Department of Pediatrics 2019-2020 Annual Report

DEPARTMENT OF PEDIATRICS

2019-2020 ANNUAL REPORT December 2020 1

TABLE OF CONTENTS

CHAIR’S MESSAGE 2

MISSION, VISION, VALUES, GOALS 3

DEPARTMENT ORGANIZATIONAL CHART 4

DIVISION CHIEFS 5-6

FACULTY 7-17

MENTORING COMMITTEE 18

RESIDENCY PROGRAM 19-25

DIVISION REPORTS 26-114

Cardiology Child’s Voice/Child Abuse Critical Care Developmental and Gastroenterology Endocrinology Behavioral No Report General Pediatrics Genetics Hematology/Oncology

Hospitalists Infectious Disease Neonatology Nephrology Neurology Pallative Care No Report No Report Physical Medicine/Rehab Pulmonology Research No Report Surgery

PILLAR 2 and 3 CLERKSHIP No Report

CONTINUING MEDICAL EDUCATION (Grand Rounds) 115

DEPARTMENT AWARDS 116-117

RESEARCH AND SCHOLARSHIP DAY/ABSTRACT PRESENTATIONS Cancelled

SANFORD BLACK HILLS SYMPOSIUM Cancelled

DEPARTMENT OF PEDIATRICS A Message from our Interim Chair

Welcome to the 2019-2020 Department of Pediatrics Annual Report! As Interim Chair, I am honored to share with you the accomplishments and concerns of the department during our time of the COVID-19 pandemic. Despite the “wrench in the works” spread of a novel virus, our Faculty and Residents continued their teaching, service, and scholarly activities, contributing to the excellence expected of our medical school.

Highlights within these pages include promotions and awards; update of the Pediatric Residency program and departmental divisions; and the Research and Scholarly activities of the Department of the School of Medicine over the past year.

As with any year there was the addition of new faculty members and the departure of respected colleagues. Thanks to the pandemic, there were a number of cancellations of departmental conferences and activities. Despite the viral interruption, our department continues to support the medical education mission of the medical school and advance the cause of pediatric education.

This year congratulations go to Dr. Michelle Schimelpfenig who received the Departmental Dedi- cated Teacher Award and Dr. Kameswaran Surendran who received the Departmental Distin- guished Researcher Award.

Dr. Archana Chatterjee, our former Department Chair, departed April 6, 2020 to become the Dean of the Chicago Medical School at the Rosalind Franklin University of Medicine and Science. We wish her success. As she has stated in past annual departmental reports, “We value diversity and its essential role in achieving the educational, scholarship, and service missions of the school and remain committed to the recruitment and retention of students, residents, faculty, and staff who through their diversity enrich the learning environment and promote inclusive excellence. We recognize diversity as relating to race, ethnicity, creed, rural background, socioeconomic status, gender, sexual orientation, age, and disability. In addition, we value persons with broad life experiences, with records of service to disadvantaged populations, and with other attributes that may enhance the learning community.” That belief continues and I thank the medical students, residents, faculty and staff in the Department who continue to support our educational curriculum and scholarly pursuits.

Finally, our Staff, Department Manager Ms. Janet Reider and Medical Education Coordinator Ms. Angie Tuffs, are truly dedicated and make our department successful. I express my heartfelt thanks to both for warmly welcoming me to the role of Interim Chair and especially to Ms. Reider for putting together this report.

Sincerely,

Joseph A. Zenel, MD Professor and Interim Chair, Department of Pediatrics

Vision Statement: The Department of Pediatrics at the Sanford School of Medicine of The University of South Dakota will be acknowledged as a leader in educating students, residents, fellows, physicians and allied health professionals in the discipline of pediatrics, be recognized for providing extraordinary, compassionate care to pediatric patients and their caregivers, be renowned for the creation and dissemination of new knowledge in the field of pediatrics, and be valued as an advocate for children. Mission Statement: The Mission of the Department of Pediatrics at the Sanford School of Medicine of The University of South Dakota is to provide all learners with an exceptional educational experience in pediatrics, to deliver the highest quality of care to pediatric patients and their caregivers, to create and dissemi- nate new knowledge to improve the health and wellbeing of all children, and to be an advocate for children. Values: The members of the Department of Pediatrics at the Sanford School of Medicine of The University of South Dakota espouse the following values:

1. Educators in pediatrics, as role models, should impart in a culturally appropriate manner, the knowledge and skills related to pediatric medicine, that students and residents require to become good physicians. 2. Members of the department are expected to demonstrate and inculcate the highest levels of professionalism, respect, and integrity in their interactions with students, residents, patients and their caregivers, colleagues and staff. 3. Diversity and inclusiveness are respected and highly valued in our department. Gender, race, color, creed, ethnicity, disability status, religion, sexual orientation, nationality, age, vet- eran status, and other important social identities are all equally accepted and respected in our department.

Goals: 1. To provide high-quality pediatric education at the undergraduate (medical student), graduate (resident and fellow) and professional (continuing professional development) level. 2. To serve the children of South Dakota and the region by providing compassionate, exem- plary health care through medical education and research, by serving as a clinical and technical resource to other care providers and agencies. 3. To advance medical knowledge in the field of pediatrics through basic science, clinical and translational research, as well as other scholarly activities. 4. To expand pediatric services throughout the region. 5. To serve as advocates for children’s health and well-being. 6. To serve as a leadership resource in the realm of pediatrics. 7. To support and encourage Faculty Development.

DEPARTMENT OF PEDIATRICS SANFORD SCHOOL OF MEDICINE ORGANIZATIONAL CHART

Joseph Zenel, MD George Maher, DO Interim Department Chair Department Vice Chair

Janet Reider Angela Tuffs Department Manager Medical Education Department Assistant

DIVISION CHIEFS

Alaa Al Nofal, MD Fernando Bula-Rudas, MD Bonnie Bunch, MD Endocrinology Infectious Diseases Neurology

Laura Davis-Keppen, MD Amy Elliott, PhD Nancy Free, MD Genetics Avera Research Child’s Voice

Carl Galloway, MD Carrie Kippes, MD George Maher, DO Hospital Medicine Developmental and Behavioral Hematology-Oncology

Daniel Mark, MD Gary Neidich, MD Suzanne Reuter, MD Palliative Care Gastroenterology Neonatology

Jon Ryckman, MD John Sanders, MD Jody Huber, MD Surgical Specialties Nephrology Critical Care Medicine Anesthesiology and Radiology

No Current Division Chief Theresa Stamato, MD Michelle Baack, MD Physical Medicine & Rehab Cardiology Sanford Research

James Wallace, MD Aaron Zylstra, MD Pulmonology and Sleep Disorders General Pediatrics Allergy and Immunology

FACULTY

**Sanford School of Medicine New Faculty

Adamiak Tonya MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Al Nofal Alaa MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Ali Mir MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department **Anderson Kathryn MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Angal Jyoti MPH Instructor Avera Research Institute Academic - Clinical Department Arain Nofil MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Baack Michelle MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Baete Kenyon DenYelle PhD Professor USD Sanford School of Academic - Clinical Medicine Department **Barber Maria DO Assistant Professor Avera McKennan Academic - Clinical Hospital & University Department Blake Jerome MD Associate Professor Academic - Clinical Department Bollig Kristine MS Instructor Center for Disabilities Academic - Clinical Department Bragg Dawn PhD Professor USD Sanford School of Academic - Clinical Medicine Department Brudvig Jonathan PhD Assistant Professor Sanford Research Academic - Clinical Department Bula-Rudas Fernando MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Bunch Bonnie MD, PhD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Callaway Daniel MD, MPH Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Chandrasekar Indra PhD Assistant Professor Sanford Children's Health Academic - Clinical Research Center Department Davis-Keppen Laura MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department Deutsch Arielle PhD Assistant Professor Sanford Research Academic - Clinical Department Dsouza Shalome MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Eggerstedt Tova MS Instructor Center for Disabilities Academic - Clinical Department Elliott Amy PhD Professor Avera Research Institute Academic - Clinical Department Faustino Randolph PhD Assistant Professor Sanford Research Center Academic - Clinical Department

Francis Kevin PhD Assistant Professor Sanford Children's Health Academic - Clinical Research Center Department Friedrich Christa MS Instructor Avera Research Academic - Clinical Department Grev Jacquelyn MD Assistant Professor Sanford Children's Academic - Clinical Clinic Department Griese Emily PhD Assistant Professor Sanford Children's Health Academic - Clinical Research Center Department Griffin Kurt MD, PhD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Groeneweg Ryan EdS Assistant Professor Center for Disabilities Academic - Clinical Department Hansen Sara EdD Assistant Professor Center for Disabilities Academic - Clinical Department **Hockett Christine PhD Assistant Professor Center for Pediatric & Academic - Clinical Community Research Department Hogden Laurie MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Hsu Benson MD, MBA Associate Professor Sanford Childrens Hospi- Academic - Clinical tal Department Huber Jody MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Jain Amit MBBS Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Jensen Melissa MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Johnson John PhD Associate Professor Center for Disabilities Academic - Clinical Department **Johnson Marni AuD Associate Professor Center for Disabilities Academic - Clinical Martin Department Jones Brooke MD Assistant Professor Child's Voice Sanford Academic - Clinical Medical Center Department Kareta Michael PhD Assistant Professor Sanford Children's Academic - Clinical Research Center Department Kippes Carolyn MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Knutson Lacy MS Instructor Sanford School of Academic - Clinical Medicine Department Kovacs Attila PhD Assistant Professor Sanford Children's Health Academic - Clinical Research Center Department Kurtz Eric PhD Associate Professor Center for Disabilities Academic - Clinical Department Landsverk Megan PhD Associate Professor Ambry Genetics Academic - Clinical Department Lee Lance PhD Associate Professor Sanford Research Academic - Clinical Department Lopez Santiago MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Mark Daniel MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Meier Emily MA Instructor USD Sanford School of Academic - Clinical Medicine Department

Messier Stephen MD Associate Professor Sanford Childrens Academic - Clinical Specialty Clinic Department Meyer Lauritz MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Munce Thayne PhD Associate Professor Sanford Sports Science Academic - Clinical Institute Department Munson David MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department **Murphy Brianna DO Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Neidich Gary MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Nelson Morgan MS Instructor Avera Research Institute Academic - Clinical Department Olgun Gokhan MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Pearce David PhD Professor Sanford Research Academic - Clinical Department **Pilaz Louis-Jan PhD Assistant Professor Sanford Research Academic - Clinical Department Reed Jennifer MD Associate Professor Sanford Children's Academic - Clinical Specialty Clinic Department Reuter Suzanne MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department Roux Kyle PhD Associate Professor Sanford Research Academic - Clinical Department Sandeen Ashley DO Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Savinov Alexei MD, PhD Associate Professor Sanford Research Academic - Clinical Department Schimelpfenig Michelle DO, MPH Associate Professor Sanford Children's Academic - Clinical Clinic - MB2 Department Sebera Brandy MS Instructor Center for Disabilities Academic - Clinical Department Segeleon Joseph MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department Selya Arielle PhD Associate Professor Sanford Research Office Academic - Clinical 2248 Department Steinbrekera Baiba MD Assistant Professor Sanford Children's Academic - Clinical Hospital Department Surendran Kameswa- PhD Associate Professor Sanford Research Academic - Clinical ran Department Tao Jianning PhD Assistant Professor Sanford Children's Health Academic - Clinical Research Center Department Thompson Paul PhD Professor Academic - Clinical Department **Tobacco Deborah MA Instructor Research Institute Center Academic - Clinical for Pediatric Department Wagner KayeLyn MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Wallace James MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department

Waltz William MD, PhD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Ward David MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Warne Jim MS Instructor Center for Disabilities, Academic - Clinical Oyate' Circle Department Weimer Jill PhD Associate Professor Sanford Research Academic - Clinical Department **Weston Wayne BA Instructor Center for Disabilities Academic - Clinical Department Whalen Lesta MD Assistant Professor Sanford Children's Academic - Clinical Hospital Department White Jessica MD Assistant Professor Sanford Children's Academic - Clinical Specialty Clinic Department Wilson Ann PhD Professor Center for Disabilities Academic - Clinical Department Ye Ping PhD Associate Professor Center for Pediatric & Academic - Clinical Community Research Department Zenel Joseph MD Professor Sanford Children's Academic - Clinical Specialty Clinic Department Battaglia Agatino MD Adjunct Professor Stella Maris Clinical Adjunct - Clinical Research Institute Department Chatterjee Archana MD, PhD Adjunct Professor Chicago Medical School, Adjunct - Clinical Office of the Dean Department Cheyne Ken MD Adjunct Professor Blank Adolescent Clinic Adjunct - Clinical Department **Crotwell Patricia PhD Adjunct Associate EGL Genetics Adjunct - Clinical Leiferman Professor Department Guo Zhiguang MD, PhD Adjunct Professor Sanford Research Adjunct - Clinical Department Itkin-Ansari Pamela PhD Adjunct Associate Sanford-Burnham Medi- Adjunct - Clinical Professor cal Research Institute Department Keros Sotirios MD, PhD Adjunct Associate Adjunct - Clinical Professor Department May Philip PhD Adjunct Professor Gillings School of Global Adjunct - Clinical Public Health Department Milanovich Sam MD Adjunct Assistant Sanford Roger Maris Adjunct - Clinical Professor Cancer Center Department Parent-John- Wendy PhD Adjunct Professor University of Arizona Adjunct - Clinical son College of Medicine Department Peters Stacy PharmD Adjunct Associate Sanford Children's Adjunct - Clinical Professor Specialty Clinic Department Snyder Evan MD, PhD Adjunct Professor Sanford Burnham Prebys Adjunct - Clinical Medical Discovery Inst Department Specker Bonny PhD Adjunct Professor Ethel Austin Martin Adjunct - Clinical Endowed Prog Department Vitiello Peter PhD Adjunct Associate Oklahoma University Adjunct - Clinical Professor Health Sciences Center Department Woltanski Amelia MS Adjunct Associate Sanford Medical Genetics Adjunct - Clinical Mroch Professor Lab Department Abrahamson Beth BSN, NNP Clinical Instructor Sanford Children's Clinical Hospital -NICU

Allison Marty MD Clinical Associate Avera Medical Group Clinical Professor Pierre Anderson Gregory DO Clinical Associate Black Hills Pediatrics & Clinical Professor Neonatology, LLP Anderson Halie MD Clinical Assistant Rapid City Medical Clinical Professor Center Arnold Christine MD Clinical Associate Sanford Health Mitchell Clinical Professor Clinic **Arrobas Jade DO Clinical Instructor USD Sanford School of Clinical Medicine Ashbaugh Shannon MD Clinical Associate Sanford Clinic - 69th and Clinical Professor Louise Aukerman M. Ranae BSN, NNP Clinical Instructor Sanford Children's Clinical Hospital - NICU Awadallah Sami MD Clinical Professor Avera Medical Group Clinical Pediatric Specialists Backer Courtney MD Clinical Assistant Avera McGreevy Clinic Clinical Professor Bagwe Ashlesha MBBS Clinical Instructor USD Sanford School of Clinical Medicine Balay Kimberly MD Clinical Assistant Monument Health Rapid Clinical Professor City Hospital **Barnes Jessica DO Clinical Instructor USD Sanford School of Clinical Medicine Barondeau Jesse MD Clinical Assistant Avera Medical Group Clinical Professor Pediatrics Bauer Barry MD Clinical Professor Sanford Children's Clinic Clinical

Bauer Elizabeth MD Clinical Associate Sanford Children's Clinic Clinical Professor 26th & Sycamore Baum Kyle DO Clinical Instructor USD Sanford School of Clinical Medicine Benn Steven MD Clinical Professor Monument Health Rapid Clinical City Hospital Bishop Nina MD Clinical Instructor Sanford Clinic Watertown Clinical

Bjornson Kerri MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Bjornson Tige MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Blumhoff Ashlee MSN Clinical Instructor Sanford Children's Clinical Specialty Clinic Bonine Shea MS Clinical Instructor Sanford Children's Clinical Specialty Clinic Boote Rochelle MD Clinical Associate Avera Medical Group Clinical Professor McGreevy 69th and Cliff Bosch Rosanne MD Clinical Associate Sanford Children's Clinic Clinical Professor Brende Tiffany MSN, Clinical Instructor Sanford Children's Clinical BSN Hospital - NICU Broberg Charles MPAS Clinical Instructor Sanford Children's Clinical Specialty Clinic/Lifescape

Bruning Kara MD Clinical Associate Avera Medical Group Clinical Professor McGreevy Pediatrics Brynjulson Molly NNP Clinical Instructor Sanford Children's Clinical

Buenaven- Ariane DO Clinical Instructor USD Sanford School of Clinical tura Medicine Bulatao Shelly MSN Clinical Instructor Sanford Child's Voice Clinical

Burch Lynette DNP Clinical Instructor Sanford Children's Clinical Hospital - NICU Cass Teresa MSN Clinical Instructor Avera Medical Group Clinical Pierre Christian Rafael MD Clinical Associate Kyle Health Center Clinical Professor **Coaston Ashley DO Clinical Instructor USD Sanford School of Clinical Medicine Cole Sarah MD Clinical Assistant Avera McKennan Clinical Professor davis Craig MD Clinical Professor Brown Clinic Clinical

Dasgupta Kingshuk MD Clinical Associate Avera McKennan Clinical Professor Children's Hospital Dosado Jose Mar- MD Clinical Associate Avera McKennan Clinical ius Professor Hospital Doubledee Brock DO Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Dykstra Tressa MSN Clinical Instructor Sanford Children's Clinical Specialty Clinic Edelen Rachel MD Clinical Associate Monument Health Rapid Clinical Professor City Clinic Eich Shari MD Clinical Associate Avera Medical Group Clinical Professor McGreevy Elliott Michael MD Clinical Professor Sr. VP of Medical Clinical Affairs/CMO Finch Sudhir MD Clinical Assistant Avera McKennan Clinical Professor Pediatric Critical Care Fjellanger Pam MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Free Nancy DO Clinical Professor Sanford Childrens Clinic - Clinical Childs Voice Galloway Carl MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Gehrmann Rebecca MD Clinical Instructor USD Sanford School of Clinical Medicine Gupta Ashutosh MD Clinical Associate Avera Medical Group Clinical Professor Pediatric Specialty Clinic Haggar Jennifer MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Hamilton Cara MD Clinical Professor Black Hills Pediatrics & Clinical Neonatology, LLP Hanisch Karen MS, RN, Clinical Instructor Sanford Children's Clinical CNP Specialty Clinic

Heisinger Randolph MD Clinical Professor Clinical

Henry Scott MD Clinical Professor Sanford Children's Clinical Clinic-MB2 Hentges Caleb DO Clinical Instructor USD Sanford School of Clinical Medicine Hickman Deborah DNP,MSN Clinical Instructor Sanford Childrens Clinical RN Specialty Clinic Hoime Shannon MD Clinical Associate Avera Medical Group Clinical Professor McGreevy Huffingham Ashley MD Clinical Assistant Brookings Sanford Clinic Clinical Professor Hutton Natalie MD Clinical Assistant Avera Medical Group Clinical Professor Pierre - MAC Lane Jarding Laura MSN Clinical Instructor Sanford Children's Clinical Hospital Johnson Julie MD Clinical Professor Sanford Children's Clinical

Johnson Heather MS, RN, Clinical Instructor Sanford Children's Clinical CNP Specialty Clinic Jones Tracy DO Clinical Associate Sanford 69th and Louise Clinical Professor Family Medicine Kampshoff Arlene CNP Clinical Instructor Sanford Children's Clinical Hospital - NICU Kanala Vishnu MBBS Clinical Associate Sanford Childrens Clinical Professor Specialty Clinic Kastl Justin MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Khan M. Akram MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Knecht Cartney MS Clinical Instructor Sanford Children's Clinical Specialty Clinic Koenig Aimee MD Clinical Instructor USD Sanford School of Clinical Medicine Koens Debra MSN, Clinical Instructor Sanford Children's Clinical CNP Hospital - NICU Kooima Rick MD Clinical Professor Avera Medical Group Clinical McGreevy Kovarik Stephen MD Clinical Professor Monument Health Rapid Clinical City Hospital Krell Matthew MD Clinical Associate Vermillion Medical Clinic Clinical Professor Kuehler Margaret MD Clinical Associate Black Hills Pediatrics & Clinical Professor Neonatology, LLP Larson Dawn MD Clinical Professor Yankton Medical Clinic Clinical

Larson Katie MD Clinical Associate Sanford Children's Clinic Clinical Professor Lim Peter Paul MD Clinical Assistant Avera Pediatrics Plus Clinical Professor Lubbers Lisa MSN, Clinical Instructor Avera McKennan Clinical NNP Hospital NICU

Luzier Thomas MD Clinical Assistant Aberdeen Asthma & Clinical Professor Allergy Maher George DO Clinical Professor Sanford Children's Clinical Specialty Clinic Mailloux Edward MD Clinical Professor Sanford Children's Clinic Clinical

Mangat Shehbeet MBBS Clinical Instructor USD Sanford School of Clinical Medicine Maroun Christiane MD Clinical Professor Avera Medical Group Clinical McGreevy Martin Roger MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU **Martino Anna-Lisa MD Clinical Instructor USD Sanford School of Clinical Medicine Matthes Cindy BS Clinical Instructor Sanford Children's Clinical Specialty Clinic Maurer Colleen BSN, NNP Clinical Instructor Sanford Children's Clinical Hospital - NICU Mayo Julie DO Clinical Associate Sanford Children's Clinical Professor Specialty Clinic McKercher Scott MD Clinical Professor Sanford Children's Clinic Clinical 26th & Sycamore Meis Megan DO Clinical Instructor Orange City Medical Clinical Clinic Mergen Kara MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Mortimer Sam MD Clinical Professor Black Hills Pediatrics & Clinical Neonatology, LLP Moser Chuanpit MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Mueller David DO Clinical Professor Black Hills Pediatrics, LLP. Clinical

Nano Gisella MD Clinical Assistant Sanford Children's Clinical Professor MB 2 Clinic Nanton Stephen MD Clinical Associate Avera Medical Group Clinical Professor Pediatric Specialists Nearman Debra MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Nelson Candice MD Clinical Professor Sanford Childrens 69th Clinical and Louise **Nelson Nathaniel DO Clinical Instructor USD Sanford School of Clinical Medicine Nevarez Gil- Ana MD Clinical Instructor USD Sanford School of Clinical bert Medicine Oakland Jeffrey OD Clinical Associate Dakota Vision Center Clinical Professor Ohden Lisa MS Clinical Instructor Sanford Children's Spe- Clinical cialty Clinic Olcott Jessica MD Clinical Assistant Sanford Children's Clinical Professor Specialty Clinic Olgun Gulsah MD Clinical Assistant Sanford Children's MB2 Clinical Professor

Olson Bretta MD Clinical Assistant Avera Medical Group Clinical Professor Pierre Clinic O'Neil Amanda RN, MSN, Clinical Instructor Boekelheide Neonatal Clinical CNP Intensive Care Unit Ortman Charisse MSN, Clinical Instructor Sanford Children's Clinical Brockmueller NNP Hospital - NICU Paul Lynn MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Peck Elizabeth MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Pepper Sara MD Clinical Instructor Yankton Medical Clinic Clinical

Pierret Tracy MD Clinical Associate Sanford Clinic Clinical Professor Watertown Poppinga Nicole MD Clinical Associate Avera Medical Group Clinical Professor Pierre Presson Joseph DO Clinical Instructor USD Sanford School of Clinical Medicine Pritchett Deborah PharmD Clinical Associate Sanford Children's Clinical Professor Hospital Rabenberg Rita MD Clinical Professor Sanford Children's Clinic Clinical MB2 Rall Mathia MSW Clinical Instructor Sanford Children's Clinical Specialty Clinic Raschein Taryn MD Clinical Instructor USD Sanford School of Clinical Medicine Reece Kayli MD Clinical Assistant Sanford Children's Clinic Clinical Professor Reitsma Jenifer MSN, RN Clinical Instructor Sanford Children's Clinical Specialty Clinic Reynolds Daniel DO Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Rivera Nicolas MD Clinical Associate Avera Pediatric Critical Clinical Professor Care/Hospitalist Service Robare Tara DO Clinical Instructor USD Sanford School of Clinical Medicine Sanchez Jorge MD Clinical Associate Monument Health Clinical Professor Neurology & Rehab Sanders John MD Clinical Associate Sanford Children's Clinical Professor Specialty Clinic Schimelpfenig Samuel MD Clinical Professor Avera McGreevy Clinic Clinical

Schroeder Erin MSN Clinical Instructor Sanford Children's Clinical Specialty Clinic Sharp Justin MD Clinical Assistant Avera McKennan Clinical Professor Hospital Shelso John MD Clinical Professor Sanford Children's Clinical Specialty Clinic Soares Fernando MD, MBA Clinical Associate Avera McKennan Clinical Professor Hospital Spahn Martin MD Clinical Associate Founders Park Clinic, Clinical Professor Prof. LLC

Sreedharan Suresh MD Clinical Associate NW Medical Center Clinical Professor Stamato Theresa MD Clinical Professor Sanford Children's Clinical Specialty Clinic **Steventon Daniel DPT Clinical Assistant Physical Medicine and Clinical Professor Rehabilitation **Stille Emelia DO Clinical Instructor USD Sanford School of Clinical Medicine Stoll Deanna MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Strong Lori MD Clinical Professor Black Hills Pediatrics & Clinical Neonatology, LLP Stuive Kristin DO Clinical Instructor USD Sanford School of Clinical Medicine Tegethoff Jennifer MD Clinical Associate Avera Medical Group Clinical Professor Pediatrics Tesoro Ovictor MD Clinical Assistant Avera Medical Group Clinical Professor Pediatrics Specialists Thorpe Kassy MD Clinical Assistant Clinical Professor Torbert Nicholas DO Clinical Instructor Avera McGreevy Medical Clinical Group Towe Eric MD Clinical Assistant Avera Medical Group Clinical Professor Pediatric Subspecialists Ulmer Tara MD Clinical Assistant Monument Health Clinical Professor Spearfish Clinic Van Beek Michelle MD Clinical Professor Sanford Children's Clinic Clinical 26th & Sycamore Van Dam Stephanie MSN, Clinical Instructor Sanford Children's Clinical FNP Specialty Clinic Van Heuke- Jesse MD Clinical Assistant HRMC Physician Clinic Clinical lom Professor VanTol Mallary MSN Clinical Instructor Sanford Children's Clinical

Veloira Wilfredo MD Clinical Associate Avera Children's Clinical Professor Vetter Wendy DO Clinical Associate Sanford 34th and Kiwanis Clinical Professor Family Medicine Vo Richard MD Clinical Instructor USD Sanford School of Clinical Medicine Vogel Joseph MD Clinical Associate Avera Medical Group Clinical Professor Wang Katherine MD Clinical Associate Avera Medical Group Clinical Professor Neonatology Ward Lynn MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital - NICU Weidauer Jacquel- MSN Clinical Instructor Sanford Children's Clinical ine Weinacht Donna MD Clinical Professor Sanford Childrens 69th Clinical and Louise Wellman Lawrence MD Clinical Professor Clinical

Whitney David MD Clinical Professor Black Hills Pediatrics & Clinical Neonatology Whittington Laura DO Clinical Assistant Sanford Children's Clinic Clinical Professor 69th and Louise Willman April MD Clinical Associate Yankton Medical Clinic Clinical Professor Wilson Elizabeth MSN, Clinical Instructor Sanford Children's Clinical NNP Hospital -- NICU Withrow David MD Clinical Professor Yankton Medical Clinic Clinical

Zimmerman Nicole MD Clinical Instructor USD Sanford School of Clinical Medicine Zylstra Aaron MD Clinical Professor Sanford Childrens 69th Clinical and Louise Fenton Lawrence MD Professor Emeritus Sanford Children's Emeritus Specialty Clinic Hoyme H. Eugene MD Professor Emeritus Emeritus

Stevens Dennis MD, MS Professor Emeritus Sanford Children's Emeritus Specialty Clinic Struck Judy EdD Professor Emeritus Emeritus

PEDIATRIC MENTORING COMMITTEE

Jennifer Giancola, PhD Nofil Arain, MD Shannon Carruthers, MD Organizational Trainer and Consultant

Indra Chandrasekar, PhD Kurt Griffin, MD, PhD George Maher, MD

Suzy Reuter, MD Bill Waltz, MD Joseph Zenel, MD

RESIDENCY PROGRAM

Joseph Zenel, MD Program Director

KayeLyn Wagner, MD Kelley Yseth Associate Program Director Program Coordinator

2020 RESIDENCY PROGRAM

For the academic year 2020-21 we matched 6 categorical residents. One is from a LCME accredited school and two are from AOA accredited schools, allocated in the United States, and three are from ECGMG certified schools.

This past year we had 385 applicants, of whom 99 interviews were offered. We interviewed 64 applicants from 16 allopathic schools, 11 osteopathic schools and 11 foreign countries.

The program is now 10-years-old. Over this time, we have recruited 30 allopathic and 29 osteopathic medical students from 11 osteopathic schools and 15 allopathic schools from 23 states in the US and 1 MD from Ecuador and 2 MBBS from India. Approximately half of our graduates now practice in South Dakota and North Dakota.

Program accomplishments this past year

1. We graduated our seventh residency class this June 30, 2020 (6 residents). Four residents went into general pediatrics practice: one for the US Air Force at Keesler Air Force Base in Biloxi, Mis- sissippi, one in private practice in Fort Madison, Iowa, one in Farmington, New Mexico and one at Sanford Health, Fargo, North Dakota. One resident became our chief resident who was then hired to become a hospitalist at Sanford Children’s Hospital in Sioux Falls. Finally one resident entered a pediatrics endocrinology fellowship at the Mayo Clinic.

2. Five of the six 2019 resident graduates who took the American Board of Pediatrics Initial Certifi- cation Exam passed the exam bringing our program’s success rate of passing the Initial Certifica- tion Exam first-time to 91% and our overall resident passing rate to 94%. Of note, the national passing rates for pediatric residency programs are 87% and 96% respectively. Our program median score (198) is exactly at the national median (198), which is shown below. Our graduates’ examination performance compared to the nation for the past 7 years:

3. Two of our current third-year residents are applying for fellowships (pediatrics emergency medicine, pediatric hematology oncology). One resident already has a commitment to a general pediatrics practice in Wisconsin. Another resident is seeking practice in outpatient general pediatrics. One resident is seeking a position in pediatrics emergency medicine. The last resident has a US Air Force commitment. A seventh resident was dismissed from the program on October 26, 2020.

4. The ACGME gave the residency program continued accreditation in March 2020 as well as a letter of commendation for substantial compliance (only 20% of pediatric residencies receive such a letter). The program has received a letter of commendation for substantial compliance four times in a row now, with 5 such letters over a 10-year span. a. There are no citations at present.

5. This year the ACGME had a focused site visit of the program on October 12 because of a resident complaint and resident & faculty survey results that suggested there might be issues. No immediate major concerns were raised by the focused site visit. The ACGME Pedi- atrics Review Committee meets in January 25-27 and will decide on the outcome of the site visit at that time. A GME Special Review suggested program improvements (See 2020-21 Plans)

6. Yoga classes and cooking classes for residents and faculty were held throughout the year, arranged by the Residency Wellness Committee.

7. The residents had an overnight trip to the State Capitol in Pierre, SD to partake in Children’s Day at the Capitol and to lobby against a proposed law to make the medical referral of a transgender child a class 2 misdemeanor. A representative from the AAP Legislative Com- mittee also attended. Below is an excerpt from the American Academy of Pediatrics News- letter of the event.

Planned changes for 2020-21  Timely feedback in each rotation (Feedback directly between learner and attending verbally and then documented formally in NI)  Standardize interaction with subspecialists/consults  Build goodwill between faculty and residents (retreats)  Residents show appreciation for faculty  Faculty should make sure curriculum/teaching is robust to address concern residents are “not ready for independent practice.”  Program and chief resident create lecture series on “Interpersonal and Communication Skills” (including conflict management)  Reexamine didactic schedule for efficiency, value, protected time (minimize interruptions).  Pursue board-certified Emergency Medicine and Adolescent Medicine pediatricians  Residents develop “resident handbook” for each rotation  Residents engage in more teaching and “senioring.” (Seniors take a more formal role in teaching noon conferences and helping junior residents learn specifics about each rotation and attending)

Resident Accomplishments Peer-reviewed Publications  Case 2: Blindness and Loss of Gross Motor Skills in a Young Toddler. Whitney Rolling, Fer- nando Bula-Rudas, Carl S. Galloway, Vishnu Kanala, Geoffrey Tufty, Archana Chatterjee. Pedi- atrics in Review, Feb 2020, 41 (2) 84-87  Jackson S. Bilateral femoral fractures in an Adolescent Male due to Severe Vitamin D Defi- ciency. South Dakota Journal (accepted) National/Regional Posters  Dr. Emelia Stille presented on “Lactational Exposure to High-Fat Diet and Metformin Incites Myo- cardial Lipid Accumulation in Adult Male Offspring” at the Midwest Society for Pediatric Research Virtual Scientific Meeting on Friday, October 9. Committees  USD SSOM GME Committee – Jessica Barnes DO

Joe Zenel, MD; Residency Program Director Accomplishments  Interim Chair, Department of Pediatrics, University of South Dakota Sanford School of Pediatrics  Editor-in-Chief, Pediatrics in Review, American Academy of Pediatrics, January 2013 – present Peer-reviewed Publications  Zenel JA. Pediatrics in Review: Questions for the 41st Year. Pediatr Rev. 2020 Jan;41(1):1-2. doi: 10.1542/pir.2019-001. PMID: 31894067  Schumacher DJ, Schwartz A, Zenel JA Jr, Black NP, Ponitz K, Blair R, Traba CM, Poynter S, King B, Englander R, Rosenberg A, Patel D, Smith-King C, O'Connor M, Gonzalez Del Rey J, Lavoie S, Borman-Shoap E, Carraccio C; Association of Pediatric Program Directors (APPD) Longitudinal Educational Assessment Research Network (LEARN) General Pediatrics Entrusta- ble Professional Activities Study Group. Narrative Performance Level Assignments at Initial En- trustment and Graduation: Integrating EPAs and Milestones to Improve Learner Assessment. Acad Med. 2020 Mar PMID: 32195689 Committees--National  Member, American Board of Pediatrics Educational and Training Committee, January 2019 – present  Member, USMLE Abstracts TMDC, Step 2 National Board of Medical Examiners, February 2015 – present; Chair June 2019 -  Member, USMLE Evidence-based Medicine Interdisciplinary Review Committee, National Board of Medical Examiners, January 2015 – Present  Member, American Academy of Pediatrics Committee on Pediatric Education, January 2013 – present  Member, Step 2 Interdisciplinary Review Committee USMLE Step 2 National Board of Medical Examiners, 2004 – present

Committees--USD Sanford School of Medicine  Medical Education Committee, July 2018 – present  Student Progress and Conduct Committee, March 2018 – present  MD/PhD Admissions Committee – 2016 - present  Chair, GME Residency Recruiting Committee, 2011 – present  Graduate Medical Education Committee, August 2008 – present Committees--Sanford Health  Sanford Health Plan Physician Quality Committee, 2017 – present  Claims, Risk and Patient Relations Committee, September 2011 – present  Pediatric Care Monitoring Committee, December 2008 – present

DIVISION CHIEF REPORTS

Cardiology Dr. Theresa Stamato, Division Chief Division Members Dr. Nofil Arain (NA); Associate Professor of Pediatrics Dr. Edgard Bendaly (EB); Associate Professor of Pediatrics Dr. Theresa Stamato (TS); Clinical Professor of Pediatrics Dr. William Waltz (BW); Associate Professor of Pediatrics

Teaching Medical Students Pillar 1  Clinical Correlations Lecture- Cardiac embryology and shunt physiology (BW) Pillar 2  Caleb Wenz  Natalie Walter  Casey Hanson  Stephanie Kazi  Justin Brown  Jordan Dykstra  Kindra Holsing  Rebecca Glanzer  Thomas Vierhout  Elise Blaseg Pillar 3  Tyler Sternhagen  Kayla Muncher  Ethan Nemmers  Sarah Scott Lectures  Pediatric cardiac history (BW)  Pediatric cardiac physical exam (BW)  Murmurs and heart sounds (BW)  Cyanotic newborn (TS) Small Groups  Pediatric EKG primer (BW & NA)  Arrhythmia recognition (BW)

Residents Electives  Pediatric Cardiology mandatory elective- (NA, EB, TS, BW) Lectures  Pediatric cardiac history (BW)  Pediatric cardiac physical exam (BW)  Murmurs and heart sounds (BW)  Kawasaki’s Disease (TS)  Pulmonary Hypertension (EB)  Acquired heart disease (NA) Mentoring  Residents (NA, EB, TS, BW):  Resident: Caleb Hentges – PGY2

 Resident: Tara Robare – PGY2  Resident: Jessica Barnes - PGY2  Resident: Joseph Presson – PGY2  Resident: Rebecca Gerhmann – PGY2  Resident: Kristin Stuive – PGY2  Resident: Taryn Raschein – PGY2  Resident: Nathaniel Nelson – PGY2  NP Student: Kimberly Strebell  Adult Cardiology Fellows (NA, EB, TS, BW): Dr. Maheedhar Dedela

CME Lectures  Various topics in pediatric echocardiography for sonographers (TS, BW, NA, EB)  Adult Congenital Heart Disease, Part II  Adult Congenital Heart Disease, Part I Programs  Director, Congenital Cardiac Catheterization Laboratory (EB)  Director, Pediatric Cardiology Residency Elective (BW)  Director, Adult Cardiology Fellowship, Pediatric Cardiology Elective (BW)

Scholarly Activity Publications  Kimberly Strebell – NP Student

Clinical Service New Clinics/Programs/Outreach Outreach  Sheldon, Dakota Dunes (NA), Aberdeen, Pierre, Worthington (TS), Watertown, Mitchell, Brook- ings (BW) Patient Information  After Visit Summary (Meaningful Use) (TS)

Innovative Clinical Services  Implement protocols within EPIC best practices (TS, BW, NA, EB)  Team Building (TS)  Arrange for echo quality improvement with cooperation with Ann Arbor (TS)  Set up new EKG modality (MUSE) (BW)

Volunteer Service Medical School  Student Progress and Conduct Committee, University of South Dakota Sanford School of Medi- cine, 06/2015 – present (NA)  Pediatric Interest Group Meeting for Medical Students, University of South Dakota Sanford School of Medicine, 05/2016 (NA)  Medical Student Financial Aid Committee  University of South Dakota, Sanford School of Medicine, 11/2013- present (NA)

Hospital/Clinic  Technology and Clinical Informatics, Chairman, 7/2010- present (BW) University  Sanford Black Hills Pediatric Symposium Planning Committee, University of South Dakota San- ford Children’s Specialty Clinic, 08/2014 – present (NA)

Community  Mended Little Hearts (Family support group) (TS)

Professional  February 2015– Member, Editorial Board, Musculoskeletal Regeneration Journal (EB)

Other Memberships  The Society for Cardiovascular Angiography and Interventions (EB)  American Academy of Pediatrics, Fellow (NA, EB)  The American Heart Association (EB, TS)  The American College of Cardiology (NA, TS, BW)  The American Society of Echocardiography (TS)  South Dakota Medical Association (NA, TS, BW)

Child’s Voice/Child Abuse Dr. Nancy Free, Division Chief Division Members Brooke Jones, MD KIrsten Persson, PAC Shelly Hruby, CNP Child’s Voice Department Members: 3 Forensic Interviewers, 2 Nurses, 2 Child Advocates, 2 Family Advocates, 1 Patient Access (shared), 1 Department Director (shared), and 1 Department Assistant.

Child’s Voice is a nationally accredited Child Advocacy Center that provides medical evaluations for children who may be victims of abuse and neglect. Evaluations are provided in the inpatient and outpatient setting. Children are referred by medical professionals, law enforcement and Child Protection Services. Evaluations are performed utilizing a multidisciplinary approach so as to avoid further trau- matizing children by the systems designated to help them.

Services provided by Child’s Voice include:  Medical evaluations for potential maltreatment for children from birth through age 18, and for developmentally delayed adults when requested. Evaluations include Forensic Interviews for children developmentally able to participate, generally beginning at age 3 years.  Family consultation  Advocacy  Crisis counseling  Expert testimony regarding child maltreatment in state, tribal, and federal courts is provided by medical providers and forensic interviewers.  Foster Care Clinic : Children in out of home placement receive comprehensive evaluations including review of gathered medical records, developmental screen, mental health screen, vision and hearing screens, dental assessment with application of fluoride varnish when appropriate. Comprehensive report is available to primary provider. Referrals for indicated follow up are made in conjunction with primary provider.

Teaching: Medical Students Pillar 1  Pillar I students spend days at Child’s Voice. Pillar 2  1 Pillar 2 student for LIC pediatric subspecialty Pillar 3  Students participate in child abuse learning by spending 4-16 hours at Child’s Voice through the “Health Care for the Underserved” rotation, and through involvement with inpatient SCAN consults Lectures  Lectures to Pillar I Class on Child Maltreatment topics: Adverse Childhood Experiences, Physical Abuse, Abusive Head Trauma, Sexual Abuse, Neglect, Intimate Partner Violence, Medi- cal Child Abuse, and Mandated Reporting.

Healthcare Profession Students  Physician Assistant USDSSOM classes receive 8 hours didactic training on child abuse and neglect, mandatory reporting  Nursing classes at University Center: 2 hours didactic training on child abuse and neglect, mandatory reporting  Nurse Practitioner students: 3 hours didactic training on child abuse and neglect, mandatory reporting  Lake Area Technical Nursing Students – Clinic Preceptorship Site, Child’s Voice Outreach, Wa- tertown, SD

Undergraduate / Graduate Students  University of South Dakota Family Violence Class – Recognition and Response to Child Abuse, Adverse Childhood Experiences, Mandated Reporting, spring and fall semesters  University of Sioux Falls Graduate Students – ACEs, Minimal Facts, Recognizing and Respond- ing to Child Maltreatment.  University of Sioux Falls Nurse Practitioner Honors Course : Childhood Trauma  RISE UP student from LEND Program provided internship at Child’s Voice  BSW student provided internship at Child’s Voice

Residents Electives  Pediatric Residents – four residents did block rotations at Child’s Voice  Center for Family Medicine Residents – six residents spent 1 -2 days at Child’s Voice

Lectures  Four noon lectures on child maltreatment topics

Mentoring  Development of Children’s Day at the Capitol in partnership with SD AAP Chapter and Center for the Prevention of Child Maltreatment – residents instructed re advocacy and legislation.

CME  Child Maltreatment Grand Rounds: quarterly presentations on topics pertinent to child maltreatment awareness, response, and prevention.  19th Annual Community Response to Child Abuse – CME presentations by Child’s Voice: a. No Hit Zone b. Understanding and Addressing Maltreatment of Children with Disabitlites c. ABC’s of CAC’s and Child Maltreatment  Sanford Black Hills Pediatric Symposium – CME Presentations by Child’s Voice: a. Abusive Head Trauma b. Child Sexual Abuse

Clinical Service  Watertown Outreach Clinic: Child’s Voice services are provided at Sanford Clinic in Watertown, SD in a regional multidisciplinary team setting. 2019-2020 is the third year of the three year pilot program which is part of the 10 year plan to end child maltreatment in South Dakota. Partner- ship with Center for the Prevention of Child Maltreatment will assist in development of other regional multidisciplinary teams in South Dakota. The REACH (Respond, Educate, Advocate, Counsel, Heal) Team includes professionals with child maltreatment expertise on site in each of these disciplines: medical, forensic interviewing, law enforcement, child protection, mental health, advocacy. South Dakota is a rural state. Children may need to travel more than 200 miles to access appropriate medical care, forensic investigation tools and counseling. The child may be required to visit several communities to receive all services needed and the family may find little support while navigating the system. The core tenet of the regional MDT is to provide one place within a 2 hour drive where the child can have a medical exam, including a forensic interview, while investigators gather information from the family. The goal is to reduce the distance traveled for services and better meet the needs of the child and family, while appropriately collecting evidence and conducting investigations. Collaborating partners include Child’s Voice, Child Advocacy Centers of South Dakota, The Center for the Prevention of Child Maltreatment at University of South Dakota, Department of Social Services Division of Child Protection, Division of Criminal Investigation, and Watertown Police Department. The development process includes 6 hour trainings for multidisciplinary team members in 13 counties in northeast South Dakota.  Refinement of Pediatric Forensic Evidence Kit for South Dakota distributed by Department of Health to better meet the needs of children who are potential victims of sexual abuse/sexual assault.

 Sexual Assault Nurse Examiner (SANE) trainings and participation in the state task force to address needs in South Dakota.

Volunteer Service Community  Center for the Prevention of Child Maltreatment- Board Member  Child Advocacy Centers of South Dakota- Board Member  East River Infant and Child Mortality Review Committee + Task Force Steering Committee  South Dakota East River Human Trafficking Task Force  Sexual Assault Response Team (SART) Steering Committee Member: Steering Committee ad- dresses sexual assault issues in community and identifies best practice policies and procedures.

Trainings for Multidisciplinary Team Agencies and Advocacy Agencies:  Court Appointed Special Advocates (CASA): Training provided quarterly for new staff and volun- teers  Sioux Falls Police Department New Recruits: Training provided regarding recognition and response to child maltreatment 6 times yearly  Sioux Falls Police Department School Resource Officers: officers trained regarding child maltreatment recognition and response  Department of Social Services Division of Child Protection: Training for new workers x 8 hours, three times a year in Pierre, SD on Child Physical Abuse; Abusive Head Trauma ; Child Sexual Abuse; Human Trafficking; Intimate Partner Violence; Neglect; Children in Foster Care ; Drug Exposed / Endangered Infants and Children; and Prevention

Professional Professional Membership  Center for the Prevention of Child Maltreatment- Board Member  Child Advocacy Centers of South Dakota- Board Member  East River Infant and Child Mortality Review Committee + Task Force Steering Committee  South Dakota East River Human Trafficking Task Force  Sexual Assault Response Team (SART) Steering Committee Member: Steering Committee ad- dresses sexual assault issues in community and identifies best practice policies and procedures.

Other Child’s Voice Maltreatment Awareness/Prevention Initiatives Abusive Head Trauma – The Period of PURPLE Crying  Support provided to hospitals with newborns regarding program fidelity; Education is provided regarding normal infant behaviors to high school students, child care providers, and community members  Henry’s Run is a 5k run/walk every April to raise dollars and awareness for child abuse prevention. No Hit Zone (NHZ)  A ‘No Hit Zone’ is an environment in which no adult shall hit a child, no adult shall hit another adult, no child shall hit an adult, and no child shall hit another child. The purpose of this program is to create and reinforce and environment of comfort and safety for patients, families, and staff working in our facility. The program provides staff tools to deescalate and respond to aggression in the workplace, and education regarding positive parenting techniques, and the negative effects of corporal punishment.  Child’s Voice is a No Hit Zone; instruction and support provided to agencies/departments institut- ing NHZs.

ENOUGH Abuse Campaign  Child’s Voice trainers provide educational information to professionals, parents, youth, and other concerned individuals regarding preventions of sexual abuse.

ACEs and Resiliency  Child’s Voice trainers provide education regarding adverse childhood experiences and resilience to professional and community audiences.

Critical Care Dr. Jody Huber, Division Chief Division Members Joe Segeleon Mir Ali Benson Hsu Lesta Whalen Gokhan Olgun Ashley Sandeen

Teaching Medical Students Pillar 1  Benson Hsu: Cardiovascular Team Based Learning (TBL): Shock Pillar 2  Benson Hsu: Triple Jump  Jody Huber: Friday Academy Pillar 3  Lesta Whalen: Teaching during rounds (chalk talk), scheduled lectures while on elective  Jody Huber: PICU Sub-Internship Rotation Director  Benson Hsu: Transitioning to Residency Morning Report, Transitioning to Residency Journal Club, Transitioning to Residency Lecture: Patient Safety  Mir Ali: Involved with teaching medical students rotating in PICU  Joe Segeleon: HRO Characteristics. Presented to Health Policy Medical Student Focus Group. Sanford School of Medicine at the University of South Dakota. Sioux Falls, South Da- kota. February 2020 Mentoring Ashley Sandeen  Morgan Sorenson, MSIII  Natalie Walter, MSIIV Benson Hsu  D. Arendt (M4) Scholarship Pathway  D. Hegdahl (M4) Medical Student USD Jody Huber  Karina Ortman, MSIII Mir Ali  Laura Rezac, Medical Student USD  Emily Yoon, Medical Student USD  Kayla Munger, Medical Student USD  Ali Haines, Medical Student USD  Mentored the above mentioned students in creating and implementing this research survey de- signed to evaluate parent/guardian satisfaction with Nitrous oxide gas use for pediatric sedation during Botox injection, voiding cystourethrogram (VCUG), intravenous catheter placement, and other simple outpatient procedures. Parents’/guardians’ general understanding of the sedation method and procedural logistics were surveyed and their satisfaction with the child’s level of comfort, procedure recovery time, and overall satisfaction was assessed. Each of these compo- nents was rated on a scale of 1-10 with 1 being dissatisfied and 10 being satisfied. The project collected data on approx. 50 patient encounters and analyzed data. The results were used to conclude Nitrous oxide is good sedative to help improve patient satisfaction during pediatric se- dations. Healthcare Profession Students Joe Segeleon Panel Discussion. High Reliability Characteristics and SAFE. Nurse Residency program.

Undergraduate Students Benson Hsu SDSU Freshman Seminars in Mathematics: Analytics for the Healthcare Graduate

Graduate Students Benson Hsu U of Pennsylvania Wharton School of Business: Healthcare Analytics

Residents Lectures Ashley Sandeen  Pediatric Resident Core Curriculum 08/2019, 08/2020--Respiratory Failure  Case-based lectures in the PICU Benson Hsu  Bedside Chalk Talk on PICU/Sedation Rotations  Core Lectures: Mechanical Ventilation - Let's Build a Vent Lesta Whalen  Core Lecture series lectures – toxicology, TBI, ECMO  Attend PICU morning report 1-2x/month  PICU Mock Code Gokhan Olgun  PICU Resident Talks  Pediatric Airway Emergencies and respiratory failure  Pediatric Shock  Sedation and Analgesia  Status Epilepticus  Diabetic Ketoacidosis  Traumatic Brain Injury  Status Asthmaticus  Noon Lecture: Use of Sedatives in Pediatric ICU and Procedural Sedation. Pediatrics and Family Medicine Resident noon lecture. Sioux Falls, SD. 2019 Jody Huber  PICU Rotation Director  Pediatric Residency Associate Program Director  Senior Orientation, June 2019  Mock Codes  Noon Lectures:  “Shock”  “Upper & Lower Airway Disease” Mir Ali  Pediatric Shock  Sedation and Analgesia  Status Epilepticus  Traumatic Brain Injury  Blood Gas Interpretation  Acute Respiratory Failure  Mechanical Ventilation  Toxidromes Joe Segeleon  Management of children with DKA. Resident Lecture Series. Sanford Medical Center. Sioux Falls, South Dakota. August 2019.  Resiliency Panel. Resident Lecture Series. Sanford Medical Center. Sioux Falls, South Dakota. September 2019

Mentoring Ashley Sandeen Sarah Jackson, MS3

Lesta Whalen Mentor to one 2nd year resident

Jody Huber Bryan Blacker, PGY-3 Caleb Hentges, PGY-2

CME Lectures Benson Hsu  Pediatric Flight Nurses: Shock Lesta Whalen  Flight team lectures – Metabolic crisis, near drowning, Pediatric Arrhythmia  RN - ABG and X-ray Interpretation Jody Huber  Sanford ED Nursing Orientation: “Pediatric Upper & Lower Airway Disease” and “Status Epilepti- cus”  ECMO Educational Series: “Disease Pathophysiology in ECMO: Respiratory and Cardiac Dis- ease”  Critical Care Nursing Education: “Blood Gas Interpretation & Radiology for Pediatric Critical Care Nursing”  Pediatric Flight Nurse Education Series: “Acute Liver Failure” and “Heatstroke”  Pediatric Nursing Education Series: “Congenital Heart Disease” Mir Ali  9/6/20-Presented CME lecture on Traumatic Brain Injury for Pediatric Flight Team Programs Ashley Sandeen  Brave Enough Summit 09/2020  SAFE Trainer training 02/2020 Lesta Whalen  ECMO CME lectures and wet labs monthly for MD, RN and RT. Mir Ali  ELSO Conference -online  ACLS Certification

Scholarly Activity Publications Ashley Sandeen  Research Aims to Guide Prevention, Recovery of ICU-Related Impairments. AAP News 07/2020. Benson Hsu Peer Reviewed Publications  Kuy S, Tsai R, Bhatt J, Chu QD, Gandhi P, Gupta R, Gupta R, Hole MK, Hsu BS, Hughes LS, Jarvis L, Jha S, Annamalai A, Kotwal M, Sakran JV, Vohra S, Henry TL, Correa R. Emphasizing Vulnerable Populations during COVID19. Acad Med. 2020 Jul 2. PubMed PMID: 32639264  Chu Q, Correa R, Henry TL, McGregor KA, Stoklosa H, Robinson L, Jha S, Annamalai A, Hsu BS, Gupta R, Patton DU, Mereno-Walton LA, Butts C, Chai C, Kuy S. Reallocating Ventilators During the COVID-19 Pandemic: Is it Ethical? Surgery. 2020. PubMed PMID: 32616345

 Kuy S, Gupta R, Correa R, et al (listed in co-author group). Best Practices for a Covid-19 Prepar- edness Plan for Health Systems. NEJM Catalyst Innovations in Care Delivery. April 30, 2020. https://catalyst.nejm.org/doi/full/10.1056/CAT.20.0108  Selya A, Johnson EL, Weber TL, Russo J, Stansbury C, Anshutz D, Griese E, Hsu BS. Smoking is associated with a higher risk of unplanned medical visits among adult patients with diabetes, using retrospective electronic medical record data from 2014 to 2016. BMC Health Serv Res. 2020 May 6;20(1):383. PubMed PMID: 32375742.  Ernst KD, Committee on Hospital Care. Resources Recommended for the Care of Pediatric Pa- tients in Hospitals. Pediatrics March 2020, e20200204; DOI: https://doi.org/10.1542/peds.2020-0204. PubMed PMID: 32205465. Papers and Commentaries  Axelsen K, Hsu BS. A coronavirus vaccine would solve a lot of problems — if we use it. The Na- tional Interest. May 15, 2020. https://nationalinterest.org/blog/reboot/how-help-ensure-peo- ple-use-coronavirus-vaccine-when-we-finally-get-one-154661  Axelsen K, Hsu BS. A coronavirus vaccine would solve a lot of problems — if we use it. Ameri- can Enterprise Institute AEIdeas. May 14, 2020. https://www.aei.org/health-care/a-coronavirus-vaccine-would-solve-a-lot-of-problems-if-we-use-it/  Health Innovators Fellows. This Pandemic has Exposed the Inequities of Our Nation. The Aspen Institute. April 3, 2020.https://www.aspeninstitute.org/blog-posts/pandemic-inequities-nation/  Hsu BS. Coronavirus Pandemic: The Two Front War: Your Letters to the Editor for March 22. Ar- gus Leader. March 20, 2020. https://www.argusleader.com/story/opinion/read- ers/2020/03/20/coronavirus-pandemic-two-front-war-your-letters-editor-march- 22/2889290001/ Peer-Reviewed Abstracts  Ardent DA, Hsu BS. Impact of Payer Status on Value of Care in Pediatric Diabetic Ketoacidosis Hospitalizations. 2020 Annual Research Meeting, AcademyHealth. Selected for a Poster Presentation. Lesta Whalen  Bills T, Davis-Keppen L, Meyer L, Whalen L, Cobalamin-C Methylmalonic Acidemia and Homo- cystinuria in Neonate Presenting as Persistent Pulmonary Hypertension Requiring Extracorpo- real Membrane Oxygenation, Neonatology Today, April 2019: 14(4); 10-13 (see attached PDF)  Huber JN, Olgun O, Whalen LD, Sandeen AR, Rana DT, Zenel JA. Learner Preference of Schedule Type Improves Engagement of Pediatric Residents: Results of a Mixed-Methods Anal- ysis. Medical Science Educator. Accepted, awaiting Publication. Gokhan Olgun  Huber, J.N., Olgun, G., Whalen, L.D. et al. Learner Preference of Schedule Type Improves En- gagement of Pediatric Residents: Results of a Mixed-Methods Analysis. Med.Sci.Educ.(2020). https://doi.org/10.1007/s40670-020-01036-6. Jody Huber  Huber JN, Berg AD, and Bula-Rudas F. Acute Necrotizing Encephalopathy due to Streptococcus pneumonia: An Uncommon Pathogen in a Devastating Disease. Pediatric Neurology. 2020; 108:126-127. DOI: https://doi.org/10.1016/j.pediatrneurol.2020.03.002.  D’Alessandro DM, Ryan MS, Paik S, Turner TL, Huber JN, Potisek NM, Fromme HB. An Anno- tated Bibliography of Key Studies in Medical Education in 2018: Applying the Current Literature to Pediatric Educational Practice and Scholarship. Academic Pediatrics. 2020; 20(5):585-594. doi:10.1016/j.acap.2020.01.012.  Frey TD, Waltz WF, Huber JN. Oral Albuterol Overdoes with Electrocardiographic Changes and Cardiac Ischemia. Consultant. 2019;59(11):343-344. Mir Ali Manuscript Submission “EVALI: Evolving Threat to Healthy Teens” .  Case report : Mentored Pediatric resident Jessica Barnes in compiling and submitting the above mentioned case report “EVALI: Evolving Threat to Healthy Teens” . The manuscript has been accepted by South Dakota Medical Journal and awaiting publication

 In Process : “ Use of Nitrous Oxide for Minimal Sedation in Pediatric Outpatients: A Survey Anal- ysis of Patient Experience and Parent/Guardian Satisfaction” .Mentored USD medical students in compiling data and submission of manuscript.

Grants Awarded Gokhan Olgun 2020-present University of South Dakota Sanford School of Medicine Training Aware (T-35 CHIRP) “Implementation and Assessment of a Hospital-Wide Pediatric Sepsis Early Warning Tool” Grant 5T35HD088383-03 Source: University of South Dakota Sanford School of Medicin PI: Gokhan Olgun, MD & Jody Huber, MD Students: Amber Veldman MS2, Shelley Feng MS Role: Mentor Dates: 8/17/2017 – 8/31/2020

Presentations National Benson Hsu  Leading in a Time of Crisis: Equity Centered COVID-19 Recovery; Aspen Institute, Washington DC  Clinical Effectiveness Research Innovation Collaborative; National Academy of Medicine, Wash- ington DC. Regional Lesta Whalen  Life Saving Technology: Science and Stories of ECMO  Sanford PROMISE: Teen Science Café Lecture  Congenital Heart Physiology: Pediatric Nursing Educations Series  ECMO for the Neonate: Perinatal, Neonatal and Women’s Conference Gokhan Olgun  Artificial Intelligence in Medicine. University of South Dakota Pediatric Grand Rounds. Sioux Falls, SD. 2020  Islamic Faith and End of Life. Life Cycle South Dakota Quarterly Conference Call. Sioux Falls, SD. 2020 Joe Segeleon  Zen and the Art of High Reliability. Fargo Sanford Improvement Symposium. Fargo, North Dakota. October 2019.  The Meaning Behind Screening: Getting Ahead of Cancer. Patient Safety: Morbidity and Mor- tality Rounds. Sanford Medical Center. Sioux Falls, South Dakota. November 2019.  Saying Nothing is Saying Yes. Key Aspects in Improving Team Function. Vermillion Medical Center. Vermillion, South Dakota. December 2019.

Posters Local Ashley Sandeen Pediatric Research Day 05/2019 Now I Know MY ABCs- Delirium Prevention and Screening in the Pediatric ICU Regional Ashley Sandeen  PI Symposium, Sioux Falls, SD 04/2019 Now I Know MY ABCs- Delirium Prevention and Screening in the Pediatric ICU  Integrating Progressive Mobility into the EMR in the PICU Benson Hsu  Shock and ECMO; SD EMS Annual Conference, Sioux Falls, South Dakota

Lesta Whalen  Elgersma B, Heiberger A, Huber J, Whalen L. Effects of Clonidine on Dexmedetomidine Wean- ing Following Long-term Sedation in Pediatric Patients.  Accepted to Sanford PI Fair, South Dakota Society of Health System Pharmacists and Midwest Pharmacy Residency Conference: All Cancelled due to Coronavirus

Clinical Service New Clinics/Programs/Outreach Mir Ali  Involved in planning & creating policies for new program (Nurse Administered Nitrous Oxide sedation

Innovative Clinical Services Ashley Sandeen  ABCDEF quality initiative in the Pediatric ICU- implementation of 3 new protocols a. Delirium Screening (CAPD) b. Extubation readiness testing protocol c. Early Mobility protocol Lesta Whalen  Assist with development of adult ECMO program – Ongoing Gokhan Olgun  10 weeks of Outpatient Sedation Service and 8 weeks of inpatient service duty.  50 inpatient calls in PICU. Jody Huber  10 weeks of Sedation Service & 8 weeks of inpatient PICU service duty with approximately 50 in- house calls per year. Mir Ali  Clinical Inpatient service weeks in pediatric ICU  Outpatient Sedation service weeks  Administration –Director pediatric Outpatient sedation services  Pediatric resident education

Volunteer Service Medical School Benson Hsu  Nominating Committee, Sanford School of Medicine, USD  Health Affairs Medical Informatics Committee, Sanford School of Medicine, USD  Department of Pediatrics Awards Committee, Sanford School of Medicine, USD Lesta Whalen  Medical school admission committee – 3-year appointment  WIMS: Mentoring Co-Chair Jody Huber  GME Committee  Faculty Development Committee  Medical Education Committee

Hospital/Clinic Ashley Sandeen  Resident Wellness Committee  PICU ABCDEF Committee  Sanford Quality Council Lesta Whalen  Critical Care Committee  ECMO Director

Gokhan Olgun  Infection Prevention Committee Member  Airmed Sioux Falls Pediatric Transport Director Jody Huber  Sepsis QI Project  CDI Pediatric Physician Lead Mir Ali  Director – Pediatric Outpatient Sedation Department  Pediatric Care Monitoring Committee  Anesthesia Monitoring Committee  Attendance at Provider Meetings, Faculty meetings and Grand rounds  Continued education for Nitrous machine use to pediatric outpatient nursing staff.  Involved with PICU PI projects Joe Segelon  Continue in role as VPMO of pediatrics. On July 1 assumed role of Executive Director of High Reliability and Quality Improvement. Responsibility for SAFE implementation and deployment as well as additional participation in risk events analysis.

University Ashley Sandeen  USD- WIMS Steering Committee- Mentoring Co-Chair Lesta Whalen  USD- WIMS Steering Committee- Mentoring Co-Chair Gokhan Olgun  Student Progress and Conduct Committee Member 2018-2020

Professional Ashley Sandeen  Abstract reviewer- AAP SOCC, 2019, 2020 Benson Hsu  Aspen Global Leadership Network (AGLN)  Methods and Data Council, AcademyHealth  MCCKAP Committee, Pediatrics, Society of Critical Care Medicine (SCCM)  SCCM COVID-19 Second Wave Planning Committee, Society of Critical Care Medicine (SCCM)  Chair-Elect of Executive Committee, Section on Critical Care (SOCC), AAP  Committee on Hospital Care (COHC), AAP  Disaster Preparedness and Response Champion, South Dakota Chapter, AAP Lesta Whalen  SCCM Pediatric Online Module Development  Program improvement SCCM  Article reviewer Pediatric Critical Care Medicine Journal  Sanford Critical Care Committee  Sanford Smart Pump Committee  SMART Women Secretary  ELSO Adult Assessment Question Writer Jody Huber  SCCM Critical Care Congress Abstract Reviewer  APA Educational Scholar’s Program Faculty Advisor, Cohort 9 Mir Ali  Member of Society of Pediatric Sedation  Member of Society of Critical Care Medicine

Community Ashley Sandeen SMART Women- Founding Member Mir Ali Attendance at Sanford SAFE training Teaching PALS courses at Sanford learning center.

Other Benson Hsu Journal Reviewer  Ad hoc Reviewer, Pediatrics  Ad hoc Reviewer, HealthCare: The Journal of Delivery Science and Innovation  Ad hoc Reviewer, BMJ (British Medical Journal) Open  Ad hoc Reviewer, NEJM (New England Journal of Medicine) Catalyst  Ad hoc Reviewer, Pediatrics in Review  Ad hoc Reviewer, Hospital Pediatrics Scientific Abstract Reviewer  Scientific Abstract Reviewer, Society of Critical Care Medicine Annual Meeting  Scientific Abstract Reviewer, American Academy of Pediatrics National Conference & Exhibition  Student Poster Reviewer, AcademyHealth Annual Research Meeting  Scientific Abstract Reviewer, AcademyHealth National Health Policy Conference Honors  Sioux Falls TEDx Speaker  Presidential Citation, Society of Critical Care Medicine  Aspen Health Innovators Fellow, Aspen Institute Administrative  Senior Advisor Data/Analytics, Sanford Health Plan

Developmental and Behavioral Dr. Carrie Kippes, Division Chief Division Members Erin Schroeder, APRN-CNP, Noelle McGee, APRN-CNP

Teaching Medical Students Lectures Developmental Milestones Lecture 5/26/20

Residents  PGY-2 Developmental Pediatrics Rotation  USD Child Psychiatry Fellow Rotation Lectures  2/26/20 Noon Conference: “Global Developmental Delay and Intellectual Disability”  3/27/20 Noon Conference: “Autism Spectrum Disorders”  4/16/20 Noon Conference: “ADHD”  4/20/20 Noon Conference: “Behavior Basics”

Clinical Service New Clinics/Programs/Outreach—Multidisciplinary Team Clinics  LEND Clinic with USD Center for Disabilities  Myelo Clinic/Spina Bifida Clinic at SCSC  Autism/ADOS Clinic at SCSC  New Early Childhood Team clinic at SCSC—started 9/2020  Early Childhood Team Clinic at Lifescape

Volunteer Service (Committees, leadership positions, etc.) Hospital/Clinic Employee Appreciation Committee

Community Testimony re: Early Child Learning Bill with SD State House Education Committee 2/24/20

Endocrinology Dr. Alaa Al Nofal, Division Chief Division Members Alaa Al Nofal, MD, John Shelso, MD, Kurt Griffin, MD, Karen Hanisch, CNP

Teaching Medical Students Pillar 1 Rebecca Buechler Pillar 2 Nicole Rogers Kelsey Westad Monica Bailey Morgan Schreiver Jack Vogel Victor Georgiev Brooklyn DeVries Zack Dockter Pillar 3 Elise Blaseg

Healthcare Profession Students Karen Hanisch Pharmacy Students Aerial Wenzel Khia Warzecha Shelby VanDriel Shanee Hanning SDSU Graduate Nurse Practitioner Student Ephram Bejiga University of Nebraska Medical Center Advanced Practice Nurse Practitioner Student Janelle VanDeGriend

Residents Jade Arrobas Anna-Lisa Martino Emelia Stille Ashiesa Bagwe Shehbeet Mangat Kyle Baum Jessica Barnes Lectures Dr. Al Nofal  Inpatient management of type I diabetes in pediatric patients. Pediatric residency noon lecture. August 2020. Dr. Shelso  Abnormal Puberty: CFM residents 11/26/19  Hypoglycemia: Ped residents 12/16/19  Disorders of Sexual Differentiation: Ped residents 12/20/19

Dr. Griffin  “The Sanford PLEDGE Study” Sanford Pediatric Resident Lecture, 3 September 2020.

Graduate Students Dr. Giffin  Genetics of Human Disease: Lectures and discussion sections on genetics of diabetes. April 2016, Nov 2017, Nov–Dec 2019

Scholarly Activity Publications Dr. Griffin  Radichev IA, Yoonb J, Scott DW, Griffin KJ, Savinov AY. “Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2- based chimeric antigen receptor.” Cellular Immunol. 2020. 358:104224. https://doi.org/ 10.1016/j.cellimm.2020.104224

Grants Awarded Dr. Griffin  “Sanford PLEDGE [Sanford Project Leveraging Differential Gene Expression against Type 1 Dia- betes].” 2020–2022.  Helmsley Charitable Trust: $1,307,375  Sanford Health: $1,088,000  1 R44 AI142905-03 NIH SBIR “Advancing a Candidate Human Polyclonal Anti-Thymocyte Glob- ulin Product Produced in Transchromosomal Bovine for Transplant Induction/Acute Rejection and T1D Therapy.” Sept 2020 – Aug 2021 Phase 2 SBIR Role: Co-investigator.  Total Direct Costs: $340,550 Submitted Clinical Research Protocols [all section members are investigaotrs on these diabetes trials] Active Protocols  “TrialNet Natural History Study of the Development of Type 1 Diabetes (TN-01).” NCT00097292 . Diabetes TrialNet. Griffin Site PI, April 2013 – Present.  “EXTEND: Preserving Beta-Cell Function with Tocilizumab in New-onset Type 1 Diabetes” NCT02293837. Immune Tolerance Network. Griffin Site PI, November 2014 – Present  “Type 1 Diabetes Extension Study (TIDES)” NCT02734277. Immune Tolerance Network. Grif- fin Site PI, July 2017 – Present  “CEP-304” multi-center, randomized, parallel, adaptive, controlled trial in adult and pediatric patients with type 1 diabetes using hybrid closed loop system and control (CSII, MDI and SAP) at home.” NCT02748018. Medtronic, Inc. Griffin Site PI.  “Intrexon AG019-T1D-101: A prospective, multi-center, Phase 1b/2a study to assess the safety and tolerability of different doses of AG019 administered alone or in association with teplizumab in subjects with clinical recent-onset Type 1 Diabetes Mellitus (T1D).” NCT03751007. Inrexon, Inc. Griffin Site PI.  “PROTECT: Provention Bio’s T1D Trial Evaluating C-Peptide with Teplizumab” NCT03875729. Provention Bio, Inc. July 2019 – Present, Griffin Site PI.  “Sanford PLEDGE [Sanford Project Leveraging Differential Gene Expression against Type 1 Dia- betes]. Helmsley Charitable Trust and Sanford Health. July 2020 – Present, Griffin Protocol PI. Protocols in start-up  “TN-25: RAPTOR: Rituximab Followed by Abatacept for Prevention or Reversal of Type 1 Dia- betes” NCT03929601. Diabetes TrialNet. Study-wide enrollment suspended pending COVID- 19 considerations. Griffin Site PI.  “TN-22: Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus” NCT03428945 Diabetes TrialNet. Opening Fall 2020 Griffin Site PI.

 “ACTIV-2/A5401 Adaptive Platform Treatment Trial for Outpatients with COVID-19 (Adapt Out COVID)” NIH/NIAID/DAIDS. Opening October 2020. Griffin Site PI.

Presentations National Dr. Griffin  “Bridging The Gap: Private–Non-Profit Partnerships to Advance Preclinical Drugs into Clinical Trials” Antigen Specific Immune Tolerance Summit 2020, Boston, MA, 26 February 2020

Clinical Service New Clinics/Programs/Outreach  Watertown, Aberdeen and Dakota Dunes, SD

Innovative Clinical Services Dr. Griffin  Population level screening for T1D autoimmunity (PLEDGE study)

Volunteer Service Medical School Dr. Al Nofal  Pediatric Clinical Competency Committee at Sanford Pediatric Residency Program Dr. Griffin  University of South Dakota, Department of Pediatrics Research and Education Committee, Janu- ary 2014–Present  USD Pediatrics Mentoring Committee: July 2015-Present

Hospital/Clinic Dr. Al Nofal  Sanford Children's Specialty Clinic Executive Committee  Sanford Children's Specialty Clinic Employee Appreciation Committee Dr. Griffin  Sanford Research IRB-3. April 2014–Present  Sanford Research Faculty Search Committee: April 2014–Present  Sanford Research Clinical Liaison Committee: April 2014–2016  Sanford Research Faculty Leadership and Promotions Committee: August 2016–Present  Sanford-Mayo pediatric symposium steering committee: 2016–Present  Sanford Enterprise Diabetes Council: 2016–Present  Sanford Research Pediatric COBRE Internal Advisory Committee: 2016–Present  Sanford Research Population Health COBRE Internal Advisory Committee: 2016–2019  Formal mentor of faculty: Santiago Valdez, MD, 2019– Present

Community Dr. Griffin  City of Sioux Falls Bicycle Committee: 2014-Present.  Safe Cycling Instructor (one of 5 in SD certified by the League of American Bicyclists): 2014-Pre- sent.

Professional Dr. Griffin  (Lawson Wilkins) Pediatric Endocrine Society: Co-Chair Diabetes Special Interest Group 2018 – Present.

 Helmsley Charitable Trust / Milken Institute: advisory board member for Type 1 Diabetes Screening program development.  Ad Hoc Peer Review for Journals  Journal of Clinical Endocrinology and Metabolism: 2004 – Present.  Endocrine-Related Cancer: 2004 – Present.  Molecular Endocrinology: 2009 – Present.  PLOSone: 2015 – Present.

General Pediatrics Aaron Zylstra, Division Chief Division Members MB2: Scott Henry, Barry Bauer, Michelle Schimelpfenig, Rita Rabenberg and Gulsah Olgun. 26th/Sycamore: Michelle VanBeek, Elizabeth Bauer, Shannon Carruthers, Ed Mailloux, Scott McKercher, and Jennifer Haggar. 69th/Louise: Donna Weinacht, Candice Nelson, Laura Whittington and Aaron Zylstra. 32nd/Ellis: Katie Larson and Kaylie Reece Brandon: Kassy Thorpe

Teaching Medical Students Pillar 1  Dr. Haggar teaches Pillar 1 students Pillar 2  Most of the general pediatricians teach students during Pillar 2. The list includes Reece, Larson, Nelson, Zylstra, Whittington, McKercher, L Bauer, Mailloux, VanBeek, Haggar, Carruthers, Henry, Schimelpfenig Pillar 3  Dr. Haggar taught Development to the medical students. Dr.s Zylstra, Whittington, Nelson, Car- ruthers, McKercher and Haggar have taught Pillar 3 students Lectures  Dr.s Schimelpfenig and Haggar gave lectures Mentoring  Dr. Schimelpfenig mentors medical students

Healthcare Profession Students  Dr.s Whittington, Zylstra, VanBeek, Haggar, Mailloux, McKercher, Schimelpfenig, Larson, B Bauer, Henry, L Bauer taught PA or NP students in the office.

Undergraduate Students  Dr. Henry, Haggar, B Bauer, Nelson, Schimelpfenig and Zylstra have had undergraduate students shadow them in the office.

Residents Lectures  Drs. Nelson, Zylstra, Weinacht, Whittington, Larson, Reece, Mailloux, Haggar, E. Bauer, Schimelpfenig, and Ashbaugh regularly give noon lectures on Primary Care pediatric topics to the pediatric residents. Mentoring  Dr. Mailloux was mentoring Dr. Nate Nelson.  Dr. Schimelpfenig is mentoring Dr. Rebecca Gehrmann. Rotations  Dr. Nelson is Director of Sanford Children’s Hospital Pediatric Residency Continuity Clinic. Dr. Zylstra, Dr. Weinacht, Dr. Nelson and Dr. Whittington regularly supervise residents in this rotation.  Dr. Mailloux is Director of Sanford Children’s Pediatric Residency Outpatient rotation PGY- 1. Pediatricians at MB2 26th/Sycamore, and 32nd and Ellis supervise residents on this rotation.  Dr. Olgun is Director of Sanford Children’s Pediatric Residency Newborn Nursery Rotation. All the general pediatricians supervise residents on this rotation.  Dr. Nelson is Director of Sanford Children’s Pediatric Residency Outpatient rotation PGY-3. Dr. Zylstra, Dr. Weinacht, Dr. Nelson and Dr. Whittington regularly supervise residents on this rotation.

 Dr. Mailloux is Director of Sanford Children’s Pediatric Residency Acute Illness rotation PGY- 1. All the MB2, 26th/Sycamore, and 32nd and Ellis general pediatricians regularly supervise residents on this rotation.

Clinical Service  New Clinics/Programs/Outreach: Dr. Zylstra is doing outreach in Orange City, Iowa. Dr. Mailloux is the medical director for Children’s Inn and Children’s Home.

Volunteer Service Medical School  Dr. Barry Bauer is on the AOA committee.  Dr. Carruthers is on the Alumni Relations Council.  Dr. Schimelpfenig is on the medical education, Integration Sub-Committee, clerkship director’s committee and is the Pillar 3 Director and Dean of the Sioux Falls Campus.

Hospital/Clinic  Dr. Weinacht is a member of the Sanford Hospital/University of South Dakota Pediatric Resi- dency Competency Committee  Dr. Zylstra is Chief of Pediatrics for the Medical School  Dr.s Nelson and Dr. Zylstra are on the Physician Executive Council for Sanford  Dr. Nelson is on the Clinic Executive Committee  Drs. Nelson and Larson are Co Department Chairs for General Pediatrics for Sanford Clinic  Dr. Zylstra is Chief of Pediatrics for Sanford USD Medical Center Hospital  Dr. Zylstra is Chair of the Pediatric Care Committee for Sanford Hospital  Dr. Nelson is Co-Chair of the Professional Committee for Sanford Health  Dr. Carruthers is a member of the Enterprise Clinical Practice Committee  Dr. Carruthers is a member of the Perinatal Committee  Dr. Larson is on the Neonatal Care Services Committee  Dr. Larson is on the Enterprise Immunization and Antimicrobial Stewardship Committee  Dr. Haggar is on the Sanford One Chart Patient Education Group  Dr. Haggar is a member to the Physician Compensation committee  Dr. VanBeek is on the Metabolic and Bariatric Committee

Community  Dr. Haggar is a youth group leader for her church and works with Compassion Childcare  Dr. Ashbaugh does foster care.  Dr. Weinacht is on the St Vincent de Paul Society  Dr. B Bauer has been Boy Scout Leader and Committee Chair  Dr. Carruthers is on the Board of Ambassadors for the American Cancer Society  Dr. Schimelpfenig is a volunteer in the Church Nursery

Professional  Dr. VanBeek is past Chief of Staff on the Medical Executive Committee at Lifescape  Dr. Zylstra is Chair of Infection Control committee at Lifescape .  Dr.s Haggar, Whittington, Larson, Reece, Mailloux, and have done multiple interviews for local new organizations  Dr. Schimelpfenig is the SD AAP Chapter President

Other  Dr. L. Bauer is the SD AAP Breastfeeding Coordinator

Genetics Dr. Laura Davis-Keppen, Division Chief Division Members Laura Davis Keppen MD, Isum Ward, MD Pediatric genetic counselors Lisa Ohden, Katie Burns, Shea Bonine, Cartney Knecht

Teaching Medical Students Pillar 2  Dr. Davis-Keppen has 1 pillar 2 student every 2 weeks Small Groups  Dr. Ward started the genetics interest group Mentoring  Dr. Davis Keppen mentors students through the Women in Medicine Mentor/Mentee program

Healthcare Profession Students  We have LEND students in the Down syndrome clinic and Fetal Alcohol Spectrum Disorders clinic.  Dr. Davis-Keppen, Dr. Isum Ward, Lisa Ohden, and Katie Burns are all faculty members with the Augustana-Sanford Genetic Counseling Graduate School Program. We serve as advisory board members of the master’s degree program for genetic counseling  We have 10 first year and 5 second year genetic counseling masters level students who have pediatric genetics rotations throughout the year. Lectures  Dr. Ward teaches lectures on intellectual disability to 1st year genetic counseling students and metabolic disorders to the 2nd year genetic counseling students.

Undergraduate Students  Dr. Davis-Keppen mentored an undergraduate student interested in medical school and genetics.

Residents  Pediatric residents and transitional residents regularly take the genetics elective. Lectures  Dr. Ward teaches three lectures per year to the pediatric residents, one two-hour lecture per year to psychiatry residents.

Scholarly Activity Publications  Fliedner A, Kirchner P, Davis-Keppen L, Ohden L, et al: Variants in SCAF4 cause a neurodevelopmental disorder in humans and drosophila and are associated with impaired mRNA processing. The American Journal of Human Genetics. 28 June 2020. PII S0002-9297(20)30228-7.  Shieh C, Ohden L, Davis-Keppen L, Mark-Pierson T et al : GATAD2B-associated neurodevelopmental disorder (GAND): genetic, clinical, and 3 molecular insights into a NuRD-related disorder 4.Genetics in Medicine. 2020 Feb 12.  Slavotinek A, Van Hagen M, Kalsner L, Pai S, Davis-Keppen L, Ohden L, Person R, Liu S, Weiss J: Jumonji domain containing 1C (JMJUD1C) sequence variants in six patients with autism, intellectual disability, and seizures. European Journal of Medical Genetics. 2020 Jan 16.  Vissers LELM, Kalvakuri S, de Boer E, Geuer S, Oud M, van Outersterp I, Kwint M, Witmond M, Kersten S, Polla DL, Weijers D, Begtrup A, McWalter K, Ruiz A, Gabau E, Morton JEV, Griffith Demurger F, Soler-Alfonso C, Li D, Bhoj E, Hayes I, Hamilton NP, Ahmad A, Fisher R, van den Born M, Willems M, Sorlin A, Delanne J, Moutton S, Christophe P, Mau-Them FT, Vitobello A, Goel H, Massingham L, Phornphutkul C, Schwab J, Keren B, Charles P, Vreeburg M, De Simone L, Hoganson G, Iascone M, Milani D, Evenepoel L, Revencu N, Ward DI, Burns K,

Krantz I, Raible SE, Murrell JR, Wood K, Cho MT, van Bokhoven H, Muenke M, Kleefstra T, Bodmer R, de Brouwer APM. De Novo Variants in CNOT1, a Central Component of the CCR4- NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevel- opmental Delay. Am J Hum Genet. 2020 Jul 2;107(1):164-172. doi: 10.1016/j.ajhg.2020.05.017. Epub 2020 Jun 17. PMID: 32553196; PMCID: PMC7332645.

Grants Submitted  Brain and Behavior Research Foundation NARSAD Young Investigators Grant  The Templeton Foundation

Presentations Dr. Davis-Keppen  10-22-19 Genetic hearing tests-ECHO parent talk  11-19-19 Disorders of sex development  11-26-19 Genetic evaluation of hearing loss Dr. Ward  9-6-20 Imagenetics Genomic Medicine Symposium -- “The Emerging Role of Chromosomal Copy Number Variants in Clinical Psychiatry”  2-27-20 Department of Pediatrics Grand Rounds – Care for the Patient with Achondroplasia

Clinical Service New Clinics/Programs/Outreach  Skeletal Dyplasia, Psychiatric Genetics  Dr. Davis-Keppen and Dr. Ward provide outreach clinic to Rapid City eight times per year

Innovative clinical services  Down syndrome, Fetal Alcohol Spectrum Disorders Clinic, Cleft Lip and Palate multidisciplinary clinics

Volunteer Service Medical School  Laura Davis-Keppen MD  Faculty Council 2018-present  Promotion and Tenure Committee 2018-present

Hospital/Clinic Dr. Davis-Keppen  Sanford Children’s Genomic Medicine Consortium, 2015-present

Community Dr. Davis-Keppen  Newborn Screening consultant for the South Dakota Department of Health  Advisory Board Committee member, SD HRSA grant Reducing Loss to Follow-up after Failure to Pass Newborn Hearing Screening, 2015-present  Advisory board member for the Masters Degree program for Genetic Counseling, Augustana University and Sanford Health Dr. Ward  Volunteer inspector for the Annie E. Casey Foundation Juvenile Detention Alternatives Initiative

Professional  Augustana/Sanford Genetic Counseling Program Dr. Davis-Keppen  South Dakota American Academy of Pediatrics EHDI Champion (Early Hearing Detection and Intervention)

Hematology/Oncology Dr. George Maher, Division Chief Division Members Kaelyn Wagner MD; Daniel Callaway MD; Ashlee Blumhoff PNP, Brianna Murphy DO

Teaching Medical Students Pillar 2 Anton Boggy Moan El Gayer Nicole Rogers Pillar 3 Hannah Schumacher Sarah Scott

Residents Tara Raschien MD Emelia Stille DO Joseph Presson DO Caleb Hentges DO Kristin Stuive DO Tara Robere DO Rebecca Gehrmann MD Jessica Barnes DO

Scholarly Activity Publications  Clausen, Obrtoi, Lynch, Maher, Ridgeway, Atiq. Extramedullary myeloid sarcoma with symptoms of acute pancreatitis mimicking pancreatic carcinoma. South Dakota Medicine, 2020 July 73(7): 305-7.  Lee, Platt, Weeks, Grace, Maher, Gauthier, Devanna, Vitali, Randolf, McDonald, Geha, Chou. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in patients with haploinsufficinency of SOCS1. Accepted for publication, Journal of Allergy and Clinical Im- munology.

Grants Awarded Great Lakes Hemophilia Foundation.

Presentations Local Maher  3/9/20, Cervical Lymphadenopathy, USD Family Medicine noon conference  6/19/20: Immune Thrombocytopenia, pediatric noon conference  8/31/20: Pediatric Hematology/Oncology in Primary Care, USD Family Medicine noon conference

Clinical Service New Clinics/Programs/Outreach Pediatric Hematology/Oncology, Aberdeen, SD

Volunteer Service Medical School Maher  Department of Pediatrics Vice-Chair  Grand Rounds Committee  Residency Committee Wagner  Associate Program Director, Pediatrics Residency

Hospital/Clinic Maher  Institutional Review Board #3, Sanford Research, voting member.

Professional Maher  Member American Medical Association, American Osteopathic Association Wagner  Principal Investigator, Children’s Oncology Group Murphy  Principal Investigator, Sickle Treatment & Outcomes Research in the Midwest  Member Histiocytosis Society, The American Society of Pediatric Hematology/Oncology, and The American Osteopathic Association Maher, Wagner, Murphy  Members, Children’s Oncolgy Group

Hospital Medicine Dr. Carl Galloway, Division Chief Division Members Vishnu Kanala, MD, FAAP Julie Mayo, DO, FAAP Jessica Olcott, MD, FAAP Elizabeth Peck, MD, FAAP Jennifer Reed, MD, FAAP Daniel Reynolds, DO, FAAP

Teaching Medical Students and Residents The pediatric hospital medicine division is the primary teaching service within the pediatric residency program, and is the only service in the department with 24-7 resident coverage. First year residents complete four 4-week blocks on our service, and PGY-2 and PGY-3 residents have two blocks each year, including both daytime and nighttime care. On our service, the residents have the opportunity to function as the primary patient care physician, with increasing autonomy as they progress through their training. In addition, family medicine residents complete one block with the hospitalists during their PGY-1 year, with the opportunity to return for elective rotations. Medical students in Pillar 2 receive two separate weeks of inpatient pediatrics during their mini-block experience, as part of the Longitudinal Integrated Curriculum. During this time, they receive direct teaching and supervision from hospitalists and residents, providing the pediatric residents the opportunity to serve as teachers. Pillar 3 students also have the opportunity to complete a 2- or 4-week rotation as a sub-intern, and we have had many of these students on our team. As a teaching service, all of our clinical care involves education with students and residents. Hospi- talists engage in teaching in a variety of modalities, including bedside teaching rounds and staffing, informal didactics on rounds and in a classroom setting, morning reports, and occasional noon conference lectures. We also regularly lead mock code scenarios with residents and students in the USD Simulation Center, to improve resident performance in difficult clinical cases.

Lectures  Fluids and Electrolytes (CG)  Handoffs and Communication (CG)

Mentoring  Assigned mentors, Sanford Children’s Pediatric Residency Program Aimee Koenig, MD, PGY-2 (JR)  Dr. Julie Mayo was selected for the Outstanding Mentor Award, given by the Department of Pe- diatrics, USD SSOM and Sanford Children’s Specialty Clinic

Scholarly Activity Publications  Clute J, Frey T, Reed JA. Visual Diagnosis: Button vs battery; Foreign Body Ingestions in Pediat- rics. Pediatrics in Review: In Press  Bula Rudas F, Olcott JL. Human and Animal Bites. Pediatrics in Review: 2018 Oct;39(10)490- 500.  Blindness and Loss of Gross Motor Skills in a Young Toddler. Pediatrics in Review: Accepted for Publication. (CG, VK, EP)  Book Section: (In Press) Rhabdomyolysis. In B. Bolick, K. Reuter-Rice, M. Madden, & B. Sev- erin, Pediatric Acute Care: A guide for interprofessional practice. St Louis, MO: Elsevier. (JR)

Presentations Local  “Culture of Comfort.” USD SSOM Pediatric Grand Rounds, August 2, 2018 (JR)

 “Add a Pinch of Salt? Hypotonic vs Isotonic Maintenance Fluids.” USD SSOM Pediatric Grand Rounds, September 6, 2018. (CG)

Posters National  Trying to thrive with your guts in the air. Pediatric Hospital Medicine national meeting, Seattle, WA, July 27, 2019. Caleb Hentges, PGY-2, Jennifer Reed. Other  Abstract Review, Clinical Conundrums presentations, Pediatric Hospital Medicine conference, sponsored by American Academy of Pediatrics. (CG)

Clinical Service New Clinics/Programs/Outreach  Drs. Kanala and Reynolds frequently assist with pediatric coverage in Aberdeen and Mitchell.

Volunteer Service Medical School  Admissions Committee, USD SSOM (JR)  Grand Rounds Committee (CG)  Residency Committee (all)  Program Evaluation Committee, Pediatric Residency Program (JR)  Clinical Competence Committee, Pediatric Residency Program (JR)  Inpatient rotation medical student clerkship director (including student skills lab, completing evaluations, rotation coordination) (JO)  Pediatric Residency Inpatient Rotation Director (JR, DR)  Mock Code leader (JR, EP, CG)  Pediatric Department Mentoring Program mentors (CG, JM, JR)

Hospital/Clinic  Executive Committee (JR)  Pediatric Care Monitoring Committee (CG, JM, DR)  Antimicrobial Stewardship Committee (DR)  Pediatric Floor Committee (all, Chair- CG)  Sanford Children’s Enterprise Council (CG)  Clinical Practice Committee (CG)  PARS (Patient Advocacy Reporting System) Team Member (JM)  Pharmacy and Therapeutics Committee (CG)  Adult Care Monitoring Committee (CG)  Sanford Leading the Way (CG)

Community  United Way Community Impact Team (JR)  Pediatric Advanced Life Support instructor (JR, EP)  Volunteer Scout Leader (DR)  Coach for Let Me Run and Girls On The Run (programs through EmBe and Sioux Falls School District) (EP)  Make A Wish (EP)

Professional  American Academy of Pediatrics (all)  Society of Hospital Medicine (CG, JO, JR)  Appointment as Fellow in Hospital Medicine (CG)  South Dakota State Medical Association (all)  Pediatrics In Review Editorial Board Fellow (JR)

 Pediatrics Review and Education Program (PREP) Self-Assessment Editorial Board member (JR)

Other Performance Improvement projects involving all hospitalists:  Text Paging: to improve communication between nurses and physicians using a new paging system. Goal is to improve nursing satisfaction with response times while allowing residents to better prioritize tasks and minimize trips into and out of a patient’s room while trying to provide patient cares. (Team leader: JO)  Rounding Checklist: Goal is to improve and enhance the value and safety of patient care by utilizing a rounding checklist as a reliability tool that will aid in adherence to quality initiatives and encourage appropriate use of resources. (Team leader: CG)  Neonatal Fever: to develop an evidence-based algorithm and guidelines for management of neonatal fever. Interdisciplinary project including Emergency Department and Pediatric Infectious Diseases to review and modify current guidelines. (Team leader: VK)  Patient Experience Initiative: Goal is to improve patient and family experience and care of children at Sanford Children’s, including hospital and clinic, through an interdisciplinary approach. (Team leader: CG)  Sepsis Initiative: Goal is to improve recognition and early intervention in patients with sepsis in the emergency department and hospital. (Team leader: CG)  Pediatric Inpatient Pathways for Asthma (PIPA): Multi-site quality improvement project sponsored by the American Academy of Pediatrics (AAP) Value in Inpatient Pediatrics (VIP) network. Goal: to improve the care for pediatric patients hospitalized with asthma. (Team leader: DR)

Infectious Diseases Dr. Fernando Bula Rudas, Division Chief Division Members Santiago Lopez, MD and Fernando J. Bula-Rudas, MD

Teaching Medical Students Pillar 2 Bula and Lopez  Michael Wallum  Landon Olson (visiting med student)  Matthew Lommen  Natalie Walter  Mona El-Gayer  Megan Sommers Pillar 3  Austin Eggers  Tyler Sternhagen  Ethan Nemmers Lectures Bula  NBME pediatric review for Pillar 2 students  Discussing racial microaggressions in healthcare. Latino Medical Student Association. University of South Dakota Sanford School of Medicine. Sioux Falls, SD. October 1, 2019. Small Groups Bula  Triple jump cases: McKayla Wieczorek, Brendan Weschler Mentoring Bula  Mckayla Wieczorek  Brendan Weschler Lopez  Palmer Geralyn, Kooima Travis; VanHove, Christopher and Withrow, Landon Project: American Indian children outcomes during lower respiratory tract infection Highlights: Poster presentation at IDWeek 2019, Washington DC;  Travel Award: Travis Kooima and Christopher Van Hove received T. Denny Sanford Pediatric Fellowship Travel Support Award to attend the IDWeek 2019.  Claire Porter and Riley Paulsen (MD-PhD student): Project: American Indian children rate of vaccination

Residents Electives Bula and Lopez  Rebecca Gehrmann, PGY-2  Caleb Hentges, PGY-2  Kristin Stuive PGY-2  Tara Robare, PGY-2  Joseph Presson, PGY-2

Lectures Bula  COVID-19 update. Pediatrics noon conference. University of South Dakota Sanford School of Medicine. Pediatrics Residency Program. Sioux Falls, SD. March 26, 2020. Lopez  Fever of Unknown origin, Neonatal Infection and Musculoskeletal infection

CME Lectures Bula  Common antibiotic usage in the acute care setting. South Dakota Physician Assistants Confer- ence. Sioux Falls, SD. September 13, 2019.

Scholarly Activity Grant Submitted Bula and Lopez  DaCCoTa Pilot-COVID-19: Comparison of antibodies against SARS-CoV-2 in cancer and non- cancer pediatric patients in South Dakota Lopez  Seqirus: Comparison of Inactivated Cell based vs Egg based Influenza vaccine Pfizer: Evaluation of Streptococcus pneumonia colonization and COVID-19

Presentations Local Lopez  Grand Round: Native American children and lower respiratory tract Infection International Lopez  COVID-19 Immune Response, Argentinean Pediatric Infectious Disease Society (Guest Speaker)

Posters National Bula  The Society for Healthcare Epidemiology of America (SHEA) Spring 2020 Decennial Confer- ence. Atlanta, GA. April 2020. Improving Appropriate Testing for Clostridium difficile Infection: Update on Sustainability of a Quality Improvement Project. International Lopez  IDWeeK 2019, Washington DC. Lopez SMC, Weber Z, Palmer G, Kooima T, Bula-Rudas F, Chatterjee A, Increased severity of lower respiratory tract infection among Native American compared with non-native American children.

Clinical Service New Clinics/Programs/Outreach  Peds ID Telehealth during COVID pandemic

Innovative clinical services  Administration of routine catch up immunizations in patients  Travel clinic. Administration of vaccines in specialty clinic.

Vaccine clinical trials:  Janssen RSV 2002. CROCUS. Children’s RSV Outcome Clinical Study. Active.  Medimmune RSV D5290C00004. MELODY. A Phase 3 Randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of MED18897, a monoclonal antibody with an extended half-life against RSV, in healthy late-preterm and term infants. Active.  Merck NPMK7625A. A phase 1, open-label, non-comparative, multicenter clinical study to evaluate the safety, tolerability, and pharmacokinetics of ceftolozane/tazobactam in pediatric participants with nosocomial pneumonia. Active.  GSK RSV PED-002. RSV investigational vaccine in RSV-seropositive infants aged 12-23 months. Glaxo-Smith-Klein. Active.  PCORI. Kawasaki Disease comparative effectiveness trial. Active.  GSK Meningococcal B V72_57. Safety and immunogenicity of GSK meningococcal group B vaccine and 13-valent Pneumococcal Vaccines administered together with routine infant vaccines in healthy infants. Active.  Pfizer Pneumococcal C3571002. A phase 2, randomized, open-label trial to evaluate the safety and immunogenicity of a multivalent pneumococcal conjugate vaccine given with, or separately from, 13-valent pneumococcal conjugate vaccine in healthy infants. Closed for enrollment.  Moderna hMPV-PIV3 mRNA-1653-P102. Safety and immunogenicity of mRNA-1653, a com- bined human Metapneumovirus (hMPV) and Parainfluenza virus typ 3 (PIV3) Vaccine, in healthy adults, and children 12-36 months of age with serologic evidence of prior exposure. Active.  Pfizer Pneumococcal B7471011 (20-Valent). A phase 3, randomized, double-blind trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine in healthy infants. Active.

Volunteer Service Bula Professional  Assistant professor of pediatrics. USD Sanford School of Medicine  Pediatric Clerkship director  Antimicrobial Stewardship Committee. University of South Dakota Sanford School of Medicine. Medical Center. Sioux Falls, SD. August 2016. Active member.  Pediatric Antimicrobial Stewardship Committee. Sanford Children’s Hospital. Sioux Falls, SD. August 2016. Co-founder and active member.  Infection Prevention Committee. Sanford Health University of South Dakota Medical Center. Sioux Falls, SD. August 2016. Active member.  Sanford Children’s Hospital Infection Prevention Committee. Sanford Children’s Hospital. Sioux Falls, SD. August 2016. Active member.  Pediatric Residency Committee. Pediatric Residency Program. University of South Dakota San- ford School of Medicine. Sioux Falls, SD. August 2016. Active member.  Sioux Falls Region Immunizations Committee. Sanford Health University of South Dakota Medi- cal Center. Sioux Falls, SD. August 2016. Active member

Lopez Medical School  Assistant Professor, University of South Dakota, Sanford School of Medicine, SD

Hospital/Clinic  Chair of the comprehensive Unit-based Safety program for central line infection reduction; San- ford Health.  Co-Director of Antimicrobial Stewardship, Sanford Children’s Hospital, Sioux Falls, SD.

Community  External Advisor for the Sioux Falls School District Professional: Editorship  Journal of the Pediatric Infectious Diseases Society and AAP Pediatrics

Neonatal/Perinatal Medicine Dr. Suzanne Reuter, Division Chief Division Members Stephen Messier MD, Associate Professor of Pediatrics, Medical Director of the NICU, Pediatric Lead Physician Michelle Baack MD, Associate Professor of Pediatrics, Associate Physician-Scientist at Sanford Re- search Lauritz Meyer MD, Assistant Professor of Pediatrics, Director of Neonatal Transport, Director of NICU rotation for medical students Jessica White MD, Assistant Professor of Pediatrics, Director of NICU rotation for Pediatric Resi- dents, Clinical Investigator at Sanford Research Laurie Hogden MD, Assistant Professor of Pediatrics, NIC Quality Improvement Chair, NICU Follow Up Clinic Director Akram Khan MD, Clinical Associate Professor of Pediatrics Jacquelyn Grev MD, Assistant Professor of Pediatrics Baiba Steinbrekera MD, Assistant Professor of Pediatrics Kathryn Anderson MD, Assistant Professor of Pediatrics Larry Wellman MD, Professor of Pediatrics – Retired from clinical duties Dennis C. Stevens MD MS, Professor of Pediatrics – Retired from clinical duties David Munson MD, Professor of Pediatrics – Retired from clinical duties

Clinical Care The members of the Section of Neonatal/Perinatal Medicine remain actively involved in the clinical management of 810 neonates admitted to the Boekelheide NICU in 2019. This includes the ongoing medical management of neonates in the NICU 24 hours per day, attendance at high-risk deliveries, prenatal consultation for parents of high-risk neonates, telephone consultation for referring physicians and includes the services provided by Dr. Messier as the medical director of the Boekelheide NICU and Dr. Meyer’s management of the Sanford Sioux Falls Neonatal Transport Program. Neo- natologist coverage for the NICU currently involves three rounding attending physicians, seven days per week. The group provided medical management for approximately 200 neonatal transports last year. Nine members of the section (Drs. Munson, Khan, Hogden, Meyer, Messier, White, Grev, Steinbrekera, and Anderson) staff the weekly NICU Follow-up Clinic for high-risk graduates of the NICU. The neonatologists mentor LEND students, nurse practitioner students, and pediatric residents in the clinic. Dr. Hogden serves as the Director of the NICU Follow-up Clinic.

Sanford Childen’s Hospital provides ECMO capabilities to pediatric and neonatal patients on-site in the Pediatric Intensive Care Unit. This service became available to neonates as of August 2016. Dr. White has been instrumental in coordinating this practice change and has worked closely with the Pediatric ECMO team with the first patient cannulated August 2017. She serves on the institutional ECMO committee and as the NICU liaison, along with Dr. Steinbrekera.

Academics As demonstrated by the number of grants funded, publications, and national, regional and local presentations, the members of the section have been extremely productive academically. All members of the section have been actively involved in the Sanford School of Medicine.

All members of the section are active in teaching pediatric residents while on their NICU rotations. Dr. White serves as the liaison to the pediatric residency for the section. The section continues to host morning report for the residents three Wednesdays per month. All section members also teach/supervise family medicine residents completing their 2-week NICU rotation.

Each neonatologist is active in teaching medical students in the NICU. Students in Pillar 1 participate with shadowing experiences whereas interested students in Pillar 3 typically complete a sub internship in the NICU. Dr. Meyer is the liaison to the medical school for the section. Dr. Hogden

60 serves as a medical student Triple Jump faculty (Pillar 2 education) and serves as a medical student faculty advisor.

Dr. Messier founded a “boot camp” in 2013 for teaching the pediatric residents resuscitation and procedural skills, which continues on an annual basis. The boot camp includes Pediatric Residency faculty as instructors and many of the neonatologists participate in teaching stations. The boot camp is held in the Parry Simulation Center.

Whereas all members of the section are certified in the Neonatal Resuscitation Program (NRP), Dr. Hogden, Dr. Messier, Dr. Grev and Dr. White act as instructors for practicing physicians, residents, respiratory therapists, and nurses. Drs. Hogden, Messier, White, Reuter and Dr. Grev also provide simulation training for pediatric mock codes for family medicine and pediatric residents, and Dr. White coordinates this training. In addition, Drs. Hogden and Messier serve as the advisors for the neonatal nurse practitioner skills validation lab.

The neonatologists participate in NICU RN education on a regular basis. Dr. Hogden and Dr. Grev have spoken regularly at the RN Professional Practice meetings providing education on our NICU outcomes. Dr. Hogden and Dr. Meyer are teaching Level 3 education courses through the Neonatal Orientation and Education Program (NOEP) for the new registered nurses in the unit.

Research Dr. Baack continues in a half-time clinical position and a half-time appointment at Sanford Re- search, where she is Associate Physician-Scientist. In addition to leading NRN studies, Dr. Baack’s projects include:  Feasibility of Cord Blood/Umbilical Cord Tissue Collection, Cryopreservation, Thawing, Cellular Analysis and Placental Tissue/Cellular Analysis. Sanford Research Principal Investigator  International Milk Bank Survey. Co-Investigator (PI, Simon Dyall, Bournemouth University, UK)  Registry for Perinatal COVID-19 Infections. American Academy of Pediatrics Section on Neona- tal-Perinatal Medicine. Sanford Principal Investigator  Identifying Genetic Causes of Rare Diseases. Sanford Research Sub-Investigator

Neonatal Research Network Sanford NICU is a satellite site with the University of Iowa for the Neonatal Research Network (NRN). The NRN is a National Institute of Health established consortium that conducts multicenter studies with the goal to improve outcomes for high-risk newborns including very low birth weight infants (VLBW) born <29 weeks gestational age. Several clinical trials have been initiated with enrollment ongoing in the Boekelheide NICU. Sanford Site Principal Investigator: Michelle Baack MD

Multiple members of the section are leads on various NRN studies. The following is a list of projects and Sanford Principal Investigators:

 Project Title: Survey of Morbidity & Mortality among High Risk Preterm Infants (GDB). Sanford Principal Investigator: Michelle Baack MD  Project Title: Darbepoetin to Improve Red Cell Mass and Neuroprotection in Preterm Infants. Sanford Principal Investigator: Michelle Baack MD  Project Title: Neurodevelopmental Effects of Donor Human Milk vs. Preterm Formula in ELBW Infants. Sanford Principal Investigator: Jessica White MD  Project Title: Milrinone for Congenital Diaphragmatic Hernia. Sanford Principal Investigator: Michelle Baack MD  Project Title: All Birth Cohort Study. Sanford Principal Investigator: Michelle Baack MD

 Project Title: Follow up Study. Sanford Principal Investigator: Laurie Hogden MD (Gold Standard Neurologic Examiner for all NRN Follow-Up Studies)  Project Title: Hydrocortisone for Bronchopulmonary Dysplasia. Sanford Principal Investigator: Larry Meyer MD  Project Title: Moderately Preterm Infants with Caffeine at Home for Apnea (MoCHA) Trial (Mo- CHA). Sanford Principal Investigator: Suzanne Reuter MD  Project Title: Management of the Patent Ductus Arteriosus in Premature Infants Trial (PDA Trial). Sanford Principal Investigator: Baiba Steinbrekera MD  Project Title: Budesonide with Surfactant for Bronchopulmonary Dysplasia. Sanford Principal Co- Investigators: Lauritz Meyer MD and Jacquelyn Grev MD  Project Title: Cycled Phototherapy: A Safer Effective Method to Control the Serum Bilirubin of Extremely Premature Infants? Sanford Principal Investigator: Baiba Steinbrekera MD  Project Title: Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): A Func- tion-Based Assessment and Management Approach. Sanford Principal Investigator: Jessica White MD  Project Title: Pragmatic, Randomized, Blinded Trial to Shorten Pharmacologic Treatment of Newborns with Neonatal Opioid Withdrawal Syndrome (NOWS). Sanford Principal Investigator: Akram Khan MD

Research and quality improvement are ongoing initiatives of the section and currently include the following group projects, led by Dr. Hogden as Chairperson of the NICU Quality Improvement Council:  Management of Asymptomatic Infants Exposed to Chorioamnionitis  Thickener Use with Feedings for Oropharyngeal Dysphagia  Reduction of Bronchopulmonary Dysplasia  Preventing progression of ROP  Prevention of Newborn Hypothermia in VLBW Infants  Dandle Roo Positioning Blanket and the Effectiveness of Phototherapy in the NICU

Research Mentoring of Undergraduate Students Michelle Carlson, University of Dallas, Irving, TX; Sanford Program for Undergraduate Research (2019). Transitioned to pursue her PhD in Biological Sciences at Notre Dame University Michelle Baack MD

Andrew Paulson, Augustana University; 2018-2019 Sanford Program for Undergraduate Research (SPUR); “Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Isolation Methods for Use in Cardiac Regenerative Medicine: Explant vs. Enzymatic Digestion” Michelle Baack MD

Research Mentoring of Graduate Students Claire Kittock, USD SSOM MD/PhD Training Program. Medical Student Research Program Michelle Baack MD

Eli J Louwagie, USD SSOM MD/PhD Training Program. “Mitochondrial Roles in Developmentally Programmed Heart Disease”  Highlights: First-author publication in Pediatric Research  4 co-authored papers in American Journal of Physiology - Heart and Circulatory Physiology, Nu- trients, International Journal of Molecular Sciences, and Frontiers in Endocrinology  Submitted first author paper to Cell Reports  Society for Pediatrics Research (SPR) MD-PhD Student Research Award Michelle Baack MD

Ruth Ellen Anderson, USD SSOM MD/PhD Training Program. “Dynamic Regulation of Vesicular Trafficking by Altered Sterol Homeostasis”  Dissertation Committee, Career Mentor: Michelle Baack MD Emily Storm, USD SSOM MD/PhD Training Program. “Potential Mechanisms of Nup155 in Cardiac Development and Disease”  Dissertation Committee, Career Mentor: Michelle Baack MD

Research Mentoring of Medical Students Sarah Scott MSIV and Kayla Munger MSIV. Research elective and authored manuscript. “Infant of a Diabetic Mother.” SD Medicine. Jul 2020, Vol. 73 Issue 7, p323-327  Jacquelyn Grev MD Maya Gogoi MSII. Research project to evaluate the role of steroids and adrenal insufficiency in VLBW infants. Single Center, Retrospective Case-Control Study to Determine Probability of adrenal Insufficiency in Very Low Birth Weight Infants. T32 CHIRP Grant Recipient  Jacquelyn Grev MD  Michelle Baack MD Nathan Whitsell MSIV. Research Elective and authored manuscript. “Craniosynostosis – A Review for Providers.” SD Medicine. In Press  Lauritz Meyer MD Michael Schroeder MSIV. “Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up." SD Medicine. In Press  Jessica White MD Claire Kittock, USD-SSOM MD/PhD Training Program. “Influence of Prenatal Exposure to Maternal Diabetes on hu-MSC Proliferation and Differentiation”  Mentor: Michelle Baack MD Jaelin Otta MSIV, Natalie Walter MSIV, Morgan Sorensen MSIV, Mona ElGayar MSIV. “Dandle Roo Positioning Blanket and the Effectiveness of Phototherapy in the NICU”  Baiba Steinbrekera MD

Research Mentoring of Pediatric Residents Emelia Stille DO. “Lactational Exposure to High-Fat Diet and Metformin Incites Myocardial Lipid Ac- cumulation in Adult Male Offspring”  Michelle Baack MD Emilia Stille DO and Annie Martino MD. Assisting in the implementation of Eat-Sleep-Console Initia- tive in the NICU  Jessica White MD

Publications Grev, Jacquelyn, Munger, Kayla M, Scott, Sarah M. “Infant of a Diabetic Mother.” SD Medicine. Jul 2020, Vol. 73 Issue 7, p323-327

Jakubovskis M, Kojalo U, Steinbrekera B, Auzins J, Kirilovas D, Lietuvietis V. “Renal Cell Carci- noma Trends in Latvia: Incidence, Mortality, and Survival Rates. Population-Based Study.” Cent Eu- ropean J Urol. 2019;72(4):344-350

Whitsell N, Meyer L. “Craniosynostosis – A Review for Providers.” SD Medicine. In Press

Wang Z, Neupane A, Vo R, White J, Wang X, and Marzano, SY. “Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants.” Frontiers in Microbiol- ogy. 26 May 2020. PMID: 32528425. PMCID: PMC7264382 Schroeder, M. and White JR. “Neonatal Abstinence Syndrome: Prevention, Recognition, Treatment, and Follow-up.” In Press

Hogden L, Munger K and Duffek S. “Neonatal Respiratory Distress.” SD Medicine. In Press

Preston CC, Larsen TD, Eclov JA, Louwagie EJ, Gandy TCT, Faustino RS‡, Baack ML‡. ‡Joint senior authors. “Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways That Regulate Cardiac Metabolism and Cell Fate in Newborn Rat Hearts.” Frontiers in Endocrinology. 2020;11(677). doi: 10.3389/fendo.2020.570846

Dominguez EC, Heires AJ, Pavlik J, Larsen TD, Guardado S, Sisson JH, Baack ML, Romberger DJ, Nordgren TM. “A High Docosahexaenoic Acid Diet Alters the Lung Inflammatory Response to Acute Dust Exposure.” Nutrients. 2020 Aug 4;12(8):2334. doi: 10.3390/nu12082334. PMID: 32759853; PMCID: PMC7468878

Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore LA. “Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat.” Reprod Sci. 2020 Feb;27(2):631-643 PMID: 32046449

Tricia D. Larsen, Kyle Sabey, Alexis Knutson, Tyler C. T. Gandy, Eli J. Louwagie, Lothar Lau- terboeck, Kennedy S. Mdaki, Michelle L. Baack. “Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in Developing Cardiomyocytes by Sex Specific Mechanisms.” Int J Mol Sci. 2019 Jun 25;20(12). PMID: 31242551. PMCID: PMC6627740

Presentations Jessica White “How (and Why) to Integrate Research into a Busy Clinical Practice.” Presentation for Women in Science and Medicine Education Day. USD SSOM. October 15, 2019 Dorn K. and White J. "Case Report: Preterm Neonate with Abnormal Facies, Joint Contractures, and Respiratory Failure.” Oral presentation for USD SSOM 1st Annual Student Affairs Virtual Schol- ars Symposium. September 9, 2020

Laurie Hogden “Jaundice in the Neonate” Pediatric Residency Noon Conference

Michelle Baack “Neonatal Dermatology: Cause for Counsel or Concern?” Pediatric Residency Noon Conference

Akram Khan “Kernicterus” Pediatric Residency Noon Conference

Akram Khan “Infant with Severe Skeletal Anomalies, Altered Features and Arachnodactyly” Oral Presentation at Rady Children’s Hospital Genomic Consortium

Pediatric Academic Society; Philadelphia, PA. May 2nd, 2020. “Mitochondrial Transplantation Im- proves Cardiac Bioenergetics in Offspring of Diabetic Mothers Born with Cardiomyopathy.” Eli Louwagie*, Tricia Larsen, Angela Wachal, Michelle Baack. *Platform Presentation. BBS Travel Award. SPR MD-PhD Student Research Award for best abstract.

NHLBI Mitochondrial Biology Symposium: On Mitochondrial Networks and Energetics. Bethesda, MD. September 27th, 2019. “Mitochondrial Transplantation Improves Respiratory Capacity in Neo- natal Cardiomyocytes Exposed to Maternal Diabetes and High-Fat Diet.” E. Louwagie*, M. Baack. *Poster Presentation

Steve Messier “Respiratory Distress of the Newborn” and “Respiratory Support of the Sick New- born” Pediatric Residency Noon Conference

Entrepreneurship & Patents De la Puente P; Baack, M; Bhatacharya, S; Gandy, T and Calar, K. “Three-Dimensional Cross- Linked Scaffolds of Blood Plasma and Their Use.” Provisional Patent, 2019 and full patent submission June 13, 2020

Grants Project: “Mitochondria, Metabolic Plasticity and Cell Fate in the Developmental Origin of Fuel-Medi- ated Cardiomyopathy.” Center for Pediatric Research, Project 3. Principal Investigator: David Pearce. Project 3 Leader: Michelle Baack Role: Project 3 Lead Agency: NIH/NIGMS, Center of Biomedical Research Excellence (COBRE) - 2P20GM103620-06 $236,229/year 9/01/18-8/31/23

Project: NICHD Cooperative Multicenter Neonatal Research Network Principal Investigator: Edward Bell; Sub-I Michelle Baack (Satellite Site PI) Agency: NIH/NICHD, 2UG1HD053109-11, Subaward: W000910508 $9,119/year 01/01/17-03/31/20

Service In addition to clinical service, the members of the section are very involved in a variety of other forms of service including serving on a wide variety of hospital and medical school committees.

Dr. Baack Eunice Kennedy Shriver NICHD Strategic Planning Working Group Neonatal Research Network Steering Committee Society for Pediatric Research (SPR), Member Perinatal Research Society, Associate Member SD Medicaid Advisory Committee, Governor-Appointed position SD Medicaid P&T Committee, Governor-Appointed position Sanford Profile Clinical & Scientific Advisory Board Sanford Lorraine Cross Award Scientific Advisory Board USD SSOM Alumni Relations Council, Past President USD SSOM Pediatrics Residency Committee Sanford Investigational Review Board #3, Consulting Member Alpha Omega Alpha Associate Editor, American Journal of Perinatology Biology of Sex Differences, Reviewer Journal of Perinatology, Reviewer Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Reviewer Sanford Division Chief of Research, USD SSOM Department of Pediatrics

Dr. Khan NICU Picnic Organization Committee Sanford Children’s Genomic Consortium Project Neonatal Abstinence Syndrome Work Group Leadership Education in Neurodevelopmental and Related Disabilities (LEND) Opioid Education through Project SCOPE (Supporting Children of the Opioid Epidemic) with Extension of Community Health Care Outcomes (ECHO)

Dr. Hogden Seventh District SDSMA Member USD SSOM Student Financial Aid Committee USD SSOM Medical Education Committee Sanford Health Newborn Care Services Committee Vermont Oxford Network Team Leader/Services Administrator Neonatal representative to the Sanford Pediatrics Genetic Consortium Multi-Site Collaborative USD SSOM Medical Student Faculty Advisor - Jordyn Kreutzfeldt MSIV NICU Patient Experience Committee Sanford Children’s CDI Physician Champion

Neonatal Intensive Care Quality Improvement Committee (NIC QIC) Chair South Dakota Perinatal Association (SDPA) Board Member South Dakota Perinatal Association (SDPA) Planning Committee Pediatric Boot Camp Participant

Dr. Messier Newborn Services Committee, Chair Sanford Health Critical Care Committee Pediatric Care Monitoring Committee Sanford Health Anesthesia Monitoring Committee Sanford Health Perinatal QI Committee USD SSOM Pediatric Residency Clinical Competence Committee USD SSOM Pediatric Residency Committee SAFE High Reliability Organization Trainer Sanford Health Peer Mentor

Dr. Meyer Liaison to the Intermediate Care Nursery Liaison to Normal Newborn Nursery Sanford Perinatal QI Committee OB Floor Committee Neonatal Care Services Committee NICU Patient Experience Committee USD SSOM Alumni Relations Council Sanford Children’s CDI Physician Champion South Dakota Perinatal Association (SDPA) Board Member South Dakota Perinatal Association (SDPA) Planning Committee

Dr. Munson Sanford Health Credentials Committee Sanford Health By-laws committee USD SSOM Department of Pediatrics Promotion and Tenure Committee, Chair Mentor for middle school boys from church Pro Am International Golf Tournament Security Committee Clinical Teaching of Pillar 2 students and Pediatric Residents

Dr. Reuter USD SSOM Faculty Affairs Committee USD SSOM Assistant Dean of Medical Student Affairs for Pillar 2 and 3 (clinical years) USD SSOM Department of Pediatrics Research and Education Committee Alpha Omega Alpha AMC Council on Faculty and Academic Societies – USD SSOM Representative SD Medicine manuscript Reviewer The Banquet - community volunteer

Dr. White USD SSOM Pediatric Residency Clinical Competency Committee USD SSOM Pediatric Wellness Residency Subcommittee USD SSOM Pediatric Residency Recruitment Pediatric/Neonatal ECMO Committee (NICU Co-Liaison) NICU Infant-driven Feeding Committee Mock Code Committee Fetal Chart Committee USD SSOM Graduate Medical Education Committee USD Strategic Planning Task Force Neonatal Abstinence Syndrome Work Group

NICU Multidisciplinary Initiative – Read to Babies/Read-A-Thon AAP District VI Association of Neonatologists Board Sanford Research Clinical Investigator Invited Reviewer - American Journal of Perinatology

Dr. Steinbrekera Neonatal Intensive Care Quality Improvement (NIC QIC) Committee NICU ELBW Infant Committee Pediatric/Neonatal ECMO Committee (NICU Co-Liaison) Invited Reviewer – American Journal of Perinatology Medical Student Mock Interviewer for residency preparation Pediatric Residency Faculty Interviewer

Dr. Grev Neonatal Intensive Care Quality Improvement (NIC QIC) Committee Sanford Blood Product Transfusion Committee Pediatric Resident Advisor – Ariane Moffett DO

Dr. Anderson Neonatal Intensive Care Quality Improvement (NIC QIC) Committee NICU Graduates Annual Reunion Representative

Dr. Wellman Clinical teaching of Pediatric Resident

New Directions in 2021  We, as a section, continue to promote the use of human milk throughout the Sanford Enterprise.  Continued work with NICU staff in enhancing parent satisfaction scores for NICU services.  Maintain knowledge and adherence of current recommendations for the evaluation and treatment of COVID-19 exposed infants from maternal infection  Institutional practice change with implementation of Eat-Sleep-Console in treatment for neonatal opioid withdrawal which will include education of all NICU staff (nurses, therapists, physicians, NNPs).  Provide continued support for the numerous clinical research trials, including those new and ongoing projects associated with the Neonatal Research Network.  Make a concerted effort to focus on well-being and work-life balance amongst section members, to include organized time together as a section outside of work.  Our section continues to utilize Vermont Oxford Network Data, under the leadership of Dr. Hog- den, to Drive Quality Improvement. In 2021, our focus is on respiratory standardization in the NICU. In addition, the multi-disciplinary NIC QIC will continue with ongoing data collection in the evaluation of at-risk infants exposed to chorioamnionitis.

Palliative Care Dr. Daniel Mark, Division Chief Division Members Larry Fenton (MD) Pam Koepsell (CNS)

Teaching Medical Students Pillar 2  (Team) two medical students per year, rotating half-day every two weeks

Lectures  (Dan) 3/26/20 USD Medical School: transition to residency course “Communication Skills for Providers”

Small Groups  (Dan) Interdisciplinary Palliative Care (IPC) Seminar, organized by Life Circle South Dakota; weekly sessions each fall; containing medical, nursing, social work, pharmacy, and chaplain students

Healthcare Profession Students Lectures  (Pam) 4/14/20 Augustana genetics students “Perinatal Palliative Care”  (Larry) anticipated-10/23/20 USD physician assistant students “Pediatric Palliative Care”

Small Groups  (Dan) as noted above: Interdisciplinary Palliative Care (IPC) Seminar, organized by Life Circle South Dakota; weekly sessions each fall; containing medical, nursing, social work, pharmacy, and chaplain students  (Team) PA student rotated with PRISM Team for 1 week last year

Residents Electives  (Team) scheduled for 8 resident rotations this academic year

CME Programs  (Dan) Attended 2019 Annual Assembly of the American Academy of Hospice and Palliative Med- icine; also attended 2019 National Pediatric Hypnosis Training Institute fundamentals training seminar

Scholarly Activity Publications  (Larry) Fenton L: Clinical Hypnosis and Hypnotic Language in Pediatric Palliative Care. Na- tional Hospice Organization Pediatric E-Journal 56: 42-45, August 2019 https://www.nhpco.org/wp-content/uploads/2019/08/Issue-56-PART-TWO-Final.pdf

Presentations Local  (Dan) 1/24/19 pediatric grand rounds “Medical Marijuana: What We Think We Know”  (Larry) 5/15/19 Sanford Integrative Health Symposium: “Hypnosis and Hypnotic Language”  (Dan) 5/16/19 Sanford Integrative Health Symposium: “Medical Marijuana: What We Think We Know”

 (Larry) 9/17/19 Lecture to Physician Assistant Students; Sanford USD SOM: “Pediatric and Peri- natal Palliative Care”

Regional  (Dan) 7/12 Black Hills Peds Symposium: “You Are Primary Pediatric Palliative Care; Palliative Care Basics Every Clinician Should Know”

Volunteer Service Hospital/Clinic  (Dan) Biomedical Ethics Committee

Community  (Dan) leadership in Arise Church ministry team

Professional  (Larry) LifeScape Board of Directors

Other Awards  (Larry) Sanford Pioneer Award, 2019  (Larry) Sanford Star Quilt Award and Ceremony, 9/14/19

Pulmonary Dr. James Wallace, Division Chief Division Members Chuanpit Moser MD, Amit Jain MD, Deborah Hickman DNP

Teaching Medical Students Pillar 2 Morgan Sorensen Michael andreone Nate Whitsell Ahna Buntrock Victor Georgiev

Healthcare Profession Students SDSU Pharmacy Brooke Nibbelink Clinical Nurse Practitioner/Physician Assistant Students Tyler Hanson – NP Student Janea Paul – NP Student Shelby Retzer – PA Student Megan Klueber -- PA Student

Residents Ashley Coaston – PGY1 Shebeet Mangat – PGY1 Nathanial Nelson – PGY1 Anna Lisa Martino – PGY1 Jade Arrobas – PGY1 Molly Linn – PGY3

Scholarly Activity Grants Awarded CFF Center Award, CFF Therapeutic Development Center Grant

Clinical Service New Clinics/Programs/Outreach We are exploring outreach to Gillette, Wyoming

Volunteer Service Medical School  Dr Moser-Faculty Research and Education Committee for Sanford School of Medicine, Univer- sity of South Dakota  Deb Hickman- Pediatric CME Committee

Hospital/Clinic All of the below committees are Sanford Health Committees.  Dr. Moser is on the Pediatric Care Monitoring Committee.  Deb Hickman- Advanced Practice Provider Council Chair Sanford Health Sioux Falls Region  APP Onboarding & Mentoring Committee  APP Professional Development Committee  APP Professional Practice Committee

 Enterprise Clinical Practice Committee,  Enterprise Professional Health Committee  Physician Executive Council  Allied Health Credentials Committee  Dr. Wallace ended his tenure as Chair of the Physician Executive Council and now serves as Past Chair. He is a member of the Council of Governors, the PEC Executive Committee, the Clinical Practice Committee and the Pharmacy and Therapeutics Committee.

Professional Dr. Wallace  Continues to be a member of the Cystic Fibrosis Foundation’s Center Committee and serves as the representative for South Dakota for the Special Interest Group of the CFF for Newborn Screening for CF. Deb Hickman  National Association of Pediatric Nurse Practitioners July 2015- present Co-chair Asthma & Allergy Special Interest Group  Advanced Practice Nursing Advisory Committee February 2014- present South Dakota Board of Nursing

Other Current Clinical Research Trials  Corbus-A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis.  Vertex-VX16-809-120-A Post-approval Observational Study to Evaluate the Long-term Effective- ness and Safety of Orkambi in US Patients Who Completed Study VX12-809-105 Part A.  Vertex-VX17-659-105-A Phase 3, Open-label Study Evaluating the Long Term Safety and Effi- cacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation.  Vertex-VX15-661-113-A Phase 3, Open Label Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of VX-661 in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous or Heterozygous for the F508del CFTR Mutation.  Vertex VX18-445-113: A Phase 3, Open Label Study Evaluating the Long-Term Safety of VX- 445 Combination Therapy in Subjects with Cystic Fibrosis.  Savara SAV005-04-A Phase III, Randomized, Double-blind, Placebo-controlled Study of Aero- Vanc for the Treatment of Persistent Methicillin-resistant Staphylococcus Aureus Lung Infection in Cystic Fibrosis Patients.  A Prospective Observational Study in Cystic Fibrosis Patients With Chronic Respiratory Pseudo- monas Aeruginosa Infection Treated With TOBI® Podhaler™ (Tobramycin Inhalation Powder) or Other FDA Approved Inhaled Antipseudomonal Antibacterial Drugs. Seattle Children’s CF-FC-OB.

Recently Closed Studies  Vertex-VX17-659-102-A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF).  Vertex-VX17-659-103-A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del Mutation (F/F).  Vertex-VX16-659-101- A Phase 2, Randomized, Double-blind, Controlled Study to Evaluate the Safety and Efficacy of VX-659 Combination Therapy in Subjects Aged 18 Years and Older With Cystic Fibrosis  Vertex-VX17-661-116-A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Effi- cacy of Long-term Treatment With Tezacaftor in Combination With Ivacaftor in Subjects With Cystic Fibrosis Aged 6 Years and Older, Homozygous or Heterozygous for the F508del-CFTR Mutation.

Research Drs. Michelle Baack and Amy Elliott, Co-Division Chiefs Division Members Drs. Michelle Baack, Indra Chandrasekar, Randolph Faustino, Kevin Francis, Emily Griese, Kurt Griffin, Michael Kareta, Attila Kovacs, Lance Lee, Santiago Lopez, Samuel Milanovich, Thayne Munce, David Pearce, Kyle Roux, Alexei Savinov, Arielle Selya, Kameswaran Surendran, Jianning Tao, Jill Weimer

SANFORD

Teaching and Mentoring Sanford’s Research Division remains committed to training and mentoring the next generation of physicians and scientists through research training programs, didactic courses and seminars for every level of trainee within USD-SSOM. Individual faculty and their teaching and mentoring contributions are noted below in alphabetical order.

Michelle Baack Clinical Training Dr. Baack teaches medical students, residents and nurse practitioner students rotating through the Boekelheide NICU for clinical rotations. She also routinely participates in various Pediatric faculty and trainee conferences including the weekly Pediatric Resident NICU Morning Report. Mentoring Graduate Students  Megan Jorgensen; USD-SSOM MD/PhD training program, 2020-present. Mentor: Pilar De la Puente. Role: Thesis committee  Eli J Louwagie; USD-SSOM MD/PhD training program, 2018-present. Role: Mentor (2014-2018 undergraduate and MSI-II mentor; 2018-present pre-doctoral fellow).  Thesis: “Mitochondrial roles in developmentally programmed heart disease.”  Highlights: first-author publication in Pediatric Research, 3 co-authored papers in Am J Physiol Heart Circ Physiol, Nutrients, and International Journal of Molecular Sciences. Awards: Recipient of the Society for Pediatric Research (SPR) Student Research Award (2015). Travel Award and Co-Chaired Session APS Cardiovascular, Renal and Metabolic Diseases: Sex-Specific Implica- tions for Physiology Conference (2018). NIH-USDA Young Investigator Travel Award to As- pen/Snowmass Perinatal Biology Symposium (2019). Society for Pediatrics Research (SPR) MD-PhD Student Research Award (2020)  Ruthellen Anderson; USD-SSOM MD/PhD training program, 2017-present. Mentor: Kevin Fran- cis. Role: Thesis committee, Career advisor  Emily Storm; USD-SSOM MD/PhD training program, 2017-present. Mentor: Randy Faustino. Role: Thesis committee Residents  Emelia Stille, DO; USD-SSOM Pediatric Resident, 2020-present. Role: Research mentor Highlights: Midwest Society for Pediatric Research Poster Symposium: “Lactational Exposure to High-Fat Diet and Metformin Incites Myocardial Lipid Accumulation in Adult Male Offspring” Medical Students  Maya Gogoi; USD-SSOM Medical Student, 2020-present. Role: Co-mentor (Jacqueline Grev), Research mentor “Single center, retrospective, case-control study to determine attributable risks of corticosteroid use and adrenal insufficiency in very low birth weight (VLBW) infants.” High- lights: USD-SSOM, T32 CHIRP Grant Recipient  Claire Kittock, USD-SSOM MD/PhD training program, 2019. Role: Medical Student Research Program (MSRP) mentor (2019) Undergraduates  Michelle Carlson-Bennett, University of Dallas, Irving, TX; SPUR, 2019. Role: Mentor  Highlights: Multiple local presentations and co-authored paper in Reproductive Sciences entitled "Uteroplacental Insufficiency with Hypoxia Upregulates PlacentalPPARγ-KMT5A Axis in the Rat". Transitioned to pursue her PhD in Biological Sciences at Notre Dame University in 2020

 Andrew Paulson, Augustana University; SPUR/REU. Role: Mentor Highlights: Multiple local presentations. “Evaluation of huMSC isolation methods for use in cardiac regenerative medicine: explant vs. enzymatic digestion” and “Consequences of maternal diabetes on development of the myocardial mitochondrial reticulum” Courses/Lectures Neonatal Dermatology: Cause for Counsel or Concern? Pediatric Resident’s Noon Conference Se- ries

Indra Chandrasekar Mentoring Postdoctoral Fellows Dr. Karla Otterpohl, Postdoctoral fellow, 2015 – present. Role: Mentor Graduate Students  Mr. Brook Busselman, 2019 – present. Role: Mentor  Ms. Divya Kota, Graduate Program in Nanoscience and engineering, South Dakota School of Mines and Technology, 2017- 2020. Ms. Kota works on the Myosin II tension sensor project in my lab in collaboration with department of nanoscience and engineering at SDSMT. Role: Thesis committee  Mr. Ishara Ratnayake, Graduate Program in Nanoscience and engineering, South Dakota School of Mines and Technology, 2018 – 2019. I provide technical training and mentorship for Mr. Ratnayake’s work on TEM imaging of mouse kidneys. Role: Thesis committee  Ms. Rhiannon Sears, Sanford Research, USD BBS Graduate program, 2018 – present. Role: Thesis committee  Mr. Eric Fogarty, Sanford Research, 2017 – 2020. Role: Thesis committee Undergraduates  Mr. Mason Schmidt, SPUR/REU, 2019.  Highlights: Mason received the prestigious NSF BioREU travel award to present his summer research work in the lab at the American Society for Cell Biology Annual Meeting held in Washing- ton, D.C. Randy Faustino Mentoring Graduate Students  Megan Jorgensen, USD-SSOM MD/PhD training program, 2020-present. Role: Thesis committee  Emily Storm, USD-SSOM MD/PhD training program, 2017-present. Role: Mentor Undergraduates  Ashley Cain-Stoddard, BYU, Idaho (remote undergraduate intern), 2020. Role: Mentor  Ryan Burdine, Augustana University; SPUR/REU, 2018-2020. Role: Mentor Courses/Lectures  CPHD 601: Bioinformatics. Role: Lecturer  CPHD 763: Molecular Mechanisms of Disease, Cardiac Development and Genetic Regulation of Cardiac Development and Disease. Course Director: Lee, Role: Lecturer  Sanford Research Ethics Seminar Series, Plagiarism. Role: Lecturer

Kevin Francis Mentoring Postdoctoral Fellows and Graduate Students  Ruthellen Anderson, USD-SSOM MD/PhD training program, 2017-present. Role: Mentor  Highlights: NSF F30 Grant recipient for “Dynamic regulation of vesicular trafficking by altered sterol homeostasis.” Many platform presentations including MSPR, PAS, and SPR Student Re- search Award. Bethany Freel. USD BBS Ph.D. training program. Role: Mentor  Eric Sandhurst. USD Ph.D. training program, Neuroscience and Nanotechnology Network. Role: Mentor  Jordan Sheets, Ph.D., USD BBS; Postdoctoral fellow. Role: Mentor

 Sonali Sengupta, Ph.D., Bose Institute, Jadavpur University, India; Postdoctoral fellow. Role: Mentor  Eric Fogarty, USD BBS Ph.D. training program. Role: Dissertation committee  Johnny Sanyour, USD Biomedical Engineering Ph.D. training program. Role: Dissertation committee  Rachel Laufmann. USD BBS Ph.D. training program. Role: Dissertation committee  Kirby Rickel, USD Biomedical Engineering PhD. training program. Role: Dissertation committee  Rhiannon Sears, USD BBS Ph.D. training program. Role: Dissertation committee Undergraduates  Maycie Schultz – Augustana University, SD. Role: Mentor  Ben Kelvington – Augustana University, SD. Role: Mentor Courses/Lectures  CPHD 792: Molecular Mechanisms of Disease, Course Director: Lee, Role: Lecturer  CPHD 792: Cutting-Edge Techniques in Molecular Neuroscience, Role: Co-Director

Kurt Griffin Courses/Lectures  Genetics of Human Disease: Graduate Student Teaching—University of South Dakota. Lectures and discussion section on genetics of diabetes. Nov–Dec 2019  Pediatric Resident Lecture Series, USD-SSOM, September 3, 2020. The Sanford PLEDGE Study  Pediatric Grand Rounds, USD-SSOM, July 23, 2020. Type 1 Diabetes: Treatment, Interventions and Prevention.  Sanford Diabetes Care Conference, Sioux Falls, SD, August 23, 2019. T1D Research Update. Mentoring  Santiago Valdez, MD, 2019– Present

Michael Kareta Mentoring Postdoctoral Fellows and Graduate Students  Hannah Wollenzien, USD BBS Ph.D. training program. Role: Mentor  Anthony Restaino, USD MD/PhD training program, 2020-present. Mentor Paola Vermeer. Role: Dissertation committee  John Slunecka, USD MD/PhD training program, 2019-present. Mentor: Erik Ahli, PhD, Gareth Davies, PhD. Role: Dissertation committee  Emily Storm, USD MD/PhD training program, 2018-present. Mentor: Randy Faustino. Role: Dis- sertation committee  Eric Fogarty, USD BBS Ph.D. training program, 2018-2020. Mentor: Kamesh Surendran, PhD. Role: Dissertation committee Undergraduates  Lucas Simpson – Augustana University, SPUR/REU. Role: Mentor. Highlights: Transitioned to a PhD training program at the University of Rochester Courses/Lectures CPHD 601: Bioinformatics. Role: Lecturer

Lance Lee Leadership/Courses/Lectures  Course Director and Lecturer (8), CPHD725 Genetics of Human Disease  Course Director, CPHD602 Laboratory Rotations

Mentoring Postdoctoral Fellows Matthew Billion, postdoctoral fellow intern rotation. Graduate Students  Rachel Laufmann, USD BBS Masters Plan A. Role: Thesis committee

 Rama Patlola, USD BBS Masters Plan A. Role: Thesis committee  Haydee Torres, SDSU Biochemistry PhD training program. Role: Thesis committee Undergraduate Students Jennifer Kuiken, University of Sioux Falls, undergraduate research. Role: Mentor

Santiago Lopez Teaching Dr. Lopez is instrumental in clinical training of medical students and residents in clinical rotations in Pediatric Infectious Disease, as well as Vaccines and Prevention. Medical Students  Michael Wallum, MSIII  Landon Olson, MSIII  Austin Eggers, MSIV  Tyler Sternhagen, MSIV  Mona El-Gayes, MSIII  Megan Sommers, MSIV  Mathew Lommen, MSIII  Natalie Walter, MSIII Residents  Nathaniel Nelson, PGY-2  Rebecca Gehrmann, PGY-2  Caleb Hentges, PGY-2  Kristin Stuive PGY-2  Tara Robare, PGY-2  Joseph Presson, PGY-2 Mentoring Medical Students  Geralyn Palmer, MS, USD-SSOM, 2019-present  Travis Kooima, MS, USD-SSOM, 2019-present  Christopher VanHove, MS, USD-SSOM, 2019-present  Landon Withrow, MS, USD-SSOM, 2019-present Role: Project mentor Project: American Indian Children Outcomes During Lower Respiratory Tract Infection. Highlights: Poster presentation at IDWeek 2019, Washington DC; T. Denny Sanford Pediatric Fel- lowship Travel Award: Travis Kooima and Christopher Van Hove  Claire Porter, MS, USD-SSOM, 2019-present  Riley Paulsen, MD-PhD training program, USD-SSOM, 2019-present Project: American Indian Children Rates of Vaccination. Role: Primary mentor Courses/Lectures  USD-SSOM Department of Pediatrics Grand Rounds, Sioux Falls, SD. Native American Children and Lower Respiratory Tract Infection. Invited speaker.  Lectures: Fever of Unknown Origin  Neonatal Infection and Musculoskeletal Infection

Samuel Milanovich Dr. Milanovich is instrumental in clinical training of medical students and residents in clinical rotations in Pediatric Heme-Oncology. Teaching Medical students  Shauneil Schwartz, MS2 elective, 8/15/19  Parker Heger, pre-med under grad, 7/22/19, 7/29/19, 8/1/19  Elise Blaseg, MS2 elective, 7/25/19  Kelsey Westad, MS2 elective, 7/18/19

 Boggy Anton, MS3 continuity, 4/18-8/8/19  Mona El-Gayer, MS3 continuity, 9/5-10/3/19 Residents  Taryn Raschein, 7/1-7/26/19  Emelia Stille, 8/12-8/23/19  Joe Presson, 8/26-9/20/19  Caleb Hentges, 9/23-10/4/19 Undergraduates  Lucas Simpson, Augustana University, SPUR undergraduate research internship 9/2018-8/2019. Role: Mentor Mentoring  Baiba Steinbrekera, MD, Assistant Professor in Neonatology Division. Role: Career development mentor, USD-SSOM mentoring program  Dan Steventon, PT. Role: Research mentor. Highlights: DaCCoTA clinical partner award, for developing an assessment tool for neuropathy in young and developmentally delayed children un- dergoing cancer treatment. Courses/Lectures  South Dakota Academy of Physician Assistants, Fall CME Conference, Sioux Falls, SD. Ap- proach to hematology chief complaints in pediatric patients.  USD-SSOM Pediatric Grand Rounds, Sioux Falls, SD, January 29, 2019. Approach to hematology chief complaints in pediatric patients.  UND Pediatric Grand Rounds, Fargo, ND, November 26, 2019. Approach to hematology chief complaints in pediatric patients.

Thayne Munce Mentoring Graduate Students Kori Fink, USD Masters Student, Division of Kinesiology and Sport Management. Role: Mentor Undergraduate Students Kori Fink, University of Sioux Falls. Role: Research mentor Courses/Lectures Introduction to Exercise Science Course, University of Sioux Falls. Role: Lecturer

Kyle Roux Mentoring Graduate Students  Rhiannon Sears, USD BBS Ph.D. training program. Role: Mentor  Elle Anderson, USD MD/Ph.D training program. Role: Dissertation Committee  Emily Storm, USD MD/Ph.D training program. Role: Dissertation Committee  Eric Fogarty, USD Ph.D training program. Role: Dissertation Committee. Highlights: Defended with MS  Brook Busselman, USD Ph.D training program. Role: Dissertation Committee

Alexei Savinov Mentoring Graduate Students Rama Patlola, USD BBS, Master’s student. Courses/Lectures CPHD 792, Developmental Biology of Disease, USD BBS. Molecular Mechanisms of Disease – two part lecture. Role: Lecturer Arielle Selya Courses/Lectures CHPD 610: Logistic Regression Guest Lecture, USD BBS Department, 2020. Experimental Design and Analysis. Role: Lecturer

Kamesh Surendran Mentoring Postdoctoral Fellows  Malini Mukherjee Ph.D, (Staff Scientist). Role: Mentor/PI  Madhusudhana Janga Ph.D. (Staff Scientist). Role: Mentor/PI Graduate Students Eric Fogarty, USD Ph.D training program. Role: Graduate student advisor. Highlights: Defended with MS Undergraduate Students  Samantha Goetting, SPUR. Role: Mentor  Arianna Feller, Undergraduate Student, Sanford Health Internship Program (SHIP). Role: Mentor  Jasmine Johnson, High School Student, PROMISE Scholar. Role: Mentor Courses/lectures  CPHD 792, Genetics of Human Diseases. Role: Lecturer  CPHD 792, Developmental Biology of Disease. Role: Lecturer

Jill Weimer Mentoring Medical Students  Kayla Knutson, USD-SSOM Medical Student, MSRP Program, 2018-present. Role: Mentor Highlights: NIH-funded Children Health Research Program (CHIRP) recipient  Ryan Patrick, USD-SSOM Medical Student, 2018-present. Role: Mentor Highlights: NIH-funded Children Health Research Program (CHIRP) recipient  Jordan Dykstra, USD-SSOM Medical Student, Scholarships Pathways Program, 2018-present. Role: Mentor Postdoctoral fellows and Graduate Students  Brandon Meyerink, USD BBS Ph.D. training program. 2020-present. Role: Mentor  Matthew Stratton, Rosalind Franklin University of Medicine and Science, PhD training program, North Chicago, 2020-present. Role: Thesis committee  Lipsa Jenna, University of Arizona, PhD training program, Pharmacology, 2020-present. Role: Thesis committee  Anthony Restaino, USD-SSOM MD/PhD training program, 2020-present. Role: Committee member  Hannah Wollenzien, USD BBS Ph.D. training program, 2018-present. Role: Committee member  Bethany Freel, USD BBS Ph.D. training program, 2018-present. Role: Committee member  Rachel Laufmann, USD BBS Ph.D. training program, 2018-present. Role: Committee member  Ruthellen Anderson, USD MD/PhD training program, 2017-present. Role: Committee member: Undergraduate Students  McKayla Poppens, Augustana University, SPUR and Assistant Laboratory Technician, 2017- 2020. Current status: Medical Student, UCLA. Role: Mentor/PI  Lexis Sherron, Princeton University, SPUR 2016-2017; Summer Intern, 2018. Role: Mentor/PI Courses/Lectures  NSCI 792 U025 USD Neuroscience Journal Club (Course Director: Spring and Fall 2015, Spring 2016, Fall 2020)  CPHD 725. USD Genetics of Human Disease. 2019. Role: Lecturer

Scholarly Activity Sanford Research has been productive with scholarly work this academic year. Division publications, grants, presentations, and abstracts are highlighted for each faculty member in alphabetical order below.

Michelle Baack Publications  Preston CC, Larsen TD, Eclov JA, Louwagie EJ, Gandy TC, Faustino RS‡, Baack ML‡. Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways That Regulate Cardiac Metabo- lism and Cell Fate in Newborn Rat Hearts. Frontiers in Endocrinology. 2020 September; doi.org/10.3389/fendo.2020.570846. ‡Co-senior authorship.  Dominguez EC, Heires AJ, Pavlik J, Larsen TD, Guardado S, Sisson JH, Baack ML, Romberger DJ, Nordgren TM. A High Docosahexaenoic Acid Diet Alters the Lung Inflammatory Response to Acute Dust Exposure. Nutrients. 2020 Aug 4;12(8):2334. doi: 10.3390/nu12082334. PMID: 32759853; PMCID: PMC7468878  Brumbaugh JE, Bell EF, Grey SF, DeMauro SB, Vohr BR, Harmon HM, Bann CM, Rysavy MA, Logan JW, Colaizy TT, Peralta-Carcelen MA, McGowan EC, Duncan AF, Stoll BJ, Das A, Hintz SR. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia. J Pediatr. 2020 Apr;219:152-159.e5. doi: 10.1016/j.jpeds.2019.12.028. Epub 2020 Jan 31. PubMed PMID:32008764; PMCID:PMC7096270  Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore LA. Maternal Tobacco Smoke Exposure Causes Sex-Diver- gent Changes in Placental Lipid Metabolism in the Rat. Reprod Sci. 2020 Feb;27(2):631-643. doi: 10.1007/s43032-019-00065-w. Epub 2020 Jan 6. PubMed PMID:32046449.  Larsen TD, Sabey KH, Knutson AJ, Gandy TCT, Louwagie EJ, Lauterboeck L, Mdaki KS, Baack ML. Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in the De- veloping Fetal Rat Heart by Sex-Specific Mechanisms. Int J Mol Sci. 2019 Jun 25;20(12). doi: 10.3390/ijms20123090. PubMed PMID:31242551; PubMed Central PMCID:PMC6627740. Grants  NIH/NIGMS 2P20GM103620, Center of Biomedical Research Excellence (COBRE), Center for Pediatric Research. Pearce (PI). 9/01/18-8/31/23 Role: Project lead. Project title: Mitochondria, metabolic plasticity and cell fate in the developmental origin of fuel-mediated cardiomyopathy  NIH/NICHD Cooperative Multicenter Neonatal Research Network, 2UG1HD053109-11, Subaward: W000910508. Bell (PI). 01/01/17- present. Role: Sub-I Sanford Site PI for 15 Studies Presentations Oral  Multilineage Differentiation of MSCs. Stem Cell Affinity Club, Sanford Research, Sioux Falls, SD, February 20, 2020. Ty Gandy.  Aspen/Snowmass Perinatal Biology Symposium, Snowmass, CO, August 26th, 2019. Prenatal exposure to diabetes but not high-fat diet increases mitochondria-mediated cell death in adult rat cardiomyocytes. E Louwagie, T Larsen, K Mdaki, R Anderson, J Cain, M Baack. Travel award and platform presentation by Eli Louwagie, MD-PhD student.  Northern Great Plains Lipid Conference, Sioux Falls, SD. July 25, 2019. Placental Lipid Pro- cessing in DOHaD. Invited Speaker.  Northern Great Plains Lipid Conference, Sioux Falls, SD. July 26, 2019. Maternal high-fat diet increases the risk of heart disease in developing offspring. Platform presentation by Eli Louwagie, MD-PhD student  Stem Cell Affinity Club, Sanford Research, September 11, 2019. Mitochondrial transplantation in primary cardiomyocytes and mesenchymal stem cells. Eli Louwagie, MD-PhD student. Posters  NHLBI Mitochondrial Biology Symposium: On Mitochondrial Networks and Energetics. Bethesda, MD. September 27th, 2019. Mitochondrial transplantation improves respiratory capacity in neonatal cardiomyocytes exposed to maternal diabetes and high-fat diet. E. Louwagie*, M. Baack. *Poster Presentation.  Aspen/Snowmass Perinatal Biology Symposium, Snowmass, CO, August 26th, 2019. Wharton’s jelly and cord blood-derived 3D organized culture to measure biological development” by Tyler Gandy, Andrew Paulson, Pilar de la Puente, and Michelle Baack. Poster presentation by Ty Gandy.

 2019 NHLBI Mitochondrial Biology Symposium on Mitochondrial Networks and Energetics, Sep- tember 27, 2019. Transplantation Improves Respiratory Capacity in Neonatal Cardiomyocytes Exposed to Maternal Diabetes and High-Fat Diet. Eli J Louwagie, Tricia D Larsen, Michelle L Baack, MD. T. Denny Sanford Pediatric Fellowship Travel Award and poster presentation by Eli Louwagie, MD-PhD student.  Evaluation of hu-MSC isolation methods for use in cardiac regenerative medicine: explant vs. enzymatic digestion. Sanford Research Student Symposium. Andrew Paulsen, Ty Gandy, Michelle Baack. Poster by Andrew Paulsen, undergraduate student. Other Abstracts Abstracts selected for platform presentation, but scientific meeting was cancelled due to COVID-19.  Academic Society; Philadelphia, PA. May 2nd, 2020. Mitochondrial Transplantation Improves Cardiac Bioenergetics in Offspring of Diabetic Mothers Born with Cardiomyopathy. Eli Louwagie*, Tricia Larsen, Angela Wachal, Michelle Baack. *Platform Presentation. BBS Travel Award. SPR MD-PhD Student Research Award for best abstract.

Indra Chandrasekar Presentations Oral  Southern Salt Water and Kidney Club Meeting, Sarasota, FL. Role of actin associated molecular motor proteins Myh9 and Myh10 in TAL epithelial transport and tubular kidney disease. Decem- ber 4, 2019. Invited Speaker.  Emory University Renal Division Grand Rounds, Atlanta, GA. Loss of Myh9 and Myh10 molecular motor proteins in the adult mouse renal tubules results in progressive kidney disease. Janu- ary 2020. Invited Speaker.  Loyola University, Department of Cell and Molecular Physiology, Chicago, IL. Novel role(s) for Nonmuscle Myosin II isoforms in renal epithelial transport and kidney disease. March 2020. In- vited Speaker.  Sanford Research Seminar Series, Sioux Falls, SD. Novel role(s) for Nonmuscle Myosin II isoforms in renal epithelial transport and kidney disease. April 1st 2020. Invited Speaker. Posters  American Society for Cell Biology Annual Meeting, Washington D.C, Dec 2019. Conditional genetic inactivation of Nonmuscle Myosin II in adult mouse renal epithelium results in aberrant ER processing of GPI-anchored protein uromodulin. Karla L. Otterpohl, Ishara Ratnayake, Ryan G. Hart, Brook W. Busselman, Phil Ahrenkiel, Kameswaran Surendran and Indra Chandrasekar.  Bio REU travel award for Mason Schmidt, Washington DC. Characterization of Novel Immortal- ized Mouse Renal Proximal Tubular Epithelial Cells. Mason Schmidt, Karla Otterpohl, Brook Busselman, Indra Chandrasekar.

Randolph Faustino: Publications  Preston CC, Larsen TD, Louwagie EJ, Gandy TCT, Faustino RS‡, Baack ML‡. (2020): Maternal high-fat diet and diabetes disrupts transcriptomic pathways that regulate cardiac metabolism and cell fate in newborn rat hearts. Front Endocrinol. doi.org/10.3389/fendo.2020.570846. ‡Co-senior authorship.  Burdine RD, Preston CC, Leonard RJ, Bradley TA, Faustino RS. Nucleoporins in cardiovascular disease. J Mol Cell Cardiol. 2020 Apr;141:43-52. doi: 10.1016/j.yjmcc.2020.02.010. Epub 2020 Mar 21. PMID: 32209327; PMCID: PMC7394472  Leonard RJ, Preston CC, Gucwa ME, Afeworki Y, Selya AS, Faustino RS. Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot. Front Cardio- vasc Med. 2020 Feb 7;7:8. doi: 10.3389/fcvm.2020.00008. PMID: 32118046; PMCID: PMC7019101  Preston CC, Storm EC, Burdine RD, Bradley TA, Uttecht AD, Faustino RS. Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line. Sci Rep. 2019 Sep 3;9(1):12691. doi: 10.1038/s41598-019-49147-4. PMID: 31481660; PMCID: PMC6722237

Grants  Sanford Foundation. This pilot/feasibility grant was awarded to support the study of defining and optimizing minimum factors required for inducible hematopoiesis. Role: Co-I  Sanford Sport Science Institute (SSSI) and South Dakota State University (SDSU) Collaborative Grant. This pilot/feasibility grant was awarded to support work investigating circulating microRNA dynamics in collegiate level athletes before and after a structured training program. Faustino, van Guilder (PI). Role: Co-I Presentations Oral  Sanford Research Seminar Series, Sioux Falls, SD. June 2020. Finding new relationships for the heart: Networking for NUPS. Invited speaker.  Challenge Center Student Visit, Sanford Research, Sioux Falls, SD. January 2020. Cardiac Sci- ence Education. Invited speaker.  Augustana University CHEM130 Scientific Intersections and Impacts, Augustana University, Sioux Falls, SD. January 2020. Connecting with a Research Scientist. Invited speaker.  Concordia College Seminar, Moorhead, MN. January 2020. Systems Biology Approaches to Un- derstand Cardiovascular Development and Disease. Invited speaker. Posters  USD Ideafest, Vermillion, SD, 2020. Exploring Effects of Altered NUP153 Expression through CRISPR/dCas9 Systems. Ryan D. Burdine, Emily C. Storm, Tyler A. Bradley, Riley J. Leonard, Claudia C. Preston, Randolph S. Faustino.  AHA Basic Cardiovascular Sciences – Systems Approach to Cardiovascular Biology, Chicago, IL (virtual format due to COVID-19 pandemic). Potential functions of the nuclear basket in dilated cardiomyopathy. Claudia C. Preston, Ryan D. Burdine, Emily C. Storm, Randolph S. Faustino. Moderated Poster Session 3A.

Kevin Francis Publications  Sanyour HJ, Li N, Rickel AP, Torres HM, Anderson RH, Miles MR, Childs JD, Francis KR, Tao J, Hong Z. Statin-mediated cholesterol depletion exerts coordinated effects on the alterations in rat vascular smooth muscle cell biomechanics and migration. J Physiol. 2020 Apr;598(8):1505- 1522. doi: 10.1113/JP279528. Epub 2020 Mar 18. PMID: 32083311; PMCID: PMC7394245  Freel BA, Sheets JN, Francis KR. iPSC modeling of rare pediatric disorders. J Neurosci Meth- ods. 2020 Feb 15;332:108533. doi: 10.1016/j.jneumeth.2019.108533. Epub 2019 Dec 4. Erratum in: J Neurosci Methods. 2020 Jun 1;339:108739. PMID: 31811832; PMCID: PMC7310918 Grants  NIH/NIGMS 2P20GM103620, Center of Biomedical Research Excellence (COBRE), Center for Pediatric Research. Pearce (PI). 9/01/18-8/31/23 Role: Project lead. Project title: Regulation of cell fate and function by sterol homeostasis  The Giving Back Fund. Small molecule screening for CLN6-Batten disease. Francis (PI) 12/23/19 – 12/22/20. Role: PI  NIH/NINDS 1F30NS106788-01. Dynamic regulation of vesicular trafficking by altered sterol homeostasis. 2/20/18 – 2/19/22. Anderson (PI), Francis (Mentor).  USD Neuroscience, Nanotechnology, and Networks (USD-N3) Fellowship. Characterizing astro- cyte pathology and resulting phenotypes in cholesterol synthesis disorders. 08/22/19 – 08/21/20. Freel (PI), Francis (Mentor).  NIH/NINDS 1 R01 NS113233-01A1. Reading Frame Correction for the Treatment of CLN3-Bat- ten Disease. Hastings (PI), Francis (Co-I).

Presentations Oral  South Dakota State University, Department of Pharmaceutical Sciences, Brookings, SD, Febru- ary 19th, 2020. Lipid metabolism at the intersection of biological chemistry and human health. Invited speaker.

 USD Center for Brain and Behavior Research Annual Symposia, Vermillion, SD, August 16th, 2019. The role of sterol homeostasis in mediating membrane curvature: implications for trafficking deficits within cholesterol synthesis disorders. Invited speaker.  USD Center for Brain and Behavior Research Annual Symposia, Vermillion, SD, August 16th, 2019. Multifunctional biodegradable porous microspheres to act as a delivery platform and three- dimensional model for neurological disease. Invited speaker.  MD PhD National Student Conference, Denver, CO, September 27th, 2020. Cholesterol and sterol intermediates lower energetic barriers for membrane bending and fission necessary for ef- ficient clathrin mediated endocytosis. Authors: Ruthellen Anderson, Kem Sochacki, Harika Vup- pula, Brandon Scott, Elizabeth Bailey, Maycie Schultz, Jason Kerkvliet, Justin Taraska, Adam Hoppe, Kevin Francis.  Training in Neurotherapeutics Discovery and Development for Academic Scientists, Bethesda, MD, March 5th, 2020. Small molecule screen for normalization of neuronal cellular deficits using human iPSC-derived models. Author: Kevin Francis.  Society for Neuroscience Annual Meeting, Chicago, IL, October 19th, 2019. Cln6 deficient glia are primed for activation and contribute to the neuronal deficits observed in CLN6 Batten disease. Invited speaker. Authors: Jordan Sheets, Bethany Freel, Jake Cain, Jill Weimer, Kevin Francis. Posters  USD Center for Brain and Behavior Research Annual Symposia, Vermillion, SD, August 16th, 2019. Freel B et al. Genetic disruption of cholesterol biosynthesis inhibits astrogenesis and induces neurodevelopmental deficits through perturbation of Wnt signaling. Authors: Bethany Freel, Nicholas Coungeris, Ben Kelvington, Kevin Francis.  Society for Neuroscience Annual meeting, Chicago, IL October 19th, 2019. Genetic disruption of cholesterol biosynthesis inhibits astrogenesis and induces neurodevelopmental deficits through perturbation of Wnt signaling. Authors: Bethany Freel, Nicholas Coungeris, Ben Kelvington, Kevin Francis.  Society for Neuroscience Annual meeting, Chicago, IL, October 19th, 2019. Multifunctional biodegradable porous microspheres act as a delivery platform and three-dimensional model for neurological disease. Authors: Eric Sandhurst, Sharad Jaswandkar, Dinesh Katti, Kalpana Katti, Hongli Sun, Dan Engebretson, Kevin Francis.  Kern Lipid Conference, Vail, CO, July 2019. Defining the developmental and functional consequences of genetic disruption of cholesterol biosynthesis using human stem cell models. Au- thors: Nicholas Coungeris, Bethany Freel, Jordan Sheets, Jing Zhao, Kevin Francis.

Kurt Griffin Grants  Helmsley Charitable Trust. Sanford PLEDGE. 2020-2022. [Sanford Project Leveraging Differen- tial Gene Expression against Type 1 Diabetes]. Role: PI  NIH/SBIR: 1 R44 AI142905-03, 9/2020-8/2021. Savinov (PI). Advancing a Candidate Human Polyclonal Anti-Thymocyte Globulin Product Produced in Transchromosomal Bovine for Trans- plant Induction/Acute Rejection and T1D Therapy. Role: Co-investigator. Presentations  Genetics of Human Disease: Graduate Student Teaching—University of South Dakota. Lectures and discussion section on genetics of diabetes. Nov–Dec 2019  Pediatric Resident Lecture Series, USD-SSOM, September 3, 2020. The Sanford PLEDGE Study  Pediatric Grand Rounds, USD-SSOM, July 23, 2020. Type 1 Diabetes: Treatment, Interventions and Prevention.  Sanford Diabetes Care Conference, Sioux Falls, SD, August 23, 2019. T1D Research Update.

Michael Kareta Publications  Hoxha S, Shepard A, Troutman S, Diao H, Doherty JR, Janiszewska M, Witwicki RM, Pipkin ME, Ja WW, Kareta MS, Kissil JL. YAP-Mediated Recruitment of YY1 and EZH2 Represses Tran- scription of Key Cell-Cycle Regulators. Cancer Res. 2020 Jun 15;80(12):2512-2522. doi: 10.1158/0008-5472.CAN-19-2415. Epub 2020 May 14. PMID: 32409309; PMCID: PMC7299785.  Lee QY, Mall M, Chanda S, Zhou B, Sharma KS, Schaukowitch K, Adrian-Segarra JM, Grieder SD, Kareta MS, Wapinski OL, Ang CE, Li R, Südhof TC, Chang HY, Wernig M. Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Nat Cell Biol. 2020 Apr;22(4):401- 411. doi: 10.1038/s41556-020-0490-3. Epub 2020 Mar 30. PMID: 32231311. Grants  Sanford Health Foundation Cellular Therapies & Stem Cell Biology Pilot and Feasibility Grant. Induced Hematapoietic Cell Reprogramming in Pathologic and Non-pathologic Conditions. Role: Co-I Presentations Oral  SDSU Invited Scientific Seminar. Invited speaker.  UNMC Invited Scientific Seminar. Invited speaker. Posters  2 posters presented at the AACR/IASLC Lung Cancer Meeting

Attila Kovacs Publications  Johnson TB, Langin LM, Zhao J, Weimer JM, Pearce DA, Kovács AD. Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water. Sci Rep. 2019 Oct 18;9(1):14962. doi: 10.1038/s41598-019- 51488-z. PMID: 31628420; PMCID: PMC6802212  Parker C, Zhao J, Pearce DA, Kovács AD. Comparative analysis of the gut microbiota composition in the Cln1R151X and Cln2R207X mouse models of Batten disease and in three wild-type mouse strains. Arch Microbiol. 2020 Aug 4. doi: 10.1007/s00203-020-02007-6. PMID: 32749661 Grants  Revance Therapeutics, Inc., Revance Compound Evaluations. Chan (PI); Role: Research Scien- tist Posters  Center for Pediatric Research Symposium, Sioux Falls, SD, October 29, 2019. Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water. Attila D. Kovács, Tyler B. Johnson, Logan M. Langin, Jing Zhao, Jill M. Weimer and David A. Pearce.

Lance Lee Publications  McKenzie CW, Lee L. Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia. Sci Rep. 2020 Jul 23;10(1):12337. doi: 10.1038/s41598-020-69359-3. PMID: 32704025; PMCID: PMC7378221  Lee L, Ostrowski LE. Motile cilia genetics and cell biology: big results from little mice. Cell Mol Life Sci. 2020 Sep 11. doi: 10.1007/s00018-020-03633-5. Epub ahead of print. PMID: 32915243. Grants  Dakota Seeds (State of South Dakota); Undergraduate research support; PI: Lee; 2020  NSF REU; “REU Site in Cellular and Molecular Biology at Sanford Research” (# 1756912); PI: Lee; 2019-2022  NIH R25; “Pediatric Biomedical Research Program” (# R25HD097633); PDs: Lance Lee, Jill Weimer; 2019-2024

Presentations Oral  Dordt University, Sioux Center, IA. The Biology of Cilia in Pediatric Disease. 2019. Invited seminar speaker.  United Tribes Technical College, Bismarck, ND. The Biology of Cilia in Pediatric Disease. 2020. Invited seminar speaker. Posters  6th Annual Center for Pediatric Research Symposium. October 2019. Sioux Falls, SD. Analyz- ing Protein Trafficking in Live Mouse Cilia. Jennifer Kuiken, Casey McKenzie, Indra Chandra- sekar, and Lance Lee.

Santiago Lopez Publications  Lopez SMC, Martin JM, Johnson M, Kurs-Lasky M, Horne WT, Marshall CW, Cooper VS, Wil- liams JV, Shaikh N. A method of processing nasopharyngeal swabs to enable multiple testing. Pediatr Res. 2019 Nov;86(5):651-654. doi: 10.1038/s41390-019-0498-1. Epub 2019 Jul 9. PMID: 31288247; PMCID: PMC6851467  Enzmann MO, Erickson MP, Grindeland CJ, Lopez SMC, Hoover SE, Leedahl DD. Treatment and preliminary outcomes of 150 acute care patients with COVID-19 in a rural health system in the Dakotas. Epidemiol Infect. 2020 Jun 22;148:e124. doi: 10.1017/S0950268820001351. PMID: 32605683; PMCID: PMC7330277  Lopez SMC, Davis A, Zinn M, Feingold B, Green M, Michaels MG. Bartonella henselae infection in the pediatric solid organ transplant recipient. Pediatr Transplant. 2020 Aug 25:e13823. doi: 10.1111/petr.13823. Epub ahead of print. PMID: 32841466 Presentations Oral  COVID-19 Immune Response. Invited speaker.  Argentinean Pediatric Infectious Disease Society. Invited speaker.

Samuel Milanovich Publications  Frost FG, Cherukuri PF, Milanovich S, Boerkoel CF. Pan-cancer RNA-seq data stratifies tumours by some hallmarks of cancer. J Cell Mol Med. 2020 Jan;24(1):418-430. doi: 10.1111/jcmm.14746. Epub 2019 Nov 15. PMID: 31730267; PMCID: PMC6933344. Grants  Alex’s Lemonade Stand Foundation / Northwestern Mutual Childhood Cancer Impact Award. Mi- lanovich (PI). Characterizing transcriptional regulation in hematopoiesis and acute leukemia. 7/1/19-12/31/20. Role: PI.

Thayne Munce Publications  Bond CW, Dorman JD, MacFadden LN, Munce TA. Dynamic postural stability in active, adolescent males following repeated bouts of aerobic exercise in hot and temperate environments: a pilot study. Mil Med. 2020;185(Suppl 1):368-375. https://pubmed.ncbi.nlm.nih.gov/32074301/ Grants  NIH/IDeA: Great Plains IDeA-CTR Pilot Grant Program. Injury Rates and Physical Activity in Youth Football: Tackle vs. Flag. Role: Project PI Presentations  See Abstracts as presentations were cancelled with conferences due to COVID-19.

Abstracts  Dorman JC, Fink KJ, Poel DN, Munce TA. Determinants of head impact exposure in youth football. Dorman, Jason C., Fink, Kori J., Poel, Daniel N A., Munce Thayne. Less Med Sci Sports Exerc. 2020;52(7S):66-67.  Munce TA, Poel DN. Assessment of neurologic function in mixed martial arts fighters following a single competition. Med Sci Sports Exerc. 2020;52(7S):619.  Poel DN, Munce TA. Assessment of neurological function in mixed martial arts fighters following a single training session. Med Sci Sports Exerc. 2020;52(7S):620.

David Pearce Publications  Horowitz M, Simkins J, Pearce DA. The Sanford Lorraine Cross Award for medical innovation: Advancing a rigorous and repeatable method for recognizing translational research leaders who today are bringing emerging transformative innovations to patients. J Clin Transl Res. 2020 Jan 28;5(2):80-90. PMID: 32377583; PMCID: PMC7197048  Parker C, Zhao J, Pearce DA, Kovács AD. Comparative analysis of the gut microbiota composition in the Cln1R151X and Cln2R207X mouse models of Batten disease and in three wild-type mouse strains. Arch Microbiol. 2020 Aug 4. doi: 10.1007/s00203-020-02007-6. Epub ahead of print. PMID: 32749661  Langin L, Johnson TB, Kovács AD, Pearce DA, Weimer JM. A tailored Cln3Q352X mouse model for testing therapeutic interventions in CLN3 Batten disease. Sci Rep. 2020 Jun 29;10(1):10591. doi: 10.1038/s41598-020-67478-5. PMID: 32601357; PMCID: PMC7324379  Johnson TB, Langin LM, Zhao J, Weimer JM, Pearce DA, Kovács AD. Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water. Sci Rep. 2019 Oct 18;9(1):14962. doi: 10.1038/s41598-019- 51488-z. PMID: 31628420; PMCID: PMC6802212 Grants  NIH/NIGMS 2P20GM103620, Center of Biomedical Research Excellence (COBRE), Center for Pediatric Research. Pearce (PI). 9/01/18-8/31/23 Role: PI Presentations  Forum Research, virtual event, July 2020. Conducting Clinical Trials Amid COVID-19 Working Group.  Alliance for Cell Therapy Now (ACT-NOW), virtual event, September 2020. Roundtable Partici- pant “Exploring Public Policy: Regenerative Medicine and Cell Therapies” Advanced Therapies Congress & Expo 2020, London, April 2020. Session Chair “Innovation Track”  Rare Diseases and Orphan Drugs Congress, Buenos Aires, March 2020. “The International Rare Diseases Research Consortium (IRDiRC): Reaching out to Policy Markers on Rare Diseases” and “Team Science: Integrating Natural Histories into EHRs for more Accurate Diagnosis”  RE(ACT) Congress and IRDiRC Conference 2020, Berlin, March 2020. Session Chair “Method- ologies to Assess the Effect of Diagnosis and Therapies on RD Patients”  Alliance for Cell Therapy Now (ACT-NOW)/Bipartisan Policy Center Roundtable on Regenerative Cell Therapies, Washington D.C., January 2020. Roundtable Participant “Regenerative Medi- cine: Real-World Evidence to Measure Outcomes and Support Regulatory, Payment and Other Decision-Making”  World Stem Cell Summit, Miami, January 2020. Session Chair “Update from the Innovators – Neurology and Aging Diseases”  14th Meeting of the International Conference on Rare Diseases and Orphan Drugs (ICORD), Tel Aviv, November 2019. Panelist “Health Policy Makers from the World”  2019 HEALinc Future Health Innovation Summit, Bahamas, October 2019. Expert Think-Tank Panelist “Methodology and Real-World Study Design” and Case Studies Panelist “Case-Studies and Global Action Steps”  Rare Diseases Forum 1, Washington DC, September 2019. Panelist “Innovation in Trial Designs: Braking Lessons from the Oncology Experience to Rare Diseases”

 Congressional Briefing on Regenerative Cell Therapies: Making Safe and Effective Treatments Available to Patients, Washington DC, September 2019. Meeting Participant.  Rare Disease Research Symposium, New York, September 2019. Keynote “Coordination of In- ternational Research on Rare Diseases”

Kyle Roux Publications  Sears RM, Roux KJ. Diverse cellular functions of barrier-to-autointegration factor and its roles in disease. J Cell Sci. 2020 Aug 17;133(16):jcs246546. doi: 10.1242/jcs.246546. PMID: 32817163; PMCID: PMC7449794.  May DG, Scott KL, Campos AR, Roux KJ. Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation. Cells. 2020 Apr 25;9(5):1070. doi: 10.3390/cells9051070. PMID: 32344865; PMCID: PMC7290721  Hussain S, Bedekovics T, Ali A, Zaid O, May DG, Roux KJ, Galardy PJ. A cysteine near the C- terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphor- ylation, eIF4F assembly, and malignant B-cell survival. Cell Death Discov. 2019 Dec 10;5:152. doi: 10.1038/s41420-019-0231-1. PMID: 31839994; PMCID: PMC6904616  Zhang Q, Narayanan V, Mui KL, O'Bryan CS, Anderson RH, Kc B, Cabe JI, Denis KB, Antoku S, Roux KJ, Dickinson RB, Angelini TE, Gundersen GG, Conway DE, Lele TP. Mechanical Stabili- zation of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. Curr Biol. 2019 Sep 9;29(17):2826-2839.e4. doi: 10.1016/j.cub.2019.07.021. Epub 2019 Aug 8. PMID: 31402305; PMCID: PMC6736724  Halfmann CT, Sears RM, Katiyar A, Busselman BW, Aman LK, Zhang Q, O'Bryan CS, Angelini TE, Lele TP, Roux KJ. Repair of nuclear ruptures requires barrier-to-autointegration factor. J Cell Biol. 2019 Jul 1;218(7):2136-2149. doi: 10.1083/jcb.201901116. Epub 2019 May 30. PMID: 31147383; PMCID: PMC6605789 Grants  NIH/NIGMS R35GM126949-01. Roux (PI). 09/01/2018 - 06/30/2023. Evolution and application of proximity protein labeling. Role:PI  NIH/NIGMS 6P20GM103620-06. Center for Pediatric Research. Pearce (PI). 09/01/2018 - 08/31/2023. Role: Program Coordinator  NIH/NIGMS P20GM103620. Center for Pediatric Research, The Biochemistry Core. Pearce (PI); 09/01/2018-08/31/2023. Role: Co-Core Lead 5P20GM103620-05 (Pearce)  NIH/NIBIB R01EB014869-02 Lele (PI). 08/01/2012 – 06/30/2020. Substrate Rigidity and Gene Expression: Role of Nuclear Tension. Role: Co-I

Presentations Oral  Augustana University, Sioux Falls, SD. February 19, 2020. Tracking Protein Footprints with Bi- oID. Invited Speaker. Abstracts  American Society of Cell Biology Annual Meeting, Washington DC. 2019. Nuclear rupture as a potential shared mechanism of nuclear envelope-associated progeria. Sears R. Roux KJ.  American Society of Cell Biology Annual Meeting, Washington DC. 2019. Distinguishing the practical applications of BioID and TurboID. May DG, Scott K, Roux KJ.  American Society of Cell Biology Annual Meeting, Washington DC. Barrier to autointegration factor: A well-regulated mechanisms to repair nuclear ruptures. Halfmann C, Sears R, Katiyar A, Busselman BW, Aman L, Zhang Q, Lele TP, Roux KJ.

Alexei Savinov Publications  Liu C, Whitener RL, Lin A, Xu Y, Chen J, Savinov A, Leiding JW, Wallet MA, Mathews CE. Neu- trophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes. Front Immunol. 2019 May 1;10:952. doi: 10.3389/fimmu.2019.00952. PMID: 31118934; PMCID: PMC6504685

 Radichev IA, Yoo J, Scott DW, Griffin K, and Savinov AY. Towards Antigen-specific Tregs for Type 1 Diabetes: Construction and Functional Assessment of Pancreatic Endocrine Marker, HPi2-based Chimeric Antigen Receptor. Cellular Immunology, In Press, Available online 30 Sep- tember 2020. Grants  NEXTCURE 20192115. Savinov (PI), 09/25/2019 – 07/24/2021. Selected Aspects of Human B7- H4 (VTCN1) Immunobiology. Role: PI Presentations Oral  Department of Microbiology and Immunology, Laval University, Quebec City, Canada, June 2019. Chimeric T regulatory Cells for type diabetes treatment. (Presented virtually due to COVID-19 pandemic) Poster  2020 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium. Development and in vitro characterization of fully human anti-thymoglobulin for T1D treatment. Rama Patlola, Ilian Radichev, Hua Wu, Christoph Bausch, Tom Luke, Kurt Griffin, Eddie Sullivan, and Alexei Savinov.

Arielle Selya Publications  Deutsch AR, Selya AS. Dynamic change in the association of a cigarettes-per-day polygenic risk score across the numeric range of its corresponding phenotype over adolescence and young adulthood. Addict Behav. 2020 Jul 23;112:106571. doi: 10.1016/j.addbeh.2020.106571. Epub ahead of print. PMID: 32763622  Deutsch AR, Selya AS. Stability in effects of different smoking-related polygenic risk scores over age and smoking phenotypes. Drug Alcohol Depend. 2020 Sep 1;214:108154. doi: 10.1016/j.drugalcdep.2020.108154. Epub 2020 Jul 2. PMID: 32645681; PMCID: PMC7423706  Bainter T, Selya AS, Oancea SC. A key indicator of nicotine dependence is associated with greater depression symptoms, after accounting for smoking behavior. PLoS One. 2020 May 22;15(5):e0233656. doi: 10.1371/journal.pone.0233656. PMID: 32442211; PMCID: PMC7244154  Foxon F, Selya AS. Electronic cigarettes, nicotine use trends and use initiation ages among US adolescents from 1999 to 2018. Addiction. 2020 Apr 25. doi: 10.1111/add.15099. Epub ahead of print. PMID: 32335976  Leonard RJ, Preston CC, Gucwa ME, Afeworki Y, Selya AS, Faustino RS. Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot. Front Cardio- vasc Med. 2020 Feb 7;7:8. doi: 10.3389/fcvm.2020.00008. PMID: 32118046; PMCID: PMC7019101  Kim S, Selya AS. The Relationship Between Electronic Cigarette Use and Conventional Ciga- rette Smoking Is Largely Attributable to Shared Risk Factors. Nicotine Tob Res. 2020 Jun 12;22(7):1123-1130. doi: 10.1093/ntr/ntz157. PMID: 31680169; PMCID: PMC7291806  Selya AS, Ivanov O, Bachman A, Wheat D. Youth smoking and anti-smoking policies in North Dakota: a system dynamics simulation study. Subst Abuse Treat Prev Policy. 2019 Aug 20;14(1):34. doi: 10.1186/s13011-019-0219-0. PMID: 31429769; PMCID: PMC6701071  Selya A, Johnson EL, Weber TL, Russo J, Stansbury C, Anshutz D, Griese E, Hsu B. Smoking is associated with a higher risk of unplanned medical visits among adult patients with diabetes, using retrospective electronic medical record data from 2014 to 2016. BMC Health Serv Res. 2020 May 6;20(1):383. doi: 10.1186/s12913-020-05277-4. PMID: 32375742; PMCID: PMC7204008  Doerrmann C, Oancea SC, Selya A. The Association Between Hours Spent at Work and Obesity Status: Results From NHANES 2015 to 2016. Am J Health Promot. 2020 May;34(4):359-365. doi: 10.1177/0890117119897189. Epub 2020 Jan 3. PMID: 31898469; PMCID: PMC7166176

Grants  NIH/GMS Center for Health Outcomes and Population Research CoBRE. Role: Project Lead, Director of The Data Exchange Core Presentations Oral  SDSU Data Science Symposium, Brookings, SD, 2/11/2020. Opportunities for improving health through big data & data science. Invited speaker  USD-BBS Seminar Series, Vermillion, SD, 12/7/2019. Sanford Data Exchange: On-demand access to electronic medical record data for researchers. Invited speaker  Society for Nicotine & Tobacco Research, New Orleans, LA, March 2020. Using simulation modeling to examine gateway vs diversion accounts of electronic cigarettes. Selya, A., Foxon, F., & Bachman, A.  System Dynamics Society, July 2020. Trends in Electronic Cigarette Use and Conventional Smoking: Quantifying a Possible ‘Diversion’ Effect among U.S. Adolescents. Selya, A. Presented virtually. Poster  Society for Nicotine & Tobacco Research, New Orleans, LA, March 2020. Electronic cigarettes as a method of harm reduction at the population level. Foxon, F. & Selya, A.

Kamesh Surendran Publications  Mukherjee M, DeRiso J, Janga M, Fogarty E, Surendran K. Foxi1 inactivation rescues loss of principal cell fate selection in Hes1-deficient kidneys but does not ensure maintenance of principal cell gene expression. Developmental Biology. 2020 Oct 1;466(1-2):1-11. PubMed PMID: 32800756; PubMed Central PMCID: PMC7494575  Mukherjee M, Ratnayake I, Janga M, Fogarty E, Scheidt S, Grassmeyer J, deRiso J, Chandra- sekar I, Ahrenkiel P, Kopan R, Surendran K. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. FASEB J. 2020 Jul;34(7):9512-9530. PubMed PMID: 32474964; PubMed Central PMCID: PMC7501208  Mukherjee M, Fogarty E, Janga M, Surendran K. Notch Signaling in Kidney Development, Maintenance, and Disease. Biomolecules. 2019 Nov 4;9(11). Review. PubMed PMID: 31690016; PubMed Central PMCID: PMC6920979 Grants  Sanford Health Foundation Pilot Grant. Development of individualized therapies for Alagille Syn- drome. Surendran (PI); 05/01/2019-08/30/2020. Role: PI  NIH/NIDDK- R01 DK106135. Molecular Regulators of Renal Collecting Duct Differentiation and Maintenance. Surendran (PI); 07/01/2016-05/31/2021. Role: PI  NIH/NIGMS P20GM103620. Center for Pediatric Research Functional Genomics and Bioinfor- matics Core. Pearce (PI); 09/01/2018-08/31/2023. Role: Co-Core Lead Presentations Oral  American Society of Nephrology Kidney Week, Washington D.C., November 9th, 2019. Session: Cell Fate Choices in Kidney Development. Differentiation of Distinct Cell Types Within the Col- lecting Duct Epithelium. Invited speaker.  8th International Symposium and Scientific Meeting on Alagille Syndrome, Cincinnati, OH, June 2019. Clues from mouse kidney disease studies as to the disease variability in ALGS. Invited speaker.  NIH/NIGMS IDeA Central Region Conference, Oklahoma City, OK, June 2019. The involvement of Notch mediated lateral inhibition in kidney collecting duct cell type differentiation and maintenance. Invited speaker.

Jianning Tao Publications  VanCleave A, Palmer M, Fang F, Torres H, Rodezno T, Li Q, Fuglsby K, Evans C, Afeworki Y, Ross A, Rao P, Leiferman P, Zheng S, Houghton P, Tao J. Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway. Oncotarget. 2020 Jul 7;11(27):2597-2610. doi: 10.18632/oncotarget.27611. PMID: 32676162; PMCID: PMC7343631  Sanyour HJ, Li N, Rickel AP, Torres HM, Anderson RH, Miles MR, Childs JD, Francis KR, Tao J, Hong Z. Statin-mediated cholesterol depletion exerts coordinated effects on the alterations in rat vascular smooth muscle cell biomechanics and migration. J Physiol. 2020 Apr;598(8):1505- 1522. doi: 10.1113/JP279528. Epub 2020 Mar 18. PMID: 32083311; PMCID: PMC7394245 Grants  NIH/NIGMS P20GM103620. Center for Pediatric Research. Pearce (PI); 09/01/2018- 08/31/2023. Role: Project Lead. Project Title: Dissecting of developmental signaling pathways in bone development and osteosarcoma  National Science Foundation (NSF) 1725656. MRI: Acquisition of a Micro-CT system for 3D tissue and materials structure analysis. Engebretson (PI); 11/01/2017-10/31/2020. Role: Co-PI  2020 T. Denny Sanford Pediatric Collaborative Research Award. Characterization of Pediatric Lateral Meningocele Syndrome Mouse Model and Treatment. Tao/Westendorf (PI). 01/01/2020 – 12/31/2020. Role: Co-I Presentations Oral  Sanford Research ethics seminar series, Sioux Falls, SD, July 29, 2020. Ethics: Peer review. Role: Co-presenter with Pilar De La Peunte  Sanford Research Series Seminar, Sioux Falls, SD, March 25, 2020. Skeletal Notch and p53: From congenital disease to genome-guided therapeutic vulnerabilities in osteosarcoma. Role: Invited speaker Poster  2019 Sanford Undergraduate Summer Research Symposium, Sioux Falls, SD, August 9, 2019. The effects of a pan-HDAC inhibitor, SAHA, on a novel murine osteosarcoma cell line. Callahan, D., Torres, H., VanCleave, A., Tao, J.  2019 Sanford Undergraduate Summer Research Symposium, August 9, 2019, Sioux Falls, SD. The Role of Notch3 in Human Osteosarcoma Cells. Conn, J., Restaino, A., Torres, H., Van- Cleave, A., Tao, J.  2019 Sanford Undergraduate Summer Research Symposium, August 9, 2019, Sioux Falls, SD. Dual Targeting Notch-Regulated Histone Deacetylase and Demethylase in a Cellular Model of Human Osteosarcoma. Smithback A, Palmer M., Torres, H., VanCleave, Tao, J.  The South Dakota EPSCoR Undergraduate Symposium, July 30, 2019, Sioux Falls, SD. The effects of a pan-HDAC inhibitor, SAHA, on a novel murine osteosarcoma cell line. Callahan, D., Torres, H., VanCleave, A., Tao, J.  The 3rd Annual Eastern South Dakota Research Symposium, June 12, 2019, Sioux Falls, SD. Identification of Novel Notch1 Interacting Partners in Osteosarcoma Cells. Torres, H., Fang, F., Danielle, M., Roux, K., and Tao, J.  The 3rd Annual Eastern South Dakota Research Symposium, June 12, 2019, Sioux Falls, SD. Unlocking Molecular Signatures of Osteosarcoma Subtypes using Trp53 mutated mouse models. Fang, F., Torres, H., VanCleave, A., Janga, M., Rickel, K., Evans C., Zhao, J., Zhang, E., and Tao, J.  USD-SSOM 2019 Medical Student Research Forum Conference, July 19, 2019, Vermillion, SD Production of Stable Osteosarcoma Cell Lines with NOTCH3 shRNA Knockdown. Restaino, A., Torres, H., Conn, J., VanCleave, A., Fang, F., Tao, J.  USD-SSOM 2019 Medical Student Research Forum Conference, July 19, 2019, Vermillion, SD. Dual Targeting Notch-Regulated Histone Deacetylase and Demethylase in a Cellular Model of Human Osteosarcoma. Palmer, M., Tao, J.

 American Society for Bone and Mineral Research (ASBMR) Virtual Annual Meeting poster presentation, September 11-15, 2020. Characterization of a Pediatric Lateral Meningocele Syn- drome Mouse Model. Torres, H., VanCleave, A., Rodezno T., MukherjeeM., Westendorf J., and Tao, J  2020 American Association for Cancer Research (AACR), (abstract accepted for presentation on April 27 - 28, 2020, San Diego, CA but was moved to a virtual meeting, June 22-24, 2020. An- titumor effects of an epigenetic inhibitor, 4SC-202, on human osteosarcoma cells. Torres, H., VanCleave, Palmer, Callahan D, Smithback A, May D, Fang F, Roux K, and Tao, J.  2020 American Association for Cancer Research (AACR), (abstract accepted for presentation on April 27 - 28, 2020, San Diego, CA but was moved to a virtual meeting, June 22-24, 2020. Defin- ing the properties of the OS-33 osteosarcoma cell line and the effects of mTORC1 inhibition by rapamycin treatment. VanCleave, Palmer, M., Fang, F., Torres, H., Alan R., Leiferman P., Houghton P. and Tao, J.  American Society for Bone and Mineral Research (ASBMR) Annual Meeting, 2019 September 20-23, Orlando, FL (2019 ASBMR Diversity Poster Competition). Unlocking Molecular Signa- tures of Osteosarcoma Subtypes using Trp53 mutated mouse models. Torres, H., Fang, F., Van- Cleave, A., Janga, M., Rickel, K., Evans C., Zhao, J., Zhang, E., and Tao, J.

Jill Weimer Publications  Johnson TB, White KA, Brudvig JJ, Cain JT, Langin L, Pratt MA, Booth CD, Timm DJ, Davis SS, Meyerink B, Likhite S, Meyer K, Weimer JM. AAV9 Gene Therapy Increases Lifespan and Treats Pathological and Behavioral Abnormalities in a Mouse Model of CLN8-Batten Disease. Mol Ther. 2020 Sep 24:S1525-0016(20)30490-1. doi: 10.1016/j.ymthe.2020.09.033. PMID: 33010819.  Centa JL, Jodelka FM, Hinrich AJ, Johnson TB, Ochaba J, Jackson M, Duelli DM, Weimer JM, Rigo F, Hastings ML. Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease. Nat Med. 2020 Sep;26(9):1444-1451. doi: 10.1038/s41591-020-0986-1. Epub 2020 Jul 27. PMID: 32719489  Langin L, Johnson TB, Kovács AD, Pearce DA, Weimer JM. A tailored Cln3Q352X mouse model for testing therapeutic interventions in CLN3 Batten disease. Sci Rep. 2020 Jun 29;10(1):10591. doi: 10.1038/s41598-020-67478-5. PMID: 32601357; PMCID: PMC7324379  Bajaj L, Sharma J, di Ronza A, Zhang P, Eblimit A, Pal R, Roman D, Collette JR, Booth C, Chang KT, Sifers RN, Jung SY, Weimer JM, Chen R, Schekman RW, Sardiello M. A CLN6- CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer. J Clin Invest. 2020 Aug 3;130(8):4118-4132. doi: 10.1172/JCI130955. PMID: 32597833; PMCID: PMC7410054  Dykstra JA, Blue ED, Negrão de Assis PL, Weimer JM, Kota DJ. Human adipose-derived stro- mal vascular fraction: characterization, safety and therapeutic potential in an experimental mouse model of articular injury. J Stem Cells Regen Med. 2020 May 27;16(1):16-25. doi: 10.46582/jsrm.1601004. PMID: 32536767; PMCID: PMC7282273  Johnson TB, Brudvig JJ, Lehtimäki KK, Cain JT, White KA, Bragge T, Rytkönen J, Huhtala T, Timm D, Vihma M, Puoliväli JT, Poutiainen P, Nurmi A, Weimer JM. A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease. Prog Neurobiol. 2020 Jun;189:101789. doi: 10.1016/j.pneurobio.2020.101789. Epub 2020 Mar 18. PMID:3219806  Uthoff J, Larson J, Sato TS, Hammond E, Schroeder KE, Rohret F, Rogers CS, Quelle DE, Dar- bro BW, Khanna R, Weimer JM, Meyerholz DK, Sieren JC. Longitudinal phenotype development in a minipig model of neurofibromatosis type 1. Sci Rep. 2020 Mar 19;10(1):5046. doi: 10.1038/s41598-020-61251-4. PMID: 32193437; PMCID: PMC7081358  Kohlmeyer JL, Kaemmer CA, Pulliam C, Maharjan CK, Samayoa AM, Major HJ, Cornick KE, Knepper-Adrian V, Khanna R, Sieren JC, Leidinger MR, Meyerholz DK, Zamba KD, Weimer JM, Dodd RD, Darbro BW, Tanas MR, Quelle DE. RABL6A Is an Essential driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tumor Cells to CDK4/6 Inhibitors. Clin Cancer Res. 2020 Jun 15;26(12):2997-3011. doi: 10.1158/1078-0432.CCR-19-2706. Epub 2020 Feb 21. PMID: 32086342; PMCID: PMC7299809

 Swier VJ, White KA, Meyerholz DK, Chefdeville A, Khanna R, Sieren JC, Quelle DE, Weimer JM. Validating indicators of CNS disorders in a swine model of neurological disease. PLoS One. 2020 Feb 19;15(2):e0228222. doi: 10.1371/journal.pone.0228222. PMID: 32074109; PMCID: PMC7029865  Johnson TB, Langin LM, Zhao J, Weimer JM, Pearce DA, Kovács AD. Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified Drinking water. Sci Rep. 2019 Oct 18;9(1):14962. doi: 10.1038/s41598-019- 51488-z. PMID: 31628420; PMCID: PMC6802212  Cain JT, Likhite S, White KA, Timm DJ, Davis SS, Johnson TB, Dennys-Rivers CN, Rinaldi F, Motti D, Corcoran S, Morales P, Pierson C, Hughes SM, Lee SY, Kaspar BK, Meyer K, Weimer JM. Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease. Mol Ther. 2019 Oct 2;27(10):1836-1847. doi: 10.1016/j.ymthe.2019.06.015. Epub 2019 Jul 10. PMID: 31331814; PMCID: PMC6822284  White KA, Cain JT, Magee H, Yeon SK, Park KD, Khanna R, Weimer JM. White KA, Cain JT, Magee H, Yeon SK, Park KD, Khanna R, Weimer JM. Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease. Neuronal Signal. 2019 Jun;3(2):NS20190001. doi: 10.1042/NS20190001. Epub 2019 Apr 8. PMID: 32269836; PMCID: PMC7104323  Khanna R, Moutal A, White KA, Chefdeville A, Negrao de Assis P, Cai S, Swier VJ, Bellampalli SS, Giunta MD, Darbro BW, Quelle DE, Sieren JC, Wallace MR, Rogers CS, Meyerholz DK, Weimer JM. Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1. Pain. 2019 Nov;160(11):2473-2486. doi: 10.1097/j.pain.0000000000001648. PMID: 31246731; PMCID: PMC6800626.  Moutal A, White KA, Chefdeville A, Laufmann RN, Vitiello PF, Feinstein D, Weimer JM, Khanna R. Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions. Mol Neurobiol. 2019 Oct;56(10):6736-6755. doi: 10.1007/s12035-019-1568-4. Epub 2019 Mar 27. PMID: 30915713; PMCID: PMC6728212 Grants  NIH/NIGMS (1P20GM121341-02). Transdisciplinary approaches to American Indian and Rural Population Health Research. Weimer, Jill (PI). 07/01/2017 – 05/31/2022. Role: PI  NIH/NICHD (1R25HD097633-01) . The Pediatric Biomedical Research Program. Weimer, Jill (PI). 01/01/2019-12/31/2023. Role: PI.  NIH/NINDS (1R01EY030183-01). Determining the role of CLN3 in the eye. Singh, Raluca (PI). 04/01/19-03/31/24. Role: Co-I  ForeBatten. Identifying potential molecular therapies for the treatment of CLN3-Batten disease (small molecules, anti-sense oligonucleotides). Weimer, Jill (PI). 05/06/2019-05/06/2021. Role: PI  Amicus Therapeutics. Development of novel therapies and preclinical tools for the treatment of rare pediatric diseases. Weimer, Jill (PI). 6/01/2019 – 12/31/2020 (renewed annually). Role: PI  Noah’s Hope. Characterization of a novel porcine model of CLN2 Batten disease. Weimer, Jill (PI). 10/01/2019-09/30/2022. Role: PI.  Stephen and Sandra Lehrman. Identifying potential molecular therapies for the treatment of CLN2-Batten disease. Weimer, Jill (PI). 05/01/2019-04/30/2021. Role: PI  NIH/NINDS (1R01NS113233-01). Antisense oligonucleotides for the treatment of CLN3 Batten Disease. Hastings, Michelle (PI). 05/01/2020 – 04/30/2025. Role: Co-I Presentations Oral  Charles River Neuroscience Discovery Webinar Series, May 13, 2020. A Translational Ap- proach to Monitoring Batten Disease.  Translational Research Conference for the management of NCLs, Lombard IL, November 7, 2019. A multimodal approach to identify clinically relevant parameters to monitor disease progression in preclinical models of lysosomal disorders.  BDSRA Annual Family Conference, Denver, CO; 07/20/19. Building preclinical tools for Batten disease.

 Conference for Int. Collaborative Forum for Gene Therapy of Genetic Diseases, Tokyo, Japan; 01/15/20. Combining Innovative Protein Engineering with Gene Therapy to Tackle Lysosomal Storage Disorders.  17th National NCL Congressy, Hamburg, Germany; 12/09/19. Therapeutic Strategies for CLN3- Batten Disease. Posters  23rd Annual Meeting of the American Society for Gene and Cellular Therapy (ASGCT). 5/12- 15/2020 (Virtual). Intracerebroventricular Delivery of AAV9 Gene Therapy Prevents Central and Retinal Neuron Loss, Preserving Vision in CLN6-Batten Disease Mice. White, KA, Nelvagal , HR, Poole, TA, Johnson, TB, Davis, S, Brudvig, J, Assis, AB, Meyer, K, Kaspar, BK, Wang, S, Cooper, JD, and Weimer, JM  23rd Annual Meeting of the American Society for Gene and Cellular Therapy (ASGCT). 5/12- 15/2020 (Virtual). Neonatal administration of scAAV9.CLN8 gene therapy prevents disease pathology and behavioral deficits in a mouse model of CLN8-Batten disease. Johnson, TB, Cain, JT, Pratt, M, Meyerink, B, White, K, Davis, S, Likhite, S, Meyer, K, and Weimer, JM.  2020 Virtual Neurofibromatosis Conference.NF1-associated cognitive impairment in a porcine model of Neurofibromatosis Type 1. Weimer, JM, Swier, VJ, White, KA, Negrao de Assis, P, Johnson, TB, Wallace, MR, Dodd, RD, Darbro, BW, Khanna, R, Roger, CS, Sieren, JC, Quelle, DE.  WORLD Lysosomal Congress, February 10-13, 2020. Neonatal administration of scAAV9.pT- MecP2.CLN8 gene therapy prevents disease pathology and behavioral deficits in a mouse model of CLN8-Batten disease. Johnson, TB, Cain, JT, Likhite, S, Meyerink, B, Davis, S, Swan- son, C, Staton, C, White, KA, Meyer, K, and Weimer, JM.  49th Annual Society for Neuroscience Meeting, October 19-23, 2019. The role of neurofibromin in neurocognitive impairment, CNS cell function, and differentiation in a porcine model of Neuro- fibromatosis Type 1 (NF1). Swier, VJ, White, KA, Negrao de Assis, P, Moutal, A, Khanna, R, and Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Combination of gene therapy and small molecule Drugs as a possible treatment for CLN6-Batten Disease. Swanson, C, Cain, JT, Johnson, TB, White, KA, Meyerink, BL, Davis, SS, Staton, CD, Pratt, MA, Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Analyzing sex-dependent differences in disease progression in mouse models of CLN3 and CLN8 Batten disease. Meyer- ink, BL, Zenner, ZP, White, KA, Johnson, TB, Davis, SS, Swanson, C, Booth, CD, Langin, LA, Pratt, MA, Timm, KJ, Cain, JT, Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019 and Eastern South Dakota Research Symposium: June 12, 2019. Cln6-BioID identifies protein cargoes within ER-associated vesicles. Booth, CB, Cain, JT, Johnson, TB, White, KA, Swanson, C, Brudvig, JJ, Lauf- mann, RN, May, D, Roux, KJ, Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019 and Eastern South Dakota Research Symposium: June 12, 2019. Longitudinal characterization of the Cln8mnd-/- mouse model of CLN8 Batten Disease - fine motor performance, brain pathology and metabolic changes. Lehtimäki, K, Bragge, T, Puoliväli, J, Rytkönen, J, Johnson, TB, Cain, JT, Davis, S, Nurmi, A, and Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Characterization of a novel porcine model of CLN3 Batten disease. Johnson, TB, Negrao de assis, P, Swier, VJ, White, KA, Sturdevant, DA, Drack, AV, Bhattarai, S, Rogers, C, Cooper, JD, Pearce, DA, and Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019 and Faculty for Undergrad- uates in Neuroscience (FUN) Symposium. Sec24d is required for collagen processing and neural development. Poppens, M, Cain, JT, Laufmann, R, Davis, S, Lu, C-L, Kim, J, and Weimer JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Intrathecal scAAV9-CLN3 administration rescues pathological and behavioral deficits and prolongs survival in a preclinical model of Batten disease. Pratt, MA, Johnson, TB, Likhite, S, Cain, JT, White, KA, Timm, D, Meyerink, BL, Davis, SS, Pineda, R, Dennys-Rivers, C, Meyer, K, Weimer, JM.

 49th Annual Society for Neuroscience Meeting: October 19-23, 2019. A CLN6-CRMP2-KLC4 complex regulates anterograde, ER-derived vesicle trafficking in cortical neurites. White KA, Cain J, Koh SY, Johnson T, Timm D, Sturdevant D, Hensley K, and Weimer JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Mesenchymal Stem Cells protect Purkinje cells and recover gait phenotype in a Ataxia-Telangiectasia swine model. Negrão de Assis, P, Dykstra, J, Kota, DJ, Cain, JT, Weimer, JM.  49th Annual Society for Neuroscience Meeting: October 19-23, 2019. Development of a quantita- tive approach for comprehensive analysis of rare disease biomarkers and progression in a preclinical model for CLN2 Batten Disease. Langin, L, Lehtimäki, K, Bragge, T, Brudvig, J, Johnson, TA, Timm, D, Nurmi, A, Pearce, DA, Puoliväli, J, and Weimer, JM.  ISN-ASN 2019 Meeting: August 4-8, 2019, Montreal. Effects of acidified Drinking water on motor behavior, neuropathology, and gut microbiota in a mouse model of Batten disease. Kovács, AD, Johnson, TB, Langin, LM, Zhao, J, Weimer, JM, Pearce, DA.

Professional, Clinical and Volunteer Service Sanford’s Research Division remains committed to the scientific community and public health at large through professional service, leadership and committee work within USD-SSOM, Sanford Re- search, Sanford Health, professional memberships, societies and scientific peer review processes. Individual faculty and their awards and professional service contributions are noted below in alphabetical order. Michelle Baack New Promotions/Appointments  Dr. Baack was promoted to Associate Scientist in Environmental Influences on Health and Dis- ease Group at Sanford Research and appointed as Sanford’s Division Chief of Research, De- partment of Pediatrics, USD-SSOM. USD-SSOM  USD-SSOM, Department of Pediatrics, Co-Division Chief Research, 2020-present  Medical School Admissions Committee, 2020-present  USD-SSOM Pediatric Residency Committee, 2011-present Sanford Research  Sanford’s Division Chief of Research, USD-SSOM, Department of Pediatrics  Sanford Profile Clinical & Scientific Advisory Board  Sanford Investigational Review Board #3. Role: Pediatric consultant Clinical Trial Leadership Dr. Baack is the Sanford Health site PI for NICHD-Neonatal Research Network and oversees the following NRN studies:  Cycled Phototherapy: A Safer Effective Method to Control Serum Bilirubin of Extremely Prema- ture Infants? 2020-present. Role: NRN Site PI and sub-I with Dr. Baiba Steinbreckera  Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal: a Function-Based Assessment and Management Approach (ESC-NOW Study). 2020-presnt. Role: NRN Site PI and sub-I with Dr. Jessica White.  Pragmatic, Randomized, Blinded Trial to Shorten Pharmacologic Treatment of Newborns with Neonatal Opioid Withdrawal Syndrome (NOWS). 2020-present. Role: NRN Site PI and sub-I with Dr. Akram Khan.  Randomized Controlled Trial of Home Therapy with Caffeine Citrate in Moderately Preterm In- fants with Apnea of Prematurity (MoCHA) Trial). 2019-present. Role: NRN Site PI and sub-I with Dr. Suzanne Reuter  Management of the Patent Ductus Arteriosus in Premature Infants (PDA) Trial. 2018-present. Role: NRN Site PI and sub-I with Dr. Baiba Steinbrekera  Darbepoetin to Improve Red Cell Mass and Neuroprotection in Preterm Infants and Reticulocyte Prediction Model add on study. 2018-present (finished enrolling in 2019, ongoing follow-up). Role: NRN Site PI and PI.  Milrinone in Congenital Diaphragmatic Hernia. 2017-present. Role: NRN Site PI and PI.  A Randomized Trial of Targeted Temperature Management with Whole Body Hypothermia for Moderate & Severe Encephalopathy in Premature Infants 33-35 Weeks Gestational Age and two

add on studies including MRI and EEG prediction models of NDI. 2017-present (finished enrolling in 2020). Role: NRN Site PI and co-I with Dr. Akram Khan.  Neurodevelopmental Effects of Donor Human Milk vs. Preterm Formula in ELBW infants (MILK Study). 2017-present. Role: NRN Site PI and co-I with Dr. Jessica White.  All Birth Cohort (ABC) Study. 2017-present. Role: NRN Site PI and PI.  Survey of Morbidity & Mortality among High Risk Preterm Infants (GDB). 2017-present. Role: NRN Site PI and PI.  Additional Clinical & Translational (Non-NRN) Studies:  AAP SONPM National Registry for Perinatal COVID-19 Infections. 2020-present. Role:PI  Feasibility of Cord Blood/Umbilical Cord Tissue Collection, Cryopreservation, Thawing, Cellular Analysis and Placental Tissue/Cellular Analysis. 2017-present. Role: PI  International Milk Bank Survey. 2017-present. Role: Sub-I with Dr. Simon Dyall, Bournemouth University, UK. Sanford Health  Predictors of adrenal insufficiency in VLBW infants; Conceptualized and initiated project with Co- I (Dr. Jacqueline Grev) and mentored students (Sarah Jackson, Pediatric Resident and Maya Gogoi, USD-SSOM medical student as part of T32 CHIRP Grant. 2019-present  Dandle Roo positioning blanket and the effectiveness of phototherapy in the NICU, Conceptual- ized and initiated project with PI (Baiba Steinbrekera) and USD-SSOM medical students. 2019- present Professional Societies and Memberships  Society for Pediatric Research (SPR), Member (Elected 2016)  Perinatal Research Society (PRS), Associate Member (Elected 2015), Full Member (Elected 2019)  Midwest Society for Pediatric Research (MSPR), Member (Elected 2012)  American Academy of Pediatrics (AAP), Section on Neonatal-Perinatal Medicine, Member  American Heart Association, Member  American Diabetes Association, Member Professional Service / Leadership  Associate Editor, American Journal of Perinatology  2022 Aspen-Snowmass Perinatal Biology Symposium Planning Committee  South Dakota Medicaid Advisory Board, Governor appointed position  South Dakota Medicaid Pharmacy & Therapeutics Committee, Governor appointed position Peer Review – Journals  Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), American Journal of Perinatol- ogy (AJP), Biology of Sex Differences (BOSD), Oxidative Medicine & Cellular Longevity, Journal of Molecular and Cellular Cardiology, European Journal of Clinical Investigation, Journal of Par- enteral and Enteral Nutrition (JPEN), Biology of Sex Differences (BOSD)

Entrepreneurship & Patents  Three-Dimensional Cross-Linked Scaffolds of Blood Plasma and Their Use. Provisional Patent, 2019 and full patent submission June 13, 2020. De la Puente P; Baack, M; Bhatacharya, S; Gandy, T and Calar, K. Community / Outreach  Collaborations in Cardiac Research. Sanford Health News, Sioux Falls, SD

Indra Chandrasekar Sanford Research  Institutional Biosafety Committee, Member Peer Review  American Society for Cell Biology, Abstract Reviewer for annual meeting  International Journal of Molecular Sciences, Cells

Randolph Faustino Sanford Research  Director, Sanford PROMISE Scholars Program, Sanford Research. Leadership role includes oversight on all aspects of the PROMISE Scholars Program. This includes program design, content, administration, and recruitment. Sept 2019 – present Professional Service  Guest Editor, Cells. Responsible for establishing aim and scope of a special issue of Cells focused on the theme of Cardiac Diseases and Stem Cell Modeling (provisional). Aug 2020 (ongoing)  Editorial Board Member (Review Editor), Frontiers in Physiology (Striated Muscle Physiology Section). Roles include reviewing journal submissions to ensure proper scientific rigor, engaging with the authors, Associate Editor and other Review Editors. June 2020 – present Peer Review – Journals  Clinical Pharmacology and Therapeutics, Bioinformatics, Nature Clinical Practice Cardiovascular Medicine, BMC Genomics, Scientific Reports, Cells, Molecular Biology Reports, Stem Cells In- ternational, Current Bioinformatics, International Journal of Molecular Sciences, Applied Sci- ences, Development, Pharmaceuticals

Kevin Francis Awards  NIH Loan Repayment Award for Pediatric Research, NCATS, 2019 - 2020  Best Poster Award, Bethany Freel, USD CBBRe Annual Symposium, 2019  USD Center for Brain and Behavior Research Travel Award, Ruthellen Anderson and Jordan Sheets, 2019 USD-SSOM  USD Basic Biomedical Sciences (BBS) Graduate Committee. Role: Member  USD-SSOM Research Committee. Role: Member  USD BBS Graduate Student Committee. Role: Faculty Advisor  USD Center for Brain and Behavior Research. Role: Peer Reviewer Sanford Research  Sanford Research Graduate Research committee. Role: Member  Sanford Research Seminar Series coordinator. Role: Member  Sanford Program for Undergraduate Research (SPUR). Role: Selection Committee Member  Sanford Research Coordination of Rare Diseases (CoRDS) Scientific Advisory Committee. Role: Member Professional Service  Smith-Lemli-Opitz/RSH Foundation Medical Advisory Board  IMAGEN: Biomaterials in South Dakota, Research & Development Collaboration Grant from SD Board of Regents. Role: Advisory Board Member  Society for Neuroscience. Role: Member  International Society for Stem Cell Research. Role: Member Peer Review – Journals  PLOS Genetics, Scientific Reports, Journal of Steroid Biochemistry and Molecular Biology, Cel- lular and Molecular Life Sciences, International Journal of Medical Sciences Community / Outreach  Community outreach activities through the PROMISE Lab at Sanford Research, including presentations to elementary, middle school, and high school students, as well as research shadow opportunities for high school and college students.

Kurt Griffin New Promotions and Appointments  Dr. Griffin was appointed to the Todd & Linda Broin Chair for Diabetes Research and promoted to Scientist at Sanford Research in the Diabetes Group.

USD-SSOM  USD-SSOM, Department of Pediatrics Research and Education Committee, 2014-present.  USD Pediatrics Mentoring Committee: July 2015-Present Sanford Research  Sanford Research IRB-3. April 2014–Present  Sanford Research Faculty Search Committee. April 2014–Present  Sanford Research Faculty Leadership and Promotions Committee. August 2016–Present  Sanford-Mayo pediatric symposium steering committee. 2016–Present  Sanford Research Pediatric COBRE Internal Advisory Committee. 2016–Present  Sanford Research Population Health COBRE Internal Advisory Committee. 2016–2019 Clinical Trial Leadership  NCT00097292. Diabetes TrialNet. April 2013 – Present. TrialNet Natural History Study of the De- velopment of Type 1 Diabetes (TN-01). Role: Site PI  NCT02293837. Immune Tolerance Network. November 2014 – Present. EXTEND: Preserving Beta-Cell Function with Tocilizumab in New-onset Type 1 Diabetes. Role: Site PI  NCT02734277. Immune Tolerance Network. July 2017 – Present. Type 1 Diabetes Extension Study (TIDES). Role: Site PI  NCT02748018. CEP-304, Medtronic, Inc. Multi-center, randomized, parallel, adaptive, controlled trial in adult and pediatric patients with type 1 diabetes using hybrid closed loop system and control (CSII, MDI and SAP) at home. Role: Site PI  NCT03751007. Inrexon, Inc. Intrexon AG019-T1D-101: A prospective, multi-center, Phase 1b/2a study to assess the safety and tolerability of different doses of AG019 administered alone or in association with teplizumab in subjects with clinical recent-onset Type 1 Diabetes Mellitus (T1D). Role: Site PI.  NCT03875729. Provention Bio, Inc. July 2019 – Present, PROTECT: Provention Bio’s T1D Trial Evaluating C-Peptide with Teplizumab” NCT03875729. Role: Site PI.  NCT03929601. Diabetes TrialNet. TN-25: RAPTOR: Rituximab Followed by Abatacept for Pre- vention or Reversal of Type 1 Diabetes. Study-wide enrollment suspended pending COVID-19 considerations. Role: Study start up 2020, Site PI.  NCT03428945. Diabetes TrialNet. Anticipate opening in Fall 2020. TN-22: Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus. Role: Study start up 2020, Site PI. Sanford Health  Population screening for Type 1 Diabetes and Celiac disease. Launched August 2020.  Sanford Enterprise Diabetes Council: 2016–Present Professional Service  Pediatric Endocrine Society: Diabetes Special Interest Group, 2018 – Present. Role: Co-Chair (Lawson Wilkins)  Helmsley Charitable Trust / Milken Institute. Role: Advisory board member for Type 1 Diabetes screening program development Peer Review – Journals  Journal of Clinical Endocrinology and Metabolism, Endocrine-Related Cancer, Molecular Endo- crinology, PLoS One Community / Outreach  City of Sioux Falls Bicycle Committee. 2014-Present  Safe Cycling  Instructor (one of 5 in SD certified by the League of American Bicyclists): 2014-Present.

Michael Kareta Sanford Research  Sanford Foundation Pilot & Feasibility Grant Review Committee (ad hoc) Sanford Health  Sanford Health Genomics Tumor Boards, Member, Genomics Advisor (twice weekly) Professional Service  UND Dakota Cancer Collaborative on Translational Activity (DaCCoTA) Scholars Grant (ad hoc)

 UND Dakota Cancer Collaborative on Translational Activity (DaCCoTA) COVID-19-Related Pilot Grant (ad hoc) Peer Review – Journals  Oncogene, Scientific Reports, British Journal of Cancer, Communications Biology Community / Outreach  PROMISE Lab, volunteer instructor

Attila Kovacs Sanford Research  Sanford IACUC Committee. Role: Member, Chair

Lance Lee USD-SSOM  Promotions Primary Review Committee, Department of Pediatrics  Research & Scholarship Day Abstract Review Committee, Department of Pediatrics  Graduate Committee, Basic Biomedical Sciences a. G-RISE T32 Executive & Admissions Committee, Basic Biomedical Sciences  Advisory Board, Health Sciences Major Sanford Research  Director of Higher Education  Director, Sanford Program for Undergraduate Research (SPUR)  Sanford Program for Undergraduate Research (SPUR) Selection Committee (Chair)  Graduate Student Recruitment Committee (Chair)  Student Diversity & Inclusion Committee  Post-Graduate Professional Development Committee  Sanford fit/PROMISE Steering Committee  Eastern South Dakota Research Symposium Organizing Committee (Chair)  Coordinator, Sanford Research Responsible Conduct in Research Seminar Series  Coordinator, Sanford Research Graduate Student-Invited Seminar Series Professional Service  Graduate Advisory and Research Committee, Department of Chemistry & Biochemistry, SDSU Professional Society Membership  American Society for Cell Biology  American Thoracic Society  International Mammalian Genome Society (through 2019)  South Dakota Academy of Science (through 2019) Peer Review - Journals  Science, Disease Models and Mechanisms, Neurology: Genetics, Journal of Human Genetics, PLOS Genetics, Andrologia Peer Review - Grants  Hydrocephalus Association, USA  Biotechnology and Biological Sciences Research Council, United Kingdom Community / Outreach  Sanford Research Responsible Conduct in Research Series: “Engaging with the Community”. 2019  Sanford Research manuscript writing workshop: “Basics of Scientific Writing: Writing with Clar- ity”. 2019.  Educational presentation to Sanford IRB: “An Introduction to Genetics”. 2020.

Santiago Lopez Sanford Research Clinical Trial Leadership Study submission and start-up:  Seqirus: Comparison of Inactivated Cell based vs Egg based Influenza vaccine

 DaCCoTa Pilot-COVID-19: Comparison of antibodies against SARS-CoV-2 in cancer and non- cancer pediatric patients in South Dakota  Pfizer: Evaluation of Streptococcus pneumonia colonization and COVID-19 Sanford Health  Unit-based Safety program for central line infection reduction; Sanford Health, Sioux Falls, SD. Role: Member, Chair  Antimicrobial Stewardship, Sanford Children’s Hospital, Sioux Falls, SD. Role: Co-Director Peer Review - Journals  Journal of the Pediatric Infectious Diseases Society, AAP, Pediatrics Community / Outreach External Advisor for the Sioux Falls School District

Samuel Milanovich Sanford Research  Sanford Research Institutional Biosafety Committee (IBC, January 2015 – September 2019, ad- hoc member October 2019-present)  Sanford Regenerative Medicine Initiative (February 2015 – present). Role: Steering committee member  Sanford Cancer Genomics Steering Committee (May 2016 – present) to guide Sanford Cancer Center in most effectively incorporating the evolving field of genomics into clinical cancer care. Role: Steering committee member  Sanford Children’s Genomic Medicine Consortium (April 2015 – present). This is a national consortium of children’s hospitals to advance clinical genomic applications in the field of pediatrics. Role: Research committee member  Clinical Research Leadership  Children’s Oncology Group, Sanford Health Fargo. Role: Institutional PI, open and oversee the conduct of therapeutic, biologic and observational studies in this international childhood cancer research consortium  Cancer Stem Cells in Childhood Leukemia, Sanford Research. Translational research project developing a clinically annotated biorepository of leukemia specimens from children and young adults diagnosed with leukemia. Role: PI  AML16, National Collaborative Clinical Trial consisting of 10 children’s hospitals for children and young adults with newly diagnosed AML. Role: Institutional PI  CTR CAR T-cells: Biomanufacturing of Safe and Non-Viral CAR T-cells for Cancer Immunother- apy. Collaborative study between Sanford Research and North Dakota State University investigating novel mechanisms for leukemia immunotherapy. Role: Co-I  COMPASS: Clinical Oncology Observational Study in Sanford Adult and Pediatric Cancer Pro- grams to use molecular profiling of tumors to provide “personalized” cancer treatment. Role: Co- PI (PI: Powell)  OncoKids: Next-Generation Sequencing of Pediatric Tumor Samples from a Multi-Institutional Consortium of Clinical Cancer Programs. Multi-institutional study to discover novel genomic alterations and determine the impact of next generation molecular profiling in the treatment of rare and refractory pediatric tumors. Role: Institutional PI  Chemotherapy Induced Peripheral Neuropathy in Developmentally Delayed and Younger Chil- dren with Cancer. We aim to describe the incidence of chemotherapy-induced peripheral neuropathy in at risk pediatric oncology patients and develop a scoring tool to quantify neuropathy and measure response to intervention. Role: Co-I  A Randomized Open-Label, Active Controlled, Safety and Descriptive Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event (Pfizer). Industry study investigating safety and efficacy of new generation anticoagulant medication in adolescents, children, infants and neonates. Role: Institutional PI  Evaluation of Long-Term Safety in Paediatric Patients with B-Precursor Acute Lymphoblastic Leukemia Who Have Been Treated with Blinatumomab or Chemotherapy, Followed by Trans- plantation. Industry registry study of long-term outcomes for patients treated with blinatumomab who go on to transplant. Role: Institutional PI: 20180130

Professional Service  Molecular Tumor Board, TAPUR Trial, American Society of Clinical Oncology. Pediatric oncolo- gist on a national tumor board to provide recommendations based on genomic testing in childhood cancer patients enrolled on this study. (September 2017 – present) Peer Review – Journals  Bioscience Reports, Epigenomics Peer Review - Grants  Biomedical Research Centre, Rare Diseases Cohort Theme, Great Ormond Street Hospital, Lon- don, UK. Role: Ad hoc grant peer reviewer Sanford Health  Sanford Physician’s Care Committee (January 2015 – September 2019). Role: Member  Sanford Blood Product Utilization Committee (Sioux Falls, January 2015 – September 2019). Role: Member

Thayne Munce USD-SSOM  Sanford Black Hills Pediatric Symposium Planning Committee. Role: Member  USD Center for Brain and Behavioral Research (CBBRe) Steering Committee. Role: Member Sanford Health  Sanford Sports Medicine Symposium Planning Committee, Sanford Orthopedics and Sports Medicine, Sioux Falls, SD. Role: Planning Committee Member  Helped develop DXA body composition offering at Sanford USD Medical Center Professional Service  American College of Sports Medicine. Role: Fellow  Northland Chapter of the American College of Sports Medicine. Role: Member  Sports Medicine Advisory Committee, South Dakota High School Activities Association (SDHSAA). Role: Member  Leadership Board, National Youth Sports Health and Safety Institute (NYSHSI). Role: Member  Strategic Health Initiative (SHI) - Youth Sports and Health Committee, American College of Sports Medicine. Role: Member Peer Review Abstract Reviewer, Northland Chapter of the American College of Sports Medicine, Student Poster Competi- tion Community / Outreach  Expert Commentator / Creative Director, Science of Sports series, Midco Sports Network, Sioux Falls, SD  Expert Interview – “Build Your Base with Beef”, May 20, 2020, Cattle Business Weekly (Online), Philip, SD  Featured Guest – “Sports Training, Injuries and Recovery”, May 5, 2020, KELOLAND Living, KELO TV / Online, Sioux Falls, SD  Featured Guest – “Cognitive and Sports Vision Training”, April 14, 2020, Calling All Sports, KWSN Radio, Sioux Falls, SD  Featured Studio Guest – “Readiness and Recovery in Basketball”, March 3, 2020, Midco Sports Network, Sioux Falls, SD  Expert Interview – “Sanford Health Might Conduct Research on Fighters it Pays. Here’s Why That Could Be a Problem”, November 7, 2019, Inforum (Online), Fargo, SD  Expert Interview – “Football Participation Declines in S.D. and U.S. as Brain Injury Research Ex- pands”, October 2, 2019, SD News Watch (Online), Sioux Falls, SD  Expert Interview, “Build Your Base with Beef”, August 28, 2019, Healthbeat, KELO TV Evening News, Sioux Falls, SD  Featured Studio Guest – “NSAF Performance Clinics”, August 9, 2019, Innovations, South Da- kota Public Radio, Sioux Falls, SD  Featured Guest – “Youth Football Research”, August 8, 2019, Overtime with Jeff Thurn, ESPN 99.1 Radio, Sioux Falls, SD

 Featured Studio Guest, “Sports Science Research”, August 10, 2019, A Better You, KSOO Ra- dio, Sioux Falls, SD

David Pearce Sanford Research  President, Innovation, Research and World Clinics  Transdisciplinary approaches to American Indian and rural population health research CoBRE, Sanford Research, 2017-2022. Role: Internal Advisory Committee Professional Service & Leadership  RxRE Leader Forum, 2020-present. Role: Member  RARE-X, 2019-present. Role: Board Member, Scientific Advisory Board  Haley’s Heroes Foundation at The Giving Back Fund, 2018-present. Role: Scientific Advisory Board Member  ForeBatten, 2018-present. Role: Chair, Scientific Advisory Board  CureBatten CLN8 – Sebastian Velona Foundation at The Giving Back Fund, 2017-present. Role: Scientific Advisory Board  Fight for Batten Foundation, 2017-present. Role: Member, Chair of the Scientific Advisory Board  Beat Batten’s Foundation, 2017-present. Role: Scientific Advisory Board  Clinical Center of Excellence for Rare Diseases, Perth Children’s Hospital, 2020-present. Role: Board Member  Alliance for Cell Therapy Now (ACT-NOW), 2018-present. Role: Board Member  Developmental Research Program for Medical Students grant, T35, South Dakota, 2017-present. Role: Member, Internal Advisory Committee  Sanford Stem Cell Consortium, 2017-present. Role: Scientific Advisory Board  National Registry for Cell Therapy, 2017-present. Role: Steering Committee Member  Dakota Lions Sight and Health, 2017-2019. Role: Board Member  North Dakota Established Program to Stimulate Competitive Research (ND Epscor), Fargo, ND, 2020  Fifth International Vatican Conference – Exploring the Mind, Body & Soul, Unite to Present & Unite to Cure, Vatican City, 2020. Role: Steering Committee  IRDiRC Working Group 3: Methodologies that Impact Diagnosis and Treatment, Paris, 2020. Role: Chair  World Stem Cell Summit, Miami, USA, 2020. Role: Advisory Board  Forum Research, virtual event, July 2020. Conducting Clinical Trials Amid COVID-19 Working Group.  Alliance for Cell Therapy Now (ACT-NOW), virtual event, September 2020. Roundtable Partici- pant “Exploring Public Policy: Regenerative Medicine and Cell Therapies”  Advanced Therapies Congress & Expo 2020, London, April 2020. Session Chair “Innovation Track”  Rare Diseases and Orphan drugs Congress, Buenos Aires, March 2020. “The International Rare Diseases Research Consortium (IRDiRC): Reaching out to Policy Markers on Rare Diseases” and “Team Science: Integrating Natural Histories into EHRs for more Accurate Diagnosis”  RE(ACT) Congress and IRDiRC Conference 2020, Berlin, March 2020. Session Chair “Method- ologies to Assess the Effect of Diagnosis and Therapies on RD Patients”  Alliance for Cell Therapy Now (ACT-NOW)/Bipartisan Policy Center Roundtable on Regenerative Cell Therapies, Washington D.C., January 2020. Roundtable Participant “Regenerative Medi- cine: Real-World Evidence to Measure Outcomes and Support Regulatory, Payment and Other Decision-Making”  World Stem Cell Summit, Miami, January 2020. Session Chair “Update from the Innovators – Neurology and Aging Diseases” Peer Review – Grants  Ad Hoc reviewer, ZNS1 SRB-T (43) SEP (March 2020)  NCATS Special Emphasis Panel PAR-18-952 and PAR-18-953 (September 2019)

Kyle Roux Sanford Research  Senior Director, Sanford Research Professional Service  Journal Editorial Board, Cells, 09/03/2019-present Peer Review – Journals  Invited referee for numerous journals with an estimated 35 articles reviewed Peer Review – Grants  Israeli-US Binational Science Foundation (02/2020)  NIH Pioneer Award Program (01/2020)

Alexei Savinov Sanford Research  Flow Cytometry Core. Role: Director  Data Club committee. Role: Co-Chair Professional Memberships  American Association of Immunologists. Role: Member  American Diabetes Association. Role: Member  Immunology of Diabetes Society. Role: Member Peer Review – Journals  Diabetologia, Diabetes, Journal of Immunology, PLOS One, JBC, Molecular Endocrinology Peer Review – Grants  DOD US Army Medical Research and Materiel Command (USAMRMC) Congressionally Di- rected Medical Research Programs (CDMRP). Role: Study Section Member

Arielle Selya Awards  Loan Repayment Program for Pediatric Research (LRP-PR) Renewal Award, NIDA (NIH), “Esti- mating causal effects of maternal smoking on youth smoking outcomes” ($13,094 awarded; 7/1/2019 – 6/30/2020). USD-SSOM  Sanford Research Postdoctoral Professional Development Committee. Role: Member, 01/2019 – 07/2020  Sanford Research Recruitment Committee. Role: Member, 06/2019 – 07/020  Sanford fit/PROMISE Steering Committee. Role: Member, 06/2019 – 07/2020  Sanford SPUR Admissions Committee. Role: Member, 06/2019 – 07/2020 Sanford Research  Data Exchange Core. Role: Director Professional Service Professional Memberships  System Dynamics Society  Society for Nicotine and Tobacco Research Peer Review – Journals  Addiction, Addictive Behaviors, Medical Informatics and Decision Making, BMC Public Health, BMJ Open, Drug and Alcohol Dependence, F1000Research, Health Psychology, Journal of Ad- diction Medicine, Journal of Studies on Alcohol and Drugs, Medicina, Nicotine & Tobacco Re- search, Nutrients, Preventive Medicine, Tobacco Use Insights Community / Outreach  Oxford University Press news release, November 4, 2019. URL: https://www.eure- kalert.org/pub_releases/2019-11/oupu-sft110119.php  Bloomberg Quint web article, November 4, 2019. URL: https://www.bloombergquint.com/business/vaping-s-role-as-gateway-to-teen-smoking-questioned-in-study  CNN web article, November 4, 2019. URL: https://www.cnn.com/2019/11/04/health/vaping- smoking-gateway-study/index.html  CBS News Radio, pre-recorded interview, November 4, 2019

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 KCBS Radio, live interview, San Francisco, CA, November 4, 2019

Kameswaran Surendran Sanford Research  Graduate Student Selection Committee Member  IACUC Scientific Member  Internal Advisory Committee Member for Pediatrics CoBRE  Faculty Leadership and Promotions Committee Member  Co-Director of Functional Genomics and Bioinformatics Core  Faculty Search Committee Professional Service  American Society of Nephrology (ASN) 2019 Annual Meeting Abstract Reviewer for “Develop- ment, Stem Cells, and Regenerative Medicine” category  ASN Co-moderator of “Development and Stem cells” session, Washington DC, 2019 Professional memberships:  American Society of Nephrology  American Academy for the Advancement of Science  American Physiological Society Peer Review – Journals  American Journal of Physiology-Renal, Cells, Epigenetics, Histology and Histopathology, Journal of American Society of Nephrology, Kidney International, Scientific Reports Peer Review – Grants  NIDDK Special Emphasis Panel Grant Reviewer

Jianning Tao USD-SSOM  USD-SSOM Department of Pediatrics, Grand Rounds Reviewer Panel (research representative)  USD Sanford School of Medicine SSOM faculty grants reviewer Sanford Research  Sanford Research IBC Committee, 09/2019- present. Role: Member  Diversity of Graduate Student Education Committee. Role: Chair, Member  Sanford Research Faculty Search Committee, Role: Member Peer Review – Journals  Nature Cell Biology, OncoTargets and Therapy, BONE Peer Review – Grants  Geographical Management of Cancer Health Disparities Program, NCI; GMaP6 Pilot Grant Pro- gram, Region 6. Role: Grant Reviewer

Jill Weimer USD-SSOM  USD-SSOM Faculty Development Committee. Role: Member, 7/2017-Present  USD-SSOM, Department of Pediatrics Awards Committee. Role: Member, 5/2018; 5/2020  USD-SSOM Student Progress and Conduct Committee. Role: Member, 7/13- 6/2016; 7/2017 – 8/2019 Sanford Research  Center for Pediatric Research (NIH CoBRE) Internal Advisory Committee. Role: Member, 4/15- present  Coordination of Rare Diseases at Sanford (CoRDS) Advisory Committee. Role: Member, 1/18- present  Faculty Appointment and Promotions Committee. Role: Member, 3/2015-Present  Faculty Advisory Committee. Role: Member, 3/2018-Present  Faculty Search Committee. Role: Member, 01/11-Present Professional Service

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 Society for Neuroscience Annual Conference 2020 – Mini-sympsium “RASopathies: Pathophysi- ology and Therapeutic Directions”. Role: Symposium Co-Chair, (Delayed to 2021 due to COVID- 19 Pandemic)  NIH Workshop on Validation of Animal Models and Tools for Biomedical Research. Role: Confer- ence Co-Organizer/Session Chair, 12/8-9/2020 (Virtual)  5th Translational Research Conference for the management of the NCLs. Role: Conference Or- ganizer/Chair, 11/7-8/2019  Children’s Tumor Foundation NF Conference, San Francisco, CA. Role: Conference Organizing Committee/Co-Chair, 11/21-24/2019 Peer Review – Journals  Molecular Psychiatry, Orphanet Journal of Rare Disease, Journal of Visualized Experiments, PLOS ONE, Frontiers in Cellular Neuroscience, Molecular Neurobiology, Brain Peer Review – Grants  NIH Neurodevelopment, Synaptic Plasticity, and Neurodegeneration Study Section (F03A). Role: Review Committee Member, 7/2017-present  MSD Action Foundation, Ireland. Role: Reviewer, 3/2020  Children’s Tumor Foundation’s Drug Discovery Initiative Grant. Role: Reviewer, 2/2020 Community / Outreach  Children’s Tumor Foundation Shine a Light Walk for South Dakota. Role: Honorary Chair, 2020  Don’t Forget Morgan (BPAN Foundation). Role: Scientific Advisory Board, 2020-present  ForeBatten (CLN3 Batten Foundation). Role: Scientific Advisory Board, 2019-2020

AVERA

Jyoti Angal

Scholarly Activity Publications  Kozak, K, Greaves, A, Waldfogel, J, Angal, J, Elliott, AJ, Fifer, WP, & Brito, NH (in press). Paid maternal leave is associated with better language and socioemotional outcomes during toddler- hood. OSF Preprints. https://doi.org/10.31219/osf.io/kp4tg.  Shuffrey, LC, Myers, MM, Isler, JR, Lucchini, M, Sania, A, Pini, N, Nugent, JD, Condon, C, Ochoa, T, Brink, L, de Plessie, C, Odendaal, HJ, Nelson, ME, Friedrich, C, Angal, JA, Elliott, AJ, Groenewald, C, Burd, L, Fifer, WP for the PASS Network. (2020). Association between prenatal exposure to alcohol and neonatal brain activity: results from the Safe Passage Study. JAMA Net- work Open, 3(5):e204714.  Acosta, L, Rauh, V, Angal, J, Friedrich, C, Ye, P, Myers, M, Fifer, W, Elliott, AJ, & Perzanowski, M. (2020). Respiratory emergency department visits more common among Native American children than non-Native American in South Dakota. Journal of Allergy and Clinical Immunology, 145(2), AB112.  Ye, P, Angal, J, Tobacco, D, Willman, A, Friedrich, C, Nelson, M, Burd, L, & Elliott, AJ. (2020). Risk factors for prenatal drinking in the Northern Plains: differences between American Indian and Caucasian mothers. American Journal of Preventive Medicine. 58(4), e113-e121. PMID: 32061456.  Elliott, AJ*, Kinney, HC*, Haynes, RL, Dempers, JD, Wright, C, Fifer, WP, Angal, J, Boyd, TK, Burd, L, Burger, E, Folkerth, RD, Groenewald, C, Hankins, G, Hereld, D, Holm, IA, Hoffman, HJ, Myers, MM, Nelsen, LL, Odendaal, HJ, Petersen, J, Randall, BB, Roberts, DJ, Robinson, F, Schubert, P, Sens, MA, Sullivan, LM, Tripp, T, Van Eerden, P, Waddee, S, Willinger, M, Saharie, D, Dukes, KA for the PASS Network. Concurrent prenatal drinking and smoking increases the risk for SIDS: Report of the Safe Passage Study (* Elliott & Kinney co-primary authors). (2020). Lancet EClinicalMedicine, 19, 100247. PMID: 32140668.  Goldstein, RD, Petty, CR, Morris, SE, Human, M, Odendaal, H, Elliott, AJ, Tobacco, D, Angal, J, Brink, L, Prigerson, HG, and the PASS Network. (2020). Transitional objects of grief. Compre- hensive Psychiatry. Available online 11 January 2020, https://doi.org/10.1016/j.comppsych.2020.152161. PMID 31978784.

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Grants Awarded  South Dakota Pediatric Clinical Trials Network (SoDakPCTN) UG1OD030019 Source: NIH/Office of the Director Start & End Dates: 09/01/2020 – 08/31/2025 Funding: $1,904,664 Multi-P.I.: Amy Elliott, Ph.D. & Katherine Wang, MD Role: Co-Investigator Project Statement: The purpose of the South Dakota Pediatric Clinical Trials Network (So- DakPCTN) is to leverage the enthusiasm and growth in pediatric research over the last decade to build regional capacity and skills in clinical trials.

 Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort – Phase II (UH3 OD023279) Supplement – Ethics Source: NIH/Office of the Director/Office of Women’s Health Supplement PI – Jyoti Angal, MPH Grant PI – Amy Elliott, PhD Project Statement: The overall goal of this proposal is to explore factors affecting return of individual results to participants. The grant will explore whether participants perception of risk associated with accepting induvial results of research is different those of IRBs and investigators.

Presentations Local  Angal J. (October 2020). South Dakota Pediatric Clinical Trial Network. Presentation to the Avera Pediatric Steering Committee. National  Angal, J. (July 2020). Exploring the Principles of Justice in research: Considerations for Tribal communities. Secretary’s Advisory Committee on Human Research Protections. July  Angal J. (August 2020). Return of Research Results. Environmental Child Health Outcomes Ad- visory Board Abstracts  Angal Acousta, LM, Rauh, VA, Angal, J, Friedrich, C, Ye, P, Myers, MM, Fifer, WP, Elliott, AJ, Perzanowski, MS. Respiratory emergency department visits more common among Native Ameri- can children than non-native American in South Dakota. Submitted to AAAAI annual conference.

Arielle R Deutsch, PhD Scholarly Activity Publications  Deutsch, A. R. & Deutsch, A. S. (in press) Stability in effects of different smoking-related polygenic risk scores and associated phenotypes. Drug and Alcohol Dependence  Deutsch, A. R. & Deutsch, A. S. (in press) Dynamic change in the association of a cigarettes- per-day polygenic risk score across the numeric range of its corresponding phenotype over adolescence and young adulthood. Addictive Behavior.

Grants Awarded  Title: Community Based System Dynamics Models of Alcohol and Substance Exposed Preg- nancy in Northern Plains American Indian Women Source: NIH (NIDA) Start & End Dates: 2020 –2024 P.I.: Arielle R. Deutsch

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 Title:Leverage Points for Equitable Systemic Change to Reduce Alcohol Exposed Pregnancy Source: NIH (NIGMS) Center PI: Jill Wiemer Project PI: Arielle R. Deutsch 2021 – 2022 Presentations  Deutsch, A. R. (March 2020). Alcohol facilitated violence over adolescence and young adulthood: Examining interactions with alcohol misuse and violent behavior. Paper presented at the Society for Research on Adolescence, Minneapolis MN. (Conference Canceled)  Deutsch, A. R, Lustfield, R. & Mohammad, M. S. (2020) Community-based system dynamics modeling of sensitive public health issues: Maximizing diverse representation of target populations with personal experiences. System Dynamics Society Annual Conference, Formerly Oslo, Norway, Virtual Forum  Deutsch, A. R, Lustfield, R. & Mohammad, M. S. (2020) Community-based system dynamics modeling for alcohol misuse and intimate partner violence disparities: The importance of “lived system” narratives. Research Society on Alcoholism, (Conference Canceled) Service Professional Editor  Developmental Psychology, Consulting Editor Committee Service  Member, Great Plains IDeA Community Translational Research Community Advisory Board  Member, Oglala Lakota Children’s Justice Center Advisory Board  Member, Interdisciplinary Research Committee, Society of Research on Adolescence

Amy J Elliott, PhD

Teaching Mentoring  Internal Medicine Residents, University of South Dakota School of Medicine  Nevada Sorenson (Pathways), USD Sanford School of Medicine  Kenzie Lee (Pathways), University of South Dakota School of Medicine Scholarly Activity Publications  Kozak, K, Greaves, A, Waldfogel, J, Angal, J, Elliott, AJ, Fifer, WP, & Brito, NH (in press). Paid maternal leave is associated with better language and socioemotional outcomes during toddler- hood. OSF Preprints. https://doi.org/10.31219/osf.io/kp4tg.  Bush, N, Wakschlag, LS, LeWinn, K, Hertz-Picciotto, I, Nozadi, S, Lewis, J, Biezonski, D, Blair, C, Deardorff, J, Neiderhiser, J, Leve, L, Elliott, AJ, Duarte, C, Lugo-Candalas, C, O’Shea, M, Av- alos, L, Page, G, & Posner, J. (2020). Family environment, neurodevelopmental risk, and the En- vironmental Children’s Health Outcomes (ECHO) initiative: Looking back and moving forward. Frontiers in Psychiatry, 11(547). doi: 10.3389/fpsyt.2020.00547.  Blackwell, CK, Hartstein, LE, Elliott, AJ, Forrest, C, Ganiban, J, Hunt, K, Camargo, C, LeBour- geois, MK on behalf of program collaborators for Environmental influences on Child Health Out- comes (ECHO). (2020). Better sleep, better life?: How sleep quality influences school-age children’s life satisfaction. Quality of Life Research. https://doi.org/10.1007/s11136-020-02491-9.  Shuffrey, LC, Myers, MM, Isler, JR, Lucchini, M, Sania, A, Pini, N, Nugent, JD, Condon, C, Ochoa, T, Brink, L, de Plessie, C, Odendaal, HJ, Nelson, ME, Friedrich, C, Angal, JA, Elliott, AJ, Groenewald, C, Burd, L, Fifer, WP for the PASS Network. (2020). Association between prenatal exposure to alcohol and neonatal brain activity: results from the Safe Passage Study. JAMA Net- work Open, 3(5):e204714.  Acosta, L, Rauh, V, Angal, J, Friedrich, C, Ye, P, Myers, M, Fifer, W, Elliott, AJ, & Perzanowski, M. (2020). Respiratory emergency department visits more common among Native American children than non-Native American in South Dakota. Journal of Allergy and Clinical Immunology, 145(2), AB112.

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 May, PA, Hasken, JM, Stegall, JM, Mastro, HA, Kalberg, WO, Buckley, D, Brooks, M, Hedrick, DM, Ortega, MA, Elliott, AJ, Tabachnick, BG, Abdul-Rahman, O, Adam, MP, Robinson, LK, Man- ning, MA, Jewett, T, & Hoyme, HE (2020). Fetal alcohol spectrum disorders in a Southeastern county of the United States: Child characteristics and maternal risk traits. Alcoholism: Clinical and Experimental Research, 44(4), 939-959. PMID: 32293734.  May, PA, Hasken, JM, Bozeman, R, Jones, JV, Burns, MK, Goodover, J, Kalberg, WO, Buckley, D, Brooks, M, Ortega, MA, Elliott, AJ, Hedrick, DM, Tabachnick, GB, AbdulRahman, O, Adam, MP, Jewett, T, Robinson, LK, Manning, MA, & Hoyme, HE. (2020). Fetal alcohol spectrum disorders in a rocky mountain region city: Child characteristics, maternal risk traits, and prevalence. Alcoholism: Clinical and Experimental Research, 44(4), 900-918. PMID: 32293732.  May, PA, Hasken, J, Baete, A, Russo, J, Elliott, AJ, Kalberg, WO, Buckey, D, Brooks, M, Ortega, MA, Hedrick, DM, Tabachnick, B, Abdul-Rahman, O, Adam, MP, Jewett, T, Robinson, LK, Man- ning, M, & Hoyme, HE. (2020). Fetal alcohol spectrum disorders in a midwestern city: child characteristics, maternal risk traits, and prevalence. Alcoholism: Clinical and Experimental Research, 44(4), 919-938. PMID: 32293735.  Ye, P, Angal, J, Tobacco, D, Willman, A, Friedrich, C, Nelson, M, Burd, L, & Elliott, AJ. (2020). Risk factors for prenatal drinking in the Northern Plains: differences between American Indian and Caucasian mothers. American Journal of Preventive Medicine. 58(4), e113-e121. PMID: 32061456.  Elliott, AJ*, Kinney, HC*, Haynes, RL, Dempers, JD, Wright, C, Fifer, WP, Angal, J, Boyd, TK, Burd, L, Burger, E, Folkerth, RD, Groenewald, C, Hankins, G, Hereld, D, Holm, IA, Hoffman, HJ, Myers, MM, Nelsen, LL, Odendaal, HJ, Petersen, J, Randall, BB, Roberts, DJ, Robinson, F, Schubert, P, Sens, MA, Sullivan, LM, Tripp, T, Van Eerden, P, Waddee, S, Willinger, M, Saharie, D, Dukes, KA for the PASS Network. Concurrent prenatal drinking and smoking increases the risk for SIDS: Report of the Safe Passage Study (* Elliott & Kinney co-primary authors). (2020). Lancet EClinicalMedicine, 19, 100247. PMID: 32140668.  Goldstein, RD, Petty, CR, Morris, SE, Human, M, Odendaal, H, Elliott, AJ, Tobacco, D, Angal, J, Brink, L, Prigerson, HG, and the PASS Network. (2020). Transitional objects of grief. Compre- hensive Psychiatry. Available online 11 January 2020, https://doi.org/10.1016/j.comppsych.2020.152161. PMID 31978784. Grants Awarded  Title: South Dakota Pediatric Clinical Trials Network (SoDakPCTN) UG1OD030019 Source: NIH/Office of the Director Start & End Dates: 09/01/2020 – 08/31/2025 Funding: $1,904,664 Multi-P.I.: Amy Elliott , Ph.D. & Katherine Wang, MD Project Statement: The purpose of the South Dakota Pediatric Clinical Trials Network (So- DakPCTN) is to leverage the enthusiasm and growth in pediatric research over the last decade to build regional capacity and skills in clinical trials.  Title:Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort – Phase II (UH3 OD023279) Source: NIH/Office of the Director PI: Amy J. Elliott, Ph.D. Project Statement: The overall goal of this proposal is to leverage the extant Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth Network Safe Passage Study (PASS) cohort to study associations between prenatal environmental exposures on neurodevelopmental and asthma outcomes in a highly vulnerable yet understudied population.  UH3 Phase Start & End Dates: 9/01/2018 – 8/31/2023 Amount Funding: $17,430,034  Supplement – Reentry into Biomedical and Behavioral Research Careers (Sania – supplement PI)

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3UH3OD023279-05S1 Funding: $80,313  Supplement – Ethics (Angal – supplement PI) 3UH3OD023279-06S2 Funding: $290,000  Title: 2/5 The cumulative risk of substance exposure and early life adversity of child health development and outcomes (R34 DA050288) Agency: NIH/National Institute for Drug Abuse (NIDA) & Eunice Kennedy Shriver National Insti- tute for Child Development (NICHD) Project Period: 09/30/2019 – 3/31/2021 Funding: $503,589 P.I.: Amy J. Elliott, Ph.D. Project Statement: This is an 18 month planning period grant to formulate the larger hBCD 10- year study. Our proposal brings together a unique combination of experts in child development and adversity, pediatric neuroimaging, medicine, biostatistics, and public health in strategically located heavily impacted areas to determine the extent to which: 1. Brain growth is disrupted by fetal substance and related pre and post-natal exposures; and 2. Disrupted patterns of brain growth are causally related to later cognitive and behavioral outcomes.  Supplement – Maternal Mortality supplement (Lucchini – supplement PI) 3R34DA050288-01S2 Funding: $193,812 Presentations Oral  Morales S, Bowers, ME, Leach S, Buzzell GA, Debnat R, Friedrich C, Andrew R, Thomes T, Fifer WP, Elliott A, & Fox NA. Lessons learned from measuring children’s neurodevelopment in a large and representative sample. (2020) Symposium presentation at the International Society of Psychoneuroendocrinology Society (ISPNE) annual meeting.  Elliott, AJ. (March 2020). Child health outcomes of concurrent prenatal exposure to alcohol and other substances. Invited presentation 2020 Public Meeting of the Interagency Coordinating Committee on Fetal Alcohol Spectrum Disorders (ICCFASD). Bethesda, MD.  Mathew, L, Snyder, NW, Lyall, K, Lee, BK, Volk, H, Fallin, MD, Croen, LA, Hertz-Picciotto, I, Newschaffer, CJ, & Elliott, AJ. (2020). Association of prenatal phthalate exposure quantified in meconium from the Early Autism Risk Longitudinal Investigation (EARLI) and Safe Passage (PASS) study with cognition at 12- months. Submitted for presentation to ISEE annual conference.  Elliott, AJ (2020). Community Based Pediatric Research: Bringing Cutting Edge Research to the Prairie. Invited presentation at the Region 6 Academic Pediatric Association annual meeting. Wichita, KS. Role of early childhood asthma in obesity development: A nationwide U.S. multi- cohort study. Presentation to ATS annual conference.  Elliott, AJ. (Jan. 2020). Bringing cutting edge research to the prairie. Invited presentation at the 35th Annual Winter Conference in Developmental Psychobiology. Cartagena, Colombia.  Morales, S, Bowers, M, Leach, S, Buzzell, G, Elliott, A, Fifer, B & Fox, N. (Oct. 2019). Electro- physiological correlates of inhibitory control in young children. Poster presentation at Interna- tional Society for Developmental Psychobiology, Chicago, IL.  Hoyme, HE, Elliott, AJ, & Amdal-Rahman, O. (December, 2019). Fetal Alcohol Spectrum Disor- ders diagnostic workshop. Invited presentation to the Center for Disabilities, University of South Dakota School of Medicine, Sioux Falls, SD. Service  Avera Research Institute  Committee service  Member, Research Executive Committee, Avera McKennan Hospital & University Health Sys- tems. 2018 – present  Member, Diversity Health Affairs Committee, Sanford School of Medicine, University of South Dakota: 2017 - 2019

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Professional Grant reviewer  NIH COBRE, NARCH, special emphasis study sections Committee service  Member, External Advisory Committee, NIH Infant and Toddler Toolbox project: 2020 – present (nominated position)  Co-Chair, Study Design Working Group, hBCD Research Network: 2019 – present (NIH appointed position)  Co-Chair Cohort Representative, ECHO Executive Committee: 2019 – present (cohort peer nominated position)  Co-chair, Biospecimen Working Group, Environmental Influences on Child Health Outcomes (ECHO), NIH Office of the Director: 2016 – 2019 (NIH nominated position)  Patient Centered Outcomes Research Partnership (PCORP) Advisory Board, University of Washington: 2016 - present  Advisory Board Member, Healthy Native Babies Project, National Institutes of Health: 2016-present  Regional  Board Member, American Cancer Society, Midwest Division State Leadership Board: 2015 - present  Member, Center for Brain and Behavior Research, University of South Dakota: 2015 - 2020

Christine Hockett, Ph.D.

Teaching  Healthcare Profession Students (Graduate Students) Mentoring  Addison Reimer, Thesis Committee, Maters in Nutrition and Exercise Science, South Dakota State University, expected graduation May 2021 Scholarly Activity Publications  Perreault L, Hockett CW, Holmstrom H, Tolle L, Kramer ES, et al. PATHWEIGH Tool for Chronic Weight Management Built into EPIC Electronic Medical Record: Methods, Pilot Results and Fu- ture Directions. 2020. J Obes Chronic Dis 4(1): 42-48.  Anandakumar A, Praveen P, Hockett CW, Ong T, Jensen E, Isom S, D’Agostino R Jr., Hamman R, Mayer-Davis E, Wadwa P, Lawrence J, Pihoker C, Kahn M, Dabelea D, Tandon N, Mohan V. (2019) Treatment regimens and corresponding A1c levels for type 1 and type 2 diabetes: Data from SEARCH (US) and YDR (Indian) registries. Pediatr Diabetes. 2020 Mar 5. PMID: 32134536.  Hockett CW, Praveen P, Ong T, Anandakumar A, Isom S, Jensen E, D’Agostino R Jr., Hamman R, Mayer-Davis E, Lawrence J, Pihoker C, Kahn M, Mohan V, Tandon N, Dabelea D. (2019) Clinical profile at onset of diabetes in SEARCH and YDR youth: an international harmonization of youth diabetes registries. Pediatr Diabetes. 2020 Jan 17. PMID: 31953884.  Praveen P, Hockett CW, Ong T, Anandakumar A, Isom S, Jensen E, Mohan V, Dabelea D, D'Agostino Jr. R, Hamman R, Mayer-Davis E, Lawrence J, Dolan L, Kahn M, Madhu SV, Tandon N. (2019) Diabetic ketoacidosis (DKA) among patients with young-onset type 1 and type 2 diabetes: Results from SEARCH (USA) and YDR (India) registries. Pediatr Diabetes. 2020 Jan 14. PMID: 31943641.  Jensen E, Dabelea D, Praveen P, Anandakumar A, Hockett CW, Isom S, Ong T, Mohan V, D’Agostino R Jr., Kahn M, Hamman R, Wadwa P, Dolan L, Lawrence J, Madhu SV, Chhokar R, Goel K, Tandon N, Mayer-Davis E. (2019) Comparison of the incidence of diabetes in U.S. and Indian youth: An international harmonization of youth diabetes registries. Pediatr Diabetes. 2020 Mar 20. PMID: 32196874

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 Perng W, Hockett CW, Sauder KA, and Dabelea D. In utero exposure to gestational diabetes mellitus (GDM) and cardiovascular risk factors in youth: A longitudinal analysis in the EPOCH cohort. Pediatr Obes 15(5):e12611, 2020. PMID: 31920001 Grants Awarded  UG1OD030019 (Elliott, Wang), NIH Office of the Director 09/1/2020 – 08/31/2025 South Dakota Pediatric Clinical Trials Network (SoDakPCTN) The purpose of the South Dakota Pediatric Clinical Trials Network (SoDakPCTN) is to leverage the enthusiasm and growth in pediatric research over the last decade to build regional capacity and skills in clinical trials. Given the level of health disparities in our region, particularly amongst the AI populations, coupled with the remote nature of our rural communities, a mechanism for development of pediatric clinical trials research will not only grow pediatric research, it will improve health of children in South Dakota. Role: Co-Investigator, Junior Faculty  UH3OD023279 (Elliot), NIH Office of the Director 09/01/2020 – 08/31/2021 Capturing participant behavioral changes in relation to COVID-19 and how they relate to ECHO primary Outcomes: This ancillary study focuses on how COVID and its related societal changes, while necessary, may alter children’s dietary intake, physical activity, screen time and sleep in ways that accelerate the rise in obesity. Role: Co-Investigator  R34DA050288 (Elliott), NIH, National Institute for Drug Abuse 09/30/2019 – 03/31/2021 The cumulative risk of substance exposure and early life adversity of child health development and outcomes This is an 18 month planning period grant to formulate the larger hBCD 10-year study. Our proposal brings together a unique combination of experts in child development and adversity, pediatric neuroimaging, medicine, biostatistics, and public health in strategically located heavily impacted areas to determine the extent to which: 1.) brain growth is disrupted by fetal substance and related pre and post-natal exposures; and 2.) disrupted patterns of brain growth are causally related to later cognitive and behavioral outcomes. Role: Co-Investigator  P30 DK092923 (Hockett) CAIANDTR pilot and feasibility project 08/01/2019 – 07/31/2020 Spatial Clustering and Associated Determinants of Diabetes in Navajo Youth This pilot project is funded by a center grant at the Center for American Indian and Alaska Native Diabetes Translational Research (CAIANDTR), University of Colorado. The objective of the project is to identify spatial clustering of type 2 diabetes in Navajo youth from 2002-2016 and determinants of health associated with the high-risk clusters. Role: Principal Investigator, Pilot Project  R01 DK115434-01 (Dabelea/Sauder) NIDDK 09/15/2017 – 08/31/2022 Reducing risk factors for type 2 diabetes in American Indian youth: Tribal Turning Point This randomized controlled trial evaluates the effect of a behavioral intervention on diabetes risk factors in 7-10 year old American Indian children across three communities, and explores factors related to participant engagement, program implementation, and potential for sustained delivery. Role: Co-Investigator  UH33OD023279 (Elliott), NIH Office of the Director 09/01/2016 – 08/31/2023 Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Cohort The major goals of the project are to: 1) build upon current mechanisms to retain contact with PASS participants previously consented for future studies, stressing community engagement strategies to ensure long-term participation; 2) work with the ECHO consortium to develop common and site-specific protocols, documents, and procedures. PASS-ECHO brings expertise in the characterization of early life exposures, fetal to childhood physiology, asthma and lower-airway assessments, and neurodevelopmental outcomes; 3) conduct training and feasibility testing on study elements to ensure high quality data collection; and 4) work with the ECHO consortium to harmonize PASS data with other ECHO cohort sites. Role: Co-Investigator  R01 HL126578 (Buckwald) National Heart, Lung, and Blood Institute 06/01/2015 – 05/31/2021

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Diet Intervention for Hypertension: Adaptation and Dissemination to Native Communities This multi-site randomized controlled trails evaluates the effect of a behavioral intervention on reducing hypertension in Native American adults using a culturally-tailored curriculum around the DASH diet, a low-salt, high potassium, heart-healthy diet. Role: Site Principal Investigator Oral Presentations  Hockett CW, Invited Speaker, Fetal Programming and its role in obesity and diabetes in youth, Avera Health, Department of Pediatrics Grand Round, Oct. 9th 2020 Hockett CW, Invited Panelist and Speaker, COVID-19 Projections in South Dakota, Project ECHO, University of South Dakota, April 16th 2020 Clinical Service New Clinics/Programs/Outreach  Peds 5-2-1-0 Initiative – An initiative with the pediatric service line within the Avera Health system focused on providing educational material and guidance to children on the 5-2-1-0 health initiative. I am an active member of this group. Volunteer Service  Director of Community Research, Center for Pediatric and Community Research, Avera Re- search Institute, Rapid City, SD Community  United Way, Day of Caring Professional  Publications Committee, Member, Institutional Developmental Award (IDeA) States Pediatric Clinical Trails Network, Sept. 2020 – current  Co-lead, Obesity Data Harmonization Working Group, Environmental Influences on Child Health Outcomes (ECHO)

Morgan Nelson, MS

Teaching Medical Students  Hanna Leschisin - Medical student at the University of South Dakota  Healthcare Profession Students  Jennifer Lindgren - Master’s Student at the University of South Dakota. – Undergraduate Students  Jennifer Lindgren - Master’s Student at the University of South Dakota. Lecture Gues Lecture, Internal Medicine Residents. ”Interpreting Statistics in Literature, Reading beyond p- values” Mentoring Residents  Shahid M, Bleeker J, Arsalan M, Waleed M, Nelson ME, Dosch K, Atiq M. Col- orectal cancer in South Dakota: Spatial trends in relation to Socio-economic Status. Abstract accepted for poster presentation at the Virtual 2021 ASCO Gastrointestinal Cancers Symposium.  Abdallah MA, Shahid M, Abdullah AA, Ellithi M, Nelson ME, Solomon B, Bleeker JS. Clinical Util- ity of Comprehensive Genomic Profiling and Targeted Therapy in Biliary Tract Cancers - A Real- World Experience. Online poster presentation at the 2020 American Society of Clinical Oncology Annual Meeting in Chicago, IL (2020).  Ellithi M, Abdallah MA, Shahid M, Ailts I, Waligoske K, Fanta J, Bell M, Fischer M, Nelson ME, Bleeker JS. Evolution of clinical outcomes of metastatic pancreatic adenocarcinoma: a 10-year single institution retrospective study. Online poster presentation at the 2020 American Society of Clinical Oncology Annual Meeting in Chicago, IL (2020).

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Scholarly Activity Publications Published  Abdallah M, Wongjarupong N, Hassan M, Taha W, Abdalla A, Onyirioha K, Bampoh S, Nelson ME, Gilbranson M, Wiseman G, Fleming C, Andrews J, Mahipal A, Roberts L. (2020). The Effi- cacy, Safety, and Predictors of Outcomes of Transarterial Radioem- bolization for Hepatocellular Carcinoma: A Retrospective Study. Expert Review of Gastroenterology & Hepatology, 14(7), 619-629. PMID: 32490691.  Abdallah MA, Waleed M, Bell MG, Nelson ME, Sundaram V, Wong R, Singal AK. (2020). Sys- tematic Review and Meta-analysis: Liver Transplant Provides Survival Benefit Worldwide in Pa- tients with Acute on Chronic Liver Failure. Alimentary Pharmacology & Therapeutics, 52(2), 222- 232. PMID: 32490550.  Rhone K, Lindgren J, Mack LJ, Nelson ME, Spencer L, Anderson SM. (2020). Avera eCARE: Medical Student Education in Telemedicine. Telehealth and Medicine Today, 5(2), 1-9.  Xie C, Abdallah MA, Nelson ME, Bohy K, Bleeker J, Patel B, Abdullah A, Aloreidi K, Kiani R, Atiq M. (2020). Finding a needle in a haystack: EUS-FNA for solid pancreatic masses in the background of chronic pancreatitis. Annals of Gastroenterology, 33(4), 1-8. PMID: 32624664.  Shuffrey LC, Myers MM, Isler JR, Lucchini M, Sania A, Pini N, Nugent JD, Condon C, Ochoa T, Brink L, du Plessis C, Odendaal HJ, Nelson ME, Friedrich C, Angal J, Elliott AJ, Groenewald C, Burd L, Fifer WP, PASS Network. (2020). Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity: Results from the Safe Passage Study. Journal of the American Medical Association: Network Open, 3(5), e204714. PMID: 32396193.  Ye P, Angal J, Tobacco D, Willman A, Friedrich C, Nelson ME, Burd L, Elliott AJ. (2020). Risk factors for prenatal drinking in the Northern Plains: differences between American Indian and Caucasian mothers. American Journal of Preventative Medicine, 58(4), e113-e121. PMID: 32061456. Presentations Oral  Nelson ME. Human Subject Protections: The Statistical IRB Member Prospective. Presentation for Avera Oncology and Health Science Institutional Review Boards. Sioux Falls, SD.  2020 Nelson ME. Invited Alumni Speaker for the University of South Dakota, Honors Program 2020 Graduation Banquet. Cancelled due to COVID-19. Provided Facebook video instead. Ver- million, SD.  2020 Nelson ME. Role of a Biostatistician: Data and Analytics. Presentation for the Avera Acad- emy for high school students investigating health careers. Sioux Falls, SD. Volunteer Service  Scientific member – Avera Health Oncology IRB Other  Awarded University of South Dakota Honors Program 2020 Alumni Achievement Award.

Ping Ye, PhD

Teaching Lecture  PHA 738, Health Informatics, South Dakota State University  PHA 727, Professional Resources Management, South Dakota State University

Mentoring  Internal Medicine Residents, University of South Dakota School of Medicine  Claire Kittock, MD/PhD student, USD Sanford School of Medicine  Megan Sommers, Medical student, University of South Dakota School of Medicine  Michael Wallum, Medical student, University of South Dakota School of Medicine

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Scholarly Activity Publications  Ye P, Angal J, Tobacco DA, Willman AR, Friedrich CA, Nelson ME, Burd L, Elliott AJ. Prenatal drinking in the Northern Plains: differences between American Indian and Caucasian mothers. American Journal of Preventive Medicine, 58(4):e113-e121 (2020).  Waqas Ullah, Sohaib Roomi, Hafez M. Abdullah, Maryam Mukhtar, Zain Ali, Ping Ye, Donald C. Haas, Vincent M. Figueredo. Diagnostic Accuracy of Cardiac Magnetic Resonance Versus Frac- tional Flow Reserve: A Systematic Review and Meta-Analysis. Cardiol Res. 2020;11(3):145-154. doi: https://doi.org/10.14740/cr1028  Simon J. Newkirk, Lingqi Kong, Mason M. Jones, Chase E. Habben, Victoria Bishop, Ping Ye, Wenfeng An. Subfamily-specific quantification of endogenous mouse L1 retrotransposons by droplet digital PCR. Analytical Biochemistry, 20 May 2020, 113779.  Misty Jensen, Ping Ye. "Pharmacy Informatics: Technologies for the Medication Use Process and Professional Education," in Chapter 7 of Tan, J. (ed) Adaptive Health Management Infor- mation Systems: Concepts, Cases, and Practical Applications, Fourth Edition, Jones & Bartlett Learning, Burlington, MA (USA) 2020. Grants Awarded  Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage UH3 OD023279 Source: NIH/OD PI: Amy J. Elliott, Ph.D. Role: Co-Investigator  Leading the epigenetics study on the association between DNA methylation and children asthma Start & End Dates: 9/01/2018 – 8/31/2023 Submitted  The effect of social environment on maternal epigenetics and birth outcomes Source: NIH R01 Role: Principal Investigator Presentations Oral  Risk factors for preterm birth in the Northern Plains. Department of Allied and Population Health. South Dakota State University, Brookings, SD.  Survival analysis. Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD.  Meta-analysis of diagnostic and prognostic test accuracy. Department of Internal Medicine, San- ford School of Medicine, University of South Dakota, Sioux Falls, SD. Service  Avera Research Institute  Committee service  Chair, CPCR Data Analytics Committee  Member, Avera Oncology IRB Professional  Grant reviewer  Ad hoc reviewer, NIH ECHO Opportunities and Infrastructure Fund (OIF) Cycle 3 applications  Standing member, NIH NICHD Reproduction, Andrology and Gynecology study section (review R01, R03, R13, K99/R00, K08, K23 grant applications)  Society position  Co-chair, Awards Committee, Society for Mathematical Biology  Secretary, Society for Mathematical Biology  Committee service  Co-chair, Biospecimens Evaluation Committee, Environmental Influences on Child Health Out- comes, sponsored by NIH DO.  Conference organizer

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 Scientific Committee Member, eSMB2020, the 2020 Society for Mathematical Biology Annual Meeting online  Scientific Committee Member, the 2020 Society for Mathematical Biology Annual meeting joint with the European Society for Mathematical and Theoretical Biology, Heidelberg.  Manuscript/Conference review  Genomics  The 2020 Society for Mathematical Biology Annual meeting joint with the European Society for Mathematical and Theoretical Biology  American Medical Informatics Association (AMIA) 2020 Annual Symposium

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Surgery Dr. Jon Ryckman, Division Chief Division Members Adam Gorra, MD, FACS, Scott Keckler, MD, FACS, Jenifer Reitsma, CNP, Sarah Dorr, CNP

Teaching Medical Students Actively involved in medical student teaching including sub-internships and clinical rotations in surgery.

Healthcare Profession Students Our nurse practitioners consistently accept students to be part of the service.

Undergraduate Students Pre-med student that rotates frequently on our service for observation and research assistance.

Residents  Full time teaching of surgical residents and pediatric residents.  Dr. Ryckman is the Associate Program Director for the USD Sanford School of Medicine General Surgery Residency Program

CME Lectures  “Pediatric surgery for the boards.” Surgery Grand Rounds. Dr. Ryckman. Oct 23, 2019  “Advocacy and Research in Pediatric Trauma.” Pediatric Trauma Symposium. Dr. Ryckman. Oct 7, 2020  “Pediatric Surgical Emergencies.” Surgery Grand Round. Dr. Keckler. Aug 12, 2020 Programs Dr. Gorra led the Pediatric Trauma symposium on October 7, 2020

Scholarly Activity Publications Dr. Gorra  Acquired Urethrovaginal Fistula and Urethral Atresia in a Patient with a Sacrococcygeal Tera- toma. Journal of Pediatric Surgery 54(2019): 612-615 Dr. Reitsma  Reitsma, J. & Schumacher, B. (2018). Nursing Assessment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in the Neonate. Advances of Neonatal Care; 18(1); pp.7-13  Reitsma, J. (2019). Neonatal Surgical Conditions I. Webinar Presentations Published on the American Pediatric Surgical Nurses Association (APSNA) website.  Reitsma, J. (2019). Neonatal Surgical Conditions II. Webinar Presentations Published on the American Pediatric Surgical Nurses Association (APSNA) website. Dr. Ryckman  Stricter Booster Seat Legislation Correlates With Decreased Fatality In Children Ages 4-10 Years Involved In Motor Vehicle Collisions. Accepted for presentation at Pediatric Trauma Soci- ety Annual Meeting, November 2020

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Clinical Service New Clinics/Programs/Outreach  Dr. Keckler joined the team in September 2019. He is a board certified pediatric surgeon with over 7 years of experience after fellowship. He has a background of excellence in all pediatric surgical diseases, but especially critical care and Hirschsprung’s disease.  Dr. Gorra is the Medical Director of the Pediatric Trauma Program.  The Pediatric Trauma program received re-verification by the American Board of Surgery as a Level 2 Pediatric Trauma program. Innovative Clinical Services Projects:  Nuss Procedure formalized pathway including standard pain control protocol  Gastroschisis feeding guideline for the neonate  Pediatric appendicitis pathway for ER workup of appendicitis  Certified pediatric wound/ostomy service  Pediatric concussion clinic  Non-operative and operative treatment for pectus excavatum

Volunteer Service Hospital/Clinic Dr. Ryckman is the Chief of Staff, Surgery, for Sanford Health, South Region Professional Dr. Ryckman is the medical director of South Dakota EMS-C

Other Awards Sarah Dorr, MSN, APRN-CNP, CPNP-PC Rising Star Award recipient, Sanford Health APP Recognition Event, October, 2019

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CONTINUING MEDICAL EDUCATION (CME) PEDIATRICS GRAND ROUNDS

7/4/2019 Cancelled for 4th of July Holiday 7/18/2019 Dr. Shalome Dsouza Stroke in a Pediatric Hospital: What Now? 7/25/2019 Dr. James Jaggers Regenerative Therapy in Pediatric Cardiac Disease 8/1/2019 No Pediatric Grand Rounds 8/15/2019 No Pediatric Grand Rounds 8/22/2019 No Pediatric Grand Rounds Safeguarding the future: Pediatric Antimicrobial Stew- 8/29/2019 Dr. Fernando Bula-Rudas ardship Programs 9/5/2019 Dr. Eric Trumble Pediatric Neurotrauma 9/19/2019 Dr. Jerome Freeman Kindness and the Medical School 9/26/2019 Dr. Shawna Young - Resident Resiliency in the Face of Adversity 10/3/2019 Dr. Aimee Koenig - Resident Impact of Media Use on Children and Youth 10/17/2019 Dr. Mark Beard, MD, MHA The Future Medical Educator 10/24/2019 Dr. Sandra Peynado Pediatric ADHD Psychopharmacology Update 10/31/2019 No Pediatric Grand Rounds 11/7/2019 Dr. Michael Turner - Resident Suddenly On-Call: Flying as a Pediatrician 11/21/2019 Dr. Kurt Eeg Pediatric Urology Review 11/28/2019 Cancelled for Thanksgiving 12/5/2019 Cory Brown, MA Public Policy 101 The Times They Are a Changin’: How Childhood Has 12/19/2019 Dr. Molly Linn - Resident Changed in Recent Decades 12/26/2019 Cancelled for Holidays 1/2/2020 Cancelled for Holidays Understanding Wellness and Burnout for Residency and 1/9/2020 Dr. Sarah Jackson - Resident Beyond 1/23/2020 Dr. Pilar de la Puente The tumor microenvironment 1/30/2020 No Pediatric Grand Rounds 2/6/2020 Dr. Jared Daniel Pediatric Fractures – “when to splint, cast, or refer?” Native American Indian children and Lower Respiratory 2/20/2020 Dr. Santiago Lopez Tract Infection (LRTI) 2/27/2020 Dr. Isum Ward Care for the Child with Achondroplasia 3/5/2020 Dr. Tim Ridgway Finding Meaning and Joy in Our Work: VITALITY 3/19/20 – 6/25/20 Pediatric Grand Rounds were cancelled due to COVID-19

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2019-2020 DEPARTMENTAL AWARDS

DISTINGUISHED RESEARCHER AWARD—Dr. Kameswaran Surendran This award is given to a faculty member who has made significant contributions to the advancement of an area ofbiomedical behavioral, or medical, as evidenced by publications, national/international recognition, sustained record of competitive grant, support by intramural and extramural agencies, and other scholarly activity while at the University of South Dakota Sanford

DEDICATED TEACHER AWARD—Dr. Michelle Schimelpfenig This award is given to a faculty member who, through meritorious teaching of biomedical, behavioral, or clinical sciences, has left a mark of excellence and provided students and residents with a critical understanding of the faculty member’s discipline

OUTSTANDING RESIDENT AWARD—Drs. Molly Linn and Bryan Blacker This award is given to a graduating resident who is recognized as the pediatric resident who consistently demonstrated excellence and commitment to Pediatric Medical Education.

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EXCELLENCE IN PEDS AWARD—Dr. Tyler Sternhagen This award is given annually to a medical student who consistently demonstrates excellence in and commitment to the field of Pediatrics.