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Supplementary Online Content

Roussos P, Guennewig B, Kaczorowski DC, Barry G, Brennand KJ. Activity- dependent changes in expression in -induced pluripotent stem neurons. JAMA Psychiatry. Published online October 12, 2016. doi:10.1001/jamapsychiatry.2016.2575

eAppendix. Methods eReferences. eFigure 1. Multidimensional scaling of RNA sequencing of hiPSC neurons eFigure 2. Box plots showing the distributions of normalized gene expression in schizophrenia vs controls eFigure 3. Quantitative real-time PCR (qRT-PCR) validation of DEGs for Disease status (schizophrenia vs control) eFigure 4. Binned density scatterplot eFigure 5. Pathway enrichment analysis for differential expressed between control and schizophrenia neurons across a group of gene sets for known molecular pathways and biological processes eFigure 6. Box plots showing the distributions of normalized gene expression in schizophrenia vs controls stratified by treatment with PBS and potassium chloride for SLC38A2 and THNSL1 genes eFigure 7. Binned density scatterplots comparing the log2 fold-change for PCID treatment eFigure 8. Pathway enrichment analysis for differential expressed genes eFigure 9. Quantitative real-time PCR (qRT-PCR) validation of DEGs for PCID alterations of gene expression eFigure 10. Percentage of variance explained by each experimental variable for the top 20 control signatures eFigure 11. Box plot showing the distributions of normalized gene expression in schizophrenia vs controls stratified by treatment with PBS and potassium chloride for KIF5B gene eFigure 12. Pathway enrichment analysis for the top 5% of control signatures across a group of gene sets for known molecular pathways and biological processes eFigure 13. Module eigengene patterns and enrichment scores of the top 5 enriched functional gene sets for modules that are significant at FDR ≤0.05 with diagnosis (brown and turquoise) or PCID (yellow and green) eFigure 14. Intramodular hub genes for modules that are significantly associated with disease and PCID eTable 1. Primers for real-time PCR

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 2. Demographic and sequencing data for the schizophrenia and control samples eTable 3. Differentially expressed genes for diagnosis (control vs schizophrenia) at FDR 5% eTable 4. Differentially expressed genes for PCID (untreated or treated with potassium chloride) at FDR 5% eTable 5. Differentially expressed genes for PCID in controls at FDR 5% eTable 6. Differentially expressed genes for PCID in schizophrenia at FDR 5% eTable 7. Summary of coexpression modules associated with diagnosis and PCID eTable 8. Summary of genetic enrichment with coexpression modules

This supplementary material has been provided by the authors to give readers additional information about their work.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eAppendix

Methods

Generation of hiPSC neurons

Neural progenitor cells (NPCs) were differentiated from hiPSCs as previously

described1,2. We used hiPSCs from 4 cases with schizophrenia and 4 controls that have

been reported in previous studies1,2. NPCs were maintained at high density, grown on

Matrigel (BD)-coated plates in NPC media (DMEM/F12, 1x N2, 1x B27-RA

(Invitrogen), 1 µg/ml Laminin and 20 ng/ml FGF2) and split approximately 1:4 every

week with Accutase (Millipore) (for more information, see3). For neural differentiations,

dissociated NPCs were plated in neural differentiation media (DMEM/F12, 1x N2, 1X

B27-RA, 20 ng/ml BDNF (Peprotech), 20 ng/ml GDNF (Peprotech), 1 mM dibutyrl-

cyclicAMP (Sigma), 200 nM ascorbic acid (Sigma) onto polyornithine/Laminin-coated

plates at 200,000 cells per well of a 6-well plate. hiPSC derived-neurons were

differentiated for 6 weeks; media was replaced every 5-7 days. Neurons were treated with

50mM KCl (or PBS vehicle control) for the final three hours prior to harvest.

RNA preparation and sequencing

Total RNA was isolated from approximately density-matched plates (initially seeded with

~200,000 NPCs per well) using TRIzol (Thermo Fisher), according to the manufacturer’s

instructions. Briefly, RNA was chloroform extracted, pelleted with isopropanol, washed

with 70% ethanol and resuspended in water. RNA was treated with RQ1 RNAse-free

DNAse (Promega) for 30 minutes at 37C and then the reaction was inactivated by

incubation with EGTA Stop buffer at 65C for 10 minutes. The RNA Integrity Number

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 (RIN) was determined using an RNA Nano chip (Agilent Technologies) on the Agilent

2100 Bioanalyzer. All samples have high RIN (mean ± standard deviation: 9.53 ± 0.22).

500 ng of total RNA was used as input material for library preparation using the TruSeq

Stranded Total RNA Sample Prep Kit (LT) (Illumina, USA) according to manufacturer’s

instructions. Individual libraries were indexed as recommended by Illumina.

Mapping and Normalization of Gene Expression

Mapping and quantification: We mapped reads to hg19 reference using TopHat

(version 2.0.9) and Bowtie (version 2.1.0), with the default parameters. Known Ensembl

gene levels (version 70) were quantified by HTSeq (version 0.6.0) in intersection-strict

mode. A sample-by-gene read count matrix was generated for 16 samples by 56,632

Ensembl genes. Scaling normalization to remove composition biases in sequencing data

was applied to log(CPM) (read Counts Per Million total reads) using the trimmed mean

of M-values (TMM) method4.

Covariates exploration: We selected covariates for inclusion to differential gene

expression analysis by performing principal component analysis of the normalized read

count matrix and examining which variables were significantly correlated with the high-

variance components (explaining > 1% of the variance) of the data. This identified five

covariates, which encompassed 5 statistical degrees of freedom (df): Diagnosis (control

and schizophrenia), Treatment (PBS and KCl), Gender (Male and female), Age and RIN.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Normalized gene expression: We used the voomWithQualityWeights function from the

limma package to model the normalized read counts. This function estimates weights by

combining observational-level weights from voom with sample-specific weights

estimated using the arrayWeights function. Briefly, in the first step voom estimates

confidence weights for each normalized observed read count by residualizing on the

covariates, fitting a mean-variance relationship function across all genes, using the fitted

function to estimate the variance of a particular read count observation, and then setting

the observation weight to be the inverse of the corresponding estimated variance. This is

an important step to model the statistical sampling of gene expression level, since larger

log(CPM) typically exhibit lower variance. In the second step, the estimated sample

weights are used to obtain observational weights that take into account variations in

sample quality. The variance model is then fitted a second time and a final set of

modified weights is used in the linear modeling and differential expression analysis.

Differential analysis: For each transcript, we fit weighted least-squares linear regression

models for the effect on gene expression of each variable on the right-hand side:

Gene expression ~ diagnosis + treatment + covariates

Then, for each transcript, the diagnosis (control and schizophrenia) and treatment (PBS

and KCl) coefficients were statistically tested for being non-vanishing, implying an

estimated effect, above and beyond any other effect from the covariates (Gender, Age

and RIN) on gene expression using linear regression utilities in the limma package. P-

values were then adjusted for multiple hypotheses testing using false discovery rate

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 (FDR) estimation, and the differentially expressed genes were determined as those with

an estimated FDR ≤0.05.

Explore effect of 3-hour treatment of PBS or KCl on gene expression

While our study is well controlled to detect differences between schizophrenia and

controls and/or in response to depolarization, it is unclear if 3-hour exposure to either

KCl or PBS changes gene expression, especially transcripts related to stress or starvation

molecular processes. To explore this hypothesis, we leverage RNAseq data generated in

the same samples without 3-hour exposure to 50mM KCl or PBS and explore for

differences that exist in gene expression based on the following model:

Gene expression ~ Cohort + Covariates

Where cohort is Neurons with and without 3-hour exposure to 50mM KCl or PBS and

covariates included Age, sex and RIN. We identified a set of 792 that are DEG among the

2 cohorts, but this is not surprising since the experiments were conducted independently

at different time points (and were sequenced in different facilities) so that will include

technical and experimental batch effect. We then used the 792 genes and performed

pathway analysis to determine if pathways related to stress response are significantly

enriched. The pathways that were enriched at FDR <20% are included below.

Annotation Pval O FD ue R R go:CC| 1.8E 13 2.5E -08 .0 -06 go:BP|nucleosome assembly 8.0E 6. 9.4E -07 4 -05 go:BP|cerebellar Purkinje cell layer development 5.9E 14 6.7E -05 .0 -03 go:MF|beta- binding 1.6E 4. 1.7E -04 1 -02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 go:BP|positive regulation of DNA binding 4.0E 8. 3.9E -04 4 -02 go:BP|negative regulation of myoblast differentiation 4.4E 11 4.0E -04 .6 -02 go:BP|vocalization behavior 4.4E 11 4.0E -04 .6 -02 go:BP|negative regulation of from RNA polymerase II 8.9E 1. 7.8E -04 8 -02 go:BP|negative regulation of BMP signaling pathway 9.9E 5. 8.3E -04 4 -02 go:BP|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole 1.6E 7. 1.3E propionate selective glutamate activity -03 8 -01 go:BP|somatic stem cell maintenance 2.0E 4. 1.6E -03 7 -01 go:BP|mammary gland development 2.3E 7. 1.7E -03 0 -01

Pathways related to stress response such as go:BP|cellular response to oxidative stress,

go:BP|intrinsic apoptotic signaling pathway in response to oxidative stress and

go:BP|positive regulation of stress-activated MAPK cascade were not enriched (all P

values > 0.6). This exploratory analysis indicates that the RNAseq profile of neurons that

were exposed to PBS or KCl compared to neurons that were not, does not involve stress-

related gene dysregulation.

Explore the differentiation state of the cells

Differences among cases and controls or in response to KCl might be due to different

differentiation state of the cells. To explore this hypothesis we examine the distribution of

the gene expression of neurons derived from control or cases with schizophrenia for

transcripts that are:

1. Altered in NPCs vs neurons: to define these transcripts, we used RNA-seq data from

NPCs (n=11) and their matched differentiated neurons. We defined 7,275 NPC vs Neuron

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 signatures by performing DEG analysis after controlling for covariates, including

diagnosis (control vs schizophrenia), age, sex and RIN.

2. Expressed in prenatal stages: We used data from the BrainSpan

(http://developinghumanbrain.org) and performed cluster analysis to define prenatal

biased genes, as described in a recent paper5. Briefly, we used data (transformed to

log2(RPKM+1) scale) from the dorsolateral prefrontal cortex (DLPFC) and

(HPC) and for each gene we calculated the median scaled expression values across three

groups of samples: first trimester (T1, 0-12 weeks), second trimester (T2, 13-24 weeks)

and all postnatal samples. We applied K-means clustering to separate distinct

developmental trajectories contrasting genes that show either prenatal or postnatal

expression biases, genes that are unbiased (showing similar expression across time

points) and genes that do not show any expression in . Based on inspection of the

ratio of between-cluster to total-sample sum of squares and the number of genes assigned

to each cluster, we selected a K = 8 class solution (that captures 93.6% of the total

variance). We used a signature of 1,830 prenatal-biased expressed genes in the analysis

described below.

Using the 2 gene sets described above, we asked whether the expression of these specific

genes show different distribution in control and schizophrenia neurons. We did not find a

significant difference in the gene expression among cases with schizophrenia and

controls of transcripts that are NPC vs Neuron signatures (T test: t = 0.76, P = 0.45) or

expressed in early development (T test: t = 1.5, P = 0.14).

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Real-Time PCR

500ng of total RNA was used for cDNA synthesis using SuperScript III First-Strand

Synthesis System for RT-PCR (ThermoFisher Scientific C#:18080051) following the

manufacturer’s instructions for random priming. Each cDNA sample was amplified in

triplicate using SYBR Green PCR Master Mix (ThermoFisher Scientific C#4309155) on

the CFX384 Touch Real-Time PCR Detection System (Bio-Rad). Briefly, the reaction

conditions consisted of 1 μl of cDNA (diluted 1:20) and 0.4 μM primers in a final volume

of 10 μl of mastermix. Initial denaturation of 10 minutes at 95°C was required to activate

the AmpliTaq Gold DNA Polymerase. This was then followed by 35 cycles consisting of

denaturation at 95°C for 15 seconds and annealing/extension at 60°C for 60 seconds.

Immediately following the amplification, a melt curve analysis was performed as per the

default setting on the machine. Briefly, the samples were subjected to 65°C - 95°C which

increased at 0.5°C increments and 5 seconds per step. The primers used for this analysis

are described in eTable 1.

Weighted gene coexpression analysis (WGCNA)

We constructed unsigned gene coexpression networks using the WCGNA package in R,

starting with the normalized and residualized (removing effect of age, gender and RIN)

expression data for 13,903 genes. The connectivity metric between a pair of genes i and j,

or kij, is a transformed correlation between their expression profiles, with the matrix A =

β (kij) known as the unsigned adjacency matrix. kij is defined as |rij| , using the absolute

value of rij, the Pearson correlation coefficient between the profiles of genes i and j, and β

is the parameter of a power function. β is selected using the fitting index proposed by

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Zhang et al.6, i.e., to maximize the scale-free topology model fitting index R2 of the linear

model that regresses log(p(k)) on log(k), where k is connectivity and p(k) is the frequency

distribution of connectivity. For the current data, we used an R2 cutoff of 0.85, which

corresponded to a selection of β = 7.

To explore the modular structures of the coexpression network, the adjacency matrix is

further transformed into a topological overlap matrix7. Use of the topological overlap

metric leads to more cohesive and biologically meaningful modules, since it not only

represents the direct correlation between two genes but also incorporates their indirect

interactions through other genes in the network6,7. Genes were organized into discrete

modules of highly coregulated genes (either correlated or anti-correlated) using hybrid

dynamic tree-cutting algorithm to dynamically cut clustering dendrogram branches into

discrete subsets of gene modules8. The minimum module size was set to 30 genes and the

minimum height for merging modules was set at 0.3. Ordered from largest (the module

containing the most genes) to smallest, each module is sequentially assigned a color

name. The less well-connected genes are arbitrarily grouped in the gray module.

Gene sets for enrichment analyses

To further characterize the DEGs and coexpression genes, we performed enrichment

analysis, using a group of gene sets for known molecular pathways and biological

processes, including: (GO) sets of molecular functions (MF), biological

processes (BP), and cellular components (CC) (http://www.geneontology.org)9; the

Reactome data set (http://www.reactome.org)10; and the HUGO

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Committee (HGNC) gene families (http://www.genenames.org)11. We filtered these data

sets to the ones that are relevant to our data set by keeping a gene set if ≥ 10% of the

genes were expressed and had a final number of genes between 10 and 1,000. We

removed redundant gene sets, by removing Reactome or HGNC sets that overlapped

(Jaccard similarity coefficient > 0.5) with GO included sets. This procedure yielded 2,902

gene sets in total: 1,938 sets from GO, 824 from Reactome, and 140 gene families.

In addition, to further characterize the data-driven co-expressed modules, we generated a

group of gene sets derived from previous schizophrenia genetic findings, cell type-

specific studies or coexpression analyses:

1. Gene sets previously shown to be enriched for schizophrenia candidate genes,

including: a) Genes regulated by FMRP (fragile X mental retardation ) targeting12;

b) Predicted targets of miR-137 from TargetScan version 6.213; c) Voltage-gated calcium

channels14; and, d) Subsets of genes whose protein products are localized to the

postsynaptic density of neurons, including those involved in glutamatergic

neurotransmission15.

2. Cell type- or compartment-specific annotations, including: a) Cell type markers based

on in situ hybridization in brain tissue (abbreviated as ABA for Allen Brain

Atlas16; b) Definite (10+ fold) enrichment for seven brain cell types, estimated based on

FPKM for the given cell type vs. the average FPKM in the remaining types (abbreviated

as Zhang17. For each cell type, only genes with FPKM > 1 were considered; c) Markers

for different organelles and cellular compartments (markers of organelles, or MO)18-21; d)

Mitochondrial genes from the somatic vs. synaptic fraction of mouse cells

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 (MitochondrialType)22; and, e) Cell-type markers based on single-cell RNA-seq analysis

in mouse brain23. Enrichment of genes expressed across 9 cell types was calculated by

comparing expression in each of the nine major classes individually against the basal

expression given by the linear regression. We retained only genes that were enriched with

99.9% posterior probability in the cell-type of interest, and not enriched in any other

class.

3. Previous WGCNA studies in brain tissue and schizophrenia, including: a) modules

from the cortex (CTX) network from human brain tissue24; b) modules showing region-

specificity in both human and chimp (HumanChimp)25; c) modules from human

(HumanMeta) and mouse (MouseMeta) brain tissue26; d) modules from neuronal-cell-

type-selection experiment in mouse21,22; e) modules (modules 1, 2, 7, 16, and 21) that are

significantly enriched in genes differentially expressed in DLPFC between subjects with

schizophrenia (n = 47) versus control (n = 54) subjects (Torkamani27); f) modules (M1A

and M3A) that are significantly affected in the parietal cortex of subjects with

schizophrenia (n = 50) versus control (n = 50) subjects (Chen28); and, g) a module (tan

module) that is affected in peripheral blood of cases with schizophrenia (deJong29).

The genes in each module were tested for overlap using Fisher’s exact test and FDR

correction across all modules and all gene sets tested.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Enrichment of modules with genetic risk loci

We tested the enrichment of modules for genes found in genetic loci previously

associated with schizophrenia.

The following schizophrenia associated data were used in the current study: a) 108 loci

discovered in a common variant genome-wide association (GWAS) meta-analysis study

of 36,989 schizophrenia cases and 113,075 controls30, b) a literature consensus of 12

copy number variant (CNV) regions collated from numerous rare CNV studies31, and c)

756 nonsynonymous (mostly missense, but also including 114 loss-of-function

[nonsense, essential splice site, or frameshifting indels]) de novo mutations discovered

from exome-sequencing across 1,024 schizophrenia probands and their parents32-36. In

addition, we used published de novo mutations across three neurodevelopmental

disorders, including: a) autism spectrum disorders (ASD): 3,446 nonsynonymous and 579

loss-of-function mutations37-40, b) intellectual disability (ID): 259 nonsynonymous and 67

loss-of-function mutations41-44, and c) epilepsy: 341 nonsynonymous and 58 loss-of-

function mutations45,46.

The enrichment across the three classes of genetic variation was tested using the tools

described below. The outcome of each test was statistically integrated using the Fisher’s

method for combining p-values.

a) INRICH47 was used to assess the enrichment of 108 schizophrenia-associated GWAS

loci (with a 20 kb window added both upstream and downstream30) or 12 schizophrenia-

associated CNV regions (without any additional genomic window) with coexpression

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 modules. The significance was determined with permutation analysis, by performing

10,000 permutations. For GWAS loci, the random regions were generated by matching to

the associated loci in terms of the number of SNPs, SNP density, and the number of

overlapping genes. The random SNPs were selected from the full data set of SNPs tested

for schizophrenia association. For CNVs, the random regions were generated by

matching to the associated loci in terms of the number of overlapping genes.

b) We assessed the enrichment of de novo mutations with coexpression genes using

DNENRICH32 (https://psychgen.u.hpc.mssm.edu/dnenrich). The significance was

determined with permutation analysis, by performing 50,000 permutations. The random

de novo mutations were matched to the observed mutations for their trinucleotide base

context and functional consequence and then placed in the genome uniformly at random

to account for gene size.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eReferences

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 1. Multidimensional scaling of RNA sequencing gene expression of hiPSC

neurons from each of four control and four cases with schizophrenia with (KCl) and

without (PBS) potassium chloride treatment segregates samples along the three

leading fold change dimensions.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 2. Box plots showing the distributions of normalized gene expression in

schizophrenia vs. controls stratified by treatment with PBS and potassium chloride

for CACNB2 and GRM3 genes.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 3. Quantitative real-time PCR (qRT-PCR) validation of DEGs for disease

status (schizophrenia vs. control).

qRT-PCR shows that (A) IGF1 (B) TCF4 and (C) GRM3 transcripts are significantly

increased in both control and schizophrenia neurons while CACNB2 transcript is

significantly reduced. (* p value< 0.05; Mann-Whitney U test).

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 4. Binned density scatterplot comparing the log2 fold-change for control vs.

schizophrenia differential expression between the current data set and a previous

hiPSC neuron cohort assayed on microarrays.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 5. Pathway enrichment analysis for differential expressed genes between

control and schizophrenia neurons across a group of gene sets for known molecular

pathways and biological processes.

The x-axis represents −log10 P value, and the y-axis denotes pathways. The numbers on

each bar indicates the fold enrichment.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 6. Box plots showing the distributions of normalized gene expression in

schizophrenia vs. controls stratified by treatment with PBS and potassium chloride

for SLC38A2 and THNSL1 genes.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 7. Binned density scatterplots comparing the log2 fold-change for PCID

treatment differential expression between the current data set and a previous gene

expression data set in mouse cortical neurons after PCID for 1 hour (left plot) or 6

hours (right plot).

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 8. Pathway enrichment analysis for differential expressed genes between

untreated and treated potassium chloride-induce depolarization across a group of

gene sets for known molecular pathways and biological processes.

The x-axis represents −log10 P value, and the y-axis denotes pathways.

The numbers on each bar indicates the fold enrichment.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 9. Quantitative real-time PCR (qRT-PCR) validation of DEGs for PCID

alterations of gene expression.

qRT-PCR shows that (A) SLC38A2 transcript is significantly increased in both controls

and schizophrenia neurons after 3 hours post KCl activation (****adjusted p value<

0.0001; One-way ANOVA test with a Tukey’s multiple comparison post hoc test), (B)

FOS transcript is upregulated upon activation in both controls and schizophrenia although

the extent of activation in schizophrenia neurons is less due to an increase in baseline

FOS levels in schizophrenia neurons (*adjusted p value< 0.05, **0.01, ***0.001; One-

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 way ANOVA test with a Tukey’s multiple comparison post hoc test), (C) LFNG

transcript is only significantly downregulated in controls following activation (*adjusted

p value< 0.05; One-way ANOVA test with a Tukey’s multiple comparison post hoc test),

similar to (D) THNSL1 transcript.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 10. Percentage of variance explained by each experimental variable for the

top 20 control signatures (largest difference for PCID variance explained in controls

vs. schizophrenia).

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 11. Box plot showing the distributions of normalized gene expression in

schizophrenia vs. controls stratified by treatment with PBS and potassium chloride

for KIF5B gene.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 12. Pathway enrichment analysis for the top 5% of control signatures across

a group of gene sets for known molecular pathways and biological processes.

The x-axis represents −Log10 P value, and the y-axis denotes pathways. The numbers on

each bar indicates the fold enrichment

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 13. Module eigengene patterns and enrichment scores of the top five

enriched functional gene sets for modules that are significant at FDR ≤ 0.05 with

diagnosis (brown and turquoise) or PCID (yellow and green).

Left: barplots indicate the level of MEs across samples. Samples are ordered by control-

PBS, control-KCl, schizophrenia-PBS and schizophrenia-KCl, as illustrated by the key at

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 the bottom. Right: Pathway enrichment analysis across group of gene sets for known

molecular pathways and biological processes (top) or hypothesis driven gene sets

(bottom). The x-axis represents −log10 P value, and the y-axis denotes pathways. The

numbers on each bar indicates the fold enrichment.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eFigure 14. Intramodular hub genes for modules that are significantly associated

with disease and PCID and have a significant enrichment for genetic variants are

shown.

Genes that have a genetic association for schizophrenia (GWAS, CNV or de novo) or are

DEGs for diagnosis (brown and tuqrquoise) or PCID (yellow) are illustrated. NS: non-

synonymous; LoF: loss-of-function mutations.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 1. Primers for real-time PCR

Category Target Gene Primer sequence (5’-3’) Housekeeping GAPDH Forward – CAGCCTCAAGATCATCAGCA Reverse – ATGGACTGTGGTCATGAGTC schizophrenia IGF1 Forward – AGCTGTGATCTAAGGAGGCT vs. control Reverse – AAATGTACTTCCTTCTGGGTC DEGs TCF4 Forward – ACATGCATGGAATCATTGGAC Reverse – GTGAATGTCTGTTGGCTGAAA CACNB2 Forward – AGTCGAGACTCTGCCTACGT Reverse – GGGTCTCGTCTCTGTGGTTG GRM3 Forward – ATGCACTGTGTACGCCTTCA Reverse –AAGGCCAACCAGATGATGCA PCID DEGs SLC38A2 Forward – CTGATTGTGGTCATTTGCAAG Reverse – AGCAGGTACAAGAGCTGTTG FOS Forward – CCGGAGGAGGGAGCTGACTGA Reverse – GGATCTTGCAGGCAGGTCGGTG THNSL1 Forward – ACGTTTGGCCTGAAGACTGT Reverse –TTGCAGGAACAAAGAGGCCA LFNG Forward – CATCACAAACTGCTCGGCC Reverse – AGAACCACTTCCTGCCGGA

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 2. Demographic and sequencing data for the schizophrenia and control

samples.

Pat Co S Ethnicity Age at Age of Hosp Family History Tr RIN Inpu Mapp Exo ien riel e Biopsy Onset italiz eat (PBS t PE ed PE n t l x (years) (years ation me /KCl read reads cou ID ID ) s? nt ) s nts C1 G F Causasian 25 - - unknown PB 9.9 21,0 19,98 13,2 M0 S 00,3 8,979 45,5 36 61 33 51 KC 9.9 11,6 11,13 7,44 l 68,1 1,042 0,64 99 3 C2 G F Causasian 20 - - unknown KC 9.5 19,9 18,98 13,4 M0 l 39,0 9,823 44,8 45 32 76 06 PB 9.5 31,5 30,15 21,0 S 92,4 7,794 43,2 10 03 C3 AG F Causasian 24 - - unknown KC 9.3 17,5 16,90 11,0 09 l 00,4 0,497 74,9 31 97 95 9 PB 9.4 12,0 11,65 7,36 S 97,1 8,604 0,59 26 8 C4 AG F Causasian 25 - - unknown KC 9.5 24,5 22,47 13,9 09 l 04,4 4,668 81,9 42 00 81 9 PB 9.6 32,1 30,70 19,0 S 36,3 5,172 72,8 14 41 P1 G M Causasian 22 6 ? unknown KC 9.4 25,9 24,81 16,7 M0 l 37,5 0,366 23,5 20 85 24 38 PB 9.3 25,2 23,79 15,3 S 41,5 6,016 48,1 87 75 P2 G M Causasian 26 unkno ? father and sister PB 9.2 19,3 17,58 10,9 M0 Jewish / wn affected; brother S 84,6 5,046 75,0 17 Scandanav autistic at age 24 17 92 ian four KC 9.5 30,9 29,27 18,8 l 47,2 8,087 60,2 17 65 P3 G F Causasian 27 unkno Yes father and KC 9.4 27,3 26,20 18,0 M0 Jewish wn brother affected l 51,1 9,368 94,8 18 73 55 35 PB 9.5 19,7 18,81 12,5 S 00,9 2,965 76,1 35 46 P4 G M Causasian 23 15 Yes affected father, PB 9.8 13,3 11,22 9,29 M0 Jewish anorexic S 80,0 7,775 4,07 24 /schizoid sister 60 6 97 KC 9.8 11,8 9,840, 8,48 l 14,8 050 4,97 10 1

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 3. Differentially expressed genes for diagnosis (control vs. schizophrenia) at

FDR 5%

Ensembl Gene symbol logFC t P FDR ENSG00000156675 RAB11FIP1 -8.12 -15.53 1.30E-09 1.80E-05 ENSG00000175356 SCUBE2 -8.83 -13.9 4.90E-09 2.70E-05 ENSG00000154217 PITPNC1 -5.25 -13.69 5.90E-09 2.70E-05 ENSG00000092969 TGFB2 -6.1 -13.08 1.00E-08 3.30E-05 ENSG00000117318 ID3 10.77 12.82 1.30E-08 3.30E-05 ENSG00000095203 EPB41L4B -8.1 -12.7 1.40E-08 3.30E-05 ENSG00000173530 TNFRSF10D 9.27 12.33 2.00E-08 4.00E-05 ENSG00000139970 RTN1 -5.66 -11.87 3.20E-08 5.10E-05 ENSG00000185008 ROBO2 -7.6 -11.72 3.70E-08 5.10E-05 ENSG00000139292 LGR5 -10.02 -11.7 3.80E-08 5.10E-05 ENSG00000130707 ASS1 8.03 11.58 4.20E-08 5.10E-05 ENSG00000112309 B3GAT2 -6.28 -11.5 4.60E-08 5.10E-05 ENSG00000164796 CSMD3 -5.09 -11.45 4.80E-08 5.10E-05 ENSG00000164761 TNFRSF11B 7.32 11.18 6.40E-08 6.30E-05 ENSG00000138119 MYOF 5.71 11.11 6.80E-08 6.30E-05 ENSG00000169306 IL1RAPL1 -10.07 -10.94 8.10E-08 7.10E-05 ENSG00000091656 ZFHX4 -4.79 -10.84 9.00E-08 7.40E-05 ENSG00000211448 DIO2 -10.23 -10.78 9.70E-08 7.50E-05 ENSG00000088992 TESC 7.48 10.64 1.10E-07 8.20E-05 ENSG00000146910 CNPY1 9.16 10.52 1.30E-07 8.90E-05 ENSG00000185885 IFITM1 11.13 10.43 1.40E-07 8.90E-05 ENSG00000152661 GJA1 -5.26 -10.43 1.40E-07 8.90E-05 ENSG00000125968 ID1 9.66 10.3 1.60E-07 9.80E-05 ENSG00000172915 NBEA -3.6 -10.16 1.90E-07 1.10E-04 ENSG00000152977 ZIC1 9.72 9.73 3.10E-07 1.70E-04 ENSG00000157617 C2CD2 4.32 9.71 3.20E-07 1.70E-04 ENSG00000107742 SPOCK2 4.08 9.68 3.30E-07 1.70E-04 ENSG00000011201 KAL1 -10.17 -9.62 3.50E-07 1.70E-04 ENSG00000121207 LRAT -8.23 -9.59 3.60E-07 1.70E-04 ENSG00000174963 ZIC4 9.31 9.54 3.90E-07 1.80E-04 ENSG00000164418 GRIK2 -5.75 -9.3 5.10E-07 2.30E-04 ENSG00000165300 SLITRK5 -5.54 -9.21 5.70E-07 2.50E-04 ENSG00000066468 FGFR2 -7.27 -9.17 6.00E-07 2.50E-04 ENSG00000044524 EPHA3 -6.1 -9.12 6.40E-07 2.50E-04

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000175497 DPP10 -6.1 -9.11 6.50E-07 2.50E-04 ENSG00000138722 MMRN1 8.28 9.09 6.60E-07 2.50E-04 ENSG00000144857 BOC 3.44 9.08 6.70E-07 2.50E-04 ENSG00000100557 C14orf105 9.84 9.08 6.70E-07 2.50E-04 ENSG00000092068 SLC7A8 9.18 8.95 7.80E-07 2.70E-04 ENSG00000144681 STAC -6.71 -8.95 7.90E-07 2.70E-04 ENSG00000187416 LHFPL3 -10.21 -8.9 8.40E-07 2.80E-04 ENSG00000135547 HEY2 -5.19 -8.8 9.40E-07 3.10E-04 ENSG00000153179 RASSF3 6.46 8.79 9.60E-07 3.10E-04 ENSG00000107518 ATRNL1 -3.67 -8.76 9.90E-07 3.10E-04 ENSG00000102265 TIMP1 3.65 8.72 1.00E-06 3.20E-04 ENSG00000137968 SLC44A5 -5.55 -8.71 1.10E-06 3.20E-04 ENSG00000169242 EFNA1 4.97 8.68 1.10E-06 3.20E-04 ENSG00000153976 HS3ST3A1 10.16 8.67 1.10E-06 3.20E-04 ENSG00000169213 RAB3B -4.62 -8.6 1.20E-06 3.50E-04 ENSG00000165449 SLC16A9 6.84 8.53 1.30E-06 3.70E-04 ENSG00000184408 KCND2 -7.05 -8.47 1.40E-06 3.90E-04 ENSG00000019991 HGF 10.29 8.42 1.50E-06 4.10E-04 ENSG00000102290 PCDH11X -5.99 -8.39 1.60E-06 4.10E-04 ENSG00000133424 LARGE -4.11 -8.38 1.60E-06 4.10E-04 ENSG00000153406 NMRAL1 6.97 8.33 1.70E-06 4.40E-04 ENSG00000232480 . -7.17 -8.24 1.90E-06 4.80E-04 ENSG00000156475 PPP2R2B -4.99 -8.22 2.00E-06 4.80E-04 ENSG00000115457 IGFBP2 5.3 8.21 2.00E-06 4.80E-04 ENSG00000221963 APOL6 6.84 8.2 2.00E-06 4.80E-04 ENSG00000108691 CCL2 8.4 8.18 2.10E-06 4.90E-04 ENSG00000091972 CD200 -3.16 -8.06 2.50E-06 5.60E-04 ENSG00000072422 RHOBTB1 3.74 8.04 2.50E-06 5.60E-04 ENSG00000105854 PON2 3.91 8.03 2.50E-06 5.60E-04 ENSG00000140262 TCF12 2.64 8 2.70E-06 5.80E-04 ENSG00000142875 PRKACB -2.27 -7.97 2.80E-06 5.90E-04 ENSG00000181790 BAI1 -7.06 -7.9 3.10E-06 6.30E-04 ENSG00000091428 RAPGEF4 -7.17 -7.89 3.10E-06 6.30E-04 ENSG00000147485 PXDNL 9.39 7.88 3.10E-06 6.30E-04 ENSG00000139832 RAB20 5.13 7.88 3.10E-06 6.30E-04 ENSG00000185275 CD24P4 -3.16 -7.87 3.20E-06 6.30E-04 ENSG00000157064 NMNAT2 -6.48 -7.8 3.50E-06 6.80E-04 ENSG00000171408 PDE7B 7.15 7.78 3.60E-06 6.80E-04 ENSG00000132561 MATN2 10.77 7.77 3.60E-06 6.80E-04

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000196660 SLC30A10 -6.82 -7.76 3.70E-06 6.80E-04 ENSG00000143061 IGSF3 -2.7 -7.76 3.70E-06 6.80E-04 ENSG00000162512 SDC3 -3.66 -7.75 3.70E-06 6.80E-04 ENSG00000127990 SGCE 2.67 7.71 3.90E-06 7.10E-04 ENSG00000149090 PAMR1 -12.38 -7.63 4.40E-06 7.70E-04 ENSG00000147852 VLDLR -3.69 -7.63 4.40E-06 7.70E-04 ENSG00000173848 NET1 4.93 7.63 4.40E-06 7.70E-04 ENSG00000152092 ASTN1 -7.11 -7.61 4.60E-06 7.80E-04 ENSG00000152503 TRIM36 -4.41 -7.6 4.60E-06 7.80E-04 ENSG00000131459 GFPT2 4.86 7.58 4.80E-06 7.80E-04 ENSG00000171714 ANO5 -6.34 -7.57 4.80E-06 7.80E-04 ENSG00000105894 PTN 6.26 7.57 4.80E-06 7.80E-04 ENSG00000009413 REV3L -3.29 -7.57 4.80E-06 7.80E-04 ENSG00000149294 NCAM1 -6.12 -7.55 4.90E-06 7.80E-04 ENSG00000217236 SP9 -7.8 -7.55 5.00E-06 7.80E-04 ENSG00000135525 MAP7 -6.09 -7.51 5.20E-06 8.10E-04 ENSG00000164823 OSGIN2 2.62 7.5 5.30E-06 8.10E-04 ENSG00000237412 . 10.48 7.49 5.30E-06 8.10E-04 ENSG00000164300 SERINC5 -4.51 -7.49 5.40E-06 8.10E-04 ENSG00000009694 TENM1 -5.3 -7.48 5.40E-06 8.10E-04 ENSG00000164070 HSPA4L 2.59 7.48 5.50E-06 8.10E-04 ENSG00000109861 CTSC 8.21 7.45 5.70E-06 8.40E-04 ENSG00000154678 PDE1C 6.2 7.42 5.90E-06 8.40E-04 ENSG00000137558 PI15 -4.45 -7.41 6.00E-06 8.40E-04 ENSG00000106236 NPTX2 -8.2 -7.41 6.00E-06 8.40E-04 ENSG00000114646 CSPG5 -4.02 -7.4 6.10E-06 8.40E-04 ENSG00000197410 DCHS2 -4.81 -7.4 6.10E-06 8.40E-04 ENSG00000171551 ECEL1 7.22 7.39 6.20E-06 8.50E-04 ENSG00000138207 RBP4 7.29 7.38 6.20E-06 8.50E-04 ENSG00000057294 PKP2 -6.56 -7.38 6.30E-06 8.50E-04 ENSG00000176903 PNMA1 -2.04 -7.36 6.40E-06 8.50E-04 ENSG00000139946 PELI2 -3.26 -7.36 6.40E-06 8.50E-04 ENSG00000253661 ZFHX4-AS1 -5.13 -7.35 6.50E-06 8.60E-04 ENSG00000171004 HS6ST2 -4.97 -7.33 6.80E-06 8.80E-04 ENSG00000233901 . 6.23 7.31 6.90E-06 8.90E-04 ENSG00000155629 PIK3AP1 -7 -7.3 7.00E-06 8.90E-04 ENSG00000230825 . 7.01 7.29 7.10E-06 8.90E-04 ENSG00000125414 MYH2 -13.17 -7.29 7.20E-06 8.90E-04 ENSG00000160691 SHC1 4.17 7.28 7.20E-06 8.90E-04

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000123130 ACOT9 3.05 7.24 7.60E-06 9.20E-04 ENSG00000159403 C1R 8.97 7.24 7.60E-06 9.20E-04 ENSG00000188674 C2orf80 4.96 7.24 7.60E-06 9.20E-04 ENSG00000170412 GPRC5C -8.79 -7.22 7.80E-06 9.40E-04 ENSG00000172260 NEGR1 -4.13 -7.19 8.10E-06 9.70E-04 ENSG00000144815 NXPE3 2.31 7.19 8.20E-06 9.70E-04 ENSG00000126878 AIF1L 5.53 7.17 8.50E-06 9.90E-04 ENSG00000135903 PAX3 11.66 7.16 8.60E-06 9.90E-04 ENSG00000152268 SPON1 -3.66 -7.15 8.70E-06 9.90E-04 ENSG00000185559 DLK1 8.28 7.13 8.90E-06 1.00E-03 ENSG00000155660 PDIA4 1.78 7.13 8.90E-06 1.00E-03 ENSG00000100968 NFATC4 3.9 7.12 9.00E-06 1.00E-03 ENSG00000266045 . 7.79 7.11 9.20E-06 1.00E-03 ENSG00000134291 TMEM106C 2.72 7.1 9.40E-06 1.00E-03 ENSG00000166206 GABRB3 -5.08 -7.09 9.50E-06 1.00E-03 ENSG00000170579 DLGAP1 -4.89 -7.09 9.50E-06 1.00E-03 ENSG00000166265 CYYR1 -5.45 -7.08 9.60E-06 1.00E-03 ENSG00000188158 NHS 3.79 7.06 9.90E-06 1.10E-03 ENSG00000179909 ZNF154 4.99 7.02 1.10E-05 1.10E-03 ENSG00000146376 ARHGAP18 4.81 7 1.10E-05 1.10E-03 ENSG00000153404 PLEKHG4B 4.14 7 1.10E-05 1.10E-03 ENSG00000242265 PEG10 4.71 6.99 1.10E-05 1.10E-03 ENSG00000165197 FIGF 9.2 6.98 1.10E-05 1.10E-03 ENSG00000183691 NOG -8.43 -6.97 1.10E-05 1.10E-03 ENSG00000152377 SPOCK1 -5.26 -6.96 1.10E-05 1.10E-03 ENSG00000124479 NDP 6.42 6.95 1.20E-05 1.10E-03 ENSG00000171723 GPHN -2.81 -6.95 1.20E-05 1.10E-03 ENSG00000135318 NT5E 5.47 6.95 1.20E-05 1.10E-03 ENSG00000113263 ITK 6.39 6.95 1.20E-05 1.10E-03 ENSG00000249430 . 4.74 6.95 1.20E-05 1.10E-03 ENSG00000078098 FAP 9.43 6.92 1.20E-05 1.20E-03 ENSG00000204967 PCDHA4 -3.57 -6.91 1.20E-05 1.20E-03 ENSG00000092345 DAZL -14.48 -6.91 1.20E-05 1.20E-03 ENSG00000236197 . 8.8 6.89 1.30E-05 1.20E-03 ENSG00000166123 GPT2 -5.04 -6.89 1.30E-05 1.20E-03 ENSG00000118508 RAB32 9.47 6.89 1.30E-05 1.20E-03 ENSG00000205413 SAMD9 4.8 6.88 1.30E-05 1.20E-03 ENSG00000123119 NECAB1 -3.12 -6.88 1.30E-05 1.20E-03 ENSG00000072858 SIDT1 -6.6 -6.87 1.30E-05 1.20E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000127870 RNF6 1.24 4.15 1.20E-03 2.00E-02 ENSG00000163686 ABHD6 -2.62 -4.15 1.20E-03 2.00E-02 ENSG00000102409 BEX4 -1.01 -4.14 1.20E-03 2.00E-02 ENSG00000136542 GALNT5 6.81 4.14 1.20E-03 2.00E-02 ENSG00000196547 MAN2A2 -2.6 -4.14 1.20E-03 2.00E-02 ENSG00000064961 HMG20B 1.48 4.14 1.20E-03 2.00E-02 ENSG00000198155 ZNF876P 4.42 4.14 1.20E-03 2.00E-02 ENSG00000156869 FRRS1 3.37 4.13 1.20E-03 2.00E-02 ENSG00000114770 ABCC5 -1.78 -4.13 1.30E-03 2.00E-02 ENSG00000116489 CAPZA1 1.51 4.13 1.30E-03 2.00E-02 ENSG00000132692 BCAN -6.43 -4.13 1.30E-03 2.00E-02 ENSG00000139182 CLSTN3 -2.21 -4.13 1.30E-03 2.00E-02 ENSG00000162576 MXRA8 3.95 4.13 1.30E-03 2.00E-02 ENSG00000230124 . -3.91 -4.13 1.30E-03 2.00E-02 ENSG00000068615 REEP1 -3.06 -4.13 1.30E-03 2.00E-02 ENSG00000214944 ARHGEF28 -5.98 -4.13 1.30E-03 2.00E-02 ENSG00000109738 GLRB -3.06 -4.12 1.30E-03 2.00E-02 ENSG00000091664 SLC17A6 -4.75 -4.12 1.30E-03 2.00E-02 ENSG00000114670 NEK11 7.19 4.12 1.30E-03 2.00E-02 ENSG00000233608 TWIST2 10.14 4.12 1.30E-03 2.00E-02 ENSG00000176383 B3GNT4 -2.8 -4.12 1.30E-03 2.00E-02 ENSG00000132793 LPIN3 6.04 4.11 1.30E-03 2.00E-02 ENSG00000177363 LRRN4CL 4.95 4.11 1.30E-03 2.10E-02 ENSG00000163909 HEYL 7.84 4.11 1.30E-03 2.10E-02 ENSG00000198598 MMP17 4.05 4.11 1.30E-03 2.10E-02 ENSG00000125285 SOX21 -3.1 -4.11 1.30E-03 2.10E-02 ENSG00000198914 POU3F3 2.31 4.11 1.30E-03 2.10E-02 ENSG00000198324 FAM109A 2.15 4.11 1.30E-03 2.10E-02 ENSG00000166801 FAM111A 1.9 4.11 1.30E-03 2.10E-02 ENSG00000141756 FKBP10 2.7 4.1 1.30E-03 2.10E-02 ENSG00000185838 GNB1L -3.24 -4.1 1.30E-03 2.10E-02 ENSG00000158019 BRE 2.31 4.1 1.30E-03 2.10E-02 ENSG00000197299 BLM 4.57 4.1 1.30E-03 2.10E-02 ENSG00000114850 SSR3 2.01 4.1 1.30E-03 2.10E-02 ENSG00000233639 . 3.15 4.1 1.30E-03 2.10E-02 ENSG00000173208 ABCD2 -4.31 -4.1 1.30E-03 2.10E-02 ENSG00000246430 . 13.76 4.09 1.30E-03 2.10E-02 ENSG00000132359 RAP1GAP2 -3.66 -4.09 1.30E-03 2.10E-02 ENSG00000185920 PTCH1 -4.78 -4.09 1.30E-03 2.10E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000224078 SNHG14 -2.38 -4.09 1.30E-03 2.10E-02 ENSG00000106366 SERPINE1 4.09 4.09 1.30E-03 2.10E-02 ENSG00000204186 ZDBF2 -1.84 -4.09 1.30E-03 2.10E-02 ENSG00000187017 ESPN 8.22 4.09 1.30E-03 2.10E-02 ENSG00000006432 MAP3K9 -2.12 -4.09 1.40E-03 2.10E-02 ENSG00000127955 GNAI1 -1.52 -4.09 1.40E-03 2.10E-02 ENSG00000206538 VGLL3 7.62 4.09 1.40E-03 2.10E-02 ENSG00000204706 . 2.98 4.08 1.40E-03 2.10E-02 ENSG00000002016 RAD52 -1.68 -4.08 1.40E-03 2.10E-02 ENSG00000109814 UGDH 2.42 4.08 1.40E-03 2.10E-02 ENSG00000129646 QRICH2 -2.56 -4.08 1.40E-03 2.10E-02 ENSG00000165757 KIAA1462 -2.1 -4.08 1.40E-03 2.10E-02 ENSG00000120087 HOXB7 -8.81 -4.08 1.40E-03 2.10E-02 ENSG00000135862 LAMC1 3.33 4.08 1.40E-03 2.10E-02 ENSG00000166106 ADAMTS15 -4.77 -4.07 1.40E-03 2.10E-02 ENSG00000073464 CLCN4 -1.84 -4.07 1.40E-03 2.10E-02 ENSG00000038382 TRIO -1.84 -4.07 1.40E-03 2.10E-02 ENSG00000179761 PIPOX -2.96 -4.07 1.40E-03 2.10E-02 ENSG00000182319 . -4.61 -4.07 1.40E-03 2.10E-02 ENSG00000115183 TANC1 1.4 4.07 1.40E-03 2.10E-02 ENSG00000138814 PPP3CA -1.24 -4.07 1.40E-03 2.10E-02 ENSG00000042062 FAM65C 3.57 4.07 1.40E-03 2.10E-02 ENSG00000185219 ZNF445 -1.29 -4.07 1.40E-03 2.10E-02 ENSG00000139352 ASCL1 -4.89 -4.06 1.40E-03 2.20E-02 ENSG00000164318 EGFLAM 8.69 4.06 1.40E-03 2.20E-02 ENSG00000245149 . -2.13 -4.06 1.40E-03 2.20E-02 ENSG00000170989 S1PR1 -5.22 -4.06 1.40E-03 2.20E-02 ENSG00000068796 KIF2A -1.21 -4.05 1.40E-03 2.20E-02 ENSG00000164294 GPX8 5.14 4.05 1.40E-03 2.20E-02 ENSG00000167553 TUBA1C 3.24 4.05 1.50E-03 2.20E-02 ENSG00000104381 GDAP1 -1.48 -4.05 1.50E-03 2.20E-02 ENSG00000154096 THY1 3.45 4.05 1.50E-03 2.20E-02 ENSG00000173457 PPP1R14B 2.23 4.05 1.50E-03 2.20E-02 ENSG00000140564 FURIN 1.88 4.04 1.50E-03 2.20E-02 ENSG00000162981 FAM84A -4.28 -4.04 1.50E-03 2.20E-02 ENSG00000183856 IQGAP3 3.58 4.04 1.50E-03 2.20E-02 ENSG00000091136 LAMB1 3.85 4.04 1.50E-03 2.20E-02 ENSG00000188153 COL4A5 2.19 4.04 1.50E-03 2.20E-02 ENSG00000101150 TPD52L2 1.16 4.04 1.50E-03 2.20E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000116574 RHOU 5.16 4.04 1.50E-03 2.20E-02 ENSG00000131435 PDLIM4 1.88 4.03 1.50E-03 2.20E-02 ENSG00000125868 DSTN -0.9 -4.03 1.50E-03 2.20E-02 ENSG00000188707 C7orf29 -4.52 -4.03 1.50E-03 2.20E-02 ENSG00000107829 FBXW4 4.13 4.03 1.50E-03 2.20E-02 ENSG00000076242 MLH1 1.32 4.03 1.50E-03 2.20E-02 ENSG00000174943 KCTD13 -2.05 -4.03 1.50E-03 2.20E-02 ENSG00000105856 HBP1 1.98 4.03 1.50E-03 2.20E-02 ENSG00000011465 DCN 12.5 4.02 1.50E-03 2.30E-02 ENSG00000240065 PSMB9 4.42 4.02 1.50E-03 2.30E-02 ENSG00000117569 PTBP2 -1.74 -4.02 1.50E-03 2.30E-02 ENSG00000233593 . 4.66 4.02 1.50E-03 2.30E-02 ENSG00000157227 MMP14 6.71 4.01 1.50E-03 2.30E-02 ENSG00000138758 11-Sep 1.91 4.01 1.60E-03 2.30E-02 ENSG00000113389 NPR3 8.96 4.01 1.60E-03 2.30E-02 ENSG00000141569 TRIM65 2.53 4 1.60E-03 2.30E-02 ENSG00000111801 BTN3A3 2.28 4 1.60E-03 2.30E-02 ENSG00000165633 VSTM4 -2.6 -4 1.60E-03 2.30E-02 ENSG00000206527 PTPLB -1.35 -4 1.60E-03 2.30E-02 ENSG00000241015 TPM3P9 -3.08 -4 1.60E-03 2.30E-02 ENSG00000138641 HERC3 -2.22 -4 1.60E-03 2.30E-02 ENSG00000165806 CASP7 2.76 4 1.60E-03 2.30E-02 ENSG00000128923 FAM63B -1.24 -4 1.60E-03 2.30E-02 ENSG00000049860 HEXB 2.02 4 1.60E-03 2.30E-02 ENSG00000177707 PVRL3 1.32 4 1.60E-03 2.30E-02 ENSG00000181704 YIPF6 1.17 4 1.60E-03 2.30E-02 ENSG00000173705 SUSD5 4.7 4 1.60E-03 2.30E-02 ENSG00000144218 AFF3 -2.65 -4 1.60E-03 2.30E-02 ENSG00000181019 NQO1 3.98 4 1.60E-03 2.30E-02 ENSG00000197712 FAM114A1 3.56 3.99 1.60E-03 2.30E-02 ENSG00000108578 BLMH 1.32 3.99 1.60E-03 2.30E-02 ENSG00000133069 TMCC2 -2.53 -3.99 1.60E-03 2.30E-02 ENSG00000152117 . -2.43 -3.99 1.60E-03 2.30E-02 ENSG00000143387 CTSK 7.16 3.99 1.60E-03 2.30E-02 ENSG00000120820 GLT8D2 5.66 3.99 1.60E-03 2.30E-02 ENSG00000117289 TXNIP 3.1 3.99 1.60E-03 2.30E-02 ENSG00000166130 IKBIP 2.24 3.99 1.60E-03 2.30E-02 ENSG00000173611 SCAI -2.57 -3.98 1.60E-03 2.30E-02 ENSG00000152217 SETBP1 2.96 3.98 1.60E-03 2.30E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000103202 NME4 2.01 3.98 1.60E-03 2.30E-02 ENSG00000073605 GSDMB -2.54 -3.98 1.70E-03 2.40E-02 ENSG00000153363 LINC00467 2.92 3.98 1.70E-03 2.40E-02 ENSG00000175898 S1PR2 4.77 3.98 1.70E-03 2.40E-02 ENSG00000019549 SNAI2 8.54 3.97 1.70E-03 2.40E-02 ENSG00000246203 . -3.64 -3.97 1.70E-03 2.40E-02 ENSG00000179912 R3HDM2 -1.96 -3.97 1.70E-03 2.40E-02 ENSG00000138336 TET1 -2.13 -3.97 1.70E-03 2.40E-02 ENSG00000121057 AKAP1 -3.07 -3.97 1.70E-03 2.40E-02 ENSG00000112769 LAMA4 5.34 3.97 1.70E-03 2.40E-02 ENSG00000154783 FGD5 -10.23 -3.96 1.70E-03 2.40E-02 ENSG00000184254 ALDH1A3 9.38 3.96 1.70E-03 2.40E-02 ENSG00000144591 GMPPA 1.77 3.96 1.70E-03 2.40E-02 ENSG00000119638 NEK9 1.16 3.96 1.70E-03 2.40E-02 ENSG00000031081 ARHGAP31 2.3 3.96 1.70E-03 2.40E-02 ENSG00000175832 ETV4 3.55 3.96 1.70E-03 2.40E-02 ENSG00000109832 DDX25 -2.59 -3.96 1.70E-03 2.40E-02 ENSG00000198853 RUSC2 -2.51 -3.96 1.70E-03 2.40E-02 ENSG00000143341 HMCN1 8.98 3.96 1.70E-03 2.40E-02 ENSG00000170166 HOXD4 -6.87 -3.95 1.70E-03 2.40E-02 ENSG00000147065 MSN 1.43 3.95 1.70E-03 2.40E-02 ENSG00000101608 MYL12A 2.62 3.95 1.70E-03 2.40E-02 ENSG00000113361 CDH6 -4.07 -3.95 1.70E-03 2.40E-02 ENSG00000121966 CXCR4 2.68 3.95 1.70E-03 2.40E-02 ENSG00000005700 IBTK 1.5 3.95 1.70E-03 2.40E-02 ENSG00000114631 PODXL2 -3.1 -3.95 1.70E-03 2.40E-02 ENSG00000161513 FDXR 2.79 3.95 1.80E-03 2.40E-02 ENSG00000114805 PLCH1 2.04 3.95 1.80E-03 2.40E-02 ENSG00000143369 ECM1 5.19 3.95 1.80E-03 2.40E-02 ENSG00000173926 3-Mar -2.77 -3.95 1.80E-03 2.40E-02 ENSG00000118473 SGIP1 -2.91 -3.94 1.80E-03 2.40E-02 ENSG00000002586 CD99 -1.35 -3.94 1.80E-03 2.40E-02 ENSG00000129682 FGF13 -3.7 -3.94 1.80E-03 2.40E-02 ENSG00000119699 TGFB3 4.53 3.94 1.80E-03 2.50E-02 ENSG00000123485 HJURP 3.5 3.94 1.80E-03 2.50E-02 ENSG00000149970 CNKSR2 -3.49 -3.94 1.80E-03 2.50E-02 ENSG00000142634 EFHD2 2.67 3.93 1.80E-03 2.50E-02 ENSG00000229971 . 3.67 3.93 1.80E-03 2.50E-02 ENSG00000072682 P4HA2 5.27 3.93 1.80E-03 2.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000113328 CCNG1 2.33 3.93 1.80E-03 2.50E-02 ENSG00000070193 FGF10 9.72 3.93 1.80E-03 2.50E-02 ENSG00000182050 MGAT4C -4.27 -3.92 1.80E-03 2.50E-02 ENSG00000122952 ZWINT 3.08 3.92 1.80E-03 2.50E-02 ENSG00000163191 S100A11 6.59 3.92 1.90E-03 2.50E-02 ENSG00000230630 DNM3OS 8.92 3.92 1.90E-03 2.50E-02 ENSG00000099256 PRTFDC1 3.25 3.92 1.90E-03 2.50E-02 ENSG00000173281 PPP1R3B 2.56 3.92 1.90E-03 2.50E-02 ENSG00000150760 DOCK1 1.26 3.92 1.90E-03 2.50E-02 ENSG00000196205 EEF1A1P5 1.69 3.91 1.90E-03 2.50E-02 ENSG00000160014 CALM3 -1.31 -3.91 1.90E-03 2.50E-02 ENSG00000005243 COPZ2 6.44 3.91 1.90E-03 2.60E-02 ENSG00000156299 TIAM1 2.06 3.91 1.90E-03 2.60E-02 ENSG00000139324 TMTC3 1.44 3.91 1.90E-03 2.60E-02 ENSG00000121064 SCPEP1 1.9 3.91 1.90E-03 2.60E-02 ENSG00000145734 BDP1 -1.01 -3.9 1.90E-03 2.60E-02 ENSG00000143367 TUFT1 -2.48 -3.9 1.90E-03 2.60E-02 ENSG00000156140 ADAMTS3 2.54 3.9 1.90E-03 2.60E-02 ENSG00000089472 HEPH 3.81 3.9 1.90E-03 2.60E-02 ENSG00000056972 TRAF3IP2 -2.34 -3.9 1.90E-03 2.60E-02 ENSG00000152969 JAKMIP1 -3.71 -3.9 1.90E-03 2.60E-02 ENSG00000123096 SSPN 2.22 3.89 1.90E-03 2.60E-02 ENSG00000146540 1.44 3.89 1.90E-03 2.60E-02 ENSG00000148400 NOTCH1 -2.8 -3.89 2.00E-03 2.60E-02 ENSG00000135046 ANXA1 3.38 3.89 2.00E-03 2.60E-02 ENSG00000119711 ALDH6A1 -1.72 -3.88 2.00E-03 2.70E-02 ENSG00000197375 SLC22A5 2.69 3.88 2.00E-03 2.70E-02 ENSG00000261520 DLGAP1-AS5 -5.17 -3.88 2.00E-03 2.70E-02 ENSG00000151233 GXYLT1 1.89 3.88 2.00E-03 2.70E-02 ENSG00000169093 ASMTL 2.06 3.88 2.00E-03 2.70E-02 ENSG00000125520 SLC2A4RG 2.16 3.88 2.00E-03 2.70E-02 ENSG00000087494 PTHLH -6.05 -3.88 2.00E-03 2.70E-02 ENSG00000105983 LMBR1 -1.22 -3.87 2.00E-03 2.70E-02 ENSG00000187764 SEMA4D -2.71 -3.87 2.00E-03 2.70E-02 ENSG00000160305 DIP2A -1.4 -3.87 2.00E-03 2.70E-02 ENSG00000222687 . -2.88 -3.87 2.00E-03 2.70E-02 ENSG00000138160 KIF11 2.57 3.86 2.00E-03 2.70E-02 ENSG00000112137 PHACTR1 -4.98 -3.86 2.10E-03 2.70E-02 ENSG00000149571 KIRREL3 3.94 3.86 2.10E-03 2.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000121281 ADCY7 -2.96 -3.86 2.10E-03 2.70E-02 ENSG00000172053 QARS 1.03 3.86 2.10E-03 2.70E-02 ENSG00000007237 GAS7 -1.87 -3.86 2.10E-03 2.70E-02 ENSG00000197406 DIO3 5.41 3.86 2.10E-03 2.80E-02 ENSG00000162976 PQLC3 3.2 3.85 2.10E-03 2.80E-02 ENSG00000171992 SYNPO 2.29 3.85 2.10E-03 2.80E-02 ENSG00000013810 TACC3 2.75 3.85 2.10E-03 2.80E-02 ENSG00000134330 IAH1 5.01 3.85 2.10E-03 2.80E-02 ENSG00000146112 PPP1R18 1.51 3.85 2.10E-03 2.80E-02 ENSG00000179813 FAM216B -8.24 -3.85 2.10E-03 2.80E-02 ENSG00000115414 FN1 4.19 3.85 2.10E-03 2.80E-02 ENSG00000128487 SPECC1 -2.17 -3.85 2.10E-03 2.80E-02 ENSG00000086696 HSD17B2 10.99 3.85 2.10E-03 2.80E-02 ENSG00000129675 ARHGEF6 -3.21 -3.84 2.10E-03 2.80E-02 ENSG00000139990 DCAF5 -1.19 -3.84 2.10E-03 2.80E-02 ENSG00000024526 DEPDC1 3.35 3.84 2.10E-03 2.80E-02 ENSG00000198948 MFAP3L -2.88 -3.84 2.10E-03 2.80E-02 ENSG00000112406 HECA -1.8 -3.84 2.10E-03 2.80E-02 ENSG00000114738 MAPKAPK3 1.54 3.84 2.20E-03 2.80E-02 ENSG00000083814 ZNF671 4.66 3.84 2.20E-03 2.80E-02 ENSG00000196781 TLE1 2.41 3.83 2.20E-03 2.80E-02 ENSG00000099875 MKNK2 2.26 3.83 2.20E-03 2.80E-02 ENSG00000130714 POMT1 -1.46 -3.83 2.20E-03 2.80E-02 ENSG00000065054 SLC9A3R2 3.13 3.83 2.20E-03 2.80E-02 ENSG00000184500 PROS1 1.67 3.83 2.20E-03 2.80E-02 ENSG00000204262 COL5A2 3.33 3.83 2.20E-03 2.80E-02 ENSG00000184845 DRD1 -5.63 -3.83 2.20E-03 2.80E-02 ENSG00000076641 PAG1 2.27 3.83 2.20E-03 2.80E-02 ENSG00000144596 GRIP2 -5.86 -3.83 2.20E-03 2.80E-02 ENSG00000162552 WNT4 -4.49 -3.83 2.20E-03 2.80E-02 ENSG00000056736 IL17RB 2.73 3.82 2.20E-03 2.80E-02 ENSG00000182742 HOXB4 -9.78 -3.82 2.20E-03 2.80E-02 ENSG00000079931 MOXD1 -6.1 -3.82 2.20E-03 2.80E-02 ENSG00000155096 AZIN1 -1.21 -3.82 2.20E-03 2.80E-02 ENSG00000134317 GRHL1 -2.7 -3.82 2.20E-03 2.80E-02 ENSG00000105552 BCAT2 2.35 3.82 2.20E-03 2.80E-02 ENSG00000071073 MGAT4A -2.72 -3.82 2.20E-03 2.90E-02 ENSG00000169762 TAPT1 -1.41 -3.82 2.20E-03 2.90E-02 ENSG00000160801 PTH1R 5.92 3.82 2.20E-03 2.90E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000186231 KLHL32 -4.27 -3.58 3.50E-03 3.70E-02 ENSG00000185513 L3MBTL1 -2.96 -3.58 3.50E-03 3.70E-02 ENSG00000119950 MXI1 -2.88 -3.58 3.50E-03 3.70E-02 ENSG00000010704 HFE 4.74 3.58 3.50E-03 3.70E-02 ENSG00000175274 TP53I11 -2.93 -3.58 3.50E-03 3.70E-02 ENSG00000101871 MID1 1.87 3.58 3.50E-03 3.70E-02 ENSG00000152078 TMEM56 -2.89 -3.58 3.50E-03 3.70E-02 ENSG00000007516 BAIAP3 2.49 3.58 3.50E-03 3.70E-02 ENSG00000141540 TTYH2 -2.87 -3.58 3.50E-03 3.70E-02 ENSG00000118292 C1orf54 2.37 3.58 3.50E-03 3.70E-02 ENSG00000063438 AHRR 2.92 3.57 3.50E-03 3.70E-02 ENSG00000109805 NCAPG 2.97 3.57 3.50E-03 3.70E-02 ENSG00000162733 DDR2 3.19 3.57 3.50E-03 3.70E-02 ENSG00000203685 C1orf95 -3.51 -3.57 3.50E-03 3.70E-02 ENSG00000197329 PELI1 1.87 3.57 3.60E-03 3.70E-02 ENSG00000105223 PLD3 1.71 3.57 3.60E-03 3.70E-02 ENSG00000100065 CARD10 4.7 3.57 3.60E-03 3.70E-02 ENSG00000146374 RSPO3 -2.34 -3.57 3.60E-03 3.70E-02 ENSG00000066279 ASPM 2.62 3.57 3.60E-03 3.70E-02 ENSG00000005022 SLC25A5 1.31 3.57 3.60E-03 3.70E-02 ENSG00000145248 SLC10A4 4.34 3.57 3.60E-03 3.70E-02 ENSG00000181195 PENK 11.43 3.57 3.60E-03 3.70E-02 ENSG00000110076 NRXN2 -5.21 -3.56 3.60E-03 3.70E-02 ENSG00000255103 KIAA0754 2.39 3.56 3.60E-03 3.70E-02 ENSG00000120539 MASTL 1.77 3.56 3.60E-03 3.70E-02 ENSG00000077809 GTF2I -1.13 -3.56 3.60E-03 3.70E-02 ENSG00000163961 RNF168 1.35 3.56 3.60E-03 3.70E-02 ENSG00000106004 HOXA5 -10.27 -3.56 3.60E-03 3.70E-02 ENSG00000067191 CACNB1 -2.32 -3.56 3.60E-03 3.80E-02 ENSG00000157077 ZFYVE9 -1.01 -3.55 3.70E-03 3.80E-02 ENSG00000175874 CREG2 -4.75 -3.55 3.70E-03 3.80E-02 ENSG00000152558 TMEM123 -1.24 -3.55 3.70E-03 3.80E-02 ENSG00000162426 SLC45A1 -2.57 -3.55 3.70E-03 3.80E-02 ENSG00000150636 CCDC102B 2.76 3.55 3.70E-03 3.80E-02 ENSG00000076201 PTPN23 -2.37 -3.55 3.70E-03 3.80E-02 ENSG00000256463 SALL3 -10.75 -3.55 3.70E-03 3.80E-02 ENSG00000113739 STC2 4.29 3.55 3.70E-03 3.80E-02 ENSG00000111799 COL12A1 4.13 3.55 3.70E-03 3.80E-02 ENSG00000119596 . -1.37 -3.54 3.80E-03 3.80E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000124171 PARD6B -3.9 -3.54 3.80E-03 3.90E-02 ENSG00000101040 ZMYND8 -1.77 -3.54 3.80E-03 3.90E-02 ENSG00000196132 MYT1 -4.19 -3.54 3.80E-03 3.90E-02 ENSG00000159433 STARD9 -1.63 -3.54 3.80E-03 3.90E-02 ENSG00000050130 JKAMP 1.37 3.53 3.80E-03 3.90E-02 ENSG00000068971 PPP2R5B -1.51 -3.53 3.80E-03 3.90E-02 ENSG00000130475 FCHO1 -3.45 -3.53 3.80E-03 3.90E-02 ENSG00000179630 LACC1 4.44 3.53 3.80E-03 3.90E-02 ENSG00000139211 AMIGO2 -3.38 -3.53 3.80E-03 3.90E-02 ENSG00000065923 SLC9A7 -2.55 -3.53 3.80E-03 3.90E-02 ENSG00000155980 KIF5A -2.07 -3.53 3.80E-03 3.90E-02 ENSG00000159674 SPON2 5.28 3.53 3.90E-03 3.90E-02 ENSG00000198856 OSTC 2.29 3.53 3.90E-03 3.90E-02 ENSG00000139289 PHLDA1 2.01 3.53 3.90E-03 3.90E-02 ENSG00000183628 DGCR6 2.54 3.53 3.90E-03 3.90E-02 ENSG00000178996 SNX18 1.53 3.53 3.90E-03 3.90E-02 ENSG00000197837 HIST4H4 3.7 3.53 3.90E-03 3.90E-02 ENSG00000112419 PHACTR2 2.31 3.52 3.90E-03 3.90E-02 ENSG00000109113 RAB34 2.37 3.52 3.90E-03 3.90E-02 ENSG00000169299 PGM2 1.62 3.52 3.90E-03 3.90E-02 ENSG00000187720 THSD4 8.2 3.52 3.90E-03 3.90E-02 ENSG00000063015 SEZ6 -5.46 -3.52 3.90E-03 4.00E-02 ENSG00000196975 ANXA4 3.66 3.52 3.90E-03 4.00E-02 ENSG00000049759 NEDD4L -1.44 -3.52 3.90E-03 4.00E-02 ENSG00000115415 STAT1 1.04 3.52 4.00E-03 4.00E-02 ENSG00000083896 YTHDC1 -0.88 -3.51 4.00E-03 4.00E-02 ENSG00000106025 TSPAN12 -3.72 -3.51 4.00E-03 4.00E-02 ENSG00000110900 TSPAN11 1.81 3.51 4.00E-03 4.00E-02 ENSG00000143870 PDIA6 0.93 3.51 4.00E-03 4.00E-02 ENSG00000151150 ANK3 -3.22 -3.51 4.00E-03 4.00E-02 ENSG00000165650 PDZD8 -0.82 -3.51 4.00E-03 4.00E-02 ENSG00000100842 EFS 2.49 3.51 4.00E-03 4.00E-02 ENSG00000056487 PHF21B 1.87 3.51 4.00E-03 4.00E-02 ENSG00000064042 LIMCH1 -3.05 -3.51 4.00E-03 4.00E-02 ENSG00000068489 PRR11 1.67 3.51 4.00E-03 4.00E-02 ENSG00000196639 HRH1 5.39 3.51 4.00E-03 4.00E-02 ENSG00000105996 HOXA2 -4.86 -3.51 4.00E-03 4.00E-02 ENSG00000187815 ZNF642 -2.19 -3.51 4.00E-03 4.00E-02 ENSG00000135932 CAB39 -0.84 -3.5 4.00E-03 4.00E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000128228 SDF2L1 2.4 3.47 4.30E-03 4.20E-02 ENSG00000167074 TEF 2.47 3.47 4.30E-03 4.20E-02 ENSG00000106688 SLC1A1 -3.02 -3.47 4.30E-03 4.20E-02 ENSG00000139734 DIAPH3 3.88 3.47 4.30E-03 4.20E-02 ENSG00000172175 MALT1 1.56 3.47 4.30E-03 4.20E-02 ENSG00000161671 EMC10 1.4 3.47 4.30E-03 4.20E-02 ENSG00000215897 ZBTB8B -2.64 -3.47 4.30E-03 4.20E-02 ENSG00000073584 SMARCE1 0.96 3.46 4.40E-03 4.20E-02 ENSG00000075218 GTSE1 2.47 3.46 4.40E-03 4.20E-02 ENSG00000197496 SLC2A10 1.79 3.46 4.40E-03 4.20E-02 ENSG00000120708 TGFBI 8.18 3.46 4.40E-03 4.20E-02 ENSG00000205268 PDE7A -1.49 -3.46 4.40E-03 4.20E-02 ENSG00000163531 NFASC -3.42 -3.46 4.40E-03 4.20E-02 ENSG00000121904 CSMD2 -7 -3.46 4.40E-03 4.20E-02 ENSG00000148834 GSTO1 1.81 3.46 4.40E-03 4.20E-02 ENSG00000172292 CERS6 -1.84 -3.46 4.40E-03 4.20E-02 ENSG00000081181 ARG2 -2.22 -3.46 4.40E-03 4.20E-02 ENSG00000166734 CASC4 -1.28 -3.46 4.40E-03 4.20E-02 ENSG00000174010 KLHL15 1.33 3.46 4.40E-03 4.20E-02 ENSG00000130813 C19orf66 1.62 3.46 4.40E-03 4.20E-02 ENSG00000197429 IPP 1.78 3.46 4.40E-03 4.20E-02 ENSG00000087258 GNAO1 -4.11 -3.46 4.40E-03 4.20E-02 ENSG00000164056 SPRY1 3.25 3.45 4.40E-03 4.20E-02 ENSG00000120800 UTP20 1.24 3.45 4.40E-03 4.20E-02 ENSG00000106524 ANKMY2 -1.07 -3.45 4.40E-03 4.20E-02 ENSG00000115486 GGCX 1.07 3.45 4.50E-03 4.20E-02 ENSG00000117481 NSUN4 1.46 3.45 4.50E-03 4.20E-02 ENSG00000123124 WWP1 -1.57 -3.45 4.50E-03 4.20E-02 ENSG00000154099 DNAAF1 -3.62 -3.45 4.50E-03 4.30E-02 ENSG00000105855 ITGB8 -3.51 -3.45 4.50E-03 4.30E-02 ENSG00000168824 . -3.45 -3.45 4.50E-03 4.30E-02 ENSG00000133121 STARD13 2.01 3.45 4.50E-03 4.30E-02 ENSG00000183281 PLGLB1 -3.71 -3.44 4.50E-03 4.30E-02 ENSG00000156298 TSPAN7 -2.61 -3.44 4.50E-03 4.30E-02 ENSG00000100027 YPEL1 -1.58 -3.44 4.50E-03 4.30E-02 ENSG00000142686 C1orf216 4.19 3.44 4.60E-03 4.30E-02 ENSG00000180440 SERTM1 3.42 3.44 4.60E-03 4.30E-02 ENSG00000053371 AKR7A2 1.29 3.44 4.60E-03 4.30E-02 ENSG00000101680 LAMA1 -1.21 -3.44 4.60E-03 4.30E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000164951 PDP1 1.68 3.43 4.60E-03 4.30E-02 ENSG00000196176 HIST1H4A 2.95 3.43 4.60E-03 4.30E-02 ENSG00000167528 ZNF641 -1.25 -3.43 4.60E-03 4.30E-02 ENSG00000248334 WHAMMP2 -2.54 -3.43 4.60E-03 4.30E-02 ENSG00000237649 KIFC1 2.51 3.43 4.60E-03 4.30E-02 ENSG00000006757 PNPLA4 4.82 3.43 4.70E-03 4.40E-02 ENSG00000176749 CDK5R1 -3.25 -3.43 4.70E-03 4.40E-02 ENSG00000091986 CCDC80 1.5 3.43 4.70E-03 4.40E-02 ENSG00000235471 . 1.61 3.43 4.70E-03 4.40E-02 ENSG00000102606 ARHGEF7 -1.15 -3.43 4.70E-03 4.40E-02 ENSG00000249242 TMEM150C -2.53 -3.43 4.70E-03 4.40E-02 ENSG00000116396 KCNC4 -4.13 -3.42 4.70E-03 4.40E-02 ENSG00000111058 ACSS3 6.06 3.42 4.70E-03 4.40E-02 ENSG00000198400 NTRK1 8.32 3.42 4.70E-03 4.40E-02 ENSG00000120129 DUSP1 3.36 3.42 4.70E-03 4.40E-02 ENSG00000185483 ROR1 4.67 3.42 4.70E-03 4.40E-02 ENSG00000246922 UBAP1L -2.71 -3.42 4.70E-03 4.40E-02 ENSG00000164124 TMEM144 3.27 3.42 4.70E-03 4.40E-02 ENSG00000180537 RNF182 2.63 3.42 4.70E-03 4.40E-02 ENSG00000152583 SPARCL1 -5.07 -3.42 4.80E-03 4.40E-02 ENSG00000180354 C7orf41 -1.62 -3.42 4.80E-03 4.40E-02 ENSG00000134909 ARHGAP32 -1.69 -3.41 4.80E-03 4.40E-02 ENSG00000138593 SECISBP2L -1.3 -3.41 4.80E-03 4.40E-02 ENSG00000048052 HDAC9 -2.57 -3.41 4.80E-03 4.40E-02 ENSG00000107968 MAP3K8 2.17 3.41 4.80E-03 4.40E-02 ENSG00000241644 INMT 4.5 3.41 4.80E-03 4.40E-02 ENSG00000157978 LDLRAP1 3.59 3.41 4.80E-03 4.40E-02 ENSG00000100034 PPM1F 1.55 3.41 4.80E-03 4.40E-02 ENSG00000156052 GNAQ -1.27 -3.41 4.80E-03 4.40E-02 ENSG00000163923 RPL39L 3.17 3.41 4.80E-03 4.40E-02 ENSG00000213190 MLLT11 -1.32 -3.41 4.80E-03 4.40E-02 ENSG00000180287 PLD5 -3.42 -3.41 4.80E-03 4.50E-02 ENSG00000162929 KIAA1841 -1.29 -3.41 4.80E-03 4.50E-02 ENSG00000169223 LMAN2 1.11 3.41 4.80E-03 4.50E-02 ENSG00000196139 AKR1C3 4.76 3.41 4.90E-03 4.50E-02 ENSG00000153310 FAM49B -1.13 -3.41 4.90E-03 4.50E-02 ENSG00000131944 C19orf40 2.74 3.41 4.90E-03 4.50E-02 ENSG00000129244 ATP1B2 -3.15 -3.4 4.90E-03 4.50E-02 ENSG00000120885 CLU 2 3.4 4.90E-03 4.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000187109 NAP1L1 1.73 3.4 4.90E-03 4.50E-02 ENSG00000182827 ACBD3 1.55 3.4 4.90E-03 4.50E-02 ENSG00000128973 CLN6 2.66 3.4 4.90E-03 4.50E-02 ENSG00000171502 COL24A1 2.58 3.4 4.90E-03 4.50E-02 ENSG00000169439 SDC2 1.18 3.4 4.90E-03 4.50E-02 ENSG00000161888 SPC24 3.11 3.4 4.90E-03 4.50E-02 ENSG00000167740 CYB5D2 1.6 3.4 4.90E-03 4.50E-02 ENSG00000201098 RNY1 -3.61 -3.4 4.90E-03 4.50E-02 ENSG00000077380 DYNC1I2 -0.77 -3.39 5.00E-03 4.50E-02 ENSG00000255248 . -2.21 -3.39 5.00E-03 4.50E-02 ENSG00000164930 FZD6 3.45 3.39 5.00E-03 4.50E-02 ENSG00000165943 MOAP1 -1.43 -3.39 5.00E-03 4.50E-02 ENSG00000003989 SLC7A2 4.76 3.39 5.00E-03 4.50E-02 ENSG00000151773 CCDC122 3.18 3.39 5.00E-03 4.50E-02 ENSG00000104774 MAN2B1 1.4 3.39 5.00E-03 4.50E-02 ENSG00000186862 PDZD7 -3.52 -3.39 5.00E-03 4.50E-02 ENSG00000158747 NBL1 5.05 3.39 5.00E-03 4.50E-02 ENSG00000085449 WDFY1 0.98 3.39 5.00E-03 4.50E-02 ENSG00000198794 SCAMP5 -1.66 -3.39 5.00E-03 4.50E-02 ENSG00000234969 . -2.62 -3.39 5.00E-03 4.50E-02 ENSG00000171033 PKIA -2.74 -3.39 5.00E-03 4.50E-02 ENSG00000164176 EDIL3 2.01 3.39 5.00E-03 4.50E-02 ENSG00000139269 INHBE 7.87 3.39 5.00E-03 4.50E-02 ENSG00000101126 ADNP -1.19 -3.39 5.00E-03 4.50E-02 ENSG00000163597 SNHG16 1.03 3.39 5.00E-03 4.50E-02 ENSG00000175161 CADM2 -2.38 -3.39 5.10E-03 4.60E-02 ENSG00000196391 ZNF774 -3.23 -3.39 5.10E-03 4.60E-02 ENSG00000151012 SLC7A11 2.98 3.38 5.10E-03 4.60E-02 ENSG00000258752 . -9.32 -3.38 5.10E-03 4.60E-02 ENSG00000156671 SAMD8 -1.23 -3.38 5.10E-03 4.60E-02 ENSG00000161298 ZNF382 -1.73 -3.38 5.10E-03 4.60E-02 ENSG00000148826 NKX6-2 3.65 3.38 5.10E-03 4.60E-02 ENSG00000160408 ST6GALNAC6 1.43 3.38 5.10E-03 4.60E-02 ENSG00000068024 HDAC4 2.49 3.38 5.10E-03 4.60E-02 ENSG00000141338 ABCA8 2.31 3.38 5.10E-03 4.60E-02 ENSG00000186635 ARAP1 1.33 3.38 5.10E-03 4.60E-02 ENSG00000161618 ALDH16A1 2.8 3.38 5.10E-03 4.60E-02 ENSG00000164220 F2RL2 7.67 3.38 5.10E-03 4.60E-02 ENSG00000133703 KRAS -1.12 -3.38 5.10E-03 4.60E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000079462 PAFAH1B3 -1.49 -3.38 5.10E-03 4.60E-02 ENSG00000151952 TMEM132D -6.52 -3.38 5.10E-03 4.60E-02 ENSG00000166295 ANAPC16 1.16 3.38 5.10E-03 4.60E-02 ENSG00000124140 SLC12A5 -5.4 -3.38 5.20E-03 4.60E-02 ENSG00000064687 ABCA7 -2.03 -3.37 5.20E-03 4.60E-02 ENSG00000179869 ABCA13 3.05 3.37 5.20E-03 4.60E-02 ENSG00000003147 ICA1 -3.01 -3.37 5.20E-03 4.60E-02 ENSG00000164889 SLC4A2 1.26 3.37 5.20E-03 4.60E-02 ENSG00000104415 WISP1 9.77 3.37 5.20E-03 4.60E-02 ENSG00000073670 ADAM11 -3.22 -3.37 5.20E-03 4.60E-02 ENSG00000148123 . -5.19 -3.37 5.20E-03 4.60E-02 ENSG00000161551 ZNF577 -2.13 -3.37 5.20E-03 4.60E-02 ENSG00000157542 KCNJ6 -3.06 -3.37 5.20E-03 4.60E-02 ENSG00000089123 TASP1 2.02 3.37 5.20E-03 4.60E-02 ENSG00000171016 PYGO1 -1.05 -3.37 5.20E-03 4.60E-02 ENSG00000175893 ZDHHC21 -1.44 -3.37 5.20E-03 4.60E-02 ENSG00000139144 PIK3C2G 5.9 3.37 5.20E-03 4.60E-02 ENSG00000088538 DOCK3 -1.83 -3.37 5.20E-03 4.60E-02 ENSG00000079459 FDFT1 1.62 3.37 5.20E-03 4.60E-02 ENSG00000167654 ATCAY -3.11 -3.37 5.20E-03 4.60E-02 ENSG00000090661 CERS4 -1.58 -3.37 5.20E-03 4.60E-02 ENSG00000180357 ZNF609 -1.65 -3.37 5.20E-03 4.60E-02 ENSG00000100376 FAM118A 2.3 3.36 5.30E-03 4.60E-02 ENSG00000128591 FLNC 2.96 3.36 5.30E-03 4.60E-02 ENSG00000189171 S100A13 3.12 3.36 5.30E-03 4.70E-02 ENSG00000101745 ANKRD12 -1.21 -3.36 5.30E-03 4.70E-02 ENSG00000117713 ARID1A -2.64 -3.36 5.30E-03 4.70E-02 ENSG00000164164 OTUD4 -1.26 -3.36 5.30E-03 4.70E-02 ENSG00000218510 LINC00339 2.22 3.36 5.30E-03 4.70E-02 ENSG00000116132 PRRX1 8.25 3.36 5.30E-03 4.70E-02 ENSG00000078053 AMPH -2.61 -3.35 5.40E-03 4.70E-02 ENSG00000198216 CACNA1E -3.59 -3.35 5.40E-03 4.70E-02 ENSG00000103160 HSDL1 -2.25 -3.35 5.40E-03 4.70E-02 ENSG00000163808 KIF15 2.87 3.35 5.40E-03 4.70E-02 ENSG00000185088 RPS27L 1.58 3.35 5.40E-03 4.70E-02 ENSG00000085063 CD59 2.29 3.35 5.40E-03 4.70E-02 ENSG00000165891 E2F7 2.86 3.35 5.40E-03 4.70E-02 ENSG00000112039 FANCE -2.3 -3.35 5.40E-03 4.70E-02 ENSG00000180596 HIST1H2BC 2.04 3.35 5.40E-03 4.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000082684 SEMA5B -2.91 -3.35 5.40E-03 4.70E-02 ENSG00000115963 2.34 3.35 5.40E-03 4.70E-02 ENSG00000105877 DNAH11 -7.22 -3.35 5.40E-03 4.70E-02 ENSG00000068001 HYAL2 1.54 3.34 5.50E-03 4.70E-02 ENSG00000096872 IFT74 1.89 3.34 5.50E-03 4.70E-02 ENSG00000184307 ZDHHC23 -3.39 -3.34 5.50E-03 4.80E-02 ENSG00000166292 TMEM100 4.86 3.34 5.50E-03 4.80E-02 ENSG00000165072 MAMDC2 6.73 3.34 5.50E-03 4.80E-02 ENSG00000101911 PRPS2 -4.34 -3.34 5.50E-03 4.80E-02 ENSG00000164398 ACSL6 -1.67 -3.34 5.50E-03 4.80E-02 ENSG00000178177 LCORL -1.5 -3.34 5.50E-03 4.80E-02 ENSG00000139168 ZCRB1 1.31 3.34 5.50E-03 4.80E-02 ENSG00000117600 . -2.56 -3.34 5.50E-03 4.80E-02 ENSG00000146216 TTBK1 -2.5 -3.34 5.50E-03 4.80E-02 ENSG00000138135 CH25H 6.5 3.34 5.50E-03 4.80E-02 ENSG00000100473 COCH -3.36 -3.34 5.50E-03 4.80E-02 ENSG00000135828 RNASEL 4.05 3.34 5.50E-03 4.80E-02 ENSG00000158402 CDC25C 3.52 3.34 5.50E-03 4.80E-02 ENSG00000231720 . 3.33 3.34 5.50E-03 4.80E-02 ENSG00000263244 . 1.33 3.34 5.60E-03 4.80E-02 ENSG00000126787 DLGAP5 2.6 3.33 5.60E-03 4.80E-02 ENSG00000187955 COL14A1 7.55 3.33 5.60E-03 4.80E-02 ENSG00000077684 PHF17 -2.64 -3.33 5.60E-03 4.80E-02 ENSG00000254510 . -4.67 -3.33 5.60E-03 4.80E-02 ENSG00000132109 TRIM21 2.17 3.33 5.60E-03 4.80E-02 ENSG00000139044 B4GALNT3 -3.11 -3.33 5.60E-03 4.80E-02 ENSG00000155052 CNTNAP5 -7.01 -3.33 5.60E-03 4.80E-02 ENSG00000066185 ZMYND12 4.7 3.33 5.60E-03 4.80E-02 ENSG00000034053 APBA2 -2.38 -3.33 5.60E-03 4.80E-02 ENSG00000120675 DNAJC15 2.75 3.33 5.60E-03 4.80E-02 ENSG00000243716 . -2.36 -3.32 5.70E-03 4.90E-02 ENSG00000141441 FAM59A 1.59 3.32 5.70E-03 4.90E-02 ENSG00000185130 HIST1H2BL 2.95 3.32 5.70E-03 4.90E-02 ENSG00000135476 ESPL1 2.47 3.32 5.70E-03 4.90E-02 ENSG00000138653 NDST4 -3.91 -3.32 5.70E-03 4.90E-02 ENSG00000033627 ATP6V0A1 -1.45 -3.32 5.70E-03 4.90E-02 ENSG00000091157 WDR7 -1.14 -3.32 5.70E-03 4.90E-02 ENSG00000082805 ERC1 -1.51 -3.32 5.70E-03 4.90E-02 ENSG00000125247 TMTC4 -1.24 -3.32 5.70E-03 4.90E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000148444 COMMD3 1.62 3.32 5.70E-03 4.90E-02 ENSG00000074054 CLASP1 -1.02 -3.32 5.70E-03 4.90E-02 ENSG00000181751 C5orf30 -2.15 -3.32 5.80E-03 4.90E-02 ENSG00000132196 HSD17B7 2.39 3.32 5.80E-03 4.90E-02 ENSG00000134107 BHLHE40 2.37 3.32 5.80E-03 4.90E-02 ENSG00000188295 ZNF669 -1.61 -3.32 5.80E-03 4.90E-02 ENSG00000188522 FAM83G 3.01 3.32 5.80E-03 4.90E-02 ENSG00000101191 DIDO1 -0.98 -3.32 5.80E-03 4.90E-02 ENSG00000188338 SLC38A3 2.47 3.32 5.80E-03 4.90E-02 ENSG00000130962 PRRG1 1.98 3.31 5.80E-03 4.90E-02 ENSG00000174600 CMKLR1 9.14 3.31 5.80E-03 4.90E-02 ENSG00000152332 UHMK1 1.32 3.31 5.80E-03 4.90E-02 ENSG00000173548 SNX33 1.51 3.31 5.80E-03 4.90E-02 ENSG00000142731 PLK4 2.69 3.31 5.80E-03 4.90E-02 ENSG00000107020 PLGRKT 2.32 3.31 5.80E-03 4.90E-02 ENSG00000242808 -OT -4.52 -3.31 5.80E-03 4.90E-02 ENSG00000143674 . -2.35 -3.31 5.80E-03 4.90E-02 ENSG00000240583 AQP1 -2.54 -3.31 5.80E-03 4.90E-02 ENSG00000198106 SNX29P2 -2.55 -3.31 5.80E-03 4.90E-02 ENSG00000099204 ABLIM1 -2.79 -3.31 5.90E-03 4.90E-02 ENSG00000147224 PRPS1 -1.22 -3.31 5.90E-03 4.90E-02 ENSG00000104044 OCA2 3.61 3.31 5.90E-03 4.90E-02 ENSG00000130224 LRCH2 -2 -3.3 5.90E-03 4.90E-02 ENSG00000109790 KLHL5 -1.2 -3.3 5.90E-03 4.90E-02 ENSG00000165996 PTPLA -3.44 -3.3 5.90E-03 4.90E-02 ENSG00000129235 TXNDC17 1.23 3.3 5.90E-03 4.90E-02 ENSG00000169918 OTUD7A -3.53 -3.3 5.90E-03 4.90E-02 ENSG00000137812 CASC5 2.68 3.3 5.90E-03 4.90E-02 ENSG00000112249 ASCC3 1.27 3.3 5.90E-03 4.90E-02 ENSG00000178662 CSRNP3 -1.96 -3.3 5.90E-03 5.00E-02 ENSG00000178974 FBXO34 -1.14 -3.3 5.90E-03 5.00E-02 ENSG00000020181 GPR124 6.06 3.3 5.90E-03 5.00E-02 ENSG00000152527 PLEKHH2 4.2 3.3 6.00E-03 5.00E-02 ENSG00000115947 ORC4 -1.21 -3.3 6.00E-03 5.00E-02 ENSG00000081913 PHLPP1 -2.18 -3.3 6.00E-03 5.00E-02 ENSG00000104427 ZC2HC1A -2.16 -3.3 6.00E-03 5.00E-02 Ensembl ID, gene symbol, log2 fold change, t statistic, P value and FDR.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 4. Differentially expressed genes for PCID (untreated or treated with

potassium chloride) at FDR 5%

Ensembl Gene symbol logFC t P FDR ENSG00000068028 RASSF1 2.28 12.95 1.10E-08 6.60E-05 ENSG00000070495 JMJD6 2.39 12.77 1.30E-08 6.60E-05 ENSG00000134294 SLC38A2 4.15 12.71 1.40E-08 6.60E-05 ENSG00000165355 FBXO33 2.11 11.29 5.70E-08 2.00E-04 ENSG00000100811 YY1 1.39 11.07 7.10E-08 2.00E-04 ENSG00000132475 H3F3B -1.66 -10.52 1.30E-07 2.70E-04 ENSG00000196678 ERI2 -3.22 -10.26 1.70E-07 2.70E-04 ENSG00000188215 DCUN1D3 1.79 10.2 1.80E-07 2.70E-04 ENSG00000132680 KIAA0907 2.2 10.14 2.00E-07 2.70E-04 ENSG00000185875 THNSL1 -2.7 -10.06 2.10E-07 2.70E-04 ENSG00000115875 SRSF7 -1.98 -10.05 2.10E-07 2.70E-04 ENSG00000186298 PPP1CC 1.51 9.97 2.30E-07 2.70E-04 ENSG00000198642 KLHL9 -1.88 -9.9 2.60E-07 2.70E-04 ENSG00000181450 ZNF678 -2.23 -9.72 3.10E-07 3.10E-04 ENSG00000197128 ZNF772 -1.82 -9.67 3.30E-07 3.10E-04 ENSG00000116954 RRAGC 1.77 9.59 3.70E-07 3.20E-04 ENSG00000126814 TRMT5 -1.5 -9.34 4.90E-07 3.90E-04 ENSG00000244026 FAM86DP -2.93 -9.28 5.30E-07 3.90E-04 ENSG00000170836 PPM1D 2.15 9.25 5.50E-07 3.90E-04 ENSG00000196821 C6orf106 1.54 9.22 5.70E-07 3.90E-04 ENSG00000196793 ZNF239 -2.48 -9.17 6.00E-07 4.00E-04 ENSG00000182986 ZNF320 -1.53 -9.03 7.20E-07 4.30E-04 ENSG00000263244 . -1.83 -9 7.40E-07 4.30E-04 ENSG00000141040 ZNF287 -2.21 -8.99 7.50E-07 4.30E-04 ENSG00000166478 ZNF143 1.88 8.88 8.60E-07 4.70E-04 ENSG00000141098 GFOD2 2.23 8.86 8.90E-07 4.70E-04 ENSG00000215251 FASTKD5 1.64 8.68 1.10E-06 5.70E-04 ENSG00000137413 TAF8 1.69 8.58 1.20E-06 6.20E-04 ENSG00000180938 ZNF572 -4.13 -8.49 1.40E-06 6.30E-04 ENSG00000123268 ATF1 1.69 8.47 1.40E-06 6.30E-04 ENSG00000269343 ZNF587B -2.14 -8.46 1.50E-06 6.30E-04 ENSG00000214654 . -3.16 -8.42 1.50E-06 6.30E-04 ENSG00000183808 RBM12B -1.77 -8.41 1.50E-06 6.30E-04 ENSG00000235109 ZNF323 -1.94 -8.4 1.60E-06 6.30E-04

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000128000 ZNF780B -1.79 -8.35 1.70E-06 6.30E-04 ENSG00000131127 ZNF141 -2.02 -8.35 1.70E-06 6.30E-04 ENSG00000178974 FBXO34 1.47 8.35 1.70E-06 6.30E-04 ENSG00000183340 JRKL -1.92 -8.23 2.00E-06 7.10E-04 ENSG00000110721 CHKA 1.7 8.21 2.00E-06 7.10E-04 ENSG00000223573 PLAC2 4.82 8.2 2.00E-06 7.10E-04 ENSG00000120709 FAM53C 1.72 8.16 2.20E-06 7.40E-04 ENSG00000009790 TRAF3IP3 -3.8 -8.1 2.30E-06 7.70E-04 ENSG00000119787 ATL2 1.44 8.02 2.60E-06 8.20E-04 ENSG00000090612 ZNF268 -1.63 -7.99 2.70E-06 8.20E-04 ENSG00000182831 C16orf72 1.32 7.99 2.70E-06 8.20E-04 ENSG00000123136 DDX39A 1.65 7.98 2.80E-06 8.20E-04 ENSG00000102554 KLF5 3.51 7.96 2.80E-06 8.20E-04 ENSG00000175283 DOLK -1.56 -7.95 2.80E-06 8.20E-04 ENSG00000168661 ZNF30 -2.2 -7.92 3.00E-06 8.40E-04 ENSG00000162396 PARS2 -2.84 -7.88 3.10E-06 8.50E-04 ENSG00000170949 ZNF160 -1.62 -7.88 3.10E-06 8.50E-04 ENSG00000177853 ZNF518A -1.3 -7.83 3.40E-06 8.90E-04 ENSG00000153914 SREK1 1.32 7.82 3.40E-06 8.90E-04 ENSG00000187742 SECISBP2 -1.13 -7.81 3.50E-06 8.90E-04 ENSG00000197044 ZNF441 -2.64 -7.76 3.70E-06 9.20E-04 ENSG00000049769 PPP1R3F 1.45 7.69 4.10E-06 9.20E-04 ENSG00000181035 SLC25A42 1.99 7.69 4.10E-06 9.20E-04 ENSG00000144120 TMEM177 -2.81 -7.69 4.10E-06 9.20E-04 ENSG00000145723 GIN1 -1.85 -7.69 4.10E-06 9.20E-04 ENSG00000203326 ZNF525 -1.86 -7.67 4.20E-06 9.20E-04 ENSG00000144792 ZNF660 -1.9 -7.67 4.20E-06 9.20E-04 ENSG00000162757 C1orf74 -3.29 -7.67 4.20E-06 9.20E-04 ENSG00000155868 MED7 -1.57 -7.67 4.20E-06 9.20E-04 ENSG00000141646 SMAD4 1.08 7.66 4.20E-06 9.20E-04 ENSG00000019995 ZRANB1 1.39 7.65 4.30E-06 9.20E-04 ENSG00000178567 EPM2AIP1 -1.27 -7.63 4.40E-06 9.20E-04 ENSG00000014123 UFL1 -1.2 -7.62 4.50E-06 9.20E-04 ENSG00000253190 . -2.47 -7.61 4.50E-06 9.20E-04 ENSG00000109920 FNBP4 1.45 7.58 4.70E-06 9.40E-04 ENSG00000136100 VPS36 -1.26 -7.58 4.70E-06 9.40E-04 ENSG00000153575 TUBGCP5 -1.38 -7.52 5.10E-06 9.90E-04 ENSG00000105793 GTPBP10 -1.46 -7.52 5.10E-06 9.90E-04 ENSG00000005700 IBTK -1.45 -7.5 5.30E-06 1.00E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000157578 LCA5L -3.34 -7.5 5.30E-06 1.00E-03 ENSG00000185838 GNB1L 3.03 7.48 5.40E-06 1.00E-03 ENSG00000197976 AKAP17A 1.61 7.45 5.70E-06 1.00E-03 ENSG00000108264 TADA2A -1.85 -7.39 6.20E-06 1.10E-03 ENSG00000099622 CIRBP -1.72 -7.38 6.30E-06 1.10E-03 ENSG00000196670 ZFP62 -1.71 -7.37 6.30E-06 1.10E-03 ENSG00000243927 MRPS6 1.87 7.35 6.50E-06 1.10E-03 ENSG00000139697 SBNO1 0.99 7.34 6.60E-06 1.10E-03 ENSG00000174206 C12orf66 -2.03 -7.33 6.70E-06 1.10E-03 ENSG00000175470 PPP2R2D 1.13 7.33 6.80E-06 1.10E-03 ENSG00000180198 RCC1 1.47 7.18 8.40E-06 1.40E-03 ENSG00000174136 RGMB 1.41 7.16 8.60E-06 1.40E-03 ENSG00000170385 SLC30A1 -1.7 -7.15 8.70E-06 1.40E-03 ENSG00000134077 THUMPD3 -1.2 -7.14 8.80E-06 1.40E-03 ENSG00000054267 ARID4B 1.12 7.13 8.90E-06 1.40E-03 ENSG00000123352 SPATS2 1.91 7.12 9.00E-06 1.40E-03 ENSG00000196345 ZNF167 -2.8 -7.12 9.10E-06 1.40E-03 ENSG00000198743 SLC5A3 1.78 7.09 9.50E-06 1.50E-03 ENSG00000110172 CHORDC1 1.31 7.07 9.70E-06 1.50E-03 ENSG00000155438 MKI67IP -1.59 -7.07 9.70E-06 1.50E-03 ENSG00000137040 RANBP6 -1.27 -7.05 1.00E-05 1.50E-03 ENSG00000186812 ZNF397 -1.22 -7.04 1.00E-05 1.50E-03 ENSG00000196981 WDR5B -1.83 -7.02 1.00E-05 1.50E-03 ENSG00000170325 PRDM10 1.84 6.98 1.10E-05 1.60E-03 ENSG00000121440 PDZRN3 1.38 6.97 1.10E-05 1.60E-03 ENSG00000186496 ZNF396 -2.47 -6.97 1.10E-05 1.60E-03 ENSG00000022976 ZNF839 -1.39 -6.97 1.10E-05 1.60E-03 ENSG00000088451 TGDS -2.5 -6.96 1.20E-05 1.60E-03 ENSG00000154059 IMPACT -1.07 -6.95 1.20E-05 1.60E-03 ENSG00000157184 CPT2 -1.71 -6.95 1.20E-05 1.60E-03 ENSG00000122783 C7orf49 -1.21 -6.94 1.20E-05 1.60E-03 ENSG00000141642 ELAC1 -2.21 -6.94 1.20E-05 1.60E-03 ENSG00000158483 FAM86C1 -3.46 -6.9 1.20E-05 1.60E-03 ENSG00000156232 WHAMM 1.54 6.87 1.30E-05 1.70E-03 ENSG00000244462 RBM12 -1.27 -6.86 1.30E-05 1.70E-03 ENSG00000181264 TMEM136 -1.55 -6.84 1.40E-05 1.70E-03 ENSG00000121903 ZSCAN20 -1.51 -6.83 1.40E-05 1.70E-03 ENSG00000110075 PPP6R3 0.96 6.81 1.40E-05 1.80E-03 ENSG00000138311 ZNF365 -1.83 -6.79 1.50E-05 1.80E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000262944 . -1.76 -6.79 1.50E-05 1.80E-03 ENSG00000055147 FAM114A2 -1.33 -6.76 1.50E-05 1.90E-03 ENSG00000251669 FAM86EP -3.38 -6.75 1.60E-05 1.90E-03 ENSG00000148835 TAF5 2.02 6.73 1.60E-05 1.90E-03 ENSG00000164603 C7orf60 1.55 6.72 1.60E-05 1.90E-03 ENSG00000186446 ZNF501 -2.63 -6.72 1.60E-05 1.90E-03 ENSG00000165006 UBAP1 1.33 6.71 1.70E-05 1.90E-03 ENSG00000174233 ADCY6 1.23 6.7 1.70E-05 1.90E-03 ENSG00000144283 PKP4 1.22 6.7 1.70E-05 1.90E-03 ENSG00000134256 CD101 4.05 6.69 1.70E-05 2.00E-03 ENSG00000180257 ZNF816 -1.95 -6.68 1.70E-05 2.00E-03 ENSG00000136891 TEX10 1.01 6.66 1.80E-05 2.00E-03 ENSG00000132388 UBE2G1 0.99 6.66 1.80E-05 2.00E-03 ENSG00000154803 FLCN 1.35 6.64 1.80E-05 2.00E-03 ENSG00000117222 RBBP5 1 6.64 1.90E-05 2.00E-03 ENSG00000171469 ZNF561 -1.23 -6.63 1.90E-05 2.00E-03 ENSG00000196409 ZNF658 -2.16 -6.63 1.90E-05 2.00E-03 ENSG00000011114 BTBD7 0.83 6.62 1.90E-05 2.00E-03 ENSG00000106003 LFNG -2.99 -6.6 2.00E-05 2.10E-03 ENSG00000118900 UBN1 1.39 6.59 2.00E-05 2.10E-03 ENSG00000198890 PRMT6 -2.26 -6.58 2.00E-05 2.10E-03 ENSG00000198964 SGMS1 1.3 6.56 2.10E-05 2.10E-03 ENSG00000205808 PPAPDC2 -2.11 -6.54 2.10E-05 2.20E-03 ENSG00000198517 MAFK 2.75 6.54 2.20E-05 2.20E-03 ENSG00000114796 KLHL24 1.54 6.53 2.20E-05 2.20E-03 ENSG00000204177 BMS1P1 -2.13 -6.52 2.20E-05 2.20E-03 ENSG00000011243 AKAP8L 1.58 6.52 2.20E-05 2.20E-03 ENSG00000171604 CXXC5 -1.5 -6.51 2.20E-05 2.20E-03 ENSG00000109618 SEPSECS -1.48 -6.51 2.30E-05 2.20E-03 ENSG00000174599 TRAM1L1 -2.15 -6.49 2.30E-05 2.30E-03 ENSG00000243701 . -1.35 -6.48 2.30E-05 2.30E-03 ENSG00000144655 CSRNP1 2.09 6.47 2.40E-05 2.30E-03 ENSG00000132003 ZSWIM4 2.26 6.47 2.40E-05 2.30E-03 ENSG00000160172 FAM86C2P -3.44 -6.46 2.40E-05 2.30E-03 ENSG00000169515 CCDC8 -1.83 -6.46 2.40E-05 2.30E-03 ENSG00000183161 FANCF -1.48 -6.45 2.50E-05 2.30E-03 ENSG00000123975 CKS2 1.91 6.44 2.50E-05 2.30E-03 ENSG00000189050 RNFT1 -1.96 -6.41 2.60E-05 2.40E-03 ENSG00000147789 ZNF7 -1.24 -6.38 2.70E-05 2.50E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000160961 ZNF333 -1.21 -6.38 2.70E-05 2.50E-03 ENSG00000164051 CCDC51 -1.61 -6.38 2.80E-05 2.50E-03 ENSG00000202515 VTRNA1-3 -2.13 -6.32 3.00E-05 2.70E-03 ENSG00000156860 FBRS 1.45 6.31 3.00E-05 2.70E-03 ENSG00000135541 AHI1 0.86 6.3 3.10E-05 2.70E-03 ENSG00000185567 AHNAK2 -2.07 -6.3 3.10E-05 2.70E-03 ENSG00000068745 IP6K2 1.33 6.28 3.20E-05 2.80E-03 ENSG00000177613 CSTF2T -1.06 -6.28 3.20E-05 2.80E-03 ENSG00000127993 RBM48 1.23 6.28 3.20E-05 2.80E-03 ENSG00000121350 PYROXD1 -2.11 -6.26 3.30E-05 2.80E-03 ENSG00000178700 DHFRL1 -1.54 -6.26 3.30E-05 2.80E-03 ENSG00000082213 C5orf22 -1.3 -6.26 3.30E-05 2.80E-03 ENSG00000151461 UPF2 1.14 6.25 3.30E-05 2.80E-03 ENSG00000184517 ZFP1 -1.23 -6.25 3.40E-05 2.80E-03 ENSG00000198346 ZNF813 -1.34 -6.24 3.40E-05 2.80E-03 ENSG00000198855 FICD -1.86 -6.23 3.50E-05 2.90E-03 ENSG00000150347 ARID5B 2.63 6.23 3.50E-05 2.90E-03 ENSG00000139163 ETNK1 1.41 6.22 3.50E-05 2.90E-03 ENSG00000198298 ZNF485 -2.33 -6.21 3.60E-05 2.90E-03 ENSG00000065183 WDR3 -1.02 -6.2 3.60E-05 3.00E-03 ENSG00000254004 ZNF260 -1.04 -6.19 3.70E-05 3.00E-03 ENSG00000089335 ZNF302 -1.22 -6.16 3.90E-05 3.10E-03 ENSG00000179941 BBS10 -1.53 -6.15 3.90E-05 3.10E-03 ENSG00000127980 PEX1 -1 -6.15 3.90E-05 3.10E-03 ENSG00000188725 C5orf43 -1.11 -6.14 4.00E-05 3.10E-03 ENSG00000153561 RMND5A 1.02 6.14 4.00E-05 3.10E-03 ENSG00000137124 ALDH1B1 -1.72 -6.14 4.00E-05 3.10E-03 ENSG00000117289 TXNIP -2.46 -6.13 4.00E-05 3.10E-03 ENSG00000183624 C3orf37 1.23 6.12 4.10E-05 3.20E-03 ENSG00000166233 ARIH1 0.78 6.12 4.10E-05 3.20E-03 ENSG00000106829 TLE4 1.43 6.1 4.30E-05 3.30E-03 ENSG00000249459 ZNF286B 2.28 6.08 4.40E-05 3.30E-03 ENSG00000174796 THAP6 -1.41 -6.07 4.40E-05 3.30E-03 ENSG00000166532 RIMKLB -1.51 -6.07 4.40E-05 3.30E-03 ENSG00000196323 ZBTB44 1.04 6.07 4.50E-05 3.40E-03 ENSG00000167522 ANKRD11 1.92 6.06 4.50E-05 3.40E-03 ENSG00000135679 -1.13 -6.05 4.60E-05 3.40E-03 ENSG00000172175 MALT1 1.39 6.04 4.70E-05 3.40E-03 ENSG00000152219 ARL14EP -1.15 -6.03 4.70E-05 3.40E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000013441 CLK1 1.21 6.03 4.80E-05 3.40E-03 ENSG00000170681 MURC 2.47 6.02 4.80E-05 3.40E-03 ENSG00000257315 ZBED6 1.69 6.02 4.80E-05 3.40E-03 ENSG00000087206 UIMC1 1.21 6.02 4.80E-05 3.40E-03 ENSG00000100591 AHSA1 0.83 6.02 4.80E-05 3.40E-03 ENSG00000068097 HEATR6 -1.15 -6.02 4.90E-05 3.40E-03 ENSG00000008405 CRY1 1.18 6.01 4.90E-05 3.50E-03 ENSG00000180964 TCEAL8 -1.36 -6 5.00E-05 3.50E-03 ENSG00000146433 TMEM181 -1.13 -5.96 5.30E-05 3.70E-03 ENSG00000185262 FAM100B 3.05 5.96 5.30E-05 3.70E-03 ENSG00000123415 SMUG1 -1.12 -5.96 5.30E-05 3.70E-03 ENSG00000267350 . 1.46 5.96 5.30E-05 3.70E-03 ENSG00000143811 PYCR2 -1.26 -5.95 5.40E-05 3.70E-03 ENSG00000106261 ZKSCAN1 -1.03 -5.94 5.50E-05 3.70E-03 ENSG00000187187 ZNF546 -1.48 -5.94 5.50E-05 3.70E-03 ENSG00000198185 ZNF334 -1.5 -5.94 5.50E-05 3.70E-03 ENSG00000253738 . -1.27 -5.93 5.50E-05 3.70E-03 ENSG00000102409 BEX4 -0.73 -5.92 5.70E-05 3.80E-03 ENSG00000141458 NPC1 1.35 5.91 5.70E-05 3.80E-03 ENSG00000167566 NCKAP5L 2.1 5.91 5.70E-05 3.80E-03 ENSG00000173275 ZNF449 -1.43 -5.9 5.80E-05 3.80E-03 ENSG00000143315 PIGM -1.63 -5.9 5.80E-05 3.80E-03 ENSG00000198924 DCLRE1A -1.53 -5.9 5.80E-05 3.80E-03 ENSG00000114993 RTKN -1.78 -5.89 6.00E-05 3.90E-03 ENSG00000162927 PUS10 -2.36 -5.88 6.00E-05 3.90E-03 ENSG00000160633 SAFB 1.29 5.87 6.20E-05 4.00E-03 ENSG00000221843 C2orf16 -2.21 -5.86 6.20E-05 4.00E-03 ENSG00000140543 DET1 -1.69 -5.84 6.50E-05 4.10E-03 ENSG00000162775 RBM15 0.87 5.84 6.50E-05 4.10E-03 ENSG00000148300 REXO4 1.29 5.84 6.50E-05 4.10E-03 ENSG00000197937 ZNF347 -1.18 -5.84 6.50E-05 4.10E-03 ENSG00000171456 ASXL1 0.98 5.83 6.50E-05 4.10E-03 ENSG00000183864 TOB2 1.63 5.83 6.60E-05 4.10E-03 ENSG00000100865 CINP -1.14 -5.82 6.60E-05 4.10E-03 ENSG00000162139 NEU3 -1.26 -5.82 6.60E-05 4.10E-03 ENSG00000065559 MAP2K4 1.44 5.81 6.80E-05 4.20E-03 ENSG00000101935 AMMECR1 1.24 5.8 6.90E-05 4.20E-03 ENSG00000102967 DHODH -1.93 -5.78 7.10E-05 4.30E-03 ENSG00000135953 MFSD9 1.42 5.77 7.20E-05 4.40E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000108666 C17orf75 -1.37 -5.76 7.40E-05 4.50E-03 ENSG00000036257 CUL3 0.98 5.74 7.60E-05 4.60E-03 ENSG00000148843 PDCD11 -0.8 -5.72 7.80E-05 4.60E-03 ENSG00000069849 ATP1B3 1.41 5.72 7.80E-05 4.60E-03 ENSG00000198482 ZNF808 -1.13 -5.72 7.80E-05 4.60E-03 ENSG00000011405 PIK3C2A 0.82 5.72 7.80E-05 4.60E-03 ENSG00000151458 ANKRD50 1.42 5.72 7.90E-05 4.60E-03 ENSG00000032444 PNPLA6 1.73 5.71 8.00E-05 4.60E-03 ENSG00000140153 WDR20 0.91 5.71 8.00E-05 4.60E-03 ENSG00000131389 SLC6A6 2.12 5.71 8.00E-05 4.60E-03 ENSG00000134186 PRPF38B 1.32 5.7 8.10E-05 4.70E-03 ENSG00000138621 PPCDC -2.11 -5.7 8.10E-05 4.70E-03 ENSG00000097096 SYDE2 1.23 5.69 8.20E-05 4.70E-03 ENSG00000196653 ZNF502 -2.49 -5.68 8.40E-05 4.80E-03 ENSG00000143514 TP53BP2 0.9 5.68 8.40E-05 4.80E-03 ENSG00000198521 ZNF43 -1.5 -5.67 8.60E-05 4.90E-03 ENSG00000108733 PEX12 -1.84 -5.66 8.60E-05 4.90E-03 ENSG00000011566 MAP4K3 0.93 5.66 8.70E-05 4.90E-03 ENSG00000198301 SDAD1 -1.26 -5.65 8.70E-05 4.90E-03 ENSG00000118246 FASTKD2 -1.09 -5.65 8.80E-05 4.90E-03 ENSG00000179632 MAF1 1.02 5.65 8.80E-05 4.90E-03 ENSG00000184271 POU6F1 1.34 5.64 8.90E-05 4.90E-03 ENSG00000143367 TUFT1 1.83 5.63 9.20E-05 5.00E-03 ENSG00000005889 ZFX 0.75 5.61 9.30E-05 5.10E-03 ENSG00000135763 URB2 -1.12 -5.61 9.40E-05 5.20E-03 ENSG00000060339 CCAR1 0.92 5.6 9.50E-05 5.20E-03 ENSG00000128607 KLHDC10 0.9 5.6 9.50E-05 5.20E-03 ENSG00000158615 PPP1R15B 1.36 5.6 9.60E-05 5.20E-03 ENSG00000164291 ARSK 1.67 5.59 9.60E-05 5.20E-03 ENSG00000159905 ZNF221 -1.41 -5.59 9.70E-05 5.20E-03 ENSG00000172375 C2CD2L 1.67 5.59 9.70E-05 5.20E-03 ENSG00000102908 NFAT5 1.25 5.58 9.90E-05 5.20E-03 ENSG00000105171 POP4 -1.24 -5.58 9.90E-05 5.20E-03 ENSG00000197557 TTC30A -2.2 -5.57 1.00E-04 5.30E-03 ENSG00000117597 DIEXF -1.2 -5.57 1.00E-04 5.30E-03 ENSG00000125875 TBC1D20 0.99 5.56 1.00E-04 5.30E-03 ENSG00000164967 RPP25L -1.63 -5.56 1.00E-04 5.30E-03 ENSG00000121879 PIK3CA 0.92 5.56 1.00E-04 5.30E-03 ENSG00000090989 EXOC1 -0.82 -5.56 1.00E-04 5.30E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000197841 ZNF181 -1.22 -5.55 1.00E-04 5.30E-03 ENSG00000107669 ATE1 0.74 5.55 1.00E-04 5.30E-03 ENSG00000104960 PTOV1 1.18 5.54 1.10E-04 5.40E-03 ENSG00000119927 GPAM -0.91 -5.53 1.10E-04 5.40E-03 ENSG00000135845 PIGC -1.01 -5.51 1.10E-04 5.60E-03 ENSG00000006831 ADIPOR2 0.9 5.51 1.10E-04 5.60E-03 ENSG00000010244 ZNF207 0.66 5.51 1.10E-04 5.60E-03 ENSG00000156026 MCU 1.45 5.51 1.10E-04 5.60E-03 ENSG00000164941 INTS8 1.3 5.5 1.10E-04 5.60E-03 ENSG00000116337 AMPD2 1.05 5.5 1.10E-04 5.60E-03 ENSG00000196214 ZNF766 -1.62 -5.5 1.10E-04 5.60E-03 ENSG00000258708 . -3.66 -5.49 1.10E-04 5.70E-03 ENSG00000169288 MRPL1 -1.81 -5.49 1.10E-04 5.70E-03 ENSG00000111358 GTF2H3 -1.1 -5.49 1.10E-04 5.70E-03 ENSG00000127125 PPCS -1.11 -5.48 1.20E-04 5.70E-03 ENSG00000255561 FDXACB1 -2.34 -5.48 1.20E-04 5.70E-03 ENSG00000257242 . 2.63 5.46 1.20E-04 5.90E-03 ENSG00000236255 . 2.27 5.45 1.20E-04 5.90E-03 ENSG00000105856 HBP1 1.38 5.45 1.20E-04 5.90E-03 ENSG00000112739 PRPF4B 0.87 5.44 1.20E-04 6.00E-03 ENSG00000153767 GTF2E1 -1.27 -5.43 1.30E-04 6.00E-03 ENSG00000164327 RICTOR 0.93 5.43 1.30E-04 6.10E-03 ENSG00000173894 CBX2 -1.65 -5.43 1.30E-04 6.10E-03 ENSG00000107223 EDF1 -0.88 -5.42 1.30E-04 6.10E-03 ENSG00000113555 PCDH12 2.69 5.42 1.30E-04 6.10E-03 ENSG00000140367 UBE2Q2 -1.06 -5.39 1.40E-04 6.40E-03 ENSG00000167264 DUS2L -1.26 -5.39 1.40E-04 6.40E-03 ENSG00000172273 HINFP 1.45 5.38 1.40E-04 6.40E-03 ENSG00000063127 SLC6A16 2.13 5.38 1.40E-04 6.40E-03 ENSG00000170854 MINA -1.19 -5.38 1.40E-04 6.50E-03 ENSG00000145675 PIK3R1 -1.37 -5.37 1.40E-04 6.50E-03 ENSG00000158301 GPRASP2 -1.61 -5.37 1.40E-04 6.50E-03 ENSG00000144559 TAMM41 -1.61 -5.37 1.40E-04 6.50E-03 ENSG00000101901 ALG13 -0.92 -5.36 1.40E-04 6.60E-03 ENSG00000103381 CPPED1 -1.49 -5.36 1.40E-04 6.60E-03 ENSG00000157212 PAXIP1 1.17 5.35 1.40E-04 6.60E-03 ENSG00000105429 MEGF8 1.18 5.34 1.50E-04 6.70E-03 ENSG00000165416 SUGT1 0.75 5.34 1.50E-04 6.70E-03 ENSG00000167562 ZNF701 -1.16 -5.33 1.50E-04 6.70E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000165185 KIAA1958 1.59 5.33 1.50E-04 6.80E-03 ENSG00000198860 TSEN15 -1.14 -5.33 1.50E-04 6.80E-03 ENSG00000204673 AKT1S1 1.52 5.33 1.50E-04 6.80E-03 ENSG00000125846 ZNF133 -1.17 -5.32 1.50E-04 6.80E-03 ENSG00000196378 ZNF34 -1.38 -5.32 1.50E-04 6.80E-03 ENSG00000149182 ARFGAP2 -1.05 -5.32 1.50E-04 6.80E-03 ENSG00000166398 KIAA0355 0.99 5.31 1.50E-04 6.80E-03 ENSG00000110851 PRDM4 0.72 5.31 1.50E-04 6.80E-03 ENSG00000170832 USP32 0.95 5.31 1.50E-04 6.80E-03 ENSG00000155097 ATP6V1C1 0.73 5.31 1.50E-04 6.80E-03 ENSG00000104320 NBN -1.36 -5.31 1.50E-04 6.80E-03 ENSG00000018510 AGPS -0.69 -5.31 1.50E-04 6.80E-03 ENSG00000128285 MCHR1 -2.42 -5.31 1.60E-04 6.80E-03 ENSG00000239900 ADSL -0.81 -5.3 1.60E-04 6.80E-03 ENSG00000011523 CEP68 -1.04 -5.3 1.60E-04 6.80E-03 ENSG00000171503 ETFDH 1.13 5.3 1.60E-04 6.80E-03 ENSG00000114126 TFDP2 0.82 5.29 1.60E-04 6.80E-03 ENSG00000111707 SUDS3 0.88 5.29 1.60E-04 6.80E-03 ENSG00000180626 ZNF594 -1.52 -5.29 1.60E-04 6.80E-03 ENSG00000049883 PTCD2 -1.7 -5.29 1.60E-04 6.80E-03 ENSG00000155100 OTUD6B -1.2 -5.28 1.60E-04 6.90E-03 ENSG00000162520 SYNC -1.07 -5.28 1.60E-04 6.90E-03 ENSG00000148842 CNNM2 1.57 5.27 1.70E-04 7.00E-03 ENSG00000119599 DCAF4 -1.69 -5.27 1.70E-04 7.00E-03 ENSG00000137776 SLTM 0.83 5.27 1.70E-04 7.00E-03 ENSG00000117481 NSUN4 -1.14 -5.26 1.70E-04 7.00E-03 ENSG00000133065 SLC41A1 1.56 5.26 1.70E-04 7.00E-03 ENSG00000174740 PABPC5 -1.6 -5.26 1.70E-04 7.00E-03 ENSG00000198231 DDX42 -0.82 -5.26 1.70E-04 7.00E-03 ENSG00000139651 ZNF740 1.36 5.24 1.70E-04 7.20E-03 ENSG00000134107 BHLHE40 -1.91 -5.24 1.80E-04 7.20E-03 ENSG00000151718 WWC2 1.6 5.23 1.80E-04 7.30E-03 ENSG00000198604 BAZ1A 1.35 5.22 1.80E-04 7.40E-03 ENSG00000112855 HARS2 -0.85 -5.21 1.80E-04 7.40E-03 ENSG00000184481 FOXO4 1.93 5.21 1.80E-04 7.40E-03 ENSG00000177352 CCDC71 -1.88 -5.21 1.80E-04 7.40E-03 ENSG00000130305 NSUN5 -1.7 -5.21 1.80E-04 7.40E-03 ENSG00000167554 ZNF610 -1.88 -5.21 1.80E-04 7.40E-03 ENSG00000108861 DUSP3 0.96 5.2 1.90E-04 7.40E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000153922 CHD1 0.91 5.2 1.90E-04 7.40E-03 ENSG00000175215 CTDSP2 1.24 5.2 1.90E-04 7.50E-03 ENSG00000138764 CCNG2 1.32 5.2 1.90E-04 7.50E-03 ENSG00000174197 MGA -0.67 -5.2 1.90E-04 7.50E-03 ENSG00000153443 FAM100A 1.95 5.19 1.90E-04 7.50E-03 ENSG00000112308 C6orf62 -0.91 -5.19 1.90E-04 7.50E-03 ENSG00000173295 FAM86B3P -3.57 -5.18 1.90E-04 7.60E-03 ENSG00000127989 MTERF -0.99 -5.18 1.90E-04 7.60E-03 ENSG00000143384 MCL1 0.96 5.18 1.90E-04 7.60E-03 ENSG00000170855 TRIAP1 -1.07 -5.16 2.00E-04 7.80E-03 ENSG00000164463 CREBRF 2.16 5.16 2.00E-04 7.80E-03 ENSG00000143995 MEIS1 -1.34 -5.15 2.00E-04 7.80E-03 ENSG00000175087 PDIK1L -1.02 -5.15 2.00E-04 7.80E-03 ENSG00000108312 UBTF -1.23 -5.15 2.00E-04 7.80E-03 ENSG00000126070 EIF2C3 1.02 5.14 2.10E-04 7.90E-03 ENSG00000131475 VPS25 -0.86 -5.14 2.10E-04 7.90E-03 ENSG00000261050 . 2.37 5.14 2.10E-04 7.90E-03 ENSG00000173276 ZNF295 -1.84 -5.14 2.10E-04 7.90E-03 ENSG00000102786 INTS6 0.8 5.14 2.10E-04 7.90E-03 ENSG00000100711 ZFYVE21 -1.08 -5.13 2.10E-04 8.00E-03 ENSG00000165219 GAPVD1 0.86 5.13 2.10E-04 8.00E-03 ENSG00000103942 HOMER2 -1.25 -5.12 2.10E-04 8.00E-03 ENSG00000176095 IP6K1 1.08 5.12 2.10E-04 8.00E-03 ENSG00000151611 MMAA -1.76 -5.12 2.10E-04 8.00E-03 ENSG00000260966 . -1.25 -5.12 2.20E-04 8.10E-03 ENSG00000117616 C1orf63 1.44 5.11 2.20E-04 8.10E-03 ENSG00000128694 OSGEPL1 -1.56 -5.11 2.20E-04 8.10E-03 ENSG00000087074 PPP1R15A 1.63 5.11 2.20E-04 8.10E-03 ENSG00000264469 . 2.2 5.1 2.20E-04 8.20E-03 ENSG00000115020 PIKFYVE 0.87 5.1 2.20E-04 8.20E-03 ENSG00000108669 CYTH1 1.03 5.1 2.20E-04 8.20E-03 ENSG00000125733 TRIP10 1.74 5.1 2.20E-04 8.20E-03 ENSG00000147324 MFHAS1 1.75 5.08 2.30E-04 8.40E-03 ENSG00000102096 PIM2 2.22 5.08 2.30E-04 8.40E-03 ENSG00000160570 DEDD2 1.18 5.08 2.30E-04 8.40E-03 ENSG00000148444 COMMD3 -1.27 -5.08 2.30E-04 8.40E-03 ENSG00000112406 HECA 1.22 5.07 2.30E-04 8.40E-03 ENSG00000130449 ZSWIM6 0.97 5.07 2.30E-04 8.40E-03 ENSG00000144674 GOLGA4 0.95 5.06 2.40E-04 8.60E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000163170 BOLA3 -1.29 -5.06 2.40E-04 8.60E-03 ENSG00000169193 CCDC126 1.42 5.05 2.40E-04 8.60E-03 ENSG00000259877 . -2.02 -5.05 2.40E-04 8.60E-03 ENSG00000136866 ZFP37 -1.08 -5.05 2.40E-04 8.70E-03 ENSG00000177873 ZNF619 -2.99 -5.05 2.40E-04 8.70E-03 ENSG00000260267 . -1.85 -5.04 2.40E-04 8.70E-03 ENSG00000152409 JMY 0.84 5.04 2.50E-04 8.70E-03 ENSG00000165699 TSC1 0.95 5.04 2.50E-04 8.70E-03 ENSG00000078902 TOLLIP 1.14 5.04 2.50E-04 8.70E-03 ENSG00000146834 MEPCE 0.98 5.04 2.50E-04 8.70E-03 ENSG00000166192 SENP8 -1.93 -5.03 2.50E-04 8.70E-03 ENSG00000083312 TNPO1 0.78 5.03 2.50E-04 8.70E-03 ENSG00000151151 IPMK 1.26 5.03 2.50E-04 8.70E-03 ENSG00000085449 WDFY1 -0.74 -5.03 2.50E-04 8.70E-03 ENSG00000005801 ZNF195 -1.08 -5.03 2.50E-04 8.70E-03 ENSG00000125772 GPCPD1 -2.14 -5.03 2.50E-04 8.70E-03 ENSG00000102743 SLC25A15 -1.4 -5.03 2.50E-04 8.70E-03 ENSG00000162852 CNST 1 5.02 2.50E-04 8.70E-03 ENSG00000183060 LYSMD4 -1.62 -5.02 2.50E-04 8.70E-03 ENSG00000123505 AMD1 1.55 5.02 2.60E-04 8.80E-03 ENSG00000100330 MTMR3 1.1 5.01 2.60E-04 8.90E-03 ENSG00000065491 TBC1D22B 1.35 5.01 2.60E-04 8.90E-03 ENSG00000242125 SNHG3 1.07 5.01 2.60E-04 8.90E-03 ENSG00000214046 SMIM7 -1.02 -5.01 2.60E-04 8.90E-03 ENSG00000170322 NFRKB 0.96 5 2.60E-04 8.90E-03 ENSG00000176994 SMCR8 1.22 5 2.70E-04 9.00E-03 ENSG00000116754 SRSF11 0.72 4.99 2.70E-04 9.00E-03 ENSG00000125266 EFNB2 1.39 4.99 2.70E-04 9.00E-03 ENSG00000178150 ZNF114 -3.04 -4.99 2.70E-04 9.00E-03 ENSG00000217128 FNIP1 1.3 4.99 2.70E-04 9.00E-03 ENSG00000103356 EARS2 -0.93 -4.99 2.70E-04 9.00E-03 ENSG00000121481 RNF2 -1.08 -4.98 2.70E-04 9.00E-03 ENSG00000136527 TRA2B -0.89 -4.98 2.70E-04 9.10E-03 ENSG00000167747 C19orf48 -1.23 -4.97 2.80E-04 9.20E-03 ENSG00000149313 AASDHPPT -0.77 -4.96 2.80E-04 9.30E-03 ENSG00000173991 TCAP 2.81 4.95 2.90E-04 9.50E-03 ENSG00000183935 HTR7P1 -2.96 -4.94 2.90E-04 9.60E-03 ENSG00000198026 ZNF335 1.37 4.94 2.90E-04 9.70E-03 ENSG00000073605 GSDMB 1.62 4.94 3.00E-04 9.70E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000164815 ORC5 -1.01 -4.93 3.00E-04 9.70E-03 ENSG00000115966 ATF2 0.96 4.93 3.00E-04 9.70E-03 ENSG00000173230 GOLGB1 0.99 4.92 3.00E-04 9.80E-03 ENSG00000157540 DYRK1A 0.8 4.92 3.00E-04 9.80E-03 ENSG00000099364 FBXL19 1.68 4.92 3.00E-04 9.80E-03 ENSG00000106028 SSBP1 -0.71 -4.91 3.10E-04 9.90E-03 ENSG00000125484 GTF3C4 0.89 4.91 3.10E-04 9.90E-03 ENSG00000035141 FAM136A -0.91 -4.91 3.10E-04 1.00E-02 ENSG00000198000 NOL8 -1.17 -4.91 3.10E-04 1.00E-02 ENSG00000101191 DIDO1 0.74 4.9 3.10E-04 1.00E-02 ENSG00000112511 PHF1 0.99 4.9 3.10E-04 1.00E-02 ENSG00000197063 MAFG 1.65 4.9 3.20E-04 1.00E-02 ENSG00000261167 . -1.68 -4.89 3.20E-04 1.00E-02 ENSG00000204315 FKBPL 1.52 4.88 3.30E-04 1.00E-02 ENSG00000175054 ATR -0.87 -4.88 3.30E-04 1.00E-02 ENSG00000122299 ZC3H7A 0.89 4.88 3.30E-04 1.00E-02 ENSG00000131779 PEX11B -1.12 -4.87 3.30E-04 1.00E-02 ENSG00000165626 BEND7 1.38 4.87 3.30E-04 1.00E-02 ENSG00000085760 MTIF2 -1.01 -4.87 3.30E-04 1.00E-02 ENSG00000174111 SOCS7 1.15 4.87 3.30E-04 1.00E-02 ENSG00000179240 . -1.28 -4.86 3.30E-04 1.00E-02 ENSG00000143748 NVL -0.84 -4.86 3.40E-04 1.00E-02 ENSG00000115758 ODC1 -0.69 -4.86 3.40E-04 1.00E-02 ENSG00000138279 ANXA7 -0.88 -4.86 3.40E-04 1.00E-02 ENSG00000105204 DYRK1B 1.72 4.85 3.40E-04 1.00E-02 ENSG00000156875 HIAT1 0.75 4.85 3.40E-04 1.00E-02 ENSG00000104381 GDAP1 -0.91 -4.85 3.40E-04 1.00E-02 ENSG00000196659 TTC30B -1.79 -4.85 3.40E-04 1.00E-02 ENSG00000125107 CNOT1 0.89 4.85 3.40E-04 1.00E-02 ENSG00000197013 ZNF429 -1.43 -4.85 3.40E-04 1.10E-02 ENSG00000096717 SIRT1 1.53 4.85 3.40E-04 1.10E-02 ENSG00000124356 STAMBP -0.67 -4.85 3.40E-04 1.10E-02 ENSG00000148634 HERC4 1 4.84 3.50E-04 1.10E-02 ENSG00000089737 DDX24 -0.63 -4.84 3.50E-04 1.10E-02 ENSG00000188938 FAM120AOS -1.05 -4.84 3.50E-04 1.10E-02 ENSG00000104064 GABPB1 1 4.84 3.50E-04 1.10E-02 ENSG00000211460 TSN -0.62 -4.84 3.50E-04 1.10E-02 ENSG00000072422 RHOBTB1 -1.15 -4.84 3.50E-04 1.10E-02 ENSG00000164338 UTP15 -0.87 -4.83 3.50E-04 1.10E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000187801 ZNF643 -2.18 -4.83 3.50E-04 1.10E-02 ENSG00000163605 PPP4R2 0.76 4.83 3.60E-04 1.10E-02 ENSG00000106415 GLCCI1 1.92 4.82 3.60E-04 1.10E-02 ENSG00000166199 ALKBH3 -0.99 -4.81 3.70E-04 1.10E-02 ENSG00000175155 YPEL2 2.01 4.81 3.70E-04 1.10E-02 ENSG00000165997 ARL5B 0.72 4.8 3.70E-04 1.10E-02 ENSG00000168298 HIST1H1E -1.7 -4.8 3.80E-04 1.10E-02 ENSG00000003393 ALS2 1.13 4.8 3.80E-04 1.10E-02 ENSG00000260349 . -1.44 -4.79 3.80E-04 1.10E-02 ENSG00000130159 ECSIT 1.01 4.79 3.80E-04 1.10E-02 ENSG00000160767 FAM189B 1.9 4.79 3.80E-04 1.10E-02 ENSG00000108039 XPNPEP1 -0.81 -4.79 3.80E-04 1.10E-02 ENSG00000144395 CCDC150 1.67 4.79 3.80E-04 1.10E-02 ENSG00000154642 C21orf91 1.04 4.78 3.90E-04 1.10E-02 ENSG00000132155 RAF1 0.67 4.78 3.90E-04 1.10E-02 ENSG00000167637 ZNF283 -0.9 -4.78 3.90E-04 1.10E-02 ENSG00000160741 CRTC2 1.77 4.77 3.90E-04 1.10E-02 ENSG00000177383 MAGEF1 -0.76 -4.77 3.90E-04 1.10E-02 ENSG00000164631 ZNF12 -0.79 -4.77 4.00E-04 1.10E-02 ENSG00000228315 GUSBP11 0.91 4.77 4.00E-04 1.10E-02 ENSG00000006025 OSBPL7 -1.36 -4.76 4.00E-04 1.10E-02 ENSG00000165417 GTF2A1 -0.77 -4.76 4.00E-04 1.10E-02 ENSG00000110713 NUP98 0.76 4.76 4.00E-04 1.10E-02 ENSG00000174791 RIN1 -2.54 -4.76 4.00E-04 1.10E-02 ENSG00000183250 C21orf67 -2.51 -4.76 4.00E-04 1.10E-02 ENSG00000213976 . 2.42 4.76 4.00E-04 1.10E-02 ENSG00000137547 MRPL15 -1.21 -4.76 4.00E-04 1.10E-02 ENSG00000108306 FBXL20 1.01 4.75 4.10E-04 1.20E-02 ENSG00000143633 C1orf131 -1.18 -4.75 4.10E-04 1.20E-02 ENSG00000117000 RLF 0.77 4.75 4.10E-04 1.20E-02 ENSG00000221883 ARIH2OS -2.05 -4.74 4.10E-04 1.20E-02 ENSG00000204611 ZNF616 -1.08 -4.74 4.20E-04 1.20E-02 ENSG00000198498 TMA16 -1.28 -4.73 4.20E-04 1.20E-02 ENSG00000135999 EPC2 0.91 4.73 4.20E-04 1.20E-02 ENSG00000180357 ZNF609 1.18 4.72 4.30E-04 1.20E-02 ENSG00000070010 UFD1L 0.67 4.72 4.30E-04 1.20E-02 ENSG00000123178 SPRYD7 -1.12 -4.72 4.30E-04 1.20E-02 ENSG00000169914 OTUD3 0.95 4.72 4.30E-04 1.20E-02 ENSG00000164114 MAP9 -1 -4.71 4.30E-04 1.20E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000169242 EFNA1 -1.38 -4.71 4.40E-04 1.20E-02 ENSG00000166704 ZNF606 -0.98 -4.71 4.40E-04 1.20E-02 ENSG00000125650 PSPN 1.39 4.71 4.40E-04 1.20E-02 ENSG00000172409 CLP1 0.92 4.71 4.40E-04 1.20E-02 ENSG00000149050 ZNF214 -1.65 -4.71 4.40E-04 1.20E-02 ENSG00000171105 INSR 0.98 4.7 4.50E-04 1.20E-02 ENSG00000197989 SNHG12 1.57 4.69 4.50E-04 1.20E-02 ENSG00000105229 PIAS4 1.19 4.69 4.50E-04 1.20E-02 ENSG00000075292 ZNF638 0.72 4.69 4.60E-04 1.20E-02 ENSG00000169598 DFFB 1.22 4.69 4.60E-04 1.20E-02 ENSG00000183475 ASB7 1 4.68 4.60E-04 1.20E-02 ENSG00000260948 . 2.35 4.68 4.60E-04 1.20E-02 ENSG00000172840 PDP2 1.18 4.68 4.60E-04 1.20E-02 ENSG00000180667 YOD1 1.27 4.68 4.60E-04 1.20E-02 ENSG00000102710 FAM48A -1.03 -4.68 4.60E-04 1.20E-02 ENSG00000174106 LEMD3 0.76 4.68 4.60E-04 1.20E-02 ENSG00000105085 MED26 1.55 4.68 4.60E-04 1.20E-02 ENSG00000160703 NLRX1 -1.93 -4.67 4.70E-04 1.20E-02 ENSG00000156398 SFXN2 -1.84 -4.67 4.70E-04 1.20E-02 ENSG00000156384 SFR1 -1.68 -4.67 4.70E-04 1.20E-02 ENSG00000083896 YTHDC1 0.6 4.67 4.70E-04 1.20E-02 ENSG00000086061 DNAJA1 0.85 4.67 4.70E-04 1.20E-02 ENSG00000100105 PATZ1 -1.32 -4.66 4.80E-04 1.30E-02 ENSG00000204386 NEU1 0.92 4.66 4.80E-04 1.30E-02 ENSG00000267548 . 1.24 4.66 4.80E-04 1.30E-02 ENSG00000221990 C5orf55 -1.72 -4.66 4.80E-04 1.30E-02 ENSG00000133789 SWAP70 1.19 4.65 4.80E-04 1.30E-02 ENSG00000105732 ZNF574 1.4 4.65 4.80E-04 1.30E-02 ENSG00000132481 TRIM47 -2.31 -4.65 4.90E-04 1.30E-02 ENSG00000170903 MSANTD4 -0.74 -4.64 5.00E-04 1.30E-02 ENSG00000187790 FANCM 1.43 4.63 5.00E-04 1.30E-02 ENSG00000089163 SIRT4 2.36 4.63 5.00E-04 1.30E-02 ENSG00000167695 FAM57A -1.08 -4.63 5.10E-04 1.30E-02 ENSG00000196437 ZNF569 -1.08 -4.63 5.10E-04 1.30E-02 ENSG00000130254 SAFB2 1.07 4.63 5.10E-04 1.30E-02 ENSG00000160194 NDUFV3 -0.84 -4.62 5.10E-04 1.30E-02 ENSG00000113369 ARRDC3 -2.12 -4.62 5.10E-04 1.30E-02 ENSG00000211456 SACM1L 0.79 4.62 5.20E-04 1.30E-02 ENSG00000205581 HMGN1 -0.82 -4.62 5.20E-04 1.30E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000112394 SLC16A10 2.34 4.61 5.20E-04 1.30E-02 ENSG00000164323 KIAA1430 -0.74 -4.61 5.20E-04 1.30E-02 ENSG00000128881 TTBK2 1.08 4.61 5.20E-04 1.30E-02 ENSG00000204130 RUFY2 -0.61 -4.61 5.20E-04 1.30E-02 ENSG00000104375 STK3 1.47 4.6 5.30E-04 1.40E-02 ENSG00000151366 NDUFC2 -0.98 -4.6 5.40E-04 1.40E-02 ENSG00000147475 ERLIN2 -1.23 -4.59 5.40E-04 1.40E-02 ENSG00000167186 COQ7 -0.79 -4.59 5.40E-04 1.40E-02 ENSG00000198909 MAP3K3 1.1 4.59 5.40E-04 1.40E-02 ENSG00000154764 WNT7A -2.18 -4.59 5.50E-04 1.40E-02 ENSG00000011021 CLCN6 1.48 4.58 5.50E-04 1.40E-02 ENSG00000254996 ANKHD1-EIF4EBP3 1.53 4.58 5.50E-04 1.40E-02 ENSG00000134644 PUM1 0.87 4.58 5.50E-04 1.40E-02 ENSG00000025156 HSF2 0.79 4.58 5.60E-04 1.40E-02 ENSG00000160305 DIP2A 0.85 4.58 5.60E-04 1.40E-02 ENSG00000264058 . -2.22 -4.57 5.60E-04 1.40E-02 ENSG00000134668 SPOCD1 -3.01 -4.57 5.70E-04 1.40E-02 ENSG00000162613 FUBP1 0.78 4.56 5.70E-04 1.40E-02 ENSG00000186272 ZNF17 -1.11 -4.56 5.70E-04 1.40E-02 ENSG00000186842 C21orf77 3.03 4.56 5.70E-04 1.40E-02 ENSG00000162714 ZNF496 0.89 4.56 5.70E-04 1.40E-02 ENSG00000173120 KDM2A 0.97 4.55 5.80E-04 1.40E-02 ENSG00000136802 LRRC8A 1.02 4.55 5.80E-04 1.40E-02 ENSG00000090263 MRPS33 -0.9 -4.55 5.90E-04 1.40E-02 ENSG00000181744 C3orf58 1.27 4.55 5.90E-04 1.40E-02 ENSG00000180488 FAM73A -0.95 -4.54 5.90E-04 1.40E-02 ENSG00000104081 BMF 2.09 4.54 5.90E-04 1.40E-02 ENSG00000109220 CHIC2 1.1 4.54 5.90E-04 1.50E-02 ENSG00000108256 NUFIP2 0.83 4.54 6.00E-04 1.50E-02 ENSG00000069956 MAPK6 -0.88 -4.54 6.00E-04 1.50E-02 ENSG00000130544 ZNF557 -0.9 -4.53 6.00E-04 1.50E-02 ENSG00000198879 SFMBT2 -0.95 -4.53 6.00E-04 1.50E-02 ENSG00000165240 ATP7A 0.89 4.53 6.00E-04 1.50E-02 ENSG00000100201 DDX17 0.86 4.53 6.10E-04 1.50E-02 ENSG00000174010 KLHL15 0.89 4.52 6.10E-04 1.50E-02 ENSG00000141569 TRIM65 -1.47 -4.52 6.10E-04 1.50E-02 ENSG00000108826 MRPL27 -0.71 -4.52 6.20E-04 1.50E-02 ENSG00000141337 ARSG -1.77 -4.51 6.20E-04 1.50E-02 ENSG00000144357 UBR3 0.63 4.51 6.30E-04 1.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000254685 FPGT -1.69 -4.51 6.30E-04 1.50E-02 ENSG00000197062 . -0.81 -4.5 6.40E-04 1.50E-02 ENSG00000085465 OVGP1 2.73 4.5 6.40E-04 1.50E-02 ENSG00000119929 CUTC -0.96 -4.5 6.40E-04 1.50E-02 ENSG00000130758 MAP3K10 1.59 4.5 6.40E-04 1.50E-02 ENSG00000130734 ATG4D 1.52 4.5 6.40E-04 1.50E-02 ENSG00000166189 HPS6 -1.15 -4.49 6.40E-04 1.50E-02 ENSG00000007866 TEAD3 1.27 4.49 6.50E-04 1.50E-02 ENSG00000059728 MXD1 1.51 4.49 6.50E-04 1.50E-02 ENSG00000160221 C21orf33 -0.9 -4.48 6.60E-04 1.50E-02 ENSG00000197894 ADH5 -0.81 -4.48 6.60E-04 1.50E-02 ENSG00000242485 MRPL20 -0.77 -4.48 6.60E-04 1.50E-02 ENSG00000152944 MED21 1.02 4.48 6.60E-04 1.50E-02 ENSG00000141582 CBX4 -1.09 -4.48 6.60E-04 1.50E-02 ENSG00000126804 ZBTB1 0.68 4.48 6.60E-04 1.50E-02 ENSG00000197608 ZNF841 -1.34 -4.48 6.60E-04 1.50E-02 ENSG00000164219 PGGT1B -0.79 -4.48 6.60E-04 1.50E-02 ENSG00000170006 TMEM154 -2.92 -4.48 6.70E-04 1.50E-02 ENSG00000136021 SCYL2 0.68 4.48 6.70E-04 1.50E-02 ENSG00000073792 IGF2BP2 1.06 4.48 6.70E-04 1.50E-02 ENSG00000087448 KLHDC5 -0.9 -4.47 6.70E-04 1.50E-02 ENSG00000006530 AGK -0.73 -4.47 6.70E-04 1.50E-02 ENSG00000217576 . -1.08 -4.47 6.70E-04 1.50E-02 ENSG00000166004 KIAA1731 -0.79 -4.47 6.70E-04 1.50E-02 ENSG00000119285 HEATR1 -0.6 -4.47 6.80E-04 1.60E-02 ENSG00000196741 CXorf24 -2.07 -4.47 6.80E-04 1.60E-02 ENSG00000119801 YPEL5 0.82 4.47 6.80E-04 1.60E-02 ENSG00000065883 CDK13 0.57 4.46 6.80E-04 1.60E-02 ENSG00000101134 DOK5 1.09 4.46 6.80E-04 1.60E-02 ENSG00000147162 OGT 0.73 4.46 6.80E-04 1.60E-02 ENSG00000086102 NFX1 -0.9 -4.46 6.90E-04 1.60E-02 ENSG00000102103 PQBP1 1.05 4.46 6.90E-04 1.60E-02 ENSG00000176108 CHMP6 -1.44 -4.46 6.90E-04 1.60E-02 ENSG00000088448 ANKRD10 0.7 4.45 6.90E-04 1.60E-02 ENSG00000164011 ZNF691 -1.63 -4.45 7.00E-04 1.60E-02 ENSG00000166439 RNF169 0.94 4.45 7.00E-04 1.60E-02 ENSG00000198746 GPATCH3 1.17 4.45 7.00E-04 1.60E-02 ENSG00000135632 SMYD5 -0.77 -4.45 7.00E-04 1.60E-02 ENSG00000078699 CBFA2T2 0.9 4.45 7.00E-04 1.60E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000117676 RPS6KA1 2.13 4.45 7.00E-04 1.60E-02 ENSG00000236901 MIR600HG 1.49 4.44 7.10E-04 1.60E-02 ENSG00000186866 POFUT2 0.95 4.43 7.20E-04 1.60E-02 ENSG00000145604 SKP2 -1.29 -4.43 7.20E-04 1.60E-02 ENSG00000137038 C9orf123 -1.02 -4.43 7.30E-04 1.60E-02 ENSG00000124641 MED20 -0.81 -4.42 7.40E-04 1.60E-02 ENSG00000165861 ZFYVE1 0.86 4.42 7.40E-04 1.60E-02 ENSG00000156140 ADAMTS3 -1.47 -4.42 7.40E-04 1.60E-02 ENSG00000132406 TMEM128 -0.93 -4.42 7.40E-04 1.60E-02 ENSG00000109606 DHX15 0.68 4.42 7.40E-04 1.60E-02 ENSG00000121892 PDS5A 0.64 4.42 7.40E-04 1.60E-02 ENSG00000133639 BTG1 1.42 4.41 7.40E-04 1.60E-02 ENSG00000062725 APPBP2 0.59 4.41 7.40E-04 1.60E-02 ENSG00000198586 TLK1 -1.04 -4.41 7.50E-04 1.60E-02 ENSG00000064102 ASUN 1.08 4.4 7.60E-04 1.70E-02 ENSG00000267100 ILF3-AS1 -1.22 -4.4 7.60E-04 1.70E-02 ENSG00000255529 POLR2M -0.86 -4.4 7.60E-04 1.70E-02 ENSG00000087338 GMCL1 0.85 4.4 7.70E-04 1.70E-02 ENSG00000205913 SRRM2-AS1 -2.47 -4.39 7.70E-04 1.70E-02 ENSG00000146540 C7orf50 -0.83 -4.39 7.70E-04 1.70E-02 ENSG00000153487 ING1 1.13 4.39 7.80E-04 1.70E-02 ENSG00000121274 PAPD5 1.16 4.39 7.80E-04 1.70E-02 ENSG00000112357 PEX7 -1.29 -4.39 7.80E-04 1.70E-02 ENSG00000145246 ATP10D 0.84 4.38 7.90E-04 1.70E-02 ENSG00000104524 PYCRL -1.43 -4.38 7.90E-04 1.70E-02 ENSG00000114416 FXR1 0.71 4.38 7.90E-04 1.70E-02 ENSG00000116560 SFPQ 0.65 4.38 7.90E-04 1.70E-02 ENSG00000124104 SNX21 -1.15 -4.38 8.00E-04 1.70E-02 ENSG00000101624 CEP76 0.94 4.37 8.00E-04 1.70E-02 ENSG00000058063 ATP11B 0.68 4.37 8.10E-04 1.70E-02 ENSG00000188242 . -1.31 -4.37 8.10E-04 1.70E-02 ENSG00000122481 RWDD3 -1.01 -4.37 8.10E-04 1.70E-02 ENSG00000103351 CLUAP1 -1.09 -4.37 8.10E-04 1.70E-02 ENSG00000146757 ZNF92 -0.99 -4.36 8.20E-04 1.70E-02 ENSG00000204947 ZNF425 -1.3 -4.36 8.20E-04 1.70E-02 ENSG00000163728 TTC14 -0.86 -4.36 8.20E-04 1.70E-02 ENSG00000117525 F3 -1.73 -4.36 8.20E-04 1.70E-02 ENSG00000140006 WDR89 -1.18 -4.36 8.20E-04 1.70E-02 ENSG00000117682 DHDDS -1.08 -4.36 8.20E-04 1.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000164576 SAP30L 1.49 4.36 8.20E-04 1.70E-02 ENSG00000125962 ARMCX5 -1.22 -4.36 8.30E-04 1.70E-02 ENSG00000159256 MORC3 0.96 4.36 8.30E-04 1.70E-02 ENSG00000129245 FXR2 1.01 4.35 8.30E-04 1.70E-02 ENSG00000176842 IRX5 1.34 4.35 8.30E-04 1.70E-02 ENSG00000198551 ZNF627 -0.84 -4.35 8.40E-04 1.80E-02 ENSG00000159433 STARD9 1.03 4.35 8.40E-04 1.80E-02 ENSG00000189369 GSPT2 -0.88 -4.34 8.50E-04 1.80E-02 ENSG00000158158 CNNM4 1.24 4.34 8.50E-04 1.80E-02 ENSG00000174529 TMEM81 1.66 4.34 8.60E-04 1.80E-02 ENSG00000155729 KCTD18 -0.87 -4.33 8.60E-04 1.80E-02 ENSG00000061938 TNK2 1.28 4.33 8.70E-04 1.80E-02 ENSG00000106305 AIMP2 -1.02 -4.32 8.80E-04 1.80E-02 ENSG00000257511 . 2.36 4.32 8.90E-04 1.80E-02 ENSG00000181690 PLAG1 1.71 4.32 8.90E-04 1.80E-02 ENSG00000047621 C12orf4 -0.83 -4.31 8.90E-04 1.80E-02 ENSG00000107816 LZTS2 0.85 4.31 9.00E-04 1.80E-02 ENSG00000066739 ATG2B 0.72 4.31 9.10E-04 1.90E-02 ENSG00000204623 ZNRD1-AS1 -1.39 -4.3 9.10E-04 1.90E-02 ENSG00000163528 CHCHD4 -1.18 -4.3 9.10E-04 1.90E-02 ENSG00000173926 3-Mar 1.55 4.3 9.10E-04 1.90E-02 ENSG00000163877 SNIP1 0.79 4.3 9.10E-04 1.90E-02 ENSG00000160193 WDR4 -1.7 -4.3 9.20E-04 1.90E-02 ENSG00000173566 NUDT18 -1.91 -4.3 9.20E-04 1.90E-02 ENSG00000001084 GCLC 0.85 4.3 9.20E-04 1.90E-02 ENSG00000143622 RIT1 0.94 4.29 9.30E-04 1.90E-02 ENSG00000148158 SNX30 1.04 4.29 9.30E-04 1.90E-02 ENSG00000081913 PHLPP1 1.45 4.29 9.30E-04 1.90E-02 ENSG00000186283 TOR3A -1.07 -4.29 9.30E-04 1.90E-02 ENSG00000111266 DUSP16 1.38 4.29 9.30E-04 1.90E-02 ENSG00000074266 EED 0.82 4.29 9.40E-04 1.90E-02 ENSG00000130349 C6orf203 -1.13 -4.29 9.40E-04 1.90E-02 ENSG00000100916 BRMS1L 0.87 4.29 9.40E-04 1.90E-02 ENSG00000147419 CCDC25 -0.72 -4.29 9.40E-04 1.90E-02 ENSG00000134452 FBXO18 0.73 4.28 9.50E-04 1.90E-02 ENSG00000009780 FAM76A -1.08 -4.28 9.50E-04 1.90E-02 ENSG00000264098 . 1.89 4.28 9.60E-04 1.90E-02 ENSG00000186448 ZNF197 -0.6 -4.28 9.60E-04 1.90E-02 ENSG00000111790 FGFR1OP2 0.88 4.28 9.60E-04 1.90E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000168237 GLYCTK -1.44 -4.27 9.70E-04 1.90E-02 ENSG00000121104 FAM117A 1.66 4.27 9.70E-04 1.90E-02 ENSG00000213020 ZNF611 -1.09 -4.27 9.70E-04 1.90E-02 ENSG00000180423 HARBI1 -1.44 -4.26 9.80E-04 1.90E-02 ENSG00000171970 ZNF57 -1.67 -4.26 9.80E-04 1.90E-02 ENSG00000197782 ZNF780A -1 -4.26 9.90E-04 2.00E-02 ENSG00000143756 FBXO28 0.57 4.26 9.90E-04 2.00E-02 ENSG00000245651 . -2.7 -4.25 1.00E-03 2.00E-02 ENSG00000132773 TOE1 -1.46 -4.25 1.00E-03 2.00E-02 ENSG00000185950 IRS2 1.21 4.25 1.00E-03 2.00E-02 ENSG00000107854 TNKS2 0.85 4.25 1.00E-03 2.00E-02 ENSG00000149187 CELF1 0.6 4.25 1.00E-03 2.00E-02 ENSG00000106346 USP42 1.12 4.25 1.00E-03 2.00E-02 ENSG00000182141 ZNF708 -0.78 -4.25 1.00E-03 2.00E-02 ENSG00000178809 TRIM73 1.55 4.25 1.00E-03 2.00E-02 ENSG00000163961 RNF168 0.83 4.24 1.00E-03 2.00E-02 ENSG00000106785 TRIM14 2.45 4.24 1.00E-03 2.00E-02 ENSG00000114491 UMPS -0.99 -4.24 1.00E-03 2.00E-02 ENSG00000229729 . 1.53 4.24 1.00E-03 2.00E-02 ENSG00000122550 KLHL7 0.86 4.23 1.00E-03 2.00E-02 ENSG00000171161 ZNF672 1.03 4.23 1.00E-03 2.00E-02 ENSG00000181104 F2R -0.82 -4.23 1.00E-03 2.00E-02 ENSG00000120137 PANK3 0.75 4.23 1.00E-03 2.00E-02 ENSG00000120690 ELF1 1.2 4.22 1.10E-03 2.00E-02 ENSG00000129055 ANAPC13 -0.68 -4.22 1.10E-03 2.00E-02 ENSG00000113643 RARS -0.73 -4.22 1.10E-03 2.10E-02 ENSG00000131379 C3orf20 2.79 4.22 1.10E-03 2.10E-02 ENSG00000113240 CLK4 1 4.22 1.10E-03 2.10E-02 ENSG00000214029 ZNF891 -1.26 -4.21 1.10E-03 2.10E-02 ENSG00000104231 ZFAND1 -1.35 -4.21 1.10E-03 2.10E-02 ENSG00000254473 . -1.94 -4.21 1.10E-03 2.10E-02 ENSG00000198862 LTN1 0.66 4.2 1.10E-03 2.10E-02 ENSG00000186951 PPARA 1.08 4.2 1.10E-03 2.10E-02 ENSG00000189298 ZKSCAN3 -1.2 -4.19 1.10E-03 2.10E-02 ENSG00000269044 . -1.64 -4.19 1.10E-03 2.10E-02 ENSG00000077454 LRCH4 1.4 4.19 1.10E-03 2.10E-02 ENSG00000062194 GPBP1 0.75 4.19 1.10E-03 2.10E-02 ENSG00000176390 CRLF3 1.03 4.19 1.10E-03 2.10E-02 ENSG00000165338 HECTD2 -0.79 -4.18 1.10E-03 2.10E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000196227 FAM217B -1.61 -4.18 1.20E-03 2.20E-02 ENSG00000011258 MBTD1 0.78 4.18 1.20E-03 2.20E-02 ENSG00000138035 PNPT1 -0.8 -4.17 1.20E-03 2.20E-02 ENSG00000204859 ZBTB48 -1.15 -4.17 1.20E-03 2.20E-02 ENSG00000104497 SNX16 1.71 4.17 1.20E-03 2.20E-02 ENSG00000068323 TFE3 0.76 4.17 1.20E-03 2.20E-02 ENSG00000260391 . 1.98 4.17 1.20E-03 2.20E-02 ENSG00000198218 QRICH1 0.59 4.16 1.20E-03 2.20E-02 ENSG00000104691 UBXN8 -1.1 -4.16 1.20E-03 2.20E-02 ENSG00000174738 NR1D2 1.04 4.16 1.20E-03 2.20E-02 ENSG00000267010 . 1.51 4.16 1.20E-03 2.20E-02 ENSG00000057294 PKP2 1.89 4.16 1.20E-03 2.20E-02 ENSG00000031003 FAM13B 0.58 4.16 1.20E-03 2.20E-02 ENSG00000205036 C16orf85 -1.64 -4.15 1.20E-03 2.20E-02 ENSG00000103404 USP31 0.92 4.15 1.20E-03 2.20E-02 ENSG00000173960 UBXN2A 0.67 4.14 1.20E-03 2.30E-02 ENSG00000137996 RTCA -0.86 -4.14 1.20E-03 2.30E-02 ENSG00000198420 FAM115A 0.69 4.13 1.20E-03 2.30E-02 ENSG00000133703 KRAS 0.7 4.13 1.30E-03 2.30E-02 ENSG00000173409 ARV1 -0.8 -4.13 1.30E-03 2.30E-02 ENSG00000131725 WDR44 0.76 4.13 1.30E-03 2.30E-02 ENSG00000119041 GTF3C3 -0.75 -4.12 1.30E-03 2.30E-02 ENSG00000168538 TRAPPC11 -0.69 -4.12 1.30E-03 2.30E-02 ENSG00000151806 GUF1 -0.75 -4.12 1.30E-03 2.30E-02 ENSG00000182149 IST1 0.55 4.12 1.30E-03 2.30E-02 ENSG00000111196 MAGOHB -1.2 -4.12 1.30E-03 2.30E-02 ENSG00000134698 EIF2C4 0.77 4.11 1.30E-03 2.30E-02 ENSG00000140948 ZCCHC14 0.86 4.11 1.30E-03 2.40E-02 ENSG00000151414 NEK7 1.12 4.11 1.30E-03 2.40E-02 ENSG00000170191 NANP 1.46 4.11 1.30E-03 2.40E-02 ENSG00000139372 TDG 0.81 4.1 1.30E-03 2.40E-02 ENSG00000101407 TTI1 -0.76 -4.1 1.30E-03 2.40E-02 ENSG00000123836 PFKFB2 -0.69 -4.1 1.30E-03 2.40E-02 ENSG00000138613 APH1B -1.12 -4.1 1.30E-03 2.40E-02 ENSG00000152520 PAN3 0.84 4.1 1.30E-03 2.40E-02 ENSG00000143498 TAF1A 1.07 4.09 1.30E-03 2.40E-02 ENSG00000139641 ESYT1 -0.61 -4.09 1.30E-03 2.40E-02 ENSG00000011295 TTC19 -0.63 -4.09 1.30E-03 2.40E-02 ENSG00000258289 CHURC1 -0.92 -4.09 1.30E-03 2.40E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000181788 SIAH2 0.97 4.09 1.40E-03 2.40E-02 ENSG00000095787 WAC 0.81 4.08 1.40E-03 2.40E-02 ENSG00000111481 COPZ1 -0.54 -4.08 1.40E-03 2.40E-02 ENSG00000067900 ROCK1 0.6 4.08 1.40E-03 2.40E-02 ENSG00000151883 PARP8 -0.97 -4.07 1.40E-03 2.50E-02 ENSG00000112365 ZBTB24 -1.11 -4.07 1.40E-03 2.50E-02 ENSG00000189266 PNRC2 0.7 4.06 1.40E-03 2.50E-02 ENSG00000145022 TCTA -1.43 -4.06 1.40E-03 2.50E-02 ENSG00000180346 TIGD2 -2.02 -4.06 1.40E-03 2.50E-02 ENSG00000123094 RASSF8 0.97 4.05 1.40E-03 2.60E-02 ENSG00000130695 CEP85 1.02 4.05 1.50E-03 2.60E-02 ENSG00000124479 NDP -1.92 -4.05 1.50E-03 2.60E-02 ENSG00000048028 USP28 1.1 4.04 1.50E-03 2.60E-02 ENSG00000198786 MT-ND5 -1.04 -4.04 1.50E-03 2.60E-02 ENSG00000106069 CHN2 2.19 4.04 1.50E-03 2.60E-02 ENSG00000132313 MRPL35 -0.87 -4.04 1.50E-03 2.60E-02 ENSG00000182180 MRPS16 -0.62 -4.04 1.50E-03 2.60E-02 ENSG00000213888 . -1.78 -4.04 1.50E-03 2.60E-02 ENSG00000137575 SDCBP 0.6 4.04 1.50E-03 2.60E-02 ENSG00000169241 SLC50A1 -1.44 -4.03 1.50E-03 2.60E-02 ENSG00000113916 BCL6 1.56 4.03 1.50E-03 2.60E-02 ENSG00000113583 C5orf15 -0.77 -4.03 1.50E-03 2.60E-02 ENSG00000109089 CDR2L 1.16 4.03 1.50E-03 2.60E-02 ENSG00000124164 VAPB -0.94 -4.03 1.50E-03 2.60E-02 ENSG00000148153 INIP -0.68 -4.03 1.50E-03 2.60E-02 ENSG00000221963 APOL6 -1.72 -4.03 1.50E-03 2.60E-02 ENSG00000095397 DFNB31 1.36 4.03 1.50E-03 2.60E-02 ENSG00000164022 AIMP1 -0.94 -4.02 1.50E-03 2.60E-02 ENSG00000182481 KPNA2 0.76 4.02 1.50E-03 2.60E-02 ENSG00000137474 MYO7A 1.79 4.02 1.50E-03 2.60E-02 ENSG00000196110 ZNF699 -0.85 -4.01 1.50E-03 2.70E-02 ENSG00000121073 SLC35B1 -0.63 -4.01 1.60E-03 2.70E-02 ENSG00000198952 SMG5 0.66 4.01 1.60E-03 2.70E-02 ENSG00000132664 POLR3F -0.84 -4.01 1.60E-03 2.70E-02 ENSG00000150593 PDCD4 1.13 4.01 1.60E-03 2.70E-02 ENSG00000073536 NLE1 -1.23 -4.01 1.60E-03 2.70E-02 ENSG00000176946 THAP4 0.81 4.01 1.60E-03 2.70E-02 ENSG00000113812 ACTR8 -0.83 -4.01 1.60E-03 2.70E-02 ENSG00000201558 . -2.98 -4.01 1.60E-03 2.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000171951 SCG2 -1.19 -4 1.60E-03 2.70E-02 ENSG00000113328 CCNG1 1.21 4 1.60E-03 2.70E-02 ENSG00000143353 LYPLAL1 -1.31 -4 1.60E-03 2.70E-02 ENSG00000121931 LRIF1 -0.99 -4 1.60E-03 2.70E-02 ENSG00000079335 CDC14A 1.62 4 1.60E-03 2.70E-02 ENSG00000136490 LIMD2 -1.19 -4 1.60E-03 2.70E-02 ENSG00000010818 HIVEP2 1.18 3.99 1.60E-03 2.70E-02 ENSG00000185670 ZBTB3 -1.03 -3.99 1.60E-03 2.70E-02 ENSG00000185019 UBOX5 -1.52 -3.99 1.60E-03 2.70E-02 ENSG00000106638 TBL2 -1.07 -3.99 1.60E-03 2.70E-02 ENSG00000108239 TBC1D12 0.8 3.98 1.60E-03 2.80E-02 ENSG00000114405 C3orf14 -1.22 -3.98 1.60E-03 2.80E-02 ENSG00000115526 CHST10 -0.87 -3.98 1.70E-03 2.80E-02 ENSG00000169047 IRS1 1.24 3.98 1.70E-03 2.80E-02 ENSG00000198324 FAM109A 1.07 3.97 1.70E-03 2.80E-02 ENSG00000153363 LINC00467 -1.49 -3.97 1.70E-03 2.80E-02 ENSG00000185127 C6orf120 -1.34 -3.97 1.70E-03 2.80E-02 ENSG00000196922 ZNF252P -0.64 -3.97 1.70E-03 2.80E-02 ENSG00000264247 . -1.03 -3.97 1.70E-03 2.80E-02 ENSG00000058091 CDK14 0.62 3.97 1.70E-03 2.80E-02 ENSG00000108061 SHOC2 0.56 3.96 1.70E-03 2.80E-02 ENSG00000136878 USP20 0.88 3.96 1.70E-03 2.80E-02 ENSG00000119906 FAM178A -1.12 -3.96 1.70E-03 2.80E-02 ENSG00000248866 USP46-AS1 -3.05 -3.96 1.70E-03 2.80E-02 ENSG00000017797 RALBP1 0.67 3.96 1.70E-03 2.80E-02 ENSG00000123358 NR4A1 2.37 3.96 1.70E-03 2.80E-02 ENSG00000011304 PTBP1 0.81 3.96 1.70E-03 2.80E-02 ENSG00000075391 RASAL2 0.83 3.96 1.70E-03 2.80E-02 ENSG00000102606 ARHGEF7 0.68 3.96 1.70E-03 2.90E-02 ENSG00000112996 MRPS30 -0.66 -3.95 1.70E-03 2.90E-02 ENSG00000108510 MED13 0.87 3.95 1.70E-03 2.90E-02 ENSG00000118689 FOXO3 0.76 3.95 1.70E-03 2.90E-02 ENSG00000144191 CNGA3 -3.45 -3.95 1.70E-03 2.90E-02 ENSG00000167528 ZNF641 -0.73 -3.95 1.70E-03 2.90E-02 ENSG00000153208 MERTK 0.95 3.95 1.80E-03 2.90E-02 ENSG00000143164 DCAF6 0.83 3.95 1.80E-03 2.90E-02 ENSG00000026103 FAS -1.2 -3.94 1.80E-03 2.90E-02 ENSG00000207966 MIR29C 1.97 3.94 1.80E-03 2.90E-02 ENSG00000133028 SCO1 -0.72 -3.94 1.80E-03 2.90E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000173141 MRP63 -0.77 -3.94 1.80E-03 2.90E-02 ENSG00000143669 LYST 0.79 3.94 1.80E-03 2.90E-02 ENSG00000168807 SNTB2 1.36 3.94 1.80E-03 2.90E-02 ENSG00000134461 ANKRD16 -1.15 -3.93 1.80E-03 2.90E-02 ENSG00000092330 TINF2 -0.7 -3.93 1.80E-03 2.90E-02 ENSG00000165832 TRUB1 -0.88 -3.93 1.80E-03 2.90E-02 ENSG00000168005 C11orf84 0.78 3.93 1.80E-03 2.90E-02 ENSG00000187097 ENTPD5 -1.1 -3.93 1.80E-03 2.90E-02 ENSG00000155096 AZIN1 -0.64 -3.93 1.80E-03 2.90E-02 ENSG00000174547 MRPL11 -0.91 -3.93 1.80E-03 2.90E-02 ENSG00000184886 PIGW -1.95 -3.92 1.80E-03 2.90E-02 ENSG00000135334 AKIRIN2 1.15 3.92 1.80E-03 2.90E-02 ENSG00000106554 CHCHD3 0.63 3.92 1.80E-03 2.90E-02 ENSG00000168116 KIAA1586 -0.81 -3.92 1.80E-03 2.90E-02 ENSG00000146085 MUT -0.69 -3.92 1.80E-03 2.90E-02 ENSG00000198081 ZFP161 -0.97 -3.92 1.80E-03 2.90E-02 ENSG00000129933 MAU2 0.71 3.92 1.80E-03 2.90E-02 ENSG00000131732 ZCCHC9 -0.92 -3.92 1.80E-03 3.00E-02 ENSG00000197119 SLC25A29 1.25 3.92 1.90E-03 3.00E-02 ENSG00000260054 . 1.09 3.92 1.90E-03 3.00E-02 ENSG00000118420 UBE3D 1.35 3.91 1.90E-03 3.00E-02 ENSG00000164188 RANBP3L 2.04 3.91 1.90E-03 3.00E-02 ENSG00000256223 ZNF10 0.65 3.91 1.90E-03 3.00E-02 ENSG00000137094 DNAJB5 -1.22 -3.91 1.90E-03 3.00E-02 ENSG00000154153 FAM134B -0.82 -3.91 1.90E-03 3.00E-02 ENSG00000137992 DBT -0.89 -3.91 1.90E-03 3.00E-02 ENSG00000022840 RNF10 0.74 3.91 1.90E-03 3.00E-02 ENSG00000241945 PWP2 -1.2 -3.9 1.90E-03 3.00E-02 ENSG00000105993 DNAJB6 0.48 3.9 1.90E-03 3.00E-02 ENSG00000166747 AP1G1 0.53 3.9 1.90E-03 3.00E-02 ENSG00000143393 PI4KB 0.73 3.9 1.90E-03 3.00E-02 ENSG00000231607 DLEU2 -1.56 -3.9 1.90E-03 3.00E-02 ENSG00000185798 WDR53 -1.11 -3.9 1.90E-03 3.00E-02 ENSG00000127423 AUNIP -1.88 -3.89 1.90E-03 3.00E-02 ENSG00000248049 . -0.84 -3.89 1.90E-03 3.10E-02 ENSG00000172869 DMXL1 0.95 3.89 2.00E-03 3.10E-02 ENSG00000187815 ZNF642 -1.24 -3.89 2.00E-03 3.10E-02 ENSG00000213799 ZNF845 -0.95 -3.88 2.00E-03 3.10E-02 ENSG00000106404 CLDN15 1.38 3.88 2.00E-03 3.10E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000053900 ANAPC4 -0.81 -3.88 2.00E-03 3.10E-02 ENSG00000172766 NAA16 0.89 3.88 2.00E-03 3.10E-02 ENSG00000159202 UBE2Z 0.64 3.88 2.00E-03 3.10E-02 ENSG00000116871 MAP7D1 1.09 3.88 2.00E-03 3.10E-02 ENSG00000182405 PGBD4 -1.11 -3.87 2.00E-03 3.10E-02 ENSG00000215417 MIR17HG -1.25 -3.87 2.00E-03 3.10E-02 ENSG00000164484 TMEM200A -1.33 -3.87 2.00E-03 3.10E-02 ENSG00000076984 MAP2K7 1.23 3.87 2.00E-03 3.10E-02 ENSG00000104047 DTWD1 -1.12 -3.87 2.00E-03 3.10E-02 ENSG00000187098 MITF 1.64 3.87 2.00E-03 3.10E-02 ENSG00000120370 GORAB -1.04 -3.87 2.00E-03 3.10E-02 ENSG00000105137 SYDE1 0.99 3.87 2.00E-03 3.10E-02 ENSG00000110344 UBE4A -0.5 -3.87 2.00E-03 3.10E-02 ENSG00000225648 SBDSP1 -0.66 -3.86 2.00E-03 3.10E-02 ENSG00000159267 HLCS -0.69 -3.86 2.10E-03 3.10E-02 ENSG00000197355 UAP1L1 2.09 3.86 2.10E-03 3.10E-02 ENSG00000122257 RBBP6 1.24 3.86 2.10E-03 3.20E-02 ENSG00000167862 ICT1 -0.94 -3.86 2.10E-03 3.20E-02 ENSG00000260400 . 2.26 3.86 2.10E-03 3.20E-02 ENSG00000163249 CCNYL1 0.92 3.85 2.10E-03 3.20E-02 ENSG00000253251 . 1.16 3.85 2.10E-03 3.20E-02 ENSG00000134323 MYCN -2.05 -3.85 2.10E-03 3.20E-02 ENSG00000127955 GNAI1 0.73 3.84 2.10E-03 3.20E-02 ENSG00000171466 ZNF562 -0.95 -3.84 2.10E-03 3.20E-02 ENSG00000147274 RBMX 0.65 3.84 2.10E-03 3.20E-02 ENSG00000169032 MAP2K1 0.7 3.84 2.20E-03 3.30E-02 ENSG00000072364 AFF4 0.58 3.84 2.20E-03 3.30E-02 ENSG00000125633 CCDC93 0.9 3.84 2.20E-03 3.30E-02 ENSG00000172070 SRXN1 -1.59 -3.84 2.20E-03 3.30E-02 ENSG00000253276 CCDC71L -0.83 -3.83 2.20E-03 3.30E-02 ENSG00000100147 CCDC134 1.15 3.83 2.20E-03 3.30E-02 ENSG00000102738 MRPS31 -0.84 -3.83 2.20E-03 3.30E-02 ENSG00000114982 KANSL3 0.81 3.83 2.20E-03 3.30E-02 ENSG00000103550 C16orf88 -0.85 -3.83 2.20E-03 3.30E-02 ENSG00000167113 COQ4 -0.81 -3.83 2.20E-03 3.30E-02 ENSG00000260766 . -1.95 -3.83 2.20E-03 3.30E-02 ENSG00000158850 B4GALT3 0.76 3.83 2.20E-03 3.30E-02 ENSG00000164162 ANAPC10 -0.85 -3.83 2.20E-03 3.30E-02 ENSG00000213281 NRAS -0.55 -3.83 2.20E-03 3.30E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000104880 ARHGEF18 0.88 3.83 2.20E-03 3.30E-02 ENSG00000145358 DDIT4L 2.29 3.83 2.20E-03 3.30E-02 ENSG00000129128 SPCS3 -0.5 -3.82 2.20E-03 3.30E-02 ENSG00000151773 CCDC122 -1.84 -3.82 2.20E-03 3.30E-02 ENSG00000204946 ZNF783 -1.24 -3.82 2.20E-03 3.30E-02 ENSG00000163832 ELP6 -0.71 -3.82 2.20E-03 3.30E-02 ENSG00000110025 SNX15 1.28 3.82 2.20E-03 3.30E-02 ENSG00000177409 SAMD9L -1.75 -3.82 2.20E-03 3.30E-02 ENSG00000162337 LRP5 0.95 3.82 2.20E-03 3.30E-02 ENSG00000164168 TMEM184C -0.57 -3.82 2.20E-03 3.30E-02 ENSG00000112851 ERBB2IP 0.81 3.82 2.20E-03 3.30E-02 ENSG00000181929 PRKAG1 -0.61 -3.81 2.20E-03 3.30E-02 ENSG00000150401 DCUN1D2 0.85 3.81 2.30E-03 3.30E-02 ENSG00000100227 POLDIP3 0.63 3.8 2.30E-03 3.40E-02 ENSG00000181610 MRPS23 -0.69 -3.8 2.30E-03 3.40E-02 ENSG00000135740 SLC9A5 1.62 3.8 2.30E-03 3.40E-02 ENSG00000108423 TUBD1 1.34 3.8 2.30E-03 3.40E-02 ENSG00000169118 CSNK1G1 0.91 3.8 2.30E-03 3.40E-02 ENSG00000137760 ALKBH8 -0.76 -3.8 2.30E-03 3.40E-02 ENSG00000166526 ZNF3 -0.64 -3.8 2.30E-03 3.40E-02 ENSG00000163644 PPM1K 1.27 3.8 2.30E-03 3.40E-02 ENSG00000174485 DENND4A 0.68 3.8 2.30E-03 3.40E-02 ENSG00000207501 . -3.2 -3.79 2.30E-03 3.40E-02 ENSG00000158987 RAPGEF6 1.08 3.79 2.40E-03 3.40E-02 ENSG00000118454 ANKRD13C 0.56 3.79 2.40E-03 3.40E-02 ENSG00000139675 HNRNPA1L2 -0.95 -3.79 2.40E-03 3.40E-02 ENSG00000113597 C5orf44 -0.75 -3.79 2.40E-03 3.40E-02 ENSG00000116350 SRSF4 0.9 3.78 2.40E-03 3.40E-02 ENSG00000162769 FLVCR1 0.75 3.78 2.40E-03 3.40E-02 ENSG00000123908 EIF2C2 0.98 3.78 2.40E-03 3.40E-02 ENSG00000172071 EIF2AK3 1.08 3.78 2.40E-03 3.40E-02 ENSG00000166133 RPUSD2 -0.98 -3.78 2.40E-03 3.50E-02 ENSG00000136045 PWP1 -0.56 -3.78 2.40E-03 3.50E-02 ENSG00000085999 RAD54L 1.48 3.77 2.40E-03 3.50E-02 ENSG00000072415 MPP5 1.12 3.77 2.40E-03 3.50E-02 ENSG00000092094 OSGEP -0.69 -3.77 2.40E-03 3.50E-02 ENSG00000171310 CHST11 -1.48 -3.77 2.40E-03 3.50E-02 ENSG00000197380 DACT3 0.82 3.77 2.40E-03 3.50E-02 ENSG00000136628 EPRS -0.92 -3.77 2.40E-03 3.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000143457 GOLPH3L 1.36 3.77 2.50E-03 3.50E-02 ENSG00000144228 SPOPL 0.9 3.77 2.50E-03 3.50E-02 ENSG00000147416 ATP6V1B2 0.81 3.77 2.50E-03 3.50E-02 ENSG00000240694 PNMA2 -0.73 -3.77 2.50E-03 3.50E-02 ENSG00000114686 MRPL3 -0.76 -3.77 2.50E-03 3.50E-02 ENSG00000114019 AMOTL2 1.25 3.77 2.50E-03 3.50E-02 ENSG00000177125 ZBTB34 0.98 3.76 2.50E-03 3.50E-02 ENSG00000075188 NUP37 -1.07 -3.76 2.50E-03 3.50E-02 ENSG00000119844 AFTPH 0.63 3.76 2.50E-03 3.50E-02 ENSG00000257103 LSM14A 0.61 3.76 2.50E-03 3.50E-02 ENSG00000204054 . -0.88 -3.76 2.50E-03 3.50E-02 ENSG00000215105 TTC3P1 -1.25 -3.76 2.50E-03 3.50E-02 ENSG00000107625 DDX50 -0.84 -3.76 2.50E-03 3.50E-02 ENSG00000061273 HDAC7 0.97 3.76 2.50E-03 3.50E-02 ENSG00000138398 PPIG -0.77 -3.75 2.50E-03 3.60E-02 ENSG00000112640 PPP2R5D 0.67 3.75 2.50E-03 3.60E-02 ENSG00000124145 SDC4 -1.49 -3.75 2.50E-03 3.60E-02 ENSG00000104859 CLASRP 0.99 3.75 2.50E-03 3.60E-02 ENSG00000167088 SNRPD1 -0.88 -3.75 2.50E-03 3.60E-02 ENSG00000100744 GSKIP 0.86 3.75 2.60E-03 3.60E-02 ENSG00000255302 EID1 -0.6 -3.74 2.60E-03 3.60E-02 ENSG00000137693 YAP1 0.87 3.74 2.60E-03 3.60E-02 ENSG00000123983 ACSL3 -0.67 -3.74 2.60E-03 3.60E-02 ENSG00000131435 PDLIM4 -0.89 -3.74 2.60E-03 3.60E-02 ENSG00000204568 MRPS18B -0.68 -3.74 2.60E-03 3.60E-02 ENSG00000136463 TACO1 -0.89 -3.73 2.60E-03 3.70E-02 ENSG00000196072 BLOC1S2 -0.74 -3.73 2.60E-03 3.70E-02 ENSG00000174007 CEP19 1.34 3.73 2.60E-03 3.70E-02 ENSG00000103194 USP10 0.81 3.73 2.60E-03 3.70E-02 ENSG00000115129 TP53I3 -1.09 -3.73 2.60E-03 3.70E-02 ENSG00000197312 DDI2 -0.98 -3.73 2.60E-03 3.70E-02 ENSG00000139832 RAB20 -1.25 -3.73 2.60E-03 3.70E-02 ENSG00000185947 ZNF267 -1.39 -3.72 2.70E-03 3.70E-02 ENSG00000179242 CDH4 1.67 3.72 2.70E-03 3.70E-02 ENSG00000166263 STXBP4 0.86 3.72 2.70E-03 3.70E-02 ENSG00000091879 ANGPT2 1.45 3.72 2.70E-03 3.70E-02 ENSG00000164713 BRI3 0.8 3.72 2.70E-03 3.70E-02 ENSG00000076242 MLH1 -0.62 -3.72 2.70E-03 3.70E-02 ENSG00000103248 MTHFSD -0.7 -3.72 2.70E-03 3.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000133961 NUMB 1.14 3.72 2.70E-03 3.70E-02 ENSG00000124615 MOCS1 -1.31 -3.72 2.70E-03 3.70E-02 ENSG00000152990 GPR125 0.56 3.72 2.70E-03 3.70E-02 ENSG00000204241 . -2.32 -3.72 2.70E-03 3.70E-02 ENSG00000078674 PCM1 0.61 3.72 2.70E-03 3.70E-02 ENSG00000130023 C6orf70 -0.9 -3.72 2.70E-03 3.70E-02 ENSG00000148187 MRRF -0.85 -3.71 2.70E-03 3.70E-02 ENSG00000169189 NSMCE1 -0.75 -3.71 2.70E-03 3.70E-02 ENSG00000249673 NOP14-AS1 -1.18 -3.71 2.70E-03 3.70E-02 ENSG00000100575 TIMM9 -0.99 -3.71 2.70E-03 3.70E-02 ENSG00000117697 NSL1 -0.72 -3.71 2.70E-03 3.70E-02 ENSG00000155636 RBM45 -0.95 -3.71 2.70E-03 3.70E-02 ENSG00000135932 CAB39 0.45 3.71 2.70E-03 3.70E-02 ENSG00000135124 P2RX4 -0.82 -3.71 2.80E-03 3.70E-02 ENSG00000087299 L2HGDH 1.44 3.7 2.80E-03 3.80E-02 ENSG00000179476 C14orf28 -1.77 -3.7 2.80E-03 3.80E-02 ENSG00000146576 C7orf26 0.78 3.7 2.80E-03 3.80E-02 ENSG00000133119 RFC3 -1.11 -3.69 2.80E-03 3.80E-02 ENSG00000147316 MCPH1 -0.85 -3.69 2.80E-03 3.80E-02 ENSG00000180008 SOCS4 -0.67 -3.69 2.80E-03 3.80E-02 ENSG00000196693 ZNF33B -0.99 -3.69 2.80E-03 3.80E-02 ENSG00000162944 RFTN2 1.09 3.69 2.80E-03 3.80E-02 ENSG00000015532 XYLT2 -0.72 -3.69 2.90E-03 3.90E-02 ENSG00000175105 ZNF654 0.91 3.68 2.90E-03 3.90E-02 ENSG00000128272 ATF4 0.75 3.68 2.90E-03 3.90E-02 ENSG00000143434 SEMA6C 1.05 3.68 2.90E-03 3.90E-02 ENSG00000057704 TMCC3 -1.13 -3.67 2.90E-03 3.90E-02 ENSG00000182310 LINC00085 1.5 3.67 2.90E-03 3.90E-02 ENSG00000166436 TRIM66 -1.41 -3.67 2.90E-03 3.90E-02 ENSG00000035681 NSMAF -0.6 -3.67 2.90E-03 3.90E-02 ENSG00000113569 NUP155 -0.59 -3.67 3.00E-03 3.90E-02 ENSG00000103353 UBFD1 0.71 3.67 3.00E-03 4.00E-02 ENSG00000104517 UBR5 0.84 3.67 3.00E-03 4.00E-02 ENSG00000167565 SERTAD3 0.76 3.67 3.00E-03 4.00E-02 ENSG00000004455 AK2 -0.53 -3.67 3.00E-03 4.00E-02 ENSG00000197647 ZNF433 -1.35 -3.66 3.00E-03 4.00E-02 ENSG00000023287 RB1CC1 0.61 3.66 3.00E-03 4.00E-02 ENSG00000117153 KLHL12 -0.69 -3.66 3.00E-03 4.00E-02 ENSG00000183309 ZNF623 -0.74 -3.66 3.00E-03 4.00E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000186654 PRR5 -1.85 -3.66 3.00E-03 4.00E-02 ENSG00000154957 ZNF18 -0.67 -3.66 3.00E-03 4.00E-02 ENSG00000148824 . 1.54 3.66 3.00E-03 4.00E-02 ENSG00000005189 . -0.98 -3.66 3.00E-03 4.00E-02 ENSG00000197265 GTF2E2 0.92 3.66 3.00E-03 4.00E-02 ENSG00000170037 CNTROB 0.66 3.66 3.00E-03 4.00E-02 ENSG00000167766 ZNF83 -0.77 -3.65 3.10E-03 4.00E-02 ENSG00000179041 RRS1 -1.39 -3.65 3.10E-03 4.10E-02 ENSG00000124541 RRP36 -0.63 -3.65 3.10E-03 4.10E-02 ENSG00000143093 STRIP1 0.82 3.65 3.10E-03 4.10E-02 ENSG00000131437 KIF3A 0.66 3.65 3.10E-03 4.10E-02 ENSG00000055917 PUM2 0.93 3.64 3.10E-03 4.10E-02 ENSG00000099810 MTAP -1 -3.64 3.10E-03 4.10E-02 ENSG00000163933 RFT1 -1.03 -3.64 3.10E-03 4.10E-02 ENSG00000040199 PHLPP2 0.69 3.64 3.10E-03 4.10E-02 ENSG00000224531 C6orf228 0.66 3.64 3.10E-03 4.10E-02 ENSG00000165055 METTL2B -0.77 -3.64 3.10E-03 4.10E-02 ENSG00000040275 SPDL1 -0.86 -3.64 3.10E-03 4.10E-02 ENSG00000111237 VPS29 -0.76 -3.63 3.20E-03 4.10E-02 ENSG00000055208 TAB2 0.88 3.63 3.20E-03 4.10E-02 ENSG00000134014 ELP3 -0.64 -3.63 3.20E-03 4.10E-02 ENSG00000176383 B3GNT4 1.26 3.63 3.20E-03 4.10E-02 ENSG00000196872 KIAA1211L -2.02 -3.63 3.20E-03 4.10E-02 ENSG00000256956 . -0.86 -3.63 3.20E-03 4.10E-02 ENSG00000134324 LPIN1 1.27 3.62 3.20E-03 4.20E-02 ENSG00000064687 ABCA7 1.12 3.61 3.30E-03 4.20E-02 ENSG00000120697 ALG5 -0.66 -3.61 3.30E-03 4.20E-02 ENSG00000070018 LRP6 0.98 3.61 3.30E-03 4.20E-02 ENSG00000154743 TSEN2 -0.82 -3.61 3.30E-03 4.20E-02 ENSG00000123091 RNF11 0.5 3.61 3.30E-03 4.20E-02 ENSG00000167840 ZNF232 0.94 3.61 3.30E-03 4.20E-02 ENSG00000171453 POLR1C 0.84 3.61 3.30E-03 4.20E-02 ENSG00000110046 ATG2A 1.15 3.61 3.30E-03 4.20E-02 ENSG00000157764 BRAF 0.63 3.61 3.30E-03 4.30E-02 ENSG00000178295 GEN1 -1.21 -3.61 3.30E-03 4.30E-02 ENSG00000116984 MTR -0.51 -3.61 3.30E-03 4.30E-02 ENSG00000108469 RECQL5 -0.79 -3.61 3.30E-03 4.30E-02 ENSG00000135829 DHX9 0.58 3.61 3.30E-03 4.30E-02 ENSG00000142634 EFHD2 -1.25 -3.6 3.30E-03 4.30E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000235217 TSPY26P -1.05 -3.6 3.40E-03 4.30E-02 ENSG00000128915 NARG2 -0.77 -3.6 3.40E-03 4.30E-02 ENSG00000204120 GIGYF2 0.47 3.6 3.40E-03 4.30E-02 ENSG00000136754 ABI1 0.57 3.6 3.40E-03 4.30E-02 ENSG00000141084 RANBP10 0.94 3.59 3.40E-03 4.30E-02 ENSG00000101216 GMEB2 0.95 3.59 3.40E-03 4.30E-02 ENSG00000006453 BAIAP2L1 1.74 3.59 3.40E-03 4.30E-02 ENSG00000181915 ADO -0.81 -3.59 3.40E-03 4.30E-02 ENSG00000166169 POLL -0.96 -3.59 3.40E-03 4.30E-02 ENSG00000184508 HDDC3 -1.47 -3.59 3.40E-03 4.30E-02 ENSG00000102081 FMR1 0.7 3.59 3.40E-03 4.40E-02 ENSG00000156253 RWDD2B -1.15 -3.59 3.50E-03 4.40E-02 ENSG00000146373 RNF217 1 3.58 3.50E-03 4.40E-02 ENSG00000146910 CNPY1 -1.61 -3.58 3.50E-03 4.40E-02 ENSG00000101974 ATP11C 0.9 3.58 3.50E-03 4.40E-02 ENSG00000206432 TMEM200C 1.78 3.58 3.50E-03 4.40E-02 ENSG00000110171 TRIM3 1.13 3.58 3.50E-03 4.40E-02 ENSG00000167371 PRRT2 1.4 3.58 3.50E-03 4.40E-02 ENSG00000173442 EHBP1L1 1.32 3.58 3.50E-03 4.40E-02 ENSG00000159140 SON 0.62 3.57 3.50E-03 4.40E-02 ENSG00000087087 SRRT 0.87 3.57 3.50E-03 4.40E-02 ENSG00000198382 UVRAG 0.88 3.57 3.50E-03 4.40E-02 ENSG00000235381 . -2.32 -3.57 3.50E-03 4.40E-02 ENSG00000143436 MRPL9 -0.76 -3.57 3.50E-03 4.40E-02 ENSG00000129990 SYT5 -2.18 -3.57 3.60E-03 4.40E-02 ENSG00000041802 LSG1 -0.57 -3.57 3.60E-03 4.50E-02 ENSG00000136861 CDK5RAP2 0.47 3.57 3.60E-03 4.50E-02 ENSG00000170633 RNF34 -0.59 -3.57 3.60E-03 4.50E-02 ENSG00000156374 PCGF6 -0.87 -3.56 3.60E-03 4.50E-02 ENSG00000110768 GTF2H1 0.66 3.56 3.60E-03 4.50E-02 ENSG00000145734 BDP1 0.47 3.56 3.60E-03 4.50E-02 ENSG00000226479 TMEM185B -1.19 -3.56 3.60E-03 4.50E-02 ENSG00000172775 FAM192A -0.56 -3.56 3.60E-03 4.50E-02 ENSG00000124226 RNF114 0.73 3.56 3.70E-03 4.50E-02 ENSG00000037637 FBXO42 0.6 3.56 3.70E-03 4.50E-02 ENSG00000144476 CXCR7 -1.93 -3.56 3.70E-03 4.50E-02 ENSG00000154813 DPH3 -0.56 -3.56 3.70E-03 4.50E-02 ENSG00000198169 ZNF251 0.68 3.55 3.70E-03 4.50E-02 ENSG00000171634 BPTF 0.74 3.55 3.70E-03 4.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000148803 FUOM -1.09 -3.55 3.70E-03 4.50E-02 ENSG00000176261 ZBTB8OS -0.77 -3.55 3.70E-03 4.50E-02 ENSG00000100813 ACIN1 0.6 3.55 3.70E-03 4.50E-02 ENSG00000237984 PTENP1 -1.78 -3.55 3.70E-03 4.50E-02 ENSG00000133612 AGAP3 0.76 3.55 3.70E-03 4.50E-02 ENSG00000204172 AGAP10 -1.68 -3.55 3.70E-03 4.50E-02 ENSG00000229809 ZNF688 -1.53 -3.55 3.70E-03 4.50E-02 ENSG00000189157 FAM47E -1.79 -3.55 3.70E-03 4.50E-02 ENSG00000160688 FLAD1 -0.72 -3.55 3.70E-03 4.50E-02 ENSG00000020577 SAMD4A 1 3.55 3.70E-03 4.50E-02 ENSG00000152620 NADKD1 0.88 3.55 3.70E-03 4.50E-02 ENSG00000157954 WIPI2 0.67 3.55 3.70E-03 4.50E-02 ENSG00000217236 SP9 1.88 3.55 3.70E-03 4.50E-02 ENSG00000113615 SEC24A 1.02 3.55 3.70E-03 4.50E-02 ENSG00000205583 STAG3L1 1.43 3.54 3.70E-03 4.50E-02 ENSG00000165526 RPUSD4 0.62 3.54 3.70E-03 4.50E-02 ENSG00000113716 HMGXB3 0.6 3.54 3.70E-03 4.60E-02 ENSG00000011028 MRC2 0.93 3.54 3.80E-03 4.60E-02 ENSG00000103707 MTFMT -0.81 -3.54 3.80E-03 4.60E-02 ENSG00000115827 DCAF17 -0.79 -3.54 3.80E-03 4.60E-02 ENSG00000126453 BCL2L12 1.8 3.54 3.80E-03 4.60E-02 ENSG00000086712 TXLNG 0.62 3.54 3.80E-03 4.60E-02 ENSG00000187145 MRPS21 -0.71 -3.54 3.80E-03 4.60E-02 ENSG00000186432 KPNA4 0.53 3.54 3.80E-03 4.60E-02 ENSG00000147536 GINS4 -1.31 -3.54 3.80E-03 4.60E-02 ENSG00000165801 ARHGEF40 -0.91 -3.53 3.80E-03 4.60E-02 ENSG00000159592 GPBP1L1 0.72 3.53 3.80E-03 4.60E-02 ENSG00000099381 SETD1A 1.27 3.53 3.80E-03 4.60E-02 ENSG00000119314 PTBP3 -0.63 -3.53 3.80E-03 4.60E-02 ENSG00000173281 PPP1R3B -1.18 -3.53 3.80E-03 4.60E-02 ENSG00000196632 WNK3 0.98 3.53 3.80E-03 4.60E-02 ENSG00000185608 MRPL40 -0.73 -3.53 3.80E-03 4.60E-02 ENSG00000196843 ARID5A 1.98 3.53 3.80E-03 4.60E-02 ENSG00000140987 ZNF434 -0.84 -3.53 3.80E-03 4.60E-02 ENSG00000076108 BAZ2A 1.34 3.53 3.90E-03 4.60E-02 ENSG00000110925 CSRNP2 0.68 3.52 3.90E-03 4.60E-02 ENSG00000124575 HIST1H1D -1.7 -3.52 3.90E-03 4.60E-02 ENSG00000236914 . -2.04 -3.52 3.90E-03 4.70E-02 ENSG00000162377 SELRC1 -1.12 -3.52 3.90E-03 4.70E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000124587 PEX6 0.82 3.52 3.90E-03 4.70E-02 ENSG00000198429 ZNF69 1.42 3.51 4.00E-03 4.70E-02 ENSG00000212978 . -1.23 -3.51 4.00E-03 4.80E-02 ENSG00000104980 TIMM44 0.78 3.51 4.00E-03 4.80E-02 ENSG00000135469 COQ10A 1.09 3.51 4.00E-03 4.80E-02 ENSG00000174579 MSL2 0.83 3.5 4.10E-03 4.80E-02 ENSG00000158796 DEDD 0.84 3.5 4.10E-03 4.80E-02 ENSG00000196074 SYCP2 1.89 3.5 4.10E-03 4.80E-02 ENSG00000101574 METTL4 1.02 3.5 4.10E-03 4.80E-02 ENSG00000121486 TRMT1L -0.99 -3.5 4.10E-03 4.80E-02 ENSG00000188895 MSL1 0.85 3.5 4.10E-03 4.80E-02 ENSG00000151304 SRFBP1 -0.73 -3.49 4.10E-03 4.90E-02 ENSG00000131652 THOC6 0.99 3.49 4.10E-03 4.90E-02 ENSG00000147180 ZNF711 0.6 3.49 4.10E-03 4.90E-02 ENSG00000152689 RASGRP3 1.71 3.49 4.10E-03 4.90E-02 ENSG00000172262 ZNF131 0.52 3.49 4.10E-03 4.90E-02 ENSG00000139684 ESD -0.65 -3.49 4.20E-03 4.90E-02 ENSG00000005339 CREBBP 0.93 3.49 4.20E-03 4.90E-02 ENSG00000082258 CCNT2 -0.53 -3.49 4.20E-03 4.90E-02 ENSG00000108262 GIT1 0.98 3.49 4.20E-03 4.90E-02 ENSG00000168283 BMI1 -0.91 -3.48 4.20E-03 4.90E-02 ENSG00000176407 KCMF1 0.55 3.48 4.20E-03 4.90E-02 ENSG00000157106 SMG1 0.51 3.48 4.20E-03 4.90E-02 ENSG00000117500 TMED5 0.8 3.48 4.20E-03 4.90E-02 ENSG00000214694 ARHGEF33 1.68 3.48 4.20E-03 4.90E-02 ENSG00000160208 RRP1B -0.72 -3.48 4.20E-03 4.90E-02 ENSG00000157827 FMNL2 1.15 3.47 4.30E-03 5.00E-02 ENSG00000157349 DDX19B -0.63 -3.47 4.30E-03 5.00E-02 ENSG00000123066 MED13L 0.88 3.47 4.30E-03 5.00E-02 ENSG00000169016 E2F6 0.78 3.47 4.30E-03 5.00E-02 ENSG00000109083 IFT20 0.72 3.47 4.30E-03 5.00E-02 ENSG00000129474 AJUBA 1.27 3.47 4.30E-03 5.00E-02 ENSG00000106077 ABHD11 -1.47 -3.47 4.30E-03 5.00E-02 ENSG00000163064 EN1 2.38 3.47 4.30E-03 5.00E-02 Ensembl ID, gene symbol, log2 fold change, t statistic, P value and FDR.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 5. Differentially expressed genes for PCID in controls at FDR 5%

Ensembl Gene symbol logFC t P FDR ENSG00000070495 JMJD6 1.31 10.02 2.20E-07 2.00E-03 ENSG00000134294 SLC38A2 2.22 9.78 2.90E-07 2.00E-03 ENSG00000196678 ERI2 -1.98 -9.07 6.80E-07 3.00E-03 ENSG00000068028 RASSF1 1.09 8.86 8.80E-07 3.00E-03 ENSG00000181450 ZNF678 -1.39 -8.71 1.10E-06 3.00E-03 ENSG00000100811 YY1 0.74 8.45 1.50E-06 3.40E-03 ENSG00000185875 THNSL1 -1.52 -8.16 2.20E-06 3.70E-03 ENSG00000141040 ZNF287 -1.39 -8.13 2.20E-06 3.70E-03 ENSG00000196793 ZNF239 -1.52 -8.09 2.40E-06 3.70E-03 ENSG00000197128 ZNF772 -1.04 -7.94 2.90E-06 3.70E-03 ENSG00000182986 ZNF320 -0.94 -7.93 2.90E-06 3.70E-03 ENSG00000170836 PPM1D 1.25 7.72 3.90E-06 4.00E-03 ENSG00000115875 SRSF7 -1.06 -7.71 4.00E-06 4.00E-03 ENSG00000132475 H3F3B -0.85 -7.69 4.10E-06 4.00E-03 ENSG00000198642 KLHL9 -1 -7.53 5.00E-06 4.00E-03 ENSG00000168661 ZNF30 -1.45 -7.53 5.10E-06 4.00E-03 ENSG00000116954 RRAGC 0.96 7.52 5.20E-06 4.00E-03 ENSG00000165355 FBXO33 0.97 7.46 5.60E-06 4.00E-03 ENSG00000120709 FAM53C 1.1 7.46 5.60E-06 4.00E-03 ENSG00000126814 TRMT5 -0.83 -7.44 5.80E-06 4.00E-03 ENSG00000090612 ZNF268 -1.04 -7.3 7.00E-06 4.40E-03 ENSG00000186298 PPP1CC 0.77 7.29 7.10E-06 4.40E-03 ENSG00000188215 DCUN1D3 0.89 7.28 7.20E-06 4.40E-03 ENSG00000196821 C6orf106 0.83 7.14 8.80E-06 4.80E-03 ENSG00000106829 TLE4 1.16 7.1 9.30E-06 4.80E-03 ENSG00000009790 TRAF3IP3 -2.32 -7.09 9.50E-06 4.80E-03 ENSG00000128000 ZNF780B -1.05 -7.06 9.90E-06 4.80E-03 ENSG00000150347 ARID5B 2.08 7.06 1.00E-05 4.80E-03 ENSG00000196409 ZNF658 -1.6 -7.04 1.00E-05 4.80E-03 ENSG00000215251 FASTKD5 0.92 7.01 1.10E-05 4.80E-03 ENSG00000102554 KLF5 2.17 7 1.10E-05 4.80E-03 ENSG00000014123 UFL1 -0.77 -6.98 1.10E-05 4.80E-03 ENSG00000203326 ZNF525 -1.17 -6.94 1.20E-05 5.00E-03 ENSG00000132680 KIAA0907 1.04 6.87 1.30E-05 5.20E-03 ENSG00000105793 GTPBP10 -0.93 -6.87 1.30E-05 5.20E-03 ENSG00000187742 SECISBP2 -0.69 -6.83 1.40E-05 5.30E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000157578 LCA5L -2.1 -6.77 1.50E-05 5.70E-03 ENSG00000177853 ZNF518A -0.78 -6.75 1.60E-05 5.70E-03 ENSG00000181035 SLC25A42 1.22 6.73 1.60E-05 5.70E-03 ENSG00000235109 ZNF323 -1.08 -6.7 1.70E-05 5.80E-03 ENSG00000088451 TGDS -1.68 -6.69 1.70E-05 5.80E-03 ENSG00000145723 GIN1 -1.11 -6.6 1.90E-05 6.40E-03 ENSG00000183161 FANCF -1.04 -6.53 2.20E-05 6.50E-03 ENSG00000141646 SMAD4 0.64 6.52 2.20E-05 6.50E-03 ENSG00000174136 RGMB 0.89 6.49 2.30E-05 6.50E-03 ENSG00000019995 ZRANB1 0.82 6.49 2.30E-05 6.50E-03 ENSG00000175283 DOLK -0.88 -6.47 2.40E-05 6.50E-03 ENSG00000182831 C16orf72 0.74 6.47 2.40E-05 6.50E-03 ENSG00000178700 DHFRL1 -1.11 -6.47 2.40E-05 6.50E-03 ENSG00000183808 RBM12B -0.95 -6.46 2.40E-05 6.50E-03 ENSG00000123136 DDX39A 0.93 6.46 2.40E-05 6.50E-03 ENSG00000197044 ZNF441 -1.52 -6.44 2.50E-05 6.50E-03 ENSG00000153575 TUBGCP5 -0.82 -6.42 2.60E-05 6.50E-03 ENSG00000183864 TOB2 1.25 6.4 2.70E-05 6.50E-03 ENSG00000118900 UBN1 0.93 6.37 2.80E-05 6.50E-03 ENSG00000099622 CIRBP -1.03 -6.37 2.80E-05 6.50E-03 ENSG00000180938 ZNF572 -2.15 -6.37 2.80E-05 6.50E-03 ENSG00000162757 C1orf74 -1.9 -6.37 2.80E-05 6.50E-03 ENSG00000170949 ZNF160 -0.91 -6.36 2.80E-05 6.50E-03 ENSG00000157184 CPT2 -1.09 -6.36 2.80E-05 6.50E-03 ENSG00000089335 ZNF302 -0.88 -6.36 2.80E-05 6.50E-03 ENSG00000154059 IMPACT -0.68 -6.32 3.00E-05 6.70E-03 ENSG00000110721 CHKA 0.91 6.31 3.00E-05 6.70E-03 ENSG00000196670 ZFP62 -1.02 -6.3 3.10E-05 6.70E-03 ENSG00000243927 MRPS6 1.12 6.29 3.10E-05 6.70E-03 ENSG00000162396 PARS2 -1.57 -6.25 3.40E-05 7.00E-03 ENSG00000167522 ANKRD11 1.38 6.25 3.40E-05 7.00E-03 ENSG00000171456 ASXL1 0.72 6.21 3.60E-05 7.30E-03 ENSG00000186496 ZNF396 -1.53 -6.2 3.60E-05 7.30E-03 ENSG00000186812 ZNF397 -0.75 -6.19 3.70E-05 7.30E-03 ENSG00000119787 ATL2 0.77 6.17 3.80E-05 7.50E-03 ENSG00000269343 ZNF587B -1.08 -6.14 4.00E-05 7.60E-03 ENSG00000131127 ZNF141 -1.03 -6.12 4.10E-05 7.70E-03 ENSG00000180257 ZNF816 -1.24 -6.11 4.20E-05 7.70E-03 ENSG00000166478 ZNF143 0.9 6.11 4.20E-05 7.70E-03

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000102409 BEX4 -0.52 -6.09 4.30E-05 7.80E-03 ENSG00000144120 TMEM177 -1.54 -6.06 4.50E-05 8.00E-03 ENSG00000144283 PKP4 0.77 6.05 4.60E-05 8.00E-03 ENSG00000137413 TAF8 0.83 6.05 4.60E-05 8.00E-03 ENSG00000160961 ZNF333 -0.8 -6.04 4.70E-05 8.20E-03 ENSG00000223573 PLAC2 2.47 6.02 4.80E-05 8.30E-03 ENSG00000198346 ZNF813 -0.9 -6.01 4.90E-05 8.40E-03 ENSG00000263244 . -0.85 -5.97 5.20E-05 8.50E-03 ENSG00000155438 MKI67IP -0.94 -5.97 5.20E-05 8.50E-03 ENSG00000170385 SLC30A1 -0.99 -5.97 5.20E-05 8.50E-03 ENSG00000156232 WHAMM 0.93 5.96 5.30E-05 8.50E-03 ENSG00000198517 MAFK 1.75 5.96 5.30E-05 8.50E-03 ENSG00000022976 ZNF839 -0.83 -5.94 5.50E-05 8.60E-03 ENSG00000196345 ZNF167 -1.62 -5.93 5.60E-05 8.70E-03 ENSG00000178567 EPM2AIP1 -0.68 -5.92 5.60E-05 8.70E-03 ENSG00000214654 . -1.54 -5.91 5.80E-05 8.70E-03 ENSG00000005700 IBTK -0.79 -5.91 5.80E-05 8.70E-03 ENSG00000171604 CXXC5 -0.95 -5.9 5.90E-05 8.80E-03 ENSG00000164051 CCDC51 -1.03 -5.87 6.20E-05 9.10E-03 ENSG00000178974 FBXO34 0.72 5.86 6.20E-05 9.10E-03 ENSG00000141642 ELAC1 -1.3 -5.84 6.40E-05 9.30E-03 ENSG00000127980 PEX1 -0.66 -5.83 6.50E-05 9.30E-03 ENSG00000197976 AKAP17A 0.87 5.79 7.00E-05 9.90E-03 ENSG00000244026 FAM86DP -1.27 -5.79 7.00E-05 9.90E-03 ENSG00000137040 RANBP6 -0.72 -5.76 7.30E-05 1.00E-02 ENSG00000175470 PPP2R2D 0.62 5.76 7.40E-05 1.00E-02 ENSG00000106003 LFNG -1.81 -5.74 7.60E-05 1.00E-02 ENSG00000153914 SREK1 0.68 5.74 7.60E-05 1.00E-02 ENSG00000109920 FNBP4 0.76 5.72 7.80E-05 1.00E-02 ENSG00000102908 NFAT5 0.89 5.72 7.80E-05 1.00E-02 ENSG00000135541 AHI1 0.54 5.71 8.00E-05 1.00E-02 ENSG00000186446 ZNF501 -1.55 -5.7 8.10E-05 1.00E-02 ENSG00000181264 TMEM136 -0.9 -5.7 8.10E-05 1.00E-02 ENSG00000109618 SEPSECS -0.9 -5.68 8.40E-05 1.10E-02 ENSG00000251669 FAM86EP -1.98 -5.67 8.50E-05 1.10E-02 ENSG00000143811 PYCR2 -0.83 -5.66 8.60E-05 1.10E-02 ENSG00000144655 CSRNP1 1.27 5.66 8.60E-05 1.10E-02 ENSG00000121440 PDZRN3 0.78 5.65 8.70E-05 1.10E-02 ENSG00000105429 MEGF8 0.87 5.62 9.20E-05 1.10E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000155868 MED7 -0.8 -5.6 9.50E-05 1.10E-02 ENSG00000174796 THAP6 -0.9 -5.57 1.00E-04 1.20E-02 ENSG00000166532 RIMKLB -0.96 -5.56 1.00E-04 1.20E-02 ENSG00000136100 VPS36 -0.64 -5.55 1.00E-04 1.20E-02 ENSG00000134077 THUMPD3 -0.65 -5.54 1.10E-04 1.20E-02 ENSG00000151718 WWC2 1.18 5.54 1.10E-04 1.20E-02 ENSG00000010244 ZNF207 0.46 5.54 1.10E-04 1.20E-02 ENSG00000143367 TUFT1 1.25 5.53 1.10E-04 1.20E-02 ENSG00000125875 TBC1D20 0.68 5.51 1.10E-04 1.30E-02 ENSG00000198890 PRMT6 -1.31 -5.49 1.20E-04 1.30E-02 ENSG00000175215 CTDSP2 0.91 5.48 1.20E-04 1.30E-02 ENSG00000139697 SBNO1 0.51 5.47 1.20E-04 1.30E-02 ENSG00000162775 RBM15 0.57 5.46 1.20E-04 1.30E-02 ENSG00000141098 GFOD2 0.96 5.46 1.20E-04 1.30E-02 ENSG00000267350 . 0.93 5.45 1.20E-04 1.30E-02 ENSG00000136891 TEX10 0.57 5.43 1.30E-04 1.30E-02 ENSG00000198298 ZNF485 -1.41 -5.43 1.30E-04 1.40E-02 ENSG00000170325 PRDM10 0.99 5.42 1.30E-04 1.40E-02 ENSG00000022840 RNF10 0.71 5.41 1.30E-04 1.40E-02 ENSG00000156026 MCU 1 5.41 1.30E-04 1.40E-02 ENSG00000055147 FAM114A2 -0.74 -5.39 1.30E-04 1.40E-02 ENSG00000101935 AMMECR1 0.81 5.39 1.40E-04 1.40E-02 ENSG00000196981 WDR5B -0.98 -5.39 1.40E-04 1.40E-02 ENSG00000198743 SLC5A3 0.94 5.39 1.40E-04 1.40E-02 ENSG00000167566 NCKAP5L 1.33 5.39 1.40E-04 1.40E-02 ENSG00000011114 BTBD7 0.47 5.38 1.40E-04 1.40E-02 ENSG00000152219 ARL14EP -0.71 -5.38 1.40E-04 1.40E-02 ENSG00000174233 ADCY6 0.68 5.36 1.40E-04 1.40E-02 ENSG00000166704 ZNF606 -0.78 -5.35 1.40E-04 1.40E-02 ENSG00000121903 ZSCAN20 -0.82 -5.35 1.50E-04 1.40E-02 ENSG00000123352 SPATS2 1 5.34 1.50E-04 1.40E-02 ENSG00000176994 SMCR8 0.91 5.33 1.50E-04 1.40E-02 ENSG00000117289 TXNIP -1.49 -5.33 1.50E-04 1.40E-02 ENSG00000123415 SMUG1 -0.7 -5.33 1.50E-04 1.40E-02 ENSG00000060339 CCAR1 0.61 5.32 1.50E-04 1.40E-02 ENSG00000172175 MALT1 0.85 5.31 1.50E-04 1.40E-02 ENSG00000221843 C2orf16 -1.39 -5.31 1.60E-04 1.40E-02 ENSG00000108264 TADA2A -0.92 -5.29 1.60E-04 1.50E-02 ENSG00000068097 HEATR6 -0.7 -5.29 1.60E-04 1.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000110075 PPP6R3 0.52 5.28 1.60E-04 1.50E-02 ENSG00000174599 TRAM1L1 -1.22 -5.28 1.60E-04 1.50E-02 ENSG00000165006 UBAP1 0.73 5.28 1.60E-04 1.50E-02 ENSG00000164967 RPP25L -1.07 -5.27 1.70E-04 1.50E-02 ENSG00000160633 SAFB 0.8 5.25 1.70E-04 1.50E-02 ENSG00000197841 ZNF181 -0.8 -5.24 1.70E-04 1.50E-02 ENSG00000170854 MINA -0.81 -5.24 1.70E-04 1.50E-02 ENSG00000154803 FLCN 0.74 5.24 1.80E-04 1.50E-02 ENSG00000101191 DIDO1 0.55 5.23 1.80E-04 1.50E-02 ENSG00000011243 AKAP8L 0.88 5.21 1.80E-04 1.60E-02 ENSG00000187187 ZNF546 -0.9 -5.2 1.90E-04 1.60E-02 ENSG00000065183 WDR3 -0.59 -5.18 1.90E-04 1.60E-02 ENSG00000173275 ZNF449 -0.87 -5.17 2.00E-04 1.60E-02 ENSG00000158615 PPP1R15B 0.87 5.16 2.00E-04 1.70E-02 ENSG00000108666 C17orf75 -0.86 -5.16 2.00E-04 1.70E-02 ENSG00000146433 TMEM181 -0.68 -5.16 2.00E-04 1.70E-02 ENSG00000198924 DCLRE1A -0.93 -5.15 2.00E-04 1.70E-02 ENSG00000180198 RCC1 0.73 5.14 2.10E-04 1.70E-02 ENSG00000165626 BEND7 1.01 5.14 2.10E-04 1.70E-02 ENSG00000073792 IGF2BP2 0.85 5.14 2.10E-04 1.70E-02 ENSG00000132388 UBE2G1 0.53 5.14 2.10E-04 1.70E-02 ENSG00000183624 C3orf37 0.72 5.13 2.10E-04 1.70E-02 ENSG00000054267 ARID4B 0.56 5.13 2.10E-04 1.70E-02 ENSG00000125266 EFNB2 1 5.12 2.10E-04 1.70E-02 ENSG00000254004 ZNF260 -0.6 -5.12 2.10E-04 1.70E-02 ENSG00000128607 KLHDC10 0.57 5.11 2.20E-04 1.70E-02 ENSG00000049769 PPP1R3F 0.67 5.1 2.20E-04 1.70E-02 ENSG00000179941 BBS10 -0.88 -5.09 2.20E-04 1.70E-02 ENSG00000090263 MRPS33 -0.7 -5.08 2.30E-04 1.70E-02 ENSG00000127993 RBM48 0.69 5.08 2.30E-04 1.70E-02 ENSG00000183340 JRKL -0.83 -5.08 2.30E-04 1.70E-02 ENSG00000103942 HOMER2 -0.86 -5.06 2.40E-04 1.80E-02 ENSG00000111358 GTF2H3 -0.71 -5.06 2.40E-04 1.80E-02 ENSG00000162927 PUS10 -1.42 -5.06 2.40E-04 1.80E-02 ENSG00000189050 RNFT1 -1.08 -5.05 2.40E-04 1.80E-02 ENSG00000119927 GPAM -0.58 -5.05 2.40E-04 1.80E-02 ENSG00000160221 C21orf33 -0.71 -5.04 2.40E-04 1.80E-02 ENSG00000127125 PPCS -0.71 -5.04 2.40E-04 1.80E-02 ENSG00000253738 . -0.75 -5.04 2.50E-04 1.80E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000132003 ZSWIM4 1.23 5.03 2.50E-04 1.80E-02 ENSG00000177383 MAGEF1 -0.55 -5.03 2.50E-04 1.80E-02 ENSG00000144792 ZNF660 -0.87 -5.02 2.60E-04 1.80E-02 ENSG00000141458 NPC1 0.79 5 2.60E-04 1.90E-02 ENSG00000169515 CCDC8 -0.99 -5 2.60E-04 1.90E-02 ENSG00000106305 AIMP2 -0.82 -5 2.60E-04 1.90E-02 ENSG00000125846 ZNF133 -0.76 -4.99 2.70E-04 1.90E-02 ENSG00000184517 ZFP1 -0.68 -4.98 2.70E-04 1.90E-02 ENSG00000008405 CRY1 0.68 4.98 2.70E-04 1.90E-02 ENSG00000173120 KDM2A 0.74 4.98 2.70E-04 1.90E-02 ENSG00000134186 PRPF38B 0.8 4.98 2.70E-04 1.90E-02 ENSG00000257315 ZBED6 0.98 4.98 2.70E-04 1.90E-02 ENSG00000143514 TP53BP2 0.55 4.97 2.80E-04 1.90E-02 ENSG00000018510 AGPS -0.45 -4.97 2.80E-04 1.90E-02 ENSG00000149313 AASDHPPT -0.53 -4.96 2.80E-04 1.90E-02 ENSG00000198855 FICD -1.03 -4.96 2.80E-04 1.90E-02 ENSG00000176095 IP6K1 0.73 4.96 2.90E-04 1.90E-02 ENSG00000010818 HIVEP2 1.02 4.95 2.90E-04 1.90E-02 ENSG00000105171 POP4 -0.77 -4.95 2.90E-04 1.90E-02 ENSG00000164815 ORC5 -0.71 -4.94 2.90E-04 1.90E-02 ENSG00000243701 . -0.71 -4.94 2.90E-04 1.90E-02 ENSG00000108861 DUSP3 0.63 4.93 3.00E-04 1.90E-02 ENSG00000174206 C12orf66 -0.95 -4.93 3.00E-04 1.90E-02 ENSG00000103404 USP31 0.76 4.93 3.00E-04 1.90E-02 ENSG00000065559 MAP2K4 0.85 4.92 3.00E-04 1.90E-02 ENSG00000149182 ARFGAP2 -0.68 -4.92 3.00E-04 1.90E-02 ENSG00000110172 CHORDC1 0.64 4.92 3.00E-04 1.90E-02 ENSG00000156860 FBRS 0.78 4.91 3.10E-04 2.00E-02 ENSG00000119599 DCAF4 -1.09 -4.9 3.10E-04 2.00E-02 ENSG00000097096 SYDE2 0.74 4.9 3.10E-04 2.00E-02 ENSG00000108039 XPNPEP1 -0.57 -4.88 3.20E-04 2.00E-02 ENSG00000065491 TBC1D22B 0.92 4.88 3.30E-04 2.00E-02 ENSG00000197063 MAFG 1.15 4.87 3.30E-04 2.00E-02 ENSG00000128285 MCHR1 -1.55 -4.87 3.30E-04 2.00E-02 ENSG00000108669 CYTH1 0.68 4.87 3.30E-04 2.00E-02 ENSG00000114126 TFDP2 0.53 4.87 3.30E-04 2.00E-02 ENSG00000104320 NBN -0.87 -4.87 3.30E-04 2.00E-02 ENSG00000171469 ZNF561 -0.63 -4.86 3.40E-04 2.00E-02 ENSG00000166192 SENP8 -1.3 -4.85 3.40E-04 2.00E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000136866 ZFP37 -0.72 -4.85 3.40E-04 2.00E-02 ENSG00000169047 IRS1 1.06 4.85 3.40E-04 2.00E-02 ENSG00000102743 SLC25A15 -0.94 -4.85 3.40E-04 2.00E-02 ENSG00000104381 GDAP1 -0.63 -4.85 3.40E-04 2.00E-02 ENSG00000123268 ATF1 0.68 4.85 3.40E-04 2.00E-02 ENSG00000006530 AGK -0.55 -4.85 3.40E-04 2.00E-02 ENSG00000148444 COMMD3 -0.84 -4.84 3.50E-04 2.00E-02 ENSG00000101901 ALG13 -0.58 -4.84 3.50E-04 2.00E-02 ENSG00000090989 EXOC1 -0.5 -4.83 3.60E-04 2.10E-02 ENSG00000138311 ZNF365 -0.9 -4.8 3.70E-04 2.10E-02 ENSG00000188725 C5orf43 -0.61 -4.8 3.70E-04 2.10E-02 ENSG00000116560 SFPQ 0.5 4.8 3.70E-04 2.10E-02 ENSG00000155100 OTUD6B -0.76 -4.8 3.80E-04 2.10E-02 ENSG00000151461 UPF2 0.61 4.79 3.80E-04 2.10E-02 ENSG00000198185 ZNF334 -0.84 -4.79 3.80E-04 2.20E-02 ENSG00000108256 NUFIP2 0.61 4.79 3.80E-04 2.20E-02 ENSG00000166233 ARIH1 0.43 4.78 3.90E-04 2.20E-02 ENSG00000082213 C5orf22 -0.69 -4.77 3.90E-04 2.20E-02 ENSG00000110851 PRDM4 0.45 4.77 4.00E-04 2.20E-02 ENSG00000158301 GPRASP2 -0.99 -4.76 4.00E-04 2.20E-02 ENSG00000157212 PAXIP1 0.72 4.76 4.00E-04 2.20E-02 ENSG00000005801 ZNF195 -0.71 -4.75 4.10E-04 2.20E-02 ENSG00000180964 TCEAL8 -0.75 -4.75 4.10E-04 2.20E-02 ENSG00000202515 VTRNA1-3 -1.11 -4.74 4.10E-04 2.20E-02 ENSG00000032444 PNPLA6 1 4.74 4.20E-04 2.20E-02 ENSG00000160194 NDUFV3 -0.6 -4.74 4.20E-04 2.20E-02 ENSG00000145675 PIK3R1 -0.84 -4.74 4.20E-04 2.20E-02 ENSG00000138613 APH1B -0.9 -4.74 4.20E-04 2.20E-02 ENSG00000197557 TTC30A -1.3 -4.72 4.30E-04 2.30E-02 ENSG00000138621 PPCDC -1.22 -4.72 4.30E-04 2.30E-02 ENSG00000170832 USP32 0.58 4.71 4.30E-04 2.30E-02 ENSG00000196214 ZNF766 -0.96 -4.71 4.40E-04 2.30E-02 ENSG00000253190 . -1.06 -4.7 4.40E-04 2.30E-02 ENSG00000133065 SLC41A1 0.97 4.7 4.40E-04 2.30E-02 ENSG00000260966 . -0.8 -4.7 4.50E-04 2.30E-02 ENSG00000185838 GNB1L 1.33 4.7 4.50E-04 2.30E-02 ENSG00000153561 RMND5A 0.54 4.69 4.60E-04 2.40E-02 ENSG00000133639 BTG1 1.05 4.69 4.60E-04 2.40E-02 ENSG00000123908 EIF2C2 0.85 4.68 4.60E-04 2.40E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000162104 ADCY9 1.05 4.04 1.50E-03 4.10E-02 ENSG00000111481 COPZ1 -0.37 -4.03 1.50E-03 4.10E-02 ENSG00000122299 ZC3H7A 0.51 4.03 1.50E-03 4.10E-02 ENSG00000096717 SIRT1 0.89 4.03 1.50E-03 4.10E-02 ENSG00000111707 SUDS3 0.47 4.03 1.50E-03 4.10E-02 ENSG00000160767 FAM189B 1.11 4.03 1.50E-03 4.10E-02 ENSG00000135953 MFSD9 0.69 4.03 1.50E-03 4.10E-02 ENSG00000153767 GTF2E1 -0.65 -4.01 1.60E-03 4.20E-02 ENSG00000108826 MRPL27 -0.44 -4.01 1.60E-03 4.20E-02 ENSG00000132773 TOE1 -0.96 -4.01 1.60E-03 4.20E-02 ENSG00000057294 PKP2 1.27 4.01 1.60E-03 4.20E-02 ENSG00000229043 . -1.33 -4 1.60E-03 4.30E-02 ENSG00000166398 KIAA0355 0.52 4 1.60E-03 4.30E-02 ENSG00000123358 NR4A1 1.67 3.99 1.60E-03 4.30E-02 ENSG00000125650 PSPN 0.82 3.99 1.60E-03 4.30E-02 ENSG00000155636 RBM45 -0.71 -3.99 1.60E-03 4.30E-02 ENSG00000126804 ZBTB1 0.42 3.99 1.60E-03 4.30E-02 ENSG00000133961 NUMB 0.85 3.99 1.60E-03 4.30E-02 ENSG00000180626 ZNF594 -0.8 -3.99 1.60E-03 4.30E-02 ENSG00000130349 C6orf203 -0.73 -3.99 1.60E-03 4.30E-02 ENSG00000113643 RARS -0.48 -3.99 1.60E-03 4.30E-02 ENSG00000198081 ZFP161 -0.69 -3.98 1.60E-03 4.30E-02 ENSG00000035403 VCL 0.66 3.98 1.60E-03 4.30E-02 ENSG00000170776 AKAP13 0.42 3.98 1.70E-03 4.40E-02 ENSG00000129128 SPCS3 -0.36 -3.97 1.70E-03 4.40E-02 ENSG00000137693 YAP1 0.64 3.97 1.70E-03 4.40E-02 ENSG00000185608 MRPL40 -0.58 -3.97 1.70E-03 4.40E-02 ENSG00000137547 MRPL15 -0.7 -3.97 1.70E-03 4.40E-02 ENSG00000159140 SON 0.48 3.97 1.70E-03 4.40E-02 ENSG00000124479 NDP -1.31 -3.96 1.70E-03 4.40E-02 ENSG00000164631 ZNF12 -0.46 -3.96 1.70E-03 4.40E-02 ENSG00000164941 INTS8 0.65 3.96 1.70E-03 4.40E-02 ENSG00000160172 FAM86C2P -1.47 -3.96 1.70E-03 4.40E-02 ENSG00000114982 KANSL3 0.59 3.96 1.70E-03 4.40E-02 ENSG00000132613 MTSS1L 0.68 3.96 1.70E-03 4.40E-02 ENSG00000236255 . 1.15 3.96 1.70E-03 4.40E-02 ENSG00000155252 PI4K2A 0.71 3.95 1.70E-03 4.50E-02 ENSG00000168807 SNTB2 0.95 3.95 1.70E-03 4.50E-02 ENSG00000104960 PTOV1 0.59 3.95 1.70E-03 4.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000129474 AJUBA 1 3.95 1.80E-03 4.50E-02 ENSG00000132481 TRIM47 -1.37 -3.94 1.80E-03 4.50E-02 ENSG00000120137 PANK3 0.49 3.94 1.80E-03 4.50E-02 ENSG00000204634 TBC1D8 -0.74 -3.93 1.80E-03 4.60E-02 ENSG00000151500 THYN1 -0.65 -3.93 1.80E-03 4.60E-02 ENSG00000153922 CHD1 0.48 3.93 1.80E-03 4.60E-02 ENSG00000204130 RUFY2 -0.36 -3.93 1.80E-03 4.60E-02 ENSG00000148835 TAF5 0.82 3.92 1.80E-03 4.60E-02 ENSG00000074181 NOTCH3 0.72 3.92 1.80E-03 4.60E-02 ENSG00000001084 GCLC 0.54 3.92 1.80E-03 4.60E-02 ENSG00000135775 COG2 -0.51 -3.92 1.90E-03 4.70E-02 ENSG00000108306 FBXL20 0.58 3.91 1.90E-03 4.70E-02 ENSG00000167186 COQ7 -0.47 -3.91 1.90E-03 4.70E-02 ENSG00000163728 TTC14 -0.54 -3.91 1.90E-03 4.70E-02 ENSG00000221883 ARIH2OS -1.18 -3.91 1.90E-03 4.70E-02 ENSG00000121073 SLC35B1 -0.43 -3.91 1.90E-03 4.70E-02 ENSG00000108733 PEX12 -0.88 -3.91 1.90E-03 4.70E-02 ENSG00000058063 ATP11B 0.42 3.9 1.90E-03 4.70E-02 ENSG00000110046 ATG2A 0.86 3.9 1.90E-03 4.70E-02 ENSG00000197062 . -0.49 -3.9 1.90E-03 4.70E-02 ENSG00000104691 UBXN8 -0.72 -3.9 1.90E-03 4.70E-02 ENSG00000100226 GTPBP1 0.61 3.89 1.90E-03 4.80E-02 ENSG00000196693 ZNF33B -0.73 -3.89 1.90E-03 4.80E-02 ENSG00000165416 SUGT1 0.38 3.89 1.90E-03 4.80E-02 ENSG00000138035 PNPT1 -0.52 -3.89 2.00E-03 4.80E-02 ENSG00000204623 ZNRD1-AS1 -0.87 -3.89 2.00E-03 4.80E-02 ENSG00000116337 AMPD2 0.52 3.89 2.00E-03 4.80E-02 ENSG00000174791 RIN1 -1.44 -3.88 2.00E-03 4.80E-02 ENSG00000108510 MED13 0.59 3.88 2.00E-03 4.80E-02 ENSG00000164713 BRI3 0.58 3.88 2.00E-03 4.80E-02 ENSG00000144827 ABHD10 -0.48 -3.88 2.00E-03 4.80E-02 ENSG00000103356 EARS2 -0.5 -3.88 2.00E-03 4.80E-02 ENSG00000257511 . 1.48 3.88 2.00E-03 4.80E-02 ENSG00000151611 MMAA -0.93 -3.87 2.00E-03 4.90E-02 ENSG00000179632 MAF1 0.49 3.87 2.00E-03 4.90E-02 ENSG00000196437 ZNF569 -0.63 -3.87 2.00E-03 4.90E-02 ENSG00000165219 GAPVD1 0.45 3.87 2.00E-03 4.90E-02 ENSG00000005339 CREBBP 0.72 3.87 2.00E-03 4.90E-02 ENSG00000162290 DCP1A 0.69 3.87 2.00E-03 4.90E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000143294 PRCC 0.88 3.86 2.00E-03 4.90E-02 ENSG00000213888 . -1.19 -3.86 2.10E-03 4.90E-02 ENSG00000139083 ETV6 1.18 3.86 2.10E-03 4.90E-02 ENSG00000135540 NHSL1 1 3.86 2.10E-03 4.90E-02 ENSG00000135334 AKIRIN2 0.79 3.86 2.10E-03 4.90E-02 ENSG00000146085 MUT -0.47 -3.86 2.10E-03 4.90E-02 ENSG00000129055 ANAPC13 -0.43 -3.86 2.10E-03 4.90E-02 ENSG00000141084 RANBP10 0.7 3.85 2.10E-03 4.90E-02 ENSG00000077454 LRCH4 0.89 3.85 2.10E-03 4.90E-02 ENSG00000117305 HMGCL -0.73 -3.85 2.10E-03 4.90E-02 ENSG00000121879 PIK3CA 0.44 3.84 2.10E-03 5.00E-02 ENSG00000152104 PTPN14 0.89 3.84 2.10E-03 5.00E-02 Ensembl ID, gene symbol, log2 fold change, t statistic, P value and FDR.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 6. Differentially expressed genes for PCID in schizophrenia at FDR 5%

Ensembl Gene symbol logFC t P FDR ENSG00000068028 RASSF1 1.19 9.57 3.70E-07 5.20E-03 ENSG00000165355 FBXO33 1.14 8.63 1.20E-06 7.20E-03 ENSG00000134294 SLC38A2 1.93 8.4 1.60E-06 7.20E-03 ENSG00000070495 JMJD6 1.08 8.19 2.10E-06 7.20E-03 ENSG00000132680 KIAA0907 1.16 7.58 4.70E-06 1.10E-02 ENSG00000244026 FAM86DP -1.66 -7.41 6.00E-06 1.10E-02 ENSG00000100811 YY1 0.65 7.36 6.50E-06 1.10E-02 ENSG00000132475 H3F3B -0.82 -7.35 6.60E-06 1.10E-02 ENSG00000188215 DCUN1D3 0.9 7.24 7.60E-06 1.10E-02 ENSG00000123268 ATF1 1.02 7.2 8.10E-06 1.10E-02 ENSG00000141098 GFOD2 1.27 7.16 8.60E-06 1.10E-02 ENSG00000186298 PPP1CC 0.74 6.96 1.10E-05 1.30E-02 ENSG00000263244 . -0.99 -6.86 1.30E-05 1.40E-02 ENSG00000115875 SRSF7 -0.92 -6.64 1.80E-05 1.70E-02 ENSG00000183340 JRKL -1.1 -6.63 1.90E-05 1.70E-02 ENSG00000198642 KLHL9 -0.88 -6.6 2.00E-05 1.70E-02 ENSG00000166478 ZNF143 0.98 6.54 2.10E-05 1.70E-02 ENSG00000013441 CLK1 0.9 6.42 2.60E-05 2.00E-02 ENSG00000185875 THNSL1 -1.17 -6.2 3.60E-05 2.50E-02 ENSG00000137413 TAF8 0.86 6.17 3.80E-05 2.50E-02 ENSG00000116954 RRAGC 0.8 6.16 3.80E-05 2.50E-02 ENSG00000253190 . -1.41 -6.12 4.10E-05 2.60E-02 ENSG00000214654 . -1.61 -6.08 4.40E-05 2.60E-02 ENSG00000178974 FBXO34 0.75 6.04 4.60E-05 2.70E-02 ENSG00000196821 C6orf106 0.71 6.02 4.80E-05 2.70E-02 ENSG00000185838 GNB1L 1.7 5.94 5.50E-05 2.90E-02 ENSG00000144792 ZNF660 -1.04 -5.91 5.80E-05 2.90E-02 ENSG00000269343 ZNF587B -1.06 -5.91 5.80E-05 2.90E-02 ENSG00000126814 TRMT5 -0.67 -5.89 6.00E-05 2.90E-02 ENSG00000197128 ZNF772 -0.78 -5.87 6.20E-05 2.90E-02 ENSG00000049769 PPP1R3F 0.78 5.84 6.40E-05 2.90E-02 ENSG00000131127 ZNF141 -0.99 -5.79 7.00E-05 3.00E-02 ENSG00000180938 ZNF572 -1.97 -5.75 7.40E-05 3.10E-02 ENSG00000158483 FAM86C1 -2.03 -5.72 7.80E-05 3.20E-02 ENSG00000223573 PLAC2 2.35 5.67 8.50E-05 3.40E-02 ENSG00000148835 TAF5 1.2 5.64 8.90E-05 3.50E-02

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENSG00000196678 ERI2 -1.24 -5.59 9.60E-05 3.60E-02 ENSG00000183808 RBM12B -0.83 -5.54 1.00E-04 3.80E-02 ENSG00000164603 C7orf60 0.9 5.52 1.10E-04 3.80E-02 ENSG00000174206 C12orf66 -1.08 -5.51 1.10E-04 3.80E-02 ENSG00000170836 PPM1D 0.9 5.49 1.10E-04 3.90E-02 ENSG00000153914 SREK1 0.65 5.43 1.30E-04 4.20E-02 ENSG00000110721 CHKA 0.79 5.4 1.30E-04 4.30E-02 ENSG00000215251 FASTKD5 0.72 5.37 1.40E-04 4.40E-02 ENSG00000155868 MED7 -0.77 -5.32 1.50E-04 4.60E-02 ENSG00000244462 RBM12 -0.69 -5.3 1.60E-04 4.60E-02 ENSG00000235109 ZNF323 -0.86 -5.28 1.60E-04 4.60E-02 ENSG00000119787 ATL2 0.67 5.27 1.60E-04 4.60E-02 ENSG00000136100 VPS36 -0.62 -5.26 1.70E-04 4.60E-02 ENSG00000160172 FAM86C2P -1.97 -5.24 1.70E-04 4.60E-02 ENSG00000122783 C7orf49 -0.65 -5.24 1.70E-04 4.60E-02 ENSG00000108264 TADA2A -0.93 -5.24 1.70E-04 4.60E-02 ENSG00000087206 UIMC1 0.75 5.23 1.80E-04 4.70E-02 ENSG00000262944 . -0.95 -5.2 1.90E-04 4.80E-02 ENSG00000181450 ZNF678 -0.84 -5.19 1.90E-04 4.80E-02 ENSG00000185567 AHNAK2 -1.2 -5.17 2.00E-04 4.80E-02 ENSG00000110172 CHORDC1 0.68 5.17 2.00E-04 4.80E-02 ENSG00000205808 PPAPDC2 -1.17 -5.14 2.10E-04 5.00E-02 ENSG00000135679 MDM2 -0.68 -5.13 2.10E-04 5.00E-02 Ensembl ID, gene symbol, log2 fold change, t statistic, P value and FDR.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 7. Summary of coexpression modules associated with diagnosis and PCID

Mo Trait association (FDR <0.05) Top Top enriched Top 5 hub dul Diagno PCI PCID in PCID enriched hypothesis driven genes (based e sis D Control in SCZ molecula

col (SCZ (KCl (KCl vs (KCl vs r categories on module or vs vs PBS) PBS) pathways membership) Contro PBS)

l)

Bla go:BP|reg Sugino/Winden:blue_I AASDH, ck ulation of nterneurons_Hippocam LYPLAL1, transcripti

on, DNA- pus(Sst+)/Cingulate(Pv ZBTB34,

templated alb+); PACRGL, ; HumanMeta:turquoise_ MEA1 genefamil

y:MITOA M14_Nucleus;

F|Mitocho Sugino/Winden:orange ndrial _Interneurons_Cingulat respirator

y chain e(Cck+)/Somatosensor

complex y(Cck+)/LGN assembly

factors;

go:CC|D

NA-

directed

RNA

polymeras

e II,

holoenzy

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 me

Blu go:CC|int Sugino/Winden:midnightblue_ FRMPD2, DCDC5,

e egral pyramidalNeurons_Layers5&6 MPDZ, IL5RA,

componen /basolateralAmygdala; ENSG00000250303

t of Golgi Zhang:Astrocyte;

membran HumanMeta:brown_M3_Astro

e; cytes

genefamil

y:ST3G|S

ialyltransf

erases;

reactome:

Elastic

fibre

formation

Bro  go:BP|neu FMRP targets:Darnell; MTSS1, wn ron Zhang:Neuron; ABA:Neuron SEZ6L2, projection

developm HCN3,

ent; DNAL4, reactome: DNAJC6 Glutamate

Neurotran

smitter

Release

Cycle;

reactome:

Interactio

n between

L1 and

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Downloaded From: https://jamanetwork.com/ on 10/01/2021

Cy go:BP|DN ABA:Oligodendrocyte; HAGH, KIN,

an A Sugino/Winden:black_pyramid REPIN1, ZADH2,

replicatio alNeurons_Hippocampus/Amy ZNF576

n; gdala;

go:CC|nu HumanChimp:black_WhiteMat

clear ter

chromoso

me,

telomeric

region;

go:BP|pro

tein

heteroolig

omerizati

on

Gr    genefamil CTX:yellow_M18; DYRK1B, een y:ZNF|Zi HumanMeta:cyan_M4_Mitoch TMEM128, nc ondria;

fingers, MouseMeta:magenta_M8_Mic MRPS23,

C2H2- roglia(Type2) GTF3C3, type; FAM117A go:BP|reg

ulation of

transcripti

on, DNA-

templated

;

go:MF|his

tone

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 acetyl-

binding

Gr reactome: MO:Mitochondria_Foster; DPF2, DCAF7,

een Respirator MitochondrialType:Synaptic; MYL6B, CPSF7,

yell y electron Neuronal proteome:PSD RPL3

ow transport,

ATP

synthesis

by

chemiosm

otic

coupling,

and heat

productio

n by

uncouplin

g

.;

reactome:

The citric

acid

(TCA)

cycle and

respirator

y electron

transport;

genefamil

y:MRPS|

Mitochon

drial

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ribosomal

proteins /

small

subunits

Ma go:MF|pe HumanMeta:cyan_M4_Mitoch SBF1, RHOT2,

gen ptide ondria; UBE2M, DRAP1,

ta binding; CTX:pink_M14_Glutamatergic FBXW5

go:BP|end SynapticFunction;

osome MouseMeta:cyan_M4_Mitoch

organizati ondria

on;

go:BP|pos

itive

regulation

of protein

catabolic

process

Mi go:MF|Rh CTX:green_M10_Glutamatergi PITPNA, VPS53,

dni o GTPase cSynapticFunction; MRPL39, STMN1,

ght binding; GWAS:PGC2 SCZ; RAI1

blu go:MF|hel Sugino/Winden:brown_pyrami

e icase dalNeurons_Layer5/basolateral

activity; Amygdala

reactome:

Netrin-1

signaling

Pin reactome: HumanMeta:red_M11_Neuron NUP153, METTL9,

k Antiviral ; CTX:blue_M16_Neuron; GPR107, EXOC4,

mechanis MO:Proteasome_Foster MKL2

m by

IFN-

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 stimulated

genes;

reactome:

ISG15

antiviral

mechanis

m;

reactome:

Host

Interactio

ns of HIV

factors

Pur reactome: HumanMeta:green_M5_Mitoc DCP2, FAM82A1,

ple Recruitme hondria; ZNF853, C20orf72,

nt of HumanMeta:greenyellow_M6_ WBP4

NuMA to GlutatmatergicSynapse;

mitotic Torkamani:Module_7

centrosom

es;

reactome:

Kinesins;

go:MF|nu

clear

hormone

receptor

binding

Re go:BP|cili Zissel:Ependymal; CCDC164,

d um ABA:Choroid_plexus; LRP2BP, ENO4,

assembly; ABA:Neuron FAM81B, C1orf192

go:CC|mo

tile

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 cilium;

go:BP|reg

ulation of

insulin

secretion

Sal go:CC|me Sugino/Winden:blue_Interneur ABHD3, C10orf88,

mo diator ons_Hippocampus(Sst+)/Cingu TBC1D23,

n complex; late(Pvalb+); SLC17A5, GTF2B

reactome: HumanChimp:green_CortexAn

Transcript dCerebellum; De novos: SCZ

ional NS

regulation

of white

adipocyte

differentia

tion;

go:BP|pro

tein O-

linked

glycosylat

ion

Ta reactome: Sugino/Winden:brown_pyrami TXN, UTP23,

n Fanconi dalNeurons_Layer5/basolateral C6orf48,

Anemia Amygdala; ENSG00000252139,

pathway; HumanMeta:red_M11_Neuron COMMD2

go:BP|res ;

ponse to HumanMeta:lightcyan_M7_un

UV; knownHumanSpecific

reactome:

DNA

Repair

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 Tu  reactome: HumanMeta:salmon_M12_Rib RTN1, HS3ST3A1,

rqu Formation osome; ROBO2, ADRA1A,

oise of a pool CTX:midnightblue_M2_Ribos MYH2

of free ome;

40S MouseMeta:green_M5_Mitoch

subunits; ondria

reactome:

3' -UTR-

mediated

translatio

nal

regulation

;

reactome:

L13a-

mediated

translatio

nal

silencing

of

Cerulopla

smin

expressio

n

Yel   go:BP|tR HumanMeta:turquoise_M14_N PPP2R2D,

low NA ucleus; CTX:black_M11; THNSL1, PNPLA6,

processin MouseMeta:magenta_M8_Mic ZNF335, AHI1

g; roglia(Type2)

go:CC|an

aphase-

promoting

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 complex;

genefamil

y:ZNF|Zi

nc

fingers,

C2H2-

type

The top 3 gene sets for known molecular pathways and biological processes or

hypothesis driven gene sets are shown. The top 5 intramodular hub genes (bases on

module membership) is shown.

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable 8. Summary of genetic enrichment with coexpression modules.

Dise Gene set Vari Module Modul Overlappi P Genes

ase ant e size ng loci

SCZ PGC2-SCZ Com brown 1609 35 0.00299 SLC45A1,RERE SLC4A10

GWAS mon 97 MOB4,PLCL1 C2orf47 CNTN4

TBC1D5 SLC35G2

NDUFA2,PCDHA4 RIMS1

SNAP91 DFNA5 SRPK2

CSMD1 CLU INA ATG13

LRP1,R3HDM2

PITPNM2,RILPL2 PRKD1

BCL11B PPP1R13B PAK6

CHRNA3 UBE2Q2P1

MAN2A2,UNC45A

SEZ6L2,ASPHD1,KCTD13,TM

EM219,MAPK3

CENPT,LCAT,SLC12A4

TOM1L2 MEF2BNB,NCAN

ZNF536 PPP1R16B KCNB1

EP300 CENPM,SEPT3 PJA1

turquoi 2835 46 0.01559 PTPRF DPYD,MIR2682

se 84 PLEKHO1,CA14,C1orf54

SF3B1,HSPE1,MARS2 SATB2

C2orf69 EFHD1 SPCS1

PSMD6-AS2 PCCB,STAG1

FXR1 C4orf27

CDC25C,REEP2

TMCO6,PCDHA2,PCDHA9,PC

DHA11,PCDHAC1 ZSCAN12

FUT9 MPP6,OSBPL3

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 GRM3,KIAA1324L IMMP2L

PTN WBP1L,AS3MT,NT5C2

CKAP5 CTNND1 GRAMD1B

MSANTD2 IGSF9B CACNA1C

TMTC1 NAB2,SHMT2

ATP2A2

C12orf65,CDK2AP1,SETD8

TRMT61A,XRCC3 PSMA4

FURIN DOC2A,PPP4C

ACD,NUTF2 DPH1,SMG6

SREBF1 TCF4 PBX4,LPAR2

RRAS PTGIS L3MBTL2

NAGA,NDUFA6,TCF20

NLGN4X CNKSR2

midnigh 38 3 0.02819 SDCCAG8 SLC38A7 RAI1

tblue 72

yellow 1119 20 0.03179 APH1A CD46 CUL3 GIGYF2

68 NISCH,GLT8D1 PSMD6

PPP2R3A DNAJC19 ZSWIM6

FAM53C ZKSCAN3,ZSCAN23

SFXN2,CNNM2,PCGF6,TAF5,

PDCD11 AMBRA1

TMEM194A OGFOD2

ADAMTSL3 TAOK2

GFOD2,EDC4 SUGP1,MAU2

RANGAP1,ZC3H7B

magent 210 6 0.04079 MAD1L1 ZNF408 TMX2 SRR

a 59 NOSIP ACTR5

CNV Delet yellow 1213 6 0.04779 FMO5 WDR53,NCBP2

ion 52 TUBGCP5 NFATC2IP

PIGW,TADA2A HIRA,GNB1L

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 SCZ de novo NS midnigh 38 6 0.02289 CNDP2 HUWE1(x3)

mutations tblue 95 RAD54L2(x2)

salmon 54 5 0.03777 EMC1 MED29 SLC19A2

92 SMARCC2 TECTA

blue 2513 128 0.03909 AKAP9 AKD1(x2) AKTIP

92 ALDH16A1 ALDH1L2

ALDH4A1 ARHGEF10

ARRDC1 ASH1L BIRC6

BZRAP1 C7orf60(x2) C9orf114

CANX CCDC108 CCDC136

CCDC84 CDKAL1 CHEK2

CHSY1 CIT CLNS1A CLTCL1

CNNM3 CNTN3 COL15A1

COL3A1 COL6A2 DCDC5

DHX8 DMD DNAH9 DUSP15

EML6 EXD3 FAT4 FKBPL FN1

FSD1L GPR153 GRID2 GRIN2A

GTF3C2 GXYLT2 HAUS6

HECTD1 HIF1A HIST1H4I

HTR2A IFT140 INTS5 ITGA3

KIAA1109(x2) KIF6 KPNA1

LDLRAD4 LENG1 LLGL2

MAMDC4 MAN2B2 NEB(x2)

NIP7 NIPAL3(x2) NLRP1

NYNRIN PAG1 PAPPA2

PAQR8 PCDHAC2 PHC2(x2)

PHF7(x2) PIEZO2 PLCL2

PLEKHH1 PML POMT1 PRDX6

PRTG PRUNE2 PTPN3 PTPRG

RASGRP1 RECK RRP1B

SAP30BP SCRN1 SEC31A(x2)

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 SHKBP1 SLC18A2 SLC25A1

SLC3A2 SLC4A8(x2)

SLC9A3R1 SMTNL1 SND1

SORBS2 SOS2 SPAG9 SPATA5

ST3GAL6 STK10 TAF13(x2)

TBC1D14 THBS1 THRA TLK2

TOP3B TTPA UBR5 URB2

UTRN VPS13A WDR11 WRN

XPR1 YARS ZDHHC5 ZNF607

ASD ASD de novo LoF brown 1811 110 2.00E- ACOX2 ADAMTS10

mutations 05 ADAMTS9 ADNP(x4) ANO5

ARHGAP44 ARID1B(x5)

B4GALNT1 BTBD6 BTBD9

C16orf13 CCSER1 CHD2(x3)

CIC CMPK2 DHX57

DIP2A(x2)

DSCAM(x4) DSCAML1 ECM2

ELAVL2 EP400 ETFB

FAM200B FAM91A1 FBXO11

GABRB3 GPRIN1 GRIA2

GRIN2B(x3) HECTD4 HIVEP3

IGSF3 JAKMIP1 KAT6A

KDM5B(x3) L1CAM LDB1

LMTK3 LRP2 LRRTM2

MED13L(x2) MGRN1 MOV10

MYT1L NDST4 NFIA NRXN1

PARD3B PBX1 PDE11A

PHF15 PHF2(x2) PLA2G16

RALGAPB RANBP17(x2)

RAPGEF3 RELN RIMBP2

RIMS1(x2) RUNDC1

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SHANK3 SKIDA1 SLC38A3

SMAP2 SPEN SRCAP SRPK2

SRRM2 STMN4 STXBP5 SVIL

TCF7L2(x2) TRIO TRIP12

UNC79 VAV3 WHSC1

ZFAND5 ZFHX3

cyan 42 5 0.02125 AXL CTNNB1 REPIN1

96 SCNN1D SH3D19

turquoi 3618 144 0.03823 ADAM33 AMOTL1 ANK2(x4)

se 92 APBB1 ASXL3(x2) ATP10D

ATP1B1 BAI1 BNIP1 BRCA1

BST2 C11orf30 C20orf111

CACNA2D3(x2) CBX4

CCDC171 CCDC66 CDAN1

CHD8(x7) COL5A3 CPD

CSDE1 CSMD2 CTNNA3

CTTNBP2 CYP27C1 DDX60

DESI2 DIP2C DLL1 EIF2AK2

FAM65C FAM8A1 FER1L5

FPGS GAREM GLTSCR2

HGF HNRNPD IFI44L

ILF2(x2) IQGAP2 JARID2 JUP

KAL1 KDM1B KIAA0232

KIF21A LIG3 LRRC4 MEGF6

MFSD3 MLL(x2) MLL3(x2)

MLL5(x2) MORC3 MPP6

MYH10 MYH2 NBEA

NCKAP1(x2) NF1 NIN NMT1

NOTCH1 NUDT6 OSBPL3

OSBPL8 PER2 PHF21A

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 PLCD4 PLEKHO1 POGZ(x3)

PRPF40A PSD3 PTPN13

RANBP2 RAPGEF4 RNF38

RPL12 SCN7A SCUBE2

SEMA6A SETD2 SHANK2

SLC25A39 SMURF1 SORCS3

SPAST(x2) SPTBN1 STAM

STARD10 SUCLA2 SUCLG2

SUV420H1(x3) SYNGAP1(x5)

TAF4 TANC2 TCF3 TCF4

TERF2 TMEM39B TRPM3

TSPAN17 TTK TTN TUSC1

UBN2 UBR3 UNC80 URB1

VCPIP1 WDFY3(x2) XKR6

ZC3H14 ZMYND11 ZNF292

ZNF490

NS brown 1811 479 1.00E- A2M ABCA2 ABCA8 ABCC4

04 ABTB1 ACAD10(x2)

ACHE(x3) ACOX2 ACTB

ADAM22 ADAMTS10

ADAMTS9 ADCY5(x2)

ADNP(x4) ADRBK2

AGAP2(x3) AGO1 AGT

AGTRAP AKR1C2(x2)

ANK3(x2) ANKRD13B ANO5

AP3B2 APBA1 APC2

ARHGAP32 ARHGAP44

ARHGEF11 ARID1B(x7)

ASAP2 ATAD3B ATP1A3

ATP2B2 ATP6V1A

B4GALNT1 BRD4 BRF1

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 BRSK1 BSN BTBD6 BTBD9

C16orf13 CABP7 CACNA1B

CACNA1E CAMSAP1

CARD10 CCDC120 CCDC18

CCDC53 CCNI CCSER1

CCT4(x2) CDC42BPA

CDCA7L CDH24 CERS6

CHD2(x6) CHD5 CHGA

CIC(x2) CMPK2 CNN1

CNOT6 COL27A1 CPA4(x2)

CPSF2 CREBBP(x3) CREBL2

CSAD CSMD1(x4) CUX1

DCAF13 DFNA5 DHX57(x2)

DIAPH1 DIP2A(x2) DLG2

DOCK4 DOCK5(x2) DPYSL5

DSCAM(x4) DSCAML1 DTX1

DUOX1 DYNC1I1 ECM2

EEF1A2 EFR3B EGFR(x2)

EIF4A1 ELAVL2 ELAVL3(x2)

ELOVL1 EMC3 EP300

EP400(x2) EPB49 EPHB1(x2)

EPRS(x2) ETFB EVL EXPH5

FAM200B FAM214B

FAM222A FAM91A1 FBLIM1

FBN3 FBXO11(x2) FBXO38

FGF2 FGGY FRY

GABRB3(x3) GALNT9

GLRA2(x2) GNAO1 GNB4

GPN1 GPR179 GPRIN1

GRIA1(x2) GRIA2

GRIN2B(x4) GRK4 GRM5

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 HCN4 HECTD4(x2) HEG1

HERC1(x2) HERC2 HIVEP3

HTATIP2 ICA1 IGSF3 ITGAV

ITGB7 ITPR3(x2) JAKMIP1

JPH3 KAT6A KAZN KCNA4

KCNH7 KDM5B(x6)

KIAA1462 KIAA2022 KIF3C

KIRREL3(x2) L1CAM

LAMA1(x2) LCAT LDB1 LEF1

LHFPL3 LMTK2 LMTK3

LPHN1(x2) LRFN5 LRP1(x3)

LRP11 LRP2(x3) LRRC40

LRRTM2 LTBP3 MADD

MAGEE1 MAP1B MAP2K5

MAPK3(x2) MCF2L2(x2)

MCTP2 MDGA2 MED13L(x2)

MEIS3 METTL16 METTL23

MGRN1 MICAL3 MINK1

MLL2 MNS1 MOB4

MOV10(x2) MRRF MTERFD2

MTMR8 MTMR9 MYLK3

MYO5A(x2) MYT1L(x3)

NBEAL2(x2) NCAN(x2) NCDN

NCOA1 NCOR1 NDST4 NEK2

NFASC NFIA NFXL1 NLGN2

NOTCH2NL NRXN1(x4)

NRXN3 NSUN7 OSBP2

OSBPL9 PACS2 PAK6

PARD3B PARP14 PBX1(x2)

PCDH1 PCDH17 PCNT

PDE11A PDIA2 PDK2 PDZD2

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 PELI1 PFKP PGM2 PHF15

PHF19 PHF2(x2) PITPNM2

PLA2G16 PLCH1

PLEKHA8(x2) PLOD2

POLR2A POM121 PPP1R13B

PPP2R1B PRKD1(x2) PRNP

PROS1 PRRC2C PSMD3

PTAR1 PTBP2 PTPRK

PTPRM(x2) PXDN PXDNL

RALGAPB RANBP17(x3)

RAPGEF3 RASSF3 RBM33

RCOR2 RELN(x3) RERE

REST RIMBP2 RIMS1(x2)

RIMS2 RIN2 RNPEPL1(x2)

RRP8(x2) RUNDC1 RUNDC3B

RUSC2 SCN2A(x14) SEMA3F

SERINC2 SETD5(x4) SGIP1

SH2D3C SH3RF3 SHANK3

SKIDA1 SLC12A4 SLC1A4

SLC24A1 SLC35B2 SLC35E1

SLC38A3 SLC4A2 SLC6A5

SLCO1C1(x2) SMAP2

SMARCA5 SNAP91 SPEN(x3)

SRCAP(x4) SRPK2 SRRM2(x5)

STAU2 STIL STMN4 STXBP1

STXBP5(x2) SUSD4 SVIL

TAOK1 TBC1D30 TCF7L2(x2)

TCTN2 TLR4

TMEM201 TMEM42 TNXB

TOP1 TPST1 TRAK2

TRAPPC9(x2) TRIM46

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 TRIO(x5) TRIP12(x3)

TRRAP(x3) TSC2(x2)

TTLL5(x2) TXNDC16 UACA

UBR4(x3) UNC13A UNC5D

UNC79 VAMP2 VAV3(x2)

WDR45 WHSC1 XYLT2

YWHAG ZC3H3 ZDHHC22

ZFAND5 ZFHX3(x3) ZFP64

ZMIZ2 ZNF106 ZNF318

ZNF438 ZNF445 ZNF451

ZNF527 ZNF559 ZNF665

ZNHIT6 ZRANB3(x2)

ZSWIM1

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 turquoi 3618 769 0.02349 ABCA13(x5) ABCC5(x3)

se 95 ABHD12 ABI2(x2) ACER2

ACP2 ADAM33 ADAMTSL1

ADPRM ADSSL1 AGO4(x2)

AHRR AKAP1(x2) ALDH18A1

ALDH5A1(x2) ALMS1(x2)

AMOTL1 AMY2B ANK2(x7)

ANKHD1 ANKRD27 ANKS1A

ANO6 ANTXR2 ANXA1 AP1S2

AP2S1 AP4E1 APAF1 APBB1

APEX2 AQR ARHGAP21

ARHGEF4 ARHGEF6

ASPHD2 ASPM ASXL3(x2)

ATP10D ATP1B1 ATP2B4

AVEN BAI1 BAI3 BAZ1A

BCHE BMP1 BNIP1 BPNT1

BRCA1 BRCA2(x3) BST2

BTBD11 BTBD2 C10orf137

C11orf30 C19orf70 C20orf111

C2CD3(x2) C4orf27 CABIN1

CACHD1 CACNA1C(x2)

CACNA2D3(x2) CAMK2A

CAPN10 CARS2 CASC5

CATSPERG CBL CBX4

CCBL2 CCDC171 CCDC28B

CCDC57 CCDC66 CCDC90B

CCNB1 CCNJL CD151(x2)

CD320 CD59 CDAN1 CDH13

CDK19 CEBPG CENPI

CEP135(x2) CGNL1 CHD4

CHD8(x10) CHML CHRM3

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COBL(x2) COL5A3

COLEC12(x2) COPS2 CPD

CRY2 CSDE1 CSF1 CSMD2

CTC1 CTNNA3 CTTNBP2

CUL5 CYB5B CYP21A2

CYP27C1 DAP3 DAPK1

DCAF5 DCDC2B DDR2

DDX58 DDX60 DEAF1(x2)

DENND2C DENND5A(x2)

DENR DESI2 DGCR14 DIP2C

DIS3L2(x2) DLC1 DLL1

DMAP1 DMXL2 DNA2

DNAH1(x2) DNAH10(x2)

DNAJC27 DNASE1 DOCK1

DOCK7(x2) DOHH DPY19L3

DPYSL2(x2) DPYSL3 DUS1L

EDIL3 EEF2 EGFL6 EGLN2

EHD2 EIF2AK2 EIF3G

EIF4G2(x2) EPN2 ERCC6L

ETV1 ETV4 FAM129B

FAM208B FAM63B FAM65C

FAM8A1 FANCA FAP FBLN5

FDFT1 FER1L5 FGD3

FLII(x2) FLRT3 FNBP1L

FOXM1 FPGS FYCO1 G3BP2

GADD45B GAREM GDE1

GDI1 GFM2 GIT2 GLI3

GLTSCR2 GNB5 GNPTAB

GOLGA4 GPN3 GPRASP1

GPRIN3 GRAMD1B GRIK1

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 GRM7 GUCY1A3 GYG2

H2AFV HDAC3 HDAC9

HECW2 HELLS HELQ

HELZ2 HGF HID1 HIGD2A

HIST1H2AE HIST1H2BJ

HIST1H3G HMBS HNRNPD

HNRNPUL2 HSPA12A IFI44L

IFIH1 IKBIP IKBKAP

ILF2(x2) IMPDH2 INPP5B

INTS10 IQCE IQGAP2

IQGAP3(x2) ITGB3 ITK(x2)

ITPR1(x2) JAK1 JARID2

JUP(x2) KAL1 KANSL1

KCND3 KCNH3 KCNH8

KCNMA1 KCNQ3 KCTD6

KDELC1 KDM1B KDM2B

KIAA0195(x3) KIAA0232

KIAA1211L KIAA1549

KIAA1984 KIF13B(x2) KIF18A

KIF1A KIF21A(x2) KIF5A

KIFC3 KIRREL2 KLHL25

KLHL4 L3MBTL1 LAMA2

LAMA4 LAMB1(x3)

LAMB2(x2) LHFPL3 LIG3

LIMCH1 LIX1 LNX1(x2)

LPCAT4 LPHN2 LRRC37A3

LRRC4(x2) LSG1 LZTR1

MACF1 MAMLD1 MAN2B1

MANBA MANSC1(x2)

MAP2K6 MAP4(x2) MAP4K5

MAP7 MAPK8IP1 MAST3

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 MBD2 MBNL1(x2) MCFD2

MCM4 MCM6 MDM1

MED12L MED4 MEGF6

MFN1 MFSD3 MGAT4C

MKI67(x2) MLL(x3) MLL3(x5)

MLL5(x2) MMAB MMP15

MMRN1 MMS22L MORC3(x2)

MPP6(x2) MR1 MSH2 MTOR

MVK MXD4 MYCBP2

MYH10(x3) MYH2 MYNN

MYO1C MYOF NACA

NBEA(x2) NBPF8P

NCKAP1(x2) NDNF

NDRG3(x2) NF1(x2) NID2(x2)

NIN NIPAL2 NLGN3(x2)

NLRX1(x2) NMT1 NMT2

NOC2L NOTCH1(x2)

NR2F1(x2) NT5C2 NUDT6

NUMA1(x3) NUP133(x2)

NUP210 OAF OPLAH OSBPL3

OSBPL8 OTUD7A PAFAH1B2

PANK2 PAOX PAPSS2 PBX3

PBX4 PCDH15 PCDHA11

PCDHA2 PCDHA9

PCDHB16(x3) PCNX PCYOX1

PDGFD PDGFRB PDIA4

PDLIM1 PDZRN4 PEPD PER2

PERP PFAS PHACTR2

PHF21A PITPNM3 PKHD1L1

PKN1 PKNOX2 PLAT

PLCD4(x2) PLD5 PLEKHA4

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 PLEKHG1 PLEKHG2

PLEKHO1 PLXNB2 PLXNB3

PMEPA1 POGLUT1 POGZ(x5)

POLA2 POLD1 POLQ(x2)

POU3F4 PPFIA1 PPP1R26

PRKCA(x3) PRPF40A PSD3

PSMD8 PTGFRN(x2) PTGR1

PTPLA PTPN13(x2) PTPN14

PTPRF PUF60 PWWP2A

PYGL QTRTD1 RAB11FIP2

RAB43 RABL6 RAD51

RALGAPA1(x2) RANBP2(x2)

RAPGEF4(x2) RBM27 RBMS3

REV3L RGMA(x2) RGS12

RIC8A RNF216 RNF38 RNF4

RNF6 RPL12 RPL14 RPL21

RPL35 RRP12 RUFY1 RYR3

SATB2 SCG2 SCN1A(x3)

SCN3A SCN7A SCUBE2(x2)

SCYL1 SDC3(x2) SDHA SDK1

SEC23A SEMA4C SEMA4G

SEMA5A SEMA6A SENP7

SEPT10 SESN1 SETD2(x2)

SETX(x2) SF3B1(x3) SGSM1

SH3YL1 SHANK2 SIK1 SKA3

SKIL SLC12A9 SLC16A3

SLC16A9 SLC22A23(x2)

SLC25A39 SLC25A43

SLC2A10 SLC35C2(x2)

SLC6A1(x4) SLC9A3

SLITRK5(x2) SLK SLX4(x2)

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 SMAD2 SMG6 SMG7 SMURF1

SNRK SOAT1 SOGA2(x3)

SORCS3 SOS1 SOX6

SP110(x2) SP3 SPAST(x2)

SPECC1L(x3) SPON2(x2)

SPTAN1 SPTBN1(x2) SRD5A3

SRGAP3(x2) ST7L STAG1

STAG3 STAM STARD10

STARD4 STAT5A STRN3

STT3A STUB1 SUCLA2

SUCLG2 SULF2 SUPT16H

SUV420H1(x5) SV2A

SYNE1(x6) SYNGAP1(x8)

SYT1 SYT14 SZT2 TAF4 TAF9

TANC2(x2) TANK TAOK3(x2)

TBCB TBK1 TCF3(x2) TCF4

TCF7L1 TENC1 TENM4

TERF2(x2) TFAP4 TFIP11

THRAP3 TIAL1 TLE3

TMEM178A TMEM39B(x2)

TNIK TNPO3(x2) TNRC6A

TOP1MT TP53BP1 TPBG

TRAF7 TRAK1 TRIP11

TROAP TRPM3 TSPAN17

TTC17 TTF2 TTK TTN(x15)

TUBA1A(x2) TUBB4B

TUBGCP2 TUBGCP4 TULP4

TUSC1 TUSC2 TUT1 UBAP2

UBB UBN2(x2) UBR3(x2)

UBXN6 UGGT2 UNC80(x2)

UPF3A URB1(x2) USP21

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VPRBP VPS39 VPS54

WBSCR17 WDFY3(x5)

WDHD1 WDR66 WDR67

XKR6 XRN2 YIPF5

ZBTB38(x2) ZC3H14 ZFP69

ZFPL1 ZFPM2 ZFYVE20

ZFYVE9 ZKSCAN5(x2)

ZMAT5 ZMYND11 ZNF213

ZNF219 ZNF292 ZNF382(x2)

ZNF490 ZNF530 ZNF532

ZNF555(x2) ZNF77 ZNF774

ZXDC

Epile Epilepsy de novo LoF brown 1811 16 0.00089 AP3S2 BCLAF1 CHD2 DCX

psy mutations 9982 DNAJC6 ETNK2 FBXO41

MRS2 MYO5A PIGS

RALGAPB RGS14 STX1B

STXBP1 UBQLN4 WDR45

NS brown 1811 65 0.00011 A2M ANK3 AP3S2 BCLAF1

9998 CACNA1E CAMK4 CASP9

CDC25B CEP55 CHD2 CNTN5

DCX DNAJC6 ETNK2 EXPH5

FBXO41 GABRB3(x4) GAS2

GLUL GNAO1(x2) GRIN2B

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MAST1 MLL2(x2) MRS2

MYO3A MYO5A NEDD4L

NFASC NLGN2 PACS2 PIGS

PNMAL1 PTPRO RALGAPB

RALGPS1 RGS14 SCN2A(x3)

SCN8A(x2) SLC1A2 STX1B

STXBP1(x5) TAF1 TRIO

TRRAP UBQLN4 WDR45

WHSC1L1 YWHAG ZC3H3

ZFHX3

ID ID de novo LoF brown 1811 17 0.00125 AGBL5 ARID1B CHD2(x2)

mutations 997 GATAD2B(x2) LRP2 MED13L

MYT1L SCN2A(x4) SETD5

STXBP1 WDR45(x2)

midnigh 38 2 0.01821 CDC42BPB RAI1

tblue 96

NS brown 1811 57 2.00E- AGBL5 AGO1(x2) ARID1B

05 CHD2(x2) CREBL2 DGKH

DOCK9 DOK4 EEF1A2

EPHB1 ERV3-1 FHDC1

GABRB3 GATAD2B(x2)

GRIA1 GRIN2B(x2) KIF5C

LHFPL3 LRP1 LRP2 MAST1

MED13L(x2) MGAT5B

MYT1L NAA10 OSBPL9

PIK3R3 R3HDM1 RANBP17

SCN2A(x5) SCN8A SET

SETD5 SEZ6 SLC6A5 SPOCD1

STXBP1(x3) STXBP5 TBKBP1

TPM2 TRIO(x2) WDR45(x2)

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Downloaded From: https://jamanetwork.com/ on 10/01/2021 ZMYND12 ZNF540

midnigh 38 3 0.03955 CDC42BPB RAI1(x2)

tblue 92

Overlap between coexpression modules in the control network with various sets of genetic data from schizophrenia

case-control studies, including that of common variation (GWAS), rare CNV, de novo mutations, and de novo

mutations across neurodevelopmental diseases, including autistic spectrum disorder (ASD), intellectual disability (ID)

and epilepsy. Only enrichment at P < 0.05 is shown. In a single interval with more than one gene, genes are separated

by commas. NS: non-synonymous; LoF: loss-of-function mutations.

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