie, 13:429–433, 1990. 4. Lenz H-J, Jaschonek K, Schuler U, Steinke B, Ehninger G: Splenectomy for chronic thrombotic thrombocytopenic purpura. Lancet 335:1593, 1990. 5. Lenz H-J, Schuler U, Hicking W, Ehninger G: Phase I trial of clebopride: a new antiemetic for induced nausea and vomiting. Eur J Clin Pharmacol, 38:525, 1990. 6. Pawelec G, Schwulera U, Lenz H-J, Owsianowshi M, Bühring HJ, Schlag H, Schneider E, Schaudt K, Ehninger G: Lymphokine release, suppressor cell generation, cell surface markers and cytotoxic activity in cancer patients receiving natural interleukin-2. Molecul Biother, 2:44–49, 1990. 7. Lenz H-J, Schuler U, Jaschonek K, Steinke B, Ehninger G, Waller HD: ZNS- Manifestationen beim metastasierendem mammakarzinom. Tumor Diagnostik und Therapie, 12:177–182, 1991. 8. Lenz H-J, Waller HD: Autoimmune hemolytic anemia in a patient with polycythemia vera: first description. Acta Haematol, 85:111, 1991. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 53 of 173

9. Pawelec G, Lenz H-J, Schneider E, Bühring HJ, Rehbein A, Baumgärtner P, Ehninger G: Clinical trial of natural human lymphocyte-derived interleukin-2 in cancer patients: effects on cytokine production and suppressor cell status. Biotherapy, 3:309–318, 1991. 10. Danenberg PV, Horikoshi T, Volkenandt M, Danenberg K, Lenz H-J, Shea LC, Dicker AP, Simoneau A, Jones PA, Bertino JR: Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s). Nucleic Acids Res, 20:573–579, 1992. 11. Lenz H-J, Schuler U, Hicking W, Ehninger G: Pharmacology of clebopride: a new benzamide derivate. Drug Invest, 4:47–50, 1992. 12. Horikoshi T, Lenz H-J, Danenberg K, Koch O, Bertino JR, Danenberg PV: Quantitation determination of the ratio of a mutated to normal ras genes in the blood of leukemia patients by allele-specific PCR. Leuk Res, 18:693–702, 1994. 13. Koch OM, Probst M, Tiemann M, Jakob I, Volkenandt M, Wienecke R, Buer J, Atzpodien J, Lenz H-J, Danenberg PV, Bertino JR, Parwaresch R: Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphism of rearranged T-cell receptor gamma genes. Br J Haematol, 86:316–321, 1994. 14. Lenz H-J, Danenberg KD, Mano DJ, Danenberg PV: Incorporation of 5- into U2 and U6 snRNA inhibits precursor mRNA splicing. J Biol Chem, 269:31962– 31968, 1994. 15. Lenz H-J, Danenberg KD, Schnieders B, Goeker E, Peters GJ, Garrow T, Shane B, Bertino JR, Danenberg PV: Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncology Res, 6:329–335, 1994. 16. Schmittgen TD, Danenberg KD, Horikoshi T, Lenz H-J, Danenberg PV: Effect of 5- fluoro- and 5-bromouracil-substitution on the translation of human thymidylate synthase mRNA. J Biol Chem, 269:16269–16275, 1994. 17. Banerjee D, Lenz H-J, Schnieders B, Manno DJ, Ju JF, Spears CP, Hochhauser D, Danenberg KD, Danenberg PV, Bertino JR: Transfection of wild type but not mutant p53 induces early monocytic differentiation in HL-60 cells. Cell Growth Differ, 6:1405–1413, 1995. 18. Johnston PG, Lenz H-J, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L: Thymidylate synthase gene and protein expression are associated and correlate with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res, 55:1407–1412, 1995. 19. Leichman L, Lenz H-J, Leichman CG, Groshen S, Danenberg K, Baranda J, Spears CP, Boswell W, Silberman H, Ortega A, Stain S, Beart R, Danenberg P: Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial. Eur J Cancer, 31A:1306–1310, 1995. 20. Lenz H-J, Danenberg KD, Schnieders B, Banerjee D, Bertino JR, Leichman L, Danenberg PV: Identification of mutations by RNA conformational polymorphism “Bar Code” analysis. Genomics, 30:120–122, 1995. 21. Link KH, Kornmann M, Lenz H-J, Butzer U, Pillasch J, Safi F, Gansauge F, Danenberg KD, Danenberg PV, Beger HG: Response prediction in hepatic artery Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 54 of 173

infusion with fluoropyrimidines using cell culture and thymidylate synthase quantitation. Reg Cancer Treat, 8:115–121, 1995. 22. Wang S-J, Scavetta R, Lenz H-J, Danenberg KD, Danenberg PV, Schoenthal AH: Gene amplification and multidrug-resistance induced by the phosphatase-inhibitory tumor promoter okadaic acid. Carcinogenesis, 16:637–641, 1995. 23. Lenz H-J, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen J, Laine L, Crookes P, Silberman J, Baranda J, Garcia Y, Li J, Leichman LP: Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol, 14:176–182, 1996. 24. Formenti SC, Dunnington G, Uziely B, Lenz-H-J, Keren-Rosenberg S, Silberman H, Spicer D, Denk M, Leichman CG, Groshen S, Watkins K, Muggia F, Florentine B, Press M, Danenberg KD, Danenberg P: Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy. Int J Radiat Oncol Biol Phys, 39:1059–1068, 1997. 25. Hayashi K, Metzger R, Salonga D, Danenberg K, Leichman LP, Fink U, Sendler A, Kelsen D, Schwartz G, Groshen S, Lenz H-J, Danenberg PV: High frequency of simultaneous loss of p16 and p16ß gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. Oncogene, 15:1481–1488, 1997. 26. Kornmann M, Link KH, Lenz H-J, Pillasch J, Metzger R, Butzer U, Leder GH, Weindel M, Safi F, Danenberg KD, Beger HG, Danenberg PV: Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett, 118:29–35, 1997. 27. Leichman CG, Lenz H-J, Leichman LP, Danenberg KS, Baranda J, Groshen S, Boswell W, Metzger R, Tan M, Danenberg PV: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion of 5-FU and weekly leucovorin. J Clin Oncol, 15:3223–3229, 1997. 28. Lenz H-J, Leichman CG, Leichman LP, Metzger R, Danenberg KD, Hayashi K, Danenberg PV, Groshen S: Molecular markers as indicators of response and outcome in primary gastric cancer. Prog Gastric Cancer Re, 2:1295–1300, 1997. 29. Ju J, Kane SE, Lenz H-J, Danenberg KD, Chu E, Danenberg PV: Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. Clin Cancer Res 4:2229–2236, 1998. 30. Ju J-F, Banerjee D, Lenz H-J, Danenberg KD, Schmittgen TC, Spears CP, Schonthal AJ, Manno DJ, Hochhauser D, Bertino JR, Danenberg PV: Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. Clin Cancer Res, 4:1315–1322, 1998. 31. Lenz H-J, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Zhou L, Xiong Y-P, Danenberg PV, Leichman LP: p53 and thymidylate synthase expression in untreated stage II colon cancer: association with recurrence, survival, and site. Clin Cancer Res, 4:1227–1234, 1998. 32. Lenz H-J, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, Banerjee D, Bertino JR, Groshen S, Leichman LP, Leichman CG: p53 Point mutations and Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 55 of 173

thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res, 4:1243–1250, 1998. 33. Metzger R, Danenberg K, Leichman CG, Salonga D, Schwartz EL, Wadler S, Lenz H- J, Groshen S, Leichman LP, Danenberg PV: High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin Cancer Res, 4:2371– 2376, 1998. 34. Metzger R, Leichman CG, Danenberg KD, Danenberg PV, Lenz H-J, Hayashi K, Groshen S, Salonga D, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Konda B, Leichman LP: ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination and 5-fluorouracil chemotherapy. J Clin Oncol, 16:309–316, 1998. 35. Yang L, Chiang Y, Lenz H-J, Danenberg KD, Spears CP, Gordon EM, Anderson WF, Parekh D: Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/gancyclovir based gene therapy of human gastrointestinal tumor cells. Hum Gene Ther, 9:719–728, 1998. 36. Brabender J, Lenz H-J, Danenberg PV: Molekulare Marker als Grundlage für die Chemotherapie? Chirurgie, 71:1433–1439, 2000. 37. Ladner RD, Lynch FJ, Groshen S, Xiong Y-P, Sherrod A, Caradonna SJ, Stoehlmacher J, Lenz H-J: dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. Cancer Res, 60:3493–3503, 2000. 38. Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz H- J, Leichman CG, Leichman LP, Diasio RB, Danenberg PV: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase and thymidine phosphorylase. Clin Cancer Res, 6:1322–1327, 2000. 39. Anton PA, Poles MA, Elliott J, Mao SH, McGowan I, Lenz H-J, Chen ISY: Sensitive and reproducible quantitation of mucosal HIV-1 RNA and DNA viral burden in patients with detectable and undetectable plasma viral HIV-1 RNA using endoscopic biopsies. J Virol Methods, 195:65–79, 2001. 40. Garcia AA, Leichman CG, Lenz H-J, Baranda J, Lujan R, Casagrande Y, Leichman LP: Phase II trial of outpatient schedule of in patients with previously untreated metastatic, measurable adenocarcinoma of the stomach. Jpn J Clin Onco,l 31:275–278, 2001. 41. Lara Jr PN, Gandara DR, Longmate J, Gumerlock PH, Lau DHM, Edelman MJ, Gandour-Edwards R, Mack PC, Israel V, Raschko J, Frankel P, Perez EA, Lenz H-J, Doroshow JH: Activity of high-dose toremifene plus cisplatin in platinum-treated non- small-cell lung cancer: a phase II California Cancer Consortium Trial. Cancer Chemother Pharmacol, 48:22–28, 2001. 42. Park DJ, Stoehlmacher J, Zhang W, Tsao-Wei DD, Groshen S, Lenz H-J: A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res, 61:8654–8658, 2001. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 56 of 173

43. Pullarkat ST, Xiong Y-P, Ghaderi V, Stoehlmacher J, Ingles SA, Sherrod A, Warren R, Tsao-Wei D, Groshen S, Lenz H-J: Thymidylate synthase gene polymorphism determines thymidylate synthase mRNA levels and outcome of metastatic colorectal carcinoma treated with 5-fluorouracil. Pharmacogenomics, 1:65–70, 2001. 44. Shirota Y, Stoehlmacher J, Brabender J, Xiong Y-P, Danenberg KD, Groshen S, Tsao- Wei DD, Danenberg PV, Lenz H-J: ERCC1 mRNA levels and thymidylate synthase (TS) mRNA levels predict survival in colorectal cancer patients receiving combination and fluorouracil chemotherapy. J Clin Oncol, 19:4298–4304, 2001. 45. Stoehlmacher J, Ghaderi V, Iqbal S, Groshen S, Tsao-Wei D, Park D, Lenz H-J: A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. Anticancer Res, 21:3075–3080, 2001. 46. Tetef ML, Synold TW, Chow W, Leong L, Margolin K, Morgan R, Raschko J, Shibata S, Somlo G, Yen Y, Groshen S, Johnson K, Lenz H-J, Gandara D, Doroshow JH: Phase I trial of 96-hour continuous infusion of dexrazoxane in patients with advanced malignancies. Clin Cancer Res, 7:1569–1576, 2001. 47. Lenz H-J, Anderson WF, Hall FL, Gordon EM: Clinical protocol. Tumor site specific phase I evaluation of safety and efficacy of hepatic arterial infusion of a matrix-targeted retroviral vector bearing a dominant negative cyclin G1 construct as intervention for colorectal carcinoma metastatic to liver. Hum Gene The,r 13:1515–1537, 2002. 48. Park DJ, Stoehlmacher J, Zhang W, Tsao-Wei D, Groshen S, Lenz H-J: Thymidylate synthase gene polymorphism predicts response to in advanced colorectal cancer. Int J Colorectal Dis, 17:46–49, 2002. 49. Stoehlmacher J, Ingles SA, Park DJ, Zhang W, Lenz H-J: The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma. Oncology Reports, 9:235–238, 2002. 50. Stoehlmacher J, Park DJ, Zhang W, Groshen S, Tsao-Wei DD, Yu MC, Lenz H-J: Association between glutathione s-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. J Natl Cancer Inst, 94:936– 942, 2002. 51. Yen Y, Chow W, Leong L, Margolin K, Morgan R, Raschko J, Shibata S, Somlo G, Twardowski P, Frankel P, Longmate J, Synold T, Newman EM, Lenz HJ, Gandara D, Dorosho JH: Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with : a California Cancer Consortium Trial. Cancer Chemotherapy & Pharmacology, 50(5):353-359, 2002. 52. Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz H-J, Ladner R: A novel SNP within the 5’tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res, 63(11):2898–2904, 2003. 53. Stoehlmacher J, Lenz HJ: Implications of genetic testing in the management of colorectal cancer. Am J Pharmacogenomics, 3(2):73–88, 2003. 54. Park DJ, Zhang W, Stoehlmacher J, Tsao-Wei D, Groshen S, Gil J, Yun J, Sones E, Mallik N, Lenz H-J: ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy. Clinical Advances in Hematology and Oncology, 1(3):162–166, 2003. 55. Hecht JR, Blanke CD, Benson AB 3rd, Lenz H-J: and paclitaxel in Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 57 of 173

metastatic adenocarcinoma of the esophagus and gastric cardia. Oncology (Huntington), 17(9):13–15, 2003. 56. Ramanathan RK, Clark J, Kemeny N, Lenz H-J, Gococo K, Haller D, Mitchell E, Kardinal C: Safety and toxicity analysis of oxaliplatin (Eloxatin™) combined with 5- fluorouracil or as a single agent in more than 5000 patients with previously treated advanced colorectal cancer. J Clin Oncol, 21(15):2904–2911, 2003. 57. Juhasz A, Frankel P, Cheng C, Rivera H, Vishwanath R, Chiu A, Gargolin K, Yen Y, Newman EM, Synold T, Wilczynski S, Lenz H-J, Gandara D, Albain KS, Longmate J, Doroshow JH: Quantification of chemotherapeutic target gene mRNA expression in human breast cancer biopsies: Comparison of real-time reverse transcription-PCR v Relative quantification reverse transcription-PCR utilizing DNA sequencer analysis of PCR products. J Clin Lab Anal, 17(5):184–194, 2003. 58. Zhang W, Lu B, Gil J, Yang D, Groshen S, Lenz H-J: Interleukin-8 (IL-8) promoter region gene polymorphism predicts pelvic recurrence after chemo-radiation in patients with rectal cancer. Int J Radiat Oncol Riol Phys, 57(2):S382, 2003. 59. Lara PN Jr., Frankel P, Mack PC, Gumerlock PH, Galvin I, Martel CL, Longmate J, Doroshow JH, Lenz H-J, Lau DH, Gandara DR: Tirapazamine plus and paclitaxel in advanced malignant solid tumors: a California Cancer Consortium phase I and molecular correlative study. Clin Cancer Res, 9(12):4356–4362, 2003. 60. Lara PN Jr., Quinn DI, Margolin K, Meyers FJ, Longmate J, Frankel P, Mack PC, Turrell C, Valk P, Rao J, Buckley P, Wun T, Gosselin R, Galvin I, Gumerlock PH, Lenz H-J, Doroshow JH, Gandara DR: California Cancer Consortium. SU5416 plus interferon alpha in advanced renal cell carcinoma: a phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition. Clin Cancer Res, 9(13):4772–4781, 2003. 61. Garcia AA, Leichman L, Baranda L, Pandit L, Lenz HJ, Leichman CG. Phase II clinical trail of 5-flourouracil, trimetrexate, and leucovorin (NFL) in patients with advanced pancreatic cancer. Int J Gastrointestinal Cancer, 34(2-3): 79-86, 2003. 62. Stoehlmacher J, Lenz H-J: Cyclooxygenase-2 inhibitors in colorectal cancer. Semin Oncol. 30(3 Suppl 6):10–16, 2003. 63. Stoehlmacher J, Goekkurt E, Lenz HJ. Pharmacogenetic ascpects in treatment of colorectal cancer- an update. Pharmacogenomics, 4(6):767-77, Nov 2003. 64. Whitehead RP, Benedetti JK, Abbruzzese JL, ardalan B, Goodwin JW, Balcerzak SP, Samlowski WE, Lenz H-J, Macdonald JS: A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: A Southwest Oncology Group Study. Investigational New Drugs, 22(3):335–341, 2004. 65. Stoehlmacher J, Park DJ, Zhang W, Yang D, Groshen S, Zahedy S, Lenz HJ: A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5- FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer, 91:344–354, 2004. 66. Lenz HJ. Angiogenesis as a target in colorectal cancer therapy. (Introduction). Sem Oncol, 31(6 Suppl 17):1-2, 2004 67. Iqbal S, Lenz H-J: Integration of novel agents in the treatment of colorectal cancer. Cancer Chemotherapy and Pharmacology, 54(1): S32-S39, 2004. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 58 of 173

68. Iqbal S, Lenz H-J: Capecitabine: the new generation of flouropyrimidines in colorectal cancer. Expert Rev Anticancer Ther, 4(6):947-955, 2004. 69. Kimura T, Holland WS, Kawaguchi T, Williamson SK, Chansky K, Crowley JJ, Doroshow JH, Lenz H-J, Dandara DR, Gumerlock PH. Mutant DNA in plasma of lung cancer patients: Potential for monitoring response to therapy. Ann. N.Y. Acad. Sci, 1022:55-60, 2004. 70. Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Yu MC, Iqbal S, Lenz HJ, Ladner RD. A 6 bp Polymorphism in the Thymidylate Synthase Gene Causes Message Instability and is Associated with Decreased Intratumoral TS mRNA Levels. Pharmacogenetics, 14(5):319-327, 2004. [PMID: 15115918] 71. Lara PN, Law LY, Wright JJ, Frankel P, Twardowski P, Lenz HJ, Lau DH, Kawaguchi T, Gumerlock PH, Doroshow JH, Gandara DR. Intermittent dosing of the farnesyl transferase inhibitor (R115777) in advanced mailgnant solid tumors: a phase I California Cancer Consortium Trial. Anti-Cancer Drugs, 16(3):317-21, March 2005. 72. Garcia AA, Blessing JA, Lenz HJ, Darcy KM, Mannel RS, Miller DS, Husseinzadeh N. Gynecologic Oncology Group. Phase II clinical trial of capecitabine of ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study. Gynecologic Oncology, 96(3):810-7, March 2005. 73. Zhang W, Park DJ, Lu B, Yang DY, Gordon M, Groshen S, Yun J, Press OA, Vallboehmer D, Rhodes K, Lenz HJ. Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation. Clinical Cancer Research, 11(2 pt 1): 600-5, Jan 15, 2005. 74. Vallboehmer D, Lenz HJ. EGFR as a Target for Chemotherapy. Clin Colorectal Cancer 5(1): S19-S27, 2005. 75. Vallboehmer, D, Zhang W. Gordon M, Yang DY, Yun J, Press OA, Rhodes KE, Sherrod AE, Iqbal S, Danenberg K, Groshen S, Lenz HJ. Molecular Determinants of Cetuxiamb Efficacy of Cetuxmab therapy. J Clin Oncology, 23(15): 3536-3544, 2005. 76. Garcia AA, Pujari M, Jeffers S, Iqbal S, Lenz HJ, Beringer P, Louie S. Phase I clinical and pharmacokinetic trial of and irinotecan administered on a weekly schedule. Cancer Chemotherapy and Pharmacology, 56(1):75-82, July 2005. 77. Zhang W, Stoehlmacher J, Park DJ, Yang D, Borchard E, Gil J. Tsao-Wei DD, Yun J, Gordon M, Press OA, Rhodes K, Groshen S, Lenz HJ. Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer. Clinical Colorectal Cancer, 5(2):124-31, July 2005. 78. Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS. Assessment of infusional 5-Fluorouracil schedule and dose intensity: a southwest oncology group and eastern cooperative oncology group study.Clinical Colorectal Cancer, 5(2):119-23, July 2005. 79. Clark JW, Eder JP, Ryan D, Lathia C, Lenz HJ. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clinical Cancer Research, 11(15):5472-5480, Aug 1, 2005. 80. Venook AP. Blanke CD. Niedzwiecki D. Lenz HJ. Taylor JR. Hollis DR. Sutherland S. Goldberg RM. Cancer and Leukemia Group B/Southwest Oncology Group trial Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 59 of 173

80405: a phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma. Clinical Colorectal Cancer, 5(4):292-4, 2005 Nov. 81. Ajani J, Lee FC, Singh D, Haller DG, Lenz H-J, Benson AB, Yanagihara R, Phan AT, Yao JC, Strumberg D. A Multicenter Phase II Trial of S-1 Plus Cisplatin in Patients with Untreated Advanced Gastric or Gastroesophageal Junction Adenocarcinoma. J Clin Oncol, 21(24)4:1-5, 2006. 82. Kemeney NE, Niedzwiecki D, Hollis DR, Lenz H-J, Warren RS, Naughton MJ, Weeks JC, Sigurdson ER, Herndon JE, Zhang C, Mayer RJ, Zhang W, Park DJ. Hepatic Arterial Infusion Versus Systemic Therapy for Hepatic Metastatses from Colorectal Cancer: A Randomized Trail of Efficacy, Quality of Life, and Molecular Markers (CALGB 9481). J Clin Oncol, 24(9)1395-1403, March 2006. 83. McCoy S, Macdonald J, Rivkin S, Dakhil S, Lenz H-J, Abbruzzese J, Tanaka M, Whitehead R. Phase II trial of R115777 in patients with advanced colorectal cancer: A Southwest Oncology Group study. Invest New Drugs, 23(5):485-487, Oct. 2005, [PMID: 16133800] 84. Garcia AA, Iqbal S, Quinn D, Edwards E, Lenz H-J, Weber J. Phase I Clinical Trial of Weekly Docetaxel and Exisulind, A Novel Inducer of Apoptosis. Invest New Drugs, 24(1):79-83, 2006. [PMID: 16379039]. 85. Lara P, Gandara D, Stadler W, Quinn D, Vanloan M, Gumerlock P, Vokes E, Lenz H- J, Doroshow J, Longmate J, Vogelza N, Wexler J. A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone Refractory Prostate Cancer Patients with Bone Metastases. Clin Cancer Res, 12(5):1556-1563, March 1, 2006. 86. El-Khoueiry A, Lenz H-J. Pharmacogenomics and Molecular Biology in Gastrointestinal Cancers. Atlas in GI Cancers, 2006. 87. Gordon MA, Gil J, Lu B, Zhang W, Yang D, Yun J, Schneider S, Groshen S, Iqbal S, Press OA, Rhodes K, Lenz H-J. Genomic profiling associated with receurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics, 7:67-88, Jan 2006. 88. Ajani J, Safran H, Bokemeyer C, Shah M, Lenz H-J, Van Cutsem E, Burris H, Lebwohl D, Mullaney B. A multi-center phase II study of BMS-247550 () by two schedules in patients with metastatic gastric adenocarcinoma previsouly treated with a . Invest New Drugs, 5:441-6. Mar 2006. 89. Whitehead R, McCoy S, Macdonald J, Rivkin S, Neubauer MA, Dakhil S, Lenz H-J, Abbruzzese J, Tanaka M. Phase II trial of R115777 in patients with advanced colorectal cancer: A Southwest Oncology Group study. Invest New Drugs, 24(4):335-41, July 2006. 90. Lenz H-J. Anti-EGFR Mechanism of Action: Antitumor Effect and Underlying Cause of Adverse Events. Oncology, (20) 5:5-14, April 2006. 91. Vallbohmer D, Lenz H-J. Predictive and prognostic factors in the neoadjuvant/adjuvant therapy of gastrointestinal tumors: wishful thinking or reality? [German] Zentralblatt fur Chururgie, 131:148-156, May 2006. 92. Zhang W, Gordon M, Press OA, Rhodes K, Vallbohmer D, Yang DY, Park D, Fazzone W, Schultheis A, Sherrod AE, Iqbal S, Groshen S, Lenz HJ. Cyclin D1 and Epidermal Growth Factor Polymorphisms Associated with Survival in Patients with Advanced Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 60 of 173

Colorectal Cancer Treated with Cetuximab. Pharmacogenet Genomics, 16(7):475-483, July 2006, [PMID: 16788380]. 93. Schneider S, Park D, Yang D, El-Khoueiry A, Sherrod A, Groshen S, Streeter O, Iqbal S, Danenberg K, Lenz HJ. Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation. Pharmacogenetics & Genomics, 16(8):555-563, Aug 2006. 94. Azuma M, Danenberg K, Iqbal S, El-Khoueiry A, Zhang W, Yang D, Koizumi W, Saigenji K, Danenberg P, Lenz H-J. Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer. Clin Colorectal Cancer 6(3):214-218; Sep 2006. 95. El-Khoueiry AB, Lenz H-J. Second line strategies on the treatment of advanced colorectal cancer. Curr Clin Onc: Colorectal Cancer, 119-130. October 2006. 96. Lenz H-J, Van Cutsem E, Khambata-Ford S, Mayer R, Gold P, Stella P, Mirtsching B, Cohn A, Pippas A, Azarnia N, Tsuchihasi, Mauro D, Rowinsky E. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin and flouropyrimidines. J Clin Onc, 24(30):4914-1921, October 2006. 97. Vallboehmer D, Iqbal S, Yang DY, Rhodes K, Zhang W, Gordon M, Fazzone W, Schultheis A, Sherrod A, Danenberg K, Lenz H-J. Molecular Determinants of Irinotecan Efficacy. International Journal of Cancer, 119(10):2435-42. Nov 15, 2006. 98. Yang D, Schneider S, Mizutomo A, Iqbal S, El-Khoueiry A, Groshen S, Agafitei D, Danenberg K, Danenberg P, Ladner R, Lenz H-J. Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. Clin Col Cancer, 6(4): 305-11, Nov 2006. 99. Lara PN, Longmate J, Koczywas M, Lenz HJ, Quinn DI, Davies AM, Lau DHM, Gumerlock PH, Doroshow JH, Schenkein D, Kashala O, Gandara DR. Phase I Study of plus Docetaxel in Advanced Non-Small-Cell Lung Cancer and Other Solid Tumors. J Thorac Oncol, 1:126-134, 2006. 100. Park DJ, Lenz HJ. Determinants of chemosensitivity in gastric cancer. Curr Op Pharmacol, 4: 337-344, 2006. 101. Vallbohmer D, Iqbal S, Yang DY, Rhodes KE, Zhang W, Gordon M, Fazzone W, Schultheis AM, Sherrod AE, Danenberg KD, Lenz HJ. Molecular determinants of irinotecan efficacy. Int J Cancer, 10: 2435-42, 2006. 102. Goldberg RM, Rothenberg ML, Van Cutsem E, Benson AB, Blanke CD, Diasio RB, Grothey A, Lenz H-J, Meropol NJ, Ramanathan RK, Becerra C, Wickham R, Armostrong D, Viele C. The Continuum of Care: A Paradigm for the Management of Metastatic Colorectal Cancer. The Oncologist, 1:38-50, 2007. 103. Synold T, Takimoto C, Doroshow J, Gandara D, Mani S, Remick S, Mulkerin D, Hamilton A, Sharma S, Ramanathan R, Lenz H-J, Graham M, Longmate J, Kaufman B, Ivy P. Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired hepatic function: A National Cancer Institute organ dysfunction working group study. Clin Cancer Res, 15;13(12):3660-6, Jun 2007. 104. Chen H, Xia M, Lin M, Yang H, Kulhenkamp J, Li T, Sodir N, Chen Y, Lenz HJ, Laird P, Clarke S, Mato J, Lu S. Role of methionine adenosyltranferase 2A and s- Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 61 of 173

Adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology, 133(1):207-218, July 2007. 105. Garcia AA, Blessing JA, Darcy KM, Lenz HJ, Zhang W, Hannigan E, Moore DH. Phase II clinical trial of capecitabine in the treatment of advanced, persistent or recurrent squamous cell carcinoma of the cervix with translational research: A gynecologic oncology group study. Gynecol Oncol, 3: 572-9, 2007. 106. Shibata S, Chow W, Frankel P, Juhasz A, Leong L, Lim D, Margolin K, Morgan R, Newman E, Somlo G, Yen Y, Synold T, Gandara D, Lenz HJ, Doroshow J. A phase I study of oxaliplatin in combination with gemcitabine: correlation of clinical outcome with gene expression. J Clin Oncol, 30: 4914-21, 2007. 107. Lenz HJ, Lee FC, Haller DG, Singh D, Benson AB, Strumberg D, Yanagihara R, Yao JC, Phan AT, Ajani JA. Extended safety and efficacy data on S-1 plus cisplatin in patients with untreated, advanced gastric carcinoma in a multicenter phase II study. Cancer, Jan 1;(109): 33-40, 2007. 108. Lenz H-J. Mangement and preparedness for infusion and hypersensitivity reactions. Oncologist, 12(5): 601-9 May 2007. 109. O’Dwyer P, Eckhardt SG, Haller D, Tepper J, Ahnen D, Hamilton S, Benson AB, Rothenberg M, Petrelli N, Lenz HJ, Diasio R, DuBois R, Sargent D, Sloan J, Johnson CD, Comis R, O’Connell M. Priorities in Colorectal Cancer Research: Recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. J Clin Oncol, 1;25(16):2313-2321, June 2007. 110. Zhang W, Gordon M, Schultheis AM, Nagashima F, Azuma M, Chang HM, Borucka E, Yang DY, Sherrod AE, Lurje G, Iqbal S, Groshen S, Lenz H-J. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of EGFR-expressing metastatic colorectal cancer patients treated with single-agent Cetuximab. J Clin Onc, 25(24) 3712-3718, Aug 2007. 111. Zhang W, Press OA, Haiman C, Yang D, Gordon MA, Fazzone W, El-Khoueiry A, Iqbal S, Sherrod A, Lurje G, Lenz H-J. Association of Methylenetetrahydrofolate Reductase Gene Polymorphisms and gender-specific survival in Patients with Metastatic Colon Cancer. J Clin Onc, 25(24):2726-31, Aug 2007. 112. Press M, Lenz H-J. EGFR, HER2 and VEGF Pathways validated targets for cancer treatment. Drugs, 67(14); 2045-2075, 2007. 113. Saltz LB, Lenz HJ, Kindler HL, Hochster HS, Wadler S, Hoff PM, Kemeny NE, Hollywood EM, Gonen M, Quinones M, Morse M, Chen HX. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The Bond-2 Study. J Clin Onc, 25(29), 4557-4561, Oct 2007. 114. Strumberg D, Clark JW, Awada A, Moore MJ, Richly H, Hendlisz A, Hirte HW, Eder JP, Lenz HJ, Schwartz B. Safety, pharmacokinetics, and preliminary antitumor activity of sarafenib a review of four phase I trials in patients with advanced refractory solid tumors. Onc, 12(4): 426-437, April 2007. 115. Azuma M, Shi M, Danenberg K, Gardner H, Barrett C, Jacques C, Sherod A, Iqbal S, El-Khoueiry A, Yang D, Zhang W, Danenberg P, Lenz H-J. Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients. Pharmacogenomics 8(12): 1705-1713, 2007. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 62 of 173

116. Wilson PM, Ladner RD, Lenz H-J. Exploring alternative individualized treatment strategies in colorectal cancer. Clin Colorectal Ca, 7(1): S28-S36, 2007. 117. Venook AP, Blanke CD, Niedzwiecki D, Lenz H-J, Taylor JR, Hollis DR, Sutherland S, Goldberg RM. Revisiting the cancer leukemia group B/Southwest Oncology Group 80405 trial: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma. Clin Colorectal Ca 6(7): 536-8, May 2007. 118. Beumer JH, Parise RA, Newman EM, Doroshow JH, Synold TW, Lenz H-J, Egorin M. Concentrations of the DNA methyltransferase inibitor 5-fluoro-2’-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemotherapy and Pharmacology, 62(2): 363-368, July 2007. 119. Saltz LB, Rosen LS, Marshall JL, Belt RJ, Hurwitz HI, Eckhardt SG, Bergsland EK, Haller DG, Lockhart AC, Rocha Lima CM, Huang X, DePrimo SE, Chow-Maneval E, E. Chao RC, Lenz HJ. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Onc, 25(30): 4793-9, Oct 2007. 120. Lurje G, Zhang W, Lenz H-J. Molecuar prognostic markers in locally advanced colon cancer. Clin Col Cancer, 6(10): 683-90, Nov 2007. 121. Garcia A, Hirte H, Fleming G, Yang D, Tsao-Wei D, Roman L, Groshen S, Swenson S, Markland F, Gandara D, Scudder S, Morgan R, Chen H, Lenz H-J, Oza A. Phase II clinical trial of bevacizumab and low-dose metronomic oral in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia. J Clin Onc, 26(1):76-82, 2008. 122. Wilson PM, Ladner RD, Lenz H-J. Predictive and prognostic markers in colorectal cancer. GastroIntestinal Ca Res, 1(6):237-246, 2008. 123. Gibbons J, Egorin M, Ramanathan R, Fu P, Mulkerin D, Shibabta S, Takimoto C, Mani S, LoRusso P, Grem J, Pavlick A, Lenz H-J, Flick S, Reynolds S, Lagattuta T, Parise R, Wang Y, Murgo A, Ivy P, Remick S. Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: A study by the National Cancer Institute organ dysfunction working group. J Clin Onc, 26(4):570-576, 2008. 124. Davies AM, Ruel C, Lara PN, Lau DH, Gumerlock PH, Bold R, Shibata S, Lenz HJ, Schenkein DP, Gandara DR. The bortezomib in combination with gemcitabine and carboplatin in advanced non-small cell lung cancer: a California Cancer Consortium Phase I study. J Thoracic Onc, 3(1):68-74, Jan 2008. 125. Lurje G, Zhang W, Yang D, Groshen S, Hendifar A, Husain H, Nagashima F, Chang FM, Fazzone W, Ladner R, Pohl A, Ning Y, Iqbal S, El-Khoueiry A, Lenz H-J. Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. Pharmacogenetics & Genomics, 18(2):161-8, Feb 2008. 126. Pohl A, Lurje M, Kahn M, Lenz H-J. Stem Cells in Colon Cancer. Comprehensive Review. Clinical Colorectal Cancer, 7(2):92-98, March 2008. 127. Press OA, Zhang W, Gordon M, Yang D, Lurje G, Iqbal S, El-Khoueiry A, Lenz H-J. Gender-related survival differences Associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res, 68(8): 3037-42, April 2008. 128. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz H-J, Danenberg K, Danenberg P. Messenger RNA expression of vascular Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 63 of 173

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measure of quality of care. Clin Colorectal Cancer, 12(4):275-9, Dec 2013, [PM ID: 24188686]. 247. Lee YS, Choi D, Kim NY, Yang S, Jung E, Hong M, Yang D, Lenz HJ, Hong YK. CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. Int J Cancer, 135(1):232-7, doi: 10.1002/ijc.28668. Dec 2013, [PM ID 24338666]. 248. Lenz HJ. Testing for RAS Mutations in Patients with Metastatic Colorectal Cancer. Colorectal Cancer in Focus. Clinical Advances in Hematology & Oncology. 12(1):48- 49, Jan 2014, [PM ID: 25000315]. 249. Ning Y, Gerger A, Zhang W, Hanna DL, Yang D, Winder T, Wakatsuki T, Labonte MJ, Sintzing S, Volz N, Sunakawa Y, Stremitzer S, El-Khoueiry R, Lenz HJ. Plastin Polymorphisms Predict Genter-and Stage-Specific Colon Cancer Recurrence after Adjuvant Chemotherapy. Mol Cancer Ther, 13(2):1-12, Jan 2014, [PM ID: 24170770]. 250. El-Khoueiry AB, Rankin C, Siegel AB, Iqbal S, Gong IY, Micetich KC, Kayaleh OR, Lenz HJ, Blanke CD. S0941: a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder carcinoma or cholangiocarcinoma. Br J Cancer, Jan 2014, 110(4):882-7, [PM ID 24423918]. 251. Maus MK, Grimminger PP, Mack PC, Astrow SH, Stephens C, Zeger G, Hsiang J, Brabender J, Friedrich M, Alakus H, Holscher AH, Lara P, Danenberg KD, Lenz HJ, Gandara DR. KRAS mutations in non-small-cell lung cancer and colorectal cancer: Implications for EGFR-targeted therapies. Lung Cancer, 83(2): 163-7, Feb 2014, [PM ID: 24331409]. 252. Robinson DA, Hochster HS, Ryan DP, Wolpin BM, McCleary NJ, Abrams TA, Chan JA, Iqbal S, Lenz HJ, Lim D, Rose J, Bekaii-Saab, T, Chen HX Fuchs CS, Ng K. Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: results of a phase I study of pertuzumab plus cetuximab in cetuximab-refactory patients. Investigational New Drugs, 32(1):113-22, doi: 10.1007/s10637-013-9956-5, Feb 2014, [PM ID: 23568716]. 253. Loupakis F, Antoniotti C, Cremolini C, Zhang W, Yang D, Wakatsuki T, Bohanes P, Schirripa M, Salvatore L, Masi G, Ricci V, Graziano F, Ruzzo A, Benhaim L, Marmorino F, Ning Y, El-Khoueiry R, Falcone A, Lenz HJ. Prospective study of EGFR intron 1 (CA) repeats variants as predictors of benefit from cetuximab and irinotecan in chemo-refractory metastatic colorectal cancer (mCRC) patients. Pharmacogenomics J, 14(4):322-7, doi: 10.1038/tpj.2014.1. Feb 2014, [PM ID: 24513691]. 254. Sebio A, Stintzing S, Stremitzer S, Zhang W, Lenz HJ. Panitumumab : leading to better overall survival in metastatic colorectal cancer? Expert Opin Biol Ther, 14(4):535-48, doi: 10.1517/14712598.2014.894502, Apr 2014, [PM ID: 24593265]. 255. Bendell JC, Lenz HJ, Ryan T, El-Rayes BF, Marshall JL, Modiano MR, Hart LL, Kingsley CD, George TJ, Nakashima D, Berlin JD. Phase ½ study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer. Invest New Drugs, 32(4):682-90.doi: 10.1007/s10637-014-0088-3, Aug 2014, [PM ID: 24691674]. 256. Sebio A, Kahn M, Lenz HJ. The potential of targeting Wnt/B-catenin in colon cancer. Expert Opin Ther Targets,18(6):611-5, June 2014, [PM ID: 24702624]. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 75 of 173

257. Wilson PM, Danenberg PV, Johnston PG, Lenz HJ, Ladner RD. Standing the test of time: targeting thymidylate biosynthesis in cancer therapy. Nat Rev Clin Oncol, 11(5):282-98, May 2014, [PM ID: 24732946]. 258. Stintzing S, Lenz HJ. Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach. Clin Cancer Res, Apr 2014, 20:3064-3070, [PM ID: 24756373]. 259. Stremitzer S, Sebio A, Stintzing S, Lenz HJ. Panitumumab safety for trating colorectal cancer. Expert Opin Drug Saf, 13(6):843-51. doi: 10.1517/14740338.2014.915024, June 2014, [PM ID: 24766434]. 260. Lin EH, Lenz HJ, Saleh MN, Mackenzie MJ, Knost JA, Pathiraja K, Langdon RB, Yao SL, Lu BD. A randomized, phase II study of the anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody robatumumab (SCH 717454) in patients with advanced colorectal cancer. Cancer Med, 3(4):988-97., Aug 2014, [PM ID: 24905030]. 261. Xu Y, Zhang H, Lit LC, Grothey A, Athanasiadou M, Kiritsi M, Lombardo Y, Frampton AE, Green AR, Ellis IO, Ali S, Lenz HJ, Thanou M, Stebbing J, Giamas G. The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin B1. Sci Signal, 17:7(330):ra58, June 2014, [PM ID: 24939894]. 262. Van Schaeybroeck S,Kalimutho M, Dunne PD, Carson R, Allen W, Jithesh PV, Redmond KL, Sasazuki T, Shirasawa S, Blayney J, Michieli P, Fenning C, Lenz HJ, Lawler M, Longley DB, Johnston PG. ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance To MEK Inhibitors in KRAS Mutant Colorectal Cancer. Cell Rep, 7(6):1940-55, June 2014, [PM ID: 24931611]. 263. Lenz HJ, Kahn M. Safely Targeting Cancer Stem Cells Via Selective Catenin Coactivator Antagonism. Cancer Sci, 105(9):1087-92, Sept 2014, [PM ID: 24975284] 264. Stebbing J, Zhang H, Xu Y, Lit LC, Green AR, Grothey A, Lombardo Y, Periyasamy M, Blighe K, Zhang W, Shaw JA, Ellis IO, Lenz HJ, Giamas G. KSR1 Regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34(16):2103-14, June 2014, [PM ID: 24909178]. 265. Geva R, Vecchione L, Kalogeras KT, Vittrup Jensen B, Lenz HJ, Yoshino T, Paez D, Montagut C, Souglakos J, Cappuzzo F, Cervantes A, Frattini M, Fountzilas G, Johansen JS, Hogdall EV, Zhang W, Yang D, Yamazaki K, Nishina T, Papamichael D, vincenzi B, Macarulla T, Loupakis F, De Schutter J, Spindler KL, Pfeiffer P, Ciardiello F, Piessevauz H, Tejpar S. FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study. Gut, 64(6):921-8, July 2014, [PM ID: 25011934]. 266. Ulrich CM, Rankin C, Toriola AT, Makar KW, Altug-Teber O, Benedetti JK, Holmes RS, Smalley SR, Blanke CD, Lenz HJ. Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT- 0144; SWOG 9304). Cancer, 120(21):3329-37, July 2014, [PM ID: 25041994]. 267. Yang D, Hanna DL, Usher J, LoCoco J, Chaudhari P, Lenz HJ, Setiawan VW, El- Khoueiry A. Impact of sex on the survival of patients with hepatocellular carcinoma: A Surveillance, Epidemiology, and End Results analysis. Cancer, 120(23):3707-16, July 2014, [PM ID: 25081299]. 268. Volz NB, Stintzing S, Zhang W, Yang D, Ning Y, Wakatsuki T, El-Khoueiry RE, Li JE, Kardosh A, Loupakis F, Cremolini C, Falcone A, Scherer SJ, Lenz HJ. Genes involved in pericyte-driven tumor maturation predict treatment benefit of first-line Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 76 of 173

FOLFIRI plus bevacizumab in patients with metastatic colorectal cancer. Pharmacogenomics J, 15(1):69-76. doi: 10.1038/tpj.2014.40, July 2014, [PM ID: 25069475]. 269. Semrad T, Barzi A, Lenz HJ, Hutchins IM, Kim Ej, Gong IY, Tanaka M, Bechett L, Holland W, Burich RA, Snyder-Solis L, Mack P, Lara PN Jr. Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results. Int J Clin Oncol, 20(3):518-24, Aug 2014, [PM ID: 25091263; PMC4318776]. 270. Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J, De Roock W, Salzman DW, Zhang W, Yang D, Pilati C, Bouche O, Piessevaux H, Tejpar S. A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic colorectal Cancer reated with Salvage Cetuximab/Panitumumab Monotherapy. Clin Cancer Res, 20(17):4499-510, Sept 2014, [PM ID: 25183481]. 271. Wakatsuki T, Stintzing S, Zhang W, Yang D, Azuma N, Ning Y, Yamauchi S, Matsusaka S, Volz NB, Sunakawa Y, Koizumi W, Watanabe M, Barzi A, El-Khoueiry AB, Shah MA, Lenz HJ. Single nucleotide polymorphisms in AREG and EREG are porgnostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent. Pharmacogenet Genomics, 24(11):539-47, Nov 2014, [PM ID: 25203737; PMC ID: 4190124]. 272. Sunakawa Y, Wakatsuki T, Yang D, Zhang W, NingY, Stintzing S, Stremitzer S, Yamauchi S, Sebio A, El-Khoueiry R, Iqbal S, Barzi A, Gerger A, Stotz M, Azuma M, Watanabe M, Koizumi W, Lenz HJ. Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients. Pharmacogenet Genomics, 24(12):588-96, Dec 2014, [PM ID: 25203738; PMC ID: 4218879]. 273. Lenz HJ, Stintzing S.So much effort, so little progress. J Natl Cancer Inst, 106(10), Sept 2014, [PM ID: 25246612]. 274. Philip PA, Goldman B, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Wakatsuki T, Iqbal S, Gaur R, Benedetti JK, Blake CD. Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer,120(19):2980- 5, Oct 2014, [PM ID: 25041791]. 275. Benhaim L, Zhang W, Wakatsuki T, Yang D, Gerger A, Bohanes P, Paes D, Loupakis F, LaBonte MJ, Ning Y, El-Khoueiry R, Ladner R, Wilson P, Zhang H, Giamas G, Stebbing J, Lenz HJ. Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer. Clin Cancer Res, 15(3):235-40, Oct 2014, [PM ID: 25287073]. 276. Hobday TJ, Reidy-Lagunes D, Moore MJ, Strosberg J, Kaubisch A, Shah M, Kindler HL, Lenz HJ, Chen H, Erichman C. Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors. J Clin Oncol, 33(14):1551-6, Dec 2014, [PM ID: 25488966; PMC4417726]. 277. Bohanes P, Yang D, Loupakis F, LaBonte MJ, Gerger A, Ning Y, Lenz C, Lenz F, Wakatsuki T, Zhang W, Benhaim L, El-Khoueiry A, El-Khoueiry R, Lenz HJ. Integrin genetic variants and stage-specific tumor recurrence in patients with stage II and II colon cancer. Pharmacogenomics J, 15(3)226-34, Dec 2014, [PM ID: 25487679]. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 77 of 173

278. Koczywas M, Frankel PH, Synold TW, Lenz HJ, Mortimer JE, El-Khoueiry AB, Gandara DR, Cristea MC, Chung VM, Lim D, Reckamp KL, Lau DH, Doyle LA, Ruel, C, Carroll MI, Newman EM. Phase I study of the halichondrin B analogue mesylate in combination with cisplatin in advanced solid tumors. Br J Cancer, 111(12):2268-74, Dec 2014, [PM ID: 25349975; PMC4264453]. 279. Maus MK, Hanna DL, Stephens CL, Astrow SH, Yang D, Grimminger PP, Loupakis F, Hsiang JH, Zeger G, Wakatsuki T, Barzi A, Lenz HJ. Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy. Pharmacogenomics J, 15(4):354-62, Dec 2014, [PM ID: 25532759; PMC4478287] 280. Sebio A, Gerger A, Matsusaka S, Yang D, Zhang W, Stremitzer S, Stintzing S, Sunakawa Y, Yamauchi S, Ning Y, Fujimoto Y, Ueno M, Lenz HJ. Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer. Pharmacogenet Genomics, 25(1):30-7, Jan 2015, [PM ID: 25379721; PMC4260998]. 281. Hochster HC, Uboha N, Messersmith W, Gold PJ, ONeil BH, cohen D, Denlinger C, Cohen S, Leichman CG, Leichman L, Lenz HJ. Erratum to: Phase II study of selumetinib (AZD6244, ARRY-142866) plus irinotecan as second-line therapy in pateints with K-RAS mutated colorectal cancer. Cancer Chemother Pharmacol, 75(1):17-23, doi: 10.1007/s00280-014-2625-3, Jan 2015, [PM ID: 25322874]. 282. Newman EM, Morgan RJ, Kummar S, Beumer JH, Blachard MS, Ruel C, El-Khoueiry AB, Carroll MI, Hou JM, Li C, Lenz HJ, Eisman JL, Doroshow JH. A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine. Cancer Chemother Pharmacol, 75(3):537-46, Jan 2015, [PM ID: 25567350; PMC4344391]. 283. Bohanes P, Rankin C, Blanke CD, Winder T, Ulrich CM, Smalley SR, Rich TA, Martenson JA, Benson AB 3rd, Mayer RJ, Cripps CM, Danenberg KD, Makar KW, Zhang W, Benedetti JK, Lenz HJ. Pharmacogenetic analysis of INT 0144 trial: association of polymorphisms with survival and toxicity in rectal cancer patients treated with 5-FU and radiation. Clin Cancer Res, 21(7):1583-90, Jan 2015, [PM ID: 25589620; PMC4566931]. 284. Van Cutsem E, Lenz HJ, Kohne CH, Heinemann V, Teipar S, Melezinek I, Beier F, Stroh C, Rougier P, Van Krieken JH, Ciardiello F. Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer. J Clin Oncol, 33(7):692-700, Jan 2015, [PM ID: 25605843]. 285. Stintzing S, Stremitzer S, Sebio A, Lenz HJ. Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): personalized medicine at work. Hematol Oncol Clin North Am, 29(1):43-60, Feb 2015, [PM ID: 25475572]. 286. Sunakawa Y, Stremitzer S, Cao S, Zhang W, Yang D, Wakatsuki T, Ning Y, Yamauchi S, Stintzing S, Sebio A, El-Khoueiry R, Matsusaka S, Parekh A, Barzi A, Azuma M, Watanabe M, Koizumi W, Lenz HJ. Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer. Ann Oncol, 26(2):332-9, Feb 2015, [PM ID: 25411415; PMC4304380]. 287. Stremitzer S, Zhang W, Yang D, Ning Y, Stintzing S, Sebio A, Sunakawa Y, Yamauchi S, Matsusaka S, El-Khoueiry R, Stift J, Wrba F, Gruenberger T, Lenz HJ. Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 78 of 173

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line Chemotherapy in Metastatic Colorectal Cancer. Clin Cancer Res. (09/2018). [PMID: 30224341] 404. Sunakawa Y, Mogushi K, Lenz HJ, Zhang W, Tsuji A, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Tanioka H, Negoro Y, Moran M, Astrow SH, Hsiang J, Stephens C, Fujii M, Ichikawa W. Tumor Sidedness and Enriched Gene Groups for Efficacy of First-line Cetuximab Treatment in Metastatic Colorectal Cancer. Mol Cancer Ther. 17(12):2788-2795 (12/2018). [PMID: 30275242] 405. Tokunaga R, Cao S, Naseem M, Lo JH, Battaglin F, Puccini A, Berger MD, Soni S, Millstein J, Zhang W, Stintzing S, Loupakis F, Cremolini C, Heinemann V, Falcone A, Lenz HJ. Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy. Clin Colorectal Cancer. 2019 Mar;18(1):e8-e19. doi: 10.1016/j.clcc.2018.09.003. Epub 2018 Sep 13. [PMID: 30293873] 406. Puccini A, Battaglin F, Lenz HJ. Management of Advanced Small Bowel Cancer. Curr Treat Options Oncol. 19(12): 69, (11/2018). Review. [PMID: 30397729] 407. Suenaga M, Cao S, Zhang W, Yang D, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Soni S, Barzi A, Yamaguchi T, Lenz HJ. Genetic variants in CCL5 and CCR5 genes and serum VEGF-A levels predict efficacy of bevacizumab in metastatic colorectal cancer patients. Int J Cancer. (11/2018). [PMID: 30411783] 408. Cheng Q, Shi X, Han M, Smbatyan G, Lenz HJ, Zhang Y. Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity. J Am Chem Soc. (11/2018). [PMID: 30452238] 409. Loupakis F, Hurwitz HI, Saltz L, Arnold D, Grothey A, Nguyen QL, Osborne S, Talbot J, Srock S, Lenz HJ. Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer. Br J Cancer. 119(12): 1451-1455. (11/2018). [PMID: 30487637] 410. Battaglin F, Naseem M, Lenz HJ, Salem ME. Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives. Clin Adv Hematol Oncol. 16(11): 735-745 (11/2018). [PMID: 30543589] 411. Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H. Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. J Clin Invest. (11/2018). 128(11): 4912-4923. [PMID: 30130255]. 412. Tokunaga R, Naseem M, Lo JH, Battaglin F, Soni S, Puccini A, Berger MD, Zhang W, Baba H, Lenz HJ. B cell and B cell-related pathways for novel cancer treatments. Cancer Treat Rev. 73: 10-19 (12/2018). Review. [PMID: 30551036] 413. Hurwitz HI, Tan BR, Reeves JA, Xiong H, Somer B, Lenz HJ, Hochster HS, Scappaticci F, Palma JF, Price R, Lee JJ, Nicholas A, Sommer N, Bendell J. Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM). Oncologist. (12/2018). [PMID: 30552157] Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 92 of 173

414. Cheng Q, Shi X, Han M, Smbatyan G, Lenz HJ, Zhang Y. Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity. J Am Chem Soc.(12/2018). 140(48):16413-16417. [PMID: 30452238] 415. Suenaga M, Stintzing S, Cao S, Zhang W, Yang D, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Soni S, Barzi A, Heinemann V, Lenz HJ. Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial. Eur J Cancer. (01/2019). 107:100-114. [PMID: 30554073] 416. Battaglin F, Lenz HJ. What Should We Do Better? Lessons from Negative Results of a Biomarker Validation Study. J Natl Cancer Inst. (01/2019). doi: 10.1093/jnci/djy217. [Epub ahead of print]. [PMID: 30649462] 417. Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeböller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnström H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldés T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collée JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dörk T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, García-Sáenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guénel P, Håkansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Høgdall E, Hong YC, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kühl T, Khaw KT, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz HJ, et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. (01/2019). 25;10(1):431. [PMID: 30683880] 418. Puccini A, Marín-Ramos NI, Bergamo F, Schirripa M, Lonardi S, Lenz HJ, Loupakis F, Battaglin F. Safety and Tolerability of c-MET Inhibitors in Cancer. Drug Saf. (02/2019). 42(2):211-233. [PMID: 30649748] 419. Tokunaga R, Naseem M, Lo JH, Battaglin F, Soni S, Puccini A, Berger MD, Zhang W, Baba H, Lenz HJ. B cell and B cell-related pathways for novel cancer treatments. Cancer Treat Rev. (02/2019). 73:10-19. [PMID: 30551036] 420. Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 93 of 173

Kono S, Kooperberg C, Krogh V, Kuehn T, Küry S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, et al. Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst. (02/2019). 111(2):146-157. doi: 10.1093/jnci/djy099. [PMID: 29917119] 421. Chan BM, Hochster HS, Lenz HJ. The safety and efficacy of trifluridine-tipiracil for metastatic colorectal cancer: A pharmacy perspective. Am J Health Syst Pharm. (02/2019). 76(6):339-348. doi: 10.1093/ajhp/zxy006. [PMID: 31361848] 422. Puccini A, Lenz HJ, Marshall JL, Arguello D, Raghavan D, Korn WM, Weinberg BA, Poorman K, Heeke AL, Philip PA, Shields AF, Goldberg RM, Salem ME. Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors. Oncologist. (03/2019). 24(3):319-326. [PMID: 30018131] 423. Tokunaga R, Cao S, Naseem M, Battaglin F, Lo JH, Arai H, Loupakis F, Stintzing S, Puccini A, Berger MD, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Heinemann V, Falcone A, Millstein J, Lenz HJ. AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3. Int J Cancer. (03/2019). doi: 10.1002/ijc.32261. Epub ahead of print. [PMID: 30856283] 424. Puccini A, Loupakis F, Stintzing S, Cao S, Battaglin F, Togunaka R, Naseem M, Berger MD, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Heinemann V, Falcone A, Millstein J, Lenz HJ. Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3. Eur J Cancer. (04/2019). 111:138-147. [PMID: 30852420] 425. Weekes C, Lockhart AC, Lee JJ, Sturm I, Cleton A, Huang F, Lenz HJ. A phase 1b study evaluating the safety and pharmacokinetics of regorafenib in combination with cetuximab in patients with advanced solid tumors. Int J Cancer. (04/2019). doi: 10.1002/ijc.32317. Epub ahead of print. [PMID: 30958892] 426. Lenz HJ, Ou FS, Venook AP, Hochster HS, Niedzwiecki D, Goldberg RM, Mayer RJ, Bertagnolli MM, Blanke CD, Zemla T, Qu X, Wirapati P, Tejpar S, Innocenti F, Kabbarah O. Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance). J Clin Oncol. (05/2019). JCO1802258. doi: 10.1200/JCO.18.02258. [Epub ahead of print]. [PMID: 31042420] 427. Innocenti F, Ou FS, Qu X, Zemla TJ, Niedzwiecki D, Tam R, Mahajan S, Goldberg RM, Bertagnolli MM, Blanke CD, Sanoff H, Atkins J, Polite B, Venook AP, Lenz HJ, Kabbarah O. Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome. J Clin Oncol. (05/2019). 37(14):1217-1227. [PMID: 30865548] 428. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang- Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 94 of 173

GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago- Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Suenaga M, Cao S, Zhang W, Yang D, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Soni S, Barzi A, Yamaguchi T, Lenz HJ. Genetic variants in CCL5 and CCR5 genes and serum VEGF-A levels predict efficacy of bevacizumab in metastatic colorectal cancer patients. Int J Cancer. (05/2019). 144(10):2567-2577. [PMID: 30411783] 429. Tokunaga R, Xiu J, Johnston C, Goldberg RM, Philip PA, Seeber A, Naseem M, Lo JH, Arai H, Battaglin F, Puccini A, Berger MD, Soni S, Zhang W, Hwang JJ, Shields AF, Marshall JL, Baba H, Korn WM, Lenz HJ. Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer. Clin Cancer Res. (05/2019). 25(10):3096-3103. [PMID: 30692096] 430. Parikh AR, Lee FC, Yau L, Koh H, Knost J, Mitchell EP, Bosanac I, Choong N, Scappaticci F, Mancao C, Lenz HJ. MAVERICC, a Randomized, Biomarker-stratified, Phase II Study of mFOLFOX6-Bevacizumab versus FOLFIRI-Bevacizumab as First- line Chemotherapy in Metastatic Colorectal Cancer. Clin Cancer Res. (05/2019). 25(10):2988-2995. [PMID: 30224341] 431. Tilburt J, Yost KJ, Lenz HJ, Zúñiga ML, O'Byrne T, Branda ME, Leppin AL, Kimball B, Fernandez C, Jatoi A, Barwise A, Kumbamu A, Montori V, Koenig BA, Geller G, Larson S, Roter DL. A Multicenter Comparison of Complementary and Alternative Medicine (CAM) Discussions in Oncology Care: The Role of Time, Patient- Centeredness, and Practice Context. Oncologist. (05/2019). pii: theoncologist.2019- 0093. doi: 10.1634/theoncologist.2019-0093. Epub ahead of print. [PMID: 31101701] 432. Morse MA, Overman MJ, Hartman L, Khoukaz T, Brutcher E, Lenz HJ, Atasoy A, Shangguan T, Zhao H, El-Rayes B. Safety of Nivolumab plus Low-Dose Ipilimumab in Previously Treated Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer. Oncologist. (05/2019). pii: theoncologist.2019-0129. doi: 10.1634/theoncologist.2019-0129. Epub ahead of print. [PMID: 31147488] 433. Warsame R, Kennedy CC, Kumbamu A, Branda M, Fernandez C, Kimball B, Leppin AL, O'Byrne T, Jatoi A, Lenz HJ, Tilburt JC. Conversations About Financial Issues in Routine Oncology Practices: A Multicenter Study. J Oncol Pract. (06/2019). JOP1800618. doi: 10.1200/JOP.18.00618. Epub ahead of print. [PMID: 31162996] 434. Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A. Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study. Lancet Oncol. (06/2019). pii: S1470-2045(19)30272-4. doi: 10.1016/S1470-2045(19)30272-4. Epub ahead of print. [PMID: 31262657] 435. Battaglin F, Puccini A, Ahcene Djaballah S, Lenz HJ. The impact of panitumumab treatment on survival and quality of life in patients with RAS wild-type metastatic colorectal cancer. Cancer Manag Res. (06/2019). 11:5911-5924. doi: Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 95 of 173

10.2147/CMAR.S186042. eCollection 2019. [PMID: 31388315][PMCID: PMC6607986] 436. Hu Z, Ding J, Ma Z, Sun R, Seoane JA, Scott Shaffer J, Suarez CJ, Berghoff AS, Cremolini C, Falcone A, Loupakis F, Birner P, Preusser M, Lenz HJ, Curtis C. Quantitative evidence for early metastatic seeding in colorectal cancer. Nat Genet. (07/2019). 51(7):1113-1122. [PMID: 31209394] 437. El-Deiry WS, Goldberg RM, Lenz HJ, Shields AF, Gibney GT, Tan AR, Brown J, Eisenberg B, Heath EI, Phuphanich S, Kim E, Brenner AJ, Marshall JL. The current state of molecular testing in the treatment of patients with solid tumors, 2019. CA Cancer J Clin. (07/2019). 69(4):305-343. [PMID: 31116423] 438. Hurwitz HI, Tan BR, Reeves JA, Xiong H, Somer B, Lenz HJ, Hochster HS, Scappaticci F, Palma JF, Price R, Lee JJ, Nicholas A, Sommer N, Bendell J. Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM). Oncologist. (07/2019). 24(7):921-932. [PMID: 30552157] 439. Donner DB, Nakakura EK, Venook AP, Lenz HJ, Zhang W, Hwang J, Bergsland EK, Lin MH, Toriguchi K, Antonia RJ, Warren RS. High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. PLoS One. (07/2019). 14(7):e0219469. doi: 10.1371/journal.pone.0219469. eCollection 2019. [PMID: 3129133]. 440. Barzi A, Hershman DL, Till C, Barlow WE, Ramsey S, Lenz HJ, Hochster HS, Unger JM. Osteoporosis in colorectal cancer survivors: analysis of the linkage between SWOG trial enrollees and Medicare claims. Arch Osteoporos. (07/2019). 14(1):83. doi: 10.1007/s11657-019-0629-7. [PMID: 31352608] 441. Davis SL, Cardin DB, Shahda S, Lenz HJ, Dotan E, O'Neil BH, Kapoun AM, Stagg RJ, Berlin J, Messersmith WA, Cohen SJ. A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer. Invest New Drugs. (07/2019). doi: 10.1007/s10637-019-00824-1. Epub ahead of print. [PMID: 31338636] 442. Burgermeister E, Battaglin F, Eladly F, Wu W, Herweck F, Schulte N, Betge J, Härtel N, Kather JN, Weis CA, Gaiser T, Marx A, Weiss C, Hofheinz R, Miller IS, Loupakis F, Lenz HJ, Byrne AT, Ebert MP. Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A. EBioMedicine. (07/2019). 45:139- 154. doi: 10.1016/j.ebiom.2019.07.004. Epub 2019 Jul 9. [PMID: 31300350] 443. Donner DB, Nakakura EK, Venook AP, Lenz HJ, Zhang W, Hwang J, Bergsland EK, Lin MH, Toriguchi K, Antonia RJ, Warren RS. High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. PLoS One. (07/2019). 14(7):e0219469. doi: 10.1371/journal.pone.0219469. eCollection 2019. [PMID: 31291332] 444. Takebe N, Beumer JH, Kummar S, Kiesel BF, Dowlati A, O'Sullivan Coyne G, Piekarz R, Rubinstein L, Fogli LK, Vaishampayan U, Goel S, O'Bryant CL, El-Rayes BF, Chung V, Lenz HJ, Kim R, Belani CP, Tuscano JM, Schelman W, Moore N, Doroshow JH, Chen AP.A Phase I Pharmacokinetic Study of in Patients with Advanced Cancers and Varying Degrees of Liver Dysfunction. Br J Clin Pharmacol. (07/2019). doi: 10.1111/bcp.14054. Epub ahead of print. [PMID: 31271459] Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 96 of 173

445. Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Sato K, Ng K, Van Blarigan E, Mayer RJ, Blanke CD, O'Reilly EM, Fuchs CS, Meyerhardt JA. Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405. J Clin Oncol. (08/2019). JCO1901019. doi: 10.1200/JCO.19.01019. [Epub ahead of print]. [PMID: 31408415] 446. Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A. Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study. Lancet Oncol. (08/2019). 20(8):1070-1082. doi: 10.1016/S1470-2045(19)30272-4. Epub 2019 Jun 28. [PMID: 31262657] 447. Innocenti F, Ou FS, Qu X, Zemla T, Niedzwiecki D, Tam R, Mahajan S, Goldberg RM, Bertagnolli MM, Blanke CD, Sanoff H, Atkins J, Polite B, Venook AP, Lenz HJ, Kabbarah O. Reply to S. Sorscher. J Clin Oncol. (09/2019). 37(25):2291-2293. [PMID: 31268798]

Non Peer Reviewed (Invited papers, reviews and editorials) 1. Lenz H-J, Raghavan D, Doroshow J, Gandara DR: Phase I study of bryostatin-1 in combination with cisplatin in treating patients with metastatic or unresectable solid tumors including non-small-cell lung cancer. Clin Lung Cancer 1:151–152, 1999. 2. Lenz H-J, Beart RW: Molecular staging of cancer-commentary. Cancer Case Presentations: The Tumor Board. Publication by the Commission on Cancer of the American College of Surgeons. 60–72, 2000. 3. Iqbal S, Lenz H-J: Current data with irinotecan and cetuximab in colorectal cancer. Advances in Colon Cancer 5:6–8, 2001. 4. Iqbal S, Lenz H-J: Determinants of prognosis and response to therapy in colorectal cancer. Curr Oncol Rep 3:102–108, 2001. 5. Lenz H-J: Gene markers and prediction of response to oxaliplatin and fluorouracil in current management of gastrointestinal malignancies. Selected Presentations from ASCO, 2002. 6. Stoehlmacher J, Lenz H-J: The predictive value of thymidylate synthase (TS) and excision repair cross-complementing (ERCC) gene in first- and second-line chemotherapy of patients with colorectal cancer. Amer J Oncol Rev 1:29–32, 2002. 7. Iqbal S, Lenz HJ: Targeted therapy and pharmacogenomic programs. Cancer 97(8):2076–2082, 2003. 8. Lenz H-J: Clinical update: proteasome inhibitors in solid tumors. Cancer Treat Rev 29(1):41–48, 2003. 9. Iqbal S, Lenz H-J: Molecular predictors of treatment and outcome in colorectal cancer. Curr Gastroenterol Rep 5(5):399–405, 2003. 10. Doroshow JH, Synold TW, Gandara DR, Mani S, Remick SC, Mulkerin D, Hamilton A, Sharma S, Ramanathan RK, Lenz H-J, Graham M, Longmate J, Takimoto CH, Ivy P: Pharmacology of Oxaliplatin in Solid Tumor Patients with Hepatic Dysfunction: A Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 97 of 173

Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group. Semin Oncol 30(4):14–19, 2003. 11. Lenz H-J: Pharmacogenomics in Colorectal Cancer. Semin Oncol 30(4):47–53, 2003. 12. Doroshow JH, Synold TW, Gandara D, Mani S, Remick S, Mulkerin D, Hamilton A, Sharma S, Ramanathan R, Lenz H-J, Graham M, Longmate J, Takimoto C, Ivy P: Pharmacology of Oxaliplatin in Solid Tumor Patients with Hepatic Dysfunction: A Preliminary Report of the National Cancer Institute Organ Dysfunction Working Group. Semin Oncol 30(4):14–19, 2003. 13. Park DJ, Stoehlmacher J, Lenz H-J: Tailoring chemotherapy in advanced colorectal cancer. Curr Opin Pharmacol 3(4):378–385, 2003. 14. Lenz, H-J: (Editorial) The use and development of germline polymorphisms in clinical oncology. J Clin Oncol 22(13): 2519–2521, 2004. 15. Lenz H-J: (Editorial) Molecular markers in gastrointestinal cancer: targeted therapy and tailored chemotherapy. Onkologie 27(1):12–14, 2004. 16. Lenz H-J: Single-agent Cetuximab active in refractory colon cancer. Oncology News International 13:10, 2004. 17. Lenz H-J: Biomarkers and Pharmacogenomics. Amer J Onc Rev 3(10) 7:44-55, 2004. 18. Park DJ, Lenz H-J. The role of proteasome inhibitors in solid tumors. Annals of Medicine. 36(4):296-303, 2004. 19. Iqbal S, Lenz H-J. Angiogenesis inhibitors in the treatment of colorectal cancer. (Review) Sem Oncol 31(6 Suppl 17):10-16, 2004. 20. Iqbal S, Stoehlmacher J, Lenz HJ. Tailored Chemotherapy for Colorectal Cancer: A New Approach to Therapy. Cancer Invest 22(5):762-773, 2004. [PMID: 15581057; PMC Journal – In Process.] 21. Lenz H-J, Lynch PM. Epidemiology, pharmacogenomics, and hereditary cancer of the colon and rectum. Curr Colorectal Cancer Rep 1(2), Nov 2005. 22. Iqbal S, Lenz H-J. Individualized Chemotherapy Based on Genetic and Genomic Profiling. Curr Colorectal Cancer Rep 1(2): 91-102, Nov 2005. 23. El-Khoueiry A, Lenz H-J. Should continous infusion 5-flourouracil (5-FU) become the standard of care in the USA as it is in Europe? Cancer Investigation 24:1-6, Feb 2006. 24. El-Khoueiry A, Lenz H-J. The role of pharmacogenetics in making treatment decisions in colorectal cancer. Curr Colorectal Cancer Rep 2(3) July 2006. 25. Zhang W, Gordon M, Lenz HJ. Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies. Annals of Medicine 38(8); 545-551, 2006. 26. Lenz HJ. Treatment of colorectal cancer since the introduction of irinotecan. A Supplement to Community Oncology, pg 3-7. May 2007. 27. Lenz HJ. Mangement and Preparedeness for Infusion and Hypersensitivity Reactions. The Oncologist 12:601-609, 2007. 28. Manegold P, Lenz HJ. Molecular Markers. New Treatment Strategies for Metastatic Colorectal Cancer.85-108, 2008. 29. Lenz H-J, Johnston J. Accomplishments in 2007 in Biologic Markers for Gastrointestinal Cancers. Gastrointestinal Cancer Research 2(suppl 1):S51-S56, May/June 2008 30. Lenz HJ. Colon Cancer Stem Cells: A New Target In the War Against Cancer. Gastrointestinal Cancer Research. 203-204, 2(4) July/August 2008 Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 98 of 173

31. Lurje G, Pohl A, Manegold P, Lenz H-J. Individualization of Therapy Based on Clinical and Molecular Parameters. Curr Colorectal Cancer Rep 4:193-200, October 2008. 32. Lenz H-J. First-line combination treatment of colorectal cancer with hepatic metastases: Choosing a targeted agent. Cancer treatment Reviews. 34 Suppl 2:S3-7, 2008. 33. Lenz H-J. Basics of Signal Transduction and Targeting EGFR Pathways. 6th Latin American Workshop in Molecular Targeted Therapy of Cancer. pg 12-13, Buenos Aires, Argentina. Nov 21, 2008. 34. Lurje G, Lenz HJ. EGFR signaling and drug discovery. Oncologist. 77(6):400-10, Feb 2009. 35. Pohl A, Lurje G, Manegold PC, Lenz HJ. Pharmacogenomics and –genetics in colorectal cancer. Advanced Drug Delivery Reviews. 61(5):375-380, May 2009. 36. Kohne C-H, Lenz H-J. Chemotherapy with Targeted Agents for Treatment of Metastatic Colorectal Cancer. The Oncologist, 14(5):478-488, May 2009. 37. LaBonte MJ, Wilson PM, Fazzone W, Groshen S, Lenz H-J, Ladner RD. DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines. BMC Medical Genomics, 30;2:67, Nov 2009. 38. Winder T, Lenz HJ. Molecular predictive and prognostic markers in colon cancer. Cancer Treat Rev. 36:550-556, Apr 2010, [PM ID: 20363564]. 39. Wilson PM, Labonte MJ, Lenz HJ. Molecular markers in the treatment of metastatic colorectal cancer. Cancer J, 16(3);262-72, May 2010 [PM ID: 20526105]. 40. Winder T, Lenz HJ. Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer. Gastroenterology, 138(6):2163-76, Jun 2010 [PM ID: 20420953]. 41. Winder T, Lenz HJ. Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy. Oncologist, 15(8):836-44, July 2010 [PMID: 20656916]. 42. Tejpar S, Bertagnolli M, Bosman F, Lenz HJ, Garraway L, Waldman F, Warren R, Bild A, Collins-Brennan D, Hahn H, Harkin DP, Kennedy R, Ilyas M, Morreau H, Proutski V, Swanton C, Tomlinson I, Delorenzi M, Fiocca R, Van Cutsem E, Roth A. Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating gemonics into biomarker discovery. Oncologist, 15(4):390- 404, 2010 [PM ID: 20350999]. 43. Allen WL, Jithesh PV, Oliver GR, Proutski I, Longley DB, Lenz H-J, Proutski V, Harkin PD, Johnston PG. The Colorectal cancer disease-specific transcriptome facilitates the discovery of more biologically and clinically relevant information. BMC Cancer, 10(1):687, Dec 2010 [PM ID: 21172019]. 44. Lurje G, Lenz HJ. Molecular response prediction in multimodality treatment for adenocarcinoma of the esophagus and esophagogastric juction. Recent Results Cancer Research. 182:179-91, 2010 [PM ID: 20676881]. 45. Stintzing S, Lenz HJ. Targeted therapies: Cetuximab dosing by rash-is the scaling of EVEREST meaningful? Nat Rev Clin Oncol, 14;9(10);554-6. doi:10.1038/nrclinonc, Aug 2012, [PM ID: 22889974]. 46. Lenz H-J: (Editorial) Primary Tumor Sidedness as Prognostic and Predictive Biomarker in Metastatic Colorectal Cancer: Further Validation of a Potentially Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 99 of 173

Practice-Changing Variable. JAMA Oncol, PMID: 27722749 DOI: 10.1001/jamaoncol.2016.3777 Oct 10, 2016.

Abstracts 1. Lenz H-J, Fischer JT, Steinke B, Waller HD: Chronic thrombotic-thrombocytopenic purpura: report of a case and review of the literature. Blut 53:182, 1986. 2. Lenz H-J, Steinke B, Waller HD: Recognition of relapse of patients with malignant lymphoma: efficiency of different methods. Blut 53:226, 1986. 3. Lenz H-J, Roos UM, Steinke B, Waller HD: Central nervous involvement in breast cancer: analysis of possible risk factors. Blut 57:245, 1988. 4. Lenz H-J, Schuler U, Hicking W, Dahmer W, Robinson C, Ehninger G: Phase I study of clebopride IV, a new benzamide derivate. Blut 57:238, 1988. 5. Lenz H-J, Steinke B, Roos UM, Beidritzky M, Waller HD: Central nervous involvement in breast cancer. J Cancer Res Clin Oncol 114:28, 1988. 6. Lenz H-J, Steinke B, Roos UM, Beidritzky M, Waller HD: Cerebrale manifestationen bei patientinnen mit mammakarzinom. Klinische Wochenschrift 66(Suppl XIII):269, 1988. 7. Lenz H-J, Brunner T, Schlag H, Pawelec G, Ehninger G: Phase I study of continuous IV n-IL-2. Blut 61:p. 165, A380, 1990. 8. Lenz H-J, Reichmann U, Waller HD: Autoimmune hemolytic anaemia in a patient with polycythemia vera: first description. Blut 61:p. 196, A501, 1990. 9. Horikoshi T, Danenberg KD, Volkenandt M, Lenz H-J, Simoneau A, Jones PA, Bertino JR, Danenberg PV: Characterization of p53, thymidine kinase, and dihydrofolate reductase gene mutations by analysis of RNA conformational polymorphisms. Proc AACR 33:2392, 1992. 10. Lenz H-J, Horikoshi R, Danenberg KS, Gustavsson B, Leichman LP, Danenberg PV: A carcinoid tumor lacking thymidylate synthase (TS) activity expresses a truncated TS mRNA. Proc AACR 33:A88, 1992. 11. Leichman LP, Danenberg PV, Leichman CG, Lenz H-J, Danenberg KD, Baranda J, Kornmann M: Intratumoral thymidylate synthase expression and response to 5- fluorouracil (5FU)-leucovorin (LV) in patients with colorectal cancer. Proc AACR 34:A2103, 1993. 12. Lenz H-J, Danenberg KD, Manno DJ, Danenberg PV: Inhibition of eukaryotic mRNA splicing by 5-fluorouracil (FU)-substituted snRNA. Proc AACR 34:A2085, 1993. 13. Lenz H-J, Leichman CG, Danenberg P, Silberman H, Horikoshi T, Kiyabu M, Danenberg K, Spears CP, Laine L, Fuerst M, Leichman LP: Thymidylate synthase gene expression predicts response of primary gastric cancer to 5-fluorouracil (5FU)- leucovorin-cisplatin (DDP). Proc ASCO 12:A585, 1993. 14. Lenz H-J, Schnieders B, Danenberg KD, Goker E, Shane B, Bertino JR, Danenberg PV: A polymerase chain reaction assay for folylpolyglutamate synthetase (FPGS) gene expression: marked variation in human leukemia blast samples. Proc AACR 34:A3004, 1993. 15. Schmittgen TD, Danenberg KD, Horikoshi T, Lenz H-J, Danenberg PV: Effect of 5- fluoro-and 5-bromouracil-substituted mRNA on the translation of human thymidylate synthase. Proc AACR 34:A2478, 1993. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 100 of 173

16. Schmittgen TD, Ju JF, Danenberg KD, Lenz H-J, Danenberg PV: Cisplatin inhibits pre-mRNA splicing in a mammalian nuclear extract. Proc AACR 34:A2400, 1993. 17. Johnston PG, Lenz H-J, Danenberg KD, Leichman LP, Leichman CG, Allegra CJ, Danenberg PV: Thymidylate synthase protein and gene expression predicts for response to 5-fluorouracil, leucovorin chemotherapy in patients with colorectal and gastric cancer. Proc ASCO 13:A569, 1994. 18. Leichman CG, Lenz H-J, Leichman LP, Baranda J, Danenberg KD, Groshen S, Boswell W, Silberman J, Garcia Y, Danenberg PV: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer resistance to protracted infusion 5-fluorouracil and weekly leucovorin. Proc ASCO 13:A592, 1994. 19. Lenz H-J, Danenberg KD, Schnieders B, Bertino JR, Danenberg PV: Improved RNA- SSCP analysis of p53 mutations. Proc AACR 35:A3600, 1994. 20. Lenz H-J, Danenberg KD, Uziely B, Muggia FM, Danenberg PV: Co-regulation of thymidylate synthase (TS) and MDR in patients with breast cancer? Proc ASCO 13:A298, 1994. 21. Manno DJ, Lenz H-J, Danenberg KD, Danenberg PV: Splicing behavior of 5- fluorouracil (FU)-substituted precursor-mRNA. Proc AACR 35:A2675, 1994. 22. Uziely B, Delaflor-Weiss E, Lenz H-J, Groshen S, Jeffers S, Watkins K, Danenberg KD, Russell C, Leichman CG, Muggia FM, Press M: Paclitaxel (Taxol) in refractory breast cancer: response correlates with low levels of MDR1 gene expression. Proc ASCO 13:A104, 1994. 23. Banerjee D, Lenz H-J, Schnieders B, Kheradpour A, Manno DJ, Danenberg KD, Danenberg PV, Bertino JR: Transfection of wild type but not mutant p53 induces early monocytic differentiation in HL60 cells. Proc AACR 36:A295, 1995. 24. Formenti SC, Uziely B, Dunnington G, Spicer DV, Krecker E, Lenz H-J, Groshen S, Watkins K, Danenberg KD, Danenberg P, Leichman CG, Muggia FM: Continuous infusion (CI) 5-fluorouracil (FU) with radiation in locally advanced breast cancer: clinico-pathological and biological correlates. Proc ASCO 14:A358, 1995. 25. Lenz H-J, Danenberg KD, Leichman LP, Leichman CG, Danenberg PV: p53 Status predicts for response to 5-fluorouracil/leucovorin in patients with advanced colon cancer. Proc AACR 36:A3332, 1995. 26. Lenz H-J, Ju J-F, Danenberg KD, Banerjee D, Bertino JR, Danenberg PV: Effect of p53 activity on the cytotoxicity of 5-fluoro-2'-deoxyuridine and its inhibition of thymidylate synthase. Proc AACR 36:A121, 1995. 27. Lenz H-J, Ju J-F, Danenberg KD, Leichman LP, Leichman CG, Haag C, Danenberg PV: TS levels and p53 function predicts for response to 5-fluorouracil/leucovorin in patients with advanced colon cancer. Proc ASCO 14:A487, 1995. 28. Banerjee D, Lenz H-J, Hochhauser D, Danenberg K, Danenberg PV, Bertino JR: A role of p53 in the G2/M checkpoint in HL60 cells following radiation damage. Proc AACR 37:A4167, 1996. 29. Formenti SC, Lenz H-J, Dunnington G, Johnston P, Keren-Rosenberg S, Spicer DV, Danenberg K, Danenberg P: Initial p53 status as potential predictor for pathological response to the combination of 5FU and radiotherapy in locally advanced breast cancer. Proc ASCO 15:174, 1996. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 101 of 173

30. Hayashi K, Danenberg KD, Metzger R, Solonga D, Lenz H-J, Leichman CG, Danenberg PV, Leichman LP: Differential thymidylate synthase (TS) gene expression in squamous cell carcinoma and adenocarcinoma of the esophagus. Proc ASCO 15:499, 1996. 31. Hayashi K, Metzger R, Danenberg KD, Lenz H-J, Leichman LP, Danenberg PV: Quantitative and qualitative analysis of p16 gene expression in esophageal tumors by RT-PCR. Proc AACR 37:A43, 1996. 32. Ju J-F, Lenz H-J, Danenberg KD, Schonthal A, Banerjee D, Bertino JR, Danenberg PV: The cell-cycle arresting agent mimosine is selectively cytotoxic to cells lacking functional p53. Proc AACR 37:A14, 1996. 33. Lenz H-J, Danenberg KD, Danenberg PV, Johnston P, Florentine B, Leichman CG, Hayashi K, Metzger R, Leichman LP: p53 Status and thymidylate synthase (TS) expression are associated and predict for recurrence in patients with stage II colon cancer (CC). Proc ASCO 15:A501, 1996. 34. Lenz H-J, Danenberg KD, Leichman CG, Hayashi K, Metzger R, Salonga D, Banerjee D, Bertino JR, Leichman LP, Danenberg PV: p53 Point mutation thymidylate synthase (TS) gene expression and clinical response in gastrointestinal cancer. Proc AACR 37:A1351, 1996. 35. Lenz H-J, Danenberg KD, Leichman CG, Hayashi K, Metzger R, Salonga D, Kortes V, Banerjee D, Bertino JR, Groshen S, Leichman LP, Danenberg PV: p53 Status and thymidylate synthase levels are predictors of chemotherapy efficacy in patients with advanced colorectal cancer. Proc ASCO 15:A504, 1996. 36. Metzger R, Danenberg KD Danenberg PV, Hayashi K, Lenz H-J, Groshen S, Leichman CG, Baranda J, Crookes P, Laine L, Leichman LP: Excision repair cross complementing (ERCC)-1 gene in primary gastric cancer: A determinant of response to cisplatin-based chemotherapy. Proc ASCO 15:A505, 1996. 37. Metzger R, Danenberg KD, Hayashi K, Lenz H-J, Groshen S, Leichman CG, Baranda J, Crookes P, Laine L, Danenberg PV, Leichman LP: ERCC1 expression correlates with response of primary gastric cancer to cisplatin-based chemotherapy. Proc AACR 37:A1350, 1996. 38. Danenberg PV, Metzger R, Hayashi K, Salonga D, Danenberg KD, Kelsen D, Schwartz G, Fink U, Sendler A, Lenz H-J, Leichman LP: Lower TS expression in esophageal squamous cell carcinoma (ESCC) than in esophageal adenocarcinoma (EAC) is associated with different response rates to 5-fluorouracil-based protocols. Proc ASCO 16:A919, 1997. 39. Danenberg KD, Metzger R, Salonga D, Lenz H-J, Leichman LP, Leichman CG, Baranda J, Schwartz EL, Wadler D, Danenberg PV: Thymidine phosphorylase expression in colorectal tumors together with that of thymidylate synthase predict tumor responses to 5-fluorouracil. Proc AACR 38:A4127, 1997. 40. Elwell A, Xiong Y-P, Chang M, Leichman CG, Johnston OG, Groshen S, Leichman LP, Beart RW, Lenz H-J: p53, p21 and thymidylate synthase protein expression: associations with recurrence in stage II and III rectal cancer. Proc ASCO 16:A915, 1997. 41. Farrugia DC, Danenberg KD, Cunningham D, Metzger R, Danenberg PV, Lenz H-J, Aherne GW, MacVicar D, McCarthy K, Norman AR, Jackman AL: Predictors of Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 102 of 173

response and toxicity in patients with advanced colorectal cancer (CRC) treated with tomudex. Proc ASCO 16:952, 1997. 42. Formenti SC, Dunnington G, Lenz H-J, Russell CR, Silberman H, Spicer DV, Groshen S, Watkins K, Muggia FM, Press M, Danenberg PV: Original p53 status predicts for pathological response to 5-fluorouracil and radiation in locally advanced breast cancer. J Clin Oncol 16:A590, 1997. 43. Ju J-F, Kane SE, Lenz H-J, Danenberg KD, Danenberg PV: Sensitization of tumors to fluoropyrimidines with antisense against thymidylate synthase. Proc AACR 38:A3196, 1997. 44. Lenz H-J, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Danenberg PV, Leichman LP: P53 and TS expression in untreated stage II colon cancer: association with recurrence, survival, and tumor site. Proc AACR 38:A4123, 1997. 45. Lenz H-J, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Danenberg PV, Leichman LP: p53 and TS expression in untreated stage II colon cancer: association with recurrence, survival and tumor site. Proc ASCO 16:A1997, 1997. 46. Xiong Y-P, Danenberg KD, Metzger R, Salonga D, Groshen S, Danenberg PV, Davies MM, Allen-Merch TG, Lenz H-J: Thymidylate synthase (TS) mRNA levels predict for survival and response to hepatic artery infusion (HAI) with FUDR in patients with colorectal liver metastases. Proc ASCO 16:A918, 1997. 47. Lenz H-J, Xiong Y-P, Udalve A, Chang M, Leichman LP, Beart RW, Anton P, Kam L: Thymidylate synthase (TS) and ERCC1 MRNA expression in patients with inflammatory bowel disease (IBD). Proc ASCO 17:562a, 1998. 48. Perry S, McGregor JR, Morrel F, Lenz H-J: Transfection with wild-type p53 prevents nitric oxide-induced arrest and apoptosis of HL-60 leukemia cells. Nitric Oxide 2:121, 1998. 49. Shibata S, Doroshow JH, Lin S, Chu D, Pezner R, Chow W, Leong L, Morgan R, Margolin K, Raschko J, Somlo G, Tetef M, Yen Y, Wagman L, Longmate J, Toth L, Danenberg KD, Danenberg PV, Lenz H-J, Carroll M: RT-PCR analysis of thymidylate synthetase (TS), ribonucleotide reductase (RR), and ERCC-1 expression in patients (PTS) with locally advanced gastrointestinal (GI) malignancies treated with surgery, intraoperative radiation therapy (IORT) with concurrent 5-FU and external beam radiation (EBRT) with prolonged 5-FU infusion. Proc ASCO 17:562a, 1998. 50. Xiong Y-P, Udalve A, Chang M, Leichman LP, Leichman CG, Beart RW, Kam L, Anton P, Lenz H-J: Thymidylate synthase (TS), COX-1 and COX-2 gene expression levels in active and inactive mucosae in patients with imflammatory bowel disease (IBD). Proc AACR 39:488, 1998. 51. Garcia AA, Leichman L, Baranda J, Lenz H-J, Angeles A, DeJong L, Leichman CG: Phase II study of trimetrexate (neutrexin), 5-fluorouracil, and leucovorin (NFL) in Advanced Pancreatic. Proc ASCO 18:971, 1999. 52. Lenz H-J, Habashy M, Xiong Y-P, Lynch R, Cardonna S, Pullarkat S, Tsao-Wei D, Ladner R: dUTPase expression in GI cancer: associations with response and survival. Proc ASCO 18:970, 1999. 53. Reddy GR, Gandara DR, Edelman MJ, Doroshow JH, Lau D, Lenz H-J, Israel V, Albain K, Jaslowski A, Lauder I, Conklin T, Maryon T: Gemcitabine (GEM) in Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 103 of 173

platinum (PLAT) treated non-smallcell lung cancer (NSCLC). Proc ASCO 18:2007, 1999. 54. Synold TW, Newman E, Lenz H-J, Gandara DR, Chow W, Leong L, Morgan Jr R, Raschko J, Shibata S, Leichman CG, Carroll M, Longmate J, Doroshow JH: Prospective evaluation of docetaxel (D) pharmacokinetics (PK) and toxicity in patients with tumor-related hepatic dysfunction (HD). Proc ASCO 18:643, 1999. 55. Synold TW, Spicer DV, Muggia F, Tetef M, Gandara DR, Groshen S, Lenz H-J, Newman EM, Johnson K, Doroshow JH: The pharmacokinetics of paclitaxel (P) are unaffected by the multidrug resistance (MDR) reversing agent SDZ PSC 833 (PSC) in patients (PTS) with metastatic breast cancer (BC) despite an improvement in overall response rate. Proc AACR 40:344, 1999. 56. Tetef ML, Doroshow JH, Synold T, Leichman CG, Lenz H-J, Gandara DR, Longmate J, Maryon T, Ter Veer A, Groshen S, Carrol M, Chow W, Leong L, Margolin K, Morgan R, Raschko J, Shibata S, Somlo G, Yen Y: Phase I study of 96 hour (hr) continuous infusion (CI) of dexrazoxane (DEX) followed by 72 hour CI of in patients (PTS) with advanced malignancies. Proc ASCO 18:884, 1999. 57. Xiong Y-P, Bochner B, Lieskovsky G, Johnston P, Groshen S, Lenz H-J: p53 and thymidylate synthase (TS): potential prognostic indicators of survival in patients with localized prostate cancer. Proc ASCO 18:1216, 1999. 58. Doroshow JH, Tetef M, Margolin K, Somlo G, Frankel P, Longmate J, Synold T, Gandara DR, Lenz H-J, Albain KS: Significant activity of gemcitabine (GEM) and cisplatin (DDP) in both heavily (H) and minimally (M)-pretreated metastatic breast cancer (MBC) patients (PTS): a California Cancer Consortium/Loyola University Chicago trial. Proc ASCO 19:609H, 2000. 59. Ladner RD, Stoehlmacher J, Lynch FJ, Wei D, Xiong Y-P, Sherrod A, Caradonna SJ, Lenz H-J: DUTPase isoform expression in normal and neoplastic tissues: association with survival and response to 5-FU in colon and gastric cancer. Proc AACR 41:4056, 2000. 60. Lara Jr P, Gandara DR, Lau DH, Edelman MJ, Mack PC, Gumerlock PH, Lenz H-J, Israel V, Raschko J, Longmate J, Frankel P, Doroshow JH: Activity of high dose toremifene (TOR) plus cisplatin (CDDP) in advanced non-small-cell lung cancer (NSCLC): a phase II California Cancer Consortium trial. Proc ASCO 19:1983, 2000. 61. Law L, Lara Jr PN, Reddy GP, Edelman MJ, Doroshow JH, Lau DH, Lenz H-J, Israel V, Albain K, Longmate J, Frankel P, Gandara DR: Salvage gemcitabine (GEM) in platinum-treated non-small-cell lung cancer (NSCLC): a phase II California Cancer Consortium trial. Proc ASCO 19:2095, 2000. 62. Lenz H-J, Bupta M, Xiong Y-P, Synold T, Tsao-Wei D, Groshen S, Gandara DR, Koda RT, Doroshow JH: Phase I study of bryostatin-1 and cisplatin (CDDP). Proc ASCO 19:795, 2000. 63. Pullarkat ST, Ghaderi V, Ingles SA, Xiong Y-P, Chen P, Stoehlmacher J, Gupta M, Tsao-Wei D, Groshen S, Lenz H-J: Human thymidylate synthase gene polymorphism determines response to 5-FU chemotherapy. Proc ASCO 19:942, 2000. 64. Pullarkat ST, Xiong Y-P, Ingles SA, Sherrod A, Ghaderi V, Tsao-Wei D, Groshen S, Lenz H-J: Human thymidylate synthase gene polymorphism determines intratumoral thymidylate synthase mRNA level: implications for fluoropyrimidine chemotherapy. Proc AACR 41:4583, 2000. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 104 of 173

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experience of oxaliplatin as s single agent or in combination with 5-flourouracil in more than 7000 patients with previously treated advanced colorectal cancer. Onkologie 26(3):p21, A1065, 2003. 127. Iqbal S, Garber J, Yang D, Agafitei R, Groshen S, Lujan R, Garcia A, Kornowski A, Lenz H-J: Pilot trial of 5-FU/oxaliplatin (CIFOX) as a compassionate use regimen in patients with metastatic colorectal cancer: The USC experience. Onkologie 26(3):p39, A1510, 2003. 128. Padmanabhan A, Iqbal S, Stoehlmacher J, Yun J, Garcia A, Agafitei R, Yang D, Groshen S, Karnowski A, Lenz H-J: Pilot trial of 5-FU/oxaliplatin (CIFOX) for patients with metastatic colorectal cancer after progression with 5-FU/LV/CPT-11 (IFL). Onkologie 26(3):p39, A1511, 2003. 129. Leong LA, Frankel P, Juhasz A, Lawrence J, Lim D, Shibata S, Yen Y, Lenz H-J, Gandara DR, Doroshow JH: Ribonucleotide reductase M1 and M2 (RR-M1, -M2), cytidine deaminase (CDA), deoxycytidine deaminase (dCDA), deoxycytidine kinase (dCK), and excision repair cross complementation – 1 (ERCC-1) expression in advanced malignancies treated with combined oxaliplatin and gemcitabine. Onkologie 26(3):p46, A3456, 2003. 130. Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Yu MC, Iqbal S, Lenz HJ, Ladner RD. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 14(5):319–327. May 2004. 131. Iqbal S, Cole S, Yang D, Lara PN, Gumerlock PH, Shibata S, Synold T, Doroshow JH, Gandara D, Lenz HJ: Phase I study of PS-341 (bortezomib) with 5- fluorouracil/leucovorin (5-FU/LV) in advanced solid tumors: A California Cancer Consortium study. Proc ASCO 23:2057, 2004. 132. Ishioka GY, Disis ML, Morse MA, Cunningham CC, Lenz H-J, Figlin RA, Chesnut RW, Fikes J: A phase I trial of a multi-epitope cancer vaccine (EP-2101) in non-small cell lung (NSCLC) and colon cancer patients. Proc ASCO 23:2525, 2004. 133. Levine AM, Quinn DI, Gorospe G, Lenz HJ, Tulpule A: Phase I trial of anti-sense oligonucleotide vascular endothelial growth factor (VEGF-AS, Veglin) in patients with relapsed and refractory malignancies. Proc ASCO 23:3008, 2004. 134. Pegram M, Yeon CH, Ku N, Gottlieb C, Shepard M, Cossum P, John E, Iqbal S, Garcia A, Lenz HJ. Enzyme catalyzed therapeutic activation of NB1011 (N) selectively targets thymidylate synthase (TS)-overexpressing tumor cells: Phase I results. Proc ASCO 23:3144, 2004. 135. Lenz HJ, Mayer RJ, Gold PJ, Mirtsching B, Stella PJ, Cohn AL, Pippas AW, Azarnia N, Needle MN, Van Cutsem E: Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. Proc ASCO 23:3510, 2004. 136. Zhang W, Yun J, Press OA, Gordon M, Yang DY, Mallik N, Sherrod S, Iqbal S, Lenz HJ: Association of cyclin D1 (CCND1) gene A870G polymorphism and clinical outcome of EGFR-positive metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab (C225). Proc ASCO 23:3518, 2004. 137. Yun J, Zhang W, Park D, Yang D, Press O, Gordon M, Mallik N, Lenz HJ: Molecular profiling predicts clinical outcome in patients with metastatic colorectal cancer treated with 5-FU/oxaliplatin. Proc ASCO 23:3519, 2004. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 110 of 173

138. Dragovich T, Lenz HJ, Rocha Lima CMS, Kozuch P, Hochster H, O’Neil B, Atiq O, Pipas JM, Kashala O, Schenkein DP: Bortezomib ± irinotecan in relapsed/refractory colorectal cancer (CRC): Interim analysis results from phase (ph) 2b study. Proc ASCO 23:3591, 2004. 139. Agafitei RD, Schneider S, Iqbal S, Yang D, Groshen S, Lenz HJ: Effect of celecoxib on neurotoxicity in patients with metastatic colorectal cancer treated with 5- FU/oxaliplatin (CIFOX). Proc ASCO 23:3600, 2004. 140. Gordon MA, Zhang W, Yang DY, Gil J, Yun J, Press O, Mallik N, Lenz HJ: McSOD and GPx-1 polymorphisms in relation to local recurrence in patients with rectal cancer treated with chemoradiation. Proc ASCO 23:3604, 2004. 141. Mallik N, Zhang W, Yang DY, Iqbal S, Yun J, Press O, Gordon M, Lenz H-J: Polymorphisms in IL-8 and the GSTP1 are associated with survival of metastatic colorectal cancer patients treated with CPT-11. Proc ASCO 23:3606, 2004. 142. Press OA, Zhang W, Yang DY, Yun J, Gordon M, Mallik N, Lenz H-J: Survival differences related to estrogen receptor beta (ERβ) polymorphism and age in female patients with metastatic colon cancer. Proc ASCO 23:3618, 2004. 143. Park DJ, Yun J, Yang DY, Iqbal S, Press O, Groshen S, Gordon M, Zhang W, Lenz H- J: Genomic profiling as predictor of toxicity in patients with advanced colorectal cancer treated with platinum-based chemotherapy. Proc ASCO 23:3627, 2004. 144. Aparicio A, Iqbal S, Yang D, Groshen S, Park D, Garcia A, Lenz HJ: Pilot trial of 5- FU/oxaliplatin (CIFOX) for patients with metastatic colorectal cancer who progressed on 5-FU/LV/CPT-11 (IFL). Proc ASCO 23:3773, 2004. 145. Yen Y, Doroshow J, Leong L, Lim D, Wagman L, Morgan R, Frankel P, Lenz H, Gandara D, Shibata S: Phase II study of oxaliplatin in patients with unresectable, metastatic or recurrent hepatocellular cancer. Proc ASCO 23:4169, 2004. 146. Yang D, Schneider S, Danenberg KD, Danenberg PV, Lenz H-J: Gene expressions of VEGF and Survivin as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. Proc ASCO 23:9526, 2004. 147. Iqbal S, Stoehlmacher J, and Lenz HJ: Tailored chemotherapy for colorectal cancer: a new approach to therapy. Cancer Invest. 22(5):762-773, 2004. 148. Zhang W, Vallboehmer D, Yun J, Press O, Gordon M, Rhodes K, Yang D, Iqbal S, Lenz H-J. Pharmacogenetic study of EGFR-positive metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab (C225). ASCO Proc Gastro Intestinal Cancers Symposium p.168:A169, 2005. 149. Saltz LB, Lenz H-J, Kindler H, Hochster H, Wadler S, Hoff P, Kemeney N, Hollywood E, Gonen M, Chen H. Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. ASCO Proc Gastro Intestinal Cancers Symposium p.169:A169b, 2005. 150. Kemeney NW, Niedzwiecki D, Hollis DR, Lenz H-J, Warren RD, Naughton MJ, Weeks JC, Herndon JE, Zhang K, Mayer RJ. Final analysis of hepatic arterial infusion (HAI) versus systemic therapy for hepatic metastases from colorectal cancer: a CALGB randomized trial of efficacy, quality of life (QOL), cost effectiveness, and molecular markers. ASCO Proc Gastro Intestinal Cancers Symposium p. 176:A183, 2005. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 111 of 173

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175. Press OA, Zhang W, Yang D, Haiman CA, Gordon M, Schultheis AM, Nagashima F, Sherrod A, Ibal S, Lenz H-J. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms associated with overall survival in women with metastatic colon cancer. Proc ASCO 24:3600, 2006. 176. Kobayashi H, Hashiguchi Y, Ueno H, Shinto E, KajiwaraY, Lenz H-J, Danenberg KD, Danenberg PV, Mochizuki H. Pretreatment COX-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy. Proc ASCO 24:3610, 2006. 177. Shimizu D, Kuramochi H, Tanaka K, Cooc J, Xiong Y, William M, Li R, Danenberg KD, Danenberg PV, Lenz H-J. Molecular signatures generated with RNA isolated from formalin-fixed paraffin-embedded tumor specimens differentiate metastatic and non-metastatic primary colorectal cancer. Proc ASCO 24:3615, 2006. 178. Zhang W, Gordon M, Schultheis A, Nagashima F, Azuma M, Yang D, Iqbal S, Lenz H-J. Two immunoglobulin G fragment C receptor polymorphisms associated with clinical outcome of EGFR-expressing metastatic colorectal cancer patients treated with single agent cetuximab. Proc ASCO 24:3028, 2006. 179. Rhodes KE, Zhang W, Yang DY, Gordon M, Schultheis A, Nagashima F, Iqbal S, Lenz H-J. Abcb1, ugt1a1 and oatp-c polymorphisms predict Irinotecan (CPT-11) toxicity. Proc ASCO 24:3074, 2006. 180. Park DJ, Zhang W, Gordon M, Yang DY, Ladner R, Iqbal S, Groshen S, Vallbohmer D, Lenz H-J, Fazzone W. Lack of association with epidermal growth factor receptor gene polymorphisms with clinical outcome in patients with advanced colorectal cancer treated with platinum-based chemotherapy. Proc ASCO 24:3079, 2006. 181. Ramanathan RK, Belani CP, Singh DA, Tanaka M, Lenz H-J, Yen Y, Kindler HL, Iqbal S, Longmate J, Gandara DR. Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. Proc ASCO 24: 4010, 2006. 182. Schultheis AM, Yang D, Garcia AA, Morgan R, Gandra D, Scudder S, Oza A, HIrte H, Fleming G, Roman L, Lenz H-J. Angiogenesis pathway gene polymorphisms associated with clinical outcome in recurrent ovarian cancer treated with low dose cyclophosphamide and bevacizumab: A California Consortium Trial. Proc ASCO 24:5017, 2006. 183. Tanaka K, Shimizu D, Kuramochi H, Cooc J, Williams M, Li R, Chen P, Danenberg KD, Danenberg PV, Lenz H-J. Molecular signatures generated with RNA Isolated from formalin-fixed paraffin-embedded tumor specimens differentiate metastatic and non-metastatic primary breast cancer. Proc ASCO 24:614, 2006. 184. Gordon M, Zhang W, Yang D, Spicer D, Doroshow J, Margolin K, Synold T, Albain K, Chew H, Gandara DR, Lenz H-J. Polymorphisms of DNA-repair genes associated with clinical outcome in metastatic breast cancer (MBC) patients treated with gemcitabine/cisplatin (GC) (California Cancer Consortium). Proc ASCO 24: 675, 2006. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 114 of 173

185. Takimoto CH, Liu PY, Lenz H-J, Remick S, Mulkerin D, Mani S, Synold T, Ramanathan RK, Ivy P, Davies AM. A phase I pharmacokinetic (PK) study of the Epothilone B analogue, ixabepilone (BMS-247550) in patients (pts) with advanced malignancies and varying degrees of hepatic impairment. A SWOG Early Therapeutics Committee and NCI Organ Dysfunction Working Group Trial. Proc ASCO 24:2004, 2006. 186. Beumer JH, Parise RA, Newman EM, Doroshow JH, Synold T, Lenz H-J, Egorin MJ. Concentration of the DNA methyltransferase inhibitor 5-flouro-2’-deoxycy-ticine (FdCyd) & its metabolites 5-flouro-2’-deoxyuridine (FdUrd), 5-flourouracil (FU), 5- flourouridine (FUrd), & 5-flourocytosine (FC) in plasma of patients treated with FdCyd. Proc ASCO 24:2023, 2006. 187. Yang D, Vallbohmer D, Zhang W, Iqbal S, El-Khoueiry A, Gordon M, Park D, Azuma M, Groshen S, Danenberg K, Lenz H-J. Intratumoral mRNA levels predict clinical outcome in patients with metastatic colorectal cancer treated in a prospective clinical trial with 5-FU and oxaliplatin. Proc ASCO 24:10010, 2006. 188. Shaye O, El-Khoueiry A, Garcia A, Wei D, Groshen S, Cole S, Gitlitz B, Chung C, Lenz H-J, Iqbal S. Phase I dose and schedule finding study of pegylated liposomal (D) and weekly docetaxel (T). Proc ASCO 24:12012, 2006. 189. Singh D, Taber D, Ansari R, Lenz H-J, Agamah E, Nattam S, Wade-Oliver K, Kasza K, Volkes E, Kindler H. A phase II trial of the epothilone B analog BMS-247550 in patients (pts) with hepatobiliary cancer (HBC): An updated analysis. Proc ASCO 24:14050, 2006. 190. Zhang W, Gordon M, Press O, Rhodes K. Vallbohmer D, Yang D, Park D, Fazzone W, Schultheis A, Sherrod A, Iqbal S, Groshen S, Lenz H-J. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. Pharmacogenetics and Genomics. 16(7):475- 83, July 2006. 191. Love N, Bylund C, Meropol NJ, Marshall J, Curley SA, Ellis LM, Grothey A, Lenz H- J, Saltz LB, Elder M. How well do we communicate with out patients? A survey of patients who received adjuvant chemotherapy for colorectal cancer. Presented at: ASCO GI poster session, 239. Orlando, FL. 1/21/07. 192. Lenz H-J, Zhang W, Yang D, Carpanu M, Hollywood E, Lue-Yat M, Azuma M, Nagashima F, Chang H, Saltz L. Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotacan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. Presented at: ASCO GI poster session, 401. Orlando, FL. 1/21/07. 193. Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz H-J, Danenberg K, Danenberg P. Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis. Presented at: ASCO GI poster session, 429. Orlando, FL. 1/21/07. 194. Rhodes K, Zhang W, Yang D, Press O, Gordon M, Vallbohmer D, Schultheis A, Lurje G, Ladner R, Fazzonne W, Iqbal S, Lenz H-J. ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line Irinotecan. Drug Metabolism Letters 1: 23-30, 2007. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 115 of 173

195. DePrimo S, Harmon C, Saltz L, Lenz H-J, Marchall J, Rosen L, Belt R, Hurwitz H, Eckhardt S, Bergsland E, Lockhart A, Lima C, Smeraglia J, Maneval E, Chao R. Variations in circulating levels of VEGF and sVEGFR-2, sVEGFR-3 and sKIT in metastatic CRC patients treated with Sunitinib and failure of prior chemotherapy with or without Bevacizumab. AACR 9053. 4/14-18/2007. 196. LaBonte M, Wilson P, Fazzone W, Lenz H-J, Ladner R. The effects of histone deacetylase inhibitors on epidermal growth factor receptor expression in colon cancer cell lines: implications for combination therapy. AACR 683. 4/14-18/2007. 197. Fazzone W, Borucka E, Lenz H-J, Ladner R. Histone deacetylase inhibitors downregulate thymidylate synthase expression and interact synergistically with floouropyrimidines in colon cancer cell lines. AACR poster session 692. 4/14-18/2007. 198. Lenz H-J. Clinical research Track: Phase I-III trials Phase III clinical plenary session: Breakthroughs in clinical research. AACR Discussant. 4/16/2007. 199. Love N, Bylund C, Meropol NJ, Marshall JL, Curley SA, Ellis LM, Grothey A, Lenz H-J, Saltz LB, Elder MA. How well do we communicate with patients concerning adjuvant systemic therapy? A survey of 150 colorectal cancer survivors. Proc ASCO 25:4020, 2007. 200. Hoffman AC, Hoffman C, Danenberg KD, Lenz H-J, Danenberg PV. Heparanase and Survivin-potential markers of aggressiveness of colon cancers. Proc ASCO 25:14524, 2007. 201. Lurje G, Schultheis AM, Hendifar AE, Shouri S, Zhang W, Gordon MA, Nagashima F, Chang HM, Yang D, Lenz H-J. VEGF and VEGF receptor-2 (VEGFR2) gene polymorphisms predict tumor recurrence in stage II and III colon cancer. Proc ASCO 25:4004, 2007. 202. Yang D, Schultheis AM, Lurje G, Iqbal S, Chang H, Zhang W, Gordon M, Nagashima F, Lenz H-J. Tissue factor promoter polymorphisms as a prognostic factor in patients with metastatic colon cancer. Proc ASCO 25:4108, 2007. 203. Omori A, Stephens C, Cooc J, Danenberg PV, Danenberg K, Lenz H-J, Pasche B. Microarray analysis of formalin-fixed paraffin embedded specimens shows distinct gene expression patterns in tumors containing the transforming growth factor beta receptor 6A polymorphism (TGFBR1*6A). Proc ASCO 25:4111, 2007. 204. Azuma M, Yang D, Carpanu M, Hollywood E, Leu-Yat M, Zhang W, Danenberg KD, Danenberg PV, Saltz L, Lenz H-J. Molecular markers associated with response and clinical outcome to cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer (BOND2). Proc ASCO 25:4113, 2007 205. Gordon MA, Zhang W, Yang D, Nagashima F, Chang H, Lurje G, Borucka E, Lenz H- J. Use of sex-specific genomic profile to predict clinical outcome in metastatic colorectal cancer (mCRC) patients treated with 5-flourouracil/oxaliplatin. Proc ASCO 25:4122, 2007. 206. Zhang W, Yang D, Capanu M, Hollywood E, Leu-Yat M, Borucka E, Azuma M, Gordon M, Saltz L, Lenz H-J. Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. Proc ASCO 25:4128, 2007. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 116 of 173

207. Nagashima F, Zhang W, Gordon M, Chang HM, Lurje G, Borucka E, Yang D, Ladner R, Rowinsky E, Lenz H-J. EGFR, Cox-2, and EGF polymorphisms associated with progression-free survival of EGFR-expressing metastatic colorectal cancer patients treated with single-agent cetuximab (IMCL-0144). Proc ASCO 25:4129, 2007. 208. Ladner R, Gordon MA, Zhang W, Yang D, Nagashima F, Chang H, Lurje G, Borucka E, Lenz H-J. Polymorphisms in estrogen receptor beta, interleukin-8, and interleukin-8 receptor associated with clinical outcome in metastatic colorectal cancer (mCRC) patients treated with 5-flourouracil/oxaliplatin. Proc ASCO 25:4130, 2007. 209. Iqbal S, Goldman B, Lenz HJ, Fegnolio-Preiser CM, Blanke CD. S0413: A phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients (pts) with advanced or metastatic gastric cancer. Proc ASCO 25:4621, 2007. 210. El-Khoueiry AB, Rankin C, Lenz H-J, Philip PA, Rivkin SE, Blanke CD. SWOG 0514: A phase II study of sorafenib (BAY 43-9006) as single agent in patients (pts) with unresectable or metastatic gallbladder cancer or cholangiocarcinomas. Proc ASCO 25:4639, 2007. 211. Chang H, Azuma M, Goldman B, Nagashima F, Iqbal S, Danenberg K, Benedetti J, Zhang W, Blanke C, Lenz H-J. Gene expression levels of HER2 and IL-8 and polymorphisms in IL-8 associated with clinical outcome in advanced or metastatic gastric cancer treated with lapatinib in SWOG 0413 trial. Proc ASCO 25:4647, 2007. 212. Lara P, Redman M, Lenz H-J, Gordon M, Shibata T, Fukuda H, Tamura T, Saijo N, Natale R, Gandara D. Cisplatin (Cis)/etoposide (VP 16) compared to cis/irinotecan (CPT 11) in extensive-stage small cell lung cancer (E-SCLC): Pharmacogenomic (PG) and comparative toxicity analysis of JCOG 9511 and SWOG 0124. Proc ASCO 25:7524, 2007. 213. Philip PA, Benedetti J, Fegnolio-Preiser C, Zalupski M, Lenz H-J, O’Reilly E, Wong R, Atkins J, Abruzzese J, Blanke C. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients (pts) with locally advanced or metastatic pancreatic adenocarcinoma [Pca]: SWOG S0205 study. Proc ASCO 25:LBA4509, 2007. 214. Shaye OS, Chang HM, Yang DY, Shriki J, Schultheis AM, Zhang W, Lurje G, Iqbal S, Lenz H-J, El-Khoueiry AB. Polymorphisms in angiogenesis related genes predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). Proc ASCO 25:10576, 2007. 215. Love N, Meropol NJ, Ravdin PM, Bylund C, Ellis LM, Grothey A, Lenz H-J, Marshall JL, Paley D, Elder M. Which adjuvant systemic treatments would medical oncologist wish to receive if they had colon cancer. A survey of 150 physicians. ASCO GI poster session. Orlando, FL. 1/25-27/08. 216. Wilson PM, Yang D, Shi MM, Zhang W, Jacques C, Barret J, Danenberg K, Trarbach T, Folprecht G, Meinhardt G, Lenz H-J. Intratumoral mRNA expression of genes involved in angiogenesis and H1F1 pathway predict outcome to VEGFR tyrosine kinase inhibitor (TK1) in patients enrolled in CONFIRM1 and CONFIRM2. ASCO GI poster session. Orlando, FL. 1/25-27/08. 217. Lenz H-J, Zhang W, Shi MM, Jacques C, Barrett J, Danenberg K, Hoffman AC, Trarbach T, Folprecht G, Meinhardt G, Yang D. ERCC-1 gene expression levels predict outcome to FOLFOX chemotherapy in patients enrolled in CONFIRM1 and CONFIRM2. ASCO GI poster session. Orlando, FL. 1/25-27/08. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 117 of 173

218. Zhang W, Rankin C, Danenberg K, Benedetti JK, Danenberg P, Ulrich CM, Holmes RS, Makar KW, Blanke C, Smalley SR, Lenz H-J. An update of pharmacogenetic analysis of adjuvant rectal cancer patients treated with 5-flourouracil and pelvic radiation in a phase III intergroup trial (INT-0144, SWOG 9304). ASCO GI poster session. Orlando, FL. 1/25-27/08. 219. Ning Y, Zhang W, El-Khoueiry A, Danenberg K, Yang D, Singh H, Lurje G, Pohl A, Manegold P, Iqbal S, Lenz H-J. K-RAS mutation status predicts clinical outcome in metastatic colorectal cancer (mCRC) patients treated with first line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV respectively). ASCO GI poster session. Orlando, FL. 1/25-27/08.3 220. Manegold PC, El-Khoueiry AB, Lurje G, Singh H, Yang D, Zhang w, Chang H, Shriki J, Pohl A, Iqbal S, Lenz H-J. ICAM-1, GRP-78 and NFkB gene polymorphisms associated with clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). ASCO GI poster session. Orlando, FL. 1/25-27/08. 221. Husain H, Lurje G, Yang D, Zhang W, Hendifar AE, Ashouri S, Pohl A, Manegold P, Iqbal S, El-Khoueiry A, Lenz H-J. Ethnicity is associated with recurrence in patients with resected gastric cancer. ASCO GI poster session. Orlando, FL. 1/25-27/08. 222. Pohl A, Lurje G, Zhang W, Yang D, Hendifar AE, Manegold PC, Ning Y, Iqbal S, El- Khoueiry A, Lenz H-J. Polymorphisms in interleukin-1 b (IL-1b) and IL-1 receptor antagonist (IL-1Ra) predict tumor recurrence in stage II colon cancer. ASCO GI poster session. Orlando, FL. 1/25-27/08. 223. Lurje G, Husain H, Hendifar A, Zhang W, Yang D, Pohl A Manegold P, Ning Y, Iqbal S, El-Khoueiry A, Lenz H-J. Thrombin-receptor 1 (PAR-1), Endostatin (ES), and Interleukin-8 (IL-8) gene polymorphisms predict tumor recurrence in patients with surgically resected gastric cancer. ASCO GI poster session. Orlando, FL. 1/25-27/08. 224. Yang D, Lenz C, Togawa K, Lurje G, Pohl A, Manegold P, Ning Y, Groshen S, Lenz H-J. Age and ethnicity predict overall survival in patients with metastatic gastric cancer. ASCO GI poster session. Orlando, FL. 1/25-27/08. 225. Hendifar A, Lurje G, Lenz F, Pohl A, Manegold P, Togawa K, Husain H, Lenz H-J, Yang D. Sex, age and ethnicity are associated with survival in metastatic colorectal cancer. ASCO GI poster session. Orlando, FL. 1/25-27/08. 226. El-Khoueiry AB, Iqbal S, Feit K, Lenz H-J, Okereke C, Krivelevich I, Goldberg T, Conti P, Rossignol D. A phase I study of E7820 in combination with Cetuximab in patients (pts) with advanced solid tumors. Proc ASCO 26:3568, 2008. 227. Wilson PM, Yang D, Shi MM, Zhang W, Jacques C, Barrett JC, Danenberg K, Trarbach T, Folprecht G, Meinhardt G, Lenz H-J. Use of intratumoral mRNA expression of genes involved in angiogenesis and HIF1 pathway to predict outcome to VEGFR tyrosine kinase inhibitor (TKI) in patients enrolled in CONFIRM1 and CONFIRM2. Proc ASCO 26:4002, 2008. 228. Hendifar AE, Lurje G, Lenz F, Pohl A, Manegold PC, Togawa K, Husain H, Lenz H-J, Yang D. Sex, age and ethnicity are associated with survival in metastatic colorectal cancer. Proc ASCO 26:4015, 2008. 229. Love N, Meropol NJ, Ravdin PM, Bylund C, Ellis LM, Grothey A, Lenz H-J, Marshall JL, Curly SA, Paley D, Elder M. Which adjuvant systemic treatment (AdjRx) would Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 118 of 173

medical oncologist (MOs) wish to receive if they had colon cancer (CCa)? A survey of 150 physicians. Proc ASCO 26:4049, 2008. 230. Zhang W, Rankin CJ, Danenberg K, Benedetti J, Danenberg P, Ulrich C, Holmes R, Makar K, Blanke C, Smalley S, Lenz H-J. An update of pharmacogenetic analysis of adjuvant rectal cancer patients treated with 5-flourouracil and pelvic radiation in a phase III intergroup trial (INT-0144, SWOG 9304). Proc ASCO 26: 4115, 2008. 231. Lenz H-J, Zhang W, Shi M, Jacques C, Barrett JC, Danenberg KD, Hoffman AC, Trarbach T, Folprecht G, Meinhardt G, Yang D. ERCC-1 gene expression levels and outcome to FOLFOX chemotherapy in patients enrolled in CONFIRM1 and CONFIRM2. Proc ASCO 26:4131, 2008. 232. Manegold PC, El-Khoueiry AB, Lurje G, Singh H, Yang D, Zhang W, Chang H, Shriki J, Pohl A, Iqbal S, Lenz H-J. ICAM-1, GRP-78, and NFkB gene polymorphisms and clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). Proc ASCO 26: 4134, 2008. 233. Pohl A, Lurje G, Zhang W, Yang D, Hendifar A, Manegold PC, Ning Y, Iqbal S, El- Khoueiry AB, Lenz H-J. Use of polymorphisms in interleukin-1 β (IL-1 β) and IL-1 receptor antagonist (IL-1Ra) to predict tumor recurrence in stage II colon cancer. Proc ASCO 26:4138, 2008. 234. Gold PJ, Goldman B, Iqbal S, Leichman LP, Lenz H-J, Blanke C. Cetuximab as second-line therapy in patients with metastatic esophageal cancer: A phase II Southwest Oncology Group Study. Proc ASCO 26:4536, 2008. 235. Lurje G, Husain H, Hendifar A, Zhang W, Yang D, Pohl A, Manegold P, Ning Y, Iqbal S, El-Khoueiry A, Lenz H-J. Use of thrombin-receptor 1 (PAR-1), endostatin (ES), and interleukin-8 (IL-8) gene polymorphisms to predict tumor recurrence in patients with surgically resected gastric cancer. Proc ASCO 26: 4559, 2008. 236. Natale R, Lara P, Chansky K, Crowley J, Jett J, Carleton J, Kuebler J, Lenz H-J, Mack P, Gandara D. S014: A randomized phase III trial comparing irinotecan/cisplatin (IP) with etoposide/cisplatin (EP) in patients (pts) with previously untreated extensive stage small cell lung cancer (E-SCLC). Proc ASCO 26:7512, 2008 237. Iqbal S, Lenz H-J, Yang D, Ramanthan R, Bahary N, Shibata S, Morgan R, Gandara D. A randomized phase II study of BAY 43-9006 in combination with gemcitabine in metastatic pancreatic carcinoma: A California Cancer Consortium study (CCC-P). Proc ASCO 26:11082, 2008. 238. Lenz H-J. Biomarkers in Colorectal Cancer. Clinical Spotlight, Supplement to Oncology Times. (guest editor) 6/10/08. 239. Abbruzzese JL, Lenz H-J, Hanna W, Kindler HL, Scullin D, Nemunaitis J, Kudva G, Zhang J, Zergebel C, Urrea P. Open-label phase II study of S-1 as second-line therapy for patients with metastatic pancreatic cancer. ASCO GI poster session. San Francisco, CA. 1/15-17/09. 240. Thomas CR, Goldman BH, Benedetti JK, Lenz H-J, Baker T, Hammond-Thelin L, Mehta VK, Fenoglio-Preiser CM, Abbruzzese JL, Blanke CD. Cetuximab (225) plus Cisplatin (CDDP), Irinotecan (CPT11) and Thoracic Radiotherapy (TRT) as Definitive Treatment for Locally Advanced, Clinically Unresectable Esophageal Cancer. SWOG 0414, ASTRO 2009. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 119 of 173

241. El-Khoueiry, A, Lenz HJ, Posey J, Wood T, Fischer B, Sankar V, Syed S, Kollia G, Masson E, Walters I. Effects of hepatic impairment on the pharmacokinetics of brivanib in a phase 1, open-label, multidose study in patients with hepatocellular carcinoma and other solid tumors. EASL poster session. Copenhagen, Denmark 4/22- 26/09. 242. Yang D, Pohl A, Zhang W, Lurje G, Ning Y, El-Khoueiry A, Khambata-Ford S, Langer C, Iqbal S, Lenz H. Pharmacogenetic analysis in metastatic colorectal cancer (mCRC) patients (pts) treated with second-line irinotecan (IR)+/- cetuximab (CB): The EPIC experience. Poster Discussion. Proc ASCO 27: 4022, 2009. 243. Ning Y, Lurje G, Danenberg K, Cooc J, Yang D, Pohl A, Zhang W, Lenz H. VEGF and VEGFR1 gene expression levels and tumor recurrence in adjuvant colon cancer. Poster Session. Proc ASCO 27: 4040, 2009. 244. Lenz H, Lurje G, Haiman CA, Yang D, Pohl A, Ning Y, El-Khoueiry A, Iqbal S, Zhang W. Colorectal cancer susceptibility variants and clinical outcome in adjuvant and metastatic colorectal cancer. Poster Session. Proc ASCO 27: 4051, 2009. 245. El-Khoueiry AB, Pohl A, Danenberg K, Cooc J, Zhang W, Yang D, Singh H, Shriki J, Iqbal S, Lenz HJ. Wt Kras and gene expression levels of VEGFR2, EGFR, and ERCC- 1 associated with progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). Poster Session. Proc ASCO 27: 4056, 2009. 246. Winder T, Zhang W, El-Khoueiry A, Yang D, Pohl A, Lurje G, Rowinsky E, Khambata-Ford S, Langer C, Awad M, Lenz H. Association of a germ-line variant in the K-ras 3' untranslated region with response and progression-free survival in patients with mCRC treated with single-agent cetuximab (IMCL-0144) or in combination with cetuximab (EPIC) independent of K-RAS mutation status. Poster Session. Proc ASCO 27: 4061, 2009. 247. Pohl A, Zhang W, Yang D, Lurje G, Ning Y, Khambata-Ford S, Langer C, Kahn M, Teo JL, Lenz HJ. Association of CD133 polymorphisms and clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) treated with either first-line 5-FU + bevacizumab (BV) or second-line irinotecan (IR)/cetuximab (CB) or IR alone. Poster Session. Proc ASCO 27: 4062, 2009. 248. Singh H, Pohl A, El-Khoueiry A, Lurje G, Zhang W, Yang D, Ning Y, Shriki J, Iqbal S, Lenz H. Use of genetic variants to predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). Poster Session. Proc ASCO 27: 4070, 2009. 249. Leichman L, Goldman BH, Benedetti JK, Billingsley KG, Thomas CR, Iqbal S, Lenz H, Blanke C, Gold PJ, Corless CL. Oxaliplatin (OXP) plus protracted infusion 5- fluorouracil (PIFU) and external beam radiation (EBRT) prior to surgery (S) for potentially curable esophageal adenocarcinoma (EA): A Southwest Oncology Group (SWOG) phase II trial with molecular correlates (S0356). Poster Discussion. Proc ASCO 27: 4513, 2009. 250. Chhibar RS, Yang D, Zhang W, Lurje G, Pohl A, Ning Y, El-Khoueiry A, Iqbal S, Lenz HJ. Effect of gender and age on overall survival in patients with esophageal cancer. Poster Session. Proc ASCO 27: 4541, 2009. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 120 of 173

251. Lurje G, Leers JM, Pohl A, Oezcelik A, Zhang W, Yang D, Hagen JA, DeMeester SR, DeMeester TR, Lenz HJ. Polymorphisms in epidermal growth factor (EGF) and proteinase activated receptor 1 (PAR-1) associated with tumor recurrence in localized adenocarcinoma (EA) of the esophagus treated with surgery alone. Poster Session. Proc ASCO 27: 4564, 2009. 252. Lara P, Chansky K, Shibata T, Fukuda H, Tamura T, Saijo N, Redman M, Lenz HJ, Natale R, Gandara DR. Cisplatin + irinotecan versus cisplatin + etoposide in extensive stage small cell lung cancer (E-SCLC): Final "common arm": Comparative outcomes analysis of JCOG 9511 and SWOG 0124. Poster Discussion. Proc ASCO 27: 8027, 2009. 253. Zhang W, Dahlberg SE, Yang D, Sandler AB, Brahmer JR, Schiller JH, Carbone DP, Johnson DH, Lenz H. Genetic variants in angiogenesis pathway associated with clinical outcome in NSCLC patients (pts) treated with bevacizumab in combination with carboplatin and paclitaxel: Subset pharmacogenetic analysis of ECOG 4599. Poster Discussion. Proc ASCO 27: 8032, 2009. 254. Iqbal S, Yang D, Cole S, El-Khoueiry AB, Boswell W, Agafitei R, Lujan R, Lenz HJ. Phase II study of capecitabine and gemcitabine in patients with metastatic colorectal cancer (mCRC). Proc ASCO 27: e15077, 2009. 255. Hendifar AE, Yang D, Iqbal S, Lenz H, El-Khoueiry A. Gender disparities in hepatocellular cancer survival. Proc ASCO 27: e15517, 2009. 256. Ottochian M, Yang D, El-Khoueiry A, Iqbal S, Pohl A, Zhang W, Ning Y, Lenz HJ. Association of gender, age, and ethnicity with survival in patients with. pancreas cancer. Proc ASCO 27: e15587, 2009. 257. Virk N, Yang D, Lenz HJ, El-Khoueiry AB, Danenberg KD, Iqbal S. Molecular profiling in patients (pts) with upper gastrointestinal (UGI) cancers correlated with clinical outcome. Proc ASCO 27: e22042, 2009. 258. Holmes RS, Rankin C, Makar KW, Benedetti JK, Smalley SR, Blanke CD, Lenz HJ, Ulrich CM. Polymorphisms in folate-metabolizing enzymes and response to 5- fluorouracil amount stage II or III rectal cancer patients. INT-0144 SWOG 9304, ASTRO 2009. 259. Lenz HJ. Pharmacogenomics in colon cancer. European Journal of Cancer. 7(4); SP150, 2009. 260. Ricker C, Ault G, El-Khoueiry A, Iqbal S, Spicer D, Lenz HJ. Familial Adenomatous Polyposis (FAP) in 9 Hispanic Women Characteristics of Lynch Syndrome in 13 Hispanic Families. The Collaborative Group of the Americas on Inherited Colorectal Cancer – 13th Annual CGA-ICC Meeting. Poster Session. Honolulu, Hawaii. 10/17- 18/2009. 261. Winder T, Zhang W, Yang D, Ning Y, Bohanes PO, Pohl A, Lurje G, Lenz H. Association of germline polymorphism in the CD44 gene with clinical outcome in localized astric adenocarcinoma. Proc ASCO 27: 2, 2009. 262. Philip PA, Goldman BH, Ramanathan RK, Lenz H, Lowy AM, Whitehead RP, Iqbal S, Chung VM, Benedetti JK, Blanke C. Phase I trial of combination gemcitabine, erlotinib (NSC-718784), and IMC-A12 (NSC-742460 as first-line treatment in patients with metastatic pancreatic cancer: Southwest Oncology Group study S727. Proc ASCO 27: 233, 2009. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 121 of 173

263. Thomas CR, Goldman BH, Benedetti JK, Lenz H, Beeker T, Abbruzzese JL, Blanke C. Cetuximab plus cisplatin, irinotecan, and thoracic radiotherpy (TRT) as definitive treatment for locally advanced, unresectable esophageal cancer (EC): A SWOG (S0414) phase II trial. Proc ASCO 27: 72, 2009. 264. Raghavan D, Tangen CM, Moinpour C, Gotay C, Albain KS, Louie S, Lenz HJ, Quinn DI, Hussain M, Thompson I. Paclitaxel-gemcitabine (P-G) for patients (pts) with advanced urothelial cancer (UC), aged > 70 years (yrs): SWOG 0028. Poster Session, 2010. 265. O’Donnell R, El-Khoueiry AB, Lenz H, Gandara DR. A phase I trial of escalating doses of the anti-igf-1R monoclonal antibody (mAb) cixutumumab (IMC-A12) and sorafenib for treatment of advanced hepatocellular carcinoma (HCC). Proc ASCO 28: TPS212, 2010. 266. Philip PA, Goldman BH, Ramanathan RK, Lenz H, Lowy AM, Whitehead RP, Iqbal S, Chung VM, Benedetti JK, Blanke CD. SWOG SO727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line tratment in patients (pts) with metastatic pancreatic cancer. Proc ASCO 28: TPS223, 2010. 267. LaBonte MJ, Yang D, Zhang W, Wilson PM, Ladner RD, Winder T, Bohanes PO, Ning Y, Lenz H. Correlation of cyclin D1, A870G, polymorphism, and clinical outcome in patients with HER2-positive, metastatic breast cancer treated with lapatimib plus capecitabine. Proc ASCO 28: 1015, 2010. 268. Iqbal S, El-Khoueiry AB, Yang D, Cole S, Boswell W, Shriki J, Ning Y, Agafitei RD, Menendez X, Lenz H. A phase I study of celecoxib (C) and patupilone (EP09006) in patients (pts), with metastatic colorectal cancer (mCRC). Proc ASCO 28: 2533, 2010. 269. El-Khoueiry AB, Iqbal S, Lenz H, Roman L, Gitlitz BJ, Yang D, Cole S, Shriki J, Hughlett C, Garcia A. A phase I study of two different schedules of nab-paclitaxel (Nab-p) with ascending doses of vandetanib (V) inpatients (pts) with advanced solid tumors. Proc ASCO 28: 3059, 2010. 270. Sawyer MB, Iqbal S, Lenz H, Rocha Lima CS, Rossignol DP, Krivelevich I, Fan J, El- Khoueiry AB. Phase II study of E782 in combination with cetuximab in subjects (pts) with metastatic and refractory colorectal Cancer (CRC). Proc ASCO 28: 3537, 2010. 271. Lenz H, Zhang W, Yang D, El-Khoueiry AB, Ning Y, Pohl A, Bohanes PO, Danenberg KD, Winder T. Association of GRP78 Polymorphisms with response and TTP in patients with mCRC treated with FOLFOX/BV. Proc ASCO 28: 3590, 2010. 272. Shibata S, Longmate J, Chung VM, Lenz H, Kummar S, Sarantopoulos J, Harrison ML, Synold TW, Ivy SP, Newman EM. A phase I and pharmacokinetic single agent study of pazopanib (P) in patients (Pts) with advanced malignancies and varying degrees of liver dysfunction (LD). Proc ASCO 28: 2571, 2010. 273. Kummar S, Chen AP, Ji JJ, Allen D, Egorin MJ, Gandara DR, Lenz H, Morgan R, Newman EM, Doroshow JH. A phase I study of ABT-888(A) in combination with metronomic cyclophosphamide (C) in adults with refractory solid tumors and lymphomas. Proc ASCO 28: 2605, 2010. 274. Winder T, Zhang W, Yang D, Ning Y, Bohanes PO, Hu-Lieskovan S, Mauro DJ, Langer C, Rowinsky EK, Lenz H.Use of germ-line polymorphisms in genes involved in the IGF pathway to predict efficacy of cetuximab independent of K-ras in mcRC patients (IMCL-0144). Proc ASCO 28: 3562, 2010. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 122 of 173

275. Vallbohmer D, Grimminger PP, Yang D, Danenberg KD, Danenberg P, Arnold D, Machiels JH, Roedel C, Velenik V, Lenz H. Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in advanced rectal cancer. Proc ASCO 28: 3563, 2010. 276. Ladner RD, Ulrich CM Rankin CJ, Danenberg KD, Danenberg PV, Smalley SR, Makar KW, Benedetti JK, Blanke CD, Lenz H. Association of intratumoral gene expression levels of thymidine phosphorylase (TP) and VERF with clinical outcome in stage II/III rectal cancer patients treated with 5-fluorouracil and pelvic radiation in a phase III intergruop tiral (SWOG 9304). Proc ASCO 28: 3640, 2010. 277. Hu-Lieskovan S, Yang D, Grimminger PP, Arnold D, Dellas K, Machiels JH, Roedel C, Velenik V, Lenz H, Vallbohmer D. Use of EGF a+61G and TS-5;URT 2R/3R polymorphisms to predict complete pathologic response in locally advanced rectal cancer patients undergoing preoperative cetuximab-based chemoradiation followed by surgery. Proc ASCO 28: 3641, 2010. 278. Leichman, LP, Goldman B, Thomas CR, Billingsley KG, Corless CL, Lenz H, Iqbal S, Benedetti JK, Gold PJ, Blanke CD. An Updated Report on the Rathologic Complete Response and Survival Outcome of Southwest Oncology Group (SWOG S0536): A Phase II Trial of Oxaliplatin (oxp) Plus Protracted Infusion 5-Fluorouracil (PIFU) and Extranal Beam Radiation (EBRT) Prior to Surgery(s) for Potentially Curable Esophageal Adenocarcinoma (EA) with Molecular Correlates. J Radiation Oncol 78(3):61, 2010. 279. Lenz HJ, Zhang W, Gladkov O, Chao Y, Urba S, Kemner AM, Kaneko, T, Franklin N, Yang D, Moon H. Lapatinib + capecitabine in advanced gastric cancer: an open-label, phase 2 study. ESMO Poster Session, LPT109747 abstract. Milan, Italy. 10/ 9/ 2010. 280. Giamas G, Filipovic A, Jocob J, Shifa BA, Green AR, Ellis IO, Lenz H-J, Stebbing J. Kinome screening for regulators of estrogen receptor identifies a novel kinase as a new therapeutic target in breast cancer. CTRC-AACR S3-7. Cancer Res; 70(24 Suppl.) 12/15/2010. 281. Bohanes PO, Goldman BH, Benedetti J, Blanke CD, Leichman LP, Iqbal S, Thomas Jr. CR, Corless CL, Gold PJ, Lenz HJ. Association of expression (GE) with outcome in stage II-III esophageal adenocarcinoma (EA) patients treated with preoperative platinum-based chemoradiation (CRT) in a phase II cooperative study (SWOG) 0356. ASCO GI poster session. San Francisco, CA. 1/20-22/11. 282. Pishvaian M, Sakaeva D, Hsieh RK, Rha SY, Caderillo-Ruiz G, Miller Jr. WH, Kemner AM, Nagarwala YM, Zhang W, Lenz H. A global, multicenterphase II trial of lapatinib plus capecitabine in gastric cancer. ASCO GI poster session. San Francisco, CA. 1/20- 22/11. 283. Mulcahy MF, Small Jr. W, Talamonti M, Obel JC, Rocha Lima CS, Safran H, Lenz HJ, Chiorean EG, Link CJ. Effect of the addition of algenpantucel-L immunotherapy to standard adjuvant therapy on survival in patients with resected pancreas cancer. ASCO GI poster session. San Francisco, CA. 1/20-22/11. 284. Zhang W, Labonte MJ, Yang D, Ning Y, Gerger A, Bohanes PO, Winder T, El- Khoueiry AB, Iqbal S, Lenz HJ. Use of genetic variants in formyl peptide receptor 2 (FPR2 to predict tumor recurrence in stage II colon cancer. ASCO GI poster session. San Francisco, CA. 1/20-22/11. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 123 of 173

285. Gerger A, Bohanes PO, Yang D, Winder T, Ning Y, Labonte MJ, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ. Human epidermal growth factor receptor-2 (HER2) Iie665Val single nucleotide plymorphism (SNP) is associated with gender-specific outcome in patients with metastatic colorectal cancer (mCRC)treated with cetuximab in a phase II study (IMCL-0144. ASCO GI poster session. San Francisco, CA. 1/20-22/11. 286. Hardacre J, Mulcahy M, Talamonti M, Obel J, Rocha Lima C, Safran H, Lenz HJ, Chiorean E, Vahanian N, Link CJ. Addition of algenpantucel-L immunotherapy to standard adjuvant therapy may improve survival and disease free survival (DFS) in resected pancreas cancer patients. ASCO GI poster session: A85, 2011. 287. Ning Y, LaBonte MJ, Zhang W, Bohanes P, Gerger A, Yang D, Lenz HJ. CXCR2 antagonist represses tumor cell metastasis and angiogenesis and is synergistic with oxalilplatin in colorectal cancer cell line and xenograft models. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2- 6; Orlando, Florida. Philadelphia (PA): AACR;Abstract #2586. 288. Newman Em, Morgan RJ, Beumer JH, Blanchard SM, El-Khoueiry AB, Kummar S, Carroll MI, Synold TW, Lenz HJ, Doroshow JH. Phase I and pharmacokinetic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2’deoxycytidine: A California Cancer Consortium Study. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Florida. Philadelphia (PA): AACR;Abstract #1283. 289. Winder T, Giamas G, Zhang W, Yang D, Bohanes PO, Ning Y, Gerger A, Labonte MJ, Stebbing J, Lenz H. Use of insulin-like growth factor (IGF) pathway polymorphism IGF1R_rs2016347 to predict tumor recurrence in estrogen receptor–positive breast cancer patients. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #538. 290. Ning Y, Zhang W, Yang D, Weber D, Souami F, Bohanes PO, Gerger A, Labonte MJ, Benhaim L, Lenz H. Analysis of polymorphisms in sodium channel, voltage-gated, type I, alpha subunit (SCN1A) as predictors of clinical outcome and toxicity in advanced ovarian cancer patients enrolled in a phase III trial treated with patupilone. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #5051. 291. El-Khoueiry AB, Iqbal S, Lenz HJ, Gitlitz BJ, Yang D, Cole S, Duddalwar V, Garcia A. A phase I study of two different schedules of nab-paclitaxel (nab-P) with ascending doses of vandetanib (V) with expansion in patients (Pts) with pancreatic cancer (PC). In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #4124. 292. Zurita AJ, Heymach J, Khajavi M, Tye L, Huang X, Kulke M, Lenz H, Meropol NJ, Carley W, DePrimo SE, Harmon CS. Circulating protein and cellular biomarkers of sunitinib in patients with advanced neuroendocrine tumors. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #4079. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 124 of 173

293. Iqbal S, Labonte MJ, Yang D, Zhang W, Bohanes PO, Ning Y, Benhaim L, El- Khoueiry R, Wilson PM, Gerger A, El-Khoueiry AB, Lenz H. Polymorphisms in EGF a+61G, GSTP1 Ile105Val, and MTHFR A1298C to predict response and survival in a phase II study for patients with metastatic or unresectable gastric (G) or gastroesophageal junction (GEJ) cancer treated with capecitabine, oxaliplatin (XELOX), and cetuximab. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract #4121. 294. Labonte MJ, Yang D, Zhang W, Wilson PM, Gerger A, Bohanes PO, Ning Y, Benhaim L, El-Khoueiry R, Nagarwala YM, Kemner AM, Pishvaian MJ, Hsieh RK, Gladkov O, Urba S, Rha SY, Sakaeva D, Iqbal S, El-Khoueiry AB, Lenz H. Use of MTHFR A1298C polymorphism to predict response in a phase II international clinical trial of patients with advanced gastric (GC) or gastroesophageal junction (GEJ) adenocarcinoma treated with first-line lapatinib plus capecitabine. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract # 4076. 295. Bohanes PO, Goldman BH, Leichman LP, Blanke CD, Iqbal S, Thomas CR, Corless CL, Billingsley KG, Danenberg KD, Zhang W, Benedetti JK, Gold PJ, Lenz H. Association of excision repair cross-complementation group 1 (ERCC1) gene expression (GE) with outcome in stage II-III esophageal adenocarcinoma (EA) patients treated with preoperative platinum-based chemoradiation (CRT) in a phase II cooperative group study (SWOG S0356). In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract # 4023. 296. Lenz H, Ning Y, Zhang W, Yang D, Cole S, Agafitei RD, Menendez X, Cheng P, Iqbal S, El-Khoueiry AB. Association of single-nucleotide polymorphisms (SNPs) in sodium channel, voltage-gated, type I, alpha subunit (SCN1A) with toxicity in metastatic colorectal cancer (mCRC) patients (pts) in a phase I study of patupilone (EPO906) and celebrex (C). In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO; Abstract # e14039. 297. Zhang W, Yang D, Harbison C, Khambata-Ford S, Malone DP, Ning Y, Bohanes PO, Gerger A, Labonte MJ, Benhaim L, El-Khoueiry AB, Iqbal S, Lenz H. FCGR2A H131R and FCGR3A V158F polymorphism status in mCRC patients treated with single-agent cetuximab (IMCL 0144 and CA225045) or with second-line irinotecan plus cetuximab (EPIC): A pooled statistical analysis. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO;Abstract #e14025. 298. Yang D, Benhaim L, Zhang W, Bohanes PO, Ning Y, Gerger A, Labonte MJ, Groshen SG, El-Khoueiry AB, Iqbal S, Lenz H. Gender and cause-specific survival in patients with stage III colon cancer: A SEER study. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO; Abstract #e14006. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 125 of 173

299. Benhaim L, Gerger A, Zhang W, Yang D, Bohanes PO, Ning Y, Winder T, Labonte MJ, Wilson PM, El-Khoueiry R, El-Khoueiry AB, Iqbal S, Lenz H. Cancer stem cell gene variants associated with colon cancer recurrence. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #3612. 300. Ladner RD, Zhang W, Labonte MJ, Yang D, Ning Y, Gerger A, Bohanes PO, Winder T, El-Khoueiry AB, Iqbal S, Petasis N, Lenz H. Prediction of tumor recurrence in stage II colon cancer through genetic variants in formyl peptide receptor 2 (FPR2). In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session;Abstract #3604. 301. Gerger A, Zhang W, Yang D, Bohanes PO, Ning Y, Winder T, Labonte MJ, Wilson PM, Benhaim L, El-Khoueiry R, Absenger G, El-Khoueiry AB, Iqbal S, Lenz H. Angiogenesis gene polymorphisms and clinical outcome of metastatic colorectal cancer treated with first-line bevacizumab and oxaliplatin-based chemotherapy. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract #3592. 302. Lin EH, Lenz H, Saleh MN, Badarinath S, Knost JA, MacKenzie MJ, Polite BN, Kavan P, Chen EX, Leichman LP, Pathiraja K, Lu KB; A fixed-sequence, open-label study to determine the activity of SCH 717454 (robatumumab) as assessed by positron emission tomography in patients with relapsed or recurrent colorectal cancer. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract #3584. 303. Wilson PM, Bohanes PO, Rankin CJ, Benedetti JK, Ulrich CM, Smalley SR, Makar KW, Zhang W, Winder T, Ning Y, Gerger A, Benhaim L, El-Khoueiry R, Labonte MJ, Blanke CD, Lenz H. The final results of the SWOG S9304 phase III intergroup trial’s pharmacogenetic analysis: Association of polymorphisms with survival and toxicity in stage II/III rectal cancer patients treated with 5-fluorouracil (5-FU) and pelvic radiation (RT). In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract #3542. 304. Sarantopoulos J, Lenz H, LoRusso P, Shibata S, Kummar S, Mulkerin D, Ramanathan RK, Mita MM, O'Rourke P, Remick SC, Goel S, Gutierrez M, Ramalingam SS, Murgo A, Davies AM, Mani S, Boni J, Shapiro M, Ivy SP, Takimoto CH. Phase I pharmacokinetic study of temsirolimus (CCI-779) in patients with advanced malignancies and normal and impaired liver function: An NCI Organ Dysfunction Working Group (ODWG) study. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO poster session; Abstract #3072. 305. Saif MW, Lichinitser M, Gordon MS, Tan BR, Scheulen ME, Pandya NB, Sarantopoulos J, Rinehart JJ, Verschraegen CF, Lenz H, Zergebel C, Saito K. A phase I study evaluating the pharmacokinetics of components of S-1 in pts with varying degrees of renal function. In: Proceedings of the 47th Annual Meeting of the American Society of Clinical Oncology; 2011 June 3-7; Chicago, Illinois: ASCO; Abstract #e13089. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 126 of 173

306. Kwak EL, Shapiro GI, Cohen SM, Becerra CR, Lenz HJ, Gooden S, Robohn M, Le- Maulf F, Chand VK, Lafrate AJ. A Phase II trial of afatinib (BIBW 2992) in patients with tumours prospectively creened for EGFR and/or HER2 gene amplification or EGFR-activating mutations. In: Proceedings of the 2011 European Multidisciplinary Cancer Congress; 2011 Sept 26; Stockholm, Sweden: ECCO/ESMO Poster Session 1.417. 307. Grothey A, Sobrero AF, Siena S, Falcone Ychou M, Lenz HJ, Yoshino T, Cihon F, Wagner A, Van Cutsem E. Results of a phase III randomized, double-blind, placebo- controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies. 2012 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Abstract # LBA385. 308. Philip PA, Goldman BH, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Iqbal S, Gaur R, Benedetti JK, Blanke CD. Phase I randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib as first-line treatment in patients with metastatic pancreatic cancer (SWOG-0727). 2012 Gastrointestinal Cancers Symposium Poster Session B;Jan 19-21; San Francisco, CA; Abstract #198. 309. Wakatsuki T, Bohanes PO, Zhang W, Gerger A, Yang D, Ning Y, Winder T, Labonte MJ, Wilson P, Benhaim L, El-Khoueiry AB, Iqbal S, Giamas G, Stebbing J, Lenz HJ. Use of genetic variants of LMTK3 to predict tumor recurrence in female localized gastric adenocarcinoma. 2012 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Abstract #63. 310. Labonte MJ, Goldman BH, Zhang W, Blanke CD, Philip PA, Wong R, O'Reilly EM, Benedetti JK, Lenz HJ. Use of EGF A61G polymorphism to predict overall survival in a phase III study of gemcitabine plus cetuximab versus gemcitabine in patients with locally advanced or metastatic pancreatic adenocarcinoma (SWOG 0205). 2012 Gastrointestinal Cancers Symposium Poster Session B;Jan 19-21;San Francisco; Abstract #203. 311. Loupakis F, Zhang W, Gerger A, Yang D, Bohanes PO, Labonte MJ, Benhaim L, Wakatsuki T, Ning Y, Wilson P, El-Khoueiry R, El-Khoueiry AB, Iqbal S, Barzi A, Giamas G, Stebbing J, Lenz HJ. LMTK3 polymorphism in patients with metastatic colon cancer. 2012 Gastrointestinal Cancers Symposium Poster Session C;Jan 19-21; San Franscisco, CA; Abstract #471. 312. Zhang W, Gerger A, Labonte MJ, Yang D, Bohanes PO, Ning Y, Winder T, Wilson P, Benhaim L, El-Khoueiry R, El-Khoueiry AB, Iqbal S, Giamas G, Stebbing J, Lenz HJ. Association of gender-related tumor recurrence with a polymorphic variant of LMTK3 in stage II and III colon cancer. 2012 Gastrointestinal Cancers Symposium Poster Session C;Jan 19-21; San Francisco, CA; Abstract #454. 313. Hobday TJ, Qin R, Reidy DL, Moore MJ, Strosberg JR, Kaubisch A, Shah MH, Kindler HL, Lenz HJ, Chen HX, Erlichman C. Multicenter phase II trial of temsirolimus (TEM) and bevacizumab (BEV) in pancreatic neuroendocrine tumor (PNET). 2012 Gastrointestinal Cancers Symposium Poster Session B;Jan 19-21; San Francsico, CA; Abstract #260. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 127 of 173

314. Giamas G, Zhang H, Zhang W, Filipovic A, Lenz HJ, Stebbing J. Identification of noval kinases involved in Estrogen receptor-a (Era) signalling and the development of endocrine resistance in breast cancer. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 March 31 – April 4; Chicago, IL: AACR;Abstract #64. 315. Zhang H, Paez D, Giamas G, Filipovic A, Yang D, Bohanes P, Ning Y, Gerger A, Labonte MJ, Stebbing J, Lenz HJ. Genetic variants in human epidermal growth factor receptor (HER) family gene predict tumor recurrence in breast cancer. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 March 31 – April 4; Chicago, IL: AACR poster session;Abstract #2670. 316. Skinner E, Goldman B, Sakr W, Petrylak P, Lenz H, Lee CT, Wilson SS, Lerner SP, Tangen CM, Thompson IM. SWOG S0353: Phase II trial of inductionplus 1 year monthly maintenance intravesicle gemcitabine for paitens with recurrence following 2 prior courses of BCG. American Urological Association Annual Meeting;May 19-23, 2012. 317. Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Wagner A, Laurent D, Grothey A. Phase III CORRECT trial of regorafenib in metastatic colorectal cancer (mCRC). In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract #3502. 318. Sarantopoulos J, Hoering A, Synold TW, Mahalingam D, Wang D, Lenz HJ, O'Rourke P, Sexton R, Van Veldhuizen PJ, Mita MM, Wong L, Mita AC, El-Khoueiry AB, Chung VM, Gandara DR, Tejwani S, Takebe N, Takimoto CHM, Ivy SP, Kurzrock R. Phase I pharmacokinetic study of dasatinib (BMS-354825) in patients with advanced malignancies and varying levels of liver dysfunction: S0711, a SWOG early therapeutics committee study. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster Session; Abstract #3078. 319. El-Khoueiry AB, Rankin CJ, Iqbal S, Micetich KC, Kayaleh O, Lenz HJ, Blanke CD. SWOG 0941: A phase II study of sorafenib and erlotinib in patients (pts) with advanced gallbladder cancer or cholangiocarcinoma. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4049. 320. Philip PA, Goldman BH, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Iqbal S, Gaur R, Benedetti JK, Blanke CD. Dual blockade of epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor-1 (IGF-1R) signaling in metastatic pancreatic cancer: Phase I/randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG-0727). In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4019. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 128 of 173

321. Catenacci DVT, Bahary N, Edelman MJ, Nattam SR, de Wilton Marsh R, Kaubisch A, Wallace JA, Cohen DJ, Stiff PJ, Sleckman BG, Thomas SP, Lenz HJ, Henderson L, Zagaya C, Vannier M, Karrison T, Stadler WM, Kindler HL. A phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): Interim analysis of a University of Chicago phase II consortium study. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4022. 322. Hardacre JM, Mulcahy MF, Small W, Talamonti MS, Obel JC, Rocha Lima CMS, Safran H, Lenz HJ, Chiorean EG, Vahanian NN, Link CJ. Addition of algenpantucel-L immunotherapy to standard of care (SOC) adjuvant therapy for pancreatic cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4049. 323. Hobday TJ, Qin R, Reidy DL, Moore MJ, Strosberg JR, Kaubisch A, Shah MH, Kindler HL, Lenz HJ, Chen H, Erlichman C. Multicenter phase II trial of temsirolimus (TEM) and bevacizumab (BEV) in pancreatic neuroendocrine tumor (PNET): Results of a planned interim efficacy analysis. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4047. 324. Genyk Y, Matsuoka L, El-Khoueiry AB, Iqbal S, Buxbaum J, Selby R, Vandam J, Lenz HJ. R0 resection of locally advanced pancreatic cancer encasing major visceral arteries using arterial reconstruction: Short- and long-term results. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract #e14679. 325. Gordon MA, Gundacker H, Benedetti J, Macdonald JS, Baranda JC, Levin WJ, Blanke CD, Elatre W, Weng P, Lenz HJ, Press MF. Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT- 0116/SWOG9008 clinical trial. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4010. 326. Wakatsuki T, Zhang W, Yang D, Loupakis F, Azuma M, Gerger A, Graziano F, Ning Y, Labonte MJ, El-Khoueiry R, Bohanes PO, Benhaim L, Páez D, Watanabe M, Koizumi W, Lenz HJ. Ethnic gene profile of genes involved in angiogenesis to predict regional bevacizumab efficacy difference in gastric cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4026. 327. Cremolini C, Loupakis F, Yang D, Salvatore L, Zhang W, Wakatsuki T, Schirripa M, Lonardi S, Antoniotti C, Aprile G, Masi G, Graziano F, Ruzzo A, Lucchesi S, Ronzoni M, Maus MKH, Bocci G, Tonini G, Falcone A, Lenz HJ. Prospective evaluation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer (mCRC) patients (pts) treated with first-line FOLFIRI plus bevacizumab (BV). In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #3518. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 129 of 173

328. Iqbal S, El-Khoueiry AB, Yang D, Páez D, Duddalwar V, Zhang W, Agafitei RD, Lujan R, Cole S, Ning Y, El-Khoueiry R, Loupakis F, Wakatsuki T, Lenz HJ. A phase II study of capecitabine-oxaliplatin and cetuximab in patients (pts) with advanced/metastatic gastric cancer (G) or gastroesophageal junction (GEJ) adenocarcinoma. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4096. 329. Barzi A, Wakatsuki T, Zhang W, Yang D, Loupakis F, Ning Y, El-Khoueiry R, Labonte MJ, Azuma M, Bohanes PO, Benhaim PO, Gerger A, Koizumi W, Watanabe M, Stebbing J, Giamas G, Lenz HJ. Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC). In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract #4088. 330. Zhang W, Benhaim L, Yang D, Gerger A, Bohanes PO, Páez D, Loupakis F, Wakatsuki T, Labonte MJ, Ning Y, El-Khoueiry R, Zhang H, Stebbing J, Giamas G, Lenz HJ. Genetic variants of kinases suppressors of ras (KSR1) to predict survival in patients with ER-alpha positive metastatic breast cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract #e11018. 331. Páez D, Labonte MJ, Paré L, Yang D, Bohanes PO, Gerger A, Zhang W, Benhaim L, Ning Y, Wakatsuki T, Loupakis F, Lenz HJ. Use of leucine-rich and immunoglobulin- like domains germ-line polymorphisms to predict clinical outcome in metastatic colorectal cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract #e14052. 332. Ning Y, Winder T, Zhang W, Yang D, Loupakis F, Wakatsuki T, Bohanes PO, EI- Khoueiry R, Barzi A, Iqbal S, EI-Khoueiry AB, Lenz HJ. Association of genetic variants in plastin family genes with tumor recurrence in stage II/III colon cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract # e14031. 333. Wilson P, Páez D, Gerger A, Zhang W,Yang D, Labonte MJ, Benhaim L, Bohanes PO, Ning Y,Wakatsuki T, Loupakis F, Lenz HJ. Use of germ-line variants in the WNT/β- CATENIN pathway to predict tumor recurrence in adjuvant colon cancer. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO; Abstract # e14034. 334. Loupakis F, Yang D, Zhang W, Cremolini C, Wakatsuki T, Salvatore L, Antoniotti C, Aprile G, Schirripa M, Ricci V, Lucchesi S, Masi G, Maus MKH, Lonardi S, Ning Y, El-Khoueiry R, Falcone A, Lenz HJ. Primary side of origin affects the outcome of mCRC patients treated with first-line FOLFIRI plus bevacizumab independently of BRAF status and mucinous histology. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract # 3549. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 130 of 173

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342. Benhaim L, Loupakis F, Zhang W, Gerger A, Bohanes PO, Páez D, Cremolini C, Wakatsuki T, Yang D, Ning Y, El-Khoueiry R, Zhang H, Salvatore L, Schirripa M, Falcone A, Giamas G, Stebbing J, Lenz HJ. Genetic variants of kinases suppressors of ras in KRAS-BRAF wild-type metastatic colorectal cancer patients treated with cetuximab and irinotecan. In: Proceedings of the 48th Annual Meeting of the American Society of Clinical Oncology; 2012 June 1 - 5; Chicago, Illinois: ASCO poster session; Abstract # 3597. 343. Sobrero A, Grothey A, Van Cutsem E, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Ternero J, Yoshino T, Lenz HJ, Goldberg R, Sargent D, Cihon F Jeffers M, Wagner A, Laurent D. Phase 3 CORRECT trial of regorafenib in metastatic colorectal cancer (MCRC). In: Proceeedings of the International Symposium: 14th World Congress on GI Cancer. 2012 June 27-30; Barcelona, Spian: ESMO oral session; Annuals of Oncology 23;(4).Abstract# 0 -0023. 344. Cremolini C, Loupakis F, Yang D, Salvatore L, Zhang W, Wakatsuky T, Schirripa M, Lonardi S, Antoniotti C, Aprile G, Masi G, Graziano F, Ruzzo A, Lucchesi S, Maus M Bocci G, Falcone A, Lenz HJ. In: Proceeedings of the International Symposium: 14th World Congress on GI Cancer. 2012 June 27-30; Barcelona, Spain: ESMO poster session; Annuals of Oncology 23;(4).Abstract# P-0262. 345. Antoniotti C, Loupakis F, Cremolini C, Zhang W, Yang D, Wakatsuky T, Schirripa M, Salvatore L, Ricci V, Graziano F, Masi G, Labonte MJ, Ning Y, Falcone A, Lenz HJ. Prospective study of EGFR Intron 1 CA Tandem repeats as predictive factor of benefit from cetuximab and irinotecan. In: Proceeedings of the International Symposium: 14th World Congress on GI Cancer. 2012 June 27-30; Barcelona, Spain: ESMO poster session; Annuals of Oncology 23;(4).Abstract# P-0263. 346. Loupakis F, Yang D, Feng S, Cremolini C, Zhang W, Antoniotti C, Langer C, Hurwitz H, Saltz L, Falcone A, Lenz HJ. Premary Tumor location is a major independent prognostic factor for MCRC patients. In: Proceeedings of the International Symposium: 14th World Congress on GI Cancer. 2012 June 27-30; Barcelona, Spain: ESMO poster discussions; Annuals of Oncology 23;(4).Abstract# PD-0009. 347. Schirripa M, Loupakis F, Cremolini C, Dongyun Y, Labonte MJ, Zhang W, Salvatore L, Wakatsuky T, Antoniotti C, Aprile G, Lucchesi S, Giamas G, Stebbing J, Falcone A, Lenz HJ. KSR1 gele polymorphism in MCRC patients treated with first-line and bevacizumab. In: Proceedings of the International Symposium: 14th World Congress on GI Cancer. 2012 June 27-30; Barcelona, Spain: ESMO poster discussions; Annuals of Oncology 23;(4).Abstract# PD-0015. 348. Yoshino T, Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Lenz HJ, Cihon F, Wagner W, Grothey A. Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies. 2012 July 26-28; Osaka, Japan: Plenary Session Discussant; The 10th Annual Meeting of JSMO; Abstract# PLS-4. 349. Lenz HJ. Personalized Treatment Options for Patients with Colorectal Cancer. In: Proceedings of the 40th ISOBM Congress. 2012October 13-17; Jerusalem, Israel: Oral session. Tumor Biol;33(Suppl 1):S15-S80,O13.4. Abstract#289. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 132 of 173

350. Benhaim L, Gerger A, Bohanes PO, Paez D, Wakatsuki T, Yang D, Labonte MJ, Wu z, Ning Y, Loupakis F, El-Khoueiry R, Laurent-Puig P, Lenz H-J. Gender specific profiling in SCN1A polymorphisms and time to recurrence in patients with stage II/III colorectal cancer. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19- 21; San Francisco, CA; Suppl 34;Abstract #393. 351. Starodub A, Thomas SP, Lee F, Harish V, Koh HA, Mitchell EP, Mandanas RA, Huh SY, Badarinath S, Mittan A, Leon L, Vogt T, Langer C, Lenz HJ. Biomarker distribution and characteristics for the first 100 patients in MAVERICC, a randomized phase II study of mFOLFOX6-bevacizumab (BV) versus FOLFIRI-BV in previously untreated metastatic colorectal cancer (mCRC). 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #483. 352. Jeffers M, Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent D, Cihon F, Wagner A, Laurent D, Grothey A. Mutational analysis of biomarker samples from the CORRECT study: Correlating mutation status with clinical response to regorafenib. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #381. 353. Wakatsuki T, Paez D, Labonte MJ, Yang D, Azuma M, Ning Y, Volz N, Stintzing S, Bohanes PO, El-Khoueiry R, Koizumi W, Watanabe M, Lenz HJ. Association between genetic variations involved in tumor dormancy related genes and clinical outcomes in Japanese patients with gastric cancer. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #43. 354. Barzi A, Shabihkhani M, Yu S, Yang D, Ji L, Lenz HJ. Racial disparities and the outcome of metastatic (met) colorectal cancer (CRC). 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #373. 355. Genyk Y, Barzi A, El-Khoueiry AB, Matsuoka L, Sutton V, Buxbaum J, Iqbal S, Van Dam J, Selby R, Lenz HJ. The feasibility of R0 resection of locally advanced pancreatic cancer (LAPC) encasing major visceral arteries (T4 lesions) using arterial resection and reconstruction: Short- and long-term outcomes. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #243. 356. Grothey A, Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Wagner A Laurent D, Cupit L. Time course of regorafenib-associated adverse events in the phase III CORRECT study. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #467. 357. Maus MKH, Stephens C, Astrow AH, Grimminger PP, Yang D, Loupakis F, Hsiang J, Zeger G, Huang X, Lenz HJ. Correlation of messenger RNA expression patterns of ERCC1, TS, EGFR, and VEGFR2 with KRAS and BRAF mutational status in advanced colorectal cancer: Implications for targeted therapies. 2013 Gastrointestinal Cancers Symposium Poster Session A;Jan 19-21; San Francisco, CA; Suppl 34;Abstract #383. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 133 of 173

358. Yang D, Usher J, LoCoco J, Pritesh C, Lenz HJ, El-Khoueiry AB. Impact of gender on survival of patients (pts) with hepatocellular carcinoma (HCC): SEER analysis. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 - June 4; Chicago, Illinois: ASCO poster session; Abstract # 4128. 359. Shabihkhani M, Yu S, Yang D, Lenz HJ, Barzi A. Hispanic race and outcome of metastatic (MET) colorectal cancer (CRC): Biology or health care (HC) setting? In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO poster session; Abstract # e17559. 360. El-Khoueiry AB, Ning Y, Yang D, Cole S, Kahn M, Zoghbi M, Berg J, Fujmori M, Inada T, Kouji H, Lenz HJ. A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO oral session; Abstract # 2501. 361. Zhang W, Ning Y, Yang D, Wakatsuki T, Stintzing S, Volz NB, Li JE, Labonte MJ, El- Khoueiry RE, Barzi A, El-Khoueiry AB, Kahn M, Lenz HJ. Prediction of tumor recurrence by tumor location in stage II and III colon cancer patients through common germ-line variants of genes involved in wnt signaling pathway. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e14714. 362. Ladner RD, Kahn M, Stintzing S, Zhang W, Wakatsuki T, Ning Y, Volz NB, Labonte MJ, Wilson PMD, Kardosh A, Lenz HJ. Risk of tumor-related death in stage I-II colon based on gender and tumor location. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e14538. 363. Bokemeyer C, Kohne C, Bondarenko I, Heydebreck A, Grote HJ, Stroh C, Lenz HJ. Treatment outcome according to tumor ERCC1 expression status in OPUS study patients with metastatic colorectal cancer (mCRC) randomized to FOLFOX4 with/without cetuximab. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3537. 364. Schultheis AM,Volz NB, Zhang W, Yang D, Ning Y, Stintzing S,Wakatsuki T, El- Khoueiry RE, Li JE, Kardosh A, Barzi A, El-Khoueiry AB, Lenz HJ. Use of genetic variants in immune response genes to predict clinical outcome in mCRC patients treated with cetuximab-based therapy. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3567. 365. Semrad TJ, Lenz HJ, Gong I-Y, Tanaka MS, Eddings C, Mahaffey N, Mack PC, Beckett L, Lara P. Pharmacodynamic separation (PDS) of gemcitabine (Gem) and the epidermal growth factor receptor (EGFR) inhibitor erlotinib (E) in patients (Pts) with advanced pancreatic cancer: Phase II results. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e15073. 366. Barzi A, Directo M, Dasu S, Lenz HJ, Sadeghi S. Saving lives and costs through screening (Sc) for colorectal cancer (CRC): Implications for limited-resource healthcare systems (LRHS). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 6545. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 134 of 173

367. Luu TH, Frankel PH, Lim D, Cristea MC, Beumer JH, Appleman LJ, Lenz HJ, Gandara DR, Piekarz R, Newman EM. Phi-53: (NCI#7251): Phase I trial of belinostat (PXD101) in combination with 13-cis-retinoic acid (13c-RA) in advanced solid tumor malignancies—A California Cancer Consortium NCI/CTEP sponsored trial. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 2526. 368. Li JE, Zhang W, Loupakis F, Yang D, Wakatsuki T, Ning Y, Stintzing S, El-Khoueiry RE, Volz NB, Marmorino F, Schirripa M, Salvatore L, Antoniotti C, Cremolini C, Lenz HJ. EGFL7 polymorphism to predict tumor response in metastatic colorectal cancer (mCRC) patients (pts) treated with FOLFIRI and bevacizumab (BV). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3565. 369. Stintzing S, Zhang W, Wakatsuki T, Ning Y, Volz NB, Li JE, Labonte MJ, Wilson P, Kardosh A, Loupakis F, Salvatore L, Schirripa M, Lenz HJ. Genes involved in EGFR- degradation to predict for efficacy in metastatic colorectal cancer patients treated with cetuximab. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3557. 370. Naughton MJ, Schrag D, Venook AP, Niedzwiecki D, Anderson RT, Lenz HJ, Grubbs SS. Quality of life (QOL) and toxicity among patients in CALGB 80405. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3611. 371. Volz NB, Zhang W, Yang D, Ning Y, Stintzing S, Wakatsuki T, El-Khoueiry RE, Li JE, Kardosh A, Loupakis F, Marmorino F, Antoniotti C, Lenz HJ. Use of genetic variants in pericyte-driven tumor vessel maturation genes to predict treatment efficacy in mCRC patients treated with FOLFIRI/bevacizumab. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3566. 372. Ning Y, Zhang W, Yang D, Loupakis F, Wakatsuki T, Stintzing S, Volz NB, Li JE, El- Khoueiry RE, Labonte MJ, Cremolini C, Marmorino F, Barzi A, El-Khoueiry AB, Lenz HJ, Kahn M. Use of genetic variants in wnt signaling pathway to predict gender and tumor location dependent survival in metastatic colorectal cancer (mCRC) patients (pts) treated with first-line FOLFIRI and bevacizumab (BEV). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3568. 373. Hanna DL, Maus MKH, Stephens C, Grimminger PP, Astrow SH, Yang D, Loupakis F, Hsiang J, Zeger G, Barzi A, Lenz HJ. Correlation of ERCC1 mRNA expression with KRAS mutation status in colorectal, pancreatic, and lung adenocarcinoma. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 11062. 374. Koczywas M, Lenz HJ, Mortimer JE, El-Khoueiry AB, Frankel PH, Gandara DR, Cristea MC, Chung VM, Lim D, Reckamp DL, Lau DHM,Ye W, Doyle AL, Carroll MI, Newman EM. PHI-55: (NCI#7427): A phase I study of halichondrin B analog (E7389) in combination with cisplatin (CDDP) in advanced solid tumors: A CCC, NCI/CTEP-sponsored trial (grant U01 CA 062505). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 2564. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 135 of 173

375. Rossi GR, Hardacre JH, Mulcahy MF, Talamonti MS, Obel JC, Rocha Lima CMS, Safran H, Lenz HJ, Chiorean EG,Vahanian NN, Link CJ. Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody (Ab) titers and correlation with improved overall survival. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3007. 376. Wilson P, Wakatsuki T, Loupakis F, Zhang W, Yang D, Stintzing S, Ning Y, Volz NB, El-Khoueiry RE, Li JE, Labonte MJ, Sunakawa Y, Maus MKH, Ladner RD, Barzi A, Iqbal S, El-Khoueiry AB, Lenz HJ. Association of a polymorphism in amphiregulin with worse prognosis in metastatic colorectal cancer patients treated with cetuximab. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e14543. 377. Maus MKH, Hanna DL, Stephens C, Grimminger PP, Epstein M, Astrow SH, Yang D, Loupakis F, Hsiang J, Zeger G, Wakatsuki T, Barzi A, Lenz HJ. Gene expression profiles and tumor locations in colorectal cancer (left vs. right vs. rectum). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3527. 378. Hobday TJ, Qin R, Moore MJ, Reidy DL, Strosberg JR, Kindler HL, Shah MH, Lenz HJ, Kaubisch A, Chen HX, Erlichman C. Multicenter phase II trial of temsirolimus (TEM) and bevacizumab (BEV) in pancreatic neuroendocrine tumor (PNET). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 4032. 379. Hochster HS, Messersmith WA, O'Neil BH, Groshen SG, Lenz HJ, Cohen DJ, Denlinger CS, Gold PJ, Eckhardt SG, Locker GY, Ames P, McKinley M, Leichman LP. The MEK inhibitor selumetinib ([SEL], AZD6244, ARRY-142886) plus irinotecan (IRI) as second-line therapy for KRAS-mutated (KRASm) metastatic colorectal cancer (CRC). In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3587. 380. Iqbal S, Wakatsuki T, Bohanes PO, Zhang W, Gerger A, Azuma M, Stotz M, Yang D, Ning Y, Volz NB, Stintzing S, El-Khoueiry RE, Labonte MJ, Li JE, Maus MKH, Koizumi W, Watanabe M, Barzi A, Lenz HJ, El-Khoueiry AB. Iiteglinα4 (ITGα4) rs7562325 polymorphism was associated with better survivals in Austrian but not in Japanese patients with gastric cancer. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e15009. 381. Wakatsuki T, Zhang W, Yang D, Azuma M, Ning Y, Volz NB, Stintzing S, El- Khoueiry RE, Li JE, Wilson P, Labonte MJ, Maus MKH, Sunakawa Y, Koizumi W, Watanabe M, Iqbal S, Barzi A, El-Khoueiry AB, Shah MA, Lenz HJ. Association of AREG exon 1 polymorphism with worse prognosis in Japanese and U.S. patients with gastric cancer. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # e15022. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 136 of 173

382. El-Khoueiry RE, Wakatsuki T, Ning Y, Zhang W, Yang D, Azuma M, Gerger A, Stotz M, Labonte MJ, Wilson P, Volz NB, Stintzing S, Maus MKH, Sunakawa Y, Koizumi W, Watanabe M, Li JE, Barzi A, El-Khoueiry AB, Lenz HJ. Association of transcription factor 7-like 2 (TCF7L2) polymorphisms with worse survival in three independent cohorts from the United States, Austria, and Japan in patients with gastric cancer. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 4111. 383. Labonte MJ, Wakatsuki T, Zhang W, Yang D, Azuma M, Gerger A, Stotz M, Ning Y, Volz NB, Stintzing S, Li JE, El-Khoueiry RE, Wilson P, Koizumi W, Watanabe M, Maus MKH, Barzi A, Iqbal S, El-Khoueiry AB, Lenz HJ. Prognostic outcome of gastric cancer patients with cancer stem cell SNPs in Asian versus western countries. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 4110. 384. Catenacci DVT, Bahary N, Nattam SR, De Wilton Marsh R, Wallace JA, Rajdev L, Cohen DJ, Sleckman BJ, Lenz HJ, Stiff PJ, Thomas SP, Xu P, Henderson L, Horiba MN, Vannier M, Karrison T, Stadler WM, Kindler HL. Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago phase II consortium study. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 4012. 385. Lenz HJ, Van Cutsem E, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Goldberg RM, Sargent DJ, Cihon F, Wagner A, Laurent D, Jeffers M, Grothey A. Analysis of plasma protein biomarkers from the CORRECT phase III study of regorafenib for metastatic colorectal cancer. . In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3514. 386. Van Cutsem E, Sobrero A, Siena S, Falcone A,Ychou M, Humblet Y, Bouche O, Mineur Barone L,C , Adenis A, Argilés G, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Wagner A, Laurent D, Cupit L, Grothey A. Regorafenib (REG) in progressive metastatic colorectal cancer (mCRC): Analysis of age subgroups in the phase III CORRECT trial. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3636. 387. Grothey A, Sobrero AF, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Argiles G, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Wagner A, Cupit L, Laurent D, Van Cutsem E. Time profile of adverse events (AEs) from regorafenib (REG) treatment for metastatic colorectal cancer (mCRC) in the phase III CORRECT study. In: Proceedings of the 49th Annual Meeting of the American Society of Clinical Oncology; 2013 May 31 – June 4; Chicago, Illinois: ASCO Abstract # 3637. 388. Prager G, Schuler A, Ay C, Pausz C, Lenz HJ, Pabinger I, Zielinski C. Integrin genetic variants and risk of thromboembolic events in patients with colorectal cancer. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # 462. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 137 of 173

389. Ciardiello F, Lenz HJ, Kohne CH, Heinemann V, Tejpar , Esser R, Beier F, Stroh C, Duecker K, Van Cutsem E. Effect of KRAS and NRAS mutational status on first-line treatment with FOLFIRI plus cetuximab in patients with metastatic colorectal cancer (mCRC): New results from the CRYSTAL trial. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # LBA443. 390. Stremitzer S, Berghoff AS, Volz NB, Zhang W, Yang D, Stintzing S, Ning Y, Sunakawa Y, Shinichi Y, Sebio A, El-Khoueiry RE, Bimer P, Preusser M, Lenz HJ. Influence of genetic variants of genes potentially associated with colorectal brain metastases on overall survival. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # 487. 391. Barzi A, Stern MC, Zhang J, Lenz HJ, Iqbal S, Liu L. Gastric Cancer (GC) in California Cancer Registry (CCR): One disease, many faces. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # 30. 392. Sunakawa Y, Wakatuki T, Zhang W, Yang D, Azuma M, Ning Y, Stintzing S, Stremitzer S, Yamauchi S, Sebio A, Volz NB, El-Khoueiry R, Koizumi W, Watanabe M, Lenz HJ. Use of genetic variants in c-MET to predict clinical outcome in localized gastric cancer (GC) patients (pts) treated with surgery. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # 50. 393. El-Khoueiry AB, O’Donnell R, Mack PC, Blanchard S, Bahary N, Jiang Y, Yen Y, Wright JJ, Chen H, Lenz HJ, Gandara DR. A phase I trial of cixutumumab (C) (IMC- A12) and sorafenib (S) for treatment of advanced hepatocellular carcinoma (HCC). 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # 293. 394. Tejpar S, Lenz HJ, Kohne CH, Heinemann V, Ciardiello F, Esser R, Beier F, Stroh C, Duecker K, Bokemeyer C. Effect of KRAS and NRAS mutations on treatment outcomes in patients with metastatic colorectal cancer (mCRC) treatment first-line with cetuximab plus FOLFOX4: New results from the OPUS study. 2014 Gastrointestinal Cancers Symposium Poster Session A;Jan 16-18; San Francisco, CA; Suppl 3;Abstract # LBA444. 395. Berlin J, Ramanathan R, Strickler JH, Subramaniam DS, Hurwitz H, Kang YK, Kim TY, Shepherd SP, Xiong H, Hetman R, Nickner C, Dudley MW, Giranda VL, Lenz HJ. A phase 1 dose-escalation study of veliparib with bimonthly FOLFIRI in patients with advanced solid tumors. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 2574. 396. Rossi GR, Rocha Lima CMS, Hardacre JM, Mulcahy MF, Talamonti MS, Obel JC, Safran H, Lenz HJ, Chiorean EG, Vahanian NN, Link CJ. Correlation of anti- calreticulin antibody titers with improved overall survival in a phase 2 clinical trial of algenpantucel-L immunotherapy for patients with resected pancreatic cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3029. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 138 of 173

397. Larson G, Stephens C, Astrow SH, Jack Hsiang, Lenz HJ. KRAS screening for clinically important mutants via a multiplex allele-specific PCR assay for exons 2, 3, and 4. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14569. 398. Stintzing S, Stremitzer S, Heinemann V, Jung A, Sunakawa Y, Matsusaka S, Yamauchi S, Zhang W, Yang D, Ning Y, Sebio A, Hanna DL, Siamak S, Lenz HJ. Amphiregulin (AREG) SNP rs161511 to predict cetuximab efficacy independent of AREG mRNA levels: Data from FIRE3 (AIO KRK-0306). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3521. 399. Yang D, Stremitzer S, Zhang W, Ning Y, Stintzing S, Sebio A, Sunakawa Y, Yamauchi S, Matsusaka S, El-Khoueiry RE, Stift J, Wrba F, Gruenberger T, Lenz HJ. Association of outcome with genes involved in tumor dormancy in patients with resected colorectal liver metastases. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14512. 400. Yamauchi S, Loupakis F, Matsusaka S, Zhang W, Yang D, Ning Y, Stintzing S, Sunakawa Y, Stremitzer S, Sebio A, El-Khoueiry RE, Pasquini G, Marmorino F, Schirripa M, Fujimoto Y, Ueno M, Mizunuma N, Lenz HJ. Association of single nucleotide polymorphisms in genes involved in autophagy with overall survival in patients with metastatic colorectal cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14506. 401. Stremitzer S, Zhang W, Yang D, Ning Y, Stintzing S, Sebio A, Sunakawa Y, Yamauchi S, Matsusaka S, El-Khoueiry RE, Stift J, Wrba F, Gruenberger T, Lenz HJ. Association outcome with genes involved in immune response and checkpoints in patients with resected colorectal liver metastases. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3563. 402. Stintzing S, Stremitzer S, Heinemann V, Falcone A, Loupakis F, Cremolini C, Antoniotti C, Sunakawa Y, Matsusaka S, Yamauchi S, Zhang W, Yang D, Ning Y, Sebio A, Hanna DL, Siamak S, Lenz HJ. Biomarker validation study: Genes involved in ubiquitin proteasome system (UPS) dependent EGFR-degradation for prediction of efficacy in metastatic colorectal cancer patients treated with cetuximab. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3571. 403. Renfro LA, Loupakis F, Adams RA, Seymour MT, Schmoll HJ, Douillard JY, Hurwitz H, Fuchs CS, Diaz-Rubio E, Porschen R, Tournigand C, Falcone A, Tebbutt MC, Hecht JR, Punt CJA, Goldberg RM, Saltz L, De Gramont A, Sargent DJ, Lenz HJ. Body mass index (BMI) as prognostic in metastatic colorectal cancer (mCRC): A pooled analysis of 21 first-line trials in the ARCAD database. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3537. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 139 of 173

404. Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Mahoney MR, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Mayer RJ, Schilsky RL, Bertagnolli MM, Blanke CD. CALGB/SWOG 80405: Phase III trial of irinotecan/5- FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # LBA3. 405. Siamak S, Sunakawa Y, Loupakis F, Yang D, Zhang W, Ning Y, Stintzing S, Stremitzer S, Sebio A, Yamauchi S, Matsusaka S, El-Khoueiry RE, Rossini CAD, Cremolini C, Falcone A, Lenz HJ. CCL2 polymorphism as a predictive marker for bevacizumab (Bev) in combination with FOLFIRI as first-line treatment in metastatic colorectal cancer (mCRC) patients (pts). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14556. 406. Hanna DL, Garcia AS, Zhang W, Yang D, Loupakis F, Stintzing S, Stremitzer S, Ning Y, Sunakawa Y,Yamauchi S, Matsusaka S, Cremolini C, El-Khoueiry RE, Falcone A, Lenz HJ. Common genetic variants in genes involved in the Hippo pathway: Novel biomarkers in metastatic colorectal cancer patients treated with irinotecan plus cetuximab. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14523. 407. Garcia AS, Marmorino F, Gerger A, Zhang W,Yang D, Ning Y, Stintzing S, Stremitzer S, Sunakawa Y,Yamauchi S, Matsusaka S, Salvatore L, Cremolini C, El-Khoueiry RE, Falcone A, Lenz HJ. Genetic variant in the down syndrome candidate region 1 (DSCR1) gene: A novel biomarker in metastatic colorectal cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14544. 408. Ning Y, Zhang W,Yang D, Stintzing S, Sunakawa S, Stremitzer S, Sebio A,Yamauchi S,Matsusaka S, Zoratto F, Loupakis F, El-Khoueiry RE, Barzi A, El-Khoueiry AB, Kahn M, Lenz HJ. Genetic variants of CBP and SOX9 to predict clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) treated with first-line FOLFIRI and bevacizumab (FOLFIRI/BEV). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14528. 409. Ning Y, Stintzing S, Heinemann V, Zhang W,Yang D, Sunakawa Y, Stremitzer S, Sebio A,Yamauchi S, Matsusaka S, El-Khoueiry R, Barzi A, El-Khoueiry AB, Lenz HJ. Genetic variants of TCF7L2 and AXIN2 predict gender and tumor location- dependent clinical outcome in FIRE-3 trial: A validation study. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3602. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 140 of 173

410. Garcia AS, Zhang W, Yang D, Stremitzer S, Stintzing S, Ning Y, Sunakawa Y, Yamauchi S, Matsusaka S, El-Khoueiry RE, Barzi A, Iqbal S, El-Khoueiry AB, Lenz HJ. Germline polymorphisms in genes involved in the Hippo pathway to predict recurrence in locally advanced colon cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e14505. 411. Zhang W, Schumacher F, Loupakis F, Van Den Berg D, Cremolini C, Stintzing S, Ning N, Sebio A, Stremitzer S, Sunakawa Y, Matsusaka S, Yamauchi S, El-Khoueiry R, Falcone A, Lenz HJ. High-throughput exome array for identification of novel polymorphisms associated with clinical outcome in mCRC patients treated with first- line FOLFOXIRI/BEV versus FOLFIRI/BEV (TRIBE trial; NCT00719797). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3632. 412. Preusser M, Stremitzer S, Berghoff AS,Volz NB, Zhang W, Yang D, Stintzing S, Ning Y, Sunakawa Y,Yamauchi S, Sebio A, Matsusaka S, El-Khoueiry RE, Birner P, Lenz HJ. Influence of genetic variants of genes potentially associated with brain metastases on overall survival in 70 colorectal cancer patients. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3565. 413. Stremitzer S, Zhang W, Yang D, Ning Y, Stintzing S, Sebio A, Sunakawa Y,Yamauchi S, Matsusaka S, El-Khoueiry RE, Stift J, Wrba F, Gruenberger T, Lenz HJ. Influence of genetic variations of the angiopoietin and pericyte pathways in resected colorectal liver metastases. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3564. 414. Gerger A, Herzog S, Szkandera J, Pichler M, Stotz M, Schaberl-Moser R, Samonigg H, Lax S, Leitner G, Renner W, Berghold A, Lenz HJ. LGR5 rs17109924 to predict chemoresistance to 5FU-based chemotherapy in adjuvant colon cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3580. 415. Yang D, Loupakis F, Cremolini C, Antoniotti C, Schirripa M, Salvatore L, Moran M, Astrow SH, Falcone A, Lenz HJ. mRNA expression levels of candidate genes and clinical outcome in mCRC patients treated with FOLFOXIRI plus bevacizumab (bev) or FOLFIRI plus bev in the TRIBE study. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3640. 416. Ciardiello F, Lenz HJ, Kohne CH, Heinemann V, Tejpar S, Melezinek I, Beier F, Stroh C,Van Cutsem E. Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3506. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 141 of 173

417. Bokemeyer C, Kohne CH, Ciardiello F, Lenz HJ, Heinemann V, Klinkhardt U, Beier F, Duecker K,Tejpar S. Treatment outcome according to tumor RAS mutation status in OPUS study patients with metastatic colorectal cancer (mCRC) randomized to FOLFOX4 with/without cetuximab. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 3505. 418. Sunakawa Y, Zhang W, Yang D, Wakatsuki T, Ning Y, Stintzing S, Stremitzer S, Sebio A,Yamauchi S, Matsusaka S, El-Khoueiry RE, Iqbal S, Barzi A, Azuma M, Watanabe M, Koizumi W, Lenz HJ. Association of polymorphisms in the CCL2/CCR2 axis with clinical outcome in localized advanced gastric cancer (AGC) patients (pts) from the United States and Japan. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 4052. 419. Barzi A, Stern MC, Zhang J, Deapen D, Lenz HJ, Liu L. Gastric cancer (GC) among California Asians: Analysis of California Cancer Registry (CCR). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 4086. 420. Sunakawa Y, Volz NB, Zhang W, Yang D, Wakatsuki T, Ning Y, Stintzing S, Stremitzer S, Sebio A, Yamauchi S, Matsusaka S, El-Khoueiry RE, Iqbal S, Barzi A, Azuma M,Watanabe M, Koizumi W, Lenz HJ. Genetic variants in tumor immune checkpoints as prognostic markers in patients (pts) with localized advanced gastric cancer (AGC). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 4018. 421. El-Khoueiry AB, O'Donnell R, Mack PC, Blanchard S, Bahary N, Jiang Y, Wright JJ, Chen HX, Lenz HJ, Gandara DR. A phase I trial of of cixutumumab (C) (IMC-A12) and sorafenib (S) for treatment of advanced hepatocellular carcinoma (HCC). In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # 4105. 422. Matsusaka S, Loupakis F, Zhang W, Yang D, Ning Y, Stintzing S, Sunakawa Y, Yamauchi S, Stremitzer S, Sebio A, El-Khoueiry RE, Pasquini G, Marmorino F, Schirripa M, Inoshita N, Ishikawa Y, Ueno M, Mizunuma N, Lenz HJ. Association of the prognostic role of CXCR4/CXCL12 polymorphism with treatment outcomes after bevacizumab-based chemotherapy in metastatic colorectal cancer. In: Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology; 2014 May 30 – June 3; Chicago, Illinois: ASCO Abstract # e22008. 423. Lenz H, Niedzwiecki D, Innocenti F, Blanke C, Mahony M, O’neil b, Shaw J, Polite B Hochster H, Atkins J, Goldberg R, Mayer R, Schilsky R, Bertagnolli M, Venook A. CALGB/SWOG 80405: PHASE III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colonor rectum (MCRC). 38th ESMO Congress 2014 September 26-30; Madrid, Spain: Abstract # 8058. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 142 of 173

424. Venook A, Niedzwiecki D, Lenz H, Mohoney M, Innocenti F, O’Neil B, Hochster H, Goldberg R, Schilsky R, Mayer R, Polite B, Atkins J, Shaw J, Bertagnolli M, Blanke C. CALGB/SWOG 80405: Analysis of patients undergoing surgery as part of treatment strategy. 38th ESMO Congress 2014 September 26-30; Madrid, Spain: Abstract # LBA10. 425. Van Cutsem E, Tabernero J, Yoshino T, Sassi M, Oum’Hamed Z, Studeny M, Lenz HJ. LUME – Colon 1: double–blind, randomised Phase III study of nintedanib plus best supportive care (BSC) versus placebo plus BSC in patients with refractory colorectal cancer. 38th ESMO Congress 2014 September 26-30; Madrid, Spain: Poster session: Abstract # 610Tip. 426. Tabernero J, Van Geel R, Bendell JC, Spreaflico A, Schuler M, Yoshino T, Delord JP, Yamada Y, Lolkema MP, Faris JE, Eskens F A.L.M, Sharma S, Yaeger R, Lenz HJ, Wainberg ZA, Avsar E, Chatterjee A, Jaeger S, Demuth T, Schellens J H.M. Phase I study of the selective BRAF v600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the a-specific P13K inhibitor alpelisib (BYL719) in patients with advanced BRAF mutant colorectal cancer. Plenary Session 8 on “Targeting RAS and Other Driver Oncogenes”. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 2014 November 18-21: Barcelona, Spain: Abstract. 427. Lenz HJ, Tabernero J, Yoshino T, Oum'Hamed Z, Vlassak S, Sassi M, Van Cutsem E. LUME-Colon 1: A double-blind, randomized phase III study of nintedanib plus best supportive care (BSC) versus placebo plus BSC in patients with colorectal cancer (CRC) refractory to standard therapies. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #TPS794. 428. Lenz HJ, Van Cutsem E, Verma UN, Saltzman M, Fuloria J, Khojasteh A, Wiesenfeld M, Cihon F, Wagner A, Grothey A. Subgroup analysis of patients enrolled in the United States in the CORRECT phase 3 trial of the multikinase inhibitor regorafenib (REG) in metastatic colorectal cancer (mCRC). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #767. 429. Larson G, Israyelyan A, Lenz HJ, Astrow SH. Expanded KRAS and NRAS assays increase detection of mutations that predict for resistance to therapy in colorectal cancer patients. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #519. 430. Kidd MT, Wilcox E, Rogers J, Eng C, Saadat S, Lenz HJ, Hubbard JM, Grothey A. Efficacy of chemotherapy after treatment with regorafenib in metastatic colorectal cancer (mCRC). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15- 17; San Francisco, CA; Suppl 3; Abstract #678. 431. Yamauchi S, Okazaki S, Barzi A, Zhang W, Yang D, Cao S, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, El-Khoueiry R, Mendez A, Parekh A, Lenz HJ. Association between single nucleotide polymorphisms (SNPs) of genes involved in spindle assembly checkpoint (SAC) and clinical outcomes in advanced gastric cancer (AGC) patients (pts) treated with taxane-based chemotherapy. 2015 Gastrointestinal Cancers Symposium Poster Session A;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #79. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 143 of 173

432. Matsusaka S, Loupakis F, Zhang W, Cao S, Yang D, Ning Y, Stremitzer S, Sunakawa Y, Yamauchi S, El-Khoueiry R, Parekh A, Mizunuma N, Lenz HJ. Polymorphism of the chemokine CXCR4 to predict treatment benefit of first-line bevacizumab-based chemotherapy in patients with metastatic colorectal cancer. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #635. 433. Stremitzer S, Stintzing S, Heinemann V, Zhang W, Yang D, Ning Y, Sunakawa Y, Sebio A, Yamauchi S, Matsusaka S, Parekh A, Mendez A, El-Khoueiry, Lenz HJ. Variations in Y chromosome-related genes and clinical outcome in metastatic colorectal cancer. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15- 17; San Francisco, CA; Suppl 3; Abstract #634. 434. Sunakawa Y, Ichikawa W, Tsuji A, Moran M, Astrow SH, Yang D, Zhang W, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Takeuchi M, Lenz HJ, Fujii M, Nakajima T. EGFR ligands and ERCC1 mRNA expression to predict clinical outcome in Japanese (JPN) patients (pts) with metastatic colorectal cancer (mCRC) harboring overexpressed EGFR and KRAS exon 2 wild-type (KRAS wt) treated with cetuximab (cet) plus oxaliplatin-based chemotherapy (JACCRO CC-05/06 AR). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #618. 435. Sunakawa Y, Stintzing S, Heinemann V, Loupakis F, Cremolini C, Cao S, Yang D, Zhang W, Parekh A, Yamauchi S, Ning Y, Stremitzer S, Matsusaka S, Mendez A, El- Khoueiry RE, Lenz HJ. Macrophage polarization related gene variants to predict clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) treated with bevacizumab (bev) in combination with FOLFIRI. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #621. 436. Ng K, Venook AP, Sato K, Hollis BW, Niedzwiecki D, Ye C, Chang I-W, O'Neil BH, Innocenti F, Lenz HJ, Blanke CD, Mayer RJ, Fuchs CS, Meyerhardt JA. Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #507. 437. Kopetz S, McDonough S, Morris VK, Lenz HJ, Magliocco AM, Atreya CE, Diaz LA, Allegra CJ, Lieu CH, Eckhardt SG, Semrad TJ, Kaberle K, Guthrie K, Hochster HS. S1406: Randomized phase II study of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (mCRC). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #TPS790. 438. Grothey A, Falcone A, Humblet Y, Bouche O, Mineur L, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Xu L, Wagner A, Van Cutsem E. Subgroup analysis of patients with metastatic colorectal cancer (mCRC) treated with regorafenib (REG) in the CORRECT trial who had progression-free survival (PFS) longer than 4 months. 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #710. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 144 of 173

439. Ichikawa W, Sunakawa Y, Tsuji A, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Tanioka H, Negoro Y, Takagane A, Tani S, Yamaguchi T, Masuishi T, Takeuchi M, Lenz HJ. Association of EGFR CA simple sequence repeat 1 (CA-SSR1) variant with cetuximab (cet)-induced skin toxicity (ST) in Japanese metastatic colorectal cancer (mCRC) patients (pts) with overexpressed EGFR and KRAS exon 2 wild-type (KRASwt) (JACCRO CC-05/06 AR). 2015 Gastrointestinal Cancers Symposium Poster Session C;Jan 15-17; San Francisco, CA; Suppl 3; Abstract #582. 440. Ferencz TR, Hochster H, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Komatsu Y, Sobrero A, Peeters M, Van Cutsem E, Zaniboni A, Tran B, Wahba M, Atalla G, Lenz HJ, Ohtsu A, Mayer RJ. Efficacy and safety from RECOURSE: a multicenter, randomized, double-blind, phase 3 study of TAS-102 versus placebo with best supportive care in patients with metastatic colorectal cancer refractory to standard therapies. 2015 ACCP Global Conference on Clinical Pharmacy. Oct 17-21; Abstract #35743. 441. Schellens JHM, Van Geel R, Bendell JC, Spreafico A, Schuler M, Yoshino T, Delord JP, Yamada Y, Lolkema MP, Faris JE, Eskens FALM, Sharma S, Yaeger R, Lenz HJ, Wainberg ZA, Avsar E, Chatterjee A, Jaeger S, Demuth T, Tabernero, J. Final biomarker analysis of the phase I study of the selective BRAF V600 inhibitor encorafenib (LGX818) combined with cetuximab with or without the α-specific PI3K inhibitor alpelisib (BYL719) in patients with advanced BRAF-mutant colorectal cancer. . In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 April 18 – 22; Philadelphia, PA: AACR;Abstract Presentation #CT136. Lenz HJ, Schumacher F, Loupakis F, Cremolini C, Ning Y, Stremitzer S, Sunakawa Y, Matsusaka S, Okazaki S, Zhang W, Falcone A. Effect of genetic variation on overall survival in a clinical trial of metastatic colorectal cancer (mCRC). In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract #3562. 442. Lenz HJ, Tabernero J, Yoshino T, Oum'Hamed Z, Vlassak S, Sassi M, Cutsem EV. LUME-Colon 1: A double-blind, randomized phase III study of nintedanib plus best supportive care (BSC) versus placebo plus BSC in patients with colorectal cancer (CRC) refractory to standard therapies. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract #TPS3625. 443. Barzi A, Lenz HJ, Quinn DI, Sadeghi S. Colonoscopy versus less invasive approaches for colorectal cancer (CRC) screening (Scr): A strategic perspective. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract #6523. 444. Cleary JM, Mayer RJ, Cutsem EV, Yamashita F, Yoshisue K, Ieiri I, Ohtsu A, Lenz HJ. Population pharmacokinetic (PK) analysis of TAS-102 in patients (pts) with metastatic colorectal cancer (mCRC): Results from 3 phase 1 trials and the phase 3 RECOURSE trial. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 2579. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 145 of 173

445. Graver S, Stremitzer S, Sunakawa Y, Edelmann W, Kockx M, Schartl M, Scherer SJ, Lenz HJ, Mazzone M. Immune response triggered by a novel molecular crosstalk of major hallmarks of cancer: Angiogenesis, mismatch repair, and immune pathways. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 11054. 446. Matsusaka S, Wu AH, Cao S, Mizunuma N, Chin K, Zhang W, Yang D, Ning Y, Stremitzer S, Sunakawa Y, Okazaki S, Parekh A, El-Khoueiry RE, Mendez A, Lenz HJ. Prognostic impact of Forkhead box-F1 (FOXF1) polymorphisms on the clinical outcome in gastric cancer patients. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 4039. 447. Okazaki S, Stintzing S, Heinemann V, Cao S, Zhang W, Yang D, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, Elkhoueiry R, Mendez A, Parekh A, Lenz HJ. TLR6 polymorphism associated with overall survival in metastatic colorectal cancer (mCRC) patients treated with FOLFIRI/bevacizumab enrolled in FIRE3. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 11039. 448. Sunakawa Y, Stintzing S, Heinemann V, Cremolini C, Falcone A, Cao S, Yang D, Zhang W, Yamauchi S, Ning Y, Stremitzer S, Matsusaka S, Parekh A, Graver S, Mendez A, Okazaki S, El-Khoueiry R, Scherer SJ, Loupakis F, Lenz HJ. Variations in genes regulating tumor-associated macrophages (TAMs) to predict outcome of bevacizumab (bev)-based treatment in patients with metastatic colorectal cancer (mCRC): Results from TRIBE and FIRE3 trials. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3552. 449. McWilliams RR, Ko AH, Chiorean EG, Kwak EL, Lenz HJ, Nadler PI, Wood DL, Fujimori M, Morita K, Inada T, Kouji H. A phase Ib dose-escalation study of PRI-724, a CBP/beta-catenin modulator, plus gemcitabine (GEM) in patients with advanced pancreatic adenocarcinoma (APC) as second-line therapy after FOLFIRINOX or FOLFOX. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # e15270. 450. Kim GP, Van Cutsem E, Lenz HJ, Verma UN, Saltzman M, Fuloria J, Khojasteh A, Wiesenfeld M, Cihon F, Wagner A, Grothey A. Subgroup analysis of patients enrolled in the United States in the CORRECT phase 3 trial of the multikinase inhibitor regorafenib (REG) in metastatic colorectal cancer (mCRC). : Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # e14649. 451. Leichman CG, McDonough SL, Smalley SS, Billingsley KG, Lenz HJ, Beldner MA, Hezel AF, Velasco MR, Guthrie KA, Blanke CD, Hochster HS. S0713: A phase II study of cetuximab (CET) added to induction chemotherapy (ICT) of oxaliplatin (OX) and capecitabine (CAP), followed by neoadjuvant chemoradiation (NACR) for locally advanced rectal cancer (LARC). In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3516. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 146 of 173

452. Parekh A, Ning Y, Stintzing S, Loupakis F, Zhang W, Yang D, Sunakawa Y, Stremitzer S, Matsusaka S, Okazaki S, Elkhoueiry R, Mendez A, Barzi A, Schirripa M, Heinemann V, Lenz HJ. Genetic variant of TWEAK to predict clinical outcome in mCRC patients (pts) treated with first line FOLFIRI and Bevacizumab (FOLFIRI/BEV) in FIRE-3 and TRIBE cohorts. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3554. 453. Ning Y, Zhang W, Hanna DL, Mendez A, Yang D, Sunakawa Y, Stremitzer S, Matsusaka S, Okazaki S, Parekh A, El-Khoueiry RE, Flores B, Hauch S, Barzi A, El- Khoueiry AB, Lenz HJ. Circulating tumor cell (CTC) EMT and stem cell biomarker expression predict overall survival (OS) in mCRC by a combined immunomagnetic qRT-PCR approach. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 11018. 454. Zhang W, Curtis C, Stintzing S, Heinemann V, Parekh A, Yang D, Cao S, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, Okazaki S, El-Khoueiry RE, Mendez A, Barzi A, El-Khoueiry AB, Lenz HJ. Profiling of differentially expressed genes in right and left side mCRC patients using nCounter customized gene expression assay. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # e14586. 455. Teufel M, Schwenke S, Seidel H, Beckmann G, Reischl J, Vonk R, Lenz HJ, Tabernero J, Siena S, Grothey A, Cutsem EV, Jeffers M, Wilhelm S, Wagner A, Laurent D, Kobina S, Rutstein MD, Wirapati P, Guinney J, Tejpar S. Molecular subtypes and outcomes in regorafenib-treated patients with metastatic colorectal cancer (mCRC) enrolled in the CORRECT trial. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3558. 456. Ng K, Venook AP, Sato K, Yuan C, Hollis BW, Niedzwiecki D, Ye C, Chang IW, O'Neil BH, Innocenti F, Lenz HJ, Blanke CD, Mayer RJ, Fuchs CS, Meyerhardt JA. Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance). In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3503. 457. Benhaim L, Zhang W, Wakatsuki T, Gerger A, Yang D, Paez D, Ning Y, El-Khoueiry RE, Loupakis F, Bohanes PO, Stintzing S, Heinemann V, Lenz HJ. Genetic variants of kinases suppressors of Ras (KSR) to predict tumor response to first-line cetuximab in patients with mCRC: Prospective analysis in the FIRE 3 trial. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology; 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3613. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 147 of 173

458. Parekh A, Sunakawa Y, Cao S, Matsusaka S, Yang D, Zhang W, Wakatsuki T, Ning Y, Stremitzer S, Mendez A, Okazaki S, Elkhoueiry R, Iqbal S, Barzi A, Azuma M, Watanabe M, Koizumi W, Wu AH, Lenz HJ. Estrogen receptor beta (ERβ) gene polymorphisms as a predictor of overall survival in patients with gastric cancer (GC) from Japan and Los Angeles County (LAC). In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology. 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 4036. 459. Innocenti F, Owzar K, Jiang C, Sibley A, Niedzwiecki D, Lenz HJ, Bertagnolli MM, Friedman PN, Furukawa Y, Kubo M, Ratain MJ, Blanke CD, Venook AP, McLeod HL. A genome-wide association study (GWAS) of overall survival (OS) in 609 metastatic colorectal cancer (mCRC) patients treated with chemotherapy and biologics in CALGB 80405. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology. 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 3599. 460. Becerra C, Stephenson J, Jonker DJ, Cohn AL, Asmis TR, Bekaii-Saab TS, Conkling PR, Garbo LE, Lenz HJ, Richards DA, Spira AI, Mikhail S, Goodwin RA, Yoon HH, Hume S, Hitron M, Li C. Phase Ib/II study of cancer stem cell (CSC) inhibitor BBI608 combined with paclitaxel in advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma. In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology. 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # 4069. 461. Grothey A, Falcone A, Humblet Y, Bouche O, Mineur L, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Xu L, Wagner A, Van Cutsem E. Subgroup analysis of patients with metastatic colorectal cancer (mCRC) treated with regorafenib (REG) in the CORRECT trial who had progression-free survival (PFS) longer than 4 months. . In: Proceedings of the 51st Annual Meeting of the American Society of Clinical Oncology. 2015 May 29 – June 2; Chicago, Illinois: ASCO Abstract # E14579. 462. Elez E, Schellens J, Van Geel R, Bendell J, Spreafico A, Schuler M, Yoshino T, Delord JP, Yamada Y, Lolkema M, Faris JE, Eskens F, Sharma S, Yaeger R, Lenz HJ, Wainberg Z, Avsar E, Chatterjee A, Jaeger S, Demuth T, Tabernero J. Results of a phase 1B study of the selective BRAF V600 inhibitor encorafenib in cambination with cetuximab alone or cetuximab + alpelisib for treatment of patients with advanced BRAF-mutant metastatic colorectal cancer. In: Proceedings of ESMO 17th World Congress on GI Cancer. 2015 July 1-4; Barcelona, Spain: Annuals of Oncology 26;(4).ESMO Abstract# LBA-08. 463. Falcone A, Laurent S, Gravalos C, Benavides M, Longo Munoz F, Ychou M, Ciardiello F, Siena S, Yamaguchi K, Muro K, Denda T, Tsuji Y, Tebbutt N, Loehrer PJ, Lenz HJ, Mayer RJ, Ohtsu A, Van Cutsem E. Phase 3 RECORSE trial of TAS-102 versus placebo with best supportive care in patients with metastatic colorectal cancer: European subgroup. In: Proceedings of ESMO 17th World Congress on GI Cancer. 2015 July 1-4; Barcelona, Spain: Annuals of Oncology 26;(4). ESMO Abstract# P -284. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 148 of 173

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524. Lenz HJ, Yoshino T, Argiles G, Iveson T, Sastre J, Harrison M, Lim HJ, Tebbutt NC, Peeters M, Satoh T, Dittrich C, Sassi M, Loembe A-B, Van Cutsem E. Nintedanib (N) plus best supportive care (BSC) versus placebo (P) plus BSC for the treatment of patients (pts) with colorectal cancer (CRC) refractory to standard therapies: Subanalysis of the phase III LUME-colon 1 study in pts by prior regorafenib (R) treatment. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 660. 525. Lenz HJ, Tabernero J, Yoshino T, Lonardi S, Falcone A, Limón Mirón ML, Saunders MP, Sobrero AF, Suk Park Y, Monteagudo RF, Sang Hong Y, Tomasek J, Taniguchi H, Ciardiello F, Sassi M, Peil B, Hastedt C, Studeny M, Van Cutsem E. Nintedanib (N) plus best supportive care (BSC) versus placebo plus BSC for the treatment of patients (pts) with metastatic colorectal cancer (mCRC) refractory to standard therapies: Health- related quality of life (HRQoL) results of the Phase III LUME-Colon 1 study. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 671. 526. Barzi A, Siegel R, Fedewa SA, Lenz HJ, Quinn DI, Jemal A, Sadeghi S. Comparative effectiveness of initiating colorectal cancer (CRC) screening (Scr) at age 45. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 531. 527. Qureshi S, Xiu J, Sarraf Yazdy M, Shields AF, Agop P, Marshall J, Lenz HJ, Salem ME. Molecular characterization of early vs. late onset gastroesophageal cancers. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 46. 528. Berger MD, Stintzing S, Yang D, Suenaga M, Miyamoto Y, Cao S, Soni S, Gopez R, Hanna HL, Zhang W, Heinemann V, Lenz HJ. Effect of polymorphisms of genes encoding regulatory proteins in the coagulation cascade on outcome for mCRC patients treated with FOLFIRI and bevacizumab: Data from FIRE-3 trial. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 601. 529. Weinberg BA, Lenz HJ, Arguello D, El-Deiry WS, Xiu J, Gatalica Z, Liu Z, Chen S, El Ghazaly H, Hwang JJ, Philip PA, Shields AF, Marshall J, Salem ME. Molecular characterization of squamous cell carcinoma of the anal canal (SCCA). 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 538. 530. Kopetz S, McDonough SL, Van Karlyle Morris VK, Lenz HJ, Magliocco AM, Atreya CE, Diaz LA, Allegra CJ, Wang SE, Hanyoung Lieu C, Eckhardt GS, Semrad TJ, Kaberle K, Guthrie KA, Hochster HS. Randomized trial of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (SWOG 1406). 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 520. 531. Berger MD, Stintzing S, Heinemann V, Yang D, Cao S, Ning Y, Okazaki S, Miyamoto Y, Suenaga M, Schirripa M, Gopez R, Hanna DL, Zhang W, Lenz HJ. Effect of JAK2 SNP rs2274472 on outcome for mCRC patients treated with first-line FOLFIRI and bevacizumab: Data from FIRE-3 trial. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 595. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 158 of 173

532. Miyamoto Y, Stintzing S, Zhang W, Cao S, Ning Y, Okazaki S, Berger MD, Suenaga M, Schirripa M, Soni S, Matsusaka S, Yang D, Gopez R, Hanna DL, Barzi A, Baba H, Heinemann V, Lenz HJ. Polymorphisms in adipokine-related genes to predict treatment outcomes in patients (pts) with metastatic colorectal cancer (mCRC) treated with bevacizumab-based chemotherapy. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 600. 533. Marshall J, Lenz HJ, Xiu J, El-Deiry WS, Swensen J, El Ghazaly H, Gatalica Z, Hwang JJ, Philip PA, Shields AF, Salem ME. Molecular variances between rectal and left-sided colon cancers. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 522. 534. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Salvatore L, Lonardi S, Moretto R, Borelli B, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Gopez R, Hanna DL, Barzi A, Wakatsuki T, Yamaguchi T, Loupakis F, Lenz HJ. Genetic variants of genes in CCL5/CCR5 pathway to predict regorafenib-induced hand-foot skin reaction in patients with refractory metastatic colorectal cancer: A report of ethnic difference. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 615. 535. Hurwitz H, Tan BR, Reeves AJ, Xiong HQ, Somer BG, Lenz HJ, Hochster HS, Scappaticci F, Palma JF, Mancao C, Lee JJ, Nicholas A, Sommer N, Bendell JC. Updated efficacy, safety, and biomarker analyses of STEAM, a randomized, open- label, phase II trial of sequential (s) and concurrent (c) FOLFOXIRI-bevacizumab (BV) vs FOLFOX-BV for first-line (1L) treatment (tx) of patients with metastatic colorectal cancer (mCRC). 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19- 21; San Francisco, CA; Suppl 4S; Abstract # 657. 536. Salem ME, Xiu J, Weinberg BA, El-Deiry WS, Weiner LM, Gatalica Z, Liu Z, El Ghazaly H, Xiao N, Hwang JJ, Philip PA, Shields AF, Lenz HJ, Marshall J. Characterization of tumor mutation burden (TMB) in gastrointestinal (GI) cancers. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 530. 537. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Marmorino F, Bergamo F, Antoniotti C, Rossini D, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Gopez R, Hanna DL, Barzi A, Mashima T, Yamaguchi T, Loupakis F, Lenz HJ. Role of genetic polymorphisms in CCL5/CCR5 axis to predict efficacy of regorafenib in patients with refractory metastatic colorectal cancer. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 596. 538. Overman MJ, Lonardi S, Leone F, McDermott RS, Morse MA, Wong KYM, Neyns B, Leach JL, Garcia Alfonso P, Lee JJ, Hill A, Lenz HJ, Desai J, Moss RA, Cao ZA, Ledeine JM, Tang H, Kopetz S, Andre T. Nivolumab in patients with DNA mismatch repair deficient/microsatellite instability high metastatic colorectal cancer: Update from CheckMate 142. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19- 21; San Francisco, CA; Suppl 4S; Abstract # 519. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 159 of 173

539. Guercio BJ, Venook AP, Niedzwiecki D, Zhang S, Sato K, Fuchs CS, Lenz HJ, Innocenti F, Fruth B, Van Blarigan E,O'Neil BH, Shaw JE, Polite BN, Hochster HS, James Norman Atkins, Richard M. Goldberg, Robert J. Mayer, Bertagnolli MM, Blanke CD, Meyerhardt JA. Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance). 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 659. 540. Janku M, Barzi A, Sartore-Bianchi A, Fujii T, Cassingena A, Siravegna G, Karp DD, Piha-Paul SA, Subbiah V, Tsimberidou AM, Huang HJ, Veronese S, Di Nicolantonio F, Erlander MG, Luthra R, Kopetz S, Meric-Bernstam F, Siena S, Lenz HJ, Bardelli A. Mutation enrichment next-generation sequencing for quantitative detection of KRAS mutations in urine cell-free DNA from patients with advanced colorectal and other cancers. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 602. 541. Ohtsu A, Yoshino T, Falcone A, Garcia-Carbonero R, Argiles G, Sobrero AF, Peeters M, Makris L, Benedetti FM, Zaniboni A, Shimada Y, Yamazaki K, Komatsu Y, Rochster HS, Lenz HJ, Tran B, Yoshida K,Van Cutsem E, Mayer RJ. Onset of neutropenia as an indicator of treatment response in the phase 3 RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo in patients with metastatic colorectal cancer. 2017 Gastrointestinal Cancers Symposium Poster Session C; Jan 19-21; San Francisco, CA; Suppl 4S; Abstract # 775. 542. Venook AP, Ou F-S, Lenz H-J, Kabbarah O, Qu X, Niedzwiecki D, Zemla T, Goldberg RM, Hochster HS, O'Neil BH, Sanoff HK, Mayer RJ, Bertagnolli MM, Blanke CD, Innocenti F. Primary tumor location as an independent prognostic marker from molecular features for overall survival in patients with metastatic colorectal cancer: analysis of CALGB/SWOG 80405 (Alliance). In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Oral Abstract Session, J Clin Onc 35(15S): Abstract #3503. 543. Kopetz S, McDonough SL, Lenz H-J, Magliocco AM, Atreya CE, Diaz LA, Allegra CJ, Singh Raghav KP, MorrisVK, Wang SE, Lieu CH, Guthrie KA, Hochster HS. Randomized trial of irinotecan and cetuximab with or without vemurafenib in BRAF- mutant metastatic colorectal cancer (SWOG S1406). In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Oral Abstract Session, J Clin Onc 35(15S): Abstract #3505. 544. Stintzing S, Wirapati P, Lenz H-J, Neureiter D, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran S-E, Heintges T, Kahl C, Kullmann F, Moehler MH, Scheithauer W, Held S, Modest DP, Jung A, Kirchner T, Tejpar S, Heinemann V. Consensus Molecular Subgroups (CMS) of Colorectal Cancer (CRC) and 1st Line Efficacy of FOLFIRI Plus Cetuximab or Bevacizumab: Analysis of the FIRE-3 (AIO KRK 0306) Study. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Oral Abstract Session, J Clin Onc 35(15S): Abstract #3510. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 160 of 173

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551. Suenaga M, Cao S, Stintzing S, Zhang W, Yang D, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Gopez R, Melendez E, Soni S, Barzi A, Yamaguchi T, Heinemann V, Lenz H-J. Genetic polymorphisms of CCL5 and CCR5 to predict efficacy of cetuximab-based treatment in metastatic colorectal cancer patients depending on primary tumor location. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #3594. 552. Suenaga M, Cao S, Zhang W, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Gopez R, Melendez E, Soni S, Barzi A, Yamaguchi T, Lenz H-J. Genetic variants in CCL5 and CCR5 genes and serum VEGF-A levels to predict efficacy of bevacizumab in metastatic colorectal cancer patients receiving first-line chemotherapy. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #11564. 553. Iqbal S, McDonough S, Lenz H-J, Ilson DH, Burtness B, Singh Nangia C, Barzi A, Schneider C, Liu J, Dotan E, Guthrie KA, Hochster HS. A randomized phase II pilot study prospectively evaluating treatment for patients based on ERCC1 for advanced/ metastatic esophageal, gastric, or gastroesophageal junction cancer: SWOG S1201. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #4009. 554. Barzi A, Hershman DL, Till C, Lenz H-J, Hochster HS, Unger JM. Patterns of osteoporosis (OP) in survivors of colorectal cancer (CRC) enrolled on SWOG trials. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #10056. 555. Berger MD, Stintzing S, Yang D, Cao S, Miyamoto Y, Suenaga M, Soni S, Gopez R, Melendez E, Zhang W, Heinemann V, Lenz H-J. Genetic variations within the vitamin C transporter genes to predict outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: Data from FIRE-3 trial. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2- 6; Chicago, Illinois; ASCO Oral Abstract Session, J Clin Onc 35(15S): Abstract #11507. 556. Salem ME, Xiu J, Lenz H-J, Atkins MB, Philip PA, Hwang JJ, Gatalica Z, Xiao N, Gibney GT, El-Deiry WS, Tan AR, Kim ES, Shields AF, Raghavan D, Marshall J. Characterization of tumor mutation load (TML) in solid tumors. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #11517. 557. Miyamoto Y, Loupakis F, Zhang W, Cao S, Okazaki S, Berger MD, Suenaga M, Schirripa M, Soni S, Matsusaka S, Ning Y, Yang D, Gopez R, Melendez E, Hanna DL, Barzi A, Baba H, Falcone A, Lenz H-J. Genetic variations in semaphorin/neuropilin signaling to predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) receiving bevacizumab-based chemotherapy. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #11608. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 162 of 173

558. Sunakawa Y, Yang D, LaFleur B, Luecke J, Thompson D, Moran M, Astrow SH, Hsiang J, Zhang W, Tsuji A, Takahashi T, Tanioka H, Negoro Y, Takagane A, Tani S, Yamaguchi T, Eto T, Fujii M, Ichikawa W, Lenz H-J. Association of immune-related genes to neutrophil-lymphocyte ratio (NLR) with survival of cetuximab treatment for metastatic colorectal cancer (mCRC): JACCRO CC-05/06AR. In: Proceedings of the 53rd Annual Meeting of the American Society of Clinical Oncology; 2017, June 2-6; Chicago, Illinois; ASCO Poster Session, J Clin Onc 35(15S): Abstract #11613. 559. Salem ME, Xiu J, Puccini A, Philip PA, Goldberg RM, Hwang JJ, Kc B, Korn WM, hields AF, Lenz H-J, John Marshall J. Molecular characterization of intestinal (IS) and diffuse subtypes (DS) of gastric adenocarcinomas. 2018 Gastrointestinal Cancers Symposium Poster Session A; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #60. 560. Thomas JS, Lenz H-J, Iqbal S, Tsao-Wei DD, Barzi A, Duddalwar V, Cole S, Rehman R, Menendez X, Krasnoperov V, Liu R, Feng Q, Gill PS, El-Khoueiry AB. A first-in- human phase I study of sEphB4-HSA (sEphB4) with expansion in hepatocellular (HCC) and cholangiocarcinoma (CCA). 2018 Gastrointestinal Cancers Symposium Poster Session B; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #285. 561. Andre T, Lonardi S, Wong M, Lenz H-J, Gelsomino F, Aglietta M, Morse M, Van Cutsem E, McDermott RS, Hill AG, Sawyer MB, Hendlisz A, Neyns B, Svrcek M, Moss RA, Ledeine J-M, Z. Cao A, Kamble S, Kopetz S, Overman MJ. Nivolumab + ipilimumab combination in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC): First report of the full cohort from CheckMate-142. 2018 Gastrointestinal Cancers Symposium Oral Abstract Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #553. 562. Bekaii-Saab TS, Ou F-S, Anderson DM, Ahn DH, Boland PM, Ciombor KK, Jacobs NL, Desnoyers RJ, Cleary JM, Meyers JP, Chiorean EG, Pedersen K, Barzi A, Sloan J, McCune JS, Lacouture ME, Lenz H-J, Grothey A. Regorafenib dose optimization study (ReDOS): Randomized phase II trial to evaluate dosing strategies for regorafenib in refractory metastatic colorectal cancer (mCRC)—An ACCRU Network study. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #611. 563. Barzi A, Salem ME, Xiu J, Korn WM, Marshall J, Shields AF, Lenz H-J. Differences in molecular profiles of males and females with colorectal cancer (CRC). 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #623. 564. Berger MD, Zlobec I, Yang D, Cao S, Sunakawa Y, Matsusaka S, Koelzer VH, Inderbitzin D, Ning Y, Okazaki S, Miyamoto Y, Suenaga M, Schirripa M, Soni S, Puccini A, Tokunaga R, Naseem M, Zhang W, Lugli A, Lenz H-J. Association of genetic variations within the PD-L2 immune checkpoint gene with outcome in stage II and III colon cancer. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #626. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 163 of 173

565. Sunakawa Y, Satake H, Usher JL, Jaimes YS, Miyamoto Y, Nakamura M, Nakayama H, Sugano N, Takagane A, Gotoh M, Watanabe T, Ishigure K, Tanaka C, Takeuchi M, Fujii M, Danenberg K, Lenz H-J, Sekikawa T, Ichikawa W. Initial therapy with FOLFOXIRI plus bevacizumab (bev) for RAS mutant metastatic colorectal cancer (mCRC) and gene mutations in circulating tumor DNA (ctDNA) as a predictive marker for the efficacy: JACCRO CC-11. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #635. 566. Sehdev A, Niedzwiecki D, Venook AP, Lenz H-J, Innocenti F, Mahoney MR, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg R, Mayer RJ, Schilsky RL, Bertagnolli MM, Blanke CD, O'Neil BH. Association of RAS mutations with race in metastatic colorectal cancer: CALGB/SWOG 80405 (ALLIANCE). 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #638. 567. Puccini A, Berger MD, Tokunaga R, Naseem M, Battaglin F, Cao S, Millstein J, Soni S, McSkane M, Zhang W, Loupakis F, Stintzing S, Heinemann V, Falcone A, Lenz H- J. Polymorphism in cancer-associated fibroblasts (CAFs) related genes and clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) enrolled in two independent randomized phase III trials: TRIBE and FIRE-3. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #645. 568. Puccini A, Loupakis F, Stintzing S, Berger MD, Tokunaga R, Naseem M, Battaglin F, Cao S, Millstein J, Soni S, McSkane M, Zhang W, Heinemann V, Falcone A, Lenz H- J. Genetic variants in methylation and demethylation pathways to predict clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) treated with first-line FOLFIRI/Bev: Data from TRIBE and FIRE-3 trials. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #646. 569. Tokunaga R, Cao S, Zhang W, Puccini A, Berger MD, Naseem M, Battaglin F, Soni S, McSkane M, Stintzing S, Loupakis F, Heinemann V, Falcone A, Millstein J, Lenz H-J. The impact of Tfh cell/ B cell pathway-related genetic variants in metastatic colorectal cancer patients with bevacizumab-based chemotherapy. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #651. 570. Naseem M, Berger MD, Puccini A, Tokunaga R, Battaglin F, Barzi A, Soni S, McSkane M, Cao S, Millstein J, Zhang W, Loupakis F, Stintzing S, Heinemann V, Falcone A, Lenz H-J. Polymorphisms in beta-defensin pathways and clinical outcomes in metastatic colorectal cancer patients treated with FOLFIRI-bevacizumab in two randomized phase III trials. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #662. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 164 of 173

571. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Cremolini C, Murgioni S, Lonardi S, Ning Y, Okazaki S, Berger MD, Miyamoto Y, Gopez R, Barzi A, Loupakis F, Falcone A, Lenz H-J. Single nucleotide polymorphisms in miRNA binding sites of nucleotide excision repair-related genes to predict clinical benefit of oxaliplatin in FOLFOXIRI plus bevacizumab in TRIBE trial. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #663. 572. Barzi A, Campan M, Petterson J, Du L, Long T, Dubeau L, Lenz H-J, Ward P. Assessment of microsatellite instability (MSI) in cell free DNA (cfDNA) of colorectal cancers (CRC) patients (pts). 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #672. 573. Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Ning Y, Bergamo F, Zagonel V, Rossini D, Borelli B, Okazaki S, Berger MD, Miyamoto Y, Gopez R, Barzi A, Yamaguchi T, Loupakis F, Lenz H-J. Matrix metalloproteinase-related gene polymorphisms to predict efficacy of regorafenib in patients with metastatic colorectal cancer. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; Suppl 4S; Abstract #692. 574. Loupakis F, Hurwitz HI, Saltz L, Arnold D, Grothey A, Nguyen QL, Osborne S, Yau L, Talbot J, Srock S, Lenz H-J. Efficacy outcomes with bevacizumab added to chemotherapy (bev+CT) compared with chemotherapy alone (CT) in left- and right- sided tumors in metastatic colorectal cancer (mCRC). 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #726. 575. Kopetz S, Spira AI, Wertheim M, Kim E, Tan BR, Lenz H-J, Nikolinakos P, Rich P, Smith DA, Helwig C, Dussault I, Ojalvo L, Gulley JL. M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in patients with heavily pretreated CRC: Preliminary results from a phase I trial. 2018 Gastrointestinal Cancers Symposium Poster Session C; Jan 18-20; San Francisco, CA; J Clin Oncol 36 (Suppl 4S); Abstract #764. 576. Davis SL, Cardin DB, Shahda S, Lenz H-J, Dotan E, O'Neil BH, Kapoun AM, Stagg RJ, Berlin J, Messersmith WA, Cohen SJ. A phase 1b dose escalation study of vantictumab (VAN) in combination with nab-paclitaxel (Nab-P) and gemcitabine (G) in patients with previously untreated stage IV pancreatic cancer. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #237077 577. Suenaga M, Cao S, Zhang W, Matsusaka S, Okazaki S, Berger MD, Miyamoto Y, Schirripa M, Barzi A, Ueno M, Lenz H-J. Role of enterocyte-specific gene polymorphisms in adjuvant treatment for stage III colorectal cancer. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #239735 578. Battaglin F, Puccini A, Cao S, Millstein J, Tokunaga R, Naseem M, Soni S, Lo JH, Ning T, Arai H, Berger MD, Barzi A, Zhang W, Heinemann V, Stintzing S, Lenz H-J. Genetic variants in the lipopolysaccharide (LPS) receptor complex and TLR4 expression levels to predict efficacy of cetuximab (cet) in patients (pts) with metastatic colorectal cancer (mCRC): data from the FIRE-3 phase III trial. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #240589 Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 165 of 173

579. Battaglin F, Loupakis F, Stintzing S, Cao S, Puccini A, Tokunaga R, Naseem M, Berger MD, Soni S, Lo JH, Bergamo F, Lonardi S, Millstein J, Zhang W, Zagonel V, Cremolini C, Falcone A, Heinemann V, Lenz H-J. Polymorphisms in the telomerase complex to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): data from TRIBE and FIRE-3 phase III trials. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #240615 580. Cerniglia M, Xiu J, Grothey A, Pishvaian MJ, Hwang JJ, Marshall J, Vanderwalde AM, Shields AF, Lenz H-J, Salem ME, Philip PA, Goldberg RM, Korn WM, Kim SS. Association of DNA damage response and repair genes (DDR) mutations and microsatellite instability (MSI), PD-L1 expression, Tumor mutational burden (TMB) in gastroesophageal cancers. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #240729 581. Puccini A, Poorman K, Salem ME, Goldberg RM, Shields AF, Berger MD, Battaglin F, Tokunaga R, Naseem M, Zhang W, Soni S, Korn WM, Philip PA, Marshall J, Lenz H- J. Comprehensive molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon. 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #240821 582. Hall MJ, Bodor JN, Xiu J, Feldman R, Grothey A, Goldberg RM, Worrilow WM, Hwang JJ, Kim ES, Lenz H-J, Raghavan D, Shields AF, Marshall J, Korn WM, Salem ME. Gene-specific features (MLH1, MSH2, MSH6, PMS2) of mismatch repair (MMR) protein expression and somatic mutations (muts), microsatellite instability (MSI) and tumor mutational burden (TMB) in MSI-H and MMR-mutated tumor genomic profiles (TGPs). 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #240917 583. Hatch AJ, Ou F-S, Zemla T, Starr MD, Brady JC, Liu Y, Innocenti F, Meyerhardt JA, O'Reilly EM, Lenz H-J, Hurwitz H, Venook AP, Nixon AB. On-treatment changes of plasma protein biomarkers in CALGB/SWOG 80405 (Alliance). 2019 Gastrointestinal Cancers Symposium; Jan 17-19; San Francisco, CA; J Clin Oncol 37; Abstract #241279 584. Tokunaga R, Cao S, Battaglin F, Lo JH, Loupakis F, Stintzing S, Naseem M, Puccini A, Berger MD, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Heinemann V, Falcone A, Millstein J, Lenz H-J. Th17 cell pathway-related genetic variants in metastatic colorectal cancer: a meta-analysis using TRIBE, MAVERICC, and FIRE-3. 2019 Gastrointestinal Cancers Symposium; Jan 17- 19; San Francisco, CA; J Clin Oncol 37; Abstract #241417 585. Barzi A, Cho SK, Hay JW, Lenz H-J, Ou F-S, Grothey A, Bekaii-Saab TS. Cost- effectiveness (CE) of regorafenib dose optimization schedule in metastatic colorectal cancer. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Health Services Research, Clinical Informatics, and Quality of Care. J Clin Oncol 37, 2019 (suppl; abstr e18367). 586. Yu Sunakawa, Joshua L. Usher, Yolanda S Jaimes, Akihito Tsuji, Manabu Shiozawa, Takanori Watanabe, Hironaga Satake, Hirofumi Ota, Mitsugu Kochi, Hisatsugu Ohori, Dai Manaka, Masato Matsuura, Masahiro Takeuchi, Peter V. Danenberg, Masashi Fujii, Wataru Ichikawa, Heinz-Josef Lenz, Kathleen Danenberg. Clinical verification of circulating tumor RNA (ctRNA) as novel pretreatment predictor and tool for quantitative monitoring of treatment response in metastatic colorectal cancer (mCRC): A biomarker study of the DEEPER trial. 2019 ASCO Annual Meeting; May Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 166 of 173

29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 110A. J Clin Oncol 37, 2019 (suppl; abstr TPS3621). 587. Martin D. Berger, Shu Cao, Inti Zlobec, Yuji Miyamoto, Mitsukuni Suenaga, Diana L. Hanna, Shivani Soni, Alberto Puccini, Ryuma Tokunaga, Madiha Naseem, Francesca Battaglin, Wu Zhang, Alessandro Lugli, Heinz-Josef Lenz. Association of genetic variations within the T-cell costimulatory LIGHT gene with outcome in stage II and III colon cancer. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Developmental Immunotherapy and Tumor Immunobiology - Poster 277. J Clin Oncol 37, 2019 (suppl; abstr 2633). 588. Brendan John Guercio, Alan P. Venook, Sui Zhang, Fang-Shu Ou, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Michael N. Pollak, Andrew B. Nixon, Michelle R. Mahoney, Bert O'Neil, James Edward Shaw, Blase N. Polite, Crystal S. Denlinger, James Norman Atkins, Richard M. Goldberg, Robert J. Mayer, Charles David Blanke, Charles S. Fuchs, Jeffrey A. Meyerhardt. Associations of insulin-like growth factor binding proteins and adiponectin with disease progression and mortality in metastatic colorectal cancer: Results from CALGB/SWOG 80405 (Alliance). 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Developmental Therapeutics and Tumor Biology (Nonimmuno) - Poster 27. J Clin Oncol 37, 2019 (suppl; abstr 3035). 589. Francesca Battaglin, Shu Cao, Fotios Loupakis, Sebastian Stintzing, Aparna Raj Parikh, Alberto Puccini, Ryuma Tokunaga, Madiha Naseem, Martin D. Berger, Hiroyuki Arai, Joshua Millstein, Sara Lonardi, Wu Zhang, Chiara Cremolini, Christoph Mancao, Alfredo Falcone, Volker Heinemann, Heinz-Josef Lenz. Polymorphisms in the dopamine (DA) signaling to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from TRIBE, MAVERICC, and FIRE-3 phase III trials. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Developmental Therapeutics and Tumor Biology (Nonimmuno) - Poster 40. J Clin Oncol 37, 2019 (suppl; abstr 3048). 590. Alberto Puccini, Joanne Xiu, Richard M. Goldberg, Axel Grothey, Anthony Frank Shields, Mohamed E. Salem, Andreas Seeber, Francesca Battaglin, Martin D. Berger, Wafik S. El-Deiry, Ryuma Tokunaga, Madiha Naseem, Wu Zhang, Sukeshi Patel Arora, Moh'd M. Khushman, Michael J. Hall, Philip Agop Philip, John Marshall, Wolfgang Michael Korn, Heinz-Josef Lenz 591. Molecular differences between lymph nodes (LNs) and distant metastases (mets) in colorectal cancer (CRC). 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Development Therapeutics and Tumor Biology (Nonimmuno) - Poster 122. J Clin Oncol 37, 2019 (suppl; abstr 3130). 592. Madiha Naseem, Shu Cao, Sebastian Stintzing, Fotios Loupakis, Martin D. Berger, Alberto Puccini, Ryuma Tokunaga, Francesca Battaglin, Afsaneh Barzi, Shivani Soni, Joshua Millstein, Mohamed E. Salem, Chiara Cremolini, Wu Zhang, Volker Heinemann, Alfredo Falcone, Heinz-Josef Lenz. BRCA1 genetic variant to predict survival in metastatic colorectal cancer (mCRC) patients (pts) treated with FOLFIRI/bevacizumab (bev): Results from phase III TRIBE and FIRE-3 trials. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Developmental Therapeutics and Tumor Biology (Nonimmuno) - Poster 137. J Clin Oncol 37, 2019 (suppl; abstr 3145). 593. Heinz-Josef Lenz, Sara Lonardi, Vittorina Zagonel, Eric Van Cutsem, M. Luisa Limon, Ka Yeung Mark Wong, Alain Hendlisz, Massimo Aglietta, Pilar Garcia- Alfonso, Bart Neyns, Dana Backlund Cardin, Andrea Spallanzani, Tomislav Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 167 of 173

Dragovich, Usman Shah, Ajlan Atasoy, Jean-Marie Ledeine, Michael J. Overman. Nivolumab (NIVO) + low-dose ipilimumab (IPI) as first-line (1L) therapy in microsatellite instability-high/DNA mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): Clinical update. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 13. J Clin Oncol 37, 2019 (suppl; abstr 3521). 594. Ofer Margalit, William S. Harmsen, Einat shacham-Shmueli, Molly Petersen, Ben Boursi, Leonard B. Saltz, Richard Adams, Tim Maughan, Jean-Yves Douillard, Eric Van Cutsem, Herbert Hurwitz, Carsten Bokemeyer, Niall C. Tebbutt, Fairooz F. Kabbinavar, Aimery De Gramont, Qian Shi, Heinz-Josef Lenz. Evaluating gender as a predictive marker for response to bevacizuamb (Bev) in metastatic colorectal carcinoma (mCRC): Pooled analysis of 3369 patients (pts) in the ARCAD database. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 31. J Clin Oncol 37, 2019 (suppl; abstr 3539). 595. Hiroyuki Arai, Shu Cao, Fotios Loupakis, Sebastian Stintzing, Ryuma Tokunaga, Francesca Battaglin, Jae Ho Lo, Shivani Soni, Wu Zhang, Christoph Mancao, Bodour Salhia, Shannon M Mumenthaler, Daniel J Weisenberger, Gangning Liang, Chiara Cremolini, Volker Heinemann, Alfredo Falcone, Joshua Millstein, Heinz-Josef Lenz. Genetic variants in RNA binding protein (RBP) to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3, TRIBE, and MAVERICC trials. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 37. J Clin Oncol 37, 2019 (suppl; abstr 3545) 596. Alberto F. Sobrero, Heinz-Josef Lenz, Cathy Eng, Werner Scheithauer, Gary William Middleton, Wen-Feng Chen, Regina Esser, Johannes Nippgen, Howard A. Burris. Retrospective analysis of overall survival (OS) by subsequent therapy in patients (pts) with RAS wild-type (wt) metastatic colorectal cancer (mCRC) receiving irinotecan ± cetuximab in the EPIC study. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 72. J Clin Oncol 37, 2019 (suppl; abstr 3580). 597. Andreas Seeber, Florian Kocher, Joanne Xiu, Gilbert Spizzo, Alberto Puccini, Jeffrey Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony Frank Shields, Mohamed E. Salem, Francesca Battaglin, Wafik S. El-Deiry, Ryuma Tokunaga, Madiha Naseem, Philip Agop Philip, John Marshall, Wolfgang Michael Korn, Heinz- Josef Lenz, Zoran Gatalica. Molecular landscape of colorectal cancers harboring R- spondin fusions. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 80. J Clin Oncol 37, 2019 (suppl; abstr 3588). 598. Francesca Battaglin, Shu Cao, Alberto Puccini, Ryuma Tokunaga, Madiha Naseem, Hiroyuki Arai, Martin D. Berger, Tricia Ning, Shivani Soni, Jae Ho Lo, Afsaneh Barzi, Joshua Millstein, Wu Zhang, Volker Heinemann, Sebastian Stintzing, Heinz-Josef Lenz. Gene expression and genetic variants in Parkinson's disease (PD) genes to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3 phase III trial. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 87. J Clin Oncol 37, 2019 (suppl; abstr 3595). 599. Ryuma Tokunaga, Joanne Xiu, Richard M. Goldberg, Philip Agop Philip, Andreas Seeber, Francesca Battaglin, Hiroyuki Arai, Jae Ho Lo, Alberto Puccini, Madiha Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 168 of 173

Naseem, Martin D. Berger, Shivani Soni, Wu Zhang, Wangjuh Sting Chen, Jimmy J. Hwang, Anthony Frank Shields, John Marshall, Hideo Baba, W. Michael Korn, Heinz- Josef Lenz. Gene mutations of SWI/SNF complex and molecular profile in colorectal cancer. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Colorectal) Cancer - Poster 92. J Clin Oncol 37, 2019 (suppl; abstr 3600). 600. Matthew K Stein, Joanne Xiu, Michael Gary Martin, Axel Grothey, Philippe Prouet, Jeffrey Owsley, Forrest W Williard, Evan Scott Glazer, Paxton Vandiver Dickson, David Shibata, Danny Yakoub, Richard M. Goldberg, W. Michael Korn, Anthony Frank Shields, Jimmy J. Hwang, Heinz-Josef Lenz, Jeremiah Lee Deneve. Molecular comparison between peritoneal metastases (PM) and primary gastric (GC) and gastroesophageal junction (GEJ) cancer. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Noncolorectal) Cancer - Poster 158. J Clin Oncol 37, 2019 (suppl; abstr 4053). 601. Gilbert Spizzo, Alberto Puccini, Joanne Xiu, Richard M. Goldberg, Axel Grothey, Anthony Frank Shields, Sukeshi Patel Arora, Moh'd M. Khushman, Mohamed E. Salem, Francesca Battaglin, Wafik S. El-Deiry, Ryuma Tokunaga, Philip Agop Philip, Michael J. Hall, John Marshall, Florian Kocher, Wolfgang Michael Korn, Heinz-Josef Lenz, Andreas Seeber. Frequency of BRCA mutation in biliary tract cancer and its correlation with tumor mutational burden (TMB) and microsatellite instability (MSI). 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Noncolorectal) Cancer - Poster 190. J Clin Oncol 37, 2019 (suppl; abstr 4085). 602. Andreas Seeber, Alberto Puccini, Joanne Xiu, Richard M. Goldberg, Axel Grothey, Anthony Frank Shields, Mohamed E. Salem, Francesca Battaglin, Wafik S. El-Deiry, Ryuma Tokunaga, Philip Agop Philip, John Marshall, Florian Kocher, Michael J. Hall, Wolfgang Michael Korn, Heinz-Josef Lenz, Gilbert Spizzo. Association of BRCA- mutant pancreatic cancer with high tumor mutational burden (TMB) and higher PD-L1 expression. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Gastrointestinal (Noncolorectal) Cancer - Poster 238. J Clin Oncol 37, 2019 (suppl; abstr 4133). 603. Aminah Jatoi, Fang-Shu Ou, Daniel H. Ahn, Patrick McKay Boland, Kristen Keon Ciombor, Nisha Lassi Jacobs, Boris Pasche, James M. Cleary, Jeannine S. McCune, Katrina Pedersen, Afsaneh Barzi, E. Gabriela Chiorean, Erica N. Heying, Heinz-Josef Lenz, Jeff A. Sloan, Mario E. Lacouture, Axel Grothey, Tanios S. Bekaii-Saab. Preemptive versus reactive topical clobetasol for regorafenib-induced hand-foot reactions: Results from the ReDOS trial. 2019 ASCO Annual Meeting; May 29-Jun 4; Chicago, IL; Symptoms and Survivorship - Poster 278. J Clin Oncol 37, 2019 (suppl; abstr 11586).

Chapters 1. Lenz, H-J. Bestimmung der Androstendionspiegel im Serum von Kindern mit Ullrich- Turner…In: Cancer Gene Therapy, 1989. 2. Lenz H-J, Danenberg KD, Danenberg PV: Quantitative measurement of relative gene expression in human tumors. In: Reverse Transcriptase PCR. Simon and Schuster, 1994. 3. Lenz HJ, Hill C, Danenberg K, Leichman L, Priest DG, Danenber PV. Rapid Quantitative PCR for Determination of Relative Gene Expressions in Tissue Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 169 of 173

Specimens. In: PCR Methods and Applications, Volume 4. Cold Spring Harbor Laboratory Press. pp. 305-, 1995. 4. Iqbal S, Lenz H-J: Principles of adjuvant and neoadjuvant therapy: applications in gastric and pancreatic cancer. In: Surgical Oncology: Multidisciplinary Approach to Difficult Problems (1st edition; Silberman H, Silberman AW [editors]). Oxford University Press, New York, NY, pp574–584, 2002. 5. Schneider S, Stoehlmacher J, Lenz H-J: Pharmakogenetik in Kolorektalen Karzinomen. Der Onkologe. Band 9, Heft 8, 2003. 6. Stoehlmacher J, Iqbal S, Lenz H-J: Polymorphisms in genes of drug targets and metabolism, and DNA repair. In: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (1st Edition; William Figg, Howard McLeod [editors]). Human Press Inc., Totowa, NJ, pp231–243, 2004. 7. Vallbohmer D, Lenz H-J. Potential Response Prediction in the Neoadjuvant and Adjuvant Therapy of Esophageal and Gastric Cancer. In: Viszeralchirurgie 40: 249– 254, 2005. 8. Park DJ, Lenz H-J: Proteasome Inhibition in Its Clinical Application in Solid Tumors. In: The Oncogenomics Handbook. (Larochelle WJ, Shimkets RA [editors]). Human Press, Totowa, NJ. pp. 493-508, 2006. 9. El-Khoueiry A, Lenz HJ. Future directions in the treatment of colorectal cancer. In: Challenges in colorectal cancer, second edition. (Scholefield J, Maughan T, Abcarian H, Grothey A, [editors]). Blackwell Publishing, Oxford, England. pp. 251-270, 2006. 10. Lenz, H-J: Pharmacogenomics and Colorectal Cancer. In: New Trends in Cancer for the 21st Century – Advances in Experimental Medicine and Biology. (Lopez-Guerrero JA, Blombart-Bosch A, Felipo V, [editors]). Springer, New York. Volume 587; pp. 211-231, 2006. 11. Valböhmer D, Lenz HJ. Möglichkeiten der Response Prediction. Siewert, Rothmund, Schumpelick: Praxis der Viszeralchirurgie 2.Auflage, 2006. 12. El-Khoueiry A, Lenz HJ. Molecular biology and pharmacogenomics in GI cancers. In: Atlas of Gastrointestinal Cancers. Current Medicine, pp. 195-210, 2006. 13. El-Khoueiry A, Lenz HJ. Second line strategies in the treatment of patients with metastatic colorectal cancer. (Saltz LB, [editor]). In: Colorectal cancer: evidence based chemotherapy strategies. Humana Press, New York. pp. 119-130, 2007. 14. El-Khoueiry A, Lenz H-J. Personalized Medicine in the Clinical Management of Colorectal Cancer. In: Bioinformatics in Cancer and Cancer Therapy. (Gordon GJ, [editor]). Humana Press, Totowa, NJ. pp.155-172, 2008. 15. El-Khoueiry A, Lenz H-J. Pharmacogenomics. In: DeVita, Hellman, and Rosenberg’s Cancer Principles and Practice of Oncology, 8th Edition. pp. 402-406, 2008. 16. Lenz H-J. In: Esophageal Tumors: Principles and Practice. (Jobe BA, Thomas CR, Hunter JG, [editors]). Demos Medical Publishing, New York. In press, 2008. 17. Lurje G, Lenz H-J: Role of Thymidylate Synthase Gene Variations in Colorectal Cancer Patients. In: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response. (Innocenti F, [editor]). Humana Press, Totowa, NJ. pp. 151-172, 2008. 18. Lurje G, Lenz H-J: Rationale for Tailored Treatment. In: Esophageal Cancer: Principles and Practice. Demos Medical Publishing, New York. pp. 219-228, 2009. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 170 of 173

19. Park D, Lenz H-J: Cancer of the Pancreas: Adjuvant and Neoadjuvant Therapy. In: Principles and Practice of Surgical Oncology: A Multidisciplinary Approach to Difficult Problems. (Silberman H, Silberman AW, [editors]). Lippincott, Williams & Wilkins, Philadelphia, PA. pp. 694-704, 2009. 20. Winder T, Lenz H-J. Molecular Prognostic Markers In Colon Cancer. In: Metastasis of Colorectal Cancer. (Beauchemin N, Huot J, [editors]). Springer Science and Business Media B.V., The Netherlands. Volume 14; pp. 321-342, August 2010. 21. Lurge G, Lenz H-J. Molecular Response Prediction in Multimodality Treatment for Adenocarcinoma of the Esophagus and Esophagogastric Junction. In: Adenocarcinoma of the Esophagogastric Junction. (Schneider PM, [editor]). Springer-Verlag, Berlin- Heidelberg. pp. 179-186, 2010. 22. Lenz HJ. Biomarkers in Oncology. In: Prediction Markers in Clinical Development. 400 p., Humana Press 2011. 23. Paez D, Labonte MJ, Lenz HJ. Pancreatic Cancer: Medical Management (Novel Chemotherapeutics). In: Modern Management of Benign and Malignant Pancreatic Disease. (Jacques Van Dam, MD, PhD, [editors]). W.B. Sauders Company A Division of Elsevier Inc. Gastroenterology clinics of North America. Volume 41:(1), pp. 189- 211, 2012.

Panels / Media Appearances 1. Colon Cancer. Colon Cancer Chat Room, Wellness Community of the Foothills, Pasadena, CA, 7/27/1998. 2. Colorectal health. Interactive Web discussion, A Doctor in Your House.com Program, 1/27/1999. 3. Colon Cancer. GI Cancer Chat Room, Wellness Community of the Foothills, Pasadena, CA, 4/20/1999. 4. The latest advances in the diagnosis and treatment of colorectal cancer. Panel Discussion, The Group Room, Talk LA 1110 AM Radio, 3/5/2000. 5. Frankly speaking about colorectal cancer. Seminar, The Wellness Community of the Foothills, Pasadena, CA, 3/7/2000. 6. IM862 in colon cancer. Interview, CBS Channel 2, 4/1/2000. 7. Cancer genetics. Internet Live Q&A, WebMD, 4/14/2000. 8. Colorectal cancer: Vital Options. The Group Room, Talk LA 1110 AM Radio, Los Angeles, CA, 7/16/2000, 12/2/2002. 9. Colon cancer and genetic risk. DNA.com live internet chat, WebMD, 8/29/2000. 10. Frankly Speaking About Colorectal Cancer. Santa Monica Wellness Community, Santa Monica, CA, 3/15/2003. 11. Cancer Talk- Colorectal Cancer. Vital Options. Recorded via telephone.11/22/05. 12. Colon Cancer Special in Support of Colorectal Cancer Awareness Month. The Group Room Talk Radio, Encino, CA, 3/16/2003. 13. Colon Cancer. The Group Room Talk Radio, Encino, CA, 7/27/2003. 14. Colon and Carcinoid Tumors. The Wellness Community, Manhattan Beach, CA, 8/6/2003. 15. Cancer: The Next Frontier. The Hollywood Reporter, American Cancer Society, 11/10/2003. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 171 of 173

16. Colorectal Cancer Awareness Month. Group Room/Vital Options Radio Talk Show (Listener Question and Answer). Encino, CA, 3/14/2004. 17. Genetic profiling to predict response to 5-FU/platinum combinations – Colorectal Cancer Update. Conversations with Oncology research leaders: Bridging the gap between research and patient care, Audio Series (CD/Cassette) organized by Dr. Neil Love during the 2nd International Congress on Colorectal Cancer, Palm Beach, FL, (11/1/2003). Completed product received, 3/2004. 18. Colorectal Cancer Update- Research Leader Think Tank. Prognostic and predictive factors in systemic therapy, ongoing translational studies. Organized by Dr. Neil Love. Chicago, IL. July 30, 2004. 19. Strike Out Cancer and New Discoveries. Wellness Community. Redondo Beach, CA. 9/10/2005. 20. Colorectal Cancer Update- Think Tank. Conversations with Oncology Research Leaders. Bridging the Gap between Research and Patient Care. Organized by Dr. Neil Love. Chicago, IL. 2005. 21. Colorectal Cancer Update. Group Room/Vital Options Radio Talk Show. Encino, CA 10/23/2005. 22. Colorectal Cancer Awareness Month. Group Room/Vital Options Radio Talk Show (Listener Question and Answer). Encino, CA, 3/12/2006. 23. Erbitux Media Interview. Barcelona, Spain. 6/29/2006. 24. Colorectal Awareness Broadcast. Vital Options Radio Talk Show. Encino, CA. 2/25/2007. 25. Colorectal Cancer Update: Conversations with Oncology Investigators. Bridging the gap between reseach and patient care. Vol 6, Issue 1. 2007. 26. Merck Media Interview. Orlando, FL. 1/25/2008. 27. Pancreatic Cancer, ABC News. Los Angeles, CA. 3/5/2008. 28. Clinical Case Study Challenge and Straight Talk (faculty filming), M2 Communications. NY, NY. 3/8/2008. 29. Pancreatic Cancer, Good Morning America. Los Angeles, CA. March 2008. 30. Significance on Kras Mutation Update (CBCE). XM Satellite Radio at Annual ASCO Meeting 2008. 31. Erbitux Video Shoot. Los Angeles, CA.October 2008. 32. Colorectal Cancer Update curriculum - Research Leader Think Tank. Prognostic and predictive factors in systemic therapy, ongoing translational studies. Radio talk show organized by Dr. Neil Love. Hollywood, CA. 12/23/2009. 33. Optimizing Treatment Regimens for Colorectal Cancer: Hightlights from the 2009 ASCO GI Cancer Annual Meeting(CBCE). Oncology uplugged Interview. San Francisco, CA. 1/17/2009. 34. Colorectal Cancer Awareness Month. Vital Options The Group Room Talk Radio Show. Sherman Oaks, CA. 3/1/2009. 35. Managing treatment side effects for colorectal cancer. Vital Options International The Group Room Cancer Talk Radio Show. Los Angeles, CA. 3/22/2009. 36. Erbitux Media Interview. TV clip that went to air in Australia. Channel 10 News. Melbourne, Australia. 5/17/2009. 37. ECCO/ESMO mCRC Media Debate. Panel1 second speaker (plus rebuttal) and audience. Scene for the lauch of www.TargetMyCancer.com. 9/21-22/2009. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 172 of 173

38. Charla con el Dr. Heinz-Josef Lenz, “Hay una revolucion molecular en cuanto al cancer de colon”. La Capital New Paper. XX Congreso internacional Federacion Lation Americana De Sociedades De Cancerologia. AAOC Asociacion Argentina De Oncoligia Clinica. Mar Del Plata, Argentina. Page 12, 11/10/2011. 39. Buying Time: Funding Cutting Edge Cancer Research and Patient Needs. Inaugural Dinner for The Danny Butler Memorial Fund, Inc. M, NY 10/12/11. 40. Interview in Ankara resulted in multipule publications (May 2012): 5 newspapers, 3 TVs and 37 mostly-rated internet sites made the article, Colon Cancer. Ankara, Turkey, 3/31-4/4/2012. 41. Frankly speaking about colorectal cancer. Workshop, The Wellness Community of the Foothills, Pasadena, CA, 3/26/2012. 42. Vital Options 1:1 interview: Genomics of Metastasis. Chicago, IL, 6/3/2013. 43. Vital Options: produce called Advocacy in Action (AIA), Panel discussion during ASCO. Chicago, IL, 6/3/2013. 44. ECCO/ESMO Bayer Stivarga Virtual Interactive Education Module for Multikinase Inhibition in mCRC and GIST. Netherlands, Amsterdam. 9/30/2013. 45. OncLive Peer Exchange. Treatment of Metastatic Colorectal Cancer: Case Study Reports Outlining Second-line and Later-live Options. SFO, CA. 1/17/2014. 46. Colorectal Cancer. A career dedicated to translational research in colorectal cancer. Future Medicine part of FSG Interview. Published 10.227/CRC.14.43; ISSN 1758- 194X. Colorectal Cancer 4(1), 5-8, 2015. 47. Gastrointestinal Cancer Update 2015 ‹ An Enduring Audio, Print, Podcast, Web and Mobile Interview Series for Medical Oncologists and Other Allied GI Cancer Professionals: 2015 Edition. Radio talk show organized by Dr. Neil Love. Los Angeles, CA. 7/24/15. 48. REAL-LIFE DECISIONS, Clinical Investigators Provide Their Perspectives on Actual Patients with Metastatic Colorectal, Gastric and Pancreatic Cancer. Module 1: Selection and Sequencing of Therapy for Patients with Newly Diagnosed Metastatic Colorectal Cancer (mCRC). Research to Practice (RTP). San Francisco, CA. 1/21/2016. 49. Nintedanib Externale expert filming session with the subject colorectal cancer. 2016 Gastrointestinal Cancers Symposium. Boehringer Ingelheim International gmBh. 1/23/2016. 50. Metastatic Colorectal Cancer: Results of The Mavericc Study. Discusses in German the findings of this phase II study of mFOLFOX6-bevacizumab vs FOLFIRI- bevacizumab with biomarker stratification in patients with mCRC. (Abstract 493).The ASCO Post is pleased to present this special video series of interviews. 1/26/2016.

Educational Material 1. Clinical Update: The role of epidermal growth factor receptor inhibitors in colorectal cancer. Sponsored by American Academy of CME and Clinical Insights. Supported by ImClone and BMS. October 2004-2005. 2. New directions in biological therapy of colorectal cancer. Supported by Genentech BioOncology. Cancer and Abstract Summaries 5(7.) July 2004. 3. Anti-angiogenic Therapy in Oncology. Supported by Genentech BioOncology. Vol. 1, 4 of 11. December 2004. Heinz-Josef Lenz, M.D. Curriculum Vitae USC Department of Medicine Page 173 of 173

4. Timely Issues in EGFR Targeted Therapy. ASCO Review and EGFR Clinical Primer. An interactive CD-ROM and audio CD program. Supported by ImClone and BMS. January 2005. 5. Targeted Therapy in Combination with Chemotherapy in Metastatic Colorectal Cancer. Oncology Consultation 3(1) Jan 2006. Lenz H-J, Giantonio BJ. Physician’s Education Resource, Supported by Genentech BioOncology. 6. New Treatment Paradigms in Colorectal Cancer. Clinical Implementation of Molecular Markers. Iqbal S, Lenz HJ. Supported by Genentech and Sanofi. October 2006. 7. Colorectal Cancer update. Conversations with Oncology Investigators Bridging the Gap between Research and Patient Care. CD-ROM and audio CD program. Lenz H-J, Hoff PH, Hochster H, Hurwitz H. Sponsored by American Academy of CME and Research to Practice. Vol 8/Issue I 2009. 8. Current Developments in the Treatment of Colorectal Cancer. Speakers Lenz HJ, Ryan DP, Bearden DL. Sponsored by CancerCare Connect Education. October 26, 2011. 9. Colorectal Cancer. A career dedicated to translational research in colorectal cancer. Future Medicine part of FSG Interview. Published 10.227/CRC.14.43; ISSN 1758- 194X. Colorectal Cancer 4(1), 5-8, 2015. 10. Gastrointestinal Cancer Update 2015 ‹ An Enduring Audio, Print, Podcast, Web and Mobile Interview Series for Medical Oncologists and Other Allied GI Cancer Professionals: Research to Practice, Fuch C, Lenz HJ, Editor: Love N, GICU 2015 Edition, Audio CD, Vol 6/Issue 1, Dec 2015.