Annual Report 2009 Department of Biostatistics University Of

Annual report 2009

Department of Biostatistics

Preface

The Department of Biostatistics is part of the Institute of Public Health, Faculty of Health Sciences, University of Copenhagen. The present annual report documents the activities of the scientific staff during 2009. Hopefully, the report may also serve as an introduction to the department. The report documents research projects, teaching and advisory work, as well as editorial and other organizational activities for the biostatistical community. The reader will find lists of publications, talks and travels of the scientific staff, a list of visitors to the department and a list of talks in our seminar series. Annual reports have been published since the start of the department as a research council initiative in 1978. The present version follows the tradition in many ways, with two exceptions: the report is now only in English, and the production has been mod- ernized. The new production process is based on the Semantic Mediawiki Project and has been implemented by Thomas A. Gerds with technical assistance by Tim F. Olsen and Klaus K. Holst and administrative assistance by Susanne Kragskov, Stine Sparre Kjær Urhøj, Jeanette Pollmann, Emilie Just-Østergaard and Kathe Jensen. Editorial details have been discussed with Esben Budtz-Jørgensen and Niels Keiding. The annual report is available on the website https://intra.ifsv.ku.dk/biostat_ annualreport/index.php5/Annual_reports which contains electronic search possibil- ities. The Department of Biostatistics is the biostatistical resource for all parts of the Faculty of Health Sciences, which implies some special features in the daily work of the department. In addition to research and teaching in the department’s core academic competence (biostatistics), the scientific staff has an extensive portfolio of collaborative medical research, advisory and consulting activities at several levels, and an extensive program of teaching of statistics to users within the faculty.

Copenhagen, November 2010

Niels Keiding

Department of Biostatistics, University of Copenhagen Øster Farimagsgade 5, DK-1014 Copenhagen K, Denmark Email: biostat @ biostat.ku.dk, Telephone: +45 35 32 79 01, Fax: +45 35 32 79 07

Contents

Preface ...... 3 Personnel ...... 7 External funding ...... 8

Research 9 1 Legend ...... 9 2 Statistical theory and methods ...... 10 2.1 Biostatistics ...... 10 2.2 Demography ...... 17 2.3 Epidemiology ...... 17 2.4 Mathematical statistics ...... 19 2.5 Statistical genetics ...... 19 3 Applied statistical collaborations ...... 20 3.1 Clinical research ...... 20 3.2 Epidemiology ...... 32 3.3 Public health ...... 39 3.4 Statistical genetics ...... 40 4 Statistical software development ...... 41 5 Core facility ...... 42 5.1 Core Facility: Projects ...... 42 5.2 Core Facility: Publications ...... 45

Statistical community 47 1 Advisory and journal activities ...... 47 2 International collaboration ...... 49 2.1 Visitors ...... 49 2.2 Seminar ...... 51 3 External presentations of members of the department ...... 53 3.1 Talks ...... 53 3.2 Travels ...... 57

Teaching 61 1 Courses ...... 61 1.1 Ph.D. courses ...... 61 1.2 Master / Bachelor courses ...... 62 2 Supervision ...... 62 3 Publications ...... 65 3.1 Journal articles ...... 65

5 CONTENTS

3.2 Research reports ...... 73

6 CONTENTS

Personnel

In 2009 the Department of Biostatistics (University of Copenhagen) employed the following people:

Professor Research Assistant

Per Kragh Andersen Nina Breinegaard (since 1 July 2009) Niels Keiding Randi Grøn (1 March 2009 to 30 November Svend Kreiner 2009) Thomas Scheike Marie-Louise Hansen (until 31 January 2009) Maja Olsbjerg Larsen (since 1 August 2009) Associate Professor Jeremy Silver (until 28 February 2009) Louise Stage (until 31 January 2009) Esben Budtz-Jørgensen Karl Bang Christensen Computing Assistant Peter Dalgaard Thomas Alexander Gerds Jacob Blindum (since 1 April 2009) Jørgen Holm Petersen Sara Brebbia Lene Theil Skovgaard Nina Breinegaard (until 30 June 2009) Therese Graversen Assistant Professor Randi Grøn (until 28 February 2009) Oluf Kristian Højbjerg Hansen Julie Lyng Forman Martin Theil Jensen Theis Lange (since 14 April 2009) Kira Svendsen

Phd Student Administrative Staff

Anders Albrechtsen (until 31 May 2009) Marianne Arnecke (until 31 January 2009) Mette Gerster (until 31 March 2009) Diana Bech (since 19 January 2009) Randi Grøn (since 1 December 2009) Kathe Jensen Klaus K¨ahlerHolst Emilie Just-Østergaard Bruno Paul Mmbando Susanne Kragskov Laupstad Ulla Brasch Mogensen Tim Frederik Olsen Lisbeth Nørgaard Møller Jeanette Pollmann Lars Hougaard Nielsen (until 28 February Stine Sparre Kjær Urhøj 2009) Janne Petersen Kyle Raymond (since 14 September 2009) Susanne Rosthøj (until 28 February 2009)

Post Doc

Susanne Rosthøj (since 1 March 2009)

7 External funding

External funding

In 2009, several people were partly ﬁnanced by external sources. External funding was coming from NIH (joint project with John Klein) the Graduate School in Biostatistics funded by the Danish Research Councils (Niels Keiding leader). Further external funding was coming from several national and international fonds through collaboration with the following people: Henrik Leﬀers (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark), Jesper Møller (Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark) Philippe Grand- jean (Environmental Medicine, University of Southern Denmark, Odense, Denmark) Niels Erik Skakkebæk (Department of Growth and Reproduction, Copenhagen Uni- versity Hospital, Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychi- atry, Copenhagen University Hospital, Copenhagen, Denmark), Bent Ottesen (The Juliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark), Sig- urd Mikkelsen (Department of Occupational Medicine, Glostrup University Hospital, Glostrup, Denmark), Ulrik Gether (Molecular Neuropharmacology Group, Depart- ment of Pharmacology, University of Copenhagen, Copenhagen, Denmark)

8 Research

The department conducts biostatistical research and software development, partici- pates in substantive research projects applying statistical methods, and offers biostatistical advice to PhD students and staff in all disciplines of the Faculty of Health Sciences, including those engaged in experimental and clinical medicine, public health, and oral health. Furthermore, an important part of the research work is done in short and long-term collaborations with researchers from outside the Faculty and from all over the world. In this section the research activities from the year 2009 are listed in the subsections methodological research, applied collaborations and development of statistical software. Research activity corresponding to the Core Facility of Biostatistics are col- lected in a separate subsection. Further structure is obtained from Keywords (Topics) that have been submitted by the responsible scientific staff for the single projects. For some projects more information is available at the Internet site of this annual report.

1 Legend

Throughout this chapter projects are listed in the following form:

Project title Staﬀ members of the Department of Biostatistics External collaborators (Aﬃliations)

9 Statistical theory and methods

2 Statistical theory and methods 2.1 Biostatistics Diagnostic and predictive models Methods for constructing age-speciﬁc 2-dimensional reference charts for reproductive hormones Jørgen Holm Petersen

Survival paths through the forest Ulla Brasch Mogensen, Thomas Alexander Gerds Jørgen Olsen (Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark), Tom Skyhøj Olsen (Department of Neurore- habilitation, The Stroke Unit, Hvidovre University Hospital, Hvidovre, Denmark), Ole Winther (The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark)

Guidelines for the use of ROC curves in the evaluation of diagnostic tests Jørgen Hilden

Assessment of added diagnostic and prognostic power Jørgen Hilden, Thomas Alexander Gerds Per Winkel (Copenhagen Trial Unit (CTU), Centre for Clinical Intervention research, Copenhagen University Hospital, Copenhagen, Denmark)

Epidemiological methods History of confounder control: weighting, modelling, standardization Niels Keiding David Clayton (Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge University, Cambridge, England)

10 Statistical theory and methods

Event history analysis Extending the C-index for survival analysis Thomas Alexander Gerds Michael Kattan (Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, USA), Martin Schumacher (Institute of Medical Biometry, University of Freiburg, Freiburg, Germany)

Graphical goodness of ﬁt methods for survival data based on pseudo- observations and Pseudo-observations in survival analysis Per Kragh Andersen Maja Pohar Perme (Institute of Biomedical Informatics, University of Ljubljana, Ljubljana, Slovenia)

Relative survival based on the proportional excess hazards model and the additive hazards model Thomas Scheike Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Theoretical properties of the pseudo value approach to regression modelling in the presence of right censoring and competing risks Thomas Alexander Gerds Frederik Graw (Institute of Integrative Biology, ETH Zurich, Z¨urich, Switzerland), Martin Schumacher (Institute of Medical Biometry, University of Freiburg, Freiburg, Germany)

Model selection for survival data, including the lasso and Dantzig selector. Thomas Scheike Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark)

Longitudinal risk evaluation tool for sickness absence, unemployment, return to work and disability pension Karl Bang Christensen Jacob Pedersen (Danish National Research Centre for the Working Environment, Copenhagen, Denmark)

Describing association for competing risks data Thomas Scheike Yanqing Sun (Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, USA)

11 Statistical theory and methods

Frailty models in case-cohort studies Per Kragh Andersen Liselotte Petersen, Thorkild Sørensen (Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark)

Random eﬀects models for competing risks data Thomas Scheike Mei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee, USA), Yanqing Sun (Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, USA), Tina Kold Jensen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark)

High-dimensional covariates for survival data and their use for the case- cohort design Thomas Scheike Anders Gorst Rasmussen (Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark)

Frailty models for the additive risk model Thomas Scheike Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark), David Zucker (Department of Statistics, Hebrew University, Mount Scopus, Jerusalem, Israel)

Haplotype eﬀects in the additive hazards model Thomas Scheike Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark), Mei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee, USA)

Haplotype eﬀects on the cumulative incidence function for competing risks data: An application to BMT data. Thomas Scheike Mei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee, USA)

Competing risks in epidemiology Per Kragh Andersen Hein Putter (Leiden University Medical Centre, Leiden, Holland), Ronald Geskus (Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands)

12 Statistical theory and methods

Flexible regression modelling for survival data Thomas Scheike Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark), Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Flexible competing risks regression using R Thomas Scheike Mei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee, USA)

Competing risks models with time-dependent covariates Per Kragh Andersen Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Case cohort design Thomas Scheike Yanqing Sun (Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, USA)

Heritability for survival data Klaus K¨ahlerHolst, Jørgen Holm Petersen, Thomas Scheike

Competing risks problems for BMT patients Thomas Scheike Mei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee, USA)

Approximation of Event History Models Randi Grøn, Thomas Alexander Gerds, Per Kragh Andersen Søren Feodor Nielsen (Copenhagen Business School, Copenhagen, Denmark)

Explained variation in a fully speciﬁed model for data-grouped survival data with application to ﬂowering of sugar beet plants Thomas Scheike Christian Ritz (Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark), Christian Pipper (Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark)

Estimation of haplotype eﬀects for survival data Thomas Scheike, Jeremy Silver Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark)

13 Statistical theory and methods

Methods for analysing repeated events in aﬀective disorders Tine Kajsa Kvist, Per Kragh Andersen Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Multi-state models in bone marrow transplantation studies Per Kragh Andersen Maja Pohar Perme (Institute of Biomedical Informatics, University of Ljubljana, Ljubljana, Slovenia)

Partial Least Squares for the additive hazards model Thomas Scheike Torben Martinussen (Department of Biostatistics, University of Southern Denmark, Odense, Denmark)

Algorithms for analysing interval censored survival data in dental research Niels Keiding, Thomas Alexander Gerds, Randi Grøn Halina Frydman (Stern School of Business, New York University, New York, USA), Daniel Commenges (INSERM, Epidemiology and Biostatistics Research Center, Bordeaux, France), Pierre Joly (INSERM, Epidemiology and Biostatistics Research Center, Bordeaux, France), Vibeke Qvist (Department of Cariology and Endodontics, Faculty of Health Sciences, School of Dentistry, University of Copenhagen, Copen- hagen, Denmark)

The prediction error of risk prediction models in survival analysis Thomas Alexander Gerds Martin Schumacher (Institute of Medical Biometry, University of Freiburg, Freiburg, Germany)

Graphical models Applying graphical models to the adoption study design Jørgen Holm Petersen Thorkild I.A. Sørensen (Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark)

Assessment of model search procedures in graphical models by Monte Carlo and Bootstrap methods Svend Kreiner Volkert Siersma (Section and Research Unit of General Practice, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Functional collapsibility in chain graph models Svend Kreiner

14 Statistical theory and methods

Marginalization and conditioning in chain graph models Svend Kreiner, Jørgen Holm Petersen Volkert Siersma (Section and Research Unit of General Practice, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Item response models Item analysis by stochastically ordered mixture Rasch models Svend Kreiner

Item analysis by graphical loglinear Rasch models Karl Bang Christensen, Svend Kreiner

IRT models with uniform local dependence Svend Kreiner

Assessment of targeting of IRT models Svend Kreiner

Exact properties of person estimates in Rasch models Svend Kreiner

Latent class models Deﬁnition of syndromes by latent variables: HIV-associated lipodystrophy syndrome Janne Petersen, Esben Budtz-Jørgensen Klaus Larsen (Lundbeck A/S, Copenhagen, Denmark), Ove Andersen (Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark)

Latent variable models Estimation of variance Components in the Rasch Model Jørgen Holm Petersen, Karl Bang Christensen, Jacob Blindum

Approximative likelihood inference in latent variable variable models with nonlinear structural eﬀects Klaus K¨ahlerHolst, Esben Budtz-Jørgensen

15 Statistical theory and methods

Ordered categorical data Models for repeated ordinal measurements Svend Kreiner

Standardized gamma coeﬃcients for loglinear models Svend Kreiner Volkert Siersma (Section and Research Unit of General Practice, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Analysis of rater agreement by item response models Svend Kreiner, Jørgen Holm Petersen Klaus Larsen (Lundbeck A/S, Copenhagen, Denmark)

Repeated measurements and functional data Statistical analysis of gait data quantified by measurements of angular rotations of different joints using functional data analysis Klaus KählerHolst, Thomas Scheike, Jørgen Holm Petersen

Structural equation models Latent variable models in neuroimaging Klaus K¨ahlerHolst, Esben Budtz-Jørgensen Gitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark)

Structural equation models in environmental risk assessment Esben Budtz-Jørgensen, Niels Keiding Philippe Grandjean (Institute of Public Health, University of Southern Denmark, Odense, Denmark)

16 Statistical theory and methods

2.2 Demography Abortion parity and birth parity speciﬁc abortion rates and birth rates Niels Keiding, Ditte Mølgaard-Nielsen, Marie-Louise Hansen, Louise Stage

Application of age-period-cohort models for describing fertility variations and variation in abortion frequency Niels Keiding Lisbeth B. Knudsen (Department 1 - Department of Sociology, Social Work and Organisation, Aalborg University, Aalborg, Denmark), Katrine Strandberg-Larsen (Centre for Alcohol Research, National Institute of Public Health,University of Southern Denmark, Copenhagen, Denmark)

Methods for determining the causal eﬀect of female education and labour market participation on fertility Mette Gerster, Niels Keiding Lisbeth B. Knudsen (Department 1 - Department of Sociology, Social Work and Organisation, Aalborg University, Aalborg, Denmark), Katrine Strandberg-Larsen (Centre for Alcohol Research, National Institute of Public Health,University of South- ern Denmark, Copenhagen, Denmark), Mette Erjnæs (Department of Economics, University of Copenhagen, Copenhagen, Denmark), Trude Lappeg˚ard(Statistics Norway, Research department, Oslo, Norway)

2.3 Epidemiology Causal inference Mediation analysis in a survival context Theis Lange

Dynamic treatment strategies Dynamic statistical modelling of maintenance therapy of children with acute lymphoblastic leukaemia Susanne Rosthøj, Niels Keiding Kjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

17 Statistical theory and methods

Epidemiological methods Assessing safety limits in environmental epidemiology Esben Budtz-Jørgensen, Niels Keiding Philippe Grandjean (Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Methods of estimating time to pregnancy Niels Keiding, Oluf Kristian Højbjerg Hansen Rémy Slama (Institut national de la santéet de la recherchémédicale,University J Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Grenoble, France), RenéEijkemans (Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Nether- lands)

Model averaging in risk assessment Esben Budtz-Jørgensen, Niels Keiding Philippe Grandjean (Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Methodological problems in vaccine studies in developing countries Per Kragh Andersen Henrik Ravn (Bandim Health Project, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark), Paddy Farrington (Department of Mathe- matics and Statistics, The Open University, Milton Keynes, England)

The concept of biological interaction in epidemiology Per Kragh Andersen Anders Skrondal (Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway)

Pharmacoepidemiology The problems of the use of prescription databases to assess the risk of side eﬀects of hormone therapy Lars Hougaard Nielsen, Niels Keiding Anne Helms Andreasen (Research Centre for Prevention and Health, Glostrup Uni- versity Hospital, Glostrup, Denmark), Yrsa Andersen Hundrup (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark), Ellen Løkkegaard (Department of Gynecology and Obstetrics, Hillerød Hospital, Hillerød, Denmark)

18 Statistical theory and methods

2.4 Mathematical statistics Asymptotic statistical theory Heavy tail asymptotics in explosive time series models Theis Lange Søren Johansen (Department of Economics, University of Copenhagen, Copenhagen, Denmark)

Diffusion models Goodness of ﬁt test for diﬀusion-type models based on estimating functions Julie Lyng Forman Helle Sørensen (Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark), Bo Markussen (Department of Basic Sciences and Environ- ment, University of Copenhagen, Copenhagen, Denmark)

Statistical modeling of protein dynamics Julie Lyng Forman Michael Sørensen (Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark), Jesper Lund Pedersen (Department of Mathematical Sci- ences, University of Copenhagen, Copenhagen, Denmark), Jesper Ferkinghoﬀ-Borg (Department of Medicine and Technology, DTU-Elektro, Lyngby, Denmark), Sandro Bottero (Department of Medicine and Technology, DTU-Elektro, Lyngby, Denmark), Thomas Hamelryck (The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark)

Measurement error Calculating the age of the universe Jørgen Holm Petersen, Klaus K¨ahlerHolst, Esben Budtz-Jørgensen, Jacob Blindum

2.5 Statistical genetics Diagnostic and predictive models Modelling microarray and metabolite data to improve the diagnosis of inﬂammatory bowel disease patients Thomas Alexander Gerds, Ulla Brasch Mogensen Jørgen Olsen (Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark), Morten Hansen (Department of Cardiology, Bispebjerg University Hospital, Bispebjerg, Denmark)

19 Applied statistical collaborations

Statistical genetics Recombinations eﬀect on the site frequency spectrum and biased gene conversions Anders Albrechtsen Ines Hellmann (Departments of Integrative Biology and Statistics, University of California, Berkeley, USA), Rasmus Nielsen (Department of Biology, University of Copenhagen, Copenhagen, Denmark)

Comparison of statistical methods for analysing metabolic data Thomas Alexander Gerds, Anders Albrechtsen Tune Pers (Center for Biological Sequence Analysis, Department of Systems Biology, The Technical University of Denmark, Lyngby, Denmark), Thorkild I.A. Sørensen (Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark), Claus Holst (Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark)

A new method for detecting IBD regions in multiple individuals: making disease mapping based on very few individuals possible Anders Albrechtsen Ida Moltke (The Bioinformatics Centre, Department of Biology, University of Copen- hagen, Copenhagen, Denmark), Rasmus Nielsen (Department of Biology, University of Copenhagen, Copenhagen, Denmark)

3 Applied statistical collaborations 3.1 Clinical research Anaesthesiology Various neuromuscular blocking agents Lene Theil Skovgaard Jørgen Viby Mogensen (Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark)

Long-term Consequences of Postoperative Cognitive Dysfunction Karl Bang Christensen Jacob Steinmetz (Department of Anesthesia, Center of Head and Orthopedics, Copen- hagen University Hospital, Copenhagen, Denmark), Lars Rasmussen (Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark)

20 Applied statistical collaborations

Predictive risk factors for postherniotomy pain Julie Lyng Forman Eske Aasvang (Section of Surgical Pathophysiology, Copenhagen University Hospital, Copenhagen, Denmark), Henrik Kehlet (Section of Surgical Pathophysiology, Copen- hagen University Hospital, Copenhagen, Denmark)

Eﬀect of acute and delayed hyperbaric oxygen therapy on cyanide whole blood levels during acute cyanide intoxication. Esben Budtz-Jørgensen Pia Lawson-Smith (Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark)

Mast cell tryptase in patients with suspected allergic reactions during anesthesia Lene Theil Skovgaard Lene Heise (Gentofte University Hospital, Gentofte, Denmark)

Variation in stroke volume under ﬂuid therapy Lene Theil Skovgaard Morten Bundgaard-Nielsen (Department of Anaesthesia, Copenhagen University Hospital, Copenhagen, Denmark)

Biomedical optics Precision of continuous estimation of cerebral autoregulation by near- infrared spectroscopy in preterm infants Karl Bang Christensen Gitte Holst Hahn (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark)

21 Applied statistical collaborations

Cancer incidence and cancer prognosis Social inequality in cancer Theis Lange Ulla Hvidtfeldt (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark), Naja Hulvej Rod (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Den- mark), Finn Diderichsen (Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark), Ingelise Andersen (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Colorectal polyps and their role in the development of colorectal cancer Lene Theil Skovgaard Mahin Mohammadi (Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark)

Hormonal treatment and risk of ovarian cancer Lene Theil Skovgaard Lina Mørch (Institute of Public Health, University of Southern Denmark, Copen- hagen, Denmark)

Cardiology DANTRIP: collaboration on pharmacoepidemiological approach to cardiovascular epidemiology Niels Keiding Christian Torp-Petersen (Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark)

Quantifying the predictive power of new markers for predicting events in the presence of competing risks. Thomas Alexander Gerds Thomas Sehestedt (Cardiovascular Research Unit, Glostrup University Hospital, Copenhagen, Denmark)

Morphological appearances of the stent/vessel wall complex Lene Theil Skovgaard Maria Radu (Cardiologic Laboratory, Copenhagen University Hospital, Copenhagen, Denmark)

22 Applied statistical collaborations

Home-based cardiac rehabilitation among elderly with coronary heart disease Lene Theil Skovgaard Bodil Ørkild (Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark)

Depression in patients with coronary artery disease trial (DECARD) Susanne Rosthøj Jamal A Hanash (Psychiatric Centre, Bispebjerg University Hospital, Copenhagen, Denmark)

Diabetes Eﬀect of rehabilitation of patients with type 2 diabetes, in comparison to advisory lifestyle intervention Lene Theil Skovgaard Eva Soelberg Vadstrup (Bispebjerg University Hospital, Copenhagen, Denmark)

Fertility Risk charts predicting ovarian response Thomas Alexander Gerds, Julie Lyng Forman, Jeremy Silver Nina La Cour Freiesleben (The Fertility Clinic, The Juliane Marie Center, Copen- hagen University Hospital, Copenhagen, Denmark), Anders Nyboe Andersen (Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark)

Power calculations for eﬀect of YKL on pregnancy problem outcomes Thomas Scheike Dorte Brask (Neurobiology Research Unit, Copenhagen University Hospital, Copen- hagen, Denmark)

Reference curves for AMH Thomas Scheike Trine Holm Johannsen (Department of Clinical Biochemistry, Herlev University Hos- pital, Herlev, Denmark), Lennart Friis-Hansen (Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark)

Timing of menopause based on the twin registry Thomas Scheike Tina Kold Jensen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark), Annette Tønnes Pedersen (Clinic of Gynaecology, Copenhagen University Hospital, Copenhagen, Denmark)

23 Applied statistical collaborations

Morbidity in children born after assisted reproductive technology - A Scandinavian study Julie Lyng Forman Anna-Karina Aaris (The Fertility Clinic, Copenhagen University Hospital, Copen- hagen, Denmark), Anja Pinborg (Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark), Anders Nyboe Andersen (Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark)

Overstimulation at fertility treatment Thomas Scheike Mette Toftager (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark)

Relationship between body mass index and outcome of fertility treatment Per Kragh Andersen Lone Schmidt (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Gastroenterology A meta-analysis of nitroglycerine treatment in pancreatitis Per Kragh Andersen Camilla Nøjgaard (Department of Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark)

Multistate models in prognostic studies in liver cirrhosis Per Kragh Andersen Peter Jepsen (Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark)

Prognostic studies in liver cirrhosis Per Kragh Andersen Peter Jepsen (Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark)

24 Applied statistical collaborations

Growth and reproduction Maternal use of nicotine replacement therapy during pregnancy, and its relation to oﬀspring Lene Theil Skovgaard Tina Harmer Lassen (Department of Growth and Reproduction, Copenhagen Univer- sity Hospital, Copenhagen, Denmark)

Vitamin D metabolism in human spermatozoa Jørgen Holm Petersen Martin Blomberg Jensen (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Gynaecology Register-based analysis on venous thrombosis among pregnant women in Denmark 1995-2005 Ulla Brasch Mogensen, Anne Louise Svendsen Øjvind Lidegaard (Gynecologic Clinic, Copenhagen University Hospital, Copenhagen, Denmark)

Heart diseases Childhood growth and heart diseases in adulthood Per Kragh Andersen Michael Gamborg (Institute of Preventive Medicine, Copenhagen University Hospi- tal, Copenhagen, Denmark), Thorkild Sørensen (Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark)

The prognostic effect of heart-rate rhythm on different outcomes. Thomas Scheike Uffe Gang (Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark)

Metformin treatment is associated with reduced mortality in diabetes patients with heart failure Theis Lange Charlotte Andersson (Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark), Christian Torp-Petersen (Department of Cardiology, Gentofte University Hospital, Gentofte, Denmark)

25 Applied statistical collaborations

CLARICOR project: Antibiotics and ischaemic heart disease Jørgen Hilden Christian Gluud (Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen, Denmark)

Lung medicine Development of lung function for patients with Primary Ciliary Dyskinesia Lene Theil Skovgaard June Kehlet Marthin (Pediatric Pulmonary Service and Cystic Fibrosis Centre, Copenhagen University Hospital, Copenhagen, Denmark)

Malaria research Weight loss for mice with malaria Lene Theil Skovgaard Jørgen Kurtzhals (Department of Clinical Microbiology, Copenhagen Unicersity Hospital, Copenhagen, Denmark)

Neurology Socioeconomic risk factors for Tourette’s syndrome Niels Keiding, Kira Svendsen Nanette Mol Debes (Pediatric Department, Glostrup University Hospital, Glostrup, Denmark)

Immunoglobulin treatment of patients with Inclusion body myositis (IBM) Lene Theil Skovgaard Nanna Witting (Department of Neurology, Copenhagen University Hospital, Copen- hagen, Denmark)

Fat metabolism in patients with neuromuscular disorders Lene Theil Skovgaard Mette Cathrine Ørngreen (Neuromuscular Research Unit, Copenhagen University Hospital, Copenhagen, Denmark)

Diagnosis of Lyme borreliosis Jørgen Hilden Ram Dessau (Department of Clinical Microbiology, Næstved Hospital, Næstved, Denmark), Tove Ejlertsen (Department of Clinical Microbiology, Aalborg Hospital, Aalborg, Denmark)

26 Applied statistical collaborations

DAISY: Psycho-social intervention project for dementia patients Niels Keiding Gunhild Waldemar (Memory Disorders Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark), Frans Waldorﬀ (Research Unit and Department of General Practice, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Oncology Maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia Susanne Rosthøj Kjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

Postmenopausal hormone therapy and cancer risk based on prescription registry Niels Keiding, Lars Hougaard Nielsen Ellen Løkkegaard (Department of Gynecology and Obstetrics, Hillerød Hospital, Hillerød, Denmark), Yrsa Andersen Hundrup (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark), Anne Helms Andreasen (Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark)

DNA-incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma Susanne Rosthøj Kjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark), Rikke Hedeland (Section for Pediatric Hematology and Oncology, Pediatric Clinic II, The Juliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark)

Inclusion of white blood count in risk stratiﬁcation of treatment protocols for childhood acute lymphoblastic leukaemia. Susanne Rosthøj Kjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark), Goda Vaitkeviciene

Survival of patients developing cardiotoxicity after epirubicin treatment for breast cancer Per Kragh Andersen, Martin Theil Jensen Marianne Ryberg (Department of Oncology, Herlev University Hospital, Herlev, Denmark)

27 Applied statistical collaborations

F18-cholin-PET imaging in the staging of cancer prostatae Jørgen Hilden Jørn Theil Nielsen (Department of Clinical Physiology and Nuclear Medicine, Aarhus Universitt Hospital, Skejby, Aarhus, Denmark), Bodil Engelmann (Department of Gastrointestinal Surgery D, University Hospital of Glostrup, Copenhagen, Denmark), Liselotte Højgaard (Department of Clinical Physiology and Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen, Denmark)

MTHFR polymorphisms in treatment of colo-rectal cancer Per Kragh Andersen Shoaib Afzal (Institute of Forensic Medicine, University of Aarhus, Aarhus, Denmark)

Monitoring of chemotherapy of children with acute lymphoblastic leukaemia Susanne Rosthøj, Niels Keiding Kjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

Ophthalmology Optical coherence tomography is related to intracranial pressure and visual ﬁeld sensitivity in idiopathic intracranial hypertension Thomas Alexander Gerds Maren Skau (Danish Headache Center, Glostrup University Hospital, Glostrup, Denmark)

Risk factors of retinopathy of prematurity Julie Lyng Forman Carina Slidsborg (Department of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Morten la Cour (Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital, Copenhagen, Denmark)

A register based study of normal tension glaucoma and risk of dementia Ulla Brasch Mogensen, Julie Lyng Forman, Per Kragh Andersen Daniella Bach Pedersen (Gluacoma Clinic, Eye Clinic, Rigshospitalet, Copenhagen, Denmark), Svend Vedel Kessing (Gluacoma Clinic, Eye Clinic, Rigshospitalet, Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Retinal function in diabetic patients Lene Theil Skovgaard Stig Holfort (Dept. of Ophtalmology, Glostrup Hospital, Glostrup, Denmark)

28 Applied statistical collaborations

Oral health research Qualitative interview and questionnaires are investigated as tools for anamnesis in oral rehabilitation Lene Theil Skovgaard Esben Ozhayat¨ (Department of Odontology, University of Copenhagen, Copenhagen, Denmark)

A radiographic study of bone grafts after maxillary sinus ﬂoor augmenta- tion Julie Lyng Forman Thomas Jensen (Department of Oral Surgery, Aarhus University Hospital, Aalborg Hospital, Aalborg, Denmark)

Treatment of deformational plagiocephaly Lene Theil Skovgaard Tron Darvann (3D Craniofacial Image Research Laboratory,Copenhagen University Hospital, Copenhagen, Denmark)

Pulp ﬁction: Developing an online risk calculator for traumatology in dentistry Thomas Alexander Gerds Jens Andreasen (Department of Oral and Maxillofacial Surgery, Copenhagen Univer- sity Hospital, Copenhagen, Denmark), Eva Lauridsen (Resource Center for Rare Oral Diseases, University Hospital of Copenhagen, Copenhagen, Denmark), Søren Steno (Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital,, Copenhagen, Denmark)

Analysis of the development stage of wisdom teeth Thomas Alexander Gerds Søren Rødsgaard (Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital, Copenhagen, Denmark)

29 Applied statistical collaborations

Pediatry Mortality of children born premature: A Scandinavian study Julie Lyng Forman Rene Mathiasen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen- hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark)

Disease course diﬀerences between children and adults in inﬂammatory bowel disease Randi Grøn, Thomas Alexander Gerds Anders Pærregaard (Pediatric Department, Hvidovre University Hospital, Hvidovre, Denmark), Christian Jacobsen (Pediatric Department, Hvidovre University Hospital, Hvidovre, Denmark), Jiri Bartek (Hvidovre Hospital, Hvidovre, Denmark)

Cognitive performance of children with Tourette syndrome Theis Lange Nanette Mol Debes (Pediatric Department, Glostrup University Hospital, Glostrup, Denmark), Liselotte Skov (Pediatric Department, Glostrup University Hospital, Glostrup, Denmark)

Pesticide Pesticide use and symptoms of poisoning Jørgen Holm Petersen Hanne Klith Jensen (Department of Veterinary Disease Biology/Section for Microbi- ology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark)

Psychiatry A register-based study of anti-psychotic treatment and risk of diabetes Per Kragh Andersen, Ulla Brasch Mogensen Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Anders Frøkjær Thomsen (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

A register-based study on the eﬀect of antidepressants and mood stabiliz- ing medicine on the onset of dementia Julie Lyng Forman, Per Kragh Andersen Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Lars Søndergaard (Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark)

30 Applied statistical collaborations

Psycho-social health of children born premature in Denmark 1974-1996 Julie Lyng Forman Rene Mathiasen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen- hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Eﬀect of antidepressant medicine and depression during pregnancy Randi Grøn, Per Kragh Andersen Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Øjvind Lidegaard (Gynecologic Clinic, Copenhagen Uni- versity Hospital, Copenhagen, Denmark), Lars Henning Pedersen (School of Public Health, Aarhus University, Aarhus, Denmark), Ellen Margrethe Christensen (Depart- ment of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Hans Mørch Jensen (Psykiatrisk Center Bispebjerg, Copenhagen, Denmark)

Assortative mating Maja Olsbjerg Larsen, Per Kragh Andersen Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Anders Frøkjær Thomsen (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Prescription of anti-psychotics with or without prior psychiatric contacts Per Kragh Andersen, Gunnar Hellmund Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Bio-characterization of depressive patients and their relatives Jørgen Hilden Ulla Knorr (Center of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark)

Respiratory diseases Two compartment model for ﬂow rate data of COPD patients Thomas Alexander Gerds, Esben Budtz-Jørgensen Nassim Bazeghi Roberts (GlaxoSmithKline, Copenhagen, Denmark), Jørgen Vestbo (University of Manchester, North West Lung Research Centre, University Hospital of South Manchester Foundation Trust, Manchester, England)

31 Applied statistical collaborations

Sports medicine Eﬀect of a training program on hamstring injuries in football Esben Budtz-Jørgensen Jesper Petersen (Microarray Technology Group, Department of Micro and Nanotech- nology, Technical University of Denmark, Lyngby, Denmark), Kristian Thorborg (Department of Orthopaedic Surgery, Amager Hospital., Copenhagen, Denmark), Michael Bachmann Nielsen (Department of Radiology, Section of Ultrasound, Diag- nostic Centre, Rigshospitalet., Copenhagen, Denmark), Per H¨olmich (Department of Orthopaedic Surgery, Amager Hospital., Copenhagen, Denmark)

Tomography Features of strut apposition after coronary stent implantation Lene Theil Skovgaard, Sara Brebbia Maria Radu (Cardiologic Laboratory, Copenhagen University Hospital, Copenhagen, Denmark)

3.2 Epidemiology Diabetes Insulin-resistance and chronic low-grade inflammation Karl Bang Christensen, Kira Dynnes Svendsen Sofie Andreasen (The Centre of Inflammation and Metabolism, Copenhagen Univer- sity Hospital, Copenhagen, Denmark)

32 Applied statistical collaborations

Environmental epidemiology Air pollution, Methods for assessing the eﬀects of air pollution on urgent hospital admission Thomas Alexander Gerds, Sara Brebbia, Jens Flachs Janine Wichmann (School of Health Systems and Public Health, Health Sciences Faculty, University of Pretoria, Pretoria, South Africa), Zorana Jovanovic Andersen (Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark), Steﬀen Loft (Section of Environmental Health, Department of Public Health, Univer- sity of Copenhagen, Copenhagen, Denmark)

An international pooled analysis for obtaining a Benchmark dose for exposure to lead Esben Budtz-Jørgensen Bruce Lanphear (Cincinnati Children’s Environmental Health Center, Department of Pediatrics and of Environmental Health, Cincinnati, USA), David Bellinger (Department of Neurology, Children’s Hospital Boston and Harvard Medical School, Boston, USA), Philippe Grandjean (Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Environmental epidemiology Esben Budtz-Jørgensen Philippe Grandjean (Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Epidemiology and social medicine Social Diﬀerences in Specialized care Jørgen Holm Petersen Pernille Due (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark)

Bereavement and risk of ischaemic heart disease Per Kragh Andersen Margit Kriegbaum (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

Social inequalities in headache among adolescents Per Kragh Andersen Christina Schnohr (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

33 Applied statistical collaborations

Preventive child health care at general practitioner and social diﬀerences in the use of specialized care Jørgen Holm Petersen Solvej M˚artensson(Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark), Pernille Due (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark)

Familial aggregation of deep venous thrombosis Lars Jorge Diaz, Per Kragh Andersen Henrik Toft Sørensen (Clinical Epidemiology, Aarhus University, Aarhus, Denmark)

Physical exercise as a risk factor for fetal death Per Kragh Andersen Mette Juhl (National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark)

Socio-economic position and risk of preterm birth Per Kragh Andersen Camilla Morgen (National Institute of Public Health, University of Southern Den- mark, Copenhagen, Denmark)

34 Applied statistical collaborations

Genetic epidemiology LuCamp: Lundbeck Foundation Centre for Applied Medical Genomics in Personalised Disease Prediction, Prevention and Care. Anders Albrechtsen Oluf Pedersen (Steno Diabetes Center, Gentofte, Denmark), Torben Hansen (Techni- cal University of Denmark, Lyngby, Denmark), Jun Wang (Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan), Knut Borch Johnsen (Steno Diabetes Center, Gentofte, Den- mark), Gitte Andersen (Steno Diabetes Center, Gentofte, Denmark), Lars Bolund (Department of Human Genetics, University of Aarhus, Aarhus, Denmark), Ole Schmitz (Department of Diabetes, University Hospital of Aarhus, Aarhus, Denmark), Torsten Lauritzen (Department of General Practice, Institute of Public Health, Uni- versity of Aarhus, Aarhus, Denmark), Karsten Kristiansen (Department of Biology, University of Copenhagen, Copenhagen, Denmark), Torben Jørgensen (Research Centre for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark), Arne Astrup (Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark), Thue Schwartz (Laboratory for Molecular Pharmacology, Institute of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark), Rasmus Nielsen (Department of Biology, University of Copenhagen, Copenhagen, Denmark)

Pubertal Onset in Boys and the Growth Hormone Receptor Exon 3 Gene Deletion Jørgen Holm Petersen Kaspar Sørensen (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Twin study about heritability of heart function Esben Budtz-Jørgensen Christian Haarmark Nielsen (Laboratory of Experimental Cardiology, University of Copenhagen, Copenhagen, Denmark), Jørgen K. Kanters (Laboratory of Experimen- tal Cardiology, University of Copenhagen, Copenhagen, Denmark), Kirsten O. Kyvik (The Danish Twin Registry, University of Southern Denmark, Odense, Denmark)

Education and morbidity/mortality in twins Per Kragh Andersen Mia Madsen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Genetic prevalence of mutant genes related to malaria Lene Theil Skovgaard Helle Holm Hansson (Department of International Health, Immunology and Microbi- ology, University of Copenhagen, Copenhagen, Denmark)

35 Applied statistical collaborations

Growth and reproduction Reference levels for AMH Jørgen Holm Petersen Anders Juul (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Survey in France of time to pregnancy Niels Keiding, Oluf Kristian Højbjerg Hansen Rémy Slama (Institut national de la santéet de la recherchémédicale,University J Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Grenoble, France), Jean Bouyer (Inserm, National Institute of Health and Medical Research, U569, Paris, France)

Timing of menarche and estimation of heritability based on the twin- registry Thomas Scheike Anders Juul (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark), Tina Kold Jensen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark), Kaspar Sørensen (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Time to pregnancy Thomas Scheike Tina Kold Jensen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark)

Thyroid hormones during normal pregnancies Julie Lyng Forman, Jørgen Holm Petersen Malene Boas (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark), Katharina Main (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Human nutrition Determinants for vitamin D level Lene Theil Skovgaard Rikke Andersen (Department of Nutrition, National Food Institute, Technical University, Søborg, Denmark)

Evaluation of a nutritional program for children in Ethiopia Lene Theil Skovgaard Jutta Skau (Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark)

36 Applied statistical collaborations

Immunology Chronic lymphocytic leukæmia and autoimmunity Jørgen Hilden Viggo Jønsson (Division of Hematology, Aker University Hospital, University of Oslo, Oslo, Norway)

Malaria research Risk Factors and Spatial Variation in Malaria in Area of Diﬀerent Trans- mission Intensities in Northeastern Tanzania Bruno Paul Mmbando, Thomas Scheike Thor Theander (Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark)

Consequences of pregnancy-associated malaria on fetal growth Thomas Scheike Thor Theander (Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark), Christentze Schmiegelow

Mediation analysis Poor sleep quality and mortality: Is the relation mediated by diabetes, weight changes, and/or hypertension? Theis Lange Naja Hulvej Rod (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

37 Applied statistical collaborations

Neuroimaging Examination of seasonal variation in plasma membrane serotonin transporter measured by PET-scans Esben Budtz-Jørgensen, Klaus K¨ahlerHolst Gitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark)

Association between response to pain and 5-HT2A receptor binding in the human brain Esben Budtz-Jørgensen Ron Kupers (Department of Clinical Physiology and Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen, Denmark), Gitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark), Vibe Frøkjær (Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Copenhagen, Denmark)

Genetic predictors of brain serotonin 2A receptor binding Esben Budtz-Jørgensen, Klaus K¨ahlerHolst Gitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark)

Using structural equation models to describe the variation in PET-data Esben Budtz-Jørgensen, Klaus K¨ahlerHolst Gitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark)

Obesity Overweight among children in Greenland Jørgen Holm Petersen Christina Schnohr (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

38 Applied statistical collaborations

Occupational epidemiology Occupational exposure to the sun and risk of skin and lip cancer among male wage earners Esben Budtz-Jørgensen Line Kenborg (Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark), Ane Dahl Jørgensen (Institute of Cancer Epidemiology, Danish Cancer So- ciety, Copenhagen, Denmark), Lisbeth E Knudsen (Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark), Johnni Hansen (Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark)

Occupational medicine Factors of importance for sickness absence Signe Jensen, Svend Kreiner, Nina Breinegaard Sigurd Mikkelsen (Department of Occupational Medicine, Glostrup University Hospital, Glostrup, Denmark)

Work environment Risk factors for disability pension Karl Bang Christensen Helene Feveile (The National Research Centre for the Working Environment, Copen- hagen, Denmark)

Noise exposure as a risk factor for long-term sickness absence Karl Bang Christensen Thomas Clausen (National Research Centre for the Working Environment, Copen- hagen, Denmark)

3.3 Public health Health Economics Quality of life adjusted survival after myocardial infarction Per Kragh Andersen, Kira Dynnes Svendsen Anne Hvenegaard (Danish Institute for Health Services Research, Copenhagen, Denmark), Jes Søgaard (Danish Institute for Health Services Research, Copenhagen, Denmark)

39 Applied statistical collaborations

Health services research Eﬀect of ethnic background on Danish health care utilisation patterns Niels Keiding, Ana Garcia Lopez Marie Nørredam (Section for Health Services Research, Department of Public Health, University of Copenhagen, Copenhagen, Denmark), Allan Krasnik (Section for Health Services Research, University of Copenhagen, Copenhagen, Denmark)

3.4 Statistical genetics Growth and reproduction Genetic factors behind male infertility Jeremy Silver, Thomas Alexander Gerds Henrik Leﬀers (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark), Ramneek Gupta (Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark)

Statistical genetics Association studies for major depressive disorder using SNP chip data Anders Albrechtsen, Peter Dalgaard Thomas Hansen (Department of Chemistry, Centre for Catalysis and Sustainable Chemistry, Technical University of Denmark, Lyngby, Denmark), Ulrik Gether (Molecular Neuropharmacology Group, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark), Thomas Werge (Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark)

Relatedness and linkage analysis using 500k Aﬀymetrix data Anders Albrechtsen Finn Cilius Nielsen (Bioinformatics Centre, University of Copenhagen, Copenhagen, Denmark), Thomas van Overeem Hansen (Department of Chemistry, Centre for Catalysis and Sustainable Chemistry, Technical University of Denmark, Lyngby, Denmark)

Darwinian and demographic forces aﬀecting human protein coding genes Anders Albrechtsen Rasmus Nielsen (Department of Biology, University of Copenhagen, Copenhagen, Denmark), Ines Hellmann (Departments of Integrative Biology and Statistics, University of California, Berkeley, USA)

40 Statistical software development

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Anders Albrechtsen

Genetic and environmental eﬀects in infectious diseases Per Kragh Andersen Liselotte Petersen (Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark)

Prevention of von Hippel-Lindaus disease Esben Budtz-Jørgensen Marie-Louise Bisgaard (Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark), Marie Louise Poulsen (Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark)

4 Statistical software development Digram: a program for analysis of ordinal categorical data Svend Kreiner

Timereg R package : Extensive R package of programs for estimation of advanced modern survival models Thomas Scheike

MultiComp : R package for modelling of dependence for multivariate competing risks data. Thomas Scheike Yanqing Sun (Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, USA)

Prediction error curves: R package to compare survival prediction modelling strategies. Thomas Alexander Gerds

HaploSurvival : R-package for haplotype eﬀects in survival and competing risks data Thomas Scheike, Jeremy Silver

R-package for the product-limit method in event history models Thomas Alexander Gerds

Development of residual-based goodness-of-ﬁt tests in R Klaus K¨ahlerHolst

41 Core facility

Development of Latent Variable Modelling framework in R Klaus K¨ahlerHolst

Implementation of IRT models in SAS Karl Bang Christensen, Maja Olsbjerg Larsen

AssoF, AssoG: R package generator for association studies. Anders Albrechtsen Torben Hansen (Technical University of Denmark, Lyngby, Denmark), Niels Grarup (Steno Diabetes Center, Gentofte, Denmark), Thomas Sparsø(Steno Diabetes Center, Gentofte, Denmark), Oluf Pedersen (Steno Diabetes Center, Gentofte, Denmark), Camilla Andersen (Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Copenhagen, Denmark)

5 Core facility

The Faculty of Health Sciences has created a Core Facility in Biostatistics led by Niels Keiding. The Core Facility started in 2007 and will run until 2011. The purpose of the Core Facility is to conduct independent biostatistical research as well as assisting the Cluster of Fetal Environmental and Postnatal Disease (lead by Professor Anders Juul, Department of Growth and Reproduction, Rigshospitalet) and the Post-Genomic Public Health Cluster - GENPUB (lead by Professor Steﬀen Loft, Department of Environmental Health, Institute of Public Health) with biostatistical tasks. In 2009, the following people were fully or partly ﬁnanced by the Core Facility: Thomas Scheike, Thomas Alexander Gerds, Jørgen Holm Petersen, Julie Lyng Forman, and Sara Brebbia. In 2009, part of the work of these people was directly connected to the Core Facility in Biostatistics.

5.1 Core Facility: Projects In 2009, the following projects were directly associated to the Core Facility of Bio- statistics1:

Reference levels for AMH Jørgen Holm Petersen Anders Juul (Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Overweight among children in Greenland Jørgen Holm Petersen Christina Schnohr (Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark)

1Note, that the same projects are also listed in the previous subsections

42 Core facility

Risk charts predicting ovarian response Thomas Alexander Gerds, Julie Lyng Forman, Jeremy Silver Nina La Cour Freiesleben (The Fertility Clinic, The Juliane Marie Center, Copen- hagen University Hospital, Copenhagen, Denmark), Anders Nyboe Andersen (Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark)

Methods for constructing age-speciﬁc 2-dimensional reference charts for reproductive hormones Jørgen Holm Petersen

Modelling microarray and metabolite data to improve the diagnosis of inﬂammatory bowel disease patients Thomas Alexander Gerds, Ulla Brasch Mogensen Jørgen Olsen (Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark), Morten Hansen (Department of Cardiology, Bispebjerg University Hospital, Bispebjerg, Denmark)

Describing association for competing risks data Thomas Scheike Yanqing Sun (Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, USA)

43 Core facility

Heritability for survival data Klaus K¨ahlerHolst, Jørgen Holm Petersen, Thomas Scheike

44 Core facility

Mortality of children born premature: A Scandinavian study Julie Lyng Forman Rene Mathiasen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen- hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, Copenhagen University Hospital, Copenhagen, Denmark)

Time to pregnancy Thomas Scheike Tina Kold Jensen (Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark)

5.2 Core Facility: Publications In 2009, the following publications were associated to the Core Facility in Biostatis- tics2:

Boas M, Forman JL, Juul A, Feldt-Rasmussen U, Skakkebæk NE, Chellakooty M, Larsen T, Falck Larsen J, Petersen JH & Main KM (2009) Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study of 132 women European Journal of Endocrinology 161 903-910.

Petersen JH (2009) A non-parametric conditional bivariate reference region with an application to height/weight measurements on normal girls Biometrical Journal 51 (4) 697-709.

Olsen J, Gerds TA, Seidelin JB, Csillag C, Bjerrum JT, Troelsen JT & Nielsen OH (2009) Diagnosis of ulcerative colitis before onset of inﬂammation by multivariate modeling of genome-wide gene expression data Inﬂammatory Bowel Diseases 15 (7) 1032-1038.

Joﬀe M, Key J, Best N, Jensen TK & Keiding N (2009) The role of biological fertility in predicting family size Human Reproduction 24 (8) 1999-2006.

Key J, Best N, Joﬀe M, Jensen TK & Keiding N (2009) Methodological issues in analyzing time trends in biologic fertility: Protection bias American Journal of Epidemiology 169 (3) 285-293.

Pers TH, Albrechtsen A, Holst C, Sørensen TIA & Gerds TA (2009) The validation and assessment of machine learning: A game of prediction from high-dimensional data PLoS ONE 4 (8) e6287.

Teilmann G, Petersen JH, Gormsen M, Damgaard K, Skakkebæk NE & Jensen TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years Hormone Research 72 (4) 236-246.

2The same publications are also listed later on in chapter Publications

45 Core facility

Bang AK, Petersen JH, Petersen PM, Andersson A, Daugaard G & Jørgensen N (2009) Testosterone production is better preserved after 16 than 20 Gray irradiation treatment against testicular carcinoma in situ cells International Journal of Radiation: Oncology - Biology - Physics 75 (3) 672-676.

Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen JH, Hilsted L, Helge JW & Juul A (2009) Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty Diabetes Care 32 (5) 909-914.

Aksglaede L, Sørensen K, Petersen JH, Skakkebæk NE & Juul A (2009) Recent decline in age at breast development: The Copenhagen Puberty Study Pediatrics Electronic Pages 123 (5) 932-939.

46 Statistical community

1 Advisory and journal activities

Members of the staﬀ are actively engaged in editorial work and various activities that are beneﬁcial for statistical society.

Esben Budtz-Jørgensen

• Statistical Advisor - Environmental Health

• Member of ISI- Committee on Risk Analysis

• PhD committee Mette Gerster (Department of Biostatistics)

Jørgen Holm Petersen

• Associate Editor (Biometrical Journal)

Niels Keiding

• Advisory board (Biostatistics)

• Editorial Board (Chapman & Halls Monographs in Statistics)

• Editorial Board (Chapman & Hall Interdisciplinary Statistics Series)

• Member of advisory board, Linnaeus project ’Ageing and living conditions’ (Uni- versity of Ume˚a)

• Member of steering committee, Evaluation of mammography screening (Norwe- gian Research Council)

47 Advisory and journal activities

Per Kragh Andersen

• Associate Editor (Statistical Methods in Medical Research)

• Associate Editor (Biometrics)

• Associate Editor (Lifetime Data Analysis)

Peter Dalgaard

• Member (The R Foundation for Statistical Software)

Thomas Alexander Gerds

• Associate Editor (Biometrical Journal)

Thomas Scheike

• Associate Editor (Journal of the Royal Statistical Society Series B)

• Associate editor (Lifetime Data Analysis)

• Member of the Research Section (The Royal Statistical Society)

48 International collaboration

2 International collaboration

The department has many international contacts, both through international visitors here and through our own study leaves abroad and participation in international con- ferences. This section lists guests and seminars, as well as talks and travels of the scientiﬁc staﬀ.

2.1 Visitors March Michael Kattan (Quantitative Health Sciences, Cleveland Clinic, Ohio, USA)

Thomas Lumley (Department of Biostatistics, University of Washington, Seattle, USA)

May Kyle Raymond (University of Waterloo, Ontario, Canada)

Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Jessica Kasza (University of Adelaide, Adelaide, Australia)

June Anthony J. McMichael (National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia)

Halina Frydman (Stern School of Business, New York University, New York, USA)

Bastian Mengelle (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes, France)

Yacine el Bouhairi (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes, France)

Stijn Vansteelandt (Department of Applied Mathematics and Computer Science, University of Ghent, Belgium)

Yanqing Sun (Department of Mathematics and Statistics, University of North Carolina at Charlotte)

49 International collaboration

Victor Panaretos (Institute of Mathematics, Ecole Polytechnique F´ed´erale de Lausanne)

July Yacine el Bouhairi (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes, France)

Bastian Mengelle (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes, France)

Martin M¨achler (Swiss Federal Institute of Technology Z¨urich,Switzerland)

John Chambers (Stanford University, California, USA)

Deepayan Sarkar (Fred Hutchinson Cancer Research Center, Seattle, USA)

Simon Urbanek (AT+T Labs, New Jersey, USA)

Luke Tierney (University of Iowa, Iowa City, USA)

Jonas Abrahamsson (Department of Pediatrics, Queen Silvia Children’s Hospital, G¨oteborg, Sweden)

Uwe Ligges (University of Dortmund, Germany)

Doug Bates (University of Wisconsin, Madison, Wisconsin, USA)

August Knut Liestøl (University of Oslo, Norway)

Roger Bivand (Norwegian School of Economics and Business Administration, Bergen, Norway)

Ørnulf Borgan (University of Oslo, Norway)

Martyn Plummer (International Agency for Research on Cancer, Lyon, France)

50 International collaboration

September Vladimir Canudas-Romo (Johns Hopkins University, Baltimore, USA)

Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Øystein Kravdal (Department of Economics, University of Oslo, Oslo, Norway)

Aurelien Latouche (Universit´eVersailles St. Quentin, Versailles, France)

October James Carpenter (London School of Hygiene and Tropical Medicine, London, England)

November Vanessa Didelez (University of Bristol, Bristol, England)

Mounir Mesbah (Universit´ePierre et Marie Curie, Paris, France)

Bianca de Stavola (London School of Hygiene and Tropical Medicine, London, England)

2.2 Seminar The following researchers presented at the department:

26 January 2009 Umberto Picchini Department of Mathematical Sciences, University of Copenhagen Random parameters in stochastic diﬀerential equation models with applications

16 March 2009 Michael Kattan Quantitative Health Sciences, Cleveland Clinic Encouraging the Use of Statistical Prediction Models

31 March 2009 Thomas Lumley Department of Biostatistics, University of Washington, Seattle Case-crossover and other case-distribution designs

51 International collaboration

20 April 2009 Karl Bang Christensen Department of Biostatistics, University of Copenhagen Monte Carlo tests of the Rasch model based on scalability coeﬃcients. Joint work with Svend Kreiner

18 May 2009 Ole Winther Intelligent Signal Processing, Informatics and Mathematical Modelling, Technical University of Denmark Bayesian networks and graphical models with machine learning applications

8 June 2009 Yanqing Sun Department of Mathematics and Statistics, University of North Carolina at Charlotte Empirical likelihood inference for the Cox model with time-dependent coeﬃcients via local partial likelihood

15 June 2009 Victor Panaretos Institute of Mathematics, Ecole Polytechnique F´ed´erale de Lausanne Second-Order Functional Comparison of DNA Minicircles.

25 June 2009 Stijn Vansteelandt Department of Applied Mathematics and Computer Science Ghent University Adjusting for time-varying confounding in survival analysis with competing risks

17 August 2009 Martyn Plummer Infection and Cancer Epidemiology (ICE) group, International Agency for Research on Cancer, Lyon Bayesian hierarchical modelling with JAGS

28 September 2009 Aurelien Latouche Universit´eVersailles St-Quentin, France A Regression Model for the Conditional Cumulative Incidence Function

2 November 2009 Bendix Carstensen Steno Diabetes Center, Gentofte & Department of Biostatistics, University of Copenhagen Practical aspects of multistate modelling: Representation, timescales and prediction

19 November 2009 Bianca De Stavola London School of Hygiene and Tropical Medicine Familial and socio-economic inﬂuences on foetal growth across three generations: The Uppsala Birth Cohort Multigenerational study, Sweden, 1915-2002

52 External presentations of members of the department

3 External presentations of members of the department 3.1 Talks Anders Albrechtsen Bayesian association studies, allowing for higher order interaction in association studies ENAR, Spring Meeting with IMS and Sections of ASA San Antonio, Texas, USA

Per Kragh Andersen Applications of counting processes in epidemiology Universite Bordeaux 2 Biological interaction from a statistical point of view 2nd Channel Network Conference of the IBS Gent, Belgien Multi-state models and models for competing risks Erasmus MC Rotterdam, Holland Follow-up studies European Educational Programme in Epidemiology Firenze, Italy Event dependent sampling of recurrent events ISCB ISCB, Prague, Czech Republic The inﬂuence of Cox’s article about regression models and life-tables International Conference of the Royal Statistical Society Edinburgh, Scotland Competing risks and time-dependent covariates DSTS todagesmøde, SDU Odense Recurrent events in psychiatric epidemiology 9th Galician congress on statistics and operations research Ourence, Spanien Biological interaction from a statistical point of view Workshop on mediation and interaction Schæﬀerg˚arden,Gentofte, Denmark

Esben Budtz-Jørgensen Joint analysis data from two cohort studies on the health eﬀects of prenatal exposures to mercury and PCB Thorshavn

53 External presentations of members of the department

Diﬀerent approaches to model averaging in environmental risk assessment International Conference of the Royal Statistical Society Edinburgh, Scotland Approaches to handling uncertainty when setting environmental exposure standards University of Southern Denmark An international pooled analysis for obtaining a benchmark dose for environmental lead exposure in children pptoxII (conference) Miami, USA.

Peter Dalgaard Ideas about likelihood-based data analysis in R Statistisk stjerneforskernetværk Jørlunde Everything you ever wanted to know about R (almost) DTU Informatics, Sect. f. Scientiﬁc Computing Strengths and weaknesses of the R language for statistical computing Invited paper session IMST 2009, Plzen, Czech Republic Ideas about likelihood-based data analysis in R Directions in Statistical Computing (DSC) Copenhagen, Denmark Ideas about likelihood-based data analysis in R 2nd Nordic-Baltic Biometric Conference Tartu, Estland What we wish people knew more about when working with R useR, Invited Lecture Rennes, France

Julie Lyng Forman The Pearson diﬀusions: Statistically tractable diﬀusions Joint Statistical Meeting 2009 Washington DC

Thomas Alexander Gerds The statistical evaluation of risk prediction models INSERM, Epidemiology and Biostatistics Research Center, Bordeaux, France Random survival forests in action Statistisches Kolloquium Heinrich-Heine University, D¨usseldorf,Germany

54 External presentations of members of the department

Gunnar Hellmund Statistical analysis of FLIM data Workshop Department of Mathematical Science, University of Aarhus

Jørgen Hilden Borrelia diagnostics - statistical aspects Nordiske Borreliadage Oren¨asSlott,¨ Sk˚ane,Sweden

Klaus Kahler¨ Holst An R package for structural equation modeling Statistisk stjerneforskernetværk Jørlunde Non-linear structural equation models with applications in Neuroimaging Joint Statistical Meeting 2009 Washington DC

Niels Keiding Estimation of time-to-pregnancy from current duration data Statistisk stjerneforskernetværk Jørlunde Har peer review stadig en chance? Arsmøde˚ i Nationalkomiteen for Videnskabsﬁlosoﬁ Niels Bohr Instituttet Design and analysis of time-to-pregnancy studies Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden Talk with panel discussion Causal inference: State-of-the-Art University of Cambridge Kan man forudsige den enkelte patients restlevetid? Institutkonference Kollekolle Event history analysis and the cross-section Department of Statistics, University of Chicago Greenberg Lecture Series, part I: A Event history analysis and the cross section. B Design and analysis of time-to-pregnancy - Classical approaches. Greenberg Lecture Series Department of Biostatistics, University of North Carolina at Chapel Hill, North Car- olina

55 External presentations of members of the department

Greenberg Lecture Series, part II: A Design and analysis of time-to-pregnancy - Current duration data. B Pharmacoepidemiology: prescription registries and cross- sectional surveys Greenberg Lecture Series Department of Biostatistics, University of North Carolina at Chapel Hill, North Car- olina Rates of births and induced abortions in Denmark according to age, previous births, and previous abortions 57th Session of the ISI Durban, South Africa (via e-link) Biostatisticians - the Danish model: the challenge of using both cerebral hemispheres Leiden University The role of study design in the evaluation of health eﬀects of postmenopausal hormone therapy Workshop on Causal Modelling Oslo Estimation of time-to-pregnancy from current duration data MRC Biostatistics Unit Cambridge Analysis of time-to-pregnancy MRC Centre for Causal Analyses in Translational Epidemiology Department of Social Medicine, University of Bristol, England

Theis Lange Mediation in Survival Analysis DSTS todagesmøde, University of Southern Denmark Odense

Ulla Brasch Mogensen Survival paths through the forest Statistisk stjerneforskernetværk Jørlunde Application of random survival forests based on pseudo-values ISCB ISCB, Prague, Czech Republic

Lisbeth Nørgaard Møller Determinants for GP visits in a primary intervention setting Forskningens Dag Glostrup Hospital

56 External presentations of members of the department

Janne Petersen Latent Class Predictions for Subsequent Analysis Joint statistical meeting Washington

Jørgen Holm Petersen Løgn og Statistik Hvidovre Hospital

Thomas Scheike Time-to-pregnancy as measure of biological fecundity: design problems and relation to semen quality Postgraduate Course Copenhagen University Hospital Competing risks with missing covariates: Eﬀect on haplotype match on BMT patients Joint Statistical Meeting 2009 Washington DC, USA Estimation of haplotype eﬀects for survival data DSTS todagesmøde, University of Southern Denmark Odense, Denmark

3.2 Travels Per Kragh Andersen January Universite Bordeaux 2, Marseille, France

July Firenze, Italy (European Educational Programme in Epidemiology)

September Edinburgh, Scotland

September Prague, Czech Republic (ISCB)

November Universida de Vigo, Spain

Nina Breinegaard August Prague, Czech Republic (ISCB conference)

57 External presentations of members of the department

September Universit´eCatholique de Louvain, Louvain-la-Neuve, Belgium (Course)

Esben Budtz-Jørgensen April Amsterdam, The Netherlands (EFSA, Expert Committee on the BMD approach)

September Thorshavn, The Faroe Islands

September Edinburgh, Scotland (International Conference of the Royal Statistical Society)

December Miami, USA. (pptoxII (conference))

Karl Bang Christensen August Bled, Slovenia (Invited International Rasch Measurement Workshop)

Peter Dalgaard June Tartu, Estland (2nd Nordic-Baltic Biometric Conference)

July Rennes, France (useR! The R User Conference)

Julie Lyng Forman September Washington DC, USA (JSM)

Randi Grøn June Erasmus MC, Rotterdam, The Netherlands (Course on multistate models and competing risks)

September Prague, Czech Republic (ISCB)

Klaus Kahler¨ Holst September Washington DC, USA (JSM)

58 External presentations of members of the department

Niels Keiding February Ageing and living conditions, University of Ume˚a

February Department of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm

March Statistical Laboratory, Centre for Mathematical Science, Cambridge, England (Causal inference: State-of-the-Art)

April Department of Statistics, University of Chicago

April Norges Forskningsr˚ad,Norway

April – May Population Association of America, Detroit, USA

May Observatoire Epidemiologique de la fertilit´een France, St. Francois de Sales, France

May Department of Biostatistics, University of North Carolina

August Leiden University, The Netherlands (Vision on Statistical Science)

September Workshop on Causal Modelling, Oslo

September – November MRC Biostatistics Unit, Cambridge

November MRC Centre for Causal Analyses in Translational Epidemiology (Department of Social Medicine, University of Bristol, England)

Svend Kreiner June Bled, Slovenia (Invited International Rasch Measurement Workshop)

Ulla Brasch Mogensen September ISCB, Prague, Czech Republic (ISCB)

59 External presentations of members of the department

Lisbeth Nørgaard Møller March Statistical Laboratory, Centre for Mathematical Science, Cambridge, England (Causal inference: State-of-the-Art)

Susanne Rosthøj August Prague, Czech Republic (ISCB)

September – November Oslo, Norway (Workshop on Causal Modelling)

Thomas Scheike March G¨oteborg, Sverige (Annual meeting of the European group for blood and marrow transplantation)

August Washington DC, USA (Joint Statistical Meeting 2009)

Lene Theil Skovgaard September ISCB, Prague (ISCB)

60 Teaching

1 Courses

The department oﬀers basic statistic courses to students in health science and specialized courses to Ph.D. students. In 2009, the department oﬀered the following courses.

1.1 Ph.D. courses Introduction to SPSS (Spring) Organized by Svend Kreiner

The R statistical environment (Spring) Organized by Peter Dalgaard

Statistical analysis of survival data (Spring) Organized by Thomas Scheike

Statistical evaluation of diagnostic and predictive models (Spring) Organized by Thomas Alexander Gerds

Basic statistics for health researchers (Spring) Organized by Lene Theil Skovgaard

Validation of Scales (Spring) Organized by Svend Kreiner

Epidemiology (Spring) Organized by Per Kragh Andersen

Analysis of variance and regression for health researchers (Spring) Organized by Peter Dalgaard

Use of SAS statistical software (Spring) Organized by Esben Budtz-Jørgensen

Structural equation modeling (Fall) Organized by Esben Budtz-Jørgensen

Basic statistics for health researchers (Fall) Organized by Lene Theil Skovgaard

61 Supervision

Basic statistics for health researchers from foreign countries (Fall) Organized by Thomas Alexander Gerds

Use of SAS statistical software (Fall) Organized by Esben Budtz-Jørgensen

Advanced statistical analysis of epidemiological studies (Fall) Organized by Per Kragh Andersen

Introduction to SPSS (Fall) Organized by Svend Kreiner

Analysis of variance and regression for health researchers (Fall) Organized by Lene Theil Skovgaard

1.2 Master / Bachelor courses Demography (Public Health) (Spring) Organized by Niels Keiding

Statistical methods (IT and Health) (Fall) Organized by Peter Dalgaard

Statistics 1.sem. (Master of Health Science) (Fall) Organized by Karl Bang Christensen

Statistics and data analysis for human biologists (Fall) Organized by Thomas Alexander Gerds

Demography (Public Health) (Fall) Organized by Esben Budtz-Jørgensen

Statistics (Medicine) (Fall) Organized by Thomas Scheike

Compulsory module 1 Statistics and epidemiology (Master of Public Health) (Fall) Organized by Per Kragh Andersen

Statistics (Odontology) (Fall) Organized by Thomas Scheike

Statistics (Public Health) (Fall) Organized by Jørgen Holm Petersen

2 Supervision

This section lists Ph.D. projects in biostatistics and Ph.D. students in other main disciplines (co-supervision).

62 Supervision

Esben Budtz-Jørgensen Janne Petersen Definition of syndromes by latent variables: HIV-associated lipodystrophy syndrome Klaus KählerHolst Development of statistical methods for estimation of genetic effects on brain function- ing measured through PET and FMRI images.

Karl Bang Christensen Kirstine Magtengaard Robinson Diagnostic delay among gynecological cancer patients

Niels Keiding Lars Hougaard Nielsen Pharmacoepidemiological methodology for prescription registries Mette Gerster Uddannelse og fertilitet Susanne Rosthøj Feedback mechanisms in dosing strategies in child oncology Ulla Hvidtfeldt Mediation of socio-economic gradients

Svend Kreiner Christina Warrer Schnohr Measuring and understanding social inequalities in adolescent smoking Lisbeth Nørgaard Møller Methods for estimating direct eﬀects of repeated interventions

Thomas Alexander Gerds Randi Grøn Accurate conﬁdence limits for misspeciﬁed models with applications to longitudinal data. Ulla Brasch Mogensen Survival paths through the random forest

Thomas Scheike Anders Gorst Rasmussen Model selection and high-dimensional covariates for survival data Bruno Paul Mmbando Malaria in Tanzania

63 Supervision

Jacob Simonsen Sero epidemiology Kyle Raymond Haplotype eﬀects for competing risks data Nina Gros Pedersen Growth based on ultra-sound measurements

64 Publications

3 Publications

The publications are listed in the following categories according to the research ﬁeld:Statistics, Demography, Dentistry, Epidemiology, Genetics, Mathematics, Medicine, Natural science, Psychiatry, Public Health, Sociology. Books, articles in books and articles in proceedings, as well as PhD thesis are listed separately.

3.1 Journal articles Statistics Aalen OO, Andersen PK, Borgan Ø, Gill RD & Keiding N (2009) History of applications of martingales in survival analysis Journal Electronique´ d’Histoire des Probabililt´eset de la Statistique 5 Epub.

Dalgaard P (2009) Can we have better semantics for R’s attach mechanism? Computational Statistics 24 263-269.

Graw F, Gerds TA & Schumacher M (2009) On pseudo-values for regression analysis in competing risks models Lifetime Data Analysis 15 (2) 241-255.

Martinussen T & Scheike T (2009) The additive hazards model with high-dimensional regressors Lifetime Data Analysis 15 (3) 330-42.

Martinussen T & Scheike T (2009) Covariate selection for the semiparametric additive risk model Scandinavian Journal of Statistics 36 (4) 602-619.

Petersen JH (2009) A non-parametric conditional bivariate reference region with an application to height/weight measurements on normal girls Biometrical Journal 51 (4) 697-709.

Sanchez BN, Budtz-Jørgensen E & Ryan LM (2009) An estimating equations approach to ﬁtting latent exposure models with longitudinal health outcomes Annals of Applied Statis- tics 3 (2) 830-856.

Silver JD, Ritchie ME & Smyth GK (2009) Microarray background correction: maximum likelihood estimation for the normal-exponential convolution Biostatistics 10 (2) 352-363.

Meira-Machado L, U˜na-Alvarez Jd, Cadarso-Su´arezC & Andersen PK (2009) Multi-state models for the analysis of time-to-event data Statistical Methods in Medical Re- search 18 (2) 195-222.

Demography Joﬀe M, Key J, Best N, Jensen TK & Keiding N (2009) The role of biological fertility in predicting family size Human Reproduction 24 (8) 1999-2006.

Hansen MH, Mølgaard-Nielsen D, Knudsen LB & Keiding N (2009) Rates of induced abortion in Denmark according to age, previous births, and previous abortions Demographic Research 21 (22) 647-680.

65 Publications

Epidemiology Andersen R, Brot C, Mejborn H, Mølgaard C, Skovgaard LT, Trolle E & Ovesen L (2009) Vitamin D supplementation does not aﬀect serum lipids and lipoproteins in Pakistani immigrants European Journal of Clinical Nutrition 63 1150-1153.

Gamborg M, Andersen PK, Baker JL, Budtz-Jørgensen E, Jørgensen T, Jensen G & Sørensen TIA (2009) Life course path analysis of birth weight, childhood growth, and adult systolic blood pressure American Journal of Epidemiology 169 1167-1178.

Working group including Budtz-Jørgensen E (2009) Guidance of the Scientific Commit- tee on the request from EFSA on the use of the benchmark dose approach in risk assessment The EFSA Journal 1150 1-72. Iversen MG, Hansen KS, Freil M & Kreiner S (2009) Do surgical patients differ in the way they prioritise aspects of hospital care? Scandinavian Journal of Public Health 37 (3) 295-303. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, Tuomainen T, Murata K, Nielsen HP, Petersen MS, Askham J & Grandjean P (2009) Methylmer- cury exposure and adverse cardiovascular effects in Faroese whaling men Environmental Health Perspectives 117 (3) 367-72.

Lund T, Christensen KB, Vaez M, Labriola M, Josephson M, Villadsen E & Voss M (2009) Diﬀerences in sickness absence in Sweden and Denmark: The cross national HAKNAK study European Journal of Public Health 19 (3) 343-349.

SparsøT, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, Andersen G, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T & Pedersen O (2009) Combined analysis of 19 common validated type 2 diabetes sus- ceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction Diabetologia 52 (7) 1308-1314.

Nabe-Nielsen K, T¨uchsen F, Christensen KB, Garde AH & Diderichsen F (2009) Diﬀerences between day and nonday workers in exposure to physical and psychosocial work factors in the Danish eldercare sector Scandinavian Journal of Work, Environment & Health 35 (1) 48-55.

Labriola M, Feveile H, Christensen KB, B¨ultmannU & Lund T (2009) The impact of job satisfaction on the risk of disability pension. A 15-year prospective study Scandinavian Journal of Public Health 37 (7) 778-780.

Nielsen LH, Løkkegaard E, Andreasen AH, Hundrup YA & Keiding N (2009) Esti- mating the eﬀect of current, previous and never use of drugs in studies based on prescription registries Pharmacoepidemiology and Drug Safety 18 (2) 147-153.

Rayce SLB, Holstein BE & Kreiner S (2009) Aspects of alienation and symptom load among adolescents European Journal of Public Health 19 (1) 79-84.

Schnohr CW, Kreiner S, Rasmussen M, Due P & Diderichsen F (2009) Comparative study on etiological mechanisms generating social inequalities in smoking: The role of children’s school satisfaction and academic achievement Journal of Epidemiology & Community Health 8 (17)

66 Publications

Key J, Best N, Joﬀe M, Jensen TK & Keiding N (2009) Methodological issues in analyzing time trends in biologic fertility: Protection bias American Journal of Epidemiology 169 (3) 285-293.

Rose CS, Grarup N, Krarup NT, Poulsen P, Wegner L, Nielsen T, Banasik K, Færch K, Andersen G, Albrechtsen A, Borch-Johnsen K, Clausen JO, Jørgensen T, Vaag A, Pedersen O & Hansen T (2009) A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads Diabetologia 52 (10) 2122-2129. Gylvin T, Ek J, Nolsøe R, Albrechtsen A, Andersen G, Bergholdt R, Brorsson C, Bang-Berthelsen CH, Hansen T, Karlsen AE, Billestrup N, Borch-Johnsen K, Jørgensen T, Pedersen O, Mandrup-Poulsen T, Nerup J & Pociot F (2009) Functional SOCS1 polymorphisms are associated with variation in obesity in whites Diabetes, Obesity and Metabolism 11 (3) 196-203.

Nørredam ML, Lopez AMG, Keiding N & Krasnik A (2009) Risk of mental disorders in refugees and native Danes: A register-based retrospective cohort study Social Psychiatry and Psychiatric Epidemiology 44 (12) 1023-1029.

Strandberg-Larsen K, Grønbæk M, Andersen AN, Andersen PK & Olsen J (2009) Alcohol drinking pattern during pregnancy and risk of infant mortality Epidemiology 20 (6) 884-891.

Genetics Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proena C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, J¨arvelin M, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski J, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P & Sladek R (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nature Genetics 41 (10) 1110-1115.

Albrechtsen A, Korneliussen TS, Moltke I, Hansen TvO, Nielsen FC & Nielsen R (2009) Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium Genetic Epidemiology 33 (3) 266-274.

Nørremølle A, Budtz-Jørgensen E, Fenger K, Nielsen JE, Sørensen SA & Hasholt L (2009) 4p16.3 haplotype modifying age at onset of Huntington disease Clinical Genetics 75 (3) 244-250.

Nielsen R, Hubisz MJ, Torgerson D, Andres AM, Albrechtsen A, Gutenkunst R, Adams M, Cargill M, Boyko A, Indap A, Bustamante C, Hellmann IG & Clark AG (2009) Darwinian and demographic forces aﬀecting human protein coding genes Genome Research 19 (5) 838-849.

Larsen K, Petersen J, Bernstein I & Nilbert M (2009) A parametric model for analyzing anticipation in genetically predisposed families Statistical Applications in Genetics and Molecular Biology 8 (26) Epub.

67 Publications

Mathematics Harremo¨esP & Holst KK (2009) Convergence of markov chains in information divergence Journal of Theoretical Probability 22 (1) 186-202.

Medicine Mmbando BP, Lusingu JP, Vestergaard LS, Lemnge MM, Theander TG & Scheike TH (2009) Parasite threshold associated with clinical malaria in areas of diﬀerent transmission intensities in north eastern Tanzania BMC Medical Research Methodology 9 75-86.

Mogensen M, Nurnberg BM, Forman JL, Thomsen JB, Thrane L & Jemec GBE (2009) In vivo thickness measurement of basal cell carcinoma andactinic keratosis with optical coherence tomography and 20-MHz ultrasound British Journal of Dermatology 160 1026-1033.

Jepsen JR, Laursen LH, Kreiner S & Larsen AI (2009) Diagnostic accuracy of the neurological upper limb examination II: Relation to symptoms of patterns of ﬁndings Open Neurology Journal 3 54-63.

Burton CM, Iversen M, Carlsen J, Mortensen J, Andersen CB, Steinbruchel D & Scheike T (2009) Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1 Journal of Heart and Lung Transplantation 28 (9) 888-893.

Kastrup J, Johansen JS, Winkel P, Hansen JF, Hildebrandt P, Jensen GB, Jes- persen CM, Kjøller E, Kolmos HJ, Lind I, Nielsen H, Gluud C & CLARICOR Trial Group (2009) High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease European Heart Journal 30 (9) 1066-1072.

Shaker SB, Dirksen A, Ulrik CS, Hestad M, Stavngaard T, Laursen LC, Maltbæk N, Clementsen P, Skjærbæk N, Nielsen L, Stoel B, Skovgaard LT & Tonnesen P (2009) The eﬀect of inhaled corticosteroids on the development of emphysema in smokers assessed by annual computed tomography. Journal of Chronic Obstructive Pulmonary Disease 6 (2) 104-111.

Jørgensen CC, Bundgaard-Nielsen M, Skovgaard LT, Secher NH & Kehlet H (2009) Stroke volume averaging for individualized goal-directed ﬂuid therapy with oesophageal Doppler Acta Anaesthesiologica Scandinavica 53 (1) 34-38.

Sørensen JL, Løkkegaard E, Johansen M, Ringsted C, Kreiner S & McAleer S (2009) The implementation and evaluation of a mandatory multi-professional obstetric skills training program Acta Obstetricia et Gynecologica Scandinavica 88 (10) 1107-1117.

Haissman JM, Vestergaard LS, Sembuche S, Erikstrup C, Mmbando B, Mtullu S, Lemnge MM, Gerstoft J & Ullum H (2009) Plasma cytokine levels in Tanzanian HIV-1-infected adults and the eﬀect of antiretroviral treatment Journal of Acquired Immune Deﬁciency Syndromes 52 (4) 493-497.

68 Publications

Nøjgaard C, Hornum M, Elkjaer M, Hjalmarsson C, Heyries L, Hauge T, Bakkevold K, Andersen PK & Matzen P (2009) Does glyceryl nitrate prevent post- ERCP pancreatitis? A prospective, randomized, double-blind, placebo-controlled multicenter trial Gastrointestinal Endoscopy 69 (6) 31-37.

Cham GKK, Turner L, Lusingu J, Vestergaard L, Mmbando BP, Kurtis JD, Jensen ATR, Salanti A, Lavstsen T & Theander TG (2009) Sequential, ordered ac- quisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains Journal of Immunology 183 (5) 3356-3363.

Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma D, Khalil IF, Theander TG, Lemnge MM & Bygbjerg IC (2009) Five-year surveil- lance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: Accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene American Journal of Tropical Medicine and Hygiene 80 (4) 523-527.

Jespersen CM, Kolmos HJ, Frydendall N, Hilden J, Gluud C, Hansen JF & CLARICOR Trial Group (2009) Compliance with and short-term adverse events from clarithromycin versus placebo in patients with stable coronary heart disease: the CLARICOR trial Journal of Antimicrobial Chemotherapy 64 (2) 411-415.

Nielsen SS, Nørredam M, Christiansen KL, Obel C, Hilden J & Krasnik A (2009) Betydning af opholdstid og antal ﬂytninger p˚aasylbørnspsykiske helbred - sekundærpublika- tion Ugeskrift for læger 171 (12) 981-984.

Gluud C & Hilden J (2009) Povl Heiberg’s 1897 methodological study on the statistical method as an aid in therapeutic trials Preventive Medicine 48 (6) 600-603.

Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS & ISPOCD Group (2009) Long-term consequences of postoperative cognitive dysfunction Anesthesiology 110 (3) 548-555. Hauge AW, Asghar MS, Schytz HW, Christensen K & Olesen J (2009) Eﬀects of tonabersat on migraine with aura: A randomised, double-blind, placebo-controlled crossover study Lancet Neurology 8 (8) 718-723.

Bisgaard H, Loland L, Holst KK & Pipper CB (2009) Prenatal determinants of neonatal lung function in high-risk newborns Journal of Allergy and Clinical Immunology 123 (3) 651- 657. Aagaard L, Nielsen LH & Hansen EH (2009) Consumer reporting of adverse drug reactions: a retrospective analysis of the Danish adverse drug reaction database from 2004 to 2006 Drug Safety 32 (11) 1067-1074.

Claudius C, Viby-Mogensen J & Skovgaard LT (2009) Acceleromyography and mechanomyography for establishing potency of neuromuscular blocking agents: A randomized- controlled trial Acta Anaesthesiologica Scandinavica 53 (4) 449-54.

Nøjgaard C, Matzen P, Andersen PK & Bang UC (2009) Meta-analysis: Nitroglycerin for prevention of post-ERCP pancreatitis Alimentary Pharmacology and Therapeutics 29 (10) 1078-1085. Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sørensen JB, Poulsen HE & Andersen PK (2009) MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer Annals of Oncology 20 (10) 1660-1666.

69 Publications

Kørner A, Lopez AG, Lauritzen L, Andersen PK & Kessing LV (2009) Acute and transient psychosis in old age and the subsequent risk of dementia: A nationwide register- based study Geriatrics & Gerontology International 9 (1) 62-68.

Farrington CP, Firth MJ, Moulton LH, Ravn H, Evans S & Andersen PK (2009) Epidemiological studies of the non-speciﬁc eﬀects of vaccines: II–methodological issues in the design and analysis of cohort studies Tropical Medicine & International Health 14 (9) 977-985.

Hansen TV, Jønson L, Albrechtsen A, Andersen MK, Ejlertsen B & Nielsen FC (2009) Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families Breast Cancer Research and Treatment 115 (2) 315-323.

Sørensen M, L´opez AG, Andersen PK, Vogel U, Autrup H, Tjønneland A, Over- vad K & Raaschou-Nielsen O (2009) Stratiﬁcation for smoking in case-cohort studies of genetic polymorphisms and lung cancer Lung Cancer 63 (3) 335-340.

Hansen TO, Ejlertsen B, Albrechtsen A, Bergsten E, Bjerregaard P, Hansen T, Myrhøj T, Nielsen PB, Timmermans V, Andersen MK, Jønson L, Nielsen R & Nielsen FC (2009) Common Inuit BRCA1 RING domain founder mutation Breast Cancer Research and Treatment 115 (1) 69-76.

Møller LBK, Møller C, Thomsen SG, Andersen LF, Lundvall L, Lidegaard Ø, Kjer JJ, Ingemanssen JL, Zobbe V, Floridon C, Petersen J & Ottesen B (2009) Success and spontaneous pregnancy rates following systemic methotrexate versus laparoscopic surgery for tubal pregnancies: A randomized trial Acta Obstetricia et Gynecologica Scandinavica 88 (12) 1331-1337.

Hansen BR , Petersen J, Haugaard SB, Madsbad S, Obel N, Suzuki Y & Andersen O (2009) The prevalence of metabolic syndrome in Danish patients with HIV infection: The eﬀect of antiretroviral therapy HIV Medicine 10 (6) 378-387.

Jepsen P, Vilstrup H, Ott P, Keiding S, Andersen PK, Tygstrup N (2009) The galactose elimination capacity and mortality in 781 Danish patients with newly-diagnosed liver cirrhosis: A cohort study BMC Gastroenterology 9 (50) 1-6.

Jepsen P, Vilstrup H, Andersen PK, Sørensen HT (2009) Socioeconomic status and survival of cirrhosis patients: A Danish nationwide cohort study BMC Gastroenterology 9 (35) 1-6.

Christophersen IE, Ravn LS, Budtz-Jørgensen E, Skytthe A, Haunsoe S, Svend- sen JH & Christensen K (2009) Familial aggregation of atrial ﬁbrillation: A study in Danish twins Circulation, Arrhythmia and Electrophysiology 2 (4) 278-383.

Feveile H, Christensen KB & Flyvholm M (2009) Self-reported occupational skin contact with cleaning agents and the risk of disability pension Contact Dermatitis 60 (3) 131-135.

Pers TH, Albrechtsen A, Holst C, Sørensen TIA & Gerds TA (2009) The validation and assessment of machine learning: A game of prediction from high-dimensional data PLoS ONE 4 (8) e6287.

70 Publications

Frøkjær VG, Vinberg M, Erritzoe D, Svarer C, Baare W, Budtz-Jørgensen E, Madsen K, Madsen J, Kessing LV & Knudsen GM (2009) High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding NeuroImage 46 (2) 360-366.

Aksglaede L, Sørensen K, Petersen JH, Skakkebæk NE & Juul A (2009) Recent decline in age at breast development: The Copenhagen Puberty Study Pediatrics Electronic Pages 123 (5) 932-939.

Petersen JA, Christensen KB & Steinmetz J (2009) Penetrerende traumer behandlet af akutlægebilen i København Ugeskrift for læger 171 (41) 2982-2985.

Robinson KM, Ottesen B, Christensen KB & Krasnik A (2009) Diagnostic delay experienced among gynecological cancer patients: A nationwide survey in Denmark Acta Obstetricia et Gynecologica Scandinavica 88 (6) 685-692.

Erritzoe D, Frokjaer VG, Haugbol S, Marner L, Svarer C, Baar´eWFC, Rasmussen PM, Madsen J, Paulson OB, Knudsen GM & Holst KK (2009) Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use NeuroImage 46 (1) 23-30. Claudius C, Skovgaard LT & Viby-Mogensen J (2009) Is the performance of acceleromyography improved with preload and normalization? A comparison with mechanomyography Anesthesiology 110 (6) 1261-70.

Schmiegelow K, Heyman M, Kristinsson J, Mogensen UB, Rosthøj S, Vettenranta K, Wesenberg F & Saarinen-Pihkala U (2009) Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 maintenance therapy for higher risk childhood Acute Lym- phoblastic Leukemia: Results from the NOPHO ALL-92 study Journal of Pediatric Hematol- ogy / Oncology 31 (6) 385-392.

Psychiatry Kessing LV, Søndergaard L, Forman JL & Andersen PK (2009) Antidepressants and dementia Journal of Aﬀective Disorders 117 24-29.

Smith EG, Sønderg˚ardL, Lopez AG, Andersen PK & Kessing LV (2009) Association between consistent purchase of anticonvulsants or lithium and suicide risk: A longitudinal cohort study from Denmark, 1995-2001 Journal of Aﬀective Disorders 117 (3) 162-167.

71 Publications

Kørner A, Lopez AG, Lauritzen L, Andersen PK & Kessing LV (2009) Late and very-late ﬁrst-contact schizophrenia and the risk of dementia–a nationwide register based study International Journal of Geriatric Psychiatry 24 (1) 61-67.

Public Health Nielsen ABS, Siersma V, Kreiner S, Hiort LC, Drivsholm T, Eplov LF & Hollnagel H (2009) The impact of changes in self-rated general health on 28-year mortality among middle-aged Danes Scandinavian Journal of Primary Health Care 27 (3) 160-166.

Hansen M, Kreiner S & Hansen CR (2009) CHIPS for sig - læsning for sig Læsepæda- gogen (6) 20-21.

T¨uchsen F, Christensen KB, Feveile H & Dyreborg J (2009) Work injuries and disability Journal of Safety Research 40 (1) 21-24.

Clausen T, Christensen KB, Lund T & Kristiansen J (2009) Self-reported noise exposure as a risk factor for long-term sickness absence Noise & Health 11 (43) 93-97.

Lund T, Labriola M, Feveile H & Christensen KB (2009) The fraction of disability pensions attributable to smoking and obesity. Results from a 15-year follow-up study Journal of Public Health 18 (3) 251-254.

Labriola M, Feveile H, Christensen KB, Strøyer J & Lund T (2009) The impact of ergonomic work environment exposures on the risk of disability pension: Prospective results from DWECS/DREAM Ergonomics 52 (11) 1419-22.

Sociology Siersma V & Kreiner S (2009) A coeﬃcient of association between categorical variables with partial or tentative ordering of categories Sociological Methods & Research 38 (2) 265- 286.

Book

Kreiner S & Carstensen B (2009) Test i Folkeskolen Hans Reitzels Forlag.

Inbook Budtz-Jørgensen E, Keiding N & Grandjean P (2009) Approaches to handling uncertainty when setting environmental exposure standards Baveye P, Mysiak J & Laba M (eds.) Uncertainties in Environmental Modelling and Consequences for Policy Making. (267-280.) Springer Science+Business Media B.V.,

Carstensen B & Kreiner S (2009) Introduktion Carstensen B & Kreiner S (eds.) Test i Folkeskolen. (11-20.) Hans Reitzels Forlag,

72 Publications

Gerds TA, Qvist V, Strub JR, Pipper CB, Scheike T & Keiding N (2009) Failure time analysis Lesaﬀre E, Feine J, Leroux B & Declerck D (eds.) Statistical and Methodological Aspects of Oral Health Research. (259-277.) John Wiley & Sons,

Hilden J (2009) Expected value of sample information, net beneﬁt of sampling Michael W. Kattan (eds.) Encyclopedia of medical decision making. (481-486.) Sage Publications, Hilden J (2009) Bias in scientiﬁc studies Michael Kattan (eds.) Encyclopedia of medical decision making. (80-85.) Sage Publications,

Hilden J (2009) Boolean algebra and nodes Michael W. Kattan (eds.) Encyclopedia of medical decision making. (94-98.) Sage Publications,

Kreiner S (2009) Psykometriske brudstykker - om afprøvning af en matematiktest Carstensen B & Kreiner S (eds.) Test i Folkeskolen. (101-136.) Hans Reitzels Forlag,

Kreiner S (2009) Om udvikling og afprøvning af pædagogiske test Carstensen B & Kreiner S (eds.) Test i Folkeskolen. (43-82.) Hans Reitzels Forlag,

Lange T & Rahbek AC (2009) An Introduction to Regime Switching Time Series Models Andersen TG, Davis RA, Kreiss JP & Mikosch T (eds.) Handbook of Financial Time Series. (871-888.) Springer Verlag,

Inproceedings Dalgaard P (2009) Multivariate linear models and repeated measurements revisited Ivette Gomes, Pedro Luis do Nascimento Silva & Jose Alberto Silva (eds.), Bulletin of the International Statistical Institute (3649-3652) Lissabon

PhD thesis Albrechtsen A (2009) New methods for modeling large scale human of genetic variation data. University of Copenhagen.

Gerster M (2009) Socioeconomic determinants for fertility. University of Copen- hagen.

Rosthøj S (2009) Dynamic statistical modelling of maintenance therapy of children with acute lymphoblastic leukemia. University of Copenhagen.

3.2 Research reports 1. Thomas Scheike, Jeremy Silver Estimating haplotype eﬀects for survival data

73 Publications

2. Marie-Louise H. Hansen, Louise Stage, Lisbeth B. Knudsen, Niels Keiding Do Induced Abortions Aﬀect the First Birth Probability? A National Register- Based Study of Danish Women

3. Richard D. Gill, Niels Keiding Product-limit estimators of the gap time distribution of a renewal process under diﬀerent sampling patterns

4. Volkert Siersma Importance Sampling Strategies for Oﬀ-Policy LSTD(1)

5. Tine Kajsa Kvist, Per Kragh Andersen, Jules Angst, Lars Vedel Kessing Event dependent sampling of recurrent events

6. Thomas Scheike A semiparametric random eﬀects model for multivariate competing risks data

7. Lars Hougaard Nielsen, Niels Keiding Describing episodes of drug treatment from joint observation of a prescription registry and a cross-sectional survey

8. Lars Hougaard Nielsen, Ellen Løkkegaard, Niels Keiding Importance of eﬀect measures in the evaluation of the eﬀect of post menopausal hormone therapy on myocardial infarction

9. Giuliana Cortese, Per Kragh Andersen Competing risks and time-dependent covariates

10. Svend Kreiner, Karl Bang Christensen Item screening in graphical loglinear Rasch models

11. Per Kragh Andersen, Michael Væth Survival Analysis

12. Mette Gerster, Mette Erjnæs, Niels Keiding The eﬀect of educational attainment on ultimate fertility - does feedback play a role?

13. Svend Kreiner, Jørgen Holm Petersen, Volkert Siersma Deriving and testing hypotheses in chain graph models