Sunday, June 24, 2018 11:00-13:00 Registration |Gosser Hörsaal ZLF Hall 13:00-13:10 Welcome and Introduction | Gosser Hörsaal ZLF Hall 13:10-17:15 Session 1: Metabolic Disruptions of Immune Cells | Gosser Hörsaal ZLF Session Chair: Sarah Dimeloe & Kavitha Scranton 13:10-14:00 Diane Mathis, Harvard Medical School, USA VAT Tregs: What they control and what controls them [Inv.01] 14:00-14:30 Christoph Hess, University Hospital Basel, Switzerland Cellular metabolic screening of patients with primary immunodeficiency - first lessons [Inv.02] 14:30-15:00 J.C. Rathmell, Vanderbilt University, USA Fueling T cell subsets in immunity and cancer [Inv.03] 15:00-15:30 Refreshment break | Gosser Hörsaal ZLF Hall 15:30-16:00 Doreen Cantrell, University of Dundee, Scotland Environment sensing signaling pathways in T cells [Inv.04] 16:00-16:30 Mark Febbraio, Garvan Institute, Australia The engineered designer cytokine IC7 protects against -induced metabolic disease [Inv.05] 16:30-16:45 G. Andrejeva*1, M.M. Wolf1, M.O. Johnson1, A.C. Rutledge2, G.S. Codreanu2, S.D. Sherrod2, J.A. McLean2, D. Gutierrez2, J.L. Norris2, J.C. Rathmell1 ,2, 1Vanderbilt University Medical Center, USA, 2Vanderbilt University, USA Metabolomics analysis reveals differential T-cell serine as a target in autoimmunity [ST.01] 16:45-17:00 S.P. Bapat*1 ,2, R.M. Evans1 ,3, Y. Zheng1, 1Salk Institute for Biological Studies, USA, 2University of California, USA, 3Howard Hughes Medical Institute, USA Obesity dysregulates PPARg-associated mitochondrial metabolism to drive immunopathology [ST.02] 17:00-18:30 Welcome Drinks Reception | Gosser Hörsaal ZLF Hall Monday, June 25, 2018 08:30-11:45 Session 2: Infection and Host Metabolic Adaptation | Gosser Hörsaal ZLF Session Chair: Luciana Berod & Marc Donath 08:30-09:00 Gwendalyn Randolph, Washington University in St. Louis, USA Interleukin 17-driven trapping of tissue lipoproteins links immunity to cardiovascular risk in murine psoriasis [Inv.06] 09:00-09:30 Jonathan Powell, Johns Hopkins , USA Old pathways provide novel insight into the role of metabolism in regulating T cell activation, differentiation and function [Inv.07] 09:30-09:45 J. Chiche*1, C. Reverso-Minietti1 ,2, R. Mhaidly1, A. Paquet1, T.J. Molina5, B. Nadel4, E. Verhoeyen1, N. Mounier2, C. Thieblemont3, J.E. Ricci1, 1Université Côte d'Azur, France, 2Centre Hospitalier Universitaire de Nice, France, 3Université Paris Diderot, France, 4Aix Marseille Univ, France, 5Hôpital Necker, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, France GAPDH expression predicts the metabolic state and the response of DLBCL patients to specific metabolic inhibitors [ST.03] 09:45-10:00 J. Ni*1 ,2, L. Bühler2, A. Stojanovic1 ,2, A. Arnold2, V. Sexl3, A. Cerwenka1 ,2, 1University of Heidelberg, Germany, 2German Cancer Research Center, Germany, 3University of Veterinary Medicine Vienna, Austria Inhibition of the metabolic checkpoint Hif1α refuels NK-cell anti-tumor activity [ST.04] 10:00-10:30 Refreshment Break | Gosser Hörsaal ZLF Hall 10:30-11:00 Agnes Lehuen, Institut Cochin, France Mait cells at the crossroad of microbiota, inflammation and diabetes [Inv.08]

Cell Symposia: Translational Immunometabolism 2018

11:00-11:30 Erika Pearce, Max Planck Institute, Germany Polyamines regulate mitochondrial respiration through eIF5A hypusination [Inv.09] 11:30-11:45 D. Dittlein2 ,3, C.J. Groß2, J. Smollich2, D. Stößel4, C. Traidl-Hoffmann1 ,2, O. Groß*1 ,2, 1University of Freiburg, Germany, 2Technical University of Munich, Germany, 3Helmholtz Center Munich, Germany, 4Universität Potsdam, Germany Imiquimod inhibits mitochondrial Complex I for K+ efflux-independent NLRP3 inflammasome activation and cancer cell growth arrest [ST.05] 11:45-12:30 Meet the Cell Press Editors | Gosser Hörsaal ZLF 12:30-13:30 Lunch | Gosser Hörsaal ZLF Hall 13:30-15:00 Poster Session 1 | Gosser Hörsaal ZLF Hall 15:00‐18:15 Session 3: Chronic Inflammation and Metabolic Disease | Gosser Hörsaal ZLF Session Chair: Elise Dalmas & Christoph Hess 15:00-15:15 J.D. Schertzer, McMaster University, Canada Statins impair glycolysis and promote inflammasome-dependent metabolic and myopathic side effects, independent of cholesterol [ST.06] 15:15-15:30 E.L. Mills*1 ,2, D.G. Ryan1, H.A. Prag5, D. Dikovskaya6, E.T. Chouchani2, C. Frezza5, A.T. Dinkova-Kostova6 ,10, R.C. Hartley9, M.P. Murphy5, L.A. O'Neill1, 1Trinity College Dublin, Ireland, 2Dana_Farber Cancer Institute, USA, 3Harvard Medical School, USA, 4GlaxoSmithKline, UK, 5University of Cambridge, UK, 6University of Dundee, UK, 7University of Oxford, UK, 8Cellzome, Germany, 9University of Glasgow, UK, 10Johns Hopkins University, USA The opposing roles of succinate and itaconate in inflammation [ST.07] 15:30-16:00 Marc Donath, University Hospital Basel, Switzerland Inflammation in : From to treatment with IL-1 Antagonists [Inv.10] 16:00-16:30 Claudia Kemper, NIH NHLBI, USA A force from within: Unexpected roles for complement in basic metabolic/cellular processes [Inv.11] 16:30-17:00 Refreshment break | Gosser Hörsaal ZLF Hall 17:00-17:30 Lydia Lynch, Trinity College, Ireland Diet and immunity; the interdependence of systemic and cellular immunometabolism [Inv.12] 17:30-18:00 Gokhan Hotamisligil, Harvard T.H. Chan School of Public Health, USA The emerging immunometabolic of the endoplasmic reticulum [Inv.13] 18:00-18:15 J.C. Chang, S. Durinck, N. Martinez-Martin, M.Z. Chen, Z. Modrusan, A.S. Peterson, S.J. Turley, J. Sonoda*, Genentech, Inc., USA Macrophage-derived neurotrophic factor GDF15 mediates a novel neuro-immune interaction in adipose tissues [ST.08] 19:00-22:00 Meet the Speakers Dinner (ticket holders only) | Restaurant Safran Zunft Tuesday, June 26, 2018 08:30‐12:00 Session 4: Nutrient sensing and microbiome-host interactions | Gosser Hörsaal ZLF Session Chair: Dirk Brenner & Nancie MacIver 08:30-09:00 Mike Hall, Biozentrum University of Basel, Switzerland mTOR signaling in growth and metabolism [Inv.14] 09:00-09:30 Janelle Ayres, Salk Institute, USA Metabolic adaptations in host-microbe co-evolution [Inv.15] 09:30-09:45 M. Martínez-López1, S. Iborra1, R. Conde-Garrosa1, C. Danne2, D.M. Reid3, G.D. Brown3, D. Bernardo4, S. Leibundgut-Landmann5, D. Sancho*1, 1CNIC, Spain, 2Kennedy Institute of Rheumatology, UK, 3Institute of Medical Sciences, UK, 4Hospital de La Princesa, Spain, 5University of Zurich, Switzerland Microbiota sensing by a Mincle-Syk axis in dendritic cells promotes intestinal immune barrier via the steady-state regulation of IL-17 and IL-22 [ST.09] 09:45-10:00 R.N. Loftus1, N. Assmann1, N. Kedia-Mehta1, K. O'Brien1, J.L. Hukelmann3, C.M. Gardiner1, K. Dettmer2, D.A. Cantrell3, L.V. Sinclair3, D.K. Finlay*1, 1Trinity College Dublin, Ireland, 2University of Regensburg,

Cell Symposia: Translational Immunometabolism 2018

Germany, 3University of Dundee, UK Amino acid-dependent cMyc signalling is essential for NK cell metabolic and anti-tumour responses [ST.10] 10:00-10:30 Refreshment Break | Gosser Hörsaal ZLF Hall 10:30-11:00 Eran Elinav, Weizmann Institute of Science, Israel Host micro biome interactions in health and disease [Inv.16] 11:00-11:30 Yasmine Belkaid, NIH NIAID, USA Preservation of immunological memory in the context of nutritional challenges [Inv.17] 11:30-11:45 C.A. Thaiss, H. Shapiro*, E. Elinav, Weizmann Institute of Science, Israel Microbiome alterations regulates post-dieting weight regain [ST.11] 11:45-12:00 X. Li, W.C. Cheng, H. Wang, T. Chao, T. Teav, J. Ivanisevic, P.C. Ho*, University of Lausanne, Switzerland Targeting glutamine metabolism in macrophages re-programs the tumor microenvironment [ST.12] 12:00-13:00 Lunch | Gosser Hörsaal ZLF Hall 13:00-14:30 Poster Session 2 | Gosser Hörsaal ZLF Hall 14:30‐17:45 Session 5: Cancer Immunity | Gosser Hörsaal ZLF Session Chair: Maxim Artyomov & Nikla Emambokus 14:30-15:00 Russell Jones, McGill University, Canada Rethinking metabolic reprogramming in T cells [Inv.18] 15:00-15:30 Laurence Zitvogel, Institut Gustave Roussy, France The composition of the gut microbiota contrast responders from non responders across cancer types amenable to PD-1 blockade [Inv.19] 15:30-15:45 K. Renner*1 ,2, H. Becker3, M. Fante1, L. Hacker1, C. Bruss1, W. Herr1, S. Lang4, J.L. Cleveland5, M. Selby6, M. Kreutz1 ,2, 1University Hospital Regensburg, Germany, 2Regensburg Center for Interventional , Germany, 3University of Kaiserslautern, Germany, 4University of Freiburg, Germany, 5Moffitt Cancer Center & Research Institute, USA, 6Bristol-Myers Squibb Redwood City, USA Reducing lactate secretion by simultaneous inhibition of MCT1 and MCT4 preserves T cell effector functions and improves checkpoint therapy [ST.13] 15:45-16:15 Refreshment Break | Gosser Hörsaal ZLF Hall 16:15-16:45 Guido Kroemer, University of Paris Descartes, France Metabolic modulation of anticancer immunosurveillance [Inv.20] 16:45-17:00 N.E. Scharping*, N. Rittenhouse, J. Filderman, A.V. Menk, A.C. Poholek, G.M. Delgoffe, University of Pittsburgh, USA Immunometabolic requirements for T cell exhaustion [ST.14] 17:00-17:45 Douglas Green, St. Jude Children's Research Hospital, USA Targeting LAP: LC3-associated phagocytosis and anti-cancer immunity [Inv.21] 17:45-17.55 Closing Remarks | Gosser Hörsaal ZLF

Cell Symposia: Translational Immunometabolism 2018