Molecular Pharmacology

Early failure of N-Methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

Tatyana Chernova, Joern R. Steinert, Paul Richards, Rajendra Mistry, R.A. John Challiss, Rebekah Jukes-Jones, Kelvin Cain, Andrew G. Smith, and Ian D. Forsythe

Supplemental table1. Putative heme-binding identified in SA-treated neuronal cells using hemin-agarose affinity chromatography followed by SDS-PAGE and proteomics analysis.

Protein name Number of Unique Peptides Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) (GAPDH) - Mus musculus (Mouse) 6 Dihydropyrimidinase-related 3 (DRP-3) (Unc-33- like phosphoprotein) (ULIP protein) - Mus musculus (Mouse) 12 ATP synthase subunit beta, mitochondrial precursor (EC 3.6.3.14) - Mus musculus (Mouse) 11 Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) - Mus musculus (Mouse) 4 Elongation factor 1-alpha 2 (EF-1-alpha-2) (Elongation factor 1 A-2) (eEF1A-2) (Statin S1) - Mus musculus (Mouse) 4 Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (ULIP3 protein) - Mus musculus (Mouse) 6 ADP/ATP translocase 1 (Adenine nucleotide translocator 1) (ANT 1) (ADP,ATP carrier protein 1) (Solute carrier family 25 member 4) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (mANC1) - Mus musculus (Mouse) 2 Dihydropyrimidinase-related protein 2 (DRP-2) (ULIP 2 protein) - Mus musculus (Mouse) 5 Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) - Mus musculus (Mouse) 6 ATP synthase subunit alpha, mitochondrial precursor (EC 3.6.3.14) - Mus musculus (Mouse) 6 Heterogeneous nuclear ribonucleoprotein K - Mus musculus (Mouse) 5 , alpha cardiac muscle 1 (Alpha-cardiac actin) - Mus musculus (Mouse) 3 alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain) - Mus musculus (Mouse) 6 Synapsin-1 (Synapsin I) - Mus musculus (Mouse) 6 Heterogeneous nuclear ribonucleoprotein A1 (Helix- destabilizing protein) (Single-strand-binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase- inhibitor suppressed) - Mus musculus (Mouse) 4 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (EC 3.1.3.16) (PP-1A) - Mus musculus (Mouse) 4 -2 (Neuronal tropomodulin) (N-Tmod) - Mus musculus (Mouse) 3 F-actin capping protein subunit alpha-2 (CapZ alpha-2) - Mus musculus (Mouse) 5 Glutathione S-transferase P 1 (EC 2.5.1.18) (GST YF-YF) (GST-piB) (GST class-pi) (Gst P1) (Preadipocyte growth factor) - Mus musculus (Mouse) 3 Drebrin (Developmentally-regulated brain protein) - Mus musculus (Mouse) Alpha-centractin (Centractin) (Centrosome-associated actin homolog) (Actin-RPV) (ARP1) - Mus musculus (Mouse) 3 Non-POU domain-containing octamer-binding protein (NonO protein) - Mus musculus (Mouse) 2 ATP synthase O subunit, mitochondrial precursor (EC 3.6.3.14) (Oligomycin sensitivity conferral protein) (OSCP) - Mus musculus (Mouse) 3 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65) - Mus musculus (Mouse) 2 Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) - Mus musculus (Mouse) 3 Leucine-rich repeat-containing protein 59 - Mus musculus (Mouse) 3 Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) - Mus musculus (Mouse) 3 Syntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) - Mus musculus (Mouse) 2 Vacuolar ATP synthase subunit D (EC 3.6.3.14) (V- ATPase subunit D) (Vacuolar proton pump subunit D) (V- ATPase 28 kDa accessory protein) - Mus musculus (Mouse) 2 ATP synthase D chain, mitochondrial (EC 3.6.3.14) - Mus musculus (Mouse) 2 Dihydropyrimidinase-related protein 5 (DRP-5) (Collapsin response mediator protein 5) (CRMP-5) - Mus musculus (Mouse) 2 polymerization-promoting protein (TPPP) - Mus musculus (Mouse) 2 Ras-related protein Rab-14 - Mus musculus (Mouse) 2 T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) - Mus musculus (Mouse) 2