The Institute of Chemistry at 60 Years Anniversary

CHEMISTRY JOURNAL OF MOLDOVA. General, Industrial and Ecological Chemistry. 2019, 14(1), 8-31 ISSN (p) 1857-1727 ISSN (e) 2345-1688 http://cjm.asm.md http://dx.doi.org/10.19261/cjm.2019.349

THE INSTITUTE OF CHEMISTRY AT 60 YEARS ANNIVERSARY. BRIEF HISTORY, ACHIEVEMENTS AND PERSPECTIVES

At the beginning of the 60’s the chemistry Inorganic Chemistry and the Laboratory of in the Republic of Moldova exceeded the Analytical Chemistry of the Moldovan Branch of perimeter of higher education and registered a rise the Academy of Sciences of the USSR. to a new level - the academic level. The first The Institute of Chemistry has witnessed a research group, formed in 1951, was the analytic continuous growth: new laboratories emerged, group connected to the Department of Pedology from existing ones, the Laboratory of Chemistry of the Moldovan Branch of the former USSR of Mineral Resources (1962), Laboratory of Academy of Sciences with the research in the Quantum Chemistry (1964) and Laboratory of field of analytical chemistry and chemistry of Bioinorganic Chemistry (1975), and the coordination compounds. Later, in 1953, the Laboratory of Organic Chemistry (known as the analytical group became a laboratory and in Laboratory of Chemistry of Natural Compounds 1956 the Department of Chemistry was formed. during the foundation of the institute) leads Along with coordination chemistry, the chemistry to the formation of the Laboratory of Organic of natural compounds and organic synthesis Synthesis (1962) [3]. developed. Investigations in the field of chemistry The cornerstones of scientific directions of significantly developed after the formation of the institute were laid down by famous the Departments of Inorganic Chemistry and researchers, members of the Academy of Organic Chemistry of the Moldovan Branch of Sciences, founders of scientific schools in the of the former USSR Academy of Sciences in Republic of Moldova: acad. Antonie Ablov 1956, and even more due to the setting up of the (1905-1978) – school of coordination compounds Institute of Chemistry, which became and still chemistry [1-3,4]; acad. Gheorghe Lazurievski remains, the main centre of chemical research in (1906-1987) – school of organic and bioorganic the republic [1,2]. chemistry [1-3,5], acad. Iurie Lealicov The Institute of Chemistry of the ASM was (1909-1976), organizer and leader of research founded in 1959 (April 15th) on the basis of the related to physical-chemical methods of analysis – Department of Organic Chemistry, and that of school of polarography [1-3,6].

Later, new scientific schools were created, acad. Nicolae Garbalau (1931-2006) [1,3]; those of quantum chemistry – headed by ecological chemistry – headed by acad. Gheorghe acad. Isaak Bersuker [1,3,7,8]; organic, Duca [1,3,11,12]; bioinorganic chemistry – bioorganic chemistry and chemistry of natural headed by acad. Constantin Turta (1940-2015) and physiologically active compounds – headed [1,3,13,14]; and the scientific school in the field by acad. Pavel Vlad (1936-2017) [1,3,9,10]; of chemistry of adsorbents was created by chemistry of coordination, macrocyclic acad. Tudor Lupascu [1,3,15]. and supramolecular compounds – headed by

Acad. Antonie Ablov Acad. Gheorghe Lazurievski Acad. Iurie Lealicov (1905-1978) (1906-1987) (1909-1976)

Acad. Isaak Bersuker Acad. Pavel Vlad Acad. Nicolae Garbalau (1936-2017) (1931-2006)

Acad. Constantin Turta Acad. Gheorghe Duca Acad. Tudor Lupascu (1940-2015)

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During the 60 years the scientific activity of of the Laboratory is Natalia Gorinchoy, doctor this prestigious academic institution has been led of chemistry. up by directors: acad. Antonie Ablov (1959-1961 In 2006, the laboratory was renamed in the and 1965-1975); acad. Gheorghe Lazurievski Laboratory of Quantum Chemistry and Chemical (1961-1965); acad. Pavel Vlad (1975-1995); Kinetics and later, in 2013, the laboratory Nicolae Garbalau (1995-2001); acad. Tudor enlarged by the integration of the Laboratory of Lupascu (2001-2018) and doctor habilitate Magnetic Resonance and Laser Spectroscopy Aculina Aricu (from 2019); deputy (scientific) headed by corresponding member Ion Geru, directors: acad. Isaak Bersuker; dr. Lev Curtev; hence the name of the laboratory was replaced by dr. habilitate Dumitru Batir; acad. Pavel Vlad, the Laboratory of Quantum Chemistry, Chemical dr. habilitate Grigore Junghietu; acad. Nicolae Kinetics and Magnetic Resonance, which Garbalau; dr. habilitate Anatol Dimoglo; currently includes four groups. In 2016 the name dr. habilitate Vladimir Arion; dr. Vasile Lozan; of the laboratory becomes Quantum Chemistry, acad. Tudor Lupascu and dr. habilitate Aculina Catalysis and Physical Methods. Aricu; scientific secretaries: dr. Alexandr Shamshurin; dr. habilitate Dumitru Batir; dr. Dumitru Palade; dr. Valeriu Ropot; dr. Larisa Madan; dr. Raisa Cater and dr. Maria Cocu [3]. At present, the scientific potential of the Institute of Chemistry is represented by 123 scientific researchers, including - three full members of the Academy of Sciences of Moldova, one corresponding member of the Academy of Sciences of Moldova, 10 doctors habilitate and 40 doctors of chemistry. During the years, the Institute of Chemistry of the Academy of Sciences of Moldova passed Dr. habilitate Ivan Ogurtsov through several structural and research-related (1941-2009) reforms. Now the institute includes three scientific centres: the Centre of Physical and Inorganic Chemistry, the Centre of Ecological Chemistry and Environmental Protection and the Centre of Organic and Biological Chemistry. The Centre of Physical and Inorganic Chemistry furnished with modern equipment, was created in 2006 (first named Centre of Physical Chemistry and Nanocomposites) by academician Gheorghe Duca, and includes four laboratories:  The Laboratory of Quantum Chemistry, Catalysis and Physical Methods;  The Laboratory of Coordination Chemistry; Dr. Natalia Gorinchoy  The Laboratory of Physico-Chemical Methods of Research and Analysis;  The Laboratory of Bioinorganic Chemistry and Nanocomposites.

The Laboratory of Quantum Chemistry, Catalysis and Physical Methods was founded in 1964 (under the name of Laboratory of Quantum Chemistry) by academician Isaac Bersuker who led the laboratory for 29 years (1964-1993) [1-3,8]. Professor Ivan Ogurtsov, dr habilitate of physics and mathematics, was the head of the laboratory during 1993-2010. Since 2010 the head Corr. member Ion Geru

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Research in the field of quantum chemistry for a short period (in 2006) the laboratory was was quite significant from the very beginning, guided by corr. member Mihail Revenco [17]. being highly appreciated at the international level. In the same year, 2006, the laboratory was The study of the influence of the electronic renamed in Laboratory of Coordination Chemistry structure on nuclear configurations of polyatomic and was headed by dr. habilitate Ion Bulhac systems and their dynamics led to the elaboration (during years 2006-2016 and 2018- present), and of a new concept in the theory of structure and dr. Diana Dragancea (2015-2018). particularities of polyatomic systems – the concept of vibronic interaction, which resulted in a scientific discovery, this achievement (after official support by ten research institutions of the USSR) was qualified as a “Scientific Discovery” registered in the USSR in 1978 under no. 202: „Явление туннельных расщеплений уровней энергии многоатомных систем в состоянии электронного вырождения” (I. Bersuker „The Phenomenon of Tunneling Splitting of Energy Levels of Polyatomic Systems in Electronic Degenerate States”) [8,16]. The research interests of the Laboratory of Quantum Chemistry, Catalysis and Physical Methods are:  Geometry and electronic structure calculations of molecular systems by Corr. member Mihail Revenco ab initio and semiempirical methods; (1947-2014)  Activation of small molecules through the interaction with coordination compounds of transition metals;  Theory of vibronic interactions;  Study of the “structure-activity” correlation;  Theoretical and experimental studies of reaction mechanisms of redox processes;  Magnetic properties of bi- and trihomonuclear coordination compounds;  ESR in carbon nanotubes and coordination compounds;  NMR in liquids and solids, including the determination of nuclear relaxation times;  Spectroscopic studies and molecular dynamics simulations of the interaction of Dr. habilitate Ion Bulhac biological macromolecules with metal cations.

The Laboratory of Coordination Chemistry is one of the oldest and most representative entities of the institute. The investigations in the field of chemistry of coordination compounds expanded substantially after the formation (in 1956) of the Department of Inorganic Chemistry of the Moldovan Branch of the Academy of Sciences of the USSR. In 1975, the laboratory was called the Laboratory of Chemistry of Coordination Compounds, headed by academician Antonie Ablov (during the years 1959-1978) [1-4]. From 1978 till 2006 the head of the laboratory was academician Nicolae Garbalau, Dr. Diana Dragancea

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The research interests of the laboratory of The Laboratory of Physico-Chemical Coordination Chemistry are: Methods of Research and Analysis has  Synthesis methods, especially template descended from the Laboratory of Analytical synthesis of the mono-, polynuclear and Chemistry, which was founded by academician supramolecular compounds of the transition Iurie Lealicov in 1957 [1-3,6]. Under the metals with organic polyfunctional ligands guidance of professor Lealicov, methods for the based on Schiff bases; analysis of metals in industrial facilities,  basic research in elucidating physical, semiconductors, foodstuffs and environment were chemical, magnetic, catalytic and structural developed. In 1973, dr. Ion Vatamanu was properties of the synthesized compounds; appointed head of the Laboratory of Analytical  applied research of coordination compounds Chemistry (called the Laboratory of as stimulants of the vital activity of some Electrochemical Methods of Investigation for a microorganisms in the biosynthesis of short period), and in 1991 dr. Ludmila Chiriac enzymes, as well as stimulants to increase was elected head of laboratory. Later, the the productivity and drought resistance of laboratory was headed by corresponding member cultivated plants; Mihail Revenco during 1997-2006 [17] and  Synthesis of different metal carboxylates dr. Ion Dranca in the period 2006-2008. In 2006, both of small clusters (mono-, bi-, with the foundation of the Center of Physical trinuclear) and larger cages (from M4 Chemistry and Nanocomposites (now Centre of to M16), as well as coordination polymers Physical and Inorganic Chemistry), the laboratory with the metals such as vanadium, was reorganized and transformed into the chromium, manganese, iron, cobalt, nickel, Laboratory of Physico-Chemical Methods of copper, zinc. Research and Analysis, which at present is headed by dr. habilitate Igor Povar.

Dr. Ludmila Chiriac Dr. Ion Vatamanu (1937-2014) (1937-1993)

Dr. Ion Dranca Dr. habilitate Igor Povar (1945-2012)

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The research interests of the Laboratory of [1,3,14,19,20]. After passing away of academician Physico-Chemical Methods of Research and Turta, dr. Vasile Lozan (2015 - present) was Analysis are: elected as head of laboratory. In 2006, with the  Chemical thermodynamics of complex creation of the Center of Physical Chemistry and chemical equilibria in multicomponent Nanocomposites the laboratory was renamed in heterogeneous systems; Laboratory of Bioinorganic Chemistry and  Developing the theory of buffering capacity Nanocomposites. in multicomponent heterogeneous systems Additionally, in this laboratory, for assessing the effects of pollutants corresponding member Boris Tsukerblat and his remediation in contaminated waters; team developed the scientific direction  Analysis of new organic reagents for the Magnetochemistry and the spectroscopy of the voltamperometric adsorptive accumulation polinuclear coordinative compounds [2,3]. with cathodic or anodic stripping of metals; The research interests of the Laboratory of development of voltamperometric methods Bioinorganic Chemistry and Nanocomposites are: for the analysis of traces of harmful species;  Synthesis of mono- and polynuclear  Testing of certain new organic chelating coordination compounds of transition polyfunctional agents that are used for the elements (nd, 4f) with mono- (H2O, R-Py, adsorptive accumulation of heavy metals on THF, DMAA, etc.) and polydentate ligands the mercury electrode; of Schiff Base type and carboxylic acids;  Development of methods of electrochemical  Investigations of their molecular and accumulation on the carbon fiber electrode crystalline structure (in collaboration with with the surface modified by a monolayer other research groups); of mercury so as to increase the scanning  Deciphering of IR, UV-Vis, Mössbauer, speed, which would significantly shorten NMR, TG and EPR spectra of the the accumulation time and bring closer the synthesized substances; nanomolar detection limit;  Testing of synthesized compounds  The use of spectral methods of structural as single-molecule-magnets (SMM), analysis of organic and inorganic materials. photosensitizers in solar cells with dye sensitizers (CSCs), magnetic nanomaterials The Laboratory of Bioinorganic Chemistry and biologically active compounds. and Nanocomposites was established in 1975 (under the name Laboratory of Bioinorganic The Centre of Ecological Chemistry and Chemistry) by dr. habilitate, professor Dumitru Environmental Protection, created in 2016 and Batir [1-3,18]. The laboratory was designed to headed by academician Tudor Lupascu, includes study coordination compounds with biological three laboratories: activity [1,3]. At the end of 1988, academician  The Laboratory of Ecological Chemistry; Constantin Turta was elected as head of the  The Laboratory of Monitoring of laboratory, giving a new breath to the laboratory Environmental Quality; by implementing progressive methods (at that  The Laboratory of Water Chemistry. time) Nuclear Gamma Resonance Spectroscopy (Mössbauer spectroscopy) and magnetochemistry

Dr. Vasile Lozan Dr. habilitate Dumitru Batir Corr. member Boris Tsukerblat (1927-2014)

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The Laboratory of Ecological Chemistry, 2014 years). In 2015 dr. Raisa Nastas has been was established in 1962 by dr. in chemistry elected as head of the Laboratory of Ecological Nicolae Lobanov, under the name of Laboratory Chemistry. Now the head of the laboratory is of Mineral Resources; and with the purpose dr. Nina Timbaliuc. to research the chemical composition, The research interests of the Laboratory of physicochemical properties of the clay minerals Ecological Chemistry are: and their use in various fields of national  Optimization of the obtaining and economy [1-3]. The laboratory goes into a wider modification technologies of carbonaceous area of concern as the Laboratory of Mineral and mineral adsorbents for practical Resources and Water Chemistry Laboratory, in purposes; 1972, headed by dr. Valeriu Ropot. Later, in  Obtaining and studying of the structure 1991, the laboratory has been modernized and parameters of carbonaceous and mineral coordinated by acad. Tudor Lupascu, who supported catalysts for their use in the reinvigorated it; the laboratory was renamed in catalytic processes of pollutants removal Laboratory of Ecological Chemistry, focusing on from surface and underground waters; the quality of the environment [1,3,11].  Synthesis and study of the new In 2001 acad. Tudor Lupascu was elected polyfunctional materials (including as director of the Institute of Chemistry, thus, the biologically active substances) by chemical Laboratory of Ecological Chemistry was led by and physicochemical methods, useful for dr. habilitate Vasile Rusu (during 2002-2006) and economy, medicine, industry, agriculture by dr. habilitate Mihail Ciobanu (during 2007- and environment.

Dr. Nicolae Lobanov Dr. Valeriu Ropot Dr. habilitate Vasile Rusu (1897-1972) (1934-2002)

Dr. habilitate Mihail Ciobanu Dr. Raisa Nastas Dr. Nina Timbaliuc

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The Laboratory of Monitoring of and Metrology Center of the Academy of Environmental Quality was established in 1978 Sciences of Moldova [21]. In 2007, due to by dr. Burghelea Nicolae under the name of reorganization and optimization, the laboratory Laboratory of Land Geochemistry at the Institute became a part of the Institute of Chemistry. Later, of Geophysics and Geology of the Academy of with the creation of the Center of Ecological Sciences of Moldova [21]. Subsequently, the Chemistry and Environmental Protection in 2016, laboratory was renamed to Laboratory of the laboratory was renamed to Laboratory of Hydrogeochemistry and Laboratory of Water Chemistry. The head of laboratory is Geochemistry. Due to the reorganization and Ms. Mitina Tatiana. optimization of the Academy of Sciences of The laboratory was accredited by the Moldova, which started in 2015, the laboratory National Center of Accreditation of the Republic was transferred at the Institute of Chemistry. With of Moldova (MOLDAC) in 1994, 1997, 2000, the creation of the Center of Ecological Chemistry 2007, 2011, 2015 and 2019. The laboratory and Environmental Protection the laboratory was organizes inter-laboratory tests at the national renamed to Laboratory of Monitoring of level; the object of the analysis is water. Environmental Quality. The head of laboratory is The research interests of the Laboratory of dr. Oleg Bogdevich. Water Chemistry are: Modern methodologies for studying the  Elaboration of new procedures and geochemistry of toxic substances in different improving the existing ones; environmental objects were implemented within  Broadening the spectrum of analyzed the laboratory and now it is accredited according objects and the number of determined to ISO 17025 and can perform the following parameters; analyses of different environmental objects  Improving metrological characteristics of (natural and waste waters, soils, sediments, the procedures; plants):  Evaluation of chemical composition of  determination of toxic organic substances water from different sources (ground, POP, PAH, BTEX; surface, bottled) and its classification  identification of substances in different according to drinking water quality objects by gas chromatography with mass standards. detection;  determination of toxic chemical elements The Centre of Organic and Biological (As, Se, Hg, Pb, Cd, Cu, Zn, Ni, Cr, Al, Chemistry, created in 2016 and headed by Mn, Fe); dr. habilitate Aculina Aricu, includes two  analysis of water quality by standard laboratories: methods.  The Laboratory of Organic Synthesis and Biopharmaceutics; The Laboratory of Water Chemistry was  The Laboratory of Chemistry of Natural founded in 1979, under the name Laboratory of and Biological Active Compounds. Atomic Spectroscopy, as part of the Automation

Dr. Oleg Bogdevich Tatiana Mitina

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The Laboratory of Organic Synthesis and The research interests of the Laboratory of Biopharmaceutics was established in 1962 on the Organic Synthesis and Biopharmaceutics are: initiative of dr. Alexandr Shamshurin, with the  Various aspects of organic and medicinal first name Laboratory of Organic Synthesis. The chemistry; discovery of new catalysts first researches were oriented towards obtaining (metal-mediated and metal-free) for preparations for pests control and of several asymmetric synthesis, mechanistic compounds with attractive properties [1-3]. investigations of reactions which proceed During 1972-1982 the Laboratory of with high levels of regio- and Organic Synthesis, named in 1976 as the stereoselectivity; Laboratory of Chemistry of Preservatives, was  Ionic liquids (including magnetic ones), headed by dr. habilitate Grigore Junghietu which are used as green alternatives to [1,3,22]. In 1984 dr. Miron Krimer took the lead solvents, catalysts, extractors. The of the laboratory, which was then named the laboratory provides a total synthesis of Laboratory of Pesticides Chemistry, and in 1991 biologically active compounds, including named again the Laboratory of Organic Synthesis. natural ones using computer-aided After the decease of the dr. Miron Krimer, the molecular design and study of structure- Laboratory of Organic Synthesis has been headed activity relationships; by dr. habilitate Fliur Macaev [1,3,22]. In 2016,  Development of inexpensive methods for with the creation of the Center of Organic and obtaining of specific co-polymers for Biological Chemistry the laboratory was renamed selective detergent-free isolation of in Laboratory of Organic Synthesis and membrane proteins. Biopharmaceutics.

Dr. Alexandr Shamshurin Dr. Miron Krimer (1909-2003) (1938-1999)

Dr. habilitate Grigore Junghietu Dr. habilitate Fliur Macaev

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The Laboratory of Chemistry of Natural энергии многоатомных систем в состоянии and Biologically Active Compounds was электронного вырождения”). established in 1959 by acad. Gheorghe Lazurievski, under the name of Laboratory of Chemistry of Natural Compounds [1-3,5]. In 1975 the laboratory was divided into two: Laboratory of Chemistry of Steroidal Compounds (headed by dr. in chemistry Petru Ceban and the Laboratory of Chemistry of Isoprenoids (headed by dr. Dumitru Popa). In 1976, both laboratories were reorganized; the first one became the Laboratory of Chemistry of Ethero-oleaginous Plants (headed by acad. Pavel Vlad), and the second one was reprofiled and further led by Dumitru Popa under the name of the Chemistry Laboratory of the Plant Growers and Development Regulators. In 1991 these two laboratories merged into a single research unit - the Laboratory of Chemistry of Terpenoids, headed by acad. Pavel Vlad [1,3,9,10,22,]. In 2010, dr. habilitate Nicon Ungur became the head of the laboratory. In 2016, with the creation Dr. Petru Ceban of the Center of Organic and Biological (1940-2009) Chemistry the laboratory was renamed in Laboratory of Chemistry of Natural and Biologically Active Compounds. The research interests of the Laboratory of Chemistry of Natural and Biologically Active Compounds are:  Targeted synthesis of polyfunctionalized bioactive terpenic compounds;  Elaboration of methods for renewable resources valorisation;  Elaboration of new green methods for the modification of natural products.

Most valuable achievements The results of scientific investigations Dr. Dumitru Popa performed in the frames of the institute are (1927-1997) presented in over 6500 scientific publications, including around 115 collective and individual monographs and thematic selections, over 300 author certificates and patents; over 120 technological elaborations have been implemented into the national economy. Among the most important ones are the following:  Investigations of the influence of electronic structure on the nuclei configuration and molecular dynamics, which were crowned with the “scientific discovery” title „The Phenomenon of Tunneling Splitting of Energy Levels of Polyatomic Systems in Electronic Degenerate States” (author acad. I. Bersuker, registered in the USSR in 1978 under no. 202: „Явление туннельных расщеплений уровней Dr. habilitate Nicon Ungur

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 A new concept was postulated and compound with ferro- or antiferromagnetic developed in the frames of the theory of exchange interactions. molecules and crystals – the theory of vibronic  It was shown that instability of the spin interactions. In the framework of this concept a levels population relative to small structural new approach based on the Jahn-Teller and the distorsions of a trihomonuclear cluster with a Pseudo Jahn-Teller effects has been elaborated for Kramers degeneracy of energy levels did not the interpretation of instability and structural occur, unlike some affirmations made in the changes of molecular systems coordinated to the specialty literature on the existence of this effect. transition metal coordination compounds or Instead, it was shown that such instability was adsorbed on solid surfaces. Applications to only possible in the presence of a constant specific coordination compounds demonstrate the homogeneous electric field. predictive power of the theory and its efficiency  A new method of a virtual time reversal in rationalization of the experimental data on was proposed for testing the time-reversal structural changes in molecular systems due to symmetry. This method has been confirmed their interaction with another system. experimentally for two types of EPR spectra (with  In addition, some progress was made in and without a hyperfine structure) recorded by a understanding the possibility to influence the specific procedure using the modernized EPR planarity of two-dimensional (2D) or quasi 2D spectrometer SE/X-2544. structures through targeted external influences  Chemical-catalytic method of TiO2 (such as excitation, oxidation, reduction, chemical nanotubular particles covered with metal layer substitution, etc.), which means the possibility to (Cu), including the internal surface of nanotubes, manipulate their puckering or buckling. was elaborated, in order to improve the catalytic  In terms of the four-colours groups of properties of the material produced. magnetic symmetry it has been shown that  A new chemical-catalytic method was anomalous magnetic properties of trihomonuclear elaborated for powder particles TiO2 doping with clusters with Kramers degeneracy of energy metals to promote an increase in their catalytic levels, containing ions of Fe(III), Cr(III), Cu(II), activity. The process involves three main V(IV), or Co(II), are caused by structural stages: 1) combined sensibilization-activation; distortions due to the existence of time-reversal 2) application of polymetal layers with the help of symmetry. reducing agent; 3) treatment of the metal layer  Pure CdSe, ZnS and ZnO quantum dots with the weak acid solution. and doped with 3d-ions, which have a broad range  Based on the electron-conformational of applications including water photolysis, solar method the toxicophore identification (TPH) and cells, stable nanometric sources of light, quantitative prediction of the toxicity of a series photocatalysts, chemical sensors, and various of fragrance allergens have been performed. biomedical applications (such as biosensors,  Within the framework of the research bioimaging diagnosis, cancer diagnosis, etc.), topic of “Spectroscopy and molecular dynamics were synthesized using methods of colloidal simulations of the conformation of biological chemistry. It has been established that at relatively macromolecules” were studied the conformation high concentrations of ZnO quantum dots in transitions that human lactoferin underwent as a organic solvents, the excitonic absorption band 1S result of Fe(III)-binding or release. Using small- has a multiplet structure, caused by the self- angle neutron scattering and molecular dynamics organization of quantum points in clusters of simulations it was shown that the binding of different sizes. Fe(III) ions to human lactoferrin depended on  A new method was proposed of spin simultaneous binding of the synergistic anion 2- levels inversion in homonuclear magnetic CO3 , which ensured the formation of a stable dimmers with S1= S2= 1/2 spins by an isomorphic complex compound of diferric human lactoferrin. substitution of one of the ions by a “time-  The concepts and fundamental laws of reversed” one relative to the initial ion. The template synthesis of macrocyclic and method has been generalized for homonuclear supramolecular systems, including highly magnetic dimmers 3dn - 3dn and 4fm - 4fm (1< n< polynuclear clusters were elaborated. Of great 10, 1< m< 14, S1= S2> 1/2). This method allows a importance were the developments in the theory controlled synthesis of binuclear coordinative and practice of the template synthesis of compounds with magnetic properties, when the coordination compounds of transition metals with chemical synthesis result is known in advance: a organic ligands of chelating and macrocyclic type,

18 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 amongst which compounds of practical utility decomposition of μ3-oxo{FeCr2O}acetate, in the were marked out. presence of dodecylamine and oleic acid, used as  Original methods of the synthesis of stabilizing agents, and trichloroacetic acid used as coordination compounds of 3d metals with a solvent had an advanced ordering, namely, a α-dioximes, carboxylic acids and Schiff bases, smectite crystal. aldehydes, ketones, organic amines and other  By using Mössbauer spectroscopy and were developed, which led to the formation of magnetism the nanoparticles of iron oxide in the complexes with novel structures, macrocyclic, form of nanofire were obtained and investigated. supramolecular, excellent biological, catalytic and It has been demonstrated that at room temperature of inhibitory activities. the Mössbauer spectrum exhibits an intense  The dual nature of some ligands was doublet and a low intensity sextet, and revealed, namely: coordination-addition of temperature decrease reveals the dependence of pyridine aldehydes in iron(II) dioximates and the doublet area and sextet on the temperature coordination cyclization of β-diketones in value. It has been clearly established, that in the compounds of cobalt(III). On the cobalt(II) temperature range 110-115 K, the area of the matrix, the synthesis of a 20-dentate macrocyclic doublet and the sextet becomes equal and the ligand was performed, that coordinated 3 or 4 blocking temperature has been estimated in the atoms of cobalt(II) with a highly porous structure, region where the two lines intersect (111 K). which can be used as a storage for small  It has been demonstrated that the molecules of gases such as hydrogen, nitrogen electrocatalytic testing of Ni complexes with and others. bis(4-(p-methoxyphenyl) thiosemicarbazone)-2,4-  Coordination compounds with various butane gave the Faradeic yield at 70% and it was useful properties: polynuclear compounds of determined that one mole of complex catalysed Cr(III) as molecular magnets, catalysts of the production of 9 moles of hydrogen (TON= 9). technological and biotechnological processes, It has been found that Ni complexes with macrocyclic colorants for plastics and synthetic bis (4-(p-methoxyphenyl) thiosemicarbazone)- fibers; new compounds for obtaining extra-pure 2,4-butane and Cu with 2-(2H-benzotriazol-2-yl)- metals, compounds for ion selective electrodes; 4,6-phenol, possessed electrocatalytic properties agents for anticorrosive coating and protection of exhibiting a TON= 18 and 6.5, respectively. metals have been obtained. Using the obtained  Synthesis and multilateral study of porous compounds the following preparations were transition metal coordination compounds based on created: Trifenamid, Coditiaz, Cobamid, mixture ligands and biphenyls containing Compozit, Conimid, Compozit-plus, Fludisec, carboxyl groups, and/or donor nitrogen atoms as Polyel, Virinil, Galmet, Gajazot and others, which potentials sorbents for small molecules were can be used to develop new advanced performed. technologies or to improve the existing ones in  The quantitative basis for the theory of agriculture and microbiology. buffering properties for multicomponent  Investigations related to coordination heterogeneous buffer systems has been developed. compounds of biometals (Fe, Co, Mn, Cu, Zn, Ni) Mathematical equations were derived for with α-dioximes, Schiff bases and carboxylic estimating the quantitative buffering capacity acids, including amino acids were performed. The towards mineral phase components. It has been electronic structures of iron(II) and (III) established that the buffer capacities of the dioximates, of homo- and heteronuclear clusters components were reciprocally proportional. containing iron were determined, allowing a more  Determination of toxic metals in water, adequate interpretation of spectra of such soil, etc., catalytic currents and adsorption compounds. phenomena of voltammetry species, the stripping  Carboxy dysprosium cluster adsorption polarography, the chemical and {[Dy(α−C4H3OCOO)(µ−(α−C4H3O electrochemical activation of carbon fibre COO))2(H2O)3]}n exhibits a slow magnetic microelectrodes were used. Methods of analysis relaxation at 10 K; two Dy ions with different of trace metals in electronic materials and surroundings behave as single-ion magnets (SIM) semiconductors were developed. Also, the with a different activation energy, Ueff= 80.5 K behaviour of some organic polydentate and and 32.4 K. Continuous cooling allows to reach polyfunctional reagents of oxoacids, metalocrome the quantum tunneling regime. indicators, triazine dyes, thiosemicarbazones in  Nanoparticles (NPs, d= 11±3 nm) of the complex forming reactions is under study. The iron-chromium oxide prepared by thermal impact of these interactions on the selectivity and

19 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 sensitivity of the methods of electrochemical prepared. Presently, the syntheses of nitrogen analysis of heavy metals was specified. Effective containing drimanes are performed. methods were developed for the analysis of such  Systematic studies were performed in the metals as Pb, Cu, Cd, Fe, Ni, Zn and Mo, in field of terpene cyclizations with superacids. It foodstuffs and the environment. was established that on superacidic treatment  The quanto-chemical computation of the labdanic compounds give tricyclic isoagatanic system catalyst – activator – oxidant, was diterpenes in high yields. Natural compounds of performed for the first time, which allowed a spongian series were synthesized. The reaction of deeper understanding of the catalytic process superacidic cyclization of alcohols, their acetates, mechanism. of acids and their esters of C10-C25 series was  The investigation of two classes of natural studied and it was found that the reaction was organic compounds: alkaloids and terpenoids chemo- and structural-selective and stereospecific constituted the main orientation of research at the and gave cyclic compounds in high yields. The initial stage in chemistry of natural compounds. same regularities of the superacidic cyclization This chemical study has been performed on a reaction were observed in the case of homo- and large number of spontaneous and cultivated bishomo- terpenic derivatives. plants, as well as on wastes remaining on the  New efficient methods for the synthesis of processing of vegetal raw material, both of drimenoic and homofarnesoic acids have been theoretic and practical value. Over 750 species of elaborated. They have been coupled with amines local plants were tested for alkaloids presence. of pirimidine, pirazine, 1,2,4-triazole and  Research related to the chemistry of carbazole structures. terpenoids started with the study of compounds  Guanidinic derivatives of isolated from vegetal wastes, generated during the homofarnesenoic acid, as well as of distillation of essential oils from clary sage, 14,15-dinorabd-8(9)-en-13-amine have been lavender, mint, etc. A quite accessible compound synthesized for the first time. Evaluation of has been found – sclareol, a diol isolated from the antiproliferative and cytotoxic activities of these sage Salvia sclarea L. The method of their compounds demonstrated that the investigated isolation has been elaborated, and their guanidines show a very high activity against derivatives have been obtained. MRC5 human pulmonary fibroplasts and colon  Special attention was paid to the study of adenocarcinoma cells. stereochemistry of a series of labdanic  The coupling-heterocyclization reaction diterpenoids. The absolute configuration at the involving the hydrazide of 8α-hidroxi-11- chiralic C13 centre was established for various homodrimanic acid and tetramethyltiurame diterpenoids: sclareol, labdanolic acid, manoyl disulfide was studied. The formation of two oxides and their derivatives. bioactive compounds has been achieved:  A large number of oxidic odorants with homodrimanic oxadiazole and tiadiazole. tetrahydrofuranic and tetrahydropyranic decalinic Antimicrobial testing revealed that the and hydrindanic structures belonging to the synthesized oxadiazoles possessed significant norlabdanic series were synthesized. antifungal and antibacterial activities against five  A new logico-structural and electron- fungal strains, as well as against gramm-negative topological theory was proposed revealing the and gramm-positive bacteria. dependence of amber odour on the structure of  New efficient free radical methods for the compounds. Subsequently, the same approach synthesis of a series of ent-kauranic derivatives was used to explain the dependence of musk have been elaborated and their cytotoxic activity odour on the structure of compounds with this has been investigated. odour.  Efficient synthetic methods have been  On the basis of norambreinolide, a series elaborated for the synthesis of natural tetracyclic of derivatives with rearranged carbonic skeleton diterpenoids with ent-kauranic skeleton with were synthesized, several of which with a strong functional groups in cycles C and D, including amber fragrance. oxygenated and halogenated moieties. Their high  The cleavage products of a series of anti-HIV and antitumor activity has been accessible labdane diterpenoids have been demonstrated. investigated. Original methods for the preparation  A new synthetic pathway has been of a large number of drimanic sesquiterpenoids reported to access nor-scalarnic sesterterpenoids and norlabdanic derivatives have been elaborated. functionalized at C12. This method opened a new A group of drimanic diols and tetraols were perspective for the synthesis of a whole sub-class

20 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 of natural bioactive scalaranic sesterterpenoids synthesis of 5-aryl-2-thio-1,3,4-oxadiazoles was which are currently hardly available. performed with several of the synthesized  The synthesis of functionalized compounds showing high anti-tuberculosis diterpenoids of ent-isocopalic structure which activity. showed selective antitumor activity has been  The syntheses of the natural antifeedant performed. cryptomerlone and monoterpene carvone were  Advanced studies have been conducted on elaborated for the first time. It has been found that the elaboration of synthetic pathways towards a an effective method for the preparation of whole series of perhidrindanic and ent-halimanic common precursor of above compounds is the compounds. electrochemical anode oxidation of α-pinene. It  In the field of organic synthesis, at the was found that chiral chlorohydrins or quinolines beginning, the investigations were oriented may be selectively obtained from the pinonic acid. towards the synthesis of bioactive compounds for  A number of heterocyclic derivatives of use in winemaking and veterinary, with 2,2-dimethylcyclobutane, some of which possess antibacterial, antiviral, antifungal, antihelminthic the anti-HIV-1 activity were synthesized. aproperties.  General methods for stereoselective  The synthesis and application of synthesis of optically active biologically active pheromones for plant protection against pests was pyretroids and clerodane compounds and their developed. The isolation, characterization and precursors were developed from (+)-3-carene and synthesis of the following attractants have been of (-)- and (+)-carvones. accomplished: disparliur (forest pests Porthetria  A new method for the preparation of dispar), propiliur (white American butterfly clerodane polyfunctional diterpenoids was Hyphantria cunea), ghipliur (queen-bee Apis developed. Stereoselective syntheses of natural mellifera L.). biologically active diterpenoids – antifeedants  The synthesis and investigation of Lupuline C and (-)-dihydroclerodine from nitrogen-containing heterocycles were started. (-)-R-carvone were performed. It was found that Investigations related to the compounds with the nanosized catalytic system (~5-6 nm of preserving properties for fruits, juices, beer, γ-Fe2O3/CuO) works as an efficient organic phase essential oils, and animal food were carried out. catalyst (~0.02 mol%) in the one-pot three For these purposes, the hydroxamic acids were components Biginelli synthesis. Previously studied, as well as quinoline derivatives and unknown P*-mono, P*,N- and P*,N*-bidentate mixed anhydrides of several acids. Preservatives phosphite ligands based on carenes and pinenes for rose petals and fish spawn were proposed. were found to be successful ligands for the An active preservative for refreshing drinks - Pd-catalysed allylation of 1,3-diphenylallyl JUGLONE was proposed. Studies in the field of acetate with (Pr)2NH, (CH2)4NH, PhCH2NH2, indole derivatives, isatine and quinoline were CH2(CO2Me)2 and 4-Me-C6H4SO2Na. The carried out. enantioselectivity reached 99% ee, being the best  A new synthetic method and technology result among all known optically active for obtaining of the systemic fungicide Tilt phosphites. (PROPICONAZOL) were developed, including  In the framework of the investigation of synthesis of its structural components: the mineral resources of the Republic of Moldova 2,4-dichloroacetophenones, 1,2-pentandiol and mineral adsorbents (bentonites, illites, etc.) were 1,2,4-triazol, and alkylation reaction of applied in wastewater purification technology 1,2,4-triazoles. from the production of dairy and meat products,  New catalysts (metal-containing and also to purify the mash obtained when producing metal-free) for asymmetric synthesis and cognac, to clarify (refining) sunflower oil. mechanistic investigations of reactions that Extensive studies were performed in order to proceed with high levels of regio- and improve sorptional and catalytic properties of stereoselectivity were obtained. bentonites, resulting in the elucidation of changes  For the first time, it was demonstrated that in the crystal lattice of montmorillonite, changes using one-pot reaction it is possible to transform in surface chemistry, and cation exchange available chalcones to very stable pyrazolines capacity. with a high yield. It was shown that derivatives of  The synthesis of a new class of adsorbents acetophenones with pyrazoline and oxindole from clay minerals (pillared clays) has been fragments possess antidepressant activity. Based performed. Pillared clays (PILCs) have larger on hydrazides of benzoic and salicylic acids, the pores compared with ordinary zeolites. Such

21 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 materials have been obtained by pillaring of clay carried out have resulted in the development and minerals, particularly montmorillonite, with patenting of five compositions of building oligomeric species by hydrolysis of polyvalent materials on the basis of limestone as the main cations, especially of aluminium ions. They are component. The obtained building materials are characterized by a high thermal stability and large cheaper and their quality is comparable to that of surface area. the imported products.  The influence of surface chemistry of  Another technology that was developed PILCs obtained from Ascangel montmorillonite and applied into practice is the treatment of (Georgia) and Larguta bentonite (R. Moldova) in wastewater from the dyeing processes in textile catalytic processes was evaluated. The tests factories. The purified wastewater can be returned carried out show that intercalated adsorbents in the technological process being economically obtained from Larguta bentonite (R. Moldova) advantageous. have real prospects for use in practice as solid  The procedures to improve drinking water acid catalysts for organic synthesis and for the quality, i.e. replacement of the chlorination production of biofuel from vegetable oils. process by the ozonation and the process of  The quality of water from the main water adsorption of POPs traces, based on activated resources of the Republic of Moldova (Danube, carbons obtained from fruit stones and nut shells Dniester, Prut, Raut, Bic Rivers, Dubasari, were evaluated. Use of the activated carbons Costesti-Stanca, Cuciurgan, Ghidighici, Taraclia, allowed obtaining high-quality drinking water. Ialpug, Cahul reservoirs, etc.) was investigated.  Technologies for the purification of Research results allowed to elucidate the groundwater containing hydrogen sulphide and processes and mechanisms of interaction between sulphides have been developed. A broad spectrum chemical components in water systems, of modified carbonaceous and mineral adsorbents depending on various factors, such as (modified with Fe, Cu, Mn, etc.) has been tested temperature, reaction medium, dissolved oxygen for removal of sulphide ions from water. concentration, anthropogenic pressing, turbidity, Comparative analysis of adsorbents highlights the water flow velocity, ionic strength, etc. The performance of carbonaceous adsorbents obtained processes and mechanisms of immobilization, by impregnation with copper (II) ions and mineral migration and transformation of heavy metals, adsorbents modified with manganese ions, being organic and inorganic nitrogen and phosphorus recommended for practical purposes to remove compounds in water - particulate materials - hydrogen sulphide from natural waters. Using the bottom sediments in the main water bodies of the copper modified carbonaceous adsorbents allows R. Moldova were also studied. oxidizing sulphide ions to thiosulphate ions,  With the purpose to improve the sulphite and sulphate, avoiding the formation of wastewater treatment technologies, the colloidal sulphur. Field tests of copper composition of wastewaters from the main impregnated carbonaceous adsorbents for removal economic units of Republic of Moldova has been of hydrogen sulphide from underground waters studied. The processes and mechanisms of have been performed in town Hincesti coagulation, decanting, flotation, oxidation, (R. Moldova). The results showed that the adsorption of organic and inorganic pollutants recommended process ensures 100% efficiency detected in wastewater on carbonaceous and for the removal of hydrogen sulphide from mineral adsorbents were investigated. The underground water. obtained results were used to develop  Technological processes for removing of technologies for purifying wastewater from the iron, manganese, strontium ions, ammonia, etc. food industry and textile enterprises. The most (having concentrations often exceeding the relevant achievements in this area are represented permissible limits) have been developed and by the technologies that are developed and patented. Field tests of the technological implemented at Wine and Brandies Factory from processes for their removal have been performed the Balti city, which contribute to purifying the in village Sculeni, district Ungheni, R. Moldova. wastewater after wine distillation. Application of Ecological and health expertise confirms that the this technology allows to obtain tartaric acid and proposed technology is efficient and the treated also to apply sediments formed by sedimentation water meets the ecological and sanitary norms of the mineral adsorbents for building materials. regarding the quality of drinking water.  Wastes from the limestone mines near the  In the framework of the development of municipality of Chisinau are a matter of concern the technologies for obtaining the activated to the scientists of the institute. Research that was carbons from fruit stones, grape seeds and nut

A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 shells, investigations have resulted in the with the requirements of the EU Water development and patenting of procedures to Framework Directive. obtain the activated carbons by physicochemical,  The analysis of the results of the chemical chemical and mixed activation methods. Analyses composition of natural waters (from Republic of have shown that quality indices of autochthonous Moldova) reveal that in 70% of the cases, the activated carbons are comparable with those of studied water collected from different wells did commercial ones. Testing of autochthonous not meet the requirements for drinking water activated carbons for treatment of water and quality on one or more parameters. The wastewater, and for detoxification of the human groundwater had an increased content of ammonia organism demonstrated that local activated and ammonium ions, hydrogen sulphide and carbons are appropriate for solving current sulphide ions, sodium ions, iron, manganese, problems, namely for protection of the increased oxidation values, as well as increased environment and human health. calcium and magnesium levels.  Microbiological, pharmacological, and  Advanced methods have been developed toxicological research, have shown that the Enoxil for the determination of chlorine, sulphate and preparation is not toxic and exhibit pronounced nitrate ions in coloured waters to solve problems antifungal and antibacterial properties. On the related to the monitoring of the quality of the basis of Enoxil, new pharmaceutical preparations waters. Enoxil-M and Enoxil-A were developed and tested All scientific results with potential under clinical and field conditions. Field testing application are protected by patents and showed that Enoxil-A preparation enhanced appreciated with medals at national and agricultural crops resistance. Clinical testing of international exhibitions of inventions: VDNKh in the pharmaceutical preparation Enoxil-M, MSSR and USSR; State Agency on Intellectual produced by the local company "Farmaco" LTD, property, INFO INVENT (AGEPI, R. Moldova); has shown its beneficial activity in the treatment “EUREKA” (Brussels, Belgium); INVENTIONS of diseases caused by fungi and bacteria, in (Geneva, Switzerland); INVENTICA, PRO particular, in healing of wounds caused by INVENT EUROINVENT INVENT INVEST thermal and surgical injury. (Bucharest, Iasi, Cluj Napoca, Timisoara  Experimental batches of compositions Romania); International Invention Show (creams, ointments, gels) based on usage of the „40 INOVA”, „TESLA Fest” (Osijek, Karlovac, Enoxil were prepared and tested under clinical Novi Cad, Croatia); „IVIS 2016” (Warsaw, conditions. Poland); 10th International Exhibition of  Laboratory analysis of industrial waste Inventions & 3rd World Invention and Innovation stocks and obsolete chemicals, accumulated Forum (China) etc. historically at industrial enterprises has been Among the most recent innovations that done. Agricultural soil and groundwater were have been implemented into the national economy studied with the purpose of toxic substances or are proposed for implementation we can determination and risk assessment. The mention (http://chem.asm.md/): methodology for environmental and population  Aromatizers (flavour compositions) and health risk assessment has been proposed, sauces for the tobacco industry which allow the including the impact of human activities and production of high quality tobacco products with hazardous geological processes (erosion and an intense aroma of high-quality tobacco, fine and landslides). pleasant taste. Their composition is almost  The geological conditions of the storage identical to the composition of the compounds of radioactive substances in the Chisinau extracted from tobacco. The process of production municipality were evaluated. The conceptual of aromatizers utilizes local raw material – wastes model of risk estimation for the given lot was obtained after treatment of ethero-oileaginous developed with the slope stability calculation and plants and other natural local products. Flavours taking into account various scenarios of climate compositions have been implemented at the change. Migration of toxic substances into the Tobacco Plant (SA Tutun-CTC, Chisinau, environment has been investigated on the basis of R. Moldova). specific pollution sources.  New materials for buildings surfaces  Groundwater characterization and quality plastering, on the basis of local raw material assessment has been performed within the (gypsum, lime, limestone flour and other three management of aquatic resources in accordance micro-constituents) were implemented at SA Monolit (R. Moldova).

23 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31

 The technology for the production of implemented at Bakery Factory (Tiraspol, activated carbons from local raw material (wood, R. Moldova). nut shells, peaches, plums and apricots stones) is  Underground water treatment implemented at LTD Ecosorbent (Stefan Voda, technologies for the removal of iron ions, bivalent R. Moldova). manganese, humic substances, hydrogen sulphide  The ecological technology for the and sulphides were tested in field conditions at recycling of plastic wastes (integral processing of Sculeni (Ungheni, R. Moldova) and Hincesti plastic wastes by mechanochemical processes, (R. Moldova). with the obtaining of new products) was  Catalysts for the solidification of implemented at LTD UISPAC (Chisinau, epoxydic resins, on the basis of polynuclear R. Moldova). compounds of chromium, which allow obtaining  The technology of using waste in the dielectric materials with optimal parameters for glass processing industry consists in the use of the microelectronics, have been implemented at the sediment formed after the neutralization of Moldavizolit Factory (Tiraspol, R. Moldova). glass glazing waste and was implemented at LTD  Catalysts for the coloring of cotton Luxochim (R. Moldova). fabrics by the bathing method; catalysts based on  The technological process for glaucine coordinate compounds allow to save energy and isolation from the medicinal plant Glaucium to obtain the materials with more intense, stable Flavium Grantz was implemented at LTD colors. Catalysts were implemented at Tiraspol Labormed (R. Moldova). Textile Factory – LTD Tira-Tex (Tiraspol, R.  The technology for the production of Moldova), as well as at Textile Factories abroad: pressed bricks based on Portland cement and Moscow, Ivanovo, Kalinin (now Tver) and local mineral materials has been implemented at Yartsevo (Russian Federation), Ternopol (now LTD Odgon (Basarabeasca, R. Moldova). Ternopil, Ukraine).  The technology of organic sludge  The selective catalyst for obtaining processing in an ecological product for Juglone, has allowed the development of a agriculture has been implemented at SA Apa simplified, non-polluting and less costly Canal (Chisinau, R. Moldova). technology. The method was implemented at the  The technology for the Biochemical Plant (Ungheni, R. Moldova), and treatment/potabilization of groundwater has been can be applied for the preparation of antiseptic drugs (Nucina and others).

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 Juglone has been proposed as an active the SUMF "Nicolae Testemitanu" and Tiraspol preservative for soft drinks and has been Clinical Hospital (Republic of Moldova). introduced into the production cycle at Ostankino  The preparation Mobipan – Brewery (Moscow, Russian Federation). antihypertensive agent developed for treatment of  Catalysts - stabilizers for polyurethane cardiovascular diseases that has passed the compositions. The proposed substances KDMF-1 preclinical tests at the Laboratory of Preclinical and KDFF-9 in the polyurethane compositions and Clinical Evaluation of Medicines of the simultaneously perform the function of catalyst Medical Center of the SUMF "Nicolae and stabilizer, do not carry a pronounced selective Testemitanu" (Republic of Moldova). character while at the same time improve the  New compounds of natural and synthetic qualities of the polyurethanic composition, the origin with antituberculosis properties, viability of the composition, its physical- derivatives of chalcone, triazole, oxodiazole and mechanical and adhesion characteristics, raise the β-carbolines have passed the preclinical tests at resistance of the composition against the Laboratory of Preclinical and Clinical thermooxidative destruction. The preparation is of Evaluation of Medicines of the Medical Center of interest to the chemical industry of the Russian the SUMF "Nicolae Testemitanu" and the Federation, Romania, Ukraine, etc. Laboratory of Microbiology and Morphology of  The preparation Enoxil-A can be used to the Institute of Phthisiopneumology (Republic of increase plants resistance against root rot and gray Moldova), Department of Pharmaceutical rot, was tested in field conditions on experimental Chemistry, Aristotle University of Thessaloniki grounds at Research Institute for Field Cultures (Greece), Liverpool John Moores University, "Selection" and of the National Institute for (Liverpool, UK), Institute of Biomedical Viticulture and Wine-making. Chemistry, Russian Academy of Medicinal  The preparation Enoxil-M for the Science (Moscow, Russia), Institute of treatment against bacteria and fungi in the process Pharmacology, Russian Academy of Medicinal of regeneration of thermal, physical and chemical Science, (Moscow, Russia), Southern Research wounds, in the treatment of postoperative wounds. Institute (Birmingham, AL, USA), “Carol Davila” On the basis of the preparation Enoxil-M were University of Medicine and Pharmacy, obtained medicinal products produced at Pharmacology and Clinical Pharmacy Department SA Farmaco and were tested in four Republican (Bucharest, Romania). Pharmaceutical forms for clinics in Chisinau (the Dermato-venerological these compounds have been developed; the acute Dispensary, the Oncological Institute, the and chronic toxicity and bioavailability were Republican Children's Hospital E. Cotaga, the tested. Republican Thermal Damage Center)  The preparation Gajazot with (R. Moldova). antichlorosis properties for vines. The 0.3%  Dental preparations Fenglicol and solution of this compound exhibits antichlorosis Fencarin, obtained from fennel with ingredients properties in vines and fruit-trees. Treatment of such as eucalyptus oil, glycerin etc. The vineyards, affected by chlorosis, with this preparations are useful in treating gingivitis, preparation completely restores their production periodontitis, and other inflammation affections of potential. the oral cavity. Fenglicol and Fencarin have  The preparation Virinil – growth passed the preclinical tests at the Laboratory of stimulator for vine grafting, roses and Preclinical and Clinical Evaluation of Medicines strawberries rooting. Virinil significantly of the Medical Center and Faculty of Stomatology increases the outcome of the grafted slips. The of the SUMF "Nicolae Testemitanu" (Republic of preparation Virinil has been implemented at SA Moldova). Codru Nord (Balti, R. Moldova).  The preparation Salvit-1 - can be used  The preparations Coditiaz, Cobamid, for treatment of affections related to the Compozit, Conimid, Trifenamid with growth locomotor system and to the peripheral bone stimulator properties and growth of crop plants. system (radiculitis, osteochondrosis etc.). Salvit-1  The preparations Trifeden and represents a vegetal mass of Salvia, processed Difecoden – stimulators and regulators of growth, according to a certain technology, and can be development and productivity of corn. attributed to ecologically pure medicinal  The preparation Propiconazol (Tilt) with preparations. Salvit-1 has passed the preclinical antifungal properties, which can be used against tests at the Laboratory of Preclinical and Clinical various fungal affections of cereals. A new Evaluation of Medicines of the Medical Center, of technology has been developed for its production,

25 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 including synthesis of its structural components: 2009, 345 p. (in Romanian). (Academicianul 2,4-dichloroacetophenones, 1,2-pentandiol and Pavel Vlad - savant ilustru şi promotor tenace al 1,2,4-triazol, and alkylation reaction of 1,2,4- ştiinţei. Chişinău, Tipografia AŞM, 2009, 345 p.) triazoles.  Purice I.; Cazac T.; Caşcaval I. Chemistry  The preparation Decametrine with anti- of public foods products. Chisinau, MOLDCOOP, insecticide properties, which can be used for the 2009, 136 p. (Purice I., Cazac T.; Caşcaval I. protection of agricultural plants and animals Chimia produselor alimentaţiei publice. Chişinău, against insects. MOLDCOOP, 2009, 136 p.)  The preparation Codiclogu, new anti-  Lupascu T.; Duca Gh.; Lupascu G. Enoxil coccidiosis preparation practically completely - ecological preparation for plant protection. destroys coccidia in rabbits. It can be used for the Chisinau, Publishing house of ASM, 2010, 144 p. prophylaxis and treatment of animals against ISBN 978-9975-62-274-5. (in Romanian). intestinal intercellular parasites. (Lupaşcu Tudor; Duca Gheorghe; Lupaşcu  The preparation Codimez, exhibits major Galina. Enoxil - preparat ecologic pentru therapeutic activity in pesticide-poisoned animals. protecţia plantelor. Chişinău, Tipografia AŞM, This kind of preparations are not known. 2010, 144 p. ISBN 978-9975-62-274-5)  The preparation Chetizal - a  Aricu A. Ed. Researcher and prestigious psychotropic synthetic preparation from the group manager: Professor Tudor Lupascu at the 60 of antidepressants. years. Homage volume. Chisinau, Publishing  The new preparation Setremed with house of AŞM, 2010, 296 p. (in Romanian). (Red. anticancer properties is effective against cervical şt. dr. A. Arîcu. Cercetător şi manager de tumors (CCU-5, 80-90%), B-15 melanoma (80%), prestigiu: profesorul Tudor Lupaşcu la 60 de ani. Luis lung tumor (70-80%) and others. The Volum omagial. Chişinău,Tipografia AŞM, 2010, preparation Setremed has synergic effect on joint 296 p. ISBN 978-9975-9690-4-8) administration with sarcolicin, cisplatin (DDP)  Lupascu T. Ed. Professor Constantin and local irradiation. The preparation has Turta. The path of knowledge and scientific successfully passed the first phase of clinical results. Chisinau, Publishing house of ASM, testing in oncological centers in the Republic of 2010, 328 p. ISBN 978-9975-62-277-6. Moldova and the Russian Federation and was (in Romanian). (Coordonator: dr. hab., prof. proposed for the second phase of clinical testing Lupașcu Tudor. Profesorul Constantin Turtă. in the Oncological Institute of the Republic of Drumul cunoştinţelor şi rezultatelor ştiinţifice. Moldova. Chişinău, Tipografia AŞM, 2010, 328 p. ISBN 978-9975-62-277-6.) Scientific results were summarized in over  Geru I. Ed. Transactions on metrology 120 books, monographs and chapters, published and analytical methods of research. Chisinau, by national and international publishers Publishing house of AŞM, 2010, 283 p. (e.g. Stiinta, Publishing house of ASM, Khimia, ISBN 978-9975-62-276-9. Springer Science-Business media B.V., John  Lupascu T.; Duca Gh.; Goncear V. Enoxil Wiley & Sons, Springer International Publishing, – ecological preparation for human health. Palmarium Academic publishing, Publishing Chisinau, Publishing house of ASM, 2011, 256 p. house of Romanian Academy, Springer Nature ISBN 978-9975-62-304-9. (in Romanian). Switzerland, Atta-ur-Rahman, Elsevier, Wiley (Lupaşcu Tudor; Duca Gheorghe; Goncear VCH, N.Y., Nova Science Publishers, INC, N.Y. Veaceslav. Enoxil – preparat ecologic pentru etc.); the list for the 50 years is presented on the sănatatea omului. Chişinău, Tipografia AŞM, institute web page (http://chem.asm.md/) [1]; the 2011, 256 p. ISBN 978-9975-62-304-9) list for the last 10 years is presented below.  Shofransky Z.; Shofransky V. Traditional Books, monographs, chapters Romanian chromatics. Technology, ways of  Bersuker I. Electronic Structure and acquiring and functionality of natural dyes in Properties of Transition Metal Compounds. Carpatho-Danubian-Pontic space. Bucuresti: Introduction to the Theory. John Wiley & Sons, Etnologic Publishing house, 2012, 454 p. 2009, 760 p. ISBN 978-9738920-37-8. (in Romanian).  Duca Gh. Contributions to knowledge (Şofransky Zinaida; Şofransky Valentin. society. Chisinau, Publ. “Stiinta”, 2009, 280 p. Cromatica tradițională românească. Tehnologia,  Aricu A. Ed. Academician Pavel Vlad - modalitățile de dobîndire și funcționalitate a an illustrious scientist and tenacious promoter of coloranților naturali în spațiul carpato- science. Chisinau, Publishing house of ASM, danubiano-pontic. Red. șt.: dr. hab. în istorie

26 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31

V. Dergaciov, dr. hab. în chimie T. Lupaşcu.  Vlad P.F.; Macaev F.Z.; Arîcu A.N. Bucureşti, Editura Etnologică, 2012, 454 p.) Introductory course on the stereochemistry of  Geru I.; Shter D. Resonance Effects of organic compounds. Chisinau, Publishing house Excitons and Electrons. Basics and Applications. of ASM, 2014, 200 p. (in Romanian). (Vlad P.F.; Eds. SPRINGER Science-Business media B.V. Macaev F.Z.; Arîcu A.N. Curs întroductiv al 2013, 283 p. DOI: 10.1007/978-3-642-35807-4 stereochimiei compușilor organici. Chișinău,  Simeonov L.; Macaev F.; Simeonova, B. Tipografia AȘM, 2014, 200 p. ISBN 978-9975- Environmental Security Assessment and 62-360-5) Management of Obsolete Pesticides in Southeast  Macaev F.Z.; Junghietu G.I. Chemistry of Europe. Eds. SPRINGER Science-Business media drugs. Palmarium Academic publishing, B.V. 2013, 475 p. ISBN 978-94-007-6460-6. Saarbrűcken, Deutscland. 2015, 585 p. DOI: 10.1007/978-94-007-6461-3 (in Russian). (Макаев Ф.З.; Жунгиету Г.И.  Geru I. Highlights on time axis. Chisinau, Химия лекарственных средств. Palmarium Publishing house of ASM, 2013, 276 p. ISBN Academic publishing, Saarbrűcken, Deutscland. 978-9975-62-335-3. (in Romanian). (Geru Ion. 2015, 585 c. ISBN 978-3-659-60059-3) Repere pe axa timpului. Chişinău, Tipografia  Filip G.; Ciocarlan A. Practical work on AŞM, 2013, 276 p. ISBN 978-9975-62-335-3) organic chemistry. Part I. Chisinau, UST, 2015,  Duca Gh. Management of Water Quality 80 p. (in Romanian). (Filip G.; Ciocârlan A. in Moldova. Ed. Duca Gh. Springer International Lucrări practice la chimia organică. Partea I. Publishing, Switzerland, 2014, Series: Water Chișinău, UnST, 2015, 80 p.) Science and Technology Library, 241 p.  Filip G.; Ciocarlan A. Practical work on DOI: 10.1007/978-3-319-02708-1 organic chemistry. Part II. Chisinau, UST, 2016,  Povar I.; Spinu, O. Thermodynamics of 80 p. (in Romanian). (Filip G.; Ciocârlan A. complex chemical equilibria in multicomponent Lucrări practice la chimia organică. Partea II, heterogeneous systems. Chisinau, Publishing Chisinau, UnST, 2016, 80 p.) house of AŞM, 2014, 452 p. (in Romanian).  Covaliov V.; Duca Gh.; Covaliova O. (Povar I.; Spînu, O. Termodinamica echilibrelor Green energy: innovative ecobiotechnology and chimice complexe în sisteme eterogene combined reactors. Anthology of inventions. multicomponente. Chişinău, Tipografia AŞM, Chisinau, CEP USM, 2017, 504 p. (in Russian). 2014, 452 p. ISBN 978-9975-62-382-7) (Ковалев В.; Дука Г.; Ковалева О. Зеленая  Povar I.; Lupascu T.; Leah T.; Andries энергия: инновационные экобиотехнологии и S.; Filipciuc V. Natural and anthropogenic комбинированные реакторы. Антология factors influencing the quality of soils and water изобретений. Кишинэу, CEP USM, 2017, 504 c. resources of the Republic of Moldova. Chisinau, ISBN 978-9975-71-902-5.0) Publishing house of ASM, 2014, 268 p.  Dragancea D. Supramolecular chemistry. (in Russian). (Повар И.; Лупашку Т.; Лях Т.; Lesson course, master. Chisinau, 2018, 75 p. Андриеш С.; Филипчук В. Природные и (in Romanian). (Dragancea Diana. Chimie антропогенные факторы воздействия на supramoleculară. Curs de lecții, masterat. качество почв и водных ресурсов Республики Chișinău, 2018, 75 p.) Молдова. Кишинэу, Типография АН Молдовы,  Duca Gh.; Macaev F. Compounds and 2014, 268 с. ISBN 978-9975-62-383-4.) materials for drug development and biomedical  Batir D. Message to light: applications. București, Publishing house of Miniencyclopedia or the values of chemistry and Romanian Academy, ”Istros a Muzeului Brailei humanity. Chisinau, Publishing house of ASM, ”Carol I”, 2018, 307 p. 2014, 356 p. (in Romanian). (Batîr D. Solie către  Geru I.I. Time-Reversal Symmetry. Seven lumină: Minienciclopedie sau despre valorile Time-Reversal Operators for Spin Containing chimiei şi ale omeniei. Chişinău, Tipografia AŞM, Systems. Tracts in Modern Physiscs. Springer, 2014, 356 p. ISBN 978-9975-62-000-0) Vol. 281, Springer, 2018, 362 p.  Vlad P.F.; Macaev F.Z. Introductory DOI: 10.1007/978-3-030-01210-6 course on the stereochemistry of organic  Duca Gh.; Lupascu T.; Nicolau E.; compounds. Chisinau, Publishing house of ASM, Culighin E. Ecological and environmental 2014, 200 p. (in Russian). (Влад П.Ф.; Макаев chemistry. Chisinau, Publishing house Ф.З. Вводный курс по стереохимии ”Biotehdesign”, 2018, 250 p. (in Romanian). органических соединений. Кишинэу, (Duca Gh.; Lupașcu T.; Nicolau E.; Culighin E. Типография АН Молдовы, 2014, 200 c. Chimia ecologică și a mediului. Chișinău, ISBN 978-9975-62-360-5) Tipografia ”Biotehdesign”, 2018, 250 p.)

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 Duca Gh.; Nicolau E. Ecological water International Publishing, Switzerland, chemistry. Standards and quality indicators. 2014. Series: Water Science and Technology Chisinau, Publishing house ”Biotehdesign”, 2018, Library, vol. 69, pp. 209-224. ISSN 0921-092X, 75 p. (in Romanian). (Duca Gh.; Nicolau E. ISBN 928-3-319-02707-4. DOI: Chimia ecologică a apei. Standarde și indicatori https://doi.org/10.1007/978-3-319-02708-1_11 de calitate. Chișinău, Tipografia ”Biotehdesign”,  Turta C.; Duca G.; Marin I.; Sirbu D. 2018, 75 p. ISBN 978-9975-108-58-4) Electrochemical Solar Cells Based on Pigments.  Lupascu T.; Nastas R. Synthesis, studying of In: “Management of Water Quality in Moldova”. porous structure, sorption properties and using of Editor Gheorghe Duca, SPRINGER International new active carbons obtained from vegetal raw. In Publishing, Switzerland, 2014. Series: Water book: Adsorption, adsorbents and sorption Science and Technology Library, 2014, volume processes of nano-porous materials. 69, pp. 35-60. ISBN 928-3-319-02707-4. DOI: Moscow: Granita, 2011, p. 425-446. ISBN 978-5- https://doi.org/10.1007/978-3-319-02708-1_3 94691-460-4. (in Russian) (Лупашку Т.Г.,  Geru I.I. Water Structure, Quantum Настас Р.И. Синтез, исследование пористой Nature of Hydrogen Bonds and Diffusion of структуры, адсорбционных свойств и Water Molecules in Chloride Aqueous Solutions. применение новых косточковых активных In: “Management of Water Quality in Moldova”. углей. В книге: Адсорбция, адсорбенты и Ed. by Gheorghe Duca, SPRINGER, Series: адсорбционные процессы в нанопористых Water Science and Technology Library, 2014, материалах. Москва: Граница, 2011. volume 69, pp. 21-34. ISBN 928-3-319-02707-4. с. 425-446. ISBN 978-5-94691-460-4) DOI: https://doi.org/10.1007/978-3-319-02708-  Lupascu T.; Duca Gh. Obtaining of 1_2 medicinal and agricultural preparations based on  Lupascu T.; Mitina T.; Grigoras D. active bioligical active Enoxil synthesized from Methods of determination of microelements in enotanins. In: ”Secondary winemaking products”. biological objects. In: ”Microelements in the Chisinau, Publishing house “Stiinta”, 2011, biosphere objects of the Republic of Moldova and pp.171-234. (in Romanian). (Lupaşcu T.; Duca application in agriculture and medicine”. Gh. Obţinerea preparatelor medicamentoase şi Chisinau, 2016, p. 240-253. (in Romanian). agricole in baza substanţei bioligic active Enoxil (Lupaşcu T.; Mitina T.; Grigoraș D. Metodele de sintetizat din enotaninuri. În: ”Produse vinicole determinare a microelementelor in obiectele secundare”. Chișinău, ÎEP “Ştiinţa”, 2011, biologice. În: ”Microelementele în obiectele pp. 171-234.) biosferei Republicii Moldova şi aplicarea în  Cadocinicov O.; Petuhov O. Possible Use agricultură şi medicină”. Chişinău, 2016, of Certain Mineral Raw Materials of Moldova for pp. 240-253.) DDTs and HCHs Adsorption from Aqueous  Ungur N.; Aricu A.; Grinco M. Solutions. In: ”Environmental Security Occurrence, Biological Activity and Synthesis of Assessment and Management of Obsolete Diterpenoid Amides. In: “Diterpenoids. Types, Pesticides in Southeast Europe”. Springer, 2013. functions and research”. Brandon Jones Ed., Nova pp. 311-321. DOI: https://doi.org/10.1007/978- Science Publishers, INC, New York, 2017, 94-007-6461-3_29 pp. 1-3. ISBN: 978-1-53610-671-8.  Macaev F. Bioactive natural products  Kozakevych R.; Bolbukh Y.; Lupascu L.; from enantiomeric carvones. In: ”Studies in Lupascu T.; Tertykh V. Polymeric Composite Natural Products Chemistry”. Ed. Atta-ur- Films with Controlled Release of Natural Rahman, ELSEVIER, Amsterdam, 2013, vol. 39, Antioxidant Enoxil. In: “Nanochemistry, pp. 233-269. DOI: https://doi.org/10.1016/B978- Biotechnology, Nanomaterials, and Their 0-444-62615-8.00007-2 Applications”. Eds. Fesenko O.; Yatsenko L.  Palii S.; Indricean C.; Revenco M. Mass Springer International Publishing AG, Spectrometry of Metal-Phenolate Moiety- part of Springer Nature, 2018, Springer Containing Complexes and their Derivatives. Proceedings in Physics 214, pp. 149-164. DOI: In: The Chemistry of Metal Phenolates. Wiley https://doi.org/10.1007/978-3-319-92567-7_9 VCH, N.Y., 2014, pp. 220-262. ISBN 978-0-470- The Institute of Chemistry organizes a 97358-5. series of international conferences. The most  Lupaşcu T.; Nastas R.; Rusu V. important are: the Ist (1962) to the XVIIIth Treatment of Sulfurous Waters Using Activated International Conference on “Physical Methods in Carbons. In: “Management of Water Quality in Coordination and Supramolecular Chemistry” Moldova”. Editor Gheorghe Duca, Springer that takes place every 3 years, the International

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Conferences of the Chemical Society of the Institute of Technical Physics, Kazani; Joint Republic of Moldova „Achievements and Institute for Nuclear Research, Dubna; etc. perspectives of modern chemistry” that are USA: Department of Chemistry and forums for researches to present and discuss Biochemistry, University of Texas at Austin; recent results and innovations in chemical Centre for Marine Sciences (CMS), University of sciences (http://chem.asm.md/). North Carolina at Wilmington; In 2006, at initiative of acad. Duca France: Laboratory of synthesis and study of Gheorghe the Institute of Chemistry launched the systems of biological interest and Laboratory of publication of the peer-reviewed (open access) molecular and macromolecular photochemistry, scientific journal CHEMISTRY JOURNAL OF University Blaise Pascal, Aubiere Cedex; MOLDOVA. General, Industrial and Ecological University Aix-Marsellie, France; Institute Laue - Chemistry (ChemJMold), that publishes Langevin; articles in all fields of chemistry Ukraine: Institute of Colloidal Chemistry and (http://www.cjm.asm.md/). Water Chemistry of the NAS of Ukraine; O.O. Over the course of several years the Chuiko Institute of Surface Chemistry of NAS of researchers of the Institute of Chemistry carried Ukraine; out scientific researches on the basis of Poland: Chemistry Faculty of „A. Mickiewicz” collaboration agreements with various University, Poznań; Institute of Physical international scientific centres, which allowed for Chemistry, the AS of Poland; “A. Pawin” Institute mutual visits with the purpose of participating in of Biochemistry and Biophysics, Polish Academy various scientific events, exhibitions, salons and of Sciences, Warszawa; Maria Curie-Sklodowska conducting scientific researches in the fields of University, Lublin, Poland; common interest, also, preparation of scientific Belarus: Institute of Bioorganic Chemistry of the projects and grants (INTAS, NATO, SCOPES, National Academy of Sciences of Minsk; Institute CRDF-MRDA, joint research projects: ASM- of General and Inorganic Chemistry, National Russian Foundation for Fundamental Research; Academy of Sciences of Belarus, Minsk; ASM-Belarusian Republican Foundation for Holland: Agrarian University from Vageningen; Fundamental Research; ASM-Federal Ministry of Spain: Department of Organic Chemistry, Faculty Education of Germany; ASM-National Authority of Pharmacy, University of Valencia, Valencia; for Scientific Research and Innovation from University of Zaragoza; University of Alicante; Romania; STCU-ASM, FP-7, Horizon 2020) [1]. Italy: Institute of Biomolecular Chemistry, CNR, Over the years, the Institute of Chemistry Pozzuoli (Na); Laboratorio di Chimica performed joint research with numerous Bioorgabica Universita degli Studi di Trento; institutions, among which the following should be Istituto di Geologia Ambientale e Geoingegneria mentioned: – CNR, Italia Kavetsky Instytut; Romania: „Politehnica” University, Bucharest; Germany: University of Leipzig, Institute of National Institute of Materials Physics, Bucharest; Organic Chemistry, Leipzig; Institute ECOIND, Bucharest; „C.D. Nenitescu” Slovakia: Ustav Geotechniky Slovenskej Institute of Organic Chemistry of the Romanian Akademie Vied; Academy, Bucharest; „G. Murgulescu” Institute Kazahstan: Nazarbayev University; Institute of of Physical Chemistry of the Romanian Academy, Combustion Problems; Bucharest; “P. Poni” Institute of Macromolecular Canada: Canada Fund for Local Initiatives. Chemistry of the Romanian Academy, Iasi; „A.I. With the launch of the Eastern Partnership Cuza” University, Iasi; „Gh. Asachi” University, (EaP) and the signing of the RM-EU Association Iasi; National Institute for Marine Research and Agreement, new collaborative opportunities Development „Grigore Antipa” (NIMRD); etc. (bilateral and multilateral cooperation) for the United Kingdom: University of Brighton, Institute of Chemistry and the research institutions Brighton; Newcastle University; abroad were opened. The positive dynamics of the Greece: National Technical University of Athens; participation of the scientific community from the Aristotelio Panepistimio Thessalonikis; Republic of Moldova in the EU FP7 Framework Hungary: Budapesti Muszaki Es Program has created prerequisites for joining the Gazdasagtudomanyi Egyetem, Budapest; new EU Framework Program for Research and Russia: Institute of Physical Chemistry and Innovation, Horizon 2020 (2014-2020), aimed at Electrochemistry of the AS of Russian Federation; ensuring the European and global ideas, the Association of Science and Production technologies and human capital by gaining full „Neorganica”, Electrostali, Moscow region; access to the mechanisms of academic mobility,

29 A. Aricu et al. / Chem. J. Mold., 2019, 14(1), 8-31 integration into European and international associated with H2020; Possibilities of business and innovation associations. This international collaboration with research centres allowed Moldovan scientists, research institutes, from other countries in order to access the funds universities and companies to collaborate with through European programs financed by the EU. their counterparts across Europe in key research  Application for participation in areas, while strengthening their own research Knowledge and Innovation Communities (KICs) expertise and capacity. with financial support from the European Institute At present, joint scientific research is of Innovation and Technology. performed in the framework of several  Exploiting the potential of using the international projects: mobility program ASM- research tools of the research infrastructures National Council for Research in Italy; STCU- consortia in the region: CERIC-ERIC; ELI NP, ASM Joint Research and Development program; DANUBIUS, etc. Horizon 2020 program, H2020-MSCA-RISE-  Creation of the "Interdisciplinary National 2016 (Marie Skłodowska-Curie Research and Centre for the Testing of Medical-Biological Innovation Staff Exchange), INFRADEV-02- Properties" of substances synthesized in the 2016-2017, (European Research Infrastructures, research centres of the Republic of Moldova. Coordination and Support Actions).  Creation of a National Specialized Developments in technology, science and Enterprise for the production of biologically society have caused major changes to traditional active substances, in order to select them for systems, structures and ways of working and practical uses in medicine. exciting new opportunities are emerging. These trends are changing the nature of chemistry as a References discipline, the role of chemists and the landscape 1. Lupascu, T.; Vlad, P.F. Aricu, A.; Cocu, M. within which we work. It is essential for research Achievements of the Institute of Chemistry of the institutions to look ahead, anticipate future Academy of Sciences of Moldova at 50 years developments and adapt to stay relevant. It is very anniversary. Chemistry Journal of Moldova. likely that chemical sciences are increasingly General, Industrial and Ecological Chemistry, 2009, 4(1), pp. 8-16. needed to address the challenges of energy and DOI: dx.doi.org/10.19261/cjm.2009.04(1).17 climate change, food production and clean water. 2. Vlad, P. Ed. The Institute of Chemistry of the Chemistry could play an important role in AS MSSR (1959-1984 years). Stiinta: Chisinau, biochemistry and pharmaceutical industry as well 1987, 145 p. (in Russian) as in infrastructure maintenance and development. 3. Batir, D. Restless of memory. The development of chemistry in Moldova and the avatar of the life. Prospective proposals Synthesis. Portraits. Medallions. Reflections. ASM:  Performing scientific research in the field Chisinau, 2007, 348 p. (in Romanian). of: organic chemistry including chemistry of 4. Batir, D. Ablov A. Biography and creativity review. natural compounds, chemistry of coordinative Stiinta: Chisinau, 1986, 220 p. (in Russian). 5. Vlad, P.F.; Terentieva, I.V. Eds. Lazurievski Gh.V. compounds, ecological chemistry, quantum (1906-1987). My life is chemistry of plants. Stiinta: chemistry, analytical chemistry, for solving of the Chisinau, 1995, 175 p. (in Russian). national economy problems. 6. Ablov, A.V.; Conunova, T.B. Eds. Lealicov Iu.S.  Development of new areas of research Biography and creativity review. Stiinta: Chisinau, aligned with the modern themes of European and 1980, 132 p. (in Russian). international research without leaving the main 7. Boggs, J.E.; Polinger, V.Z. Eds. The Jahn-Teller field. Thus, research will be continued towards Effect and Beyond. Selected Works of Isaac the synthesis of inorganic, organic compounds, Bersuker with Commentaries. ASM & Univ. Texas including natural and nanoparticles, as Austin: Chisinau, 2008, 398 p. biologically active substances for medicine, 8. Bersuker, I.B. Quantum chemistry in Moldova – 50 years. Chemistry Journal of Moldova. General, industry and agriculture; supplying of the Industrial and Ecological Chemistry, 2009, 4(1), population of the republic with quality drinking pp. 36-43. water, valorisation of domestic and industrial DOI: dx.doi.org/10.19261/cjm.2009.04(1).14 waste, elaboration of methods of analytical 9. Aricu, A. Ed. Academician Pavel Vlad - an control of pollutants in the environment, which illustrious scientist and tenacious promoter of will contribute to the solving of the important science. Publishing house of ASM: Chisinau, 2009, problems (of the R. Moldova) in the shortest time. 345 p. (in Romanian).  Plenary capitalization of the opportunities 10. Duca, Gh.; Lupascu, T. Eulogy to a man of associated with the country-specific status excellence: Academician Pavel Vlad. Chemistry Journal of Moldova. General, Industrial and

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Acknowledgements The administration of the Institute of Chemistry wishes to express its gratitude to the Institute’s researchers for their dedication and commitment to research, and research partners for joint results and successful stories together. Special thanks to directors of the scientific centers, academician Gheorghe DUCA and academician Tudor LUPASCU for their continuous guidance and scientific support, as well as to laboratories leaders.

The Institute of Chemistry is always open to cooperation and initiation of new research relationships.

Address: Dr. habilitate Aculina ARICU The Institute of Chemistry Director of the Institute of Chemistry 3, Academiei str. Chisinau, MD-2028 Dr. Raisa NASTAS Republic of Moldova Deputy director of the Institute of Chemistry e-mail: [email protected]; [email protected] Dr. Maria COCU http://chem.asm.md/ Scientific secretary of the Institute of Chemistry