George P. Chrousos, MD

CURRICULUM VITAE

Narrative Summary p. 2-3

I. Biographical Information p. 4-6

II. Academic Honors and Awards p. 6-9

III. Membership in Professional and Scientific Organizations p. 9-9

IV. Membership in Committees - Editorial Boards - Society Boards p. 9-11

V. Publications

A. ORIGINAL ARTICLES p. 11-82

B. CHAPTERS, REVIEWS, EDITORIALS p. 82-122

C. BOOKS p. 122-124

George P. Chrousos, M.D.

CV Narrative Summary

George P. Chrousos

George P. Chrousos, MD, ScD, is Professor Emeritus of Pediatrics and Endocrinology, Director, University Research Institute for Maternal and Child Health and Precision Medicine (2017- ) and Head, Unit on Clinical and Translational Research in Endocrinology (2018-), National and Kapodistrian University of (NKUA) School of Medicine. From 2001-2018 he was Chairman of the First Department of Pediatrics at the NKUA School of Medicine, Athens, . Before returning to Greece, he was Chief of the Pediatric and Reproductive Endocrinology Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland. Since 2010, he holds the UNESCO Chair on Adolescent Health Care at the NKUA, while in 2011, he held the John Kluge Distinguished Chair in Technology and Society at the US Library of Congress.

Dr. Chrousos‟ research program has focused on the Biology and Medicine of Stress, the Physiology and Pathophysiology of the Hypothalamic-pituitary-adrenal (HPA) Axis and the molecular actions of the end-hormones of the latter, the glucocorticoids. He has worked on acute and chronic adaptations to changes in exogenous/endogenous states and conditions, which represent perhaps the most central feature of life, and on the neuroendocrine stress system, which is pivotal to implementation of these processes. He examined the key roles of stress mediators, not only in endocrine, behavioral and physical/energetic adaptations, but also as major pathogenic factors, responsible for the most important pathologies of today‟s societies, the high impact and cost chronic “chronic non-communicable disorders”, which account for the majority of morbidity and mortality plaguing contemporary societies. He has also made contributions to the understanding of the molecular actions of glucocorticoids and of their effects on the genome and epigenome, which underlie their involvement in human physiology and pathophysiology. In this context, he elucidated crucial aspects of the intensive molecular dialogue between the glucocorticoid and other major cell signalling systems and described novel diseases of the tissue sensitivity to glucocorticoids. On a practical level, Chrousos‟s studies have also contributed to the way we study, diagnose, classify and treat classic endocrine disorders of the HPA axis, including Cushing syndrome and Addison disease. In summary, Dr. Chrousos has performed biomedical research from the basic molecular/cellular level, to translational investigation, all the way to the diagnosis, treatment and management of diseases. His experimental work and the concepts he has advanced over the years have opened new horizons in our understanding of a wide spectrum of human complex disorders related to stress, beyond the classic non-communicable ones, including melancholic, atypical, seasonal and postpartum depression, the post- traumatic stress disorder, the eating disorders, the very prevalent obesity/osteosarcopenia/metabolic syndrome, the psychosomatic diseases, sleep disorders, such as insomnia and sleep apnoea, and the inflammatory/autoimmune and allergic diseases. His contributions to Biomedical Science and Medicine span and influence a broad range of medical disciplines, including Pediatrics, Internal Medicine, Psychiatry, Psychology, Rheumatology, Allergy, Sleep Medicine, Psychosomatic Medicine, Reproduction, Surgery, and Oncology.

Dr. Chrousos has authored or co-authored over 900 original scientific papers and over 600 journal reviews and book chapters. In terms of his current bibliometrics, his H-index is >193 and his work has been cited in >158,000 scientific articles (Google Scholar, July 2020); he is one of the 100 most cited scientists internationally. He is included in the ISI highly cited lists of Clinical Medicine and Biology and Biochemistry, and is the highest cited clinical endocrinologist or pediatrician in the world.

Dr. Chrousos has received numerous national and international awards and has given many named lectures in the USA, Europe, Latin America and Japan. His awards include the 1987 Richard E. Weitzman Memorial Award of the US Endocrine Society, the 1992 Superior Service Award of the U.S. Public Health Service, the 1997 Clinical Investigator Award of the US Endocrine Society, the 1997 Hans Selye Award of the Hans Selye Foundation, , Canada, the 1999 Pharmacia- Upjohn International First Prize for Excellence in Published Clinical Research of the US Endocrine Society, the 1999 Novera Herbert Spector Award of the International Society for Neuroimmunomodulation, Lugano, Switzerland, the 2000 Henning Andersen Prize, of the European Society for Pediatric Endocrinology, Brussels, Belgium, the 2002 Sir Edward Sharpey-Schafer Medal of the British Endocrine Societies, the 2004 Lifetime Achievement Award of the International Society for Psycho-Neuro-Endocrinology, Glasgow, UK, the 2007 Henning Andersen Prize of the European Society for Pediatric Endocrinology, Helsinki, Finland, and the 2008 Geoffrey Harris Prize in Neuroendocrinology of the European Society of Endocrinology, Berlin, Germany. Ηe was honored with the 2011 Aristeion Bodossaki Award, the highest distinction for accomplishment in the Sciences in Greece. In 2012, he received the Albert Struyvenberg Medal of the European Society of Clinical Investigation (ESCI). He is a distinguished visiting scientist at the Eunice Kennedy Shriver 2

George P. Chrousos, M.D.

NICHD, NIH, Bethesda MD, USA. He served as Board Member and President of the International Society of Neuroimmunomodulation, ESCI, and European Society of Pediatric Endocrinology. In 2014, he received the highest honor of the US Endocrine Society, the Fred Conrad Koch Award. In 2015, he was awarded the first George Papanicolaou Award of the University of Athens. In 2018, he delivered the Litchfield Lecture at the University of Oxford.

He is a Doctor Honoris Causa of the University of Liege, Liege, Belgium (2003), Universita Politechnica delle Marche, Ancona, Italy (2006) and University of Patras, Patras, Greece (2011). He is an Honorary Professor of the University of Warwick, Coventry, UK, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia and Xi‟an Medical University, Xi‟an, China, Democritean University, Alexandroupolis, Greece.

Dr. Chrousos was inducted as a Master of both the American College of Endocrinology and the American College of Physicians and a Fellow of the Royal College of Physicians. He is an elected member of the American Society for Clinical Research, the Association of American Physicians, the US National Academy of Medicine, and the Academia Europaea.

At the NIH, Dr. Chrousos run one of the leading pediatric endocrine training programs in the world and fostered the careers of over 60 distinguished, award-winning, world-class physician-scientists and basic scientists. Throughout his tenure, he collaborated closely with the National Institute of Mental Health (NIMH), and performed pioneering work on the psychoneuroendocrinology of psychiatric disorders. After a distinguished career in the Intramural Program of the NIH, where he made seminal original contributions and trained a generation of international leaders in Pediatric, Adult and Reproductive Endocrinology and Psychoneuroendocrinology, Dr. Chrousos returned to Greece and assumed leadership roles in Greek and European Medicine and Academia.

In Greece, Dr. Chrousos directed the oldest, largest and most prestigious Department of Pediatrics in the country and has had major impact on the way Pediatrics and Medicine are practiced. For instance, he developed new national growth curves, initiated a national campaign against childhood obesity, chaired the National Council on Breast Feeding, developed an administrative mechanism for certifying baby-friendly hospitals, started a national successful campaign for breast feeding (UNICEF Award 2011), initiated a longitudinal study of children conceived by assisted reproductive technologies and discovered significant epigenetic effects of these procedures on childhood cardiometabolic health (Academy of Athens Award 2011), established two graduate programs in “Pediatric and Nursing Research”, and in the “Science of Stress and Health Promotion”, established the first Adolescent Medicine Program in the country and helped with the founding of a new biomedical research institute (Biomedical Research Foundation of the Academy of Athens). In 2010, the prototypic Adolescent Medicine Program that he established at the NKUA was recognized as the unique UNESCO Chair in Adolescent Health Care. He served as vice-President of the Greek National Council of Research and Technology. He founded the Hellenic College of Pediatrics, the Hellenic Society of Developmental and Behavioral Pediatrics and Adolescent Medicine, The Institute of Stress Biology and Medicine, and the NGO “Health for All” for the support of vulnerable populations in Greece.

Dr. Chrousos has an encompassing global outlook. He is intimately familiar with the strengths and weaknesses of both European and US biomedical science. He has an unwavering commitment to promote and nurture the international leadership and excellence of research in Medicine and the Biomedical Sciences.

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George P. Chrousos, M.D.

I. BIOGRAPHICAL INFORMATION

NAME: George P. Chrousos, M.D.

PRESENT ADDRESS: Kyprou 2 Athens, Greece 15 452

DATE AND PLACE OF BIRTH: July 18, 1951; Patras, Greece

CITIZENSHIP: Greece, USA

DEGREES: M.D., National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece, 1975 Sc.D., National and Kapodistrian University of Athens, Athens, Greece, 1977 Doctor Honoris Causa, Liege University, Liege, Belgium, 2003 Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy 2006 Doctor Honoris Causa, University of Patras, Patras, Greece 2011

CURRENT POSITIONS: Professor Emeritus of Pediatrics and Endocrinology and Head, Unit of Clinical and Translational Research in Endocrinology (2018-), National and Kapodistrian University of Athens Medical School

Director, University Research Institute for Maternal and Child Health and Precision Medicine (2017- )

UNESCO Chair on Adolescent Health Care (2010-) National and Kapodistrian University of Athens Medical School

TransCampus Professor of Medicine, University of Dresden and King‟s College, London (2018-)

FORMER POSITIONS HELD: Senior Investigator Developmental Endocrinology Branch (1981 - 1989) National Institute of Child Health and Human Development, NIH

Chief, Pediatric Endocrinology Section Developmental Endocrinology Branch (1989 - 1999) National Institute of Child Health and Human Development, NIH

Chief, Pediatric and Reproductive Endocrinology Branch (1999-2001), National Institute of Child Health and Human Development, NIH

Senior Investigator (part-time) and Distinguished Visiting Scientist, Pediatric and Reproductive Endocrinology Branch (2002-2004) and Reproductive Biology and Medicine Branch (2005-2018), National Institute of Child Health and Human Development, NIH

Chairman, First Department of Pediatrics, and Head, Division of Endocrinology, Metabolism and Diabetes (2001-2018), National and Kapodistrian University of Athens Medical School, Athens, Greece

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George P. Chrousos, M.D.

POSTGRADUATE TRAINING 1975-1980

1. 1975-1976 Research Fellow, Laboratory of Microbiology and Immunology, National and Kapodistrian University Athens University, Athens, Greece. 2. 1975-1976 Resident, First Department of Internal Medicine, National and Kapodistrian University ofAthens, Faculty of Medicine, Athens, Greece. 3. 1976-1978 Resident, Department of Pediatrics, New York University Medical Center, New York, NY. 4. 1978-1981 Clinical Associate, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland.

CERTIFICATION AND LICENSURE

1. 1975 License to practice Medicine in Athens, Greece 2. 1975 Educational Council for Foreign Medical Graduates (ECFMG); Standard Certificate. 3. 1977 Federation of State Licensure Examination (FLEX). License to practice in Massachusetts, Maryland, Virginia and District of Columbia. 4. 1980 American Board of Pediatrics 5 1980 American Board of Pediatric Endocrinology 6. 1980 Greek Board of Pediatrics 7. 1981 Greek Board of Endocrinology

ADMINISTRATIVE DUTIES

• Director, NICHD/Georgetown University ACGME-accredited Training Program in Pediatric Endocrinology (1988-2002)

• Chairman, Medicine and Physiology Department, Foundation for the Advanced Education in the Sciences at the National Institutes of Health (1990-2002)

• Chairman, Selection Committee and General Director, Biomedical Research Foundation (IIBEAA), Academy of Athens, Athens, Greece (on sabbatical leave 2001-2002)

• Chairman, Greek Board of Pediatrics (2004-2018)

• Director, Division of Maternal and Child Health, and Member, Board of Directors, Athens University Medical School, Athens, Greece (2004-2005, 2007- 2009, 2013-2014)

• Director, Division of Endocrinology, Metabolism and Diabetes, Evgenidion Hospital, Athens University Medical School, Athens, Greece (2005- )

• Chairman, National Council on Breast Feeding, Ministry of Health, Greece (2007- )

• Senior Scientist and Director, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens (IIBEAA), Athens, Greece (2008-2014)

• Director, Graduate Program on the Science of Stress and Health Promotion, Medical School, University of Athens, Athens, Greece (2008-2014)

• Director, Graduate Program on Pediatric and Nursing Research, Medical School, University of Athens, Athens, Greece (2008-2016)

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George P. Chrousos, M.D.

• Director, A‟ Sector of Medicine, Aghia Sophia Children‟s Hospital, National Health Service (2009- 2019)

• Vice President, National Council on Research and Technology, Ministry of Education, Greece (2010- 2013), Member (2013-2016)

• Chairman, National Council on Vaccinations, Ministry of Health, Greece (2014- 2017)

• Vice President, Higher Education Council, Hellenic Authority of Higher Education, Greece (2020-

II. ACADEMIC HONORS AND AWARDS

1. 1969-1975 "Scholarship of Excellence" awarded by the State Scholarship Institution, Ministry of Education, Greek Government. 2. 1972-1975 Scholarship "A. Papadakis", Athens University, Athens, Greece. 3. 1975 M.D. Degree summa cum laude (valedictorian), Athens, University, Faculty of Medicine, Athens, Greece. 4. 1977 Doctorate Diploma, "Excellent." Athens University, Athens, Greece. 5. 1981-1983 Clinical Assistant Professor of Pediatrics 1983-1985 Clinical Associate Professor of Pediatrics 1985-Date Clinical Professor of Pediatrics, Georgetown University Medical School, Washington, D.C. 6. 1987 June The "Richard E. Weitzman Memorial Award," awarded by the U.S. Endocrine Society "for outstanding research achievements in the fields of endocrinology and metabolism". 7. 1990-Date Adjunct Professor of Physiology and Biophysics, Georgetown University Medical School, Washington, D.C. 8. 1990 Expert Testimony to 101st US Congress 9. 1991 May The "Galen Award", Hellenic American Society for the Health Sciences, Washington, D.C. 10. 1991 July Honorary Faculty, Keio University School of Medicine, , Japan 11. 1992 June Superior Service Award, U.S. Public Health Service, "for pioneering studies on the regulation of hypothalamic-pituitary-adrenal axis function, leading to new insights into the pathophysiology of adrenal diseases and novel diagnostic strategies". 12. 1993 October Honorary Faculty, Parma University, Parma, Italy 13. 1997 June The 1997 Endocrine Society Clinical Investigator Award, “for major achievements in clinical investigation”. 14. 1997 July The 1997 Hans Selye Award, Hans Selye Foundation, Montreal, Canada, “for outstanding contributions to stress research.” 15. 1999 June First Prize, 1999 Pharmacia-Upjohn International Award for Excellence in Published Clinical Research awarded by the US Endocrine Society. 16. 1999 June Professor of Pediatrics, Athens University Medical School (elected) 17. 1999 October The 1999 Novera Herbert Spector Award, International Society for Neuroimmunomodulation, Lugano, Switzerland “for significant contributions in both leadership and research in neuroimmunomodulaton.” 18. 1999 October Certificate of Commendation, American Academy of Pediatrics “for important contributions made to the mission and goals of the Academy and to the children.” 19. 2000 Sept. The 2000 Henning Andersen Prize, European Society for Pediatric Endocrinology, Brussels, Belgium 20. 2000 Nov. Mastership Award, American College of Endocrinology, “for distinction as a role model and as a contributor to the Art and Science of Endocrinology.” 21. 2001 August Certificate of Recognition, Howard Hughes Medical Institute, Teachers and Students Internship Program, Bethesda MD 22. 2001 Nov ISI Highly Cited Researcher in Clinical Medicine, ISI, Philadelphia, Pa. www.ISIhighlycited.com 23. 2001 Nov. Fellow, Japan Health Sciences Foundation, Tokyo, Japan 6

George P. Chrousos, M.D.

24. 2002 April Clinical Endocrinology Trust Professor 2002, Sir Edward Sharpey-Schafer Medal, British Endocrine Societies, for “major contributions to Endocrinology and Metabolism” 25. 2003 March Doctor Honoris Causa, University of Liege, Liege, Belgium 26. 2004 July Lifetime Achievement Award, International Society for Psycho-Neuro-Endocrinology, Glasgow, UK for “outstanding scholarship and path-breaking contributions to Psychoneuroendocrinology”. 27. 2004 Dec Distinguished Physician Award, Hellenic Medical Society of New York 28. 2005 April Mastership Award, American College of Physicians (MACP), “for significant contributions to the Art and Science of Medicine” 29. 2006 May Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy 30. 2006 June ISI Highly Cited Researcher in Biochemistry and Biology, ISI, Philadelphia, Pa. www.ISIhighlycited.com 31. 2006 Dec The 2006 Gentle Giant Award, Pituitary Network Association, Rancho Mirage, Ca. “for exceptional services above and beyond in the study of pituitary diseases” 32. 2007 April The 2007 Henning Andersen Prize, European Society for Pediatric Endocrinology, Helsinki, Finland 33. 2007 June Symposium on Cortisol Secretion Abnormalities Honoring Dr. George P. Chrousos Horm Metab Res. 2007 Jun; 39(6): 401-3. 34. 2007 Honorary Member, American Pediaric Society 35. 2008 May 2008 Geoffrey Harris Prize in Neuroendocrinology, European Society of Endocrinology, Berlin, Germany 36. 2008 May Honorary Fellow (FRCP), Royal College of Physicians, London, UK. 37. 2008 Distinguished Visiting Scientist, NICHD, NIH, Bethesda, MD, USA 38. 2010- Distinguished Visiting Professor, King Saud University, Riyadh, S. Arabia 39. 2010- UNESCO Chair on Adolescent Health Care 40. 2010 Member, Institute of Medicine, The National Academies, Washington, DC 41. 2010 Member, Academia Europaea (European Academy of Humanities, Letters and Sciences), London, UK 42. 2011-14 Distinguished Adjunct Professor, King Abdulaziz University, Jeddah, KSA 43. 2011 John Kluge Chair on Technology and Society, The Library of Congress, Washington, DC 44. 2011 2011 Aristeion Bodossaki Prize, Bodossaki Foundation, Athens, Greece 45. 2011 UNICEF “Personality of the Year” award for “major contribution in the protection of the human rights of children” by the UNICEF Greek National Committee 46. 2011 Doctor Honoris Causa, University of Patras, Patras, Greece 47. 2011 The Constantine Moiras Award, Academy of Athens, Athens, Greece 48. 2012 The 2012 Albert Struyvenberg Medal, The European Society of Clinical Investigation, Utrecht, the Netherlands “for Excellence and Leadership in Translational and Multidisciplinary Biomedical Research”. 49. 2013 Honorary Professor, University of Warwick, Coventry, UK 50. 2014 Award of Academic Excellence, Alexander Onassis Foundation Scholars, Athens 51. 2014 George Papanicolaou Award, University of Athens, Athens 52. 2014 Fred Conrad Koch Award, US Endocrine Society, Chicago USA 53. 2016 “Herald of the Hippocratic Spirit”, Society for the Dissemination of the Hippocratic Spirit, Athens, Greece 54. 2016 Honorary Professor, St. Petersburg State Pediatric Medical Univesity, St. Petersburg, Russia 55. 2017 Honorary Professor, Xi‟an Medical University, Xi‟an, China 56. 2017 Honorary President, Pediatric Society of Cyprus, Nicosia, Cyprus 57. 2018 Aristotle Gold Medal, International Society of Neurobiology and Psychoneuropharmacology, Kavala, Greece 58. 2018 Honorary Award, 2018 Healthcare Business Awards, Athens 59. 2018 Honorary Lifetime Member of the Hellenic Society for the Study of Attention Deficit Hyperactivity Disorder Syndrome, Athens 60. 2018 Professor of Medicine Emeritus, National and Kapodistrian University of Athens, Athens

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George P. Chrousos, M.D.

61. 2018 Distinguished Investigator Emeritus, National Insitute of Child Health and Human Development, Bethesda MD

62. 2019 Honorary Professor, Democritean University of Thrace 63. 2019 2019 George Kotzias Award, Hellenic Society of Physiology 64. 2019 2019 George Papanicolaou Humanitarian Award, The Pediatric Virology Group 65. 2019 Honorary Member, Italian Society of Pediatric Endocrinology and Diabetology, Milan 66. 2020 Elected Fellow, International Academy of Medical and Biological Engineering

SELECTED NAMED LECTURES

1989. Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA; 1989. Israel Macher Memorial Lecture, Albert Einstein College of Medicine, New York, NY; 1990. Christos Choremis Memorial Lecture, Hellenic Pediatric Society Annual Meeting, Thessaloniki, Greece; 1991. Ira Rosenthal Lecture in Pediatrics, University of Illinois, Chicago, IL; 1994. Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA; 1994. Millie Schembechler Memorial Conference on Adrenal Cancer, University of Michigan, Ann Arbor, MI; 1995. Mark Dodge Memorial Lecture, University of Kansas and University of Missouri at Kansas City, MO; 1996. Robert Vine Memorial Lecture, Australasian Pediatric Endocrinology Group Annual Meeting, Adelaide, Australia; 1997. Clinical Investigator Lecture, Endocrine Society, Minneapolis, MN; 1997. Hans Selye Memorial Lecture, International Congress of Stress, Budapest, Hungary; 1997. The J. Lester Gabrilove Lecture, Mount Sinai Medical School, New York, NY, 1998. The Novum Lecture, Karolinska Institute, Huddinge, Sweden, 1998. The 1998 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece. 1999. The 1999 Novera Herbert Spector Lecture, Fourth International Congress of the International Society for Neuroimmunomodulation, Lugano, Switzerland. 1999. The 1999 Novartis Lecture, Canadian Society of Endocrinology and Metabolism, Ottawa, Canada 2000. The 2000 Nicholas Zervas Distinguished Lecture in Neuroendocrinology, Harvard University Medical School, Boston, Massachusetts. 2001. The 2001 George Merikas Memorial Lecture in Medicine, The University of Athens Medical School, Athens, Greece 2001. Commencement Address, The University of Patras Medical School, Patras, Greece 2002. The 2002 Visiting Professor Lecture, British Endocrine Societies, Harrogate, England 2002 The 2002 Keith Harrison Memorial Lecture, The Endocrine Society of Australia, Adelaide, Australia 2003 The 2003 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Thessaloniki, Greece 2003. Distinguished Lecturer in Stress Biology, Children‟s Hospital of Philadelphia, University of Pennsylvania 2006. The 2006 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece 2007. Calouste Gulbenkian Foundation Lecture on “Stress, Inflammation and Well-being”, Lisbon, Portugal 2007. Megaron Plus lecture on “Genes, Brain, Stress, and Evolution”, Athens, Greece 2008. The 2008 Geoffrey Harris Lecture, European Society of Endocrinology, Berlin, Germany 2008. The 2008 Karolinska Annual Clinical Science Lecture, Stockholm, Sweden 2009. The 2009 Mortimer B. Lipsett Memorial Lecture, NIH, Bethesda, Maryland 2010. The 2010 Philip Hench Memorial Lecture, American College of Rheumatology, Atlanta, GA 2012. The 2012 Albert Struynvenberg Lecture, European Society of Clinical Investigation, Budapest, Hungary 2013. Dean‟s Lecture, Wayne State University, Detroit, Michigan, USA 2015. The 2015 Richard Kvetnansky Lecture, Institute of Experimental Endocrinology, Slovac Academy of Sciences, Bratislava, Slovakia 2016 The 2016 Robert M Blizzard Presidential Lecture, Pediatric Endocrine Society, Baltimore USA 2017. The “2017 Peter Heimann Lecture”, International Society of Surgery and International Association of

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George P. Chrousos, M.D.

Endocrine Surgeons, Basel, Switzerland 2018. “The 2018 Litchfield Lecture”, University of Oxford, Oxford, UK

III. MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC ORGANIZATIONS

American Society for Clinical Investigation (Elected 1989) Association of American Physicians (Inducted 1995) The Society for Pediatric Research (Elected 1985) The American Pediatric Society (Elected 1992) The Endocrine Society Lawson Wilkins Society for Pediatric Endocrinology The Society for Neuroscience American Federation for Clinical Research American Academy of Pediatrics (Fellow) American College of Physicians (Fellow, elected Master 2004) New York Academy of Sciences American Diabetes Association International Brain Research Organization International Society for Psychoneuroendocrinology Molecular Medicine Society (Fellow) European Society for Clinical Investigation (Elected 1995) American College of Endocrinology (Fellow; Master, Elected 2000) European Society for Pediatric Endocrinology (Corresponding Member, Elected 1997) Association of Program Directors in Endocrinology and Metabolism (1998-2002) Founding Member and Member of the Board, Association for Patient-Oriented Research (1999- 2002) Fellow, The World Innovation Foundation (2004-) Member of the Council, European Society for Clinical Investigation (2005-2008) Member, MEDINE, Medical Education in Europe (2005-2007) President, Hellenic Society of Pediatric and Adolescent Endocrinology (2006-) President, Hellenic College of Pediatrics (2006-) President, European Society for Clinical Investigation (2008-2011) European Academy of Pediatrics (2009-) Member of the Council, European Society of Pediatric Endocrinology (2012-2018), President (2017-2018) Fellow, Mind and Life Institute, New York, NY (2012-) Chairman, Scientific Council, ELEPAP, Greek Society for the Protection of Handicapped Children, Athens (2015-) Chairman, Scientific Council, “Health for All” (2016- ) President, Institute of Stress Biology and Medicine (2015- ) President, Hellenic Society of Developmental and Behavioral Pediatrics and Adolescent Medicine (2016- ) Advisory Board, European Lifestyle Medicicine Organization (2018- )

IV. MEMBERSHIP IN COMMITTEES - EDITORIAL BOARDS- SOCIETY BOARDS

Medical Record Committee (Chairman), Clinical Center, NIH (1990-1997) Pediatric Care Committee, Clinical Center, NIH Clinical Research Review Board, NICHD, NIH NIH Graduate Medical Education Committee Memorial Endowment Committee, Mortimer B. Lipsett Memorial Fund, The Endocrine Society, Bethesda, Maryland (1984) Education Committee, The Endocrine Society, Bethesda, MD (1990-1993) Editorial Board, Neuro-Endocrin-Immunology (1987-1990) Editorial Board, Journal of Clinical Endocrinology and Metabolism (1992-1995) Editorial Board, NeuroImmunoModulation (1993-2002) Fogarty International Scholars Advisory Panel (1994-2000) Editorial Board, Hellenic Medical Journal (1995-present) 9

George P. Chrousos, M.D.

Consultant, Task Force on SES and Health (1995) and Mind-Body Network (1997, 2001), John and Catherine McArthur Foundation Editorial Board, Endocrinology and Metabolism (1995-1998) Scientific Advisory Board, Institute for Hormone and Fertility Research, University of Hamburg, Germany (1995- 2005) Editorial Board, Stress (1995-present) Board of Directors, Second World Congress on Stress, Melbourne, Australia 1998 Editorial Review Panel, "Panic, Anxiety, and Stress Disorders" (C.E. Koop, Chairman), Time Life Medical (1995- 1997) Editorial Board, Molecular Psychiatry (1995-present) International Advisory Board, Arquivos Brasileiros de Endocrinologia e Metabologia (1996-present) Editorial Board, Metabolism, Clinical and Experimental (1996-2018) Editorial Board, Endocrinology (1997- 2000) Medical Advisory Board, Cushing's Support and Research Foundation, Inc. (1996-Present) Public Health/Governmental Affairs Committee (Co-Chair), Pituitary Tumor Network Association (1995-Present) Scientific Advisory Board (Co-Chair), National Adrenal Diseases Foundation, Inc. (1996-Present) Practice Guidelines Subcommittee, American Academy of Asthma, Allergy and Immunology (1997) Editorial Board, Endocrine (1997-) Committee on Classification of Corticotropin-Releasing Factor Receptors, International Union of Pharmacology (NC- IUPHAR) (1996-1998) Basic and Clinical Endocrinology Interest Group at the National Institutes of Health, Co-Chair (1997- ) Advisory Council, Klinefelter Syndrome Association of Canada (1998- ) Editorial Board, Experimental and Clinical Rheumatology (1998- ) Editorial Board, Trends in Endocrinology and Metabolism (1998-2014) Editorial Board, Iatriki (1998 - 2000) Editorial Board, Journal of Clinical Endocrinology and Metabolism (1999 - 2002) Board of Directors, International Society for the Investigation of Stress (1999- ) Editorial Board, Encyclopedia of Endocrine Disorders, Academic Press (1999- ) Editorial Board, Endocrine Practice (1999- ) Expert Consultant, Workgroup on Stress and Pre-Term Delivery, Centers for Disease Control, Atlanta, GA. (1999- ) National Aeronautics and Space Administration (NASA) Life Sciences Standing Panel, Chair (12/1/1999-11/30/2002) Editorial Board, Current Drug Targets-Immune, Endocrine Metabolic Disorders (CDT-IEMD), (2000- ) Editor-in-Chief, On-line Textbook, Pediatric Endocrinology, www.eMedicine.com Associate Editor, On-line Textbook, Endocrinology and Metabolism, www.endotext.org Special Advisory Committee (Member), Endocrine Journal, The Japan Endocrine Society (2000- ) Editorial Board, Reviews in Endocrine and Metabolic Disorders (2000- ) Board of Directors, Pituitary Network Association (2000- ) Associate Editor, Hormones, Greek Endocrine Society (2001- ) Vice President, Hellenic Society of Pediatric and Adolescent Endocrinology (2001-2006) President, International Society for NeuroImmunoModulation (2002-2005) Editorial Board, Journal of Endocrinological Investigation (2002- ) International Board, The National Institute of Stress Evaluation and Management (2002- ) Editor-in-Chief, Neuroimmunomodulation (2002- 2006) Endocrinology Consultant, Stedman‟s Medical Dictionary (2002- ) Advisory Committee on Science and Technology, Greek Orthodox Archidiocese of America (2002- ) Consensus Statement, Congenital Adrenal Hyperplasia, Lawson Wilkins Pediatric Endocrine Society and European Society for Pediatric Endocrinology, Boston (2002) Board of Counselors, The Suffering Child (2003-) (www.thesufferingchild.net) Consensus Statement on Cushing Syndrome (2002), International Symposium on Cushing Syndrome, Ancona, Italy Consensus Statement on Adrenocortical Carcinoma (2003), International Schembechler Conference on Adrenocortical Carcinoma, University of Michigan, Ann Arbor, Michigan Scientific American, Greek Edition, Scientific Advisory Board (2003- ) Scientific Advisory Board, Research Center of Intensive and Thoracic Medicine, Athens, Greece (2003-) Metabolism Network, Society for Women‟s Health, Washington, DC (2003-) 10

George P. Chrousos, M.D.

Associate Editor, The Encyclopedia of Stress (2004-) Associate Editor, Adolescent Gynecology, Reproduction and Menopause (2004- ) Editorial Board, American Journal of Medicine (2005-) Editorial Board, Gender Medicine (2005-) Adrenal Insufficiency Task Force, American College of Critical Care Medicine (2005-2007) Editorial Board, The Journal of Neuroendocrinology (2007-2012) Consensus Statement on Use of LHRH Analogs (2008), Lawson Wilkins and ESPE, Milan, Italy Consensus Statement on Use in Critical Illness-Related Cortisol Insufficiency (CIRCI) (2008), European Society Critical and Intensive Care Medicine (ESCIM) and European Society of Endocrinology (ESE), Florence, Italy Editorial Board, BMC Medicine, London, UK (2008- ) Editorial Board, Obesity Facts: The European Journal of Obesity, Basel, Switzerland (2008- ) Editorial Board, European Journal of Clinical Investigation, Ioannina, Greece (2009- ) Editorial Board, Journal of the Knowledge Economy, Springer, New York (2010- ) Editorial Board, Endocrine, Springer, New York, NY, USA Editorial Board, Translational Psychiatry, Nature Group Publications, Canberra, Australia (2011-) International Editorial Board, The American Journal of Medicine, USA (2011- ) Board of Directors, Seleni House Foundation, Inc, New York, NY, USA (2011-) Reviewing Editor, Science Signaling, American Association for the Advancement of Science, USA (2012-) Editorial Advisory Board, Nature Rev Endocrinol, Nature Publications, UK and USA (2012-) Scientific Council, Maria Tsakos Foundation-International Center for Maritime Research and Tradition, NGO, Greece (2012-2015) Member of the Council, European Society of Pediatric Endocrinology (2012-2017), President (2018-2019) Editorial Board, Steroids, Elsevier Publ. Co (2013-) Editorial Board, Journal of Compassionate Health Care, BioMed Central (2013-2019) Editorial Board, BMC Endocrine Disorders, London, UK (2019-) Editorial Board, Frontiers in Psychiatry (2020- )

VI. PUBLICATIONS

A. ORIGINAL ARTICLES

1. Musliner T, Chrousos GP, Amos H. (1977) Transport Enhancement and Reversal: Glucose and 3-0- Methylglucose. J Cell Physiology. 91: 155-168.

2. Chrousos GP, Barnes KM, Sauer MA, Loriaux DL, Cutler GB Jr. (1980) 1,9(11)-11- Deoxycortisol: An Improved Antiglucocorticoid. Endocrinology. 107: 472-477.

3. Chrousos GP, Loriaux DL, Sherins R, Cutler GB Jr. (1981) Unilateral Testicular Enlargement Resulting from Inapparent 21-Hydroxylase Deficiency. J Urol. 126: 127-128.

4. Chrousos GP, Poplack D, Kostolich M, Wiede C, Oliff A, Brown T, Bercu B. (1981) Hypothalamic- Adenohypophyseal Function in the Rhesus Monkey: A Primate Model. J Med Primatol. 10(2): 61-71.

5. Chrousos GP, Wachsclicht-Rodbard H, Adams A, Roth J, Cornblath M. (1981) Increased 125I- Insulin Specific Binding in Hypoglycemic Infants and Children. Ped Res. 15: 1345-1347.

6. Wishnick MM, Valenti Q, Doyle EF, Balian A, Genieser N, Chrousos GP. (1982) Churg-Strauss Syndrome: Development of Cardiomyopathy during Corticosteroid Treatment. Am J Dis Child. 136: 339-344.

7. Chrousos GP, Peck G, Gross E, Cutler GB Jr, Loriaux DL. (1982) Adrenal Function in Women with Idiopathic Acne. J Invest Dermatol. 78 (6): 468-471.

8. Chrousos GP, Loriaux DL, Mann D, Cutler GB Jr. (1982) Late-onset 21-hydroxylase deficiency is an allelic variant of congenital adrenal hyperplasia characterized by attenuated clinical expression and different HLA 11

George P. Chrousos, M.D.

haplotypes associates. Horm Res. 16: 193-200.

9. Chrousos GP, Brown T, Bercu B. (1982) Pharmacologic Effects of Melatonin on Hypothalamic- Adenohypophyseal Function in the Nonhuman Primate. Neuroendocrinology. 34: 343-346.

10. Chrousos GP, Renquist D, Brandon D, Barnard D, Fowler D, Loriaux DL, Lipsett MB. (1982) The Squirrel Monkey: Receptor-mediated End-organ Resistance to Progesterone? J Clin Endocrinol Metab. 55: 364-368.

11. Chrousos GP, Renquist D, Brandon D, Eil C, Pugeat M, Vigersky R, Cutler GB, Loriaux DL, Lipsett MB. (1982) Glucocorticoid Resistance and Primate Evolution: Receptor-mediated Mechanisms. Proc Natl Acad Sci. 179: 2036-2040.

12. Chrousos GP, Loriaux DL, Mann DL, Cutler GB Jr. (1982) Late-onset 21-Hydroxylase Deficiency Mimicking Polycystic Ovarian Disease: An Allelic Variant of Congenital Virilizing Adrenal Hyperplasia with a Milder Enzymatic Defect. Ann In Med. 96: 143-148.

13. Chrousos GP, Poplack D, Brown T, O'Neil D, Schwade J, Bercu B. (1982) Effects of Cranial Radiation on Hypothalamic-Anterior Pituitary Function: Abnormal Growth Hormone Secretory Dynamics. J Clin Endocrinol Metab. 54: 1135-1139.

14. Chrousos GP, Vingerhoeds A, Brandon D, Pugeat M, Eil C, Loriaux DL, Lipsett MB. (1982) Primary Cortisol Resistance in Man: A Glucocorticoid Receptor-mediated Disease. J Clin Invest. 69: 1261-1269.

15. Cassorla F, Albertson B, Chrousos GP, Booth J, Renquist D, Lipsett MB., Loriaux DL. (1982) The Mechanism of Hypercortisolemia in the Squirrel Monkey. Endocrinology. 111: 448-451.

16. Schulte HM, Chrousos GP, Oldfield R, Gold P, Cutler GB Jr, Loriaux DL. (1982) The effects of Corticotropin Releasing Factor on the Anterior Pituitary Function of Stalk-Sectioned Cynomolgus Macaques. Dose Response of Cortisol Secretion. J Clin Endocrinol Metab. 55: 810-812.

17. Schulte HM, Chrousos GP, Gold P, Philips J, Cutler GB Jr, Loriaux DL. (1982) Metabolic Clearance Rate and Plasma Half-life of Radioiodinated Corticotropin Releasing Factor in a Nonhuman Primate. J Clin Endocrinol Metab. 55: 1023-1025.

18. Chrousos GP, Sauer MA, Cutler GB Jr, Loriaux DL. (1982) 1-11-Oxa-11-deoxycortisol: A New Antiglucocorticoid with Activity in vivo. Steroids. 40: 425-431.

19. Healy DL, Hodgen GD, Schulte HM, Chrousos GP, Loriaux DL, Nicholas RH, Goldstein HL. (1983) The Thymus-adrenal Connection: Thymosin Has Corticotropin Releasing Activity in Primates. Science. 222: 1353- 1355.

20. Chrousos GP, Vingerhoeds ACM, Loriaux DL, Lipsett MB. (1983) Primary Cortisol Resistance: A Family Study. J Clin Endocrinol Metab. 56: 1243-1245.

21. Healy DL, Chrousos GP, Schulte HM, Williams RF, Baulieu EE, Gold PW, Hodgen GD. (1983) Pituitary and Adrenal Responses to the Anti-progesterone and Antiglucocorticoid Steroid RU 486 in Primates. J. Clin. Endocrinol. Metab. 57: 863-865.

22. Jacobowitz DM, Schulte HM, Chrousos GP, Loriaux DL. (1983) Localization of GRF-like Immunoreactive Neurons in the Rat Brain. Peptides. 4: 521-524.

23. Pugeat M, Rocle B, Chrousos GP, Dunn J, Lipsett MB, Nisula BC. (1984) Plasma Testosterone Transport and Primate Evolution. J. Steroid Biochem. 20: 473-478.

24. Schulte HM, Chrousos GP, Gold PW, Oldfield EH, Cutler GB Jr, Loriaux DL. (1984) Corticotropin Releasing Factor: Pharmacokinetics in Man. J. Clin. Endocrinol Metab. 58: 192-196. 12

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25. Doppman JL, Oldfield EH, Krudy AG, Chrousos GP, Schulte HM, Loriaux DL, Schaaf M. (1984) Anatomic and Technical Considerations of the Inferior Petrosal Sinus Sampling for Cushing's Disease. Radiology. 150: 999-103.

26. Almeida OFX, Schulte HM, Rittmaster RS, Chrousos GP, Loriaux DL, Merriam GR. (1984) Potency and Specificity of a Growth Releasing Factor in a Primate and in Vitro. J Clin Endocrinol Metab. 58: 309-312.

27. Chrousos GP, Brandon D, Tomita M, Renquist D, Hogan W, Loriaux DL, Lipsett MB. (1984) Estrogen and Progesterone Receptors in a Progesterone "Resistant" New World Primate. J Clin Endocrinol Metab. 58: 516- 520.

28. Chrousos GP, Schulte HM, Oldfield EH, Gold PW, Cutler GB Jr, Loriaux DL. (1984) The Corticotropin Releasing Factor Stimulation Test: An Aid in the Differential Diagnosis of Cushing's Syndrome. N Engl J Med. 310: 622-627.

29. Schulte HM, Chrousos GP, Avgerinos P, Gold PW, Oldfield EH, Cutler GB Jr, Loriaux DL. (1984) The Corticotropin Releasing Factor Stimulation Test: a Possible Aid in the Evaluation of Adrenal Insufficiency. J Clin Endocrinol Metab. 58: 1064-1067.

30. Chrousos GP, Loriaux DL, Brandon D, Hogan W, Renquist D, Johnson E, Lipsett MB. (1984) Adaptation of the Mineralocorticoid Target Tissues to the High Circulation Cortisol and Progesterone Plasma Levels in the Squirrel Monkey. Endocrinology. 115: 25-32.

31. Pugeat M, Chrousos GP, Nisula B, Loriaux DL, Brandon DD, Lipsett MB. (1984) Plasma Cortisol Transport and Primate Evolution. Endocrinology. 115: 357-361.

32. Rock J, Oldfield EH, Schulte HM, Gold PW, Kornblith PL, Loriaux DL, Chrousos GP. (1984) Corticotropin Releasing Factor Administered into the Ventricular CSF Stimulates the Pituitary-adrenal Axis. Brain Res. 323: 376-368.

33. Crawley JN, Ninan PT, Pickar D, Chrousos GP, Linnoila M, Scolnick Paul SM. (1984) Neuropharmacological Antagonism of the beta-Carboline-induced "Anxiety" Response in Rhesus Monkeys. J Neuroscience. 5: 477- 485.

34. Winterer J, Chrousos GP, Cassorla F, Loriaux DL. (1984) Acquired Refractoriness to Growth Hormone in a Patient with Isolated Growth Hormone Deficiency: Growth Hormone and Plasma Somatomedin C Response to High Dose Growth Hormone Therapy. J. Pediatrics, 104: 908-911.

35. Schuermeyer TH, Avgerinos PC, Gold PW, Cutler GB Jr, Loriaux DL, Chrousos GP. (1984) Human Corticotropin Releasing Factor in Man. Pharmacokinetic Properties and Dose-response of Plasma ACTH and Cortisol Secretion. J Clin Endocrinol. Metab. 59: 1103-1108.

36. Udelsman R, Bacher J, Galluci W, Gold PW, Morin ML, Renquist D, Loriaux DL, Chrousos GP. (1984) Hemodynamic and Endocrine Parameters in the Anesthetized Cynomolgus Monkey: A Primate Model. J Med Primatol. 13: 327-337.

37. Chrousos Antonakou G, Levine Ross J, Chrousos GP, Chu FC, Kenigsberg D, Cutler GB Jr, Loriaux DL. (1984) Ocular Findings in Turner Syndrome. A Prospective Study. Ophthalmology. 91: 926-928.

38. Tomita M, Chrousos GP, Brandon DD, Ben-Or S, Foster C, DeVougn L, Taylor SJ, Loriaux DL, Lipsett MB. (1985) Glucocorticoid Receptors in Epstein-Barr Virus-transformed Human Lymphocytes. Hormone Metabol Res. 17: 674-678.

39. Oldfield EH, Chrousos GP, Schulte HM, Rock JP, Poplack DG, Gold PW, Culter GB Jr, Kornblith PL, Loriaux DL. (1985) Active Clearance of Corticotropin-Releasing Factor from the Cerebrospinal Fluid. 13

George P. Chrousos, M.D.

Neuroendocrinology. 40: 84-87.

40. Evans MI, Chrousos GP, Mann DL, Larsen JW, McCluskey J, Green I, Loriaux DL, Overpeck J, Fletcher J, Schulman J. (1985) Attempted Prevention of Abnormal Genital Masculinization in Suspected Congenital Adrenal Hyperplasia by Adrenocortical Suppression in Utero. JAMA. 253:1015- 1020.

41. Schulte HM, Chrousos GP, Oldfield EH, Gold PW, Cutler GB. Jr, Loriaux DL. (1985) Corticotropin Releasing Factor Administration in Normal Men: Pituitary and Adrenal Responses in the Morning and Evening. Horm Res. 21: 69-74.

42. Winterer J, Chrousos GP, Loriaux DL, Cutler GB Jr. (1985) The Adrenal Suppressive Effect of Hydrocortisone in Congenital Adrenal Hyperplasia is not Affected by Varying the Dose Schedule. J Pediatrics. 106: 137-142.

43. Schuermeyer TH, Gold PW, Galluci WT, Tomai TP, Cutler GB Jr, Loriaux DL, Chrousos GP. (1985) Effects and Pharmacokinetic Properties of the rat/human Corticotropin Releasing Factor (r/h CRF) in Rhesus Monkeys. Endocrinology. 117: 300-306.

44. Schutt-Aine J, Young MA, Pescovitz O.H., Chrousos GP, Marx SJ. (1985) Hypoparathyroidism: a Possible Cause of Rickets. J Pediatrics. 106: 255-259.

45. Healy DL, Chrousos GP, Schulte HM, Gold PW, Hodgen GD. (1985) Increased ACTH, Cortisol and Arginine Vasopressin (AVP) Secretion Following the Antiglucocorticoid RU 486: Dose-response Relationships. J Clin Endocrinol Metab. 60: 1-4.

46. Oldfield EH, Chrousos GP, Schulte HM, Loriaux DL, Schaaf M, Doppman J. (1985) Preoperative Lateralization of ACTH Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Sinus Sampling. N Engl J Med. 312: 100-103.

47. Rittmaster RS, Cutler GB Jr, Sobel DO, Koppelman MCS, Loriaux DL, Chrousos GP. (1985) Morphine Inhibits the Pituitary-adrenal Response to Ovine Corticotropin Releasing Factor in Normal Subjects. JClin Endocrinol Metab. 60: 891-895.

48. Schuermeyer TH, Tsokos GC, Avgerinos PC, Loriaux DL, Balow JE, Chrousos GP. (1985) Pituitary-adrenal Responsiveness to Corticotropin-releasing Hormone in Patients Receiving Chronic, Alternate-day Glucocorticoid Therapy. J Clin Endocrinol Metab. 61: 22-27.

49. Schulte HM, Chrousos GP, Gold PW, Booth JD, Oldfield EH, Culter GB Jr, Loriaux DL. (1985) Continuous Administration of Corticotropin Releasing Hormone in Normal Volunteers: Physiological and Pathophysiological Implications. J Clin Invest. 75: 1781-1785.

50. Susman E, Nottelman F, Inoff G, Dorn L, Loriaux DL. Cutler GB Jr, Chrousos GP. (1985) The Relation of Hormonal Level and Physical Development and Social-emotional Behavior in Young Adolescents. J Youth and Adolescence. 14: 245-264.

51. Rose S, Schulte HM, Rauch A, White B, Hill S, Chandra R, Randolf J, Loriaux DL, Chrousos GP. (1985) Testicular Dysgenesis and Mixed Gonadal Dysgenesis: Biochemical Characterization and Management of a Typical Case. J Ped Endocrinol. 1: 123-128.

52. Berrettini HW, Nurnberger J, Gold PW, Chretien M, Chrousos GP, Chan JSD, Goldin LR, Gerson E. (1985) Neuropeptides in the Human Cerebrospinal Fluid. Life Sciences. 37: 1265-1270.

53. Udelsman R, Harwood J, Millan M, Chrousos GP, Catt KJ, Aguilera G. (1985) Functional Receptors for Corticotropin Releasing Factor in the Primate Peripheral Sympathetic System. Nature 319: 147-150.

54. Berrettini WH, Nurnberger JI, Chan JS, Chrousos GP, Gaspar L, Gold PW, Seidah NG, Simmons-Alling S, 14

George P. Chrousos, M.D.

Goldin LR, Chretien M, Gershon ES. (1985) Proopiomelanocortin-related Peptides in Cerebrospinal Fluid: A Study of Manic Depressive Disorder. Psychiatry Res. 16: 287-302.

55. Nieman LK, Chrousos GP, Kellner C, Spitz I, Nisula B, Cutler GB Jr, Merriam GR, Bardin CW, Loriaux DL. (1985) Successful Treatment of Cushing's Syndrome with the Glucocorticoid Antagonist RU 486. J. Clin. Endocrinol. Metab. 61: 536-540.

56. Gold P.W, Loriaux DL, Roy A, Kling MA, Calabrese JR, Kellner CH, Nieman LK, Post RM, Pickar D, Gallucci W, Avgerinos P, Paul S, Oldfield EH, Cutler GB. Jr, Chrousos GP. (1986) Responses to Corticotropin Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease: Pathophysiologic and Diagnostic Implications. N Engl J Med. 314: 1329-35.

57. Rose SR, Chrousos GP, Cornblath M, Sidbury J. (1986) Oral Starch in the Management of Post- operative Nesidioblastosis. J Pediatrics. 108: 97-100.

58. Tomita M, Brandon D, Chrousos GP, Vingerhoeds ACM, Foster CM, Loriaux DL, Lipsett MB. (1986) Characterization of Glucocorticoid Receptors from Epstein-Barr Virus-transformed Lymphocytes from Glucocorticoid Resistant Patients and a New World Primate. J Clin Endocrinol Metab. 62: 1145-1154.

59. Weiss SRB, Post RM, Gold PW, Chrousos GP, Sullivan TL, Walker D, Pert A. (1986) CRF- induced Seizures and Behavior: Interaction with Amygdala Kindling. Brain Res. 372: 345-351.

60. Levine Ross J, Schulte HM, Gallucci WT, Cutler GB Jr, Loriaux DL, Chrousos GP. (1986) Ovine Corticotropin Releasing Hormone Stimulation Test in Normal Children. J Clin Endocrinol Metab. 62: 390- 392.

61. Schiebinger R, Chrousos GP, Cutler GB, Loriaux DL. (1986) The Effect of Serum Prolactin on Plasma Adrenal Androgens and the Production and Metabolic Clearance Rate of Dehydroepiandrosterone Sulfate in Normal and Hyperprolactinemic Subjects. J Clin Endocrinol Metab. 62: 202-209.

62. Gold PW, Gwirtzman H, Avgerinos P, Nieman LK, Gallucci WT, Kaye W, Jimerson D, Ebert M, Rittmaster R, Loriaux DL, Chrousos GP. (1986) Abnormal Hypothalamic-pituitary-Adrenal Function in Anorexia Nervosa: Pathophysiologic Mechanisms in Underweight and Weight-corrected Patients. N Engl J Med. 314: 1335-42.

63. Avgerinos PC, Schuermeyer T, Gold PW, Loriaux DL, Cutler GB Jr, Chrousos GP. (1986) Pulsatile Administration of Human Corticotropin Releasing Hormone in Patients with Secondary Adrenal Insufficiency: Restoration of the Normal Cortisol Secretory Pattern. J Clin Endocrinol Metab. 62: 816-821.

64. Rosner W, Pugeat M., Chrousos GP, Khan MS. (1986) Steroid Binding Proteins in Primate Plasma. Endocrinology. 118: 513-517.

65. Pavlov EP, Harman MS, Chrousos GP, Loriaux DL, Blackman MR. (1986) Responses of Plasma Adrenocorticotropin (ACTH), Cortisol, and Dehydroepiandrosterone to Ovine Corticotropin Releasing Hormone in Healthy Aging Men. J Clin Endocrinol Metab. 62: 767-772.

66. Oldfield EH, Schulte HM, Chrousos GP, Gold PW, Benker G, Peterson RE, Cutler GB Jr, Loriaux DL. (1986) Corticotropin Releasing Factor Stimulates ACTH Secretion in Nelson's Syndrome. J Clin Endocrinol Metab. 62: 1020-1026.

67. Udelsman R, Gallucci WT, Ramp J, Goldstein DS, Lipford R, Norton JA, Loriaux DL, Chrousos GP. (1986) Adaptation during Surgical Stress: A Reevaluation of the Role of Glucocorticoids. J Clin Invest. 77: 1377- 1381.

68. Roy-Byrne PP, Uhde TW, Post RM, Gallucci W, Chrousos GP, Gold PW. (1986) The CRH Stimulation Test in Patients with Panic Disorder. Am J Psychiatry, 143: 396-399.

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69. Roy A, Gold PW, Pickar D, Wolkowitz OM, Chrousos GP, Paul S.M. (1986) Pre- and Post- dexamethasone Plasma ACTH Levels in Depressed Patients and Normal Controls. J Affective Dis. 10: 95-99.

70. Udelsman R, Bacher J, Gallucci PW, Gold PW, Renquist D, Loriaux DL, Chrousos GP. (1986) Hemodynamic Effects of Human Corticotropin-releasing Factor (hCRF) in a Nonhuman Primate. Peptides. 7: 465-471.

71. Munabi A, Feuillan P, Staton R, Rodbard D, Chrousos GP, Anderson RE, Strober MD, Loriaux DL, Cutler GB Jr. (1986) Adrenal Steroid Responses to Continuous Intravenous ACTH Infusion Compared to Bolus Injection. J Clin Endocrinol Metab. 63: 1036-1040.

72. Nieman LK, Chrousos GP, Oldfield EH, Avgerinos PC, Cutler GB Jr, Loriaux DL. (1986) The Ovine CRH Stimulation Test and the Dexamethasone Suppression Test in the Differential Diagnosis of Cushing's Syndrome. Ann Int Med. 105: 862-867.

73. Roy A, Pickar D, Doran A, Wolkowitz O, Gallucci W, Chrousos GP, Gold PW. (1986) Normal ACTH and cortisol Responses to Corticotropin Releasing Hormone in Schizophrenia. Am J Psychiatry 143: 1393-1397.

74. Saris SC, Patronas NJ, Doppman JL, Loriaux DL, Cutler GB Jr, Nieman LK, Chrousos GP, Oldfield E. (1986) Pituitary CT Scanning in Cushing's Syndrome. Radiology. 162: 775-777.

75. Doppman JL, Oldfield EH, Chrousos GP, Nieman LK, Udelsman R, Cutler GB Jr, Loriaux DL. (1986) Rebound Thymic Hyperplasia Following Treatment of Cushing's Syndrome. Am J Radiology. 147: 1145- 1147.

76. Feuillan P, Poth M, Reilly W, Bright G, Loriaux DL, Chrousos GP. (1986) Ketokonazole Treatment of Type Autoimmune Polyglandular Syndrome: Effects on Pituitary-adrenal Axis. J Pediatrics. 109: 363-366.

77. Nottelman ED, Susman EJ, Dorn LD, Inoff GE, Loriaux DL, Cutler GB, Chrousos GP. (1987) Developmental Processes in Early Adolescence: Relations among Chronological Age, Pubertal Stage, Height, Weight, and Serum Levels of Gonadotropins, Sex Steroids and Adrenal Androgens. J Adol Health Care. 8: 35-48.

78. Susman E, Inoff G, Nottelman E, Dorn L, Loriaux DL, Chrousos GP. (1987) Hormones, Emotional Disposition and Aggression Attributes in Early Adolescents. Child Development. 58: 1114-1134.

79. Rittmaster RS, Cutler GB Jr, Brandon D, Gold PW, Loriaux DL, Chrousos GP. (1987) The Effects of Endogenous Vasopressin on ACTH and Cortisol Secretion in Man. J. Clin. Endocrinol. Metab. 64: 371-376.

80. Laue L, Hoeg JM, Barnes K, Loriaux DL, Chrousos GP. (1987) The Effect of Mevinolin on Steroidogenesis in Patients with Defects in the LDL Receptor Pathway. J Clin Endocrinol Metab. 64: 531-535.

81. Kaye WH, Gwirtsman HE, George DT, Ebert M, Jimerson D, Tomai T, Chrousos GP, Gold PW. (1987) Elevated Cerebro-spinal Fluid Levels of Immunoreactive Corticotropin Releasing Hormone in Anorexia Nervosa: Relation to State of Nutrition, Adrenal Function and Intensity of Depression. J Clin Endocrinol Metab. 64: 203-208.

82. Nieman LK, Choate T, Chrousos GP, Healy D, Spitz I, Merriam GR, Bardin CW, Loriaux DL. (1987) Progesterone Antagonist RU 486: A Potential New Contraceptive Agent. N Engl J Med. 316: 187-191.

83. Nottelman ED, Susman EJ, Dorn LD, Inoff EG, Loriaux DL, Cutler GB, Chrousos GP. (1987) Developmental Processes in American Early Adolescents: Relations Between Adolescent Adjustment and Chronological Age, Pubertal Stage and Puberty-related Hormone Levels. J Pediatrics. 110: 473-480.

84. Udelsman R, Norton J, Jelenich S, Goldstein D, Linehan WM, Loriaux DL, Chrousos GP. (1987) Responses of the Hypothalamic-pituitary-adrenal and Renin-angiotensin Axis and the sympathetic System during Controlled Surgical and Anesthesia Stress. J Clin Endocrinol Metab. 64: 986-994.

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85. Feuillan P, Stein CA, LaRocca R, Lipford N, Raffeld M, Renquist D, Meyers CE, Chrousos GP. (1987) Effects of Suramin on the Function and Structure of the Adrenal Cortex in the Cynomolgus Monkey. J Clin Endocrinol Metab. 65: 153-158.

86. Kawai S, Nieman LK, Brandon DD, Udelsman R, Loriaux DL, Chrousos GP. (1987) Pharmacokinetic Properties of the Antiglucocorticoid and Antiprogesterone Steroid of RU 486 in Man. J Exp Pharmacol Ther. 241: 401-406.

87. Luger A, Deuster P, Kyle SB, Gallucci WT, Montgomery LC, Gold PW, Loriaux DL, Chrousos GP. (1987) Acute Hypothalamic-pituitary-adrenal Responses to the Stress of Treadmill Exercise: Physiologic Adaptations to Physical Training. N Engl J Med. 316: 1309-1315.

88. Doppman JL, Loughlin T, Miller DL, Pass VJ, Chrousos GP, Cutler GB Jr, Oldfield EH, Loriaux DL. (1987) Identification of ACTH Producing Intrathoracic Tumors by Measuring ACTH Levels on Aspirated Specimens. Radiology. 163: 501-503.

89. Risin Counts D, Hirsch Pescovitz O, Barnes KM, Chrousos GP, Sherins RJ, Comite F, Loriaux DL, Cutler GB. (1987) Dissociation of Adrenarche and Gonadarche in Precocious Puberty and in Hypogonadotropic Hypogonadism. J Clin Endocrino. Metab. 64: 1174-1178.

90. Udelsman R, Goldstein D, Loriaux DL, Chrousos GP. (1987) Catecholamine-glucocorticoid Interactions during Surgical Stress. J Sur Res. 43: 539-545.

91. May C, Rapoport SJ, Cutler NR, Chrousos GP, Tomai TP, Gold PW. (1987) CSF Concentrations of Corticotropin Releasing Hormone and Corticotropin Are Reduced in Patients with Alzheimer's Disease. Neurology. 37: 535-538.

92. Roy A, Pickar D, Linnoila M, Chrousos GP, Gold PW. (1987) Cerebrospinal Fluid Corticotropin Releasing Hormone in Depression: Relationship to Noradrenergic Function. Psychiatry Res. 20: 229-237.

93. Avgerinos PC, Cutler GB Jr, Tsokos GC, Gold PW, Feuillan P, Gallucci WT, Pillemer SR, Loriaux DL, Chrousos GP. (1987) Dissociation between Cortisol and Adrenal Androgen Secretion in Patients Receiving Alternate Day Prednisone Therapy. J Clin Endocrinol Metab. 65: 24-29.

94. Roy A, Pickar D, Paul S, Doran A, Chrousos GP, Gold PW. (1987) CSF Corticotropin Releasing Hormone in Depressed Patients and Normal Control Subjects. Am J Psychiatry. 114: 641-645.

95. Luger A, Calogero A, Kalogeras K, Gallucci W, Gold PW, Loriaux DL, Chrousos GP. (1987) Interaction of Epidermal Growth Factor with the Hypothalamic-pituitary Adrenal Axis: Potential Physiologic Relevance. J Clin Endocrinol Metab. 66: 334-337.

96. Laue L, Chrousos GP, Loriaux DL, Nieman LK, Munson P, Schaison G. (1987) RU 486 Suppresses the Plasma ACTH Response to Ovine Corticotropin-releasing Hormone. J Clin Endocrinol Metab. 66: 290-293.

97. Grino M, Chrousos GP, Margioris A. (1987) The Corticotropin Releasing Factor Gene is Expressed in the Human Term Placenta. Biol Bioph Res. Com 148: 1208-1214.

98. Doppman JL, Miller DL, Dwyer AJ, Loughlin T, Nieman L, Cutler GB, Chrousos GP, Oldfield E, Loriaux DL. (1987) Macronodular Adrenal Hyperplasia in Cushing's Disease. Radiology. 166: 347-352.

99. Avgerinos PC, Chrousos GP, Nieman LK, Oldfield EH, Loriaux DL, Cutler GB. (1987) The Corticotropin Releasing Hormone Test in the Postoperative Evaluation of Patients with Cushing's Syndrome. J Clin Endocrinol Metab. 65: 906-913.

100. Balis FM, Lester CM, Chrousos GP, Heideman RL, Poplack DG. (1987) Differences in Cerebrospinal Fluid Penetration of Corticosteroids: Possible Relationship to Prevention of Meningeal Leukemia. J Clin Oncol. 5: 17

George P. Chrousos, M.D.

202-207.

101. Berrettini WH, Nurnberger JI Jr, Zerbe RL, Gold PW, Chrousos GP, Tomai T. (1987) CSF Neuropeptides in Euthymic Bipolar Patients and Controls. Br J Psychiatry. 150:208-212.

102. Roy A, Gallucci W, Linnoila M, Chrousos GP, Gold PW. (1988) The CRH Stimulation Test in Bereaved Subjects with and without Accompanying Depression. Psych Res. 25:145-156.

103. Albertson B, Brandon DD, Chrousos GP, Loriaux DL. (1988) Adrenal 11-Hydroxylase Activity in a Hypercortisolemic New World Primate: Adaptive Intra-adrenal Changes. Steroids. 49: 497-505.

104. Inoff-Germain G, Snyder Arnold G, Nottelmann ED, Susman EJ, Cutler GB Jr, Chrousos GP. (1988) Relations between Hormone Levels and Observational Measures of Aggressive Behavior of Young Adolescents in Family Interactions. Dev Psychol. 24: 129-139.

105. Laue L, Hoeg J, Barnes K, Levine Ross J, Loriaux DL, Chrousos GP. (1988) Abnormal Growth Hormone Secretory Dynamics in Children with Familial Hypercholesterolemia. Hormone Res. 938:1-6.

106. Calogero AE, Bernardini R, Gallucci WT, Saoutis C, Gold PW, Chrousos GP. (1988) Cholinergic Stimulation of Rat Hypothalamic Corticotropin Releasing Hormone in Vitro. Neuroendocrinology. 47: 303-308.

107. Giuffre K, Udelsman R, Listwak S, Chrousos GP. (1988) Effects of Immune Neutralization of CRH, ACTH, and Endorphin in the Surgically Stressed Rat. Endocrinology. 122: 306-310.

108. Feuillan P, Pang S, Avgerinos P, Schuermeyer T, Chrousos GP. (1988) Adaptation of the Hypothalamic- pituitary-adrenal Axis in Patients with Partial (Late-onset) 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 67: 154-160.

109. Margioris A, Grino M, Protos P, Gold PW, Chrousos GP. (1988) Corticotropin Releasing Hormone and Oxytocin Stimulate the Secretion of Immunoreactive alpha-MSH, beta-Endorphin and ACTH from the Human Placenta In Vitro. J Clin Endocrinol Metab. 66: 922-926.

110. Laue L, Kawai S, Brandon D, Knazek R, Loriaux DL, Chrousos GP. (1988) Receptor-Mediated Effects of Glucocorticoids on Inflammation: Enhancement of the Inflammatory Response with a Glucocorticoid Antagonist. J Steroid Biochem. 29: 591-598.

111. Luger A, Deuster P, Kyle SB, Gallucci WT, Montgomery LC, Loriaux DL, Chrousos GP. (1988) Renin- angiotensin Responses during Treadmill Exercise. Hormone Res. 30: 5-9.

112. Laue L, Gallucci W, Loriaux DL, Udelsman R, Chrousos GP. (1988) The Antiglucocorticoid and Antiprogestin Steroid RU 486: Its Glucocorticoid Agonist Effect is Inadequate to Prevent Adrenal Insufficiency in Primates. J Clin Endocrinol Metab. 67: 602-606.

113. Calogero AE, Gallucci WT, Chrousos GP, Gold PW. (1988) Interaction between Gabaergic Neurotransmission and Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro. Brain Res. 463: 28-36.

114. Calogero AE, Gallucci WT, Chrousos GP, Gold PW. (1988) Effect of the Catecholamines Upon Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro: Clinical Implications. J Clin Invest. 82: 839-846.

115. Calogero A, Gallucci WT, Gold PW, Chrousos GP. (1988) Multiple Regulatory Feedback Loops on Hypothalamic Corticotropin Releasing Hormone Secretion. J Clin Invest. 82: 767-774.

116. Doppman JL, Frank JA, Dwyer AJ, Oldfield EH, Miller DL, Nieman LK, Chrousos GP, Cutler GB Jr, Loriaux D.L. (1988) Gadolinium DPTA Enhanced MR Imaging of ACTH-Secreting Microadenomas of the Pituitary 18

George P. Chrousos, M.D.

Gland. J Comp Assist Tom. 12: 728-735.

117. Laue L, Peacock J, Gallucci WT, Brandon DD, Cutler GB Jr, Loriaux DL, Chrousos GP, Norton JA. (1988) Glucocorticoid Receptor-mediated Effects on Rat Fibrosarcoma Growth. Cancer Res. 48: 2703-2706.

118. Deuster P, Chrousos GP, Luger A, Kyle SB, Gallucci WT, Montgomery LC, Loriaux DL. (1989) Sympathetic System Responses to the Stress of Treadmill Exercise. Physiologic Adaptations to Physical Training. Metabolism 38: 141-148.

119. Calogero AE, Bernardini R, Margioris AN, Gallucci WT, Munson PJ, Tamarkin L, Tomai TP, Brody L, Gold PW, Chrousos GP. (1989) Serotonin Stimulates Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro. Peptides. 10: 189-210.

120. Kawai S, Brandon D, Loriaux DL, Chrousos GP. (1989) Interaction of RU 486, A Glucocorticoid and Progesterone Antagonist, with Human Circulating Mononuclear Leukocytes. Am J Med Sci. 296: 167-171.

121. Friedman RB, Oldfield EH, Nieman LK, Chrousos GP, Doppman JL, Cutler GB Jr, Loriaux DL. (1989) Repeat Transsphenoidal Surgery in Cushing's Disease. J Neurosurg. 71: 520-527.

122. Margioris A, Koukoulis G, Grino M, Chrousos GP. (1989) In Vitro Perifused Rat Testis Fragments Secrete beta-Endorphin and Dynorphin: Effect of Opioids on Testosterone Secretion. Biol Reprod. 40: 776-784.

123. Perry RR, Nieman LK, Cutler GB Jr, Chrousos GP, Loriaux DL, Doppman JL, Travis WD, Norton JA. (1989) Primary Adrenal Causes of Cushing's Syndrome: Diagnosis and Surgical Management. Ann Surg. 210: 59-68.

124. Sternberg E, Hill JM, Chrousos GP, Kamilaris T, Listwak S, Gold PW, Wilder RL. (1989) Inflammatory mediator-induced Hypothalamic-pituitary-adrenal Axis Activation is Defective in Streptococcal Cell Wall Arthritis - susceptible Lewis Rats. Proc Natl Acad Sci. USA 86: 2374-2378.

125. Gomez MT, Chrousos GP. (1989) Periodic Cushing's Syndrome in a Short Boy: Usefulness of the Ovine CRH Test. J Pediatr. 115: 270-273.

126. Linder B, Feuillan P, Chrousos GP. (1989) Alternate-day Prednisone Therapy in Congenital Adrenal Hyperplasia: Adrenal Androgen Suppression and Normal Growth. J Clin Endocrinol Metab. 69:91-195.

127. Bagdy G, Calogero A, Chrousos GP, Szemeredi K. (1989) Delayed Effects of Chronic Cortisol Treatment on Brain and Plasma Concentrations of Corticotropin (ACTH) and beta-Endorphin. Brain Res. 489: 216-222.

128. Sternberg EM, Young WS Jr, Bernardini R, Calogero A, Chrousos GP, Gold PW, Wilder RL. (1989) A Central Nervous Defect in the Stress Response is Associated with Susceptibility to Streptococcal Cell Wall Arthritis in Lewis Rats. Proc Natl Acad Sci. 86: 4771-4775.

129. Bernardini R, Chiarenza A, Calogero AE, Gold PW, Chrousos GP. (1989) Arachidonic Acid Metabolites Modulate Rat Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro. Neuroendocrinology. 50: 708-715.

130. Bernardini R, Calogero AE, Ehlich YH, Brucke T, Chrousos GP, Gold PW. (1989) The Alkyl- ether Phospholipid Platelet-activating Factor is a Stimulator of the Hypothalamic-pituitary-adrenal Axis in the Rat. Endocrinology. 125: 1067-1073.

131. Calogero A, Gallucci WT, Chrousos GP, Gold PW. (1989) Cocaine Stimulates Rat Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro. Brain Res. 505: 7-11.

132. Doppman JL, Pass HI, Nieman L, Cutler GB Jr, Chrousos GP, Loriaux DL. (1989) Failure of Bronchial Lavage to Select Elevated Levels of ACTH in Patients with ACTH-Producing Bronchial Carcinoids. J Clin Endocrinol Metab. 69: 1302-1304. 19

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133. Travis WD, Tsokos M, Doppman JL, Nieman L, Chrousos GP, Cutler GB, Loriaux DL, Norton JA. (1989) Primary Pigmented Nodular Adrenocortical Disease: A Light and Electron Microscopic Study of Eight Cases. Am J Surg Pathol. 13: 921-930.

134. Calogero A, Kamilaris T, Gomez MT, Johnson EO, Tartaglia E, Gold PW, Chrousos GP. (1989) The Muscarinic Cholinergic Agonist Arecoline Stimulates the Rat Hypothalamic-pituitary-adrenal Axis Through a Centrally-mediated Corticotropin-releasing Hormone Mechanism. Endocrinology. 125: 2445-2453.

135. Doppman JL, Travis WD, Nieman LK, Miller DL, Pass HI, Chang R, Cutler GB Jr, Chrousos GP, Norton JA, Ziessman HA, Oldfield EH, Loriaux DLv. (1989) Cushing's Syndrome Due to Primary Pigmented Nodular Adrenocortical Disease: Findings at CT and MR Imaging. Radiology. 172(2):415-420.

136. Doppman JL, Nieman LK, Miller DL, Pass HI, Chung R, Cutler G, Schauf M, Chrousos GP, Norton JA, Zirrsman HA, Oldfield EH, Loriaux DL. (1989) Ectopic Adrenocorticotropin Hormone Syndrome: Localization Studies in 28 Patients. Radiology. 172: 115-124.

137. Nieman LK, Cutler GB Jr, Oldfield EO, Loriaux DL, Chrousos GP. (1989) The Ovine Corticotropin Releasing Hormone Stimulation Test is Superior to the Human Cortico- tropin Releasing Hormone Test for the Detection of Cushing's Disease. J Clin Endocrinol Metab. 69: 165-169.

138. Marx SJ, Jones G, Weinstein RJ, Chrousos GP, Renquist D. (1989) Vitamin D and Mineral Metalbolism in New World and Old World Primates: A Novel State with Hyperphosphatetic Osteomalacia in Aotus trivirgatus. J Olin Endocrinol Metab. 69:1282-1290.

139. Pass HI, Doppman JL, Nieman L, Stovroff M, Veto J, Norton JA, Travis W, Chrousos GP, Cutler GB Jr. (1990) Management of the Ectopic ACTH Syndrome Due to Thoracic Carcinoids. Ann Thorac-Surg. 50: 52- 57.

140. Calogero A, Kling MA, Gallucci WT, Bernardini R, Chrousos GP, Gold PW. (1990) Procaine and Lidocaine Stimulate Corticotropin Releasing hormone Secretion by Explanted Rat Hypothalami through a Sodium Conductance Independent Mechanism. Horm Metab.Res. 22: 1-4.

141. Dorn L, Susman EJ, Nottelmann ED, Inoff-Germain G, Chrousos GP. (1990) Perceptions of Puberty: Adolescent, Parent, and Health Care Personnel Ratings of Pubertal Stage. Develop Psych. 26: 322-329.

142. Gazdar AF, LaRocca RV, Chen TR, Triche TJ, Myers CE, Chrousos GP, Brennan MR, Stein CA, Oie HK. (1990) Establishment and Characterization of a Human Adrenocortical Carcinoma Cell Line That Expresses Multiple Pathways of Steroid Biosynthesis. Cancer Res. 50: 5488-5496.

143. Rabin D, Johnson E, Brandon D, Liapi C, Chrousos GP. (1990) Glucocorticoids Inhibit Estradiol- induced Uterine Growth: Possible Role of Estrogen Receptors. Biol Reprod. 42: 74-80.

144. Calogero AE, Kamilaris TC, Bernardini R, Johnson EO, Chrousos GP, Gold PW. (1990) Relevance of the "Peripheral" Benzodiazepine Receptor System to Hypothalamic pituitary-adrenal Function: Physiological and Clinical Implications. J Pharmacol Exp Therap. 253: 729-737.

145. Margioris A, Brockmann G, Bohler H, Grino M, Vamvakopoulos N, Chrousos GP. (1990) Expression and Localization of Growth Hormone - Releasing Hormone mRNA in Rat Placenta: In Vitro Secretion and Regulation of Its Peptide Product. Endocrinology. 126: 151-158.

146. Malozowski S, Muzzo S, Burrows R, Leiva L, Loriaux L, Chrousos GP, Winterer J, Cassorla F. (1990) The Hypothalamic-pituitary-adrenal Axis in Infantile Malnutrition. Clin Endocrinol. 32:461-465.

147. Calogero AE, Bagdy G, Szemereti K, Tartaglia ME, Gold PW, Chrousos GP. (1990) Mechanisms of Serotonin Agonist-induced Activation of the Hypothalamic-pituitary-adrenal Axis in the Rat. Endocrinology. 126: 1888- 20

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1894.

148. Margioris AN, Brockmann G, Kalogeras K, Fjellestad-Paulsen A, Stratakis CA, Vamvakopoulos N, Chrousos GP. (1990) Effect of Hypertonic Saline Infusion on the Levels of Immunoreactive Dynorphin in Extracted Human Plasma. J Clin Endocrinol Metab. 71: 298-304.

149. Bernardini R, Kamilaris TC, Calogero AE, Johnson EO, Gold PW, Chrousos GP. (1990) Interactions Between Tumor Necrosis Factor-, Hypothalamic Corticotropin-Releasing Hormone and Adrenocorticotropin Secretion in the Rat. Endocrinology. 126: 2876-81.

150. Calogero A, Kamilaris T, Johnson EO, Tartaglia M, Chrousos GP. (1990) Recovery of the Rat Hypothalamic- pituitary-adrenal Axis after Prolonged Treatment with Dexamethasone. Endocrinology. 127: 1574-1579.

151. Vamvakopoulos N, Karl M, Mayol V, Margioris A, Chrousos GP. (1990) Structural Analysis of the Regulatory Region of the Human Corticotropin Releasing Hormone Gene. FEBS Lett. 267:1-5.

152. Kalogeras KT, Calogero AE, Kuribayashi T, Khan I, Gallucci WT, Kling MA, Chrousos GP, Gold PW. (1990) In vitro and In vivo Effects of the Triazolobenzodiazepine Alprazolam on Hypothalamic-pituitary-adrenal Function: Pharmacologic and Clinical Implications. J Clin Endocrinol Metab. 70: 1462-1471.

153. Rabin D, Schmidt P, Campbell G, Gold PW, Jensvold M, Rubinow D, Chrousos GP. (1990) Hypothalamic- pituitary-adrenal Function in Patients with the Premenstrual Syndrome. J Clin Endocrinol Metab. 71: 1158- 1162.

154. Doherty JM, Nieman LK, Cutler GB, Chrousos GP, Norton J. (1990) Time to Recovery of the Hypothalamic Pituitary-Adrenal Axis Following Curative Resection of Adrenal Tumors in Patients with Cushing's Syndrome. Surgery. 108:1085-90.

155. Hurley D, Accilli D, Stratakis C, Karl M, Vamvakopoulos N, Rorer E, Constantine K, Taylor S, Chrousos GP. (1991) Point Mutation Causing a Single Amino Acid Substitution in the Hormone Binding Domain of the Glucocorticoid Receptor in Familial Glucocorticoid Resistance. J Clin Invest. 87:680-686.

156. Laue L, Lotze MT, Chrousos GP, Barnes K, Loriaux DL, Fleisher TA. (1990) Effects of the Glucocorticoid Antagonist RU 486 in Man: Toxicity, Immunological and Hormonal Aspects. J Clin Endocrinol Metab. 71:1474-1480.

157. Gomez MT, Malozowski S, Winterer J, Chrousos GP. (1991) Urinary Free Cortisol Values in Normal Children and Adolescents. J Pediatrics 118:256-258.

158. Bernardini R, Calogero A, Mauceri G, Chrousos GP. (1990) Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro is Stimulated by Interleukin-1 in an Eicosanoid-dependent Manner. Life Sciences 47:1601-7.

159. Bagdy G, Calogero A, Szemeredi K, Gomez MT, Sved AF, Murphy DL, Chrousos GP, Gold PW. (1990) Endorphin Responses to Different Serotonin Agonists: Involvement of Corticotropin Releasing Hormone, Vasopressin and Direct Pituitary Action. Brain Res. 537(1-2):227-32.

160. Bagdy G, Calogero A, Szemeredi K, Chrousos GP, Gold PW. (1990) effects of Cortisol Treatment on Brain and Adrenal Cortcotropin Releasing Hormone Content. Regulat Peptides. 31:83-92.

161. Doppman JL, Nieman LK, Travis WD, Miller DL, Cutler GB, Chrousos GP, Norton JA. (1991) CT and MR Imaging of Massive Macronodular Adrenocortical Disease: A Rare Cause of Autonomous Primary Adrenal Hypercortisolism. J Comp Asst Tom. 15:773-779.

162. Bagdy G, Chrousos GP, Calogero A. (1991) Circadian Patterns of Plasma Corticotropin, - Endorphin, Corticosterone and Prolactin after Immunoneutralization of Corticotropin-releasing Hormone. 21

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Neuroendocrinology. 53:573-578.

163. Vanderpool J, Rosenthal N, Chrousos GP, Wehr T, Skewerer R, Kasper S, Gold PW. (1991) Evidence for Hypothalamic CRH Deficiency in Patients with Seasonal Affective Disorder. J Clin Endocrinol Metab. 72:1382-1387.

164. Doppman J, Pass H, Nieman LK, Findling J, Dwyer A, Feuerstein I, Ling A, Travis W, Cutler GB, Chrousos GP, Loriaux DL. (1991) Magnetic Resonance Imaging for Detection of ACTH- producing Bronchial Carcinoid Tumors. Am J Roentgen. 156:39-43.

165. Johnson EO, Kamilaris TC. Carter S, Gold PW, Chrousos GP. (1991) Environmental Stress and Reproductive Success in the Common Marmoset (Callithrix jacchus jacchus). Am J Primatol 25:191- 201.

166. Kling MA, Doran A, Rubinow DR, Roy A, Post RM, Chrousos GP, Gold PW. (1991) CSF Levels of CRH, ACTH, and SRIF in Cushing's Syndrome, Major Depression, and Normal Volunteers: Physiological and Pathophysiological Interrelationships. J Clin Endocrinol Metab. 72:260-271.

167. Laue L, Peck G, Gallucci WT, Loriaux DL, Chrousos GP. (1991) Adrenal Androgen Secretion in Postadolescent Cystic Acne: Increased Adrenocortical Function without Hypersensitivity to ACTH. J Clin Endocrinol Metab. 73:380-384.

168. Calogero AE, Liapi C, Chrousos GP. (1991) Hypothalamic and Suprahypothalamic Effects of Prolonged treatment with the Glucocorticoid Type II Receptor Agonist Dexamethasone in the Rat. J Endocrinol Invest. 14:277-286.

169. Smoak B, Deuster P, Rabin D, Chrousos GP. (1991) Corticotropin-Releasing Hormone is Not the Sole Factor Mediating Exercise-induced ACTH Release in Humans. J Clin Endocrinol Metab. 72:302-306.

170. Sombolos K, Kapetanos G, Kalogeras KT, Christodoulou A, Chrousos GP, Symeonidis P. (1991) Effect on Atrial Natriuretic Peptide by Bracing in Scoliosis. Boston Brace Removal Studied in 10 cases. Acta Orthop Scand. 62:379-82.

171. Waltman C, Blackman MR, Chrousos GP, Riemann C, Harman SM. (1991) Spontaneous and Glucocorticoid- inhibited Adrenocorticotropic Hormone and Cortisol Secretion Are Similar in Healthy Young and Old Men. J Clin Endocrinol Metab. 73:495-502.

172. Perini GI, Dervinsky O, Hauser P, Gallucci WT, Theodore W, Chrousos GP, Gold PW, Kling MA. (1992) Effects of Carbamazepine on Pituitary-adrenal Function in Healthy Volunteers. J Clin Endocrinol Metab. 74:406-412.

173. Travis WD, Linnoila R, Tsokos M, Hitchcock C, Cutler G, Nieman L, Chrousos GP, Pass H, Doppman J. (1991) Neuroendocrine Tumors of the Lung with Proposed Criteria for Large Cell Neuroendocrine Carcinoma: An Ultrastructural, Immunochemical, and Flow Cytometric Study of 35 Cases. Amer J Surg Path. 15:529-553.

174. Demitrack M, Dale J, Straus S, Laue L, Listwak S, Kruesi M, Chrousos GP, Gold PW. (1991) Evidence of Impaired Activation of the Hypothalamic-pituitary-adrenal Axis in Patients with Chronic Fatigue Syndrome. J Clin Endocrinol Metab. 73:1224-1234.

175. Karalis C, Sano H, Redwine J, Listwak S, Wilder R, Chrousos GP. (1991) Autocrine or Paracrine Inflammatory Actions of Corticotropin Releasing Hormone In Vivo. Science 254:421-423.

176. Friedman TC, Thomas PM, Fleisher TA, Feuillan P, Parker RI, Cassorla F, Chrousos GP. (1991) Frequent Occurrence of Asplenism and Cholelithiasis in Patients with Autoimmune Polyglandular Disease Type I. Amer J Med. 91:625-630.

177. Oldfield EH, Doppman J, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler GB, Loriaux DL. (1991) 22

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Petrosal Sinus Sampling with and without Corticotropin Releasing Hormone in Patients with Cushing's Syndrome. N Engl J Med. 325:897-905.

178. Susman EJ, Dorn LD, Chrousos GP. (1991) Negative Affect and Hormone Levels in Young Adolescents: Concurrent and Predictive Perspectives. J Youth Adolesc. 20:167-190.

179. Calogero A, Sternberg E, Bagdy G, Smith G, Bernardini R, Aksentijevich S, Wilder RL, Gold PW, Chrousos GP. (1992) Neurotransmitter-induced Hypothalamic-pituitary-adrenal Axis Responsiveness is Defective in Inflammatory Disease-Susceptible Lewis Rats: In vivo and In vitro Studies Suggesting Globally Defective Hypothalamic CRH Secretion. Neuroendocrinology. 55:600-608.

180. Calogero AE, Norton JA, Sheppard BC, Listwak SJ, Cromack DT, Wally R, Jensen RT, Chrousos GP. (1992) Pulsatile Activation of the Hypothalamic - pituitary - adrenal Axis during Major Surgery. Metabolism. 41:839- 845.

181. Aksentijevich S, Whitfield Jr HJ, Young III WS, Wilder RL, Chrousos GP, Gold PW, Sternberg EM. (1992) Arthritis-susceptible Lewis Rats Fail to Emerge from the Stress Non-responsive period. Dev Brain Res. 65:115-118.

182. Flack MR, Oldfield EH, Cutler GB, Zweig MH, Melley JD, Chrousos GP, Loriaux DL, Nieman LK. (1992) The Use of Urine Free Cortisol in the High Dose Dexamethasome Suppression Test for the Differential Diagnosis of Cushing's Syndrome. Ann Int Med. 116:211-217.

183. Kamilaris T, Johnson E, Calogero AE, Kalogeras K, Bernardini R, Chrousos GP, Gold PW. (1992) Cholecystokinin-octapeptide Stimulates Hypothalamic-pituitary-adrenal Function in Rats: Role of Corticotropin-releasing Hormone. Endocrinology. 130:1764-1784.

184. Calogero AE, Kamilaris TC, Johnson EO, Gold PW, Chrousos GP. (1992) "Peripheral" Benzodiazepine receptor Ligands Stimulate Prolactin Release in the Rat. J Neuroendocrinology. 2:745-750.

185. Luger A, Watschinger B, Deuster P, Svoboda T, Clodi M, Chrousos GP. (1992) Plasma Growth Hormone and Prolactin Responses to Graded Levels of Acute Exercise and to a Lactate Infusion. Neuroendocrinology. 56:112-117.

186. Marini JC, Bordenick S, Heavner G, Rose S, Hintz R, Rosenfeld R, Chrousos GP. (1993) The Growth Hormone and Somatomedin Axis In Short Children with Osteogenesis Imperfecta. J Clin Endocrinol Metab. 76:251-256.

187. Vamvakopoulos N, Mayol V, Margioris N, Chrousos GP. (1992) Lack of Dexamethasone Modulation of mRNAs involved in the Glucocorticoid Signal Transduction Pathway in Two Cell Systems. Steroids. 57:1-6.

188. Cash JM, Crofford LJ, Gallucci WT, Sternberg EM, Gold PW, Chrousos GP, Wilder RL. (1992) Pituitary- adrenal Axis Responsiveness to Ovine CRH in Patients with Rheumatoid Arthritis Treated with Low-dose Prednisone. J Rheumatol. 19:1692-6.

189. Deuster PA, Singh A, Hofmann A, Moses FM, Chrousos GP. (1992) Hormonal Responses to Ingesting Water or a Carbohydrate Beverage During a 2h Run. Med Sci Sport Exerc. 24:72-79.

190. Burnet P, Meffor IN, Smith CC, Chrousos GP, Gold PW, Sternberg EM. (1992) Hippocampal [3H]-8-hydroxy- 2,3-(diphenylalanine)-tetralin binding site densities, serotonin receptor (5-HT1A) messenger ribonucleic acid abundance and serotonin levels parallel the activity of the hypothalamopituitary-adrenal axis in rat. J Neurochemistry. 59:1062-1070.

191. Sternberg EM, Glowa J, Smith MA, Calogero AE, Listwak SJ, Aksentijevich S, Chrousos GP, Wilder RL, Gold PW. (1992) Corticotropin Releasing Hormone Related Behavioral and Neuroendocrine Responses to Stress in Lewis and Fischer Rats. Brain Res. 570:54-60. 23

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192. Roy MS, Roy A, Gallucci WT, Collier B, Young K, Kamilaris TC, Chrousos GP. (1993) The Ovine Corticotropin Releasing Hormone Test in Type I Diabetic Patients and Controls: Suggestion of Mild Chronic Hypercortisolism. Metabolism. 42:696-700.

193. Patchev V, Kalogeras K, Zelazowski P, Wilder RL, Chrousos GP. (1992) Increased Plasma Concentrations and Hypothalamic Content and In Vitro Release of Arginine-Vasopressin in Inflammatory Disease-prone, Hypothalamic CRH-deficient Lewis Rats. Endocrinology. 131:1453-1457.

194. Kling A, Rubinow DR, Doran AR, Roy A, Davis CL, Calabrese JR, Nieman LK, Post RM, Chrousos GP, Gold PW. (1993) Cerebrospinal Fluid Immunoreactive Somatostatin Concentrations in Patients with Cushing's Disease and Major Depression: Relationship to Indices of Corticotropin-Releasing Hormone and Cortisol Secretion. Neuroendocrinology. 57:79-88.

195. Chikanza IC, Petrou P, Chrousos GP, Kingsley G, Panayi G. (1992) Detective Hypothalamic Response to Immune/Inflammatory Stimuli in Patients with Rheumatoid Arthritis. Arthritis and Rheumatism. 35:1281- 1288.

196. Karl M, Lamberts SW, Detera-Wadleigh S, Encio IJ, Stratakis CA, Hurley DM, Accili D, Chrousos GP. (1993) Familial Glucocorticoid Resistance Caused by a Splice Site Deletion in the Human Glucocorticoid Receptor Gene. J Clin Endocrinol Metab. 76:683-89.

197. Crofford LJ, Sano H, Karalis K, Webster EL, Goldmuntz EA, Chrousos GP, Wilder RL. (1992) Local Secretion of Corticotropin Releasing Hormone in the Joints of Lewis Rats with Inflammatory Arthritis. J Clin Invest. 90:2555-2564.

198. Doppman JL, Pass HI, Nieman LK, Miller DL, Chang R, Cutler GB, Chrousos GP, Jaffe GS, Norton JA. (1992) Corticotropin-secreting Carcinoid Tumors of the Thymus: Diagnostic Unreliability of Thymic Venous Sampling. Radiology. 184:71-74.

199. Cizza G., Brady L., Calogero A., Bagdy G., Lynn A.B., Kling M.A., Blackman M.R., Chrousos G. P., Gold P.W. (1992) Central Hypothyroidism is Associated with Advanced Age in Male Fischer 344/N Rats: In Vivo and In Vitro Studies. Endocrinology 131:2672-2680.

200. Smith CC, Hauser E, Renaud NK, Leff A, Aksentijevich S, Chrousos GP, Wilder RL, Gold PW, Sternberg EM. (1992) Increased Hypothalamic 3H-Flunitrazepam Binding in Hypothalamic- Pituitary-Adrenal Axis Hyporesponsive Rats. Brain Res. 569:295-299.

201. Zelitch Yanovski S, Yanovski JA, Gwirtsman HE, Bernat A, Gold PW, Chrousos GP. (1993) Normal Dexamethasone Suppression in Obese Binge and Non-binge Eaters with Rapid Weight Loss. J Clin Endocrinol Metab. 76:675-79.

202. Yanovski JA, Cutler GB, Chrousos GP, Nieman LK. (1993) Corticotropin-releasing Hormone stimulation following low-dose dexamethasone administration: A new test to distinguish Cushings syndrome from Pseudo- Cushings states. JAMA. 269:2232-38.

203. Zelazowski P, Smith MA, Gold PW, Chrousos GP, Wilder RL, Sternberg E.M. (1992) In Vitro Regulation of Pituitary ACTH Secretion in Inflammatory Disease Susceptible Lewis and Inflammatory Disease Resistant Fischer Rats. Neuroendocrinology. 56:474-482.

204. Bouzas EA, Mastorakos G, Chrousos GP, Kaiser-Kupfer MI. (1993) Lisch Nodules in Cushing Disease. Archives Ophthalmol. 111:439-40.

205. Swain MG, Patchev V, Vergalla T, Chrousos GP, Jones EA. (1993) Suppression of Hypothalamic- pituitary- adrenal Axis Responsiveness to Stess in a Rat Model of Acute Cholestasis. J Clin Invest. 91:1903-1908.

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206. Cizza G, Kvetnansky R, Tartaglia ME, Blackman MR, Chrousos GP, Gold PW. (1993) Immobilization Stress Rapidly Decreases Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro in the male 344/N Fischer Rat. Life Sciences. 53:233-240.

207. Crofford LJ, Sano H, Karalis K, Friedman TC, Epps HR, Remmers EF, Mathern P, Chrousos GP, Wilder RL. (1993) Corticotropin-releasing Hormone in Synovial Fluids and Tissues of Patients with Rheumatoid Arthritis and Osteoarthritis. J Immunology. 151:1-10.

208. Chikanza IC, Petrou P, Chrousos GP, Kingsley G, Panayi GS. (1993) Excessive and Dysregulated Secretion of Prolactin in Rheumatoid Arthritis: Immunopathogenetic and Therapeutic Implications. Br J Rheumatol. 32:445-448.

209. Gomez MT, Magiakou MA, Mastorakos G, Chrousos GP. (1993) The Pituitary Corticotroph is not the Rate Limiting Step in the Postoperative Recovery of the Hypothalamic-pituitary-adrenal Axis in Patients with Cushing's Syndrome. J Clin Endocrinol. Metab. 77:173-77.

210. Vamvakopoulos NC, Chrousos GP. (1993) Regulated Activity of the Distal Promoter-like Element of the Human Corticotropin-Releasing Hormone Gene and Secondary Structural Features of its Corresponding Transcripts. Mol Cell Endocrinol. 94:73-78.

211. Mastorakos G, Webster EL, Friedman TC, Chrousos GP. (1993) Immunoreactive Corticotropin Releasing Hormone (CRH) and its Binding Sites in the Rat Ovary. J Clin Invest. 92:961-968.

212. Vamvakopoulos NC, Fukuhara K, Patchev VK, Chrousos GP. (1993) Effect of Single and Repeated Immobilization Stress on the Heat Shock Protein (HSP) 70/90 System in the Rat: Glucocorticoid-Independent, Reversible Reduction of HSP90 in the Liver and Spleen. Neuroendocrinology. 57:1057-1065.

213. Yanovski JA, Yanovski SZ, Gold PW, Chrousos GP. (1993) Differences in the Hypothalamic- Pituitary- Adrenal Axis of Black and White Women. J Clin Endocrinol Metabol. 77:536-541.

214. Yanovski JA, Cutler GB, Doppman JL, Miller DL, Chrousos GP, Oldfield EH, Nieman LK. (1993) The Limited Ability of Inferior Petrosal Sinus Sampling with Corticotropin-Releasing Hormone in Distinguishing Cushing Disease from Pseudo-Cushing States or Normal Physiology. J Clin Endocrinology Metab. 77:503-509.

215. Vamvakopoulos NC, Chrousos GP, Griffin CA, Hawkins AL, Lee C, Jabs EW. (1993) Mapping the Intron- containing Human hsp 90 (hspCAL4) Gene to Chromosome 14G32. Cytogenet Cell Gen. 64:224-226.

216. Bouzas EA, Scott MH, Mastorakos SG, Gold PW, Chrousos GP, Kaiser-Kupfer MI. (1993) Central Serous Chorioretinopathy in Endogenous Hypercortisolism. Arch Ophthalmol. 111:1229-33.

217. Vamvakopoulos NC, Chrousos GP. (1993) Evidence of Direct Estrogen Regulation of Human Corticotropin Releasing Hormone Gene Expression: Potential Implications for the Sexual Dimorphism of the Stress Response and Immune/Inflammatory Reaction. J. Clin Invest. 92:1896-1902.

218. Patchev VK, Mastorakos G, Brady LS, Redwine J, Wilder RL, Chrousos GP. (1993) Increased Arginine Vasopressin Secretion May Participate in the Enhanced Susceptibility of Lewis Rats to Inflammatory Disease. Neuroendocrinology. 58:106-110.

219. Reincke M, Karl M, Travis W, Chrousos GP. (1993) No Evidence for Oncogenic Mutations in Guanine Nucleotide Binding Proteins of Human Adrenocortical Neoplasms. J Clin Endocrin Metabol. 77:1419-1422.

220. Tsigos C, Arai K, Hung W, Chrousos GP. (1993) Hereditary Isolated Glucocorticoid Deficiency is Associated with Abnormalilties of the Adrenocorticotropin Receptor Gene. J Clin Invest. 92:2461-2485.

221. Vamvakopoulos NC, Durkin S, Nierman W, Chrousos GP. (1993) Mapping the Human Adrenocorticotropin Hormone (ACTHR) Gene to the Small Arm of Chromosome 18 (18p. 11.21- pter.) Genomics. 18:454-455. 25

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222. Gallucci WT, Baum A, Laue L, Rabin DS, Chrousos GP, Gold PW, Kling MA. (1993) Sex Differences in Sensitivity of the Hypothalamic-Pituitary Adrenal Axis. Health Psychology. 12:420-425.

223. Mastorakos G, Chrousos GP, Weber J. (1993) Recombinant Interleukin 6 Activates the Hypothalamic- Pituitary-Adrenal Axis in Humans. J Clin Endocrinol Metab. 27:1690-1694.

224. Reincke M, Allolio B, Petzke F, Heppner C, Mbulamberi D, Winklemann W, Chrousos GP. (1993) Thyroid Dysfunction in African Trypanosomiasis: Evidence for Cytokine-Mediated Hypothyroidism. Clin Endocrinol. 39:455-461.

225. Nieman LK, Oldfield EH, Wesley R, Chrousos GP, Loriaux DL, Cutler GB Jr. (1993) A simplified Morning Ovine Corticotropin-Releasing Hormone Stimulation Test for the Differential Diagnosis of ACTH-dependent Cushing's Syndrome. J Clin Endocrinol Metab.77:1308-1312.

226. Reincke M, Allolio B, Arlt W, Heppner C, Petcke F, Mbulamberi D, Siekman L, Vollmer D, Winkleman W, Chrousos GP. (1994) Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis Factor-alpha and Interleukin-6 Concentrations in African Trypanosomiasis. NeuroImmunoModulation. 1:14-22.

227. Doppman J, Nieman LK, Cutler GB Jr, Chrousos GP, Fraker DL, Norton JA, Jensen RT. (1994) Adrenocorticotropin Hormone-Secreting Islet Cell Tumors: Are They Always Malignant? Radiology. 190:59- 64.

228. Zeiger MA, Fraker DL, Pass HI, Nieman LK, Cutler GB Jr, Chrousos GP, Norton JA. (1993) Effective Reversibility of the Signs and Symptoms of Hypercorticosolism by Bilateral Adrenalectomy. Surgery 114:1138-43.

229. Bouzas EA, Mastorakos G, Friedman TC, Scott MH, Chrousos GP, Kaiser-Kupfer MI. (1993) Posterior Subcapsular Cataract in Endogenous Cushing Syndrome: An Uncommon Manifestation. Invest Ophthalmol Vis Sci. 34:3497-3500.

230. Magiakou MA, Mastorakos G, Gomez MT, Rose SR, Chrousos GP. (1994) Suppressed Spontaneous and Stimulated Growth Hormone Secretion in Patients with Cushing Disease Before and After Surgical Cure. J Clin Endocrinol Metab. 78:131-137.

231. Zelazowski P, Patchev VK, Zelazowski EB, Chrousos GP, Gold PW, Sternberg EM. (1993) Release of Hypothalamic Corticotropin-Releasing Hormone and Arginine Vasopressin by Interleukin-1 and -MSH: Studies in Rats with Different Susceptibility to Inflammatory Disease. Brain Res. 631:22-26.

232. Ram Z, Nieman LK, Cutler GB Jr, Chrousos GP, Doppman J, Oldfield EH. (1994) Early Repeat Surgery for Persistent Cushing's Disease. J Neurosurg. 80:37-45.

233. Patchev VK, Karalis K, Chrousos GP. (1994) Effect of Excitatory Amino Acid Transmitters on Hypothalamic Corticotropin-Releasing Hormone (CRH) and Arginine Vasopressin Release: Implications for Pituitary- Adrenal Regulation. Brain Res. 633:312-316.

234. Vamvakopoulos NC, Chrousos GP. (1993) Structural Organization of the 5' Flanking Region of the Human Corticotropin Releasing Hormone Gene. J DNA Sequencing and Mapping. 4:197-206.

235. DeBellis M, Chrousos GP, Dorn L, Burke L, Helmers K, Kling MA, Trickett PK, Putnam FW. (1994) Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Sexually Abused Girls. J Clin Endocrinol Metab. 78:249-255.

236. Kling M, Demitrack M, Whitfield H Jr, Kalogeras K, Listwak S, DeBellis M, Chrousos GP, Gold PW, Brandt H. (1993) Effects of the Glucocorticoid Antagonist RU 486 on Pituitary-Adrenal Function in Patients with 26

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Anorexia Nervosa and Healthy Volunteers: Enhancement of Plasma ACTH and Cortisol Secretion in Underweight Patients. Neuroendocrinol. 57:1082-1091.

237. Reincke M, Karl M, Travis W, Mastorakos G, Allolio B, Linehan MH, Chrousos GP. (1994) P53 Mutations in Human Adrenocortical Neoplasms: Immunohistochemical and Molecular Studies. J Clin Endocrinol Metab. 78:790-794.

238. Cizza G, Kalogeras AE, Brady LS, Bagdy G, Bergamini E, Blackman MR, Chrousos GP, Gold PW. (1994) Male 344 Fischer Rats Show a Progressive Central Impairment of the Hypothalamic-Pituitary-Adrenal-Axis with Advancing Age. Endocrinology. 134:1611-1620.

239. Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Stambuk MK, Dorn GB Jr, Nieman LK, Chrousos GP. (1994) Diurnal Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for Positive Correlation with Body Temperature and Negative Correlation with REM Slow Wave Sleep. J Clin Endocrin & Metab. 78:1085-1089.

240. Karalis K, Mastorakos G, Chrousos GP, Tolis G. (1994) Somatostatin Analogs Suppress the Inflammatory Reaction In Vivo. J Clin Invest. 93:2000-2006.

241. Kawatito Y, Sano H, Kawata M, Yuri K, Yamamura Y, Kato H, Chrousos GP, Wilder RL, Kondo M. (1994) Local Secretion of Corticotropin Releasing Hormone by Enterochromafin Cells in Human Colon. Gastroenterology. 106:859-65.

242. Magiakou MA, Mastorakos G, Oldfield EH, Gomez MT, Doppman JL, Cutler GB Jr, Nieman LK, Chrousos GP. (1994) Cushing Syndrome in Children and Adolescents: Presentation, Diagnosis and Therapy. N Engl J Med. 331:629-36.

243. Auchus RJ, Mastorakos G, Friedman TC, Chrousos GP. (1994) Corticotropin-Releasing Hormone Production by a Small Cell Carcinoma in a Patient with ACTH-dependent Cushing Syndrome. J Endocrinol Invest. 17:447-452.

244. Petrides JS, Mueller GP, Kalogeras KT, Chrousos GP, Gold PW, Deuster PA. (1994) Exercise- induced Activation of the Hypothalamic-Pituitary-Adrenal Axis: Marked Differences in the Sensitivity to Glucocorticoid Suppression. J Clin Endocrinol Metab. 79:377-383.

245. Riddick L, Chrousos GP, Jeffries S, Pang S. (1994) Comparison of Adrenocorticotropin and Adrenal Steroid Response to Corticotropin Releasing Hormone Versus Metyrapone Testing in Patients with Hypopituitarism. Pediatric Research 36:215-220.

246. Scopa CD, Mastorakos M, Friedman TC, Melachrinou MC, Merino MJ, Chrousos GP. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone (CRH) in Thyroid Lesions. Am J Pathology. 145:1159- 1167.

247. Michelson D, Stone L, Galliven E, Magiakou MA, Chrousos GP, Sternberg EM, Gold PW. (1994) Multiple Sclerosis is Associated with Alterations in Hypothalamic-Pituitary-Adrenal Function. J Clin Endocrinol Metab. 79:848-853.

248. Arai K, Tsigos C, Suzuki Y, Irony I, Karl M, Listwak S, Chrousos GP. (1994) Physiological and Molecular Aspects of Mineralocorticoid Receptor Action in Pseudohypoaldosteronism: A Responsiveness Test and Therapy. J Clin Endocrinol Metab. 79:1019-1023.

249. Mastorakos G, Scopa C, Friedman T, Vryonidou A, Kattis D, Phenekos K, Chrousos GP. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone in Normal and Polycystic Human Ovaries. J Clin Endocrino. Metab. 79:934-939.

250. Mastorakos G, Weber JS, Magiakou MA, Gunn H, Chrousos GP. (1994) Hypothalamic-Pituitary- Adrenal Axis 27

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Activation and Stimulation of Systemic Vasopressin Secretion by Recombinant Interleukin 6 in Humans: Potential Implications for the Syndrome of Inappropriate Vasopressin Secretion. J Clin Endocrinol Metab. 79:1191-1197.

251. Magiakou MA., Mastorakos G, Chrousos GP. (1994) Final Stature in Patients with Endogenous Cushing Syndrome. J Clin Endocrinol Metab. 79:1082-1085.

252. Patchev VK, Brady LS, Karl M, Chrousos GP. (1994) Gene Expression of hsp90 and Glucocorticoid Receptors in the Brain: Evidence for Coordinate Regulation by Adrenal Steroid Levels In Vivo. Cell Mol. Endocrinol. 103:57-64.

253. Stratakis CA, Chrousos GP. (1994) Capillaritis (Purpura Simplex) Associated with Use of Aminoglutethimide in Cushing's Syndrome. Am J Hospital Pharmacy. 51:2589-2591.

254. Beuschlein F, Reincke M, Karl M, Travis WD, Jaursch-Hancke C, Abdelhamid S, Chrousos GP, Allolio B. (1994) Clonal Composition of Human Adrenocortical Neoplasms. Cancer Research. 54:4927-4932.

255. Bernadini R, Chiarenza A, Kamilaris TC, Renaud N, Lempereur L, Demitrack M, Gold PW, Chrousos GP. (1994) In Vivo and In Vitro Effects of Arginine-Vasopressin Receptor Antagonists on the Hypothalamic- Pituitary-Adrenal Axis in the Rat. Neuroendocrinology. 60:503-508.

256. Friedman T, Garcia DB, Hardwick D, Akuete C, Doppman J, Dorn L, Barker C, Chrousos GP. (1994) Decreased Delta Sleep and Plasma Delta Sleep-Inducing Peptide Immunoreactivity in Patients with Cushing Syndrome. Neuroendocrinology. 60:626-634.

257. Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL. (1994) Hypothalamic-Pituitary-Adrenal-Axis Perturbation in Patients with Fibromyalgia. Arthritis and Rheumatism. 37:1583-1592.

258. Michelson D, Chrousos GP, Gold PW. (1994) Type I Glucocorticoid Receptor Blockade Does Not Affect Baseline or Ovine Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropic Hormone and Cortisol Secretion. NeuroImmunoModulation. 1:274-277.

259. Mastorakos G, Cizza G, Kvetnansky R, Bergamini E, Blackman MR, Gold PW, Chrousos GP. (1995) Aging and Acute Stress Decrease Corticotropin Releasing Hormone in the Ovary of the Fischer 344/N Rat. Life Sciences. 56:1065-1071.

260. Latronico A.C., Reincke M., Mendonca B.B., Arai K., Mora P., Allolio B., Wajchenberg B.L., Chrousos, G.P., Tsigos C. (1995) No Evidence for Oncogenic Mutations in the Adrenocorticotropin Receptor (ACTH-R) Gene in Human Adrenocortical Neoplasms. J. Clin. Endocrinol. Metab. 80:875-877.

261. Arai K, Tsigos C, Suzuki Y, Listwak S, Zachman K, Zangeneh F, Rapaport R, Chanoine JP, Chrousos GP. (1995) No Apparent Mineralocorticoid Receptor Defect in a Series of Sporadic Cases of Pseudohypoaldosteronism. J Clin Endocrinol Metab. 80:814-817.

262. Cizza G, Pacak K, Kvetnansky R, Palkovits M, Goldstein DS, Brady LS, Fukuhara K, Bergamini E, Kopin IJ, Blackman MR, Chrousos GP, Gold PW. (1995) Decreased Stress Responsivity of the Central and Peripheral Catecholaminergic Systems in the Aged 344/N Fischer Rat. J Clin Invest. 95:1217-1224.

263. Heinrichs C, Deschepper J, Tsigos C, Drews R, Collu R, Dugardeyn C, Goyens P, Ghanem GE, Bosson D, Chrousos GP, Van Vliet G. (1995) Familial Adrenocorticotropin Unresponsiveness Associated with Alacrima and Achalasia: Biochemical and Molecular Studies in Two Siblings with Clinical Heterogeneity. European J Peds. 154:191-196.

264. Bamberger CM, Bamberger AM, De Castro M, Chrousos GP. (1995) Glucocorticoid Receptor- Beta, a Potential Endogenous Inhibitor of Glucocorticoid Action in Humans. J Clin Invest. 95:2435-2441. 28

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265. Tsigos C, Arai K, Latronico A-C, DiGeorge A, Rapaport R, Chrousos GP. (1995) A Novel Mutation of the Adrenocorticotropin Receptor (ACTH-R) Gene in a Family with the Syndrome of Isolated Glucocorticoid Deficiency but No ACTH-R Abnormalities in Two Families with Triple A Syndrome. J Clin Endocrinol Metab. 80:2186-2189.

266. Mastorakos G, Patchev VK, Chader GJ, Chrousos GP, Gaudet SJ. (1995) Differences in arylakylamine N- Acetyltransferase Activity Between Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats. Neuroendocrinology. 62:71-78.

267. Doppman JL, Nieman LK, Chang R, Yanovski JA, Cutler GB Jr, Chrousos GP, Oldfield EH. (1995) Selective Venous Sampling from the Cavernous Sinuses is not a More Reliable Technique than Sampling from the Inferior Petrosal Sinuses in Cushing Syndrome. J Clin Endocrinol Metab. 80:2485-2489.

268. Karalis K, Crofford L, Wilder RL, Chrousos GP. (1995) Glucocorticoid and/or Glucocorticoid Antagonist Effects in Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats. Endocrinology. 136:3107- 3112.

269. Karalis K, Mastorakos G, Sano H, Davis C, Wilder RL, Chrousos GP. (1995) Somatostatin May Participate in the Antiinflammatory Actions of Glucocorticoids. Endocrinology. 136:4133-4138.

270. Pacak K, McCarty R, Palkovitz M, Cizza G, Kopin IJ, Goldstein D, Chrousos GP. (1995) Decreased Central and Peripheral Catecholaminergic Activation in Obese Zucker Rats. Endocrinology. 136:4360-4367.

271. Mastorakos G, Bouzas E, Caspi R, Friedman T, Chrousos GP. (1995) Immune Corticotropin Releasing Hormone (CRH) is Present in the Eyes of and Promotes Experimental Autoimmune Uveoretinitis (EAU) in Rodents. Endocrinology. 136:4650-4658.

272. Stratakis CA, Mitsiadis NS, Sun D, Chrousos GP, O'Connell A. (1995) Recurring Oral Giant Cell Lesion in X- Linked Hypophosphatemic Rickets: Clinical Manifestation of Occult Hyperparathyroidism? J Pediatrics. 127:444-446.

273. Vgontzas AN, Friedman TC, Chrousos GP, Bixler EO, Vela-Bueno A, Kales A. (1995) Delta Sleep-Inducing Peptide in Normal Humans and in Patients with Sleep Apnea and Narcolepsy. Peptides. 16:1153-1156.

274. Dorn LD, Burgess ES, Dubbert B, Kling M, Gold PW, Chrousos GP. (1995) Psychopathology in Patients with Endogenous Cushing Syndrome: "Atypical" or "Melancholic" Features. Clin Endocrinol (Oxf.) 43:433-442.

275. Cizza G, Gold PW, Chrousos GP. (1995) The Stress-Induced Inhibition of the Hypothalamic- Pituitary-Thyroid Axis is Attenuated in the Aged Fischer 344/N Male Rat. Neuroendocrinology. 62:506-13.

276. Theoharides TC, Spanos C, Pang Z, Alferes L, Ligris K, Letourneau R, Rozniecki JJ, Webster E, Chrousos GP. (1995) Stress-Induced Intracranial Mast Cell Degranulation. A Corticotropin-Releasing Hormone-Mediated Effect. Endocrinology. 136:5745-50.

277. Yanovski JA, Yanovski SZ, Harrington L, Gold P, Chrousos GP. (1995) Differences in the Hypothalamic- Pituitary-Adrenal Axis of Black and White Men. Hormone Research. 44:208-212.

278. Chen H, Doppman JL, Chrousos GP, Norton JA, Nieman LK, Udelsman R. (1995) ACTH- Secreting Pheochromocytomas: The Exception to the Rule. Surgery. 118:988-995.

279. Yu KC, Alexander HR, Ziessman HA, Norton JA, Buell JF, Nieman LK, Cutler Jr GB, Chrousos GP, Fraker D.L. (1995) The Role of Pre-Operative Iodocholesterol Scintiscanning in Patients Undergoing Adrenalectomy for Cushing's Syndrome. Surgery. 118:981-987.

280. Amikura K, Alexander RH, Norton JA, Doppman JL, Jensen RT, Nieman LK, Cutler GB, Chrousos GP, Fraker 29

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DL. (1995) The Role of Surgery in Management of ACTH-Producing Islet Cell Tumors of the Pancreas. Surgery. 118:1125-1130.

281. Kawahito Y., Sano H., Mukai S., Asai K., Kimura S., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo M. (1995) Corticotropin Releasing Hormone in Colonic Mucosa in Patients with Ulcerative Colitis. GUT 37:544-551.

282. Stratakis CA, Carney A, Ping J, Papanicolaou DA, Karl M, Kastner DL, Pras E, Chrousos GP. (1996) Carney Complex, a Familial Multiple Neoplasia and Lentiginosis Syndrome: Analysis of 11 Kindreds and Linkage to the Short Arm of Chromosome 2. J Clin Invest. 97:699-705.

283. Karl M, Von Wichert G, Kempter E, Katz DA, Reincke M, Monig H, Ali IU, Stratakis CA, Oldfield EH, Chrousos GP, Schulte HM. (1996) Nelson's Syndrome Associated with a Somatic Frame Shift Mutation in the Glucocorticoid Receptor Gene. J Clin Endocrinol Metab. 81:124-129.

284. Ghizzoni L, Mastorakos G, Vottero A, Magiakou MA, Chrousos GP, Bernasconi S. (1996) Spontaneous Cortisol and Growth Hormone Secretion Interactions in Patients with Nonclassic 21-Hydroxylase Deficiency (NCCAH) and Control Children. J Clin Endocrinol Metab. 81:482-487.

285. Latronico AC, Anasti J, Arnhold IJP, Rapaport R, Mendonca BB, Bloise W, de Castro M, Tsigos G, Chrousos GP. (1996) Testicular and Ovarian Resistance to Luteinizing Hormone Caused by Homozygous Inactivating Mutations of the Luteinizing Hormone Receptor Gene. N Engl J Med. 334:507-512.

286. Johnson EO, Decker L, Gold PW, Chrousos GP. (1996) Distribution of Hippocampal Mineralocorticoid and Glucocorticoid Receptor mRNA in a Glucocorticoid Resistant Nonhuman Primate. Steroids. 61:69-73.

287. Petzke F, Heppner C, Mbulamberi D, Winkelmann W, Chrousos GP, Allolio B, Reincke M. (1996) Hypogonadism in Rhodesian Sleeping Sickness: Evidence for Acute and Chronic Dysfunction of the Hypothalamic-Pituitary-Gonadal Axis. Fertility and Sterility. 65:68-75.

288. Mastorakos G, Scopa CD, Kao LC, Vryonidou A, Friedman TC, Kattis D, Phenekos C, Rabin D, Chrousos GP. (1996) Presence of Immunoreactive Corticotropin Releasing-Hormone (CRH) in Human Endometrium. J Clin Endocrinol Metab. 81:1046-1050.

289. Dorn LD, Burgess ES, Dichek HL, Putnam F, Chrousos GP, Gold PW. (1996) Thyroid Hormone Concentrations in Depressed and Non-Depressed Adolescents: Group Differences and Behavioral Relations. J. Am. Acad. Child Adolesc. Psychiatry. 35:299-306.

290. Leong GM, Mercado-Asis, LB, Reynolds JC, Oldfield EH, Chrousos GP. (1996) The Effect of Cushing Disease on Bone Mineral Density, Body Composition, Growth and Puberty: A Report of an Identical Adolescent Twin Pair. J Clin Endocrinol Metab. 81:1905-1911.

291. Magiakou MA, Mastorakos G, Rabin D, Dubbert B, Gold PW, Chrousos, GP. (1996) Hypothalamic Corticotropin Releasing Hormone Suppression during the Postpartum Period: Implications for the Increase of Psychiatric Manifestations during this Time. J Clin Endocrinol Metab. 81:1912-1917.

292. Karl M, Saviolakis GA, Gravanis A, Chrousos GP, Margioris AN. (1996) The PC 12 Rat Pheochromocytoma Cell Line Expresses the Prodynorphin Gene and Secretes the 8 kdalton Dynorphin Product. Regulatory Peptides. 61:99-104.

293. Magiakou MA, Mastorakos G, Rabin D, Margioris AN, Dubbert B, Calogero AE, Tsigos C, Munson PJ, Chrousos GP. (1996) The Maternal Hypothalamic-Pituitary-Adrenal Axis in Third Trimester Human Pregnancy. Clin Endocrinol (Oxf.) 44:419-428.

294. Kalogeras KT, Nieman LK, Friedman TC, Dopppman JL, Cutler GB Jr, Chrousos GP, Wilder RL, Gold PW, Yanovski JA. (1996) Inferior Petrosal Sinus Sampling in Normal Human Subjects Reveals a Unilateral 30

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Corticotropin-Releasing Hormone-Induced Arginine Vasopressin Release Associated with Ipsilateral Adrenal Corticotropin Secretion. J Clin Invest. 97:2045-2050.

295. Johnson EO, Kamilaris TC, Calogero AE, Gold PW, Chrousos GP. (1996) Effects of Early Parenting on Growth and Development in a Small Primate. Pediatric Research. 39:999-1005.

296. Papanicolaou DA, Tsigos, C, Oldfield EH, Chrousos GP. (1996) Acute Glucocorticoid Deficiency is Associated with Plasma Elevation of Interleukin-6: Does the Latter Participate in the Symptomatology of the Steroid Withdrawal Syndrome and Adrenal Insufficiency? J Clin Endocrinol Metab. 81:2303-2306.

297. Dorn LD, Burgess ES, Susman EJ, Von Eye A, DeBellis MD, Gold PW, Chrousos GP. (1996) Response to Ovine Corticotropin Releasing Hormone in Depressed and Nondepressed Adolescents: Does Gender Make a Difference? J Am Acad Child Adolesc Psychiatry. 35:764-773.

298. Burgess ES, Dorn LD, Haaga D, Chrousos GP. (1996) Sociotropy, Autonomy, Stress and Depression in Cushing Syndrome. J Nerv Ment Dis. 184:362-367.

299. Karl M, Lamberts SWJ, Koper JW, Katz DA, Huizenga NE, Kino T, Haddad BR, Hughes MR, Chrousos GP. (1996) Cushing's Disease Preceded by Generalized Glucocorticoid Resistance: Clinical Consequences of a Novel, Dominant-negative Glucocorticoid Receptor Mutation. Proc Assn Amer Phys. 108:296-307.

300. Friedman TC, Nieman, LK, Yanovski JA, Doppman JL, Cutler GB Jr, Oldfield EH, Gold, PW, Chrousos GP, Kalogeras KT. (1996) Inferior Petrosal Sinus Arginine Vasopressin Concentrations in Normal Volunteers and Patients with Cushing Disease. J Clin Endocrinol Metab. 81:3068-3072.

301. Yanovski JA, Zelitch-Yanovski SA, Friedman TC, Loh Peng Y, Jayasvasti V, Cutler GB Jr, Chrousos GP. (1996) Etiology of the Differences in Corticotropin-Releasing Hormone-Induced ACTH Secretion of Black and White Women. J Clin Endocrinol Metab. 81:3307-3311.

302. Makrigiannakis A, Zoumakis E, Margioris AN, Stournaras C, Chrousos GP, Gravanis A. (1996) Regulation of the Promoter of the Human Corticotropin-Releasing Hormone (CRH) Gene in Transfected Human Endometrial Cells. Neuroendocrinology. 64:85-92.

303. DeMarco L, Stratakis CA, Boson WL, Jakbovitz O, Carson E, Andrade LM, Amaral VF, Rocha JL, Chrousos GP, Nordenskjöld M, Friedman E. (1996) Sporadic Cardiac Myxomas and Tumors from Patients with Carney Complex are not Associated with Activating Mutations of the Gs Gene. Hum Genet. 98:185-188.

304. Papanicolaou DA, Petrides JS, Tsigos C, Bina S, Kalogeras KT, Wilder R, Gold PW, Deuster PA, Chrousos GP. (1996) Exercise Stimulates Interleukin-6 Secretion: Inhibition By Glucocorticoids and Correlation With Catecholamines. Am J Physiol. E601-E605.

305. Johnson EO, Kamilaris TC, Carter CS, Calogero AE, Gold PW, Chrousos GP. (1996) The Biobehavioral Consequences of Psychogenic Stress in a Small, Social Primate (Callithrix jacchus jacchus). Biol Psychiatry. 40:317-337.

306. Castro M, Elliot S, Kino T, Bamberger C, Karl M, Webster E, Chrousos GP. (1996) The Nonligand Binding - Isoform of the Human Glucocorticoid Receptor (hGR): Tissue Levels, Mechanism of Action and Potential Physiologic Role. Mol Med. 2:597-607.

307. Yanovski JA, Yanovski SZ, Cutler GB Jr, Chrousos GP, Filmer K. (1996) Differences in the Hypothalamic- Pituitary-Adrenal Axis of African American and Caucasian Girls. J Pediatrics. 129:130-136.

308. Cizza G, Nieman LK, Doppman JL, Passaro MD, Czerwiec FS, Chrousos GP, Cutler GB Jr. (1996) Factitious Cushing Syndrome. J Clin Endocrinol Metab. 81:3573-3577.

309. Stratakis CA, Jenkins RB, Pras E, Mitsiadis CS, Raff SB, Stalboerger PG, Tsigos C, Carney A, Chrousos GP. 31

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(1996) Cytogenetic and Mircosatellite Alterations in Tumors from Patients with the Syndrome of Myxomas, Spotty Skin Pigmentation, and Endocrine Overactivity (Carney Complex). J Clin Endocrinol Metab. 81:3607- 3614.

310. Reincke M, Wachenfeld C, Mora P, Thumser A, Jaursch-Hancke C, Abdelhamid S, Chrousos GP, Allolio B. (1996) p53 Mutations in Adrenal Tumors: Caucasian Patients Do Not Show the Exon 4 "Hot Spot" Found in Taiwan. J Clin Endocrinol Metab. 81:3636-3638.

311. Michelson D, Stratakis C, Hill LY, Reynolds J, Galliven, E, Chrousos, GP, Gold, PW. (1996) Bone Mineral Density is Decreased in Women With Depression. N Engl J Med. 335:1176-1181.

312. Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP. (1996) Modulatory Effects of Glucocorticoids and Catecholamines on Human Interleukin-12 and Interleukin-10 Production: Clinical Implications. Proc Assn Am. Phys. 108:374-381.

313. Stratakis CA, Chrousos GP. (1996) Transient Elevation of Serum Thyroid Hormone Levels Following Lithium Discontinuation. Eur J Peds. 155:939-941.

314. Wong M, Ramayya MS, Chrousos GP, Driggers PH, Parker KL. (1996) Cloning and Sequencing Analysis of the Human Gene Encoding Steroidogenic Factor 1. J Mol Endocrinol. 17:139-147.

315. Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP. (1996) In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation. Endocrinology. 137:5747-5750.

316. Cizza G, Brady LS, Esclapes M, Blackman MR, Gold PW, Chrousos GP. (1996) Age and Gender Influence Basal and Stress-Modulated Hypothalamic-Pituitary-Thyroidal Function in Fischer 344/N Rats. Neuroendocrinology. 64:440-448.

317. Stratakis CA, Orban Z, Burns AL, Vottero A, Mitsiades CS, Marx SJ, Abbassi V, Chrousos GP. (1996) Dideoxyfingerprinting (ddF) Analysis of the Type X Collagen Gene (COL10A1) and Identification of a Novel Mutation (S671P) in a Kindred with Schmid Metaphyseal Chondrodysplasia. Biochem Mol Med. 59:112-117.

318. Friedman TC, Mastorakos G, Newman TD, Mullen NM, Horton EG, Costello R, Papadopoulos NM, Chrousos GP. (1996) Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism: Shared Features with Metabolic Syndrome X and Noninsulin-Dependent Diabetes Mellitus. Endocrine Journal. 43:645-656.

319. Stratakis CA, Mitsiades NS, Chrousos GP Receptor- and Opioid Type-Specific Manner. Eur J Pharmacol. 315:53-58.

320. Oberfield SE, Nirenberg A, Allen JC, Cohen H, Donahue B, Prasad V, Schiff R, Pang S, Ghavimi F, David, Chrousos GP, Sklar C. (1997) Hypothalamic-Pituitary-Adrenal Function Following Cranial Irradiation. Horm Res. 47:9-16.

321. Susman E, Dorn L, Inoff-Germain G, Nottelmann E, Chrousos GP. (1997) Cortisol Reactivity, Distress Behavior, and Behavioral and Psychological Problems in Young Adolescents: A Longitudinal Perspective. J Res Adolescence. 7:81-105.

322. Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP. (1997) The Longitudinal Course of Psychopathology in Cushing Syndrome After Correction of Hypercortisolism. J Clin Endocrinol Metab. 82:912-919.

323. Sarlis NJ, Chrousos GP, Doppman JL, Carney JA, Stratakis CA. (1997) Primary Pigmented Nodular Adrenocortical Disease: Reevaluation of a Patient with Carney Complex 27 Years After Unilateral Adrenalectomy. J Clin Endocrinol Metab. 82:1274-1278.

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324. Crofford LJ, Kalogeras KT, Mastorakos G, Magiakou M-A, Wells J, Kanik KS, Gold PW, Chrousos GP, Wilder RL. (1997) Circadian Relationships Between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis. J Clin Endocrinol Metab. 82:1279-1283.

325. Licinio J, Mantzoros C, Negrão AB, Cizza G, Wong M-L, Bongiorno PB, Chrousos GP, Karp B, Ellen C, Flier JS, Gold PW. (1997) Human Leptin Levels are Pulsatile and Inversely Related to Pituitary-Adrenal Function. Nature Medicine. 3:575-579.

326. Taymans SE, DeVries AC, DeVries MB, Nelson RJ, Friedman TC, Castro M, Detera-Wadleigh S, Carter CS, Chrousos GP. (1997) The Prairie Vole (Microtus ochrogaster) as a Model of Glucocorticoid Resistance. Gen Comp Endocrinol. 106:48-61.

327. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. (1997) Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity. J Clin Endocrinol Metab. 82:1313-1316.

328. Magiakou MA, Mastorakos G, Zachman K, Chrousos GP. (1997) Blood Pressure in Children and Adolescents with Cushing Syndrome Before and After Surgical Cure. J Clin Endocrinol Metab. 82:1734-1738.

329. Ramayya MS, Zhou J, Kino T, Segars JH, Bondy CA, Chrousos GP. (1997) Steroidogenic Factor-1 (hSF-1) mRNA Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and In Situ Hybridization Studies. J Clin Endocrinol Metab. 82:1799-1806.

330. Yanovski JA, Yanovski SZ, Gold PW, Chrousos GP. (1997) Differences in Corticotropin- Releasing Hormone- Stimulated Adrenocorticotropin and Cortisol Before and After Weight Loss. J Clin Endocrinol Metab. 82:1874-1878.

331. de Lange P, Koper JW, Huizenga NATM, Brinkman AO, de Jong FH, Cato ACB, Karl M, Chrousos GP, Lamberts SWJ. (1997) Differential Hormone-Dependent Transactivation and Transrepression by Naturally Occurring Human Glucocorticoid Receptor (GR) Variants. Mol Endocrinol. 11:1156-1164

332. Premkumar A, Stratakis CA, Shawker TH, Papanicolaou DA, Chrousos GP. (1997) Testicular Ultrasound in Carney Complex: Report of Three Cases. J Clin Ultrasound. 25:211-214.

333. Petrides JS, Gold PW, Mueller GP, Singh A, Stratakis CA, Chrousos GP, Deuster PA. (1997) Marked Differences in Functioning of the Hypothalamic-Pituitary-Adrenal Axis Between Groups of Men. J Appl Physiol. 82:1979-1988.

334. Reincke M, Beuschlein F, Latronico A-C, Arlt W, Chrousos GP, Allolio B. (1997) Expression of Adrenocorticotrophic Hormone Receptor mRNA in Human Adrenocortical Neoplasms: Correlation with P450scc Expression. Clin Endocrinol. (Oxford) 46:619-626.

335. Michelson D, Galliven E, Hill L, Demitrack M, Chrousos GP, Gold P. (1997) Chronic Imipramine is Associated with Diminished Hypothalamic-Pituitary-Adrenal Axis Responsivity in Healthy Humans. J Clin Endocrinol Metab. 82:2601-2606.

336. Cizza G, Lotsikas AJ, Licinio J, Gold PW, Chrousos GP. (1997) Plasma Leptin Levels Do Not Change in Patients with Cushing‟s Disease Shortly After Correction of Hypercortisolism. J Clin Endocrinol Metab. 82:2747-2750.

337. Tsigos C, Papanicolaou DA, Defensor R, Mitsiades CS, Kyrou I, Chrousos GP. (1997) Dose Effects of Recombinant Human Interleukin-6 on Piuitary Hormone Secretion and Energy Expenditure. Neuroendocrinology. 66:54-62.

338. Bamberger CM, Bamberger A, Wald M, Chrousos GP, Schulte HM. (1997) Inhibition of Mineralocorticoid 33

George P. Chrousos, M.D.

Activity by the -Isoform of the Human Glucocorticoid Receptor. J Steroid Biochem and Mol Biol. 60:43-50.

339. Arnold IJP, Latronico AC, Batista MC, Carvalho FM, Chrousos GP, Mendonca BB. (1997) Ovarian Resistance to Luteinizing Hormone: A Novel Cause of Amenorrhea and Infertility. Fertil Steril. 67:394-397.

340. Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos GP, Allolio B. (1997) Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis. J Clin Endocrinol Metab. 82:3054-3058.

341. Vgontzas AN, Bixler EO, Papanicolaou DA, Kales A, Stratakis CA, Vela-Bueno A, Gold PW, Chrousos GP. (1997) REM Sleep Correlates with the Overall Activities of the Hypothalamic- Pituitary-Adrenal (HPA) Axis and Sympathetic System in Healthy Humans. J Clin Endocrinol Metab. 82:3278-3280.

342. Ghizzoni L, Mastorakos G, Vottero A, Bareca A, Furlini M, Cesarone A, Ferrari B, Chrousos GP, Bernasconi S. (1997) Corticotropin-Releasing Hormone (CRH) Inhibits Steroid Biosynthesis by Cultured Human Granulosa-Lutein Cells in a CRH and Interleukin-1 Receptor -Mediated Fashion. Endocrinology. 138:4806- 4811.

343. Yanovski JA, Friedman TC, Nieman LK, Chrousos GP, Cutler GB Jr, Doppman JL, Kalogeras KT. (1997) Inferior Petrosal Sinus AVP in Patients with Cushing‟s Syndrome. Clin Endocrinol. 47:199-206.

344. Stratakis CA, Sarlis NJ, Berrettini WH, Badner JA, Chrousos GP, Gershon ES, Detera-Wadleigh SD. (1997) Lack of Linkage Between the Corticotropin-Releasing Hormone (CRH) Gene and Bipolar Affective Disorder. Mol Psychiatry. 2:483-485.

345. Ghizzoni L, Mastorakos G, Street ME, Vottero A, Mazzardo G, Vanelli M, Chrousos GP, Bernasconi S. (1997) Spontaneous Thyrotropin and Cortisol Secretion Interactions in Patients with Nonclassical 21- Hydroxylase Deficiency and Control Children. J Clin Endocrinol Metab. 82:3677-3683.

346. Leung DYM, Hamid Q, Vottero A, Szefler SJ, Surs W, Minshall E, Chrousos GP, Klemm DJ. (1997) Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor. J Exp Med. 186:1567-1574.

347. Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis CS, Chrousos GP. (1997) Dose- Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation. J Clin Endocrinol Metab. 82:4167-4170.

348. Stratakis C, Magiakou MA, Mastorakos G, Oldfield E, Chrousos GP. (1997) Thyroid Function in Children with Cushing Disease Before and After Transsphenoidal Surgery. J Peds. 131:905-909.

349. Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E, Chrousos GP. (1998) Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects. Endocrinology. 139:403-413.

350. Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrão AB, Gold PW, Chrousos GP. (1998) Plasma Leptin Levels Are Increased in Survivors of Acute Stress: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion. J Clin Endocrinol Metab. 88:280-283.

351. Yanovski JA, Cutler GB, Chrousos GP, Nieman LK. (1998) The Dexamethasone-Suppressed Corticotropin- Releasing Hormone Stimulation Test Differentiates Mild Cushing‟s Disease from Normal Physiology. J Clin Endocrinol Metab. 83:348-352.

352. Papanicolaou DA, Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. (1998) A Single Midnight Serum Cortisol Measurement Distinguishes Cushing‟s Syndrome from Pseudo-Cushing States. J Clin Endocrinol Metab. 83:1163-1167.

353. Stratakis CA, Vottero A, Brodie A, Kirschner LS, DeAtkine D, Lu Q, Yue W, Mitsiades CS, Flor AW, 34

George P. Chrousos, M.D.

Chrousos GP. (1998) The Aromatase Excess Syndrome is Associated with Feminization of Both Sexes and Autosomal Dominant Transmission of Aberrant P450arom Gene Transcription. J Clin Endocrinol Metab. 83:1348-1357.

354. Bornstein SR, Webster EL, Torpy DJ, Richman SJ, Mitsiades N, Igel M, Lewis DB, Rice KC, Joost HG, Tsokos M, Chrousos GP. (1998) Chronic Effects of a Nonpeptide Corticotropin- Releasing Hormone Type 1- Receptor Antagonist on Pituitary-Adrenal Function, and Body Weight and Metabolic Regulation. Endocrinology. 139:1546-1555.

355. Yanovski JA, Nieman LK, Doppman JL, Chrousos GP, Wilder RL, Gold PW, Kalogeras KT. (1998) Plasma Levels of Corticotropin-Releasing Hormone in the Inferior Petrosal Sinuses of Healthy Volunteers, Patients with Cushing‟s Syndrome, and Patients with Pseudo-Cushing States. J Clin Endocrinol Metab. 83:1485-1488.

356. Gragerov A, Kino T, Ilyina-Gragerova G, Chrousos GP, Pavlakis GN. (1998) HHR23A, the Human Homologue of the Yeast Repair Protein RAD23 Interacts Specifically with Vpr Protein and Prevents Cell Cycle Arrest But Not the Transcriptional Effects of Vpr. Virology. 245:323-330.

357. Stratakis CA, Mastorakos G, Mitsiades NS, Mitsiades CS, Chrousos GP. (1998) Skin Manifestations of Cushing Disease in Children and Adolescents Before and After the Resolution of Hypercortisolemia. Ped Dermatol. 15:253-258.

358. Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR. (1998) Aberrant Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing‟s Syndrome. N Engl J Med. 339:27-31.

359. Vgontzas AN, Tsigos C, Kales A, Stratakis CA, Zachman K, Bixler eO, Velo-Bueno A, Chrousos GP. (1998) Chronic Insomnia and Activity of the Stress System: A Preliminary Study. J Psychosomatic Res. 45:21-31.

360. Elenkov IJ, Webster EL, Papanicolaou DA, Fleisher TA, Chrousos GP, Wilder RL. (1998) Histamine Potently Suppresses Human Interleukin-12 and Stimulates Interleukin-10 Production via H2 Receptors. J Immunol. 161:2586-2593.

361. Torpy DJ, Gordon RD, Lin J-P, Huggard PR, Taymans SE, Stowasser M, Chrousos GP, Stratakis CA. (1998) Familial Hyperaldosteronism Type-II: Description of a Large Kindred and Exclusion of the Aldosterone Synthase (CYP11B2) Gene. J Clin Endocrinol Metab. 83:3214-3218.

362. Torpy DJ, Tsigos C, Lotsikas AJ, Defensor R, Chrousos GP, Papanicolaou DA. (1998) Acute and Delayed Effects of a Single-Dose Injection of Interleukin-6 on Thyroid Function in Healthy Humans. Metabolism. 47:1289-1293.

363. Chan EC, Falconer J, Madsen G, Read M, Chrousos GP, Webster EL, Rice K, Smith RA. (1998) Corticotropin- Releasing Hormone Type I Receptor Antagonist Delays Parturition in Sheep. Endocrinology. 139:3357-3360.

364. Longui CA, Vottero A, Harris AG, Chrousos GP. (1998) Plasma Cortisol Responses After Intramuscular ACTH 1-24 in Healthy Men. Metabolism. 47:1419-1422.

365. Glasow A, Haidan A, Hilbers U, Breidert M, Gillespie J, Scherbaum WA, Chrousos GP, Bornstein SR. (1998) Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and Adrenomedullary Function by Leptin. J Clin Endocrinol Metab. 83:4459-4466.

366. Torpy DJ, Bornstein SR, Chrousos GP. (1998) Leptin and Interleukin-6 in Sepsis. Horm Metab Res. 30:726- 729.

367. Willenberg HS Bornstein SR, Dumser T, Ehrhart-Bornstein M, Barocka A, Chrousos GP, Scherbaum WA. (1998) Morphological Changes in Adrenals From Victims of Suicide in Relation to Altered Apoptosis. Endocrine Research. 24:963-967. 35

George P. Chrousos, M.D.

368. Deuster PA, Petrides JS, Singh A, Lucci EG, Chrousos GP, Gold PW. (1998) High Intensity Exercise Promotes Escape of ACTH and Cortisol From Suppression by Dexamethasone: Sexually Dimorphic Responses. J Clin Endocrinol Metab. 83:3332-3338.

369. Kino T, Gragerov A, Kopp JB, Stauber RH, Pavlakis GN, Chrousos GP. (1999) The HIV-1 Virion-associated Protein Vpr is a Coactivator of the Human Glucocorticoid Receptor. J Exp Med. 89:51-61.

370. Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF, Licinio J, Wong M-L, Chrousos GP, Webster E, Gold PW. (1999) The Impact of the Nonpeptide CRH Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress. Endocrinology. 140:79-86.

371. Heino M, Scott HS, Chen Q, Peterson P, Maenpaa U, Papasavvas MP, Mittaz L, Barras C, Rossier C, Chrousos GP, Stratakis CA, Nagamine K, Kudoh J, Shimizu N, Maclaren N, Antonarakis SE, Krohn K. (1999) Mutation Analyses of North American APS-1 Patients. Human Mutation. 13: 69-74.

372. Shahidi H, Vottero A, Stratakis CA, Taymans SE, Karl M, Longui CA, Chrousos GP, Daughaday WH, Gregory SA, Plate JMD. (1999) Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. Biochem Biophys Res Commun. 254:559-565.

373. Vottero A, Stratakis CA, Ghizzoni L, Longui CA, Karl M, Chrousos GP. (1999) Androgen receptor- mediated Hypersensitivity to Androgens in Women with Nonhyperandrogenic Hirsutism: Skewing of X-chromosome Inactivation. J Clin Endocrinol Metab. 84:1091-1095.

374. Tataranni PA, Cizza G, Snitker S, Gucciardo F, Lotsikas A, Chrousos GP, Ravussin E. (1999) Hypothalamic- pituitary-adrenal Axis and Sympathetic Nervous System Activities in Pima Indians and Caucasians. Metabolism. 48:395-399.

375. Torpy DJ, Chen C, Mullen N, Doppman JL, Carrasquillo J, Chrousos GP, Nieman LK. (1999) Lack of Utility of 111In-Pentetreotide Scintigraphy in Localizing Ectopic ACTH Producing Tumors: Follow-up of 18 Patients. J Clin Endocrinol Metab. 84:1186-1192.

376. Singh A, Papanicolaou DA, Lawrence LL, Howell EA, Chrousos GP, Deuster PA. (1999) Neuroendocrine Responses to Exhaustive Running in Women. Med Sci Sports Exerc. 31:536-542.

377. Torpy DJ, Webster EL, Zachman EK, Aguilera G, Chrousos GP. (1999) Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation. Neuroimmunomodulation. 6:182-186.

378. Susman EJ, Schmeelk KH, Worrall BK, Granger DA, Ponirakis A, Chrousos GP. (1999) Corticotropin Releasing Hormone and Cortisol: Longitudinal Associations with Depression and Antisocial Behavior in Pregnant Adolescents. J Amer Acad Chid and Adol Psychiatry. 38:460-467.

379. Bottner A, Eisenhofer G, Torpy DJ, Ehrhart-Bornstein M, Keiser HR, Chrousos GP, Bornstein SR. (1999) Lack of Leptin Suppression in Response to Hypersecretion of Catecholamines in Pheochromocytoma Patients. (Preliminary Report) Metabolism. 48:543-545.

380. Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte J-J, Chrousos GP, Szefler SJ, Leung DYM. (1999) Increased Glucocorticoid Receptor-beta in Airway Cells of Glucocorticoid- insensitive Asthma. Am J Respir Crit Care Med. 159:1600-1604.

381. Dorn LD, Nottelmann E, Susman EJ, Inoff-Germain G, Cutler GB Jr, Chrousos GP. (1999) Variability in Hormone Concentrations and Self-reported Menstrual Histories in Young Adolescents: Menarche as an Integral Part of a Developmental Process. J Youth & Adolescence. 28:283-303.

382. Yanovski JA, Miller KD, Kino T, Friedman TC, Chrousos GP, Tsigos C, Falloon J. (1999) Endocrine and 36

George P. Chrousos, M.D.

Metabolic Evaluation of HIV-infected Patients with Evidence of Protease Inhibitor Associated Lipodystrophy. J Clin Endocrinol Metab. 84:1925-1931.

383. Orban Z, Remaley AT, Sampson M, Trajanoski Z, Chrousos GP. (1999) the Differential Effect of Food Intake and -Adrenergic Stimulation of Adipose-Derived Hormones and Cytokines in Man. J Clin Endocrinol Metab. 84:2126-2133.

384. Singh A, Petrides JS, Gold PW, Chrousos GP, Deuster PA. (1999) Differential Hypothalamic-Pituitary- Adrenal Axis Reactivity to Psychological and Physical Stress. J Clin Endocrinol. 84:1944-1948.

385. Schmeelk KH, Granger DA, Susman EJ, Chrousos GP. (1999) Maternal Depression and Risk for Postpartum Complications in Adolescents: Role of Prenatal Corticotrophin-releasing Hormone and Interleukin-1 Receptor Antagonist. Behaviorial Medicine. 25:88-94.

386. Arai K, Zachman K, Shibasaki T, Chrousos GP. (1999) Polymorphisms of Amiloride Sensitive Sodium Channel Subunits in Five Sporadic Cases of Pseudohypoaldosteronism: Do They Have Pathologic Potential? J Clin Endocrinol Metab. 84:2434-2437.

387. Franchimont D, Louis E, Dupont P, Vrindts-Gevaert Y, Dewe W, Chrousos GP, Geenen V, Belaiche J. (1999) Decreased Corticosensitivity in Quiescent Crohn‟s Disease An Ex Vivo Study Using Whole Blood Cell Cultures, Digestive Diseases and Sciences. 44:1208-1215.

388. Wong M, Webster EL, Spokes H, Phu P, Ehrhart-Bornstein M, Bornstein S, Park C, Rice KC, Chrousos GP, Licinio J, Gold PW. (1999) Chronic Administration of the Non-Peptide CRH Type 1 Receptor Antagonist Antalarmin Does Not Blunt Hypothalamic-Pituitary-Adrenal Axis Responses to Acute Immobilization Stress. Life Sciences. 65:53-58.

389. Franchimont D, Martens H, Habelstein M, Louis E, Dewe W, Chrousos GP, Belaiche J, Geenen V. (1999) Tumor Necrosis Factor Decreases, and Interleukin-10 Increases, the Sensitivity of Human Monocytes to Dexamethasone: Potential Regulation of the Glucocorticoid Receptor. J Clinical Endocrinology & Metabolism. 84:2834-2839.

390. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong M, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP. (1999) Circadian Interleukin-6 Secretion and Quality and Depth of Sleep. J Clinical Endocrinology & Metabolism. 84:2603-2607.

391. Vgontzas AN, Mastorakos G, Bixler EO, Kales A, Gold PW, Chrousos GP. (1999) Sleep Deprivation Effects on the Activity of the Hypothalamic-Pituitary-Adrenal and Growth Axes: Potential Clinical Implications. Clinical Endocrinol. (Oxf.) 51:205-215.

392. Macrigiannakis A, Margioris A, Chrousos GP, Stounaras C, Gravanis A, (1999) The Decidualizing Effect of Progesterone May Involve Direct Transcriptional Activation of Corticotropin Releasing Hormone (CRH) from Human Endometrial Stroma Cells. Molecular Human Reproduction. 5:789-796.

393. Kino T, Nordeen SK, Chrousos GP. (1999) Conditional Modulation of Glucocorticoid Receptor Activities by CREB-binding Protein (CBP) and p300. J Steroid Biochem Molec Biol. 70:15-25.

394. Stratakis CA, Sarlis N, Kirschner LS, Carney JA, Doppman JL, Nieman LK, Chrousos GP, Papanicolaou D. A.(1999) Paradoxic Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease. Ann Intern Med. 131:585-591.

395. Wolkersdorfer GW, Lohmann T, Schroder S, Marx C, Pfeiffer R, Stahl H-D, Chrousos GP, Bornstein SR, (1999) Lymphocytes Stimulate Dehydroepiandrosterone Production Through Direct Cellular Contact with Adrenal Zona Reticularis Cells: A Novel Mechanism of Immune-Endocrine Interaction. J Clin Endocrinol Metab. 84:4220-4227.

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396. Koch CA, Azumi N, Furlong MA, Jha RC, Kehoe TE, Trowbridge CH, O‟Dorisio TM, Chrousos GP. (1999) Clement SC. CLINICAL CASE SEMINAR: Carcinoid Syndrome Caused by an Atypical Carcinoid of the Uterine Cervix. J Clin Endocrinol Metab. 84:4208-4213.

397. Torpy DJ, Webster EL, Zachman EK, Aguilera G, Chrousos GP. (1999) Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation. Neuroimmunomodulation. 6:182-186.

398. Tsigos C, Papanicolaou D, Kyrou I, Chrousos GP. (1999) Dose Effects of Recombinant Human Interleukin-6 on the Pituitary-testicular Axis. J Interferon and Cytokine Res. 19:1271-6.

399. Link AA, Kino T , Worth JA, McGuire JL, Crane ML, Chrousos GP, Wilder RL, Elenkov IJ. (2000) Ligand- Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes. J Immunology. 164:436-442.

400. Orban Z, Mitsiades N, Burke Jr TR, Tsokos M, Chrousos GP. (2000) Caffeic Acid Phenethyl Ester Induces Leukocyte Apoptosis, Modulates Nuclear Factor-Kappa B and Suppresses Acute Inflammation. Neuroimmunomodulation. 7:99-105.

401. Wong M-L, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, Karp B, McCutcheon IE, Geracioti Jr. TD, DeBellis MD, Rice KC, Goldstein DS, Veldhuis JD, Chrousos GP, Oldfield EH, McCann SM, Gold PW. (2000) Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with Melancholic Features: Relation to Hypercortisolism and Corticotropin Releasing Hormone. Proc Natl Acad Sci USA. 97:325-330.

402. Franchimont D, Galon J, Gadina M, Visconti R, Zhou Y, Aringer M, Frucht DM, Chrousos GP, O‟Shea JJ, (2000) Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12- induced Stat-4 Phosphorylation in T Lymphocytes. J Immunol. 164(4):1768-74.

403. Kanik S, Chrousos GP, Schumacher HR, Crane ML, Yarboro CH, Wilder RL. (2000) ACTH, Glucocorticoid and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of Inflammation, J Clinical Endocrinol Metab. 85:1461-1466

404. Vgontzas AN, Papanicolaou D A, Bixler EO, Hopper K, Lotsikas A, Kales A, Chrousos GP. (2000), Sleep Apnea and Daytime Sleepiness and Fatigue: Relations With Visceral Obesity, Insulin Resistance, and Hypercytokinemia. J Clin Endocrinol Metab. 85:1151-1158.

405. Pathomvanich A, Merke DP, Chrousos GP. (2000) Early Puberty: A Cautionary Tale (Commentary). Pediatrics. 105:115-116.

406. Torpy DJ, Papanicolaou DA, Lotsikas AJ, Wilder RL, Chrousos GP, Pillemer SR, (2000) Responses of the Sympathetic Nervous System and the Hypothalamic-Putuitary-Adrenal Axis to Interleukin-6 in fibromyalgia. Arthritis & Rheumatism. 43(4):872-880.

407. Deuster PA, Petrides JS, Singh A, Chrousos GP, Poth ML. (2000) Endocrine Response to High-Intensity Exercise: Dose-Dependent Effects of Dexamethasone. J of Clinical Endocrinology and Metab. 85:1066-1073.

408. Hsin L-W, Webster EL, Chrousos GP, Gold PW, Eckelman WC, Contoreggi C, Rice KC. (2000) Synthesis and Biological Activity of Fluoro-Substituted Pyrrolo [2,3-d]pyrimidines: the Development of Potential Positron Emission Tomography Imaging Agents for Corticotropin- Releasing Hormone type 1 Receptor. Bioorganic & Medicinal Chemistry Letters. 10:707-710.

409. Kanik KS, Chrousos GP, Schumacher HR, Crane ML, Yarboro CH, Wilder RL, (2000) Adrenocorticotrophin, Glucocorticoid, and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of Inflammation. J of Clinical Endocrinology and Metab. 85:1461-1466.

410. Bornstein SR, Asab MA, Glasow A, Path G, Hauner H, Tsokos M, Chrousos GP, Scherbaum WA. (2000) 38

George P. Chrousos, M.D.

Immunohistochemical and Ultrastructural Localization of Leptin and Leptin Receptor in Human White Adipose Tissue and Differentiating Human Adipose Cells in Primary Culture. Diabetes. 49:532-538.

411. Willenberg HS, Bornstein SR, Hiroi N, Path G, Goretzki PE, Scherbaum WA, Chrousos GP, (2000) Effects of a Novel Corticotropin-Releasing -Hormone Receptor Type I Antagonist on Human Adrenal Function. Molec Psychiatry. 5:137-141.

412. Habib KE, Weld KP, Rice KC, Pushkas J, Champoux M, Listwak S, Webster EL, Atkinson A,Schulkin J, Contoreggi C, Chrousos GP, McCann SM, Suomi SJ, Higley JD, Gold PW. (2000) Oral Administration of a CRH Receptor Antagonist Significantly Attenuates Behavioral, Neuroendocrine, and Autonomic Responses to Stress in Primates. Proc Ntl Acad Sci USA. 10:1073-1079.

413. Berga SL, Loucks-Daniels TL, Adler LJ, Chrousos GP, Cameron JL, Matthews KA, Marcus MD. (2000) Cerebrospinal Fluid Levels of Corticotropin-Releasing Hormone in Women with Functional Hypothalamic Amenorrhea. Am J Obstet Gynecol. 182:776-784.

414. Hsin L-W, Webster EL, Chrousos GP, Gold PW, Eckelman WC, Contoreggi C, Rice KC. (2000) Synthesis of [3H] LWH-154: a Potent Radioligand for Corticotropin-Releasing Hormone Type 1 Receptor. J Labeled Compounds and Pharmaceuticals. 43:899-908.

415. Bornstein SR, Wolkersdorfer GW, Preas HL, Chrousos GP, Suffredini AF. (2000) Brief Report: Plasma Dehydroepiandrosterone (DHEA) Levels During Acute Experimental Endotoxemia and Antiinflammatory Therapy in Humans. Critical Care Med. 28(6):2103-2106.

416. Nawab SS, Miller CS, Dale JK, Greenberg BD, Friedman TC, Chrousos GP, Straus SE,Rosenthal NE. (2000) Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Research. 95:67-74.

417. Doppman JL, Chrousos GP, Papanicolaou DA, Stratakis CA, Alexander HR, Nieman LK. (2000) Adrenocorticotropin-independent Macronodular Adrenal Hyperplasia: An Uncommon Cause of Primary Adrenal Hypercortisolism. Radiology. 216(3):797-802.

418. Bottner A, Haidan A, Eisenhofer G, Kristensen K, Castle AL, Scherbaum WA, Schneider H, Chrousos GP, Bornstein SR. (2000) Increased Body Fat mass and Suppression of Circulating Leptin Levels in Response to Hypersecretion of Epinephrine in Phenylethanolamine-N-Methyltransferase (PNMT)-Overexpressing Mice. Endocrinology. 141(11):4239-4246.

419. Merke DP, Chrousos GP, Eisenhofer G, Weise M, Keil MF, Rogol AD, Van Wyk JJ, Bornstein SR. (2000) Adrenomedullary Dysplasia and Hypofunction in Patients with Classic 21-Hydroxylase Deficiency. N Engl J Med. 343(19):1362-1368.

420. Huang SC, Koch CA, Vortmeyer AO, Pack SD, Lichtenauer UD, Mannan P, Lubensky IA, Chrousos GP, Gagel RF, Pacak K, Zhuang Z. (2000) Duplication of the Mutant RET Allele in Trisomy 10 or Loss of the Wild-Type Allele in Multiple Endocrine Neoplasia Type 2-associated Pheochromocytomas. Cancer Research. 60:6223-6226.

421. Franchimont E, Bouma G, Galon J, Wolkersdorfer GW, Haidan A, Chrousos GP, Bornstein SR. (2000) Adrenal Cortical Activation in Murine Colitis. Gastroenterology. 119:1560-1568.

422. Bornstein SR, Tian H Haidan A, Bottner A, Hiroi N, Eisenhofer G, McCann SM, Chrousos GP, Roffler-Tarlov S. (2000) Deletion of Tyrosine Hydroxylase Gene Reveals Functional Interdependence of Adrenocortical and Chromaffin Cell System in Vivo. PNAS. 97:14742-14747.

423. Longui CA, Vottero A, Adamson PC, Cole DE, Kino T, Monte O, Chrousos GP. (2000) Low Glucocorticoid Receptor Alpha/beta Ratio in T-cell Lymphoblastic Leukemia. Horm Metab Res. 32:401-406.

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424. Garcia-Borreguero D, Wehr TA, Larrosa O, Granizo JJ, Hardwick D, Chrousos GP, Friedman TC. (2000) Glucocorticoid Replacement is Permissive for Rapid Eye Movement Sleep and Sleep Consolidation in Patients with Adrenal Insufficiency. J Clin Endocrinol Metab. 85:4201-4206.

425. Hope PJ, Tumbull H, Farr S, Morley JE, Rice KC, Chrousos GP, Torpy DJ, Wittert G.H. (2000) Peripheral Administration of CRF and Urocortin: Effects on Food Intake and the HPA axis in the Marsupial Sminthopsis crassicaudata. Peptides. 21:669-677.

426. Mitsiades N, Poulaki V, Tseleni-Balafouta S, Chrousos GP, Koutras DA. (2000) Fas Ligand Expression in Thyroid Follicular Cells from Patients with Thionamide-treated Graves’ Disease. Thyroid. 10:527-532.

427. Hauk PJ, Hamid QA, Chrousos GP, Leung DY. (2000) Induction of Corticosteroid Insensitivity by Microbial Superantigens. J All Clin Immunol. 105: 782-787

428. Merke DP, Cho D, Calis KA, Keil MF, Chrousos GP. (2001) Hydrocortisone Suspension and Hydrocortisone Tablets Are not Bioequivalent in the Treatment of Children with Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 86: 441-445.

429. Tian X, Hsin L-W, Webster E L, Contoreggi C, Chrousos GP, Gold PW, Habib K, Ayala A, Eckelman WC, Jacobson AE, Rice KC.(2001) The Development of a Potential Single Photon Emission Computed Tomography (SPECT) Imaging Agent for the Corticotropin-releasing Hormone Receptor Type 1. Bioorganic & Medicinal Chemistry Letters. 11: 331-333.

430. Vgontzas AN, Bixler EO, Wittman AM, Zachman K, Lin HM, Vela-Bueno A, Kales A, Chrousos GP. (2001) Middle-Aged Men Show Higher Sensitivity of Their Sleep to the Arousing Effects of Corticotropin-releasing Hormone than Younger Men: Clinical Implications. J Clin Endocrinol Metab. 86: 1489-95.

431. Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, Chrousos GP. (2001) Polycystic Ovary Syndrome is Associated with Obstructive Sleep Apnea and Daytime Sleepiness: Role of Insulin Resistance. J Clin Endocrinol Metab.86: 517-520.

432. Strickland I, Kisich K, Hauk PJ, Vottero A, Chrousos GP, Klemm DJ, Leung DYM. (2001) High Constitutive Glucocorticoid Receptor Beta in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids. J Exp Med.193: 585-593.

433. Päth G, Bornstein SR, Gurniak M, Chrousos GP, Scherbaum WA, Hauner H. (2001) Human Breast Adipocytes Express Interleukin (IL)-6 and its Receptor System: Increased IL-6 Production by beta-Adrenergic Activation and Effects of IL-6 on Adipocyte Function. J Clin Endocrinol Metab. 86: 2281-2288.

434. Erickson K, Thorsen P, Chrousos G, Grigoriadis DE, Khongsaly O, McGregor J, Schulkin J. (2001) Preterm Birth: Associated Neuroendocrine, Medical, and Behavioral Risk Factors. J Clin Endocrinol Metab.86: 2544- 2552.

435. Hiroi N, Chrousos GP, Abu-Asab M, Bonat S, Lafferty A, White A, Bornstein SR. (2001) Adrenocortical- Pituitary Hybrid Tumor Causing Cushing’s Syndrome. J Clin Endocrinol Metab.86: 2631-2637.

436. Cizza G, Dorn LD, Lotsikas A, Sereika S, Rotenstein D, Chrousos GP. (2001) Circulating Plasma Leptin and IGF-1 Levels in Girls with Premature Adrenarche: Potential Implications of a Preliminary Study. Hormone and Metabolic Research. 33:148-143.

437. Kraft M, Hamid O, Chrousos G, Martin RJ, Leung D. (2001) Decreased Steroid Responsiveness at Night: Is the Macrophage Responsible? Am J Resp Crit Care Med. 163:1219-1225.

438. Poulaki V, Mitsiades N, Mastorakos G, Caspi RR, Chrousos GP, Bouzas E. (2001) Fas/Fas ligand-associated Apoptosis in Experimental Autoimmune Uveoretinitis in Rodents: Role of Proinflammatory Corticotropin- releasing Hormone. Exp Eye Res.72:623-629. 40

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439. Schneider R, Bornstein SR, Chrousos GP, Boxberger S, Ehniger G, Breidert M. (2001) Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor. Horm Metab Res. 33(1):1-6.

440. Bernardini R, Johnson EO, Kamilaris T, Chiarenza A, Cantarella G, Calogero AE, Lempereur L, Chrousos GP, Giuffrida R, Gold PW. (2001) Increased ACTH and cortisol secretion after interleukin-alpha injection in the common marmoset (Callithrix jacchus jacchus). Life Sci. 68(14):1657- 65.

441. Baker DG, Ekhator NN, Kasckow JW, Hill KK, Zoumakis E, Dashevsky BA, Chrousos GP, Geracioti T. D.(2001) Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation. 9(4), 209-217.

442. Kuperman H, Damiani D, Chrousos GP, Dichtchenian V, Chrousos GP, Della Manna T, Filho VO, Setian N. (2001) Evaluation of the Hypothalamic-pituitary-adrenal Axis in Children with Leukemia before and after 7 Weeks of High Dose Glucocorticoid Therapy. J Clin Endocrinol Metab. 86: 2993-2996.

443. Kraft M, Hamid Q, Chrousos GP, Martin RJ, Leung DY. (2001) Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? Am J Respir Crit Care Med. 163: 1219-25.

444. Ghizzoni L, Barreca A, Mastorakos G, Furlini M, Vottero A, Ferrari B, Chrousos GP, Bernasconi S. (2001) Leptin inhibits steroid biosynthesis by human granulosa-lutein cells. Horm Metab Res. 33 : 323-8.

445. Vgontzas A, Bixler EO, Lin H-M, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos GP. (2001) Chronic Insomnia is Associated with Nyctohemeral Activation of the Hypothalamic-pituitary-adrenal Axis. J Clin Endocrinol Metab.86: 3787-3794.

446. Hiroi N, Wong ML, Licinio J, Park C, Gold PW, Chrousos GP, Bornstein SR. (2001) Expression of Corticotropin Releasing Hormone Receptors Type 1 and Type 2 mRNA in Suicide Victims and Controls. Mol Psychiatry. 6: 540-546.

447. Kohno M, Kawahito Y, Tsubouchi Y, Hashiramoto A, Yamada R, Inoue K, Kusaka Y, Kubo T, Elenkov IJ, Chrousos GP, Kondo M, Sano H. (2001) Urocortin Expression in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis: Relation to Inflammatory Activity. J Clin Endocrinol Metab. 86:4344-4352.

448. Makrigiannakis A, Zoumakis E, Kalantaridou S, Coutifaris C, Coukos G, Rice K, Gravanis A. Chrousos GP. (2001) Corticotropin-releasing Hormone (CRH) Promotes Blastocyst Implantation and Early Maternal Tolerance. Nature Immunology. 2:1018-24.

449. Abad V, Chrousos GP, Reynolds J, Nieman L, Hill S, Weinstein R, Leong G.(2001) Glucocorticoid Excess during Adolescence Leads to a Major, Persistent Deficit in Bone Mass and Increase in Central Body Fat. J Bone and Min Research. 16;1879-85.

450. Elenkov IJ, Wilder RL, Bakalov VK, Link AA, Dimitrov M, Fisher S, Crane M, Kanik K, Chrousos GP. (2001) Interleukin 12, Tumor Necrosis Factor-alpha and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times. J Clin Endocrinol Metab. 86:4933-8.

451. Kino T, Stauber RH, Resau JH, Pavlakis G, Chrousos GP. (2001) Pathologic Human Glucocorticoid Receptor (GR) Mutant Has a Transdominant Negative Effect on the Wild Type GR by Inhibiting Its Translocation into the Nucleus: Importance of the Ligand-binding Domain for Intracellular GR Trafficking. J Clin Endocrinol Metab. 86:5600-8.

452. Koch CA, Vortmeyer AO, Huang SC, Moley JF, Azumi N, Chrousos GP, Gagel RF, Zhuang S, Pacak K. (2001) Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma. Oncogene. 20:7809-11.

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453. Maurer M, Trajanoski Z, Hiroi N, Frey G, Galom J, Willenberg HS, Gold PW, Chrousos GP, Scherbaum WA, Bornstein SR. (2001) Differential gene expression profile of glucocorticoids, testosterone and dehydroepiandrosterone in human cells. Hormone Metab Res. 33:691-695.

454. Galon J, Franchimont D, Hiroi N, Boettner A, Ehrhart-Bornstein M, Chrousos GP, Bornstein S.(2002) Gene Profiling Reveals Unknown Enhancing and Suppressive Actions of Glucocorticoids on Immune Cells. FASEB J.16: 61-71.

455. Kino T, Slobodskaya O, Pavlakis N, Chrousos GP. (2002) Nuclear Receptor Coactivator p160 Proteins Enhance the Human Immunodeficiency Virus (HIV) Type 1 Long Terminal Repeat Promoter by Bridging . on-line release 11/01/01 277(4):2396- 405.

456. Hsin L-W, Tian X, Webster EL, Coop A, Caldwell TC, Jacobson AE, Chrousos GP, Gold PW, Habib KH, Ayala A, Eckelman WC, Contoreggi C, Rice. K. (2002) CRHR1 Receptor Binding and Lipophilicity of Pyrrolopyrimidines, Potential Nonpeptide Corticotropin-releasing Hormone Type 1 Receptor Antagonists. Biorg Med Chem. 10:175-183.

457. Koch CA, Huang SC, Zhuang Z, Stolle C, Azumi N, Chrousos GP, Vortmeyer AO, Pacak K (2002) Somatic VHL Gene Deletion and Point Mutation in MEN 2A-associated Pheochromocytoma. Oncogene. 21:479-482

458. Franchimont D, Galon J, Vacchio MS, Fan S, Visconti R, Frucht DM, Geenen V, Chrousos GP, Ashwell JD, O‟Shea JJ. (2002) Positive Effects of Glucocorticoids on T Cell Development and Function by Upregulation of Interleukin-7 Receptor. J Immunol. 168:2212-2218.

459. Koch CA, Vorrtmeyer AO, Diallo R, Poremba C, Giordano TJ, Sanders D, Bornstein SR, Chrousos GP, and Pacak K. (2002) Survivin: A Novel Neuroendocrine Marker for Pheochromocytoma. Eur J Endocrinol. 146: 381-388.

460. Mendonca BB, Leite MV, deCastro M, Kino T, Elias LL, Bachega TAS, Billerbeck AE, Arnhold IJP, Chrousos GP, Latronico AC. (2002) Female Pseudohermaphrodotism Caused by A Novel Homozygous Missence Mutation of the Glucocorticoid Receptor Gene. J Clin Endocrinol Metab. 87:1805-1809.

461. Meduri GU, Tolley EA, Chrousos GP, Stentz F. (2002) Prolonged Methylprednisolone Treatment Suppresses Systemic Inflammation in Patients with Unresolving ARDS: Evidence for Inadequate Endogenous Glucocorticoid Secretion and Inflammation-induced Immune Cell Resistance to Glucocorticoids. Am J Resp Crit Care Med. 165:983-991.

462. Sato H, Nagashima Y, Chrousos GP, Ichihashi M, Fusanaka Y. (2002) The Expression of Corticotropin- releasing Hormone in Melanoma. Pigment Cell Res. 15:98-103.

463. Charmandari E, Weise M, Bornstein S R, Eisenhofer G, Keil M F, Chrousos G, Merke DP. (2002) Children with Classic Congenital Adrenal Hyperplasia Have Elevated Serum Leptin Concentrations and Insulin Resistance. J Clin Endocrinol Metab. 87: 2139-2143.

464. Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvega S, Trimarchi F, Ehrhart- Bornstein M (2002) Adenoviral Vectors Can Impair Adrenocortical Steroidogenesis: Clinical Implications for Natural Infections and Gene Therapy. Proc Natl Acad Sci. USA 99:7484-7489 .

465. Vottero A, Kino T, Combe H, Lecomte P, Chrousos GP. (2002) A Novel, C-terminal Dominant Negative Mutation of the Glucocorticoid Receptor Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators. J Clin Endocrinol Metab. 87:2658-2667.

466. Greiner E, Atkinson AJ, Ayala A, Chrousos GP, Contoreggi C, Eckelman WC, Gold PW, Habib K, Jacobson AE, Webster EL, Rice KC. (2002) Synthesis of Doubly Labelled 13C Antalarmin Isotopomers for Pharmakokinetic Studies. J Lab Cpds and Radiopharmaceuticals. 45:637-645. 42

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467. Charmandari E, Eisenhofer G, Mehlinger S, Carlson A, Wesley R, Keil M, Chrousos GP, New MI, Merke DP. (2002) Adrenomedullary Function May Predict Phenotype and Genotype in Classic 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 87: 3031-3037.

468. Young IR, Chan EC, Smith R, Chrousos GP, Veldhuis JD, Canny BJ (2002) The Effect of Antalarmin, a Novel Corticotropin Releasing Hormone Antagonist on the Dynamic Function of the Preterm Ovine Fetal Hypothalamic-pituitary-adrenal axis. Neuroendocrinology. 76:47-54.

469. Webster EL, Barrientos RM, Contoreggi C, Isaac MG, Ligier S, Habib K, Chrousos GP, McCarthy EF, Rice KC, Gold PW, Sternberg EM. (2002) Corticotropin-releasing Hormone (CRH) Antagonist Attenuattes Adjuvant-induced Arthritis: Evidence Supporting Major Role for CRH in Peripheral Inflammation. J Rheumatol. 29: 1252-1261.

470. Gabry KE, Chrousos GP, Rice KC, Mostafa RM, Sternberg E, Negrao AB, Webster EL, McCann SM, Gold PW. (2002) Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Molec Psych. 7:474-483.

471. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler E, Prolo P, Lin H-M, Vela-Bueno A, Kales M d, and Chrousos GP. (2002) Chronic Insomnia is Associated with a Shift of IL- to Daytime. Metabolism. 29:1252-1261.

472. Koch CA, Mauro D, Walther MM, Linehan,WM, Vortmeyer AO, Jaffe R, Pacak K, Chrousos GP, Zhuang Z, Lubensky IA (2002) Pheochromocytoma in VHL Disease: Distinct Histopathologic Phenotype Compared to Pheochromocytoma in Multiple Endocrine Neoplasia Type 2. Endocrine Pathology 13:17-27.

473. Mansky PJ, Liewehr DJ, Steinberg SM, Chrousos GP, Avila NA, Long L, Bernstein D, Mackall CL, Hawkins DS, Helman LJ. (2002) Treatment of Metastatic Osteosarcoma with the Somatostatin Analog OncoLar: Significant Reduction of IGF-1 Serum Levels. J Ped Hematol Oncol. 24:440-446.

474. Pacak K, Tjurmina O, Palkovits M, Goldstein DS, Koch CA, Hoff T., Chrousos GP (2002) Chronic Hypercortisolemia Inhibits Dopaminergic Activity in the Nucleus Accumbens but not the Prefrontal Cortex: An in Vivo Microdialysis Study. Neuroendocrinology. 76:148-157.

475. Kino T, Gragerov A, Slobodskaya O, Tsopanomihalu-Nglotsou M, Chrousos GP, and Pavlakis G (2002) Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-responsive Promoters by Binding Directly to p300/CBP Coactivators. J Virol. 76:9724- 9734.

476. Kino T, Tsukamoto M, Chrousos GP. (2002) Transcription Factor TFIIH Components Enhance the GR Coactivator Activity but Not the Cell Cycle –arresting Activity of the Human Immunodeficiency Virus Type-1 Protein Vpr. Bioch Biophys Res Commun. 298: 17-23.

477. Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, Kino T. (2002) Human Immunodeficiency Type-1 (HIV- 1) Protein Vpr Suppresses Interleukin-12 Production from Human Monocytes by Enhancing Glucocorticoid Action: Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1 Infection. J Immunol. 169:6361-6368

478. Skalkidou A, Petridou E, Papathoma E, Salvanos H, Chrousos GP, Trichopoulos D. (2002) Birth Size and Neonatal Levels of Major Components of the IGF System: Implication for Later Risk of Cancer. J Ped Endocrinol Metab. 15: 1479-1486.

479. Bader T, Zoumakis E, Friedberg M, Hiroi N, Chrousos GP, Hochberg Z. (2002) Human Adipose Tissue under in Vitro Inhibition of 11beta-Hydroxysteroid Dehydrogenase Type 1: Differentiation and Metabolism Changes. Horm Metab Res. 34: 752-757.

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480. Wolkersdorfer GW, Bornstein SR, Higginbotham JN, Hiroi N, Vaquero JJ, Green MV, Blaese RM, Aguilera G, Chrousos GP, Bornstein SR. (2002) A Novel Approach Using Transcomplementing Adenoviral Vectors for Gene Therapy of Adrenocortical Cancer. Horm Metabol Res. 34: 279-287.

481. Kino T, Chrousos GP (2003) Tumor Necrosis Factor–alpha- and Fas-associated FLASH Inhibits Transcriptional Acivity of the Glucocorticoid Receptor by Binding to and Interfering with its Interaction with p160 Type Nuclear Receptor Coactivators. J Biol Chem. 278: 3023-3029.

482. Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D. (2003) Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case Control Study in Greece. J Clin Endocrinol Metab. 88: 983-997.

483. Tiosano D, Eisenstadt I, Militianu D, Chrousos GP , Hochberg Z. (2003) 11-Beta- Hydroxysteroid Dehydrogenase Activity in Hypothalamic Obesity. J Clin Endocrinol Metab. 88: 379-384.

484. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z. (2003) Modulation of 11-Beta- Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers. J Clin Endocrinol Metab. 88: 385- 393.

485. Marini JC, Hopkins E, Glorieux FH, Chrousos GP, Reynolds JC, Gundberg CM, Reing CM. (2003) Positive Linear Growth and Bone Responses to Growth Hormone Treatment in Children with Types III and IV Osteogenesis Imperfecta: High Predicitive Value of the Carboxyterminal Propeptide of Type I Procollagen. J Bone Miner Res. 18: 237-243.

486. Vottero A, Kimci-Sarfaty C, Kratzsch J, Chrousos GP, Hochberg Z. (2003) Transcriptional and Translational Regulation of the Splicing Isoforms of the Growth Hormone Receptor by Glucocorticoids. Horm Metab Res. 35: 7-12.

487. Vottero A, Kimcy-Sarfaty C, Kratzsch J, Miller G, Lafferty A, Chrousos GP, Hochberg Z. (2003) Relative Abudance of Growth Hormone Receptor Isoforms in Rhesus Monkey Tissues and Human Transformed Lymphocytes. Horm Metab Res. 35: 1-6.

488. Merke DP, Fields JD, Keil MF, Vaituzis C, Chrousos GP, Giedd JN. (2003) Children with Classic Congenital Adrenal Hyperplasia Have Decreased Amygdala Volume: Potential Prenatal and Postnatal Hormonal Effects. J Clin Endocrinol Metab. 88: 1760-1765.

489. Vgontzas AN, Zoumakis M, Bixler EO, Lin H-M, Prolo P, Vela-Bueno A, Kales A and Chrousos GP (2003) Impaired Nighttime Sleep Is Associated with Elevated Plasma IL-6 and Cortisol Levels in Healthy Old vs. Young Adults: Physiologic and Therapeutic Implications. J Clin Endocrinol Metab. 88: 2087-2095.

490. Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalou M, Wan Y, Chrousos GP. (2003) Protein 14-3-3 sigma Interacts with and Favors Cytoplasmic Subcellular Localization of the Glucocorticoid Receptor, Acting as a Negative Regulator of the Glucocorticoid Signaling Pathway. J Biol Chem. 252:32-44.

491. Alesci S, De Martino M, Mirani M, Benvega S, Trimarchi F, Kino T, Chrousos GP. (2003) L-Carnitine: A Nutritional Modulator of Glucocorticoid Receptor Functions. FASEB J. (Electronic release June 17). 17(11):1553-5.

492. Vozarova B, Weyer C, Snitker S, Gautier J-F, Cizza G, Chrousos G, Ravussin E, Tataranni PA. (2003) Effect of Cortisol on Muscle Sympathetic Nerve Activity in Pima Indians and Caucasians. J Clin Endocrinol Metab. 88: 3218-26.

493. Jagoda, E., Contoreggi, C Lee MJ, Kao CHK , Szajak LP , Listwak, Gold PW, Chrousos GP, Greiner E,. Jacobson AE, Rice KC, Eckelman W. (2003) Autoradiographic Visualization of Corticotropin Releasing Hormone Type 1 Receptors with a Nonpeptide Ligand: Synthesis of [ MJL-1-101-2. J Med Chem. 46:3559- 3562. 44

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494. Hiroi N, Kino T, Bassett M, Rainey WE, Phung M, Abu-Asab M, Fojo T, Briata P, Chrousos GP, Bornstein SR. (2003) Pituitary Homeobox Factor 1, A Novel Transcription Factor in the Adrenal Regulating Steroid 11Beta -hydroxylase. Horm Metab Res. 35: 273-8.

495. Skalkidou A, Petridou E, Papathoma E, Salvanos H, Kedikoglou S, Chrousos G, Trichopoulos D. (2003) Determinants and Consequences of Major Insulin-like Growth Factor Components among Full-term Neonates. Canc Epidemiol Biomark Prev. 12:860-865.

496. Contoreggi C, Herning RI, Na P, Gold PW, Chrousos GP, Negro PJ, Better W, Cadet JL. (2003) Stress Hormone Responses to Corticotropin–Releasing Hormone (CRH) in Substance Abusers without Severe Co- morbid Psychiatric Disease. Biol Psychiatry. 54: 873-878.

497. De Martino M, Bhattachryya N, Alesci S, Fabbri A, Chrousos GP, Kino T. (2004)The Glucocorticoid Receptor (GR) and the Orphan Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) Interact with and Mutually Affect Each Other‟s Transcriptional Activities: Implications for Intermediary Metabolism. Molecular Endocrinol. 18:820-833.

498. Kanaka-Gantenbein C, Kitsiou S, Mavrou A, Stamoyannou L, Kolialexi A, Kekou K, Liakopoulou M, Chrousos G. (2004) Tall Stature, Insulin Resistance, and Disturbed Behavior in a Girl with the Triple X Syndrome Harboring 3 SHOX Genes: Offspring of a Father with Mosaic Klinefelter Syndrome but with Two Maternal X Chromosomes. Horm Res. 61: 205-210.

499. Weise M, Mehlinger S, Rawson E, Charmandari E, Eisenhoffer G, Yanovski J, Chrousos GP, Merke D. (2004) Patients with Classic Congenital Adrenal Hyperplasia Have Decreased Epinephrine Reserve and Defective Glucose Elevation in Response to High Intensity Exercise, J Clin Endocrinol Metab. 89: 591-597.

500. Mantzoros C, Petridou E, Dessypris N, Chavelas H, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D. (2004) Adiponectin and Breast Cancer Risk J Clin Endocrinol Metab. 89: 1102-7.

501. Ward AM, Syddall HE, Wood PJ, Chrousos GP, Phillips DI. (2004) Fetal Programming of the Hypothalamic- pituitary-adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation. J Clin Endocrinol Metab. 89: 1227-33.

502. Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharayya N, Chrousos GP. (2004) Natural Glucocorticoid Receptor Mutants Causing Glucocorticoid Resistance: Molecular Genotype, Genetic Transmission and Clinical Phenotype. J Clin Endocrinol Metab. 89:1939-1949.

503. Charmandari E, Merke D, Negro PJ, Keil M, , Martinez PE, Haim A, Gold PW, Chrousos GP. (2004) Endocrinologic and Psychologic Evaluation of 21-Hydroxylase Deficiency Carriers and Matched Normal Subjects: Evidence for Physical and/or Psychologic Vulnerability to Stress. J Clin Endocrinol Metab. 89:2228- 2236.

504. Vgontzas A, Zoumakis E, Bixler EO, Lin H-M, Follett H, Kales A, Chrousos GP. (2004) Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines. J Clin Endocrinol Metab. 89:2119-2126.

505. Yuhas Y, Weizman A, Chrousos GP, Ovadia H, Ashkenazi S. (2004) Involvement of the Neuropeptide Corticotropin-releasing Hormone in an Animal Model of Shigella-related Seizures. J Neuroimmunol. 153: 36- 39.

506. Weise M, Drinkard B Mehlinger SL, Eisenhofer G, Chrousos GP, Merke DP (2004) Stress Dose of Hydrocortisone is not Beneficial in Patients with Classic Congenital Adrenal Hyperplasia Undergoing Short- term High-intensity Exercise. J. Clin. Endocrinol. Metab. 89: 3679-3684.

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507. Kalantaridou SN, Naka KK, Papanikolaou E, Kazakos N, Kravariti M, Calis KA, Paraskevaidis EA, Sideris DA, Tsatsoulis A, Chrousos GP, and Michalis LK (2004) Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy. J Clin Endocrinol Metab. 89: 3907- 3913.

508. Schulpis KH, Papassotiriou I, Vounatsou M, Karikas GA, Tsakiris S, Chrousos GP. (2004) Morning Preprandial Plasma Ghrelin and Catecholamine Concentrations in Patients with Phenylketonuria and Normal Controls: Evidence for Catecholamine-mediated Ghrelin Regulation. J Clin Endocrinol Metab. 89:3983-7.

509. Vgontzas AN, Zoumakis E, Lin H-M, Bixler EO, Chrousos GP. (2004) Marked Decrease of Sleepiness in -13.

510. Charmandari E, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T. Related Articles, Links (2005) The Human Glucocorticoid Receptor (hGR) {beta} Isoform Suppresses the Transcriptional Activity of hGR{alpha} by Interfering with Formation of Active Coactivator Complexes. Mol Endocrinol. 19: 52-64.

511. Glass JM, Lyden AK, Petzke F, Stein P, Whalen G, Ambrose K, Chrousos G, Clauw DJ. (2004) The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. J Psychosom Res. 57: 391-398.

512. Ayala AR, Pushkas J, Higley JD, Ronsaville D, Gold PW, Chrousos GP, Pacak K, Calis KA, Gerald M, Lindell S, Rice KC, Cizza C. (2004) Behavioral, Adrenal and Sympathetic Responses to Long Term Administration of an Oral Corticotropin-releasing Hormone Receptor Antagonist in a Primate Stress Paradigm. J Clin Endocrinol Metab 89: 5729-5737.

513. Tiulpakov A, Rubtsov P, Dedov I, Peterkova V, Bezlepkina O, Chrousos GP, Hochberg ZJ. (2005) A Novel C- terminal Growth Hormone Receptor (GHR) Mutation Results in Impaired GHR-Stat5 but Normal Stat3 Signaling. J Clin Endocrinol Metab. 90: 542-547.

514. Bloch M, Rubinow D, Schmidt PJ, Lotsikas A, Chrousos GP, Cizza G. (2005) Cortisol Response to oCRH in a Model of Pregnancy and Parturition in Euthymic Women with and without a History of Postpartum Depression. J Clin Endocrinol Metab. 90: 695-699.

515. Mantzoros C, Petridou E, Alexe DE, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Shetty E, Gavrila A, Kedikoglou S, Chrousos G, Trichopoulos D. (2004) Serum Adiponectin Concentrations in Relation to Maternal and Perinatal Characteristics in Newborns. Eur J Endocrinol. 151:741-746.

516. Kino T, Ichijo T, Chrousos G. (2004) FLASH Interacts with p160 Coactivator Subtypes and Differentially Suppresses Transcriptional Activity of Steroid Hormone Receptors. J Steroid Biochem and Molec Biol. 92: 357-363.

517. Kino T, Ichijo T, Charmandari E, De Martino M, Outas T and Chrousos GP. (2005) The Human Immunodeficiency Virus Type-1 (HIV-1) Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of the Forkhead Transcription Factors by Interfering with its Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding the Insulin Resistance of HIV-1-infected Patients. Diabetes. 54(1): 23-31.

518. Lycopoulou L, Mamoulakis C, Hantzi E, Demetriadis D, Antypas S, Giannaki M, Bakoula C, Chrousos G, Papassotiriou I. (2005) Serum Amyloid A Protein Levels as a Possible Aid in the Diagnosis of Acute Appendicitis in Children. Clin Chem Lab Med. 43(1): 49-53.

519. Cizza G, Romagni P, Lotsikas A, Lam G, Rosenthal NE, Chrousos GP. (2005) Plasma leptin in men and women with seasonal affective disorder and in healthy matched controls. Horm Metab Res. 37(1): 45-48.

520. Alesci S, Martinez P,Kelkar S, Ilias I, Ronsaville DS, Listwak SJ,.Ayala AR, Licinio J, Gold H, Kling MA, Chrousos GP, Gold PW. (2005) Major Depression Is Associated with Significant Diurnal elevations In Plasma 46

George P. Chrousos, M.D.

IL-6 Levels, A Shift of Its Circadian Rhythm, and loss of physiologic complexity in its secretion: Clinical Implications. J Clin Endocrinol Metab. 90:2522-2530.

521. Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Cohen-Erwin R, Chrousos GP and Pavlakis GN. (2005) Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to 14-3-3 Proteins and Facilitates Complex Formation with Cdc25C: Implications for Cell Cycle Arrest. J Virol. 79:2780-2787.

522. Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D. (2005) Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf). 62(3):366-71.

523. Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs E, Holzer S, Rawson E, Vaituzis AC, Stratakis CA, Chrousos GP. (2005) Children Experience Cognitive Decline Despite Reversal of Brain Atrophy One Year Following Resolution of Cushing Syndrome. J Clin Endocrinol Metab. 90:2531-2536.

524. Fruchter O, Kino T, Zoumakis E, Alesci S, De Martino, M, Chrousos G, Hochberg Z.(2005) The Human Glucocorticoid Receptor (GR) Isoform  Differentially Suppresses GR-induced Transactivation Stimulated by Synthetic Glucocorticoids. J Clin Endocrinol Metab. 90:3505-3509.

525. Charnandari E, Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP. (2005) A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of C-terminus of hGR LBD in Conferring Transactivational Activity. J Clin Endocrinol Metab. 90: 3696-3705.

526. Rubinow DR, Roca CA, Schmidt PJ, Danaceau MA, Putnam K, Cizza G, Chrousos G, Nieman L. (2005) Testosterone Suppression of CRH-Stimulated Cortisol in Men. Neuropsychopharmacology. 30:1906-1912.

527. Margeli A, Skenderi K, Tsironi M, Hantzi E, Matalas AL, Vrettou C, Kanavakis E, Chrousos G, Papassotiriou I. (2005) Dramatic Elevations of Interleukin-6 and Acute Phase Reactants in Athletes Participating in the Ultradistance Foot Race "Spartathlon": Severe Inflammation and Lipid and Lipoprotein Changes in Protracted Exercise. J Clin Endocrinol Metab. 90: 3914-3918.

528. Putnam K, Chrousos GP, Nieman LK, Rubinow DR. (2005) Sex-Related Differences in Stimulated HPA Axis During Induced Gonadal Suppression. J Clin Endocrinol Metab. 90: 4224-4231.

529. Gold PW, Wong M-L, Goldstein D, Gold H, Ronsaville D, Esler M, Alesci S, Masood A, Licinio J, Geraciotti TD, Perini GI, DeBellis MD, Vgontzas AN, Charney DS, Chrousos GP, McCann SM and Kling MA. (2005) Cardiac Implications of Increased Arterial Entry and Reversible 24-h Central and Peripheral Norepinephrine Levels in Melancholia. Proc Natl Acad of Sci USA.102: 8303-8308.

530. Deuster PA, Faraday MM, Chrousos GP, Poth MA. (2005) Effects of Dehydroepiandrosterone and Alprazolam on Hypothalamic-Pituitary Responses to Exercise. J Clin Endocrinol Metab. 90:4777-4783.

531. Manoli I, Hanh Le H, Alesci S, McFann KK, Su Y, Kino T, Chrousos GP, Blackman MR. (2005) Monoamine Oxidase-A is a Major Target Gene for Glucocorticoids in Human Skeletal Muscle Cells: Induction of Gene and Oxidative Activity and Relevance to Glucocorticoid- Mediated Myopathy. FASEB J. 19:1359-1361.

532. Million M, Maillot C, Adelson DA, Nozu T, Gauthier A, Rivier J, Chrousos GP, Bayati A. Mattsson H, Tache Y. (2005) Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats. Peptides. 26(7):1188-1195.

533. Kravariti M, Naka KK, Kalantaridou SN, Kazakos N, Katsouras CS, Makrigiannakis A, Paraskevaidis EA, Chrousos GP, Tsatsoulis A, Michalis LK. (2005) Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 90:5088-95.

534. Johnson EO, Kamilaris TC, Calogero AE, Gold PW, Chrousos GP. (2005) Experimentally-induced 47

George P. Chrousos, M.D.

hyperthyroidism is associated with activation of the rat hypothalamic-pituitary-adrenal axis. Eur J Endocrinol. 153:177-185.

535. Nishikawa T, Suematsu S, Saito J, Soyama A, Ito H, Kino T, Chrousos G (2005).Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL). J Steroid Biochem Mol Biol. 96:309-316.

536. Chrousos GP, Ghaly L, Shedden, A,. Iezzoni D, Harris AG. (2005) Effects of Mometasone Furoate Dry Powder Inhaler and Beclomethasone Dipropionate Hydrofluroalkane and Chlorofluorocarbon on the Hypothalamic-pituitary-adrenal axis in Asthmatic Subjects. Chest. 128:70-77.

537. Kino T, Ichijo T, Tiulpakov A Chheng L, Kozasa T, Chrousos GP. (2005) The GTP-binding (G) Protein  Interacts with the Activated Glucocorticoid Receptor and Suppresses Its Transcriptional Activity in the Nucleus. J Cell Biol. 169(6):885-96.

538. Kakourou T, Kanaka-Gantenbein C, Papadopoulou A, Kaloumenou E, Chrousos GP. (2005) Increased prevalence of chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo. J Am Acad Dermatol. 53(2):220-3.

539. Kino T, Kozasa T, Chrousos GP. (2005) Statin-induced Blockade of Prenylation Alters Nucleocytoplasmic Shuttling of GTP-binding Proteins 2 and 2 and Enhances their Suppressive Effect on Glucocorticoid Receptor Transcriptional Activity. Eur J Clin Invest. 35:508-513.

540. Schulpis KH, Papassotiriou I, Tsakiris S, Vounatsou M, and Chrousos GP (2005) Increased Plasma Adiponectin Concentrations in Poorly Controlled Patients with Phenyketonuria (PKU) Normalize with a Strict Diet: Evidence for Catecholamine-mediated Adiponectin Regulation and a Complex Effect of PKU Diet on Atherogenesis Risk Factors. Metabolism. 54:1350-1355.

541. Siahanidou T, Mandyla H, Vounatsou M, Anagnostakis D, Papassotiriou I, and Chrousos GP. (2005) Circulating Peptide YY Concentrations Are Higher in Preterm than Term Infants and Correlate Negatively with Body Weight and Positively with Serum Ghrelin Levels. Clin Chemistry. 51(11):2131-7.

542. Papoutsi Z, Kassi E, Tsiapara A, Fokialakis N, Chrousos GP, Moutsatsou P. (2005) Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERalpha and ERbeta. J Agric Food Chem. 53(20):7715-7720.

543. Papoutsi Z, Kassi E, Mitakou S, Aligiannis N, Chrousos GP, Moutsatsou P. (2006) Acteoside and Martynoside Exhibit Estrogenic/Antiestrogenic Activity. J Steroid Biochem and Mol Biol 98(1):63-71. Epub 2005 Sep 28.

544. Ichijo T, Voutetakis A, Cotrim AP, Bhattachryya N, Fujii M, Chrousos GP, Kino T. (2005) The SMAD6/histone Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: Potential Clinical Implications. J Biol Chem. 280(51):42067-77.

545. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras S, Yannakoulia M, Chrousos G, Sidossis L. (2005) Aerobic Exercise Training Improves Insulin Sensitivity without Changes in Body Weight, Body Fat, Adiponectin and Inflammatory Markers in Overweight and Obese Girls. Metabolism. 54(11): 1472- 1479.

546. Papandreou O, Soldatou A, Tsitsika A, Cariyannis C, Papandreou T, Papassotiriou, Zachariadi A, Chrousos GP. (2005) Serum S100beta Protein in Children with Acute Recurrent Headache: A Potentially Useful Marker for Migraine. Headache. 45:1313-1316.

547. Kino T, Liou S-H, Charmandari E, Chrousos GP. (2005) Pathologic Human Glucocorticoid Receptor Mutants Demonstrate Defective Motility inside the Nucleus of Living Cells: Percent Recovery Time afterPhotobleaching (FRAP) is an Integrated Measure of Receptor Function. Mol Med. 10(7-12): 80-8.

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548. Bamberger AM, Minas V, Kalantaridou S, Radde J, Sadeghian H, Loening T, Charalambopoulos J, Bruemmer J, Wagener C, Bamberger CM, Schulte HM, Chrousos GP, Makrigiannakis A. (2005) Corticotropin-releasing Hormone Modulates Human Trophoblast Invasion through CEACAM-1 Regulation. Am J Pathol. 68(1):141- 50.

549. Meduri GU, Muthiah MP, Carratu P, Eltorky M, Chrousos GP. (2005) Nuclear factor-B- and Glucocorticoid Receptor a- mediated Mechanisms in Regulation of Systemic and Pulmonary Inflammation during Sepsis and Acute Respiratory Distress Syndrome: Evidence for Inflammation–induced Target Tissue Resistance to Glucocorticoids. Neuroimmunomodulation. 12(6): 321-38.

550. Nicolaidou P, Papadopoulou A, Georgouli H, Matsinos YG, Tsapra H, Fretzayas A, Giannoulia-Karantana A, Kitsiou S, Douros K, Papassotiriou I, Chrousos GP. (2006) Calcium and Vitamin D Metabolism in Hypocalcemic Vitamin D-Resistant Rickets Carriers. Horm Res. 65(2):83-88.

551. Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP (2006) Functional Characterization of the Natural Human Glucocorticoid Receptor (GR) Mutants hGRalphaR477H and hGRalphaG679S Associated with Generalized Glucocorticoid Resistance. J Clin Endocrinol. 91:1535-1543.

552. Ronsaville DS, Municchi G, Laney C, Cizza G, Meyer SE, Haim A, Radke-Yarrow M, Chrousos, GP, Gold PW, Martinez PE. (2006) Maternal and Environmental Factors Influence the Hypothalamic-pituitary-adrenal axis Response to Corticotropin-releasing Hormone Infusion in Offspring of Mothers with or without Mood Disorders. Develop Psychopathol 18(1): 173-94.

553. Alesci S, Manoli I, Su Y, Blackman M, Rennert O, Chrousos GP. (2006) Development of a New Mitochondria-focused cDNA Microarray (hMitChip): Validation in Skeletal Muscle Cells and Implications for Pharmaco-and Mitogenomics. The Pharmacogenomics J. 6(5):333-42.

554. Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP, Segars JH. (2006) Rho Family Guanine Nucleotide Exchange Factor Brx Couples Extracellular Signals to the Glucocorticoid Signaling System. J Biol Chem. 281:9118-9126.

555. Krisnamoorthy S, Bei T, Zoumakis E, Chrousos GP, Iliadis AA. (2006) Morphological and Binding Properties of Interleukin-6 on Thin ZnO Films Grown on (100) Silicon Substrates for Biosensor Applications. Biosens Bioelectron. 22:707-14.

556. Giedd JN, Clasen LS, Lenroot R, Greenstein D, Wallace GL, Ordaz S, Molloy EA, Blumenthal JD, Tossell JW, Stayer C, Samango-Sprouse CA, Shen D, Davatzikos C, Merke D, Chrousos GP. (2006) Puberty-related influences on brain development. Mol Cell Endocrinol. 254-255:154-62.

557. Vgontzas AN, Trakada G, Bixler EO, Lin H-M, Pejovic S, Zoumakis E, Chrousos, GP, Legro R. (2006) Plasma IL-6 and TNF-alpha Levels are Elevated in Polycystic Ovary Syndrome Independently of Obesity and Sleep Apnea. Metabolism. 55:1076-82.

558. Priftis K, Papadimitriou A, Anthracopoulos B, Gatsopoulou E, Fretzayas A, Nicolaidou P, Chrousos G. (2006) Adrenal Function Improvement in Asthmatic Children on Inhaled Steroids Studied Longitudinally. Neuroimmunomodulation. 13(1):56-62.

559. Vgontzas AN, Pejovic, S, Zoumakis E, Lin H-M, Bixler EO, Basta M, Fang J, Sarrigiannidis A, Chrousos GP. (2007) Daytime Napping After a Night of Sleep Loss Decreases Sleepiness, Improves Performance, and Causes Beneficial Changes in Cortisol and Interleukin-6 Secretion. Am J Physiol Endocrinol Metab 292:E253- 61.

560. Fruchter O, Zoumakis E, Alesci S, De Martino M, Chrousos G, Hochberg Z. (2006) Intracrine modulation of gene expression by intracellular generation of active glucocorticoids. Steroids. 71:1001-6.

561. Leong GM, Abad V, Charmandari E, Reynolds JC, Hill S, Chrousos GP, Nieman LK. (2007). The effects of 49

George P. Chrousos, M.D.

child- and adolescent-onset endogenous Cushing syndrome on areal and volumetric bone mineral density, body composition and growth: a 7-year prospective study into young adulthood. J Bone Miner Res. 22(1):110-8.

562. Siahanidou T, Mandyla H, Papassotiriou GP, Papasotiriou I, Chrousos GP. (2007) Circulating Levels of Adiponectin in Preterm Infants. Arch Dis Child Fet Neon. 92(4):F286-90.

563. Nicolaidou P, Papadopoulou A, Matsinos YG, Georgouli H, Fretzayas A, Papadimitriou A, Priftis K, Douros K, Chrousos GP. (2006) Vitamin D Receptor Polymorphisms in Hypocalcemic Vitamin D-Resistant Rickets Carriers. Horm Res. 67(4):179-183 [Epub ahead of print].

564. Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CN, and the Obesity and Cancer Oncology Group. (2007) Low Adiponectin Levels are Associated with Renal Cell Carcinoma: A Case- control Study. Inter J Cancer. [Epub ahead of print] 120: 1573-8.

565. Arditi JD, Venihaki M, Karalis KP, Chrousos GP. (2007) Anti-proliferative Effect of Adiponectin on MCF7 Breast Cancer Cells: A Potential Hormonal Link between Obesity and Cancer. Horm Metabol Res. 39:9-13.

566. Alevizaki M, Cimponeriu A, Lekakis J, Papamichael C, Chrousos GP. (2007) High Anticipatory Stress Plasma Cortisol and Increased Sensitivity to Glucocorticoids Predict Severity of Coronary Artery Disease in Subjects Undergoing Coronary Angiography. Metabolism 56:222-6.

567. Kakourou T, Karachristou K and Chrousos GP. (2007) A Case Series of Alopecia Areata in Children: Impact of Personal and Family History of Stress and Autoimmunity. JADV. 21:356-359.

568. Bartzeliotou AI, Margeli AP, Tsironi M, Skenderi K, Bacoula C, Chrousos GP, Papassotiriou I. (2007) Circulating levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged brisk exercise. Clin Biochem. 40(11):765-70.

569. Krekoukia M, Nassis GP, Psarra G, Skenderi K, Chrousos GP, Sidossis LS. (2007) Elevated total and central adiposity and low physical activity are associated with insulin resistance in children. Metabolism. 56(2):206-13

570. Bai X, Wu J, Zhang Q, Alesci S, Manoli I, Blackman MR, Chrousos GP, Goldstein AL, Rennert OM, Su YA. (2007) The Third-Generation Human Mitochondria-focused cDNA Microarray (hMitChip3) and its Bioinformatics Tool for Analysis of Gene Expression. BioTechniques. 42:365-375.

571. Chrousos GP, O‟Dowd L, Uryniak T, Simpson B, Casty M, Goldman M/ (2007) Basal and Cosyntropin- stimulated Plasma Cortisol Concentrations, as Measured by High-performance Liquid Chromatography, in Children Aged 5 Months to <6 Years. J Clin Endocrinol Metab. 92(6):2125-9.

572. Kino T, Rice KC, Chrousos GP. (2007) The PPAR  Agonist GW501516 Suppresses Interleukin-6 Action via STAT3 Inhibition. Eur J Clin Invest. 37:425-433.

573. Xekouki P, Nikolakopoulou NM, Papageorgiou A, Livadas S, Voutetakis A, Magiakou MA, Chrousos GP, Spiliotis BE, Dacou-Voutetakis C. (2007) Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential Protective Factors. Obesity (Silver Spring). 15: 860-869.

574. Kino T, Ichijo T, Amin ND, Kesavapany S, Amin ND, Wang Y, Kim N, Player A, Garabedian MJ, Kawasaki E, Pant HC, Chrousos GP. (2007) Cyclin-dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress. Mol Endocrinol. 21(7):1552-68

575. Papaevangelou V, Papassotiriou I, Vounatsou M, Chrousos G, Theodoridou M. (2007) Changes in leptin serum levels in HIV-infected children receiving highly active antiretroviral therapy. Scand J Clin Lab Invest. 67:291- 6.

576. Nicolaidou P, Tsitsika A, Papadimitriou A, Karantana A, Papadopoulou A, Psychou F, Liakopoulou D, 50

George P. Chrousos, M.D.

Georgouli H, Kakourou T, Chrousos G. (2007) Hereditary vitamin D-resistant rickets in Greek children: genotype, phenotype, and long-term response to treatment. J Pediatr Endocrinol Metab. 20:425-30.

577. Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC, Chrousos GP. (2007) 3-O-formyl-20R,21- Epoxyresibufogenin Suppresses Interleukin 6-type Cytokine Actions by Targeting the gp130 Subunit : Potential Clinical Implications. J All Clin Immunol. 120:437-444.

578. Trimis G, Moschovi M, Papassotiriou I, Chrousos G, Tzortzatou-Stathopoulou F. (2007) Early Indicators of Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for Preventing Disease. J Pediatr Hematol Oncol. 29:309-314.

579. Mantzoros CS, Trakatelli M, Gogas H, Dessypris N, Stratigos A, Chrousos GP, Petridou ET. (2007) Circulating adiponectin levels in relation to melanoma: A case-control study. Eur J Cancer. 43:1430-6.

580. Mills JL, Hediger ML, Molloy CA, Chrousos GP, Manning-Courtney P, Yu KF, Brasington M, England LJ (2007) Elevated Levels of Growth-Related Hormones in Autism and Autism Spectrum Disorder. Clin Endocrinol. 67:230-237.

581. Siahanidou T, Mandyla H, Militsi H, Papassotiriou I, Chrousos G. (2007) Peptide YY (3-36) Represents a High Percentage of Total PYY Immunoreactivity in Preterm and Full-Term Infants and Correlates Independently With Markers of Adiposity and Serum Ghrelin Concentrations. Pediatr Res. 62(2):200-3.

582. Livadas S, Magiakou MA, Mengreli C, Girginoudis P, Galani C, Smyrnaki P, Kanaka-Gantenbein C, Xekouki P, Chrousos GP, Dacou-Voutetakis C. (2007) Obesity and Attenuated Adiposity Rebound in Children with Congenital Hypothyroidism. Normalization of BMI Values in Adolescents. Horm Metab Res. 39:524-528.

583. Pervanidou P, Kolaitis G, Charitaki S, Lazaropoulou Ch, Papassotiriou I, Hindmarsh P, Bakoula Ch, Tsiantis J, Chrousos GP. (2007) The Natural History of Neuroendocrine Changes in Pediatric Post-traumatic Stress Disorder (PTSD) after Motor Vehicle Accidents: Progressive Divergence of Noradrenaline and Cortisol Concentrations over Time. Biol Psychiatry 62(10):1095-102.

584. Charmandari E, Kino T, Ichijo T, Jubiz W, Zachman K, Chrousos GP. (2007) A Novel Point Mutation in Helix 11 of the Ligand-binding Domain (LBD) of the Human Glucocorticoid Receptor (GR) Gene Causing Generalized Glucocorticoid Resistance. J Clin Endocrinol Metab. 92:3986-3990.

585. Minas V, Rolaki A, Kalantaridou SN, Sidiropoulos J, Mitrou S, Petsas G, Jeschke U, Paraskevaidis EA, Fountzilas G, Chrousos GP, Pavlidis N, Makrigiannakis A (2007) Intratumoral CRH Modulates Immuno-escape of Ovarian Cancer Cells through FasL Regulation. Br J Cancer. 97(5):637-45.

586. Vgontzas AN, S Pejovic S, Zoumakis E, Lin H-M, Bechtel C, EO Bixler EO, A. Sarrigiannidis A, Basta M, Chrousos GP. (2007) Hypothalamic-Pituitary-AdrenalAxis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy. J Clin Endocrinol Metab. 92: 4199-4207.

587. Pervanidou P, Kolaitis G, Charitaki S, Margeli A, Ferentinos S, Bakoula C, Lazaropoulou C, Papassotiriou I, Tsiantis J, Chrousos GP. (2007) Elevated Morning Serum Interleukin (IL)-6 or Evening Salivary Cortisol Concentrations Predict Posttraumatic Stress Disorder in Children and Adolescents Six Months after a Motor Vehicle Accident. Psychoneuroendocrinology. 32(8-10):991-9.

588. Pavlatou MG, Mastorakos G, Lekakis I, Liatis, Vamvakou G, Zoumakis E, Papassotiriou I, Rabavilas AD, Katsilambros N, Chrousos GP. (2007) Chronic Administration of an Angiotensin II Receptor Antagonist Resets the Hypothalamic-pituitary-adrenal Axis and Improves the Affect of Patients with Diabetes Mellitus Type 2: Preliminary Results. Stress. 11(1):62-72.

589. Hoffman KE, Derdak J, Bernstein D M, Reynolds JC, Avila NA, Gerber L, Steinberg S, Chrousos G, Mackall CL, Mansky PJ. (2008) Metabolic Syndrome Traits in Long-term Survivors of Pediatric Sarcoma at a Single Institution. Ped Blood and Cancer. 50(2):341-6. 51

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590. Shrivastav S, Kino K, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB. (2007) HIV-1 Vpr suppresses transcriptional activity of PPAR and inhibits adipocyte differentiation: Implications for HIV- associated lipodystrophy. Mol Endo. 22:234-247.

591. Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, Chrousos GP, Petridou ET. (2007) Melanoma risk in association with serum leptin levels and lifestyle parameters: a case–control study. Ann Oncol. 19:384389

592. Ichijo T, Chrousos GP, KinoT. (2007) Activated Glucocorticoid Receptor Interacts with the INHAT Component Set/TAF-I and Releases it from a Glucocorticoid-responsive Gene Promoter, Relieving Repression: Implications for the Pathogenesis of Glucocorticoid Resistance in Acute Undifferentiated Leukemia with Set-Can Translocation. Mol Cell Endocrinol. 283:19-31.

593. Karamessinis PM, Malamitsi-Puchner A, Boutsikou T, Makridakis M, Vougas K, Fountoulakis M, Vlahou A, Chrousos G. (2007) Marked defects in the expression and glycosylation of alpha -2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: Proteomic screening and potential clinical implications. Mol Cell Proteomics. 7:591-599.

594. Pervanidou P, Margeli A, Lazaropoulou C, Papassotiriou I, Chrousos GP (2008) The Immediate and Long- term Impact of Physical or Emotional Stress from Motor Vehicle Accidents on Circulating Stress Hormones and Adipo-cytokines in Children and Adolescents. Stress. 11: 438-447.

595. Vgontzas AN, Lin H-M, Papaliagka M, Calhoun S, Vela-Bueno A, Chrousos GP, O. Bixler EO (2008) Short Sleep Duration and Obesity: The Role of Emotional Stress and Sleep Disturbances Int J Obes (Lond). 32(5):801-809.

596. Skenderi KP, Tsironi M, Lazaropoulou C, Anastasiou CA, Matalas AL, Kanavaki I, Thalmann M, Goussetis E, Papassotiriou I, Chrousos GP. (2008) Changes in free radical generation and antioxidant capacity during ultramarathon foot race. Eur J Clin Invest. 38 (3):159-165.

597. Krishnamoorthy S, Iliadis A A, Bei T, Chrousos G. (2008) ZnO SAW Biosensor for Interleukin-6 Detection. Biosensors and Bioelectronics. 24(2):313-8.

598. Kanaka-Gantenbein C, Margeli A, Pervanidou P, Sakka S, Mastorakos G, Chrousos GP, Papassotiriou I. (2008) Retinol Binding Protein-4 and Lipocalin-2 in Childhood and Adolescent Obesity: When Children are not just Small Adults. Clin. Chem. 54(7):1176-82.

599. Moschovi M, Trimis G, Vounatsou M, Katsibardi K, Margeli A, Dimitriadi F, Papassotiriou I, Chrousos GP, Tzortzatou-Stathopoulou F. (2008) Serial Plasma Concentrations of PYY and Ghrelin during Chemotherapy in Children with Acute Lymphoblastic Leukemia. J Ped Hem Oncol. 30: 733-737.

600. Vgontzas AN, Zoumakis E, Bixler EO, Lin H-M, Collins B, Basta M, Pejovic S, Chrousos GP. (2008) Selective Effects of CPAP on Sleep Apnea-related Manifestations. Eur J. Clin Invest. 38: 585-595

601. Elenkov1J, Kvetnansky R, Hashiramoto A, Bakalov VK, Link AA, Zachman K, Crane M, Jezova D, Rovensky J, Dimitrov MA, Gold PW, Bonini S, Fleisher T, Chrousos GP , Wilder RL. (2008) Low versus High Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-like Neurohormonal-Immune Phenotypes in Humans. J Immunol. 181:1737-1745.

602. Kaloumenou I, Mastorakos G, Alevizaki M, Duntas LH, Mantzou E, Ladopoulos C, Antoniou A, Chiotis D, Papassotiriou I, Chrousos GP, Dacou-Voutetakis C. (2008) Thyroid autoimmunity in schoolchildren in an area with long-standing iodine sufficiency: correlation with gender, pubertal stage, and maternal thyroid autoimmunity. Thyroid. 18(7):747-54.

603. Charmandari E, Ichijo T, Jubiz W, Baid S, Zachman K, Chrousos GP, Kino T. (2008) A Novel Point Mutation 52

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in the Amino Terminal Domain of the Human Glucocorticoid Receptor (hGR) Gene Enhancing hGR-mediated Gene Expression. J Clin Endocrinol Metab. 93(12):4963-8.

604. Nader N, Chrousos GP and Kino T (2009) Circadian Rhythm Transcription Factor CLOCK Regulates the Transcriptional Activity of the Glucocorticoid Receptor by Acetylating its Hinge Region Lysine Cluster: Potential Physiologic Implications. FASEB J. 23:1572-83.

605. Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, and Segars JH (2009) Guanine Nucleotide Exchange Factor Brx Mediates Lymphocyte Adaptive Response to Osmotic Stress: An Intracellular Signaling Pathway Linking Extracellular Hyperosmosis and Immune Activation. Science Signaling 2(57) RA5.

606. Fishbein D, Sheppard M, Hyde C, Hubal R, Newlin D, Serin R, Chrousos G, Alesci S (2009) Deficits in Behavioral Inhibition Predict Treatment Engagement in Prison Inmates. Law Hum Behav. 33(5):419-35. doi: 10.1007/s10979-008-9163-7. Epub 2009 Jan 13.

607. Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, Kanaka-Gantenbein C (2009) Euthyroid Hyperthyrotropinemia in Children Born after In Vitro Fertilisation. J Clin Endocrinol Metab. 94(4):1338-41. doi: 10.1210/jc.2008-1624. Epub 2009 Feb 3.

608. Bakoula C, Kolaitis G, Veltsista A, Gika A, Chrousos GP. (2009) Parental stress affects the emotions and behaviour of children up to adolescence: A Greek prospective, longitudinal study. Stress. 12(6):486-98. doi: 10.3109/10253890802645041.

609. Piaditis GP, Kaltsas GA, Androulakis II, Gouli A, Makras P, Papadogias D, Dimitriou K, Ragkou D, Markou A, Vamvakidis K, Zografos G, Chrousos G. (2009) High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas. Clin Endocrinol (Oxf). 71(6):772-8. doi: 10.1111/j.1365-2265.2009.03551.x. Epub 2009 Feb 18.

610. Kino T, Manoli I, Kelkar S, Wang Y, Su YA and Chrousos GP (2009) Human Glucocorticoid Receptor (GR) Isoform  Has Intrinsic, GR-independent Transcriptional Activity. Biochem Biophys Res Commun. 381(4):671-5. doi: 10.1016/j.bbrc.2009.02.110. Epub 2009 Feb 25.

611. Loizou S, Paraschos S, Mitakou S, Chrousos G, Lekakis I, Moutsatsou P (2009) Chios Mastic Gum Extract and Isolated Phytosterol Tirucallol Exhibit Anti-inflammatory Activity in Human Aortic Endothelial Cells. Exp Biol Med (Maywood). 234(5):553-61. doi: 10.3181/0811-RM-338. Epub 2009 Feb 20.

612. Livadas S, Dracopoulou M, Vasileiadi K, Lazaropoulou C Magiakou MA, P Xekouki P, Voutetakis A, Kanaka-Gantenbein C, Papassotiriou I, Stefanadis C, Chrousos GP, Dacou-Voutetakis C (2009) Elevated coagulation and inflammatory markers in adolescents with a history of premature adrenarche. Metabolism. 58: 576–581.

613. Spyridopoulos TN, Petridou ET, Dessypris N, Terzidis A, Skalkidou A, Deliveliotis C, Chrousos GP; Obesity and Cancer Oncology Group. (2009) Inverse association of leptin levels with renal cell carcinoma: results from a case-control study. Hormones (Athens). 8: 39-46.

614. Bixler EO, Papaliaga MN, Vgontzas AN, Lin HM, Pejovic S, Karataraki M, Vela-Bueno A, Chrousos GP. (2009) Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause. J Sleep Res. 18(2):221-8. doi: 10.1111/j.1365-2869.2008.00713.x. Epub 2009 Mar 12.

615. Vgontzas AN, Liao D; Bixler EO, Chrousos GP, Vela-Bueno A. (2009) Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension. Sleep. 32:491-497.

616. Pervanidou P, Margeli A, Akalestos A, Sakka S, Kanaka-Gantenbein C, Papassotiriou I and GP Chrousos (2009) Associations between Circulating N-type Brain Natriuretic Peptide (NT-proBNP) and Adiponectin 53

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Concentrations Depend on Obesity Level in Female Adolescents: Gender Dimorphic Findings. Horm Metab Res.41: 829-833

617. Livadas S, Dracopoulou M, Lazaropoulou C, Papassotiriou I, Sertedaki A, Angelopoulos N, Chrousos GP and Dacou-Voutetakis A (2009) A Favorable Metabolic and Antiatherogenic Profile in Carriers of CYP21A2 Gene Mutations Supports the Theory of a Survival Advantage in this Population. Horm Res. 72:337-343.

618. Moschovi M, Trimis G, Vounatsou M, Katsibardi K, Margeli A, Damianos A, Chrousos G, and Papassotiriou I (2010) Serial Plasma Concentrations of Adiponectin, Leptin, and Resistin During Therapy in Children with Acute Lymphoblastic Leukemia. J Ped Hematol Oncol. 32(1):e8-13.

619. Lang L, Y. Ma Y, Kim BM, Jagoda EM, Rice KC, Szajek LP, Contoreggi C, Gold PW, Chrousos GP, Eckelman WC, and Kiesewetter DO (2009) [76Br]BMK-I-152, a non-peptide analogue for PET imaging of corticotropin-releasing hormone type 1 receptor (CRHR1). J Lab Compounds & Radiopharm. 52(9):394-400.

620. Kaditis AG, Lianou L, Hatzinikolaou S, Kalampouka E, Gartagani-Panayiotopoulou P, Zintzaras E, Chrousos G. (2009) Tonsillar size in 2- to 14-year-old children with and without snoring. Pediatr Pulmonol. 44(12):1216- 22. doi: 10.1002/ppul.21126.

621. Loizou S, Lekakis I, Chrousos GP, Moutsatsou P (2009) beta-Sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells. Mol Nutr Food Res. 2009 Nov 24 [Epub ahead of print]

622. Magiakou MA, Manousaki D, Papadaki M, Hadjidakis D, Levidou G, Vakaki M, Papaefstathiou A, Lalioti N, Kanaka-Gantenbein C, Piaditis G, Chrousos GP, Dacou-Voutetakis C. (2010) The Efficacy and Safety of Gonadotropin-Releasing Hormone Analog Treatment in Childhood and Adolescence: A Single Center, Long- Term Follow-Up Study. J Clin Endocrinol Metab. 95(1):109-17. doi: 10.1210/jc.2009-0793. Epub 2009 Nov 6.

623. Tsaoussoglou M, Bixler EO, Calhoun S, Chrousos GP, Sauder K., Vgontzas AN (2010) Sleep Disordered Breathing in Obese Children is Associated with Prevalent EDS, Inflammation and Metabolic Abnormalities. J Clin Endocrinol Metab. 95(1):143-50. doi: 10.1210/jc.2009-0435. Epub 2009 Nov 19.

624. Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP (2010) Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil Steril. 94(5):1693-9. doi: 10.1016/j.fertnstert.2009.09.049. Epub 2010 Jan 4.

625. Kino T, Hurt DE, Ichijo T, Nader N and Chrousos GP (2010) Noncoding RNA Gas5 is a Growth Arrest and Starvation-associated Repressor for the Glucocorticoid Receptor. Science Signaling, Feb 2;3(107):ra8.

626. Siahanidou T, Margeli A, Davradou M, Apostolakou F, Papassotiriou I, Roma E, Mandyla H, Chrousos G. (2010) Circulating adipocyte fatty acid binding protein levels in healthy preterm infants: Positive correlation with weight gain and total-cholesterol levels. Early Hum Dev. 86(4):197-201. doi: 10.1016/j.earlhumdev.2010.02.008. Epub 2010 Mar 15.

627. Kino T, Jaffe H, Amin ND, Chakrabarti M, Zheng YL, Chrousos GP, Pant HC. (2010) Cyclin-Dependent Kinase 5 Modulates the Transcriptional Activity of the Mineralocorticoid Receptor (MR) and Regulates Expression of Brain-Derived Neurotrophic Factor. Mol Endocrinol.;24(5):941-52. doi: 10.1210/me.2009-0395. Epub 2010 Mar 31.

628. Gazouli M, Pachoula I, Panayotou I, Mantzaris G, Chrousos G, Anagnou NP, Roma-Giannikou E. (2010) NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J Gastroenterol. 6(14):1753-8.

629. Moschovi M, Trimis G, Tsotra M, Chatzi F, Karamolegou K, Santou A, Tourkantoni N, Chrousos G. (2010) Efficacy and safety of linezolid in immunocompromised children with cancer. Pediatr Int. 52(5):694-8. doi: 10.1111/j.1442-200X.2010.03097.x. 54

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630. Pervanidou P, Akalestos A, Sakka S, Kanaka-Gantenbein C, Papassotiriou I, Chrousos GP. (2010) Gender dimorphic associations between N-terminal pro-brain natriuretic peptide, body mass index and blood pressure in children and adolescents. Horm Res Paediatr. 73(5):341-8. Epub 2010 Apr 14.

631. Syrengelas D, Siahanidou T, Kourlaba G, Kleisiouni P, Bakoula C, Chrousos GP (2010) Standardization of the Alberta infant motor scale in full-term Greek infants: Preliminary results. Early Hum Dev. 86(4):245-9. doi: 10.1016/j.earlhumdev.2010.03.009. Epub 2010 May 8.

632. Pejovic S, Vgontzas AN, Basta M, Tsaoussoglou M, Zoumakis E, Vgontzas A, Bixler EO, Chrousos GP. (2010) Leptin and hunger levels in young healthy adults after one night of sleep loss. J Sleep Res. 19(4):552-8. doi: 10.1111/j.1365-2869.2010.00844.x.

633. Nader N, Ng SS, Lambrou GI, Pervanidou P, Wang Y, Chrousos GP, Kino T. (2010) Adenosine 5'- Monophosphate-Activated Protein Kinase Regulates Metabolic Actions of Glucocorticoids by Phosphorylating the Glucocorticoid Receptor through p38 Mitogen-Activated Protein Kinase. Mol Endocrinol. 24: 1748–1764.

634. Al-Attas OS, Al-Daghri NM, Alokail M, Alfadda A, Bamkahramah A, Sabico S, Pritlove D, Harte A, Tripathi G, McTernan P, Kumar S, Chrousos G. (2010) Adiposity and Insulin Resistance Correlate with Telomere Length in Middle-aged Arabs: The Influence of Circulating Adiponectin. Eur J Endocrinol. 163(4):601-7. doi: 10.1530/EJE-10-0241. Epub 2010 Aug 2.

635. Bathrellou E, Yannakoulia M, Papanikolaou K, Pehlivanidis A, Pervanidou P, Kanaka-Gantenbein C, Tokou I, Tsiantis J, Chrousos GP, Sidossis LS. (2010) Parental involvement does not augment the effectiveness of an intense behavioral program for the treatment of childhood obesity. Hormones (Athens). 9(2):171-5.PMID: 20687401 [PubMed - in process]

636. Al-Daghri NM, Al-Attas OS, Al-Okail MS, Alkharfy KM, Al-Yousef MA, Nadhrah HM, Sabico SB, Chrousos GP. (2010) Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults. Saudi Med J. 31 (7): 775-80.

637. Al-Disi D, Al-Daghri N, Khanam L, Al-Othman A, Al-Saif M, Sabico S, Chrousos G (2010) Subjective sleep duration and quality influence diet composition and circulating adipocytokines and ghrelin levels in teen-age girls. Endocr J. 57(10):915-23. doi: 10.1507/endocrj.k10e-145. Epub 2010 Aug 21.

638. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Sabico SL, Chrousos GP. (2010) Decreasing Prevalence of the Full Metabolic Syndrome but a Persistently High Prevalence of Dyslipidemia among Adult Arabs. PLoS One. 5(8). pii: e12159.

639. Chouliaras G, Panayiotou J, Dimakou C, Pachoula J, Orfanou I, Chrousos GP, Roma-Giannikou E. (2010) Biological agents in paediatric inflammatory bowel disease : a clinical observation study from Greece. Acta Gatroenterol Belg. 73: 342-348.

640. Moutsatsou P, Papoutsi Z, Kassi N, Heldring N , Zhao G, Tsiapara A, Melliou E, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K. (2010) Fatty Acids Derived from Royal Jelly Are Modulators of Estrogen Receptor Functions. PLoS ONE 5(12): e15594.

641. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Nadhrah HM, Al-Othman A, Al-Saleh Y, Sabico S, Chrousos GP. (2010) Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Cent Eur J Med 5(6): 752-757.

642. Chouliaras G, Panayiotou J, Dimakou C, Pachoula J, Orfanou I, Chrousos GP, Roma-Giannikou E. (2010) Biological agents in paediatric inflammatory bowel disease: a clinical observation study from Greece. Acta Gastroenterol Belg. 73(3): 342-8.

643. Samara A, Vougas K, Papadopoulou A, Anastasiadou E, Baloyanni N, Paronis E, Chrousos GP, Tsangaris GT. 55

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(2011) Proteomics reveal rat hippocampal lateral asymmetry. Hippocampus. 21(1):108-19. doi: 10.1002/hipo.20727.

644. Naka KK, Kalantaridou SN, Kravariti M, Bechlioulis A, Kazakos N, Calis KA, Makrigiannakis A, Katsouras CS, Chrousos GP, Tsatsoulis A, Michalis LK. (2011) Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: a prospective randomized study. Fertil Steril. 95(1):203-9.

645. Douzinas EE, Betrosian A, Giamarellos-Bourboulis EJ, Tasoulis MK, Prigouris P, Livaditi O, Andrianakis I, Goutas N, Vlachodimitropoulos D, Pelekanou A, Villiotou V, Legakis I, Chrousos GP (2011) Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenuates oxidative response and IL-8 over- expression. Free Radic Biol Med.50(2):245-53. doi: 10.1016/j.freeradbiomed.2010.10.712. Epub 2010 Nov 7.

646. Markopoulos MC, Rizos D, Valsamakis G, Deligeoroglou E, Grigoriou O, Chrousos GP, Creatsas G, Mastorakos G. (2011) Hyperandrogenism in Women with Polycystic Ovary Syndrome Persists after Menopause. J Clin Endocrinol Metab. 96(3):623-31. doi: 10.1210/jc.2010-0130. Epub 2010 Dec 22.

647. Pavlatou MG, Mastorakos G, Margeli A, Kouskouni E, Tentolouris N, Katsilambros N, Chrousos GP, Papassotiriou I. (2011) Angiotensin blockade in diabetic patients decreases insulin resistance-associated low- grade inflammation. Eur J Clin Invest. 41(6):652-8. doi: 10.1111/j.1365-2362.2010.02453.x. Epub 2010 Dec 22.

648. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yakout SM, Sabico SB, Gibson GC, Chrousos GP, Kumar S (2011) Parent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traits. PLoS ONE 6(4): e18182. doi: 10.1371/ journal.pone.0018182.

649. Vasilopoulos Y, Sarafidou T, Bagiatis V, Skriapa L, Goutzelas Y, Pervanidou P, Lazopoulou N, Chrousos GP, Mamuris Z. (2011) Association Between Polymorphisms in MTHFR and APOA5 and Metabolic Syndrome in the Greek Population. Genet Test Mol Biomarkers. 15(9):613-7. doi: 10.1089/gtmb.2010.0256. Epub 2011 Apr 7.

650. Gouli A, Kaltsas G, Tzonou A, Markou A, Androulakis II, Ragkou D, Vamvakidis K, Zografos G, Kontogeorgos G, Chrousos GP, Piaditis G. (2011) High prevalence of autonomous aldosterone secretion among patients with essential hypertension. Eur J Clin Invest. 41(11):1227-36. doi: 10.1111/j.1365- 2362.2011.02531.x. Epub 2011 May 3.

651. Galata Z, Moschonis G, Makridakis M, Dimitraki P, Nicolaides NC, Manios Y, Bartzeliotou A, Chrousos GP and Charmandari E (2011) Plasma proteomic analysis in obese and overweight prepubertal children. Eur J Clin Invest. 41(12):1275-83. doi: 10.1111/j.1365-2362.2011.02536.x. Epub 2011 May 16.

652. Leka S, Kousta E, Anyfandakis K, Dolianiti M, Vakaki M, Linos D, Chrousos GP, Papathanasiou A (2011) Primary pigmented nodular adrenocortical disease: a case report in a 7-year-old girl. J Pediatr Endocrinol Metab. 24(3-4): 197-202.

653. Al-Daghri NM, Al-Attas OS, Majed S. Alokail MS, Alkharfy KM, Yousef M, Sabico SL, Chrousos GP (2011) Diabetes Mellitus Type 2 and other Chronic Non-communicable Diseases in the Central Region, Saudi Arabia (Riyadh Cohort 2): A Decade of an Epidemic. BMC Med. 9:76. doi: 10.1186/1741-7015-9-76.

654. Malakasioti G, Gourgoulianis K, Chrousos G, and Kaditis A (2011) Interactions of Obstructive Sleep- disordered Breathing with Recurrent Wheezing or Asthma and their Effects on Sleep Quality. Pediatr Pulmonol. 46(11):1047-54. doi: 10.1002/ppul.21497.

655. Spoulou V, Kanaka-Gantenbein C, Bathrellou I, Mora S, Mostrou G, Sidossis L, Chrousos G, Theodoridou M. (2011) Monitoring of Lipodystrophic and Metabolic Abnormalities in HIV-1 Infected Children on Antiretroviral Therapy. Hormones (Athens). 10 (2):149-55.

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656. Michos A, Tzanoudaki M, Villa A, Giliani S, Chrousos G, Kanariou M. (2011) Severe Combined Immunodeficiency in Greek Children over a 20-Year Period: Rarity of γ(c)-Chain Deficiency (X-Linked) Type. J Clin Immunol. 31(5):778-83. doi: 10.1007/s10875-011-9564-0. Epub 2011 Jul 6.

657. Kolaitis G, Giannakopoulos G, Liakopoulou M, Pervanidou P, Charitaki S, Mihas C, Ferentinos S, Papassotiriou I, Chrousos GP, Tsiantis J. (2011) Predicting pediatric posttraumatic stress disorder after road traffic accidents: The role of parental psychopathology. J Trauma Stress. 24(4):414-21. doi: 10.1002/jts.20667. Epub 2011 Aug 2.

658. Karamouzis I, Pervanidou P, Berardelli R, Iliadis S, Papassotiriou I, Karamouzis M, Chrousos GP , Kanaka- Gantenbein C (2011) Enhanced Oxidative Stress and Platelet Activation Combined with Reduced Antioxidant Capacity in Obese Prepubertal and Adolescent Girls with Full or Partial Metabolic Syndrome. Horm Metab Res 43: 607–613.

659. Andreou, E.; Alexopoulos, E.C.; Lionis, C.; Varvogli, L.; Gnardellis, C.; Chrousos, G.P.; Darviri, C. (2011) Perceived Stress Scale: Reliability and Validity Study in Greece. Int J Environ Res Public Health. 8(8):3287- 98. doi: 10.3390/ijerph8083287. Epub 2011 Aug 11.

660. Pogka V, Kossivakis A, Kalliaropoulos A, Moutousi A, Sgouras D, Panagiotopoulos T, Chrousos GP, Theodoridou M, Syriopoulou VP, Mentis AF. (2011) Respiratory viruses involved in influenza-like illness in a Greek pediatric population during the winter period of the years 2005-2008. J Med Virol. 83(10):1841-8. doi: 10.1002/jmv.22173.

661. Tigani X, Artemiadis AK, Alexopoulos EC, Chrousos GP, Darviri C (2011) Gender differences in Greek centenarians. A cross-sectional nationwide study, examining multiple socio-demographic and personality factors and health locus of control. BMC Geriatr. 11:87. doi: 10.1186/1471-2318-11-87.

662. Jacobsson JA, Rask-Andersen M, Risérus U, Moschonis G, Koumpitski A, Chrousos GP, Lannfelt L, Marcus C, Gyllensten U, Schiöth HB, Fredriksson R. (2012) Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children. Int J Obes (Lond). 36(1):119-29. doi: 10.1038/ijo.2011.11. Epub 2011 Feb 8.

663. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, El-Kholie E, Yousef M, Al-Othman A, Al-Saleh Y, Sabico S, Kumar S, Chrousos GP. (2012) Increased Vitamin D Supplementation Recommended during Summer Season in the Gulf Region: A Counterintuitive Seasonal Effect in Vitamin D Levels in Adult, Overweight and Obese Middle-eastern Residents. Clin Endocrinol (Oxf). 76(3):346-50. doi: 10.1111/j.1365- 2265.2011.04219.x.

664. Rask-Andersen M, Jacobsson JA, Moschonis G, Chavan RA, Sikder MA, Allzén E, Alsiö J, Chrousos GP, Manios Y, Fredriksson R, Schiöth HB. (2012) Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet. 20(2):192-7. doi: 10.1038/ejhg.2011.176. Epub 2011 Sep 28.

665. Charmandari E, Chrousos GP, Lambrou GI, Pavlaki A, Koide H, Ng SSM and Kino T (2011) Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man. PLoS One. 6(9):e25612. doi: 10.1371/journal.pone.0025612. Epub 2011 Sep 28.

666. Zannas AS, McQuoid DR, Steffens DC, Chrousos GP, Taylor WD. (2012) Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158met polymorphisms. Stress. 15(4):425-34. doi: 10.3109/10253890.2011.634263. Epub 2012 Jan 4.

667. Al-Daghri NM, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS, Al-Othman A, Moharram O, El-Kholie E, Sabico S, Kumar S, Chrousos GP. (2012) Modest reversal of metabolic syndrome manifestations with vitamin D status correction: a 12-month prospective study. Metabolism. 61(5):661-6. doi: 10.1016/j.metabol.2011.09.017. Epub 2011 Nov 8. 57

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668. Moschonis G, Chrousos GP, Lionis C, Mougios V, Manios Y. (2012) Association of total body and visceral fat mass with iron deficiency in preadolescents: the Healthy Growth Study. Br J Nutr. 108(4):710-9. doi: 10.1017/S0007114511005952. Epub 2011 Nov 16.

669. Fragiadaki K, Tektonidou MG, Konsta M, Chrousos GP, Sfikakis PP. (2012) Sleep Disturbances and Interleukin 6 Receptor Inhibition in Rheumatoid Arthritis. J Rheumatol. 39(1):60-2. doi: 10.3899/jrheum.110617. Epub 2011 Dec 1.

670. Vgontzas AN, Fernandez-Mendoza J, Bixler EO, Singareddy R, Shaffer ML, Calhoun SL, Liao D, Basta M, Chrousos GP (2012) Persistent insomnia: the role of objective short sleep duration and mental health. Sleep. 35(1):61-8. doi: 10.5665/sleep.1586.

671. Almén MS, Jacobsson JA, Moschonis G, Benedict C, Chrousos GP, Fredriksson R, Schiöth HB. (2012) Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics. 99(3):132-7. doi: 10.1016/j.ygeno.2011.12.007. Epub 2012 Jan 2.

672. Tsartsali L, Papadopoulos M, Lagona E, Papadimitriou A, Kanaka-Gantenbein C, Louizou E, Kastania A, Priftis KN, Chrousos G (2012) Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in asthmatic children on inhaled corticosteroids. Neuroimmunomodulation. 19(2):88-95. doi: 10.1159/000329592.

673. Lambrou GI, Papadimitriou L, Chrousos GP, Vlahopoulos SA. (2012) Glucocorticoid and proteasome inhibitor impact on the leukemic lymphoblast: Multiple, diverse signals converging on a few key downstream regulators. Mol Cell Endocrinol. 351(2):142-51. doi: 10.1016/j.mce.2012.01.003.

674. Al-Musharaf S, Al-Othman A, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, Al-Saleh Y, Al- Attas OS, Alokail MS, Moharram O, Yakout S, Sabico S, Chrousos GP (2012) Vitamin D deficiency and calcium intake in reference to increased body mass index in children and adolescents. Eur J Pediatr. 171(7):1081-6. doi: 10.1007/s00431-012-1686-8. Epub 2012 Feb 7.

675. Tigani X, Artemiadis AK, Alexopoulos EC, Chrousos GP, Darviri C. (2012) Self-rated health in centenarians: A nation-wide cross-sectional Greek study. Arch Gerontol Geriatr. 54(3):e342-8. doi: 10.1016/j.archger.2012.01.012. Epub 2012 Feb 22.

676. Nader N, Ng SSM, Wang Y, Abel BS, Chrousos GP, Kino T (2012) Liver X Receptors Regulate the Transcriptional Activity of the Glucocorticoid Receptor: Implications for the Carbohydrate Metabolism. PLoS One. 7(3):e26751. doi: 10.1371/journal.pone.0026751. Epub 2012 Mar 22.

677. Androutsos O, Grammatikaki E, Moschonis G, Roma-Giannikou E, Chrousos GP, Manios Y, Kanaka- Gantenbein C. (2012) Neck circumference: a useful screening tool of cardiovascular risk in children. Pediatr Obes. 7(3):187-95. doi: 10.1111/j.2047-6310.2012.00052.x. Epub 2012 Apr 13.

678. Alfadda AA, Sallam RM, Chishti MA, Moustafa AS, Fatma S, Alomaim WS, Al-Naami MY, Bassas AF, Chrousos GP, Jo H. (2012) Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: Adipose depot specificity and gender dimorphism. Mol Cells. 33(6):591-6. doi: 10.1007/s10059-012-0012-7. Epub 2012 Apr 27.

679. Rask-Andersen M, Jacobsson JA, Moschonis G, Ek AE, Chrousos GP, Marcus C, Manios Y, Fredriksson R, Schiöth HB. (2012) The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children. BMC Med Genet. 13:36. doi: 10.1186/1471-2350-13-36.

680. Al-Attas O, Al-Daghri N, Alokail M, Alkharfy K, Alfadda A, McTernan P, Gibson G, Sabico S, Chrousos G. (2012) Circulating leukocyte telomere length is highly heritable among families of Arab descent. BMC Med Genet. 13(1):38. [Epub ahead of print]

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681. Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP. (2012) A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant Hypertension. J Clin Endocrinol Metab. 97(8):E1532-9. doi: 10.1210/jc.2012-1334. Epub 2012 May 24.

682. Tsaoussoglou M, Lianou L, Maragozidis P, Hatzinikolaou S, Mavromati M, Orologas N, Panaghiotopoulou- Gartagani P, Rassidakis G, Balatsos NA, Chrousos G, Kaditis AG. (2012) Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea. Sleep Med. 13(7):879-85. doi: 10.1016/j.sleep.2012.03.010. Epub 2012 May 28.

683. Johnson EO, Calogero AE, Konstandi M, Kamilaris TC, La Vignera S, Chrousos GP (2012) Effects of short- and long-duration hypothyroidism on hypothalamic-pituitary-adrenal axis function in rats: In vitro and in situ studies. Endocrine. 42(3):684-93. doi: 10.1007/s12020-012-9714-z. Epub 2012 Jun 14.

684. Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, Imura A, Nabeshima YI, Chrousos G (2012) Plasma soluble α-Klotho protein levels in premature and term neonates: Correlations with growth and metabolic parameters. Eur J Endocrinol. 167(3):433-40. doi: 10.1530/EJE-12-0476. Epub 2012 Jun 19.

685. Al-Othman A, Al-Musharaf S, Al-Daghri N, Krishnaswamy S, Yusuf D, Alkharfy K, Al-Saleh Y, Al-Attas O, Alokail M, Moharram O, Sabico S, Chrousos G. (2012) Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents.BMC Pediatr. 12:92. doi: 10.1186/1471-2431-12-92.

686. Al-Daghri NM, Alkharfy KM, Al-Othman A, El-Kholie E, Moharram O, Alokail MS, Al-Saleh Y, Sabico S, Kumar S, Chrousos G (2012) Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study. Cardiovasc Diabetol. 11:85. doi: 10.1186/1475-2840-11-85.

687. Al-Daghri NM, Al-Othman A, Alkharfy KM, Alokail MS, Khan N, Alfawaz HA, Aiswaidan IA, Chrousos GP. (2012) Assessment of selected nutrients intake and adipocytokines profile among Saudi children and adults. Endocr J. 59(12):1057-63. doi: 10.1507/endocrj.ej12-0167. Epub 2012 Jul 13.

688. Al-Attas OS, Al-Daghri NM, Alokail MS, Alkharfy KM, Yakout S, Draz H, Sabico S, Chrousos GP (2012) Association of body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and adipocytokines in arab children and adolescents. BMC Pediatr. 12:119. doi: 10.1186/1471-2431-12- 119.

689. Spyridopoulos TN, Dessypris N, Antoniadis AG, Gialamas S, Antonopoulos CN, Katsifoti K, Adami HO, Chrousos GP, Petridou ET, Obesity and Cancer Oncology Group; (2012) Insulin resistance and risk of renal cell cancer: a case-control study. Hormones (Athens). 11(3): 308-15.

690. Al-Othman A, Al-Musharaf S, Al-Daghri NM, Yakout S, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS, Moharram O, Sabico S, Kumar S, Chrousos GP (2012) Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents. Nutr J. 11:56. doi: 10.1186/1475-2891-11-56.

691. Al-Daghri NM, Al-Attas OS, Bindahman LS, Alokail MS, Alkharfy KM, Draz HM, Yakout S, McTernan PG, Sabico S, Chrousos GP (2012) Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients. Eur J Clin Invest. 42(11):1221-6.

692. Papanastasiou L, Pappa T, Samara C, Apostolopoulou G, Tsiavos V, Markou A, Alexandraki K, Piaditis G, Chrousos G, Kaltsas G. (2012) Nonalcoholic fatty liver disease in subjects with adrenal incidentaloma. Eur J Clin Invest. 42(11):1165-72. doi: 10.1111/j.1365-2362.2012.02707.x. Epub 2012 Aug 1.

693. Gika DM, Artemiadis AK, Alexopoulos EC, Darviri C, Chrousos GP, Papanikolaou K. (2012) Use of a relaxation technique by mothers of children with autism: a case-series study. Psychol Rep. 111(3):797-804. doi: 10.2466/20.15.21.PR0.111.6.797-804.

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694. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Al-Othman A, Draz HM, Yakout SM, Al-Saleh Y, Al-Yousef M, Sabico S, Clerici M, Chrousos GP. (2013) Hypovitaminosis D Associations with Adverse Metabolic Parameters Are Accentuated in Patients with Diabetes Mellitus Type 2: A BMI-Independent Role of Adiponectin? J Endocrinol Invest. 36(1):1-6. doi: 10.3275/8183.

695. Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB. (2013) Determination of the obesity-associated gene variants within the entire FTO gene by ultra- deep targeted sequencing in obese and lean children. Int J Obes (Lond). 37(3):424-31. doi: 10.1038/ijo.2012.57. Epub 2012 Apr 24.

696. Pervanidou P, Bastaki D, Chouliaras G, Papanikolaou K, Laios E, Kanaka-Gantenbein C, Chrousos GP. (2013) Circadian cortisol profiles, anxiety and depressive symptomatology, and body mass index in a clinical population of obese children. Stress. 16(1):34-43. doi: 10.3109/10253890.2012.689040. Epub 2012 Jun 4.

697. Moschonis G, Mavrogianni C, Karatzi K, Iatridi V, Chrousos GP, Lionis C, Manios Y (2013) Increased physical activity combined with more eating occasions is beneficial against dyslipidemias in children. The Healthy Growth Study. Eur J Nutr. 52(3):1135-44. doi: 10.1007/s00394-012-0424-3. Epub 2012 Aug 7.

698. Papaioannou G, Kambas I, Tsaoussoglou M, Panaghiotopoulou-Gartagani P, Chrousos G, Kaditis AG. (2013) Age-Dependent Changes in the Size of Adenotonsillar Tissue in Childhood: Implications for Sleep-Disordered Breathing. J Pediatr. 162(2):269-74.e4. doi: 10.1016/j.jpeds.2012.07.041. Epub 2012 Aug 30

699. Johnson EO, Kamilaris TC, Calogero AE, Konstandi M, Chrousos GP. (2013) Effects of Short- and Long- Duration Hypothyroidism on Function of the Rat Hypothalamic-Pituitary-Adrenal Axis. J Endocrinol Invest. 36(2):104-10. doi: 10.3275/8454. Epub 2012 Jun 18.

700. Kritikou I, Basta M, Tappouni R, Pejovic S, Fernandez-Mendoza J, Nazir R, Shaffer M, Liao D, Bixler E, Chrousos G, Vgontzas AN. (2013) Sleep apnoea and visceral adiposity in middle-aged males and females. Eur Respir J. 41(3):601-9. doi: 10.1183/09031936.00183411. Epub 2012 Jun 27.

701. Al-Saleh Y, Al-Daghri NM, Alkharfy KM, Al-Attas OS, Alokail MS, Al-Othman A, Sabico S, Chrousos GP (2013) Normal Circulating PTH in Saudi Healthy Individuals with Hypovitaminosis D. Horm Metab Res. 45(1):43-6. doi: 10.1055/s-0032-1323679. Epub 2012 Sep 12.

702. Johnson EO, Calogero AE, Konstandi M, Kamilaris TC, Vignera SL, Chrousos GP (2013) Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: in vitro and in situ studies. Pituitary. 16(2):275-86. doi: 10.1007/s11102-012-0417-5.

703. Androutsellis-Theotokis A, Chrousos GP, McKay RD, Decherney AH, Kino T. (2013) Expression Profiles of the Nuclear Receptors and Their Transcriptional Coregulators During Differentiation of Neural Stem Cells. Horm Metab Res. 45(2):159-68. doi: 10.1055/s-0032-1321789. Epub 2012 Sep 18.

704. Kouni S, Karakitsos P, Chranioti A, Theodoridou M, Chrousos G, Michos A. (2013) Evaluation of viral co- infections in hospitalized and non-hospitalized children with respiratory infections using microarrays. Clin Microbiol Infect. 19(8):772-7. doi: 10.1111/1469-0691.12015. Epub 2012 Oct 1.

705. Aravidou E, Tsangaris G, Samara A, Dontas I, Botsis D, Aravidis C, Chrousos GP, Malamitsi-Puchner A. (2013) Aberrant Expression of Collapsin Response Mediator Proteins -1, -2 and -5 in the Brain of Intrauterine Growth Restricted Rats. Int J Dev Neurosci. 31(1):53-60. doi: 10.1016/j.ijdevneu.2012.10.004. Epub 2012 Oct 18.

706. Pervanidou P, Akalestos A, Bastaki D, Apostolakou F, Papassotiriou I, Chrousos G. (2013) Increased circulating High-Sensitivity Troponin T concentrations in children and adolescents with obesity and the metabolic syndrome: A marker for early cardiac damage? Metabolism. 62(4):527-31. doi: 10.1016/j.metabol.2012.09.012. Epub 2012 Oct 29. 60

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707. Dinopoulou V, Partsinevelos GA, Mavrogianni D, Anagnostou E, Drakakis P, Makrigiannakis A, Chrousos GP, Loutradis D. (2013) The Effect of CRH and Its Inhibitor, Antalarmin, on in Vitro Growth of Preantral Mouse Follicles, Early Embryo Development, and Steroidogenesis. Endocrinology. 154(1):222-31. doi: 10.1210/en.2012-1838. Epub 2012 Dec 4.

708. Sertedaki A, Dracopoulou M, Voutetakis A, Stefanaki K, Rodogianni D, Magiakou AM, Kanaka-Gantenbein C, Chrousos G, Dacou-Voutetakis C. (2013) Long-term Clinical Data and Molecular Defects in the StAR Gene in Five Greek Patients. Eur J Endocrinol. 168(3):351-9. doi: 10.1530/EJE-12-0600.

709. Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, Tzotzola V, Skenderi KP, Petridou A, Tsalis G, Sakellaropoulou A, Skouli G, Katsarou C. (2013) The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet. 26(5):470-8. doi: 10.1111/jhn.12025. Epub 2012 Dec 30.

710. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Charalampidis P, Livadas S, Kollias A, Sabico SL, Chrousos GP. (2013) Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances. Eur J Clin Invest. 43(2):183-9. doi: 10.1111/eci.12030. Epub 2012 Dec 20.

711. Manios Y, Birbilis M, Moschonis G, Birbilis G, Mougios V, Lionis C, Chrousos GP; on behalf of the “Healthy Growth Study” group. (2013) Childhood Obesity Risk Evaluation based on perinatal factors and family sociodemographic characteristics: CORE Index. Eur J Pediatr. 172(4):551-5. doi: 10.1007/s00431-012-1918-y. Epub 2013 Jan 10.

712. Sarra A, Karantza M, Papaefthymiou M, Soultanakis H, Papaefstathiou A, Nikolaidou P, Bakoula C, Chrousos G. (2013) Influence of developmental and hormonal factors on bone health in adolescent females: a cross- sectional study and review of the literature. J Pediatr Endocrinol Metab. 26(3-4):239-46. doi: 10.1515/jpem- 2012-0355.

713. Alokail MS, Al-Daghri N, Abdulkareem A, Draz HM, Yakout SM, Alnaami AM, Sabico S, Alenad AM, Chrousos GP. (2013) Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? BMC Cancer. 13:54. doi: 10.1186/1471-2407-13-54.

714. Settas N, Dracopoulou-Vabouli M, Dastamani A, Katsikis I, Chrousos G, Panidis D, Dacou-Voutetakis C (2013) CYP21A2 Mutations in Women with Polycystic Ovary Syndrome (PCOS). Horm Metab Res. 45(5):383-6. doi: 10.1055/s-0033-1333727. Epub 2013 Feb 5.

715. Roberts ML, Kino T, Nicolaides NC, Hurt DE, Katsantoni E, Sertedaki A, Komianou F, Kassiou K, Chrousos GP, Charmandari E. (2013) A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its DBD. J Clin Endocrinol Metab. 98(4):E790-5. doi: 10.1210/jc.2012-3549. Epub 2013 Feb 20.

716. Bougea AM, Spandideas N, Alexopoulos EC, Thomaides T, Chrousos GP, Darviri C. (2013) Effect of the emotional freedom technique on perceived stress, quality of life, and cortisol salivary levels in tension-type headache sufferers: a randomized controlled trial. Explore (NY). 9(2):91-9.

717. Giannouli G, Tzoumaka-Bakoula C, Kopsidas I, Papadogeorgou P, Chrousos GP, Michos A. (2013) Epidemiology and Risk Factors for Coronary Artery Abnormalities in Children With Complete and Incomplete Kawasaki Disease During a 10-Year Period. Pediatr Cardiol. 34(6):1476-81. doi: 10.1007/s00246-013-0673-9.

718. Markou A, Pappa T, Kaltsas G, Gouli A, Mitsakis K, Tsounas P, Prevoli A, Tsiavos V, Papanastasiou L, Zografos G, Chrousos GP, Piaditis GP. (2013) Evidence of Primary Aldosteronism in a Predominantly Female Cohort of Normotensive Individuals: A Very High Odds Ratio for Progression into Arterial Hypertension. J Clin Endocrinol Metab. 98(4):1409-16. 61

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719. Tatsi C, Sertedaki A, Voutetakis A, Valavani E, Magiakou MA, Kanaka-Gantenbein C, Chrousos GP, Dacou- Voutetakis C. (2013) Pituitary Stalk Interruption Syndrome and Isolated Pituitary Hypoplasia May Be Caused by Mutations in Holoprosencephaly-Related Genes. J Clin Endocrinol Metab. 98(4):E779-84. doi: 10.1210/jc.2012-3982. Epub 2013 Mar 8.

720. Sakka SD, Margeli A, Loutradis D, Chrousos GP, Papassotiriou I, Kanaka-Gantenbein C. (2013) Gender dimorphic increase in RBP-4 and NGAL in children born after IVF: an epigenetic phenomenon? Eur J Clin Invest. 43(5):439-48. doi: 10.1111/eci.12066. Epub 2013 Mar 15.

721. Tatsi C, Kanaka-Gantenbein C, Vazeou-Gerassimidi A, Chrysis D, Delis D, Tentolouris N, Dacou-Voutetakis C, Chrousos GP, Sertedaki A. (2013) The spectrum of HNF1A gene mutations in Greek patients with MODY3: relative frequency and identification of seven novel germline mutations. Pediatr Diabetes. 14(7):526-34. doi: 10.1111/pedi.12032. Epub 2013 Mar 21.

722. Manti P, Giannakopoulos G, Giouroukou E, Georgaki-Angelaki H, Stefanidis CJ, Mitsioni A, Stergiou N, Mihas C, Chrousos GP, Magiakou MA, Kolaitis G. (2013) Psychosocial and cognitive function in children with nephrotic syndrome: association with disease and treatment variables. Biopsychosoc Med. 7(1):10. doi: 10.1186/1751-0759-7-10.

723. Christaki E, Kokkinos A, Costarelli V, Alexopoulos EC, Chrousos GP, Darviri C. (2013) Stress management can facilitate weight loss in Greek overweight and obese women: a pilot study. J Hum Nutr Diet. 26 Suppl 1:132-9.

724. Bahijri S, Borai A, Ajabnoor G, Abdul Khaliq A, Alqassas I, Al-Shehri D, Chrousos G. (2013) Relative Metabolic Stability, but Disrupted Circadian Cortisol Secretion during the Fasting Month of Ramadan. PLoS One. 8(4):e60917. doi: 10.1371/journal.pone.0060917. Print 2013.

725. Moschonis G, Mougios V, Papandreou C, Lionis C, Chrousos GP, Malandraki E, Manios Y. (2013) "Leaner and less fit" children have a better cardiometabolic profile than their "heavier and more fit" peers: The Healthy Growth Study. Nutr Metab Cardiovasc Dis. 23(11):1058-65. doi: 10.1016/j.numecd.2012.11.010. Epub 2013 May 13.

726. Dimitriadou E, Noutsopoulos D, Markopoulos G, Vlaikou AM, Mantziou S, Traeger-Synodinos J, Kanavakis E, Chrousos GP, Tzavaras T, Syrrou M. (2013) Abnormal DLK1/MEG3 imprinting correlates with decreased HERV-K methylation after assisted reproduction and preimplantation genetic diagnosis. Stress. 16(6):689-97. doi: 10.3109/10253890.2013.817554. Epub 2013 Jul 25.

727. Karatzas T, Vasileiadis I, Kapetanakis S, Karakostas E, Chrousos G, Kouraklis G. (2013) Risk factors contributing to the difference in prognosis for papillary versus micropapillary thyroid carcinoma. Am J Surg. 206(4):586-93. doi: 10.1016/j.amjsurg.2013.02.008. Epub 2013 Jun 19.

728. Christaki E, Kokkinos A, Costarelli V, Alexopoulos EC, Chrousos GP, Darviri C. (2013) Stress management can facilitate weight loss in Greek overweight and obese women: a pilot study. J Hum Nutr Diet. 26 Suppl 1:132-9. doi: 10.1111/jhn.12086. Epub 2013 Apr 30.

729. Chouliaras G, Panayotou I, Margoni D, Mantzou E, Pervanidou P, Manios Y, Chrousos GP, Roma E. (2013) Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn's disease and ulcerative colitis. Pediatr Res. 74(4):420-6. doi: 10.1038/pr.2013.114. Epub 2013 Jul 3.

730. Tzifi F, Kanariou M, Tzanoudaki M, Mihas C, Paschali E, Chrousos G, Kanaka-Gantenbein C. (2013) Flow cytometric analysis of the CD4+ TCR Vbeta repertoire in the peripheral blood of children with type 1 diabetes mellitus, systemic lupus erythematosus and age-matched healthy controls. BMC Immunol. 3;14:33. doi: 10.1186/1471-2172-14-33.

731. Al-Kharfy K, Al-Daghri N, Sabico S, Al-Othman A, Moharram O, Alokail M, Al-Saleh Y, Kumar S, Chrousos 62

George P. Chrousos, M.D.

G. (2013) Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective study. Cardiovasc Diabetol. 12:113. doi: 10.1186/1475-2840-12-113.

732. Papatheodorou DC, Karagiannidis LK, Paltoglou G, Margeli A, Kaparos G, Valsamakis G, Chrousos GP, Creatsas G, Mastorakos G. (2013) Pulsatile interleukin-6 leads CRH secretion and is associated to myometrial contractility during the active phase of term human labor. J Clin Endocrinol Metab. 98(10):4105-12. doi: 10.1210/jc.2012-4023. Epub 2013 Aug 8.

733. Krikri A, Alexopoulos V, Zoumakis E, Katsaronis P, Balafas E, Kouraklis G, Karayannacos PE, Chrousos GP, Skalkeas G. (2013) Laparoscopic vs. open abdominal surgery in male pigs: Marked differences in cortisol and catecholamine response depending on the size of surgical incision. Hormones (Athens). 12(2):283-91. doi: 10.14310/horm.2002.1412.

734. Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO, Chrousos GP. (2013) The Effects of Recovery Sleep after One Workweek of Mild Sleep Restriction on Interleukin-6 and Cortisol Secretion and Daytime Sleepiness and Performance. Am J Physiol Endocrinol Metab. 305(7):E890-6. doi: 10.1152/ajpendo.00301.2013. Epub 2013 Aug 13.

735. Rask-Andersen M, Moschonis G, Chrousos GP, Marcus C, Dedoussis GV, Fredriksson R, Schiöth HB. (2013) The STK33-Linked SNP rs4929949 Is Associated with Obesity and BMI in Two Independent Cohorts of Swedish and Greek Children. PLoS One. 8(8):e71353. doi: 10.1371/journal.pone.0071353. eCollection 2013.

736. Xekouki P, Mastroyiannis SA, Avgeropoulos D, de la Luz Sierra M, Trivellin G, Gourgari EA, Lyssikatos C, Quezado M, Patronas N, Kanaka-Gantenbein C, Chrousos GP, Stratakis CA. (2013) Familial pituitary apoplexy as the only presentation of a novel AIP mutation. Endocr Relat Cancer. 20(5):L11-4. doi: 10.1530/ERC-13-0218.

737. Gialamas SP, Sergentanis TN, Antonopoulos CN, Dessypris N, Chrousos GP, Petridou ET. (2013) Circulating leptin levels and risk of colorectal cancer and adenoma: a case-control study and meta-analysis. Cancer Causes Control. 24(12):2129-41. doi: 10.1007/s10552-013-0290-1. Epub 2013 Oct 2.

738. Metheniti D, Sakka S, Dracopoulou M, Margeli A, Papassotiriou I, Kanaka-Gantenbein C, Chrousos GP, Pervanidou P. (2013) Decreased circulating 25-(OH) Vitamin D concentrations in obese female children and adolescents: Positive associations with Retinol Binding Protein-4 and Neutrophil Gelatinase-associated Lipocalin. Hormones (Athens). 12(3):397-404. doi: 10.1007/BF03401305.

739. Alexopoulos EI; Theologi V; Malakasioti G; Maragozidis P; Tsilioni I; Chrousos G; Gourgoulianis K; Kaditis AG. (2013) Obstructive sleep apnea, excessive daytime sleepiness, and morning plasma TNF-α levels in Greek children. Sleep. 36 (11):1633-1638.

740. Giannaki M, Kakourou T, Theodoridou M, Syriopoulou V, Kabouris M, Louizou E, Chrousos G. (2013) Human Papillomavirus (HPV) Genotyping of Cutaneous Warts in Greek Children. Pediatr Dermatol. 30(6):730-5. doi: 10.1111/pde.12113. Epub 2013 Apr 4.

741. Moschonis G, Papandreou D, Mavrogianni C, Giannopoulou A, Damianidi L, Malindretos P, Lionis C, Chrousos GP, Manios Y. (2013) Association of iron depletion with menstruation and dietary intake indices in pubertal girls: the healthy growth study. Biomed Res Int. 2013:423263. doi: 10.1155/2013/423263. Epub 2013 Dec 23.

742. Balfoussia E, Skenderi K, Tsironi M, Anagnostopoulos AK, Parthimos N, Vougas K, Papassotiriou I, Tsangaris GT, Chrousos GP. (2014) A Proteomic Study of Plasma Protein Changes Under Extreme Physical Stress. J Proteomics. 98:1-14. doi: 10.1016/j.jprot.2013.12.004. Epub 2013 Dec 15.

743. Katsarou AL, Vryonis MM, Protogerou AD, Alexopoulos EC, Achimastos A, Papadogiannis D, Chrousos GP, Darviri C. (2014) Stress management and dietary counseling in hypertensive patients: a pilot study of additional effect. Prim Health Care Res Dev. 15(1):38-45. 63

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744. Moschonis G, Kalliora AC, Costarelli V, Papandreou C, Koutoukidis D, Lionis C, Chrousos GP, Manios Y. (2014) Identification of lifestyle patterns associated with obesity and fat mass in children: the Healthy Growth Study. Public Health Nutr. 17(3):614-24. doi: 10.1017/S1368980013000323. Epub 2013 Mar 26.

745. Kritikou I, Basta M, Vgontzas AN, Pejovic S, Liao D, Tsaoussoglou M, Bixler E, Stefanakis Z, Chrousos G. (2014) Sleep Apnea, Sleepiness, Inflammation and Insulin Resistance in middle-aged Men and Women. Eur Respir J. 43(1):145-55.

746. Kalampouka E, Moudaki A, Malakasioti G, Panaghiotopoulou-Gartagani P, Chrousos G, Kaditis AG. (2014) Family history of adenotonsillectomy as a risk factor for tonsillar hypertrophy and snoring in childhood. Pediatr Pulmonol. 49(4):366-71. doi: 10.1002/ppul.22830. Epub 2013 Jun 17.

747. Miranda J, Romero R, Korzeniewski SJ, Chaemsaithong P, Stampalija T, Yeo L, Dong Z, Hassan SS, Chrousos GP, Gold P, Chaiworapongsa T. (2014) The Anti-aging Factor α-klotho during Human Pregnancy and its Expression in Pregnancies Complicated by Small for Gestational Age Neonates and/or Preeclampsia. J Matern Fetal Neonatal Med. 27(5):449-57. doi: 10.3109/14767058.2013.818652. Epub 2013 Aug 19.

748. Kalaitzidou I, Venetikou MS, Konstadinidis K, Artemiadis AK, Chrousos G, Darviri C. (2014) Stress management and erectile dysfunction: a pilot comparative study. Andrologia. 46(6):698-702. doi: 10.1111/and.12129. Epub 2013 Jul 3.

749. Papastamataki M, Papassotiriou I, Bartzeliotou A, Vazeou A, Roma E, Chrousos GP, Kanaka-Gantenbein C. (2014) Incretins, Amylin and Other Gut-Brain Axis Hormones in Children with Celiac Disease. Eur J Clin Invest. 44(1):74-82. doi: 10.1111/eci.12193. Epub 2013 Nov 14.

750. Al-Daghri NM, Alkharfy KM, Rahman S, Amer OE, Vinodson B, Sabico S, Milan P, Harte AL, McTernan PG, Alokail MS, Chrousos GP. (2014) Irisin as a Predictor of Glucose Metabolism in Children: Sexually Dimorphic Effects. Eur J Clin Invest. 44(2):119-24. doi: 10.1111/eci.12196. Epub 2013 Dec 6.

751. Alexopoulos A, Kakourou T, Orfanou I, Xaidara A, Chrousos G. (2014) Retrospective Analysis of the Relationship Between Infantile Seborrheic Dermatitis and Atopic Dermatitis. Pediatr Dermatol. 31(2):125-30. doi: 10.1111/pde.12216. Epub 2013 Nov 13.

752. Androutsos O, Moschonis G, Koumpitski A, Mantzou A, Roma-Giannikou E, Chrousos GP, Manios Y, Kanaka-Gantenbein C; on behalf of the “Healthy Growth Study” Group. (2014) The correlation of right 2D:4D finger length ratio to the low-grade inflammation marker IL-6 in children. The Healthy Growth Study. Early Hum Dev. 90(1):61-5. doi: 10.1016/j.earlhumdev.2013.10.003. Epub 2013 Nov 15.

753. Theodoridou K, Margeli A, Spoulou V, Bathrellou I, Skevaki C, Chrousos GP, Papassotiriou I, Kanaka- Gantenbein C. (2014) Non-traditional adipokines in pediatric HIV-related lipodystrophy: a-FABP as a biomarker of central fat accumulation. Scand J Clin Lab Invest. 74(1):67-73.

754. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Vinodson B, Amer OE, Alnaami AM, Sabico S, Tripathi G, Piya MK, McTernan PG, Chrousos GP. (2014) Maternal inheritance of circulating irisin in humans. Clin Sci (Lond). 126(12):837-44. doi: 10.1042/CS20130426.

755. Androutsos O, Moschonis G, Mavrogianni C, Roma-Giannikou E, Chrousos GP, Kanaka-Gantenbein C, Manios Y. (2014) Identification of lifestyle patterns, including sleep deprivation, associated with insulin resistance in children: the Healthy Growth Study. Eur J Clin Nutr. 68(3):344-9. doi: 10.1038/ejcn.2013.280. Epub 2014 Jan 15.

756. Al-Daghri NM, Alkharfy KM, Al-Attas OS, Krishnaswamy S, Mohammed AK, Albagha OM, Alenad AM, Chrousos GP, Alokail MS. (2014) Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population. Mol Biol Rep. 41(3):1731-40. doi: 10.1007/s11033-014-3022-z. Epub 2014 Jan 17. 64

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757. Leka-Emiri S, Louizou E, Kambouris M, Chrousos G, De Roux N, Kanaka-Gantenbein C. (2014) Absence of GPR54 and TACR3 Mutations in Sporadic Cases of Idiopathic Central Precocious Puberty. Horm Res Paediatr. 81(3):177-81. doi: 10.1159/000356913. Epub 2014 Jan 10.

758. Settas N, Dacou-Voutetakis C, Karantza M, Kanaka-Gantenbein C, Chrousos GP, Voutetakis A. (2014) Central Precocious Puberty in a Girl and Early Puberty in her Brother Caused by a Novel Mutation in the MKRN3 Gene. J Clin Endocrinol Metab. 99(4):E647-51. doi: 10.1210/jc.2013-4084. Epub 2014 Jan 17.

759. Karatzi K, Moschonis G, Barouti AA, Lionis C, Chrousos GP, Manios Y, Healthy Growth Study Group. (2014) Dietary patterns and breakfast consumption in relation to insulin resistance in children. The Healthy Growth Study. Public Health Nutr. 17(12):2790-7. doi: 10.1017/S1368980013003327. Epub 2014 Jan 15.

760. Nicolaides NC, Roberts ML, Kino T, Braatvedt G, Hurt DE, Katsantoni E, Sertedaki A, Chrousos GP, Charmandari E. (2014) A Novel Point Mutation of the Human Glucocorticoid Receptor Gene Causes Primary Generalized Glucocorticoid Resistance through Impaired Interaction with the LXXLL Motif of the p160 Coactivators: Dissociation of the Transactivating and Transreppressive Activities. J Clin Endocrinol Metab. 99(5):E902-7. doi: 10.1210/jc.2013-3005. Epub 2014 Jan 31.

761. Bacopoulou F, Creatsas G, Chrousos GP, Papanikolaou N, Deligeoroglou E. (2014) Primary amenorrhea in adolescent girls: normal coitus or not? Always take a look in the physician's office. BMC Womens Health. 14(1):23. doi: 10.1186/1472-6874-14-23.

762. Al-Attas OS, Al-Daghri NM, Alokail MS, Alkharfy KM, Khan N, Alfawaz HA, Aiswaidan IA, Al-Ajlan AS, Chrousos GP. (2014) Association of dietary fatty acids intake with pro-coagulation and inflammation in Saudi Adults. Asia Pac J Clin Nutr. 23(1):55-64. doi: 10.6133/apjcn.2014.23.1.12.

763. Giannisi F, Pervanidou P, Michalaki E, Papanikolaou K, Chrousos G, Yannakoulia M. (2014) Parental readiness to implement life-style behaviour changes in relation to children's excess weight. J Paediatr Child Health. 50(6):476-81. doi: 10.1111/jpc.12500. Epub 2014 Feb 25.

764. Tsiouli E, Pavlopoulos V, Alexopoulos EC, Chrousos G, Darviri C. (2014) Short-term impact of a stress management and health promotion program on perceived stress, parental stress, health locus of control, and cortisol levels in parents of children and adolescents with diabetes type 1: a pilot randomized controlled trial. Explore (NY). 10(2):88-98. doi: 10.1016/j.explore.2013.12.004. Epub 2013 Dec 17.

765. Fernandez-Mendoza J, Vgontzas AN, Calhoun SL, Vgontzas A, Tsaoussoglou M, Gaines J, Liao D, Chrousos GP, Bixler EO. (2014) Insomnia Symptoms, Objective Sleep Duration, and Hypothalamic-Pituitary-Adrenal Activity in Children. Eur J Clin Invest. 44(5):493-500. doi: 10.1111/eci.12263.

766. Zavras N, Tsamoudaki S, Christianakis E, Schizas D, Pikoulis E, Kyritsi H, Chrousos G. (2014) Ring block with levobupivacaine 0.25% and paracetamol vs. paracetamol alone in children submitted to three different surgical techniques of circumcision: A prospective randomized study. Saudi J Anaesth. 8(1):45-50. doi: 10.4103/1658-354X.125936.

767. Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, Lohr JB, Geracioti TD jr., Patel PM, Chrousos GP, Baker D. (2014) Circadian Rhythmicity, Variability and Correlation of Interleukin-6 Levels in Plasma and Cerebrospinal Fluid in Healthy Men. Psychoneuroendocrinology. 44:71-82. doi: 10.1016/j.psyneuen.2014.02.020. Epub 2014 Mar 6.

768. Tragea C, Chrousos GP, Alexopoulos EC, Darviri C. (2014) A randomized controlled trial of the effects of a stress management programme during pregnancy. Complement Ther Med. 22(2):203-11. doi: 10.1016/j.ctim.2014.01.006. Epub 2014 Jan 30.

769. Gkourogianni A, Kosteria I, Telonis AG, Margeli A, Mantzou E, Konsta M, Loutradis D, Mastorakos G, Papassotiriou I, Klapa MI, Kanaka-Gantenbein C, Chrousos GP. (2014) Plasma Metabolomic Profiling 65

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Suggests Early Indications for Predisposition to Latent Insulin Resistance in Children Conceived by ICSI. PLoS One. 9(4):e94001. doi: 10.1371/journal.pone.0094001. eCollection 2014.

770. Al-Daghri NM, Al-Othman A, Albanyan A, Al-Attas OS, Alokail MS, Sabico S, Chrousos GP. (2014) Perceived Stress Scores among Saudi Students Entering Universities: A Prospective Study during the First Year of University Life. Int J Environ Res Public Health. 11(4):3972-81. doi: 10.3390/ijerph110403972.

771. Papaefthymiou MA, Bakoula C, Sarra A, Papassotiriou I, Chrousos GP, Bacopoulou F. (2014) Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study. J Pediatr Endocrinol Metab. 2014 Jul;27(7-8):685-92. doi: 10.1515/jpem-2013-0407.

772. Al-Daghri NM, Al-Othman A, Al-Attas OS, Alkharfy KM, Alokail MS, Albanyan A, Sabico S, Chrousos GP. (2014) Stress and cardiometabolic manifestations among Saudi students entering universities: a cross-sectional observational study. BMC Public Health. 14(1):391.

773. Ajabnoor GM, Bahijri S, Borai A, Abdulkhaliq AA, Al-Aama JY, Chrousos GP. (2014) Health Impact of Fasting in Saudi Arabia during Ramadan: Association with Disturbed Circadian Rhythm and Metabolic and Sleeping Patterns. PLoS One. 9(5):e96500.

774. Papanastasiou L, Markou A, Pappa T, Gouli A, Tsounas P, Fountoulakis S, Kounadi T, Tsiama V, Dasou A, Gryparis A, Samara C, Zografos G, Kaltsas G, Chrousos G, Piaditis G. (2014) Primary Aldosteronism in Hypertensive Patients: Clinical Implications and Target Therapy. Eur J Clin Invest. 44(8):697-706. doi: 10.1111/eci.12286.

775. Linardatou C, Parios A, Varvogli L, Chrousos G, Darviri C. (2014) An 8-week stress management program in pathological gamblers: A pilot randomized controlled trial. J Psychiatr Res. 56:137-43. doi: 10.1016/j.jpsychires.2014.05.013. Epub 2014 May 27.

776. Al-Daghri NM, Al-Attas OS, Johnston HE, Singhania A, Alokail MS, Alkharfy KM, Abd-Alrahman SH, Sabico SL, Roumeliotis TI, Manousopoulou-Garbis A, Townsend PA, Woelk CH, Chrousos GP, Garbis SD. (2014) Whole Serum 3D LC-nESI-FTMS Quantitative Proteomics Reveals Sexual Dimorphism in the Milieu Intérieur of Overweight and Obese Adults. J Proteome Res. 13(11):5094-105. doi: 10.1021/pr5003406. Epub 2014 Jul 29.

777. Chaidas K, Tsaoussoglou M, Theodorou E, Lianou L, Chrousos G, Kaditis AG. (2014) Poincaré plot width, morning urine norepinephrine levels, and autonomic imbalance in children with obstructive sleep apnea. Pediatr Neurol. 51(2):246-51. doi: 10.1016/j.pediatrneurol.2014.05.003. Epub 2014 May 9.

778. Pervanidou P, Chouliaras G, Akalestos A, Bastaki D, Apostolakou F, Papassotiriou I, Chrousos GP. (2014) Increased placental growth factor (PlGF) concentrations in children and adolescents with obesity and the metabolic syndrome. Hormones (Athens). 13(3):369-74. doi: 10.14310/horm.2002.1491.

779. Eleftheriades M, Papastefanou I, Lambrinoudaki I, Kappou D, Lavranos D, Akalestos A, Souka AP, Pervanidou P, Hassiakos D, Chrousos GP. (2014) Elevated placental growth factor concentrations at 11-14 weeks of gestation to predict gestational diabetes mellitus. Metabolism. 63(11):1419-25. doi: 10.1016/j.metabol.2014.07.016. Epub 2014 Aug 5.

780. Tsaoussoglou M, Hatzinikolaou S, Baltatzis GE, Lianou L, Maragozidis P, Balatsos NA, Chrousos G, Kaditis AG. (2014) Expression of Leukotriene Biosynthetic Enzymes in Tonsillar Tissue of Children With Obstructive Sleep Apnea: A Prospective Nonrandomized Study. JAMA Otolaryngol Head Neck Surg. 140(10):944-50. doi: 10.1001/jamaoto.2014.1936.

781. Darviri C, Alexopoulos EC, Artemiadis AK, Tigani X, Kraniotou C, Darvyri P, Chrousos GP. (2014) The Healthy Lifestyle and Personal Control Questionnaire (HLPCQ): a novel tool for assessing self-empowerment through a constellation of daily activities. BMC Public Health. 14:995. doi: 10.1186/1471-2458-14-995.

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782. Inskip H, Baird J, Barker M, Briley AL, D'Angelo S, Grote V, Koletzko B, Lawrence W, Manios Y, Moschonis G, Chrousos GP, Poston L, Godfrey K. (2014) Influences on adherence to diet and physical activity recommendations in women and children: insights from six European studies. Ann Nutr Metab.64(3-4):332-9. doi: 10.1159/000365042. Epub 2014 Oct 2.

783. Koloverou E, Tentolouris N, Bakoula C, Darviri C, Chrousos G. (2014) Implementation of a stress management program in outpatients with type 2 diabetes mellitus: a randomized controlled trial. Hormones (Athens). 13(4):509-18. doi: 10.14310/horm.2002.1492.

784. Dimou PA, Bacopoulou F, Darviri C, Chrousos GP. (2014) Stress management and sexual health of young adults: a pilot randomised controlled trial. Andrologia. 46(9):1022-31. doi: 10.1111/and.12190.

785. Darvyri P, Galanakis M, Avgoustidis AG, Vasdekis S, Artemiadis A, Tigani X, Chrousos GP, Darviri C. (2014) The Spiritual Well-Being Scale (SWBS) in Greek Population of Attica. Psychology. 5:1575-1582 doi: 10.4236/psych.2014.513168.

786. Sakka S, Siahanidou T, Voyatzis C, Pervanidou P, Kaminioti C, Lazopoulou N, Kanaka-Gantenbein C, Chrousos GP, Papassotiriou I. (2015) Elevated circulating levels of lipoprotein-associated phospholipase A2 in obese children. Clin Chem Lab Med. 53(7):1119-25. doi: 10.1515/cclm-2014-1081.

787. Al-Daghri NM, Aljohani NJ, Al-Attas OS, Al-Saleh Y, Wani K, Alnaami AM, Alfawaz H, Al-Ajlan AS, Kumar S, Chrousos GP, Alokail MS. (2015) Non-high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents. J Clin Lipidol. 9(1):35-41. doi: 10.1016/j.jacl.2014.11.001. Epub 2014 Nov 13.

788. Bacopoulou F, Petridou E, Korpa TN, Deligeoroglou E, Chrousos GP. (2015) External-cause mortality among adolescents and young adults in Greece over the millennium's first decade 2000-09. J Public Health (Oxf). 37(1):70-7. doi: 10.1093/pubmed/fdt115. Epub 2013 Dec 1.

789. Manios Y, Moschonis G, Papandreou C, Politidou E, Naoumi A, Peppas D, Mavrogianni C, Lionis C, Chrousos GP; on behalf of the „Healthy Growth Study‟ group. (2015) Revised Healthy Lifestyle-Diet Index and associations with obesity and iron deficiency in schoolchildren: The Healthy Growth Study.J Hum Nutr Diet. 28 Suppl 2:50-8. doi: 10.1111/jhn.12183. Epub 2013 Dec 5.

790. Livadas S, Dracopoulou M, Dastamani A, Sertedaki A, Maniati-Christidi M, Magiakou AM, Kanaka- Gantenbein C, Chrousos GP, Dacou-Voutetakis C. (2015) The spectrum of clinical, hormonal and molecular findings in 280 individuals with non-classical congenital adrenal hyperplasia caused by mutations of the CYP21A2 gene. Clin Endocrinol (Oxf). 82(4):543-9. doi: 10.1111/cen.12543. Epub 2014 Aug 3.

791. Voisin S, Almén MS, Moschonis G, Chrousos GP, Manios Y, Schiöth HB. (2015) Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents. Eur J Hum Genet. 23(5):654-62. doi: 10.1038/ejhg.2014.139. Epub 2014 Jul 30.

792. Stefanaki C, Bacopoulou F, Livadas S, Kandaraki A, Karachalios A, Chrousos GP, Diamanti-Kandarakis E. (2015) Impact of a Mindfulness Stress Management Program on Stress, Anxiety, Depression and Quality of Life in Women with Polycystic Ovary Syndrome: a Randomized Controlled Trial. Stress. 18(1):57-66. doi: 10.3109/10253890.2014.974030. Epub 2014 Dec 29.

793. Lazopoulou N, Gkioka E, Ntalla I, Pervanidou P, Magiakou AM, Roma-Giannikou E, Chrousos GP, Papassotiriou I, Dedoussis G, Kanaka-Gantenbein C. (2015) The combined effect of MC4R and FTO risk alleles on childhood obesity in Greece. Hormones (Athens). 14(1):126-33. doi: 10.14310/horm.2002.1524.

794. Papadopoulou-Marketou N, Skevaki C, Kosteria I, Peppa M, Chrousos GP, Papassotiriou I, Kanaka- Gantenbein C. (2015) NGAL and cystatin C: two possible early markers of diabetic nephropathy in young patients with type 1 diabetes mellitus: one year follow up. Hormones (Athens). 14(2):232-40. doi: 10.14310/horm.2002.1520. 67

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795. Tsigos C, Stefanaki C, Lambrou GI, Boschiero D, Chrousos GP. (2015) Stress And Inflammatory Biomarkers and Symptoms Are Associated With Bio-Impedance Measures. Eur J Clin Invest. 45(2):126-34. doi: 10.1111/eci.12388. Epub 2015 Jan 12.

796. Dassios T, Kaditis A, Katelari A, Chrousos G, Doudounakis S, Dimitriou G. (2015) Time constant of inspiratory muscle relaxation in cystic fibrosis. Pediatr Res. 77(4):541-5. doi: 10.1038/pr.2015.2. Epub 2015 Feb 2.

797. Panagiotopoulos G, Galanakis M, Varvogli L, Chrousos G, Darviri C. (2015) Validation of the Greek version of Mini Tinnitus Questionnaire as a Brief Screening Test for Assessment of Tinnitus related Distress: Our experience in three hundred and one adult patients. Clin Otolaryngol. 40(4):363-9. doi: 10.1111/coa.12383.

798. Al-Daghri NM, Aljohani NJ, Al-Attas OS, Al-Saleh Y, Wani K, Alnaami AM, Alfawaz H, Al-Ajlan AS, Kumar S, Chrousos GP, Alokail MS. (2015) Non-high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents. J Clin Lipidol. 9(1):35-41. doi: 10.1016/j.jacl.2014.11.001. Epub 2014 Nov 13.

799. Siahanidou T, Margeli A, Tsirogianni C, Hantzi E, Papassotiriou I, Chrousos G. (2015) Elevated circulating ghrelin, but not peptide YY(3-36) levels, in term neonates with infection. Clin Chem Lab Med. 53(11):1815- 24. doi: 10.1515/cclm-2014-1250.

800. Eriksson A, Williams MJ, Voisin S, Hansson I, Krishnan A, Philippot G, Yamskova O, Herisson FM, Dnyansagar R, Moschonis G, Manios Y, Chrousos GP, Olszewski PK, Frediksson R, Schiöth HB. (2015) Implication of coronin 7 in body weight regulation in humans, mice and flies. BMC Neurosci. 2015 Mar 14;16:13. doi: 10.1186/s12868-015-0151-9.

801. Al-Saleh Y, Al-Daghri NM, Khan N, Alfawaz H, Al-Othman AM, Alokail MS, Chrousos GP. (2015) Vitamin D status in Saudi school children based on knowledge. BMC Pediatr. 15(1):53. doi: 10.1186/s12887-015-0369- 9.

802. Paltoglou G, Fatouros IG, Valsamakis G, Schoina M, Avloniti A, Chatzinikolaou A, Kambas A, Draganidis D, Mantzou A, Papagianni M, Kanaka-Gantenbein C, Chrousos GP, Mastorakos G. (2015) Anti-oxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion. Pediatr Res. 78(2):158-64. doi: 10.1038/pr.2015.85. Epub 2015 May 4.

803. Bacopoulou F, Efthymiou V, Landis G, Rentoumis A, Chrousos GP. (2015) Waist circumference, waist-to-hip ratio and waist-to-height ratio reference percentiles for abdominal obesity among Greek adolescents. BMC Pediatr. 15(1): 50. doi: 10.1186/s12887-015-0366-z.

804. Markou A, Sertedaki A, Kaltsas G, Androulakis I, Marakaki C, Pappa T, Gouli A, Papanastasiou L, Fountoulakis S, Zacharoulis A, Karavidas A, Ragkou D, Charmandari E, Chrousos GP, Piaditis GP. (2015) Stress-induced aldosterone hypersecretion is a substancial subset of patients with essential hypertension. J Clin Endocrinol Metab. 100(8):2857-64. doi: 10.1210/jc.2015-1268. Epub 2015 May 14.

805. Settas N, Anapliotou M, Kanavakis E, Fryssira H, Sofocleous C, Dacou-Voutetakis C, Chrousos GP, Voutetakis A. (2015) A novel FOXL2 gene mutation and BMP15 variants in a woman with primary ovarian insufficiency and blepharophimosis-ptosis-epicanthus inversus syndrome. Menopause. 22(11):1264-8. doi: 10.1097/GME.0000000000000473.

806. Al-Daghri NM, Al-Attas OS, Krishnaswamy S, Mohammed AK, Alenad AM, Chrousos GP, Alokail MS. (2015) Association of Type 2 Diabetes Mellitus related SNP genotypes with altered serum adipokine levels and metabolic syndrome phenotypes. Int J Clin Exp Med. 8(3):4464-71. eCollection 2015.

807. Al-Daghri NM, Al-Saleh Y, Aljohani N, Alokail M, Al-Attas O, Alnaami AM, Sabico S, Alsulaimani M, Al- Harbi M, Alfawaz H, Chrousos GP. (2015) Vitamin D Deficiency and Cardiometabolic Risks: A Juxtaposition 68

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of Arab Adolescents and Adults. PLoS One. 10(7): e0131315. doi: 10.1371/journal.pone.0131315. eCollection 2015

808. Pervanidou P, Bastaki D, Chouliaras G, Papanikolaou K, Kanaka-Gantenbein C, Chrousos G. (2015) Internalizing and externalizing problems in obese children and adolescents: associations with daily salivary cortisol concentrations. Hormones (Athens). 14(4):623-31. doi: 10.14310/horm.2002.1602.

809. Geronikolou SA, Chamakou A, Mantzou A, Chrousos G, Kanaka-Gantenbein C. (2015) Frequent cellular phone use modifies hypothalamic-pituitary-adrenal axis response to a cellular phone call after mental stress in healthy children and adolescents: A pilot study. Sci Total Environ. 536:182-188. doi: 10.1016/j.scitotenv.2015.07.052.

810. Al-Daghri NM, Al-Attas OS, Wani K, Alnaami AM, Sabico S, Al-Ajlan A, Chrousos GP, Alokail MS. (2015) Sensitivity of various adiposity indices in identifying cardiometabolic diseases in Arab adults.Cardiovasc Diabetol. 14:101. doi: 10.1186/s12933-015-0265-5

811. Papastefanou I, Eleftheriades M, Kappou D, Lambrinoudaki I, Lavranos D, Pervanidou P, Sotiriadis A, Hassiakos D, Chrousos GP. (2015) Maternal serum osteocalcin at 11-14 weeks of gestation in gestational diabetes mellitus. Eur J Clin Invest. 45(10):1025-31. doi: 10.1111/eci.12500. Epub 2015 Aug 24.

812. Al-Daghri NM, Al-Attas OS, Krishnaswamy S, Yakout SM, Mohammed AK, Alenad AM, Chrousos GP, Alokail MS. (2015) Association between promoter region genetic variants of PTH SNPs and serum 25(OH)- vitamin D level. Int J Clin Exp Pathol. 8(7):8463-71. eCollection 2015.

813. Bacopoulou F, Karakitsos P, Kottaridi C, Stefanaki C, Deligeoroglou E, Theodoridou K, Chrousos GP, Michos A. (2016) Genital HPV in children and adolescents: does sexual activity make a difference? J Pediatr Adolesc Gynecol. 29(3):228-33. doi: 10.1016/j.jpag.2015.08.010. Epub 2015 Sep 3.

814. Lagousi T, Routsias JG, Piperi C, Tsakris AZ, Chrousos G, Theodoridou M, Spoulou V. (2015) Discovery of immunodominant B-cell epitopes within surface pneumococcal virulence proteins in paediatric patients with invasive pneumococcal disease. J Biol Chem. 290(46):27500-10. doi: 10.1074/jbc.M115.666818. Epub 2015 Sep 22.

815. Darviri C, Artemiadis AK, Protogerou A, Soldatos P, Kraniotou C, Darviri C, Artemiadis AK, Protogerou A, Soldatos P, Kranioutou C, Vasdekis S, Varvogli L, Nasothimiou E, Vasilopoulou E, Karantzi E, Linardatou A, Michou M, Chrousos GP. (2015) A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for prehypertensive and hypertensive patients: a quasi-experimental study in Greece. J Hum Hypertens. 2016 Jun;30(6):397-403. doi: 10.1038/jhh.2015.99. Epub 2015 Oct 1.

816. Bahijri SM, Ajabnoor GM, Borai A, Al-Aama JY, Chrousos GP. (2015) Effect of Ramadan fasting in Saudi Arabia on serum bone profile and immunoglobulins. Ther Adv Endocrinol Metab. 6(5):223-32. doi: 10.1177/2042018815594527

817. Nicolaides NC, Lamprokostopoulou A, Polyzos A, Kino T, Katsantoni E, Triantafyllou P, Christophoridis A, Katzos G, Dracopoulou M, Sertedaki A, Chrousos GP, Charmandari E. (2015) Transient Generalized Glucocorticoid Hypersensitivity. Eur J Clin Invest. 2015 Dec;45(12):1306-15. doi: 10.1111/eci.12554. Epub 2015 Nov 20.

818. Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. (2015) Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Sci Signal. 8(404):ra119. doi: 10.1126/scisignal.aac7695.

819. Hassiakos D, Eleftheriades M, Papastefanou I, Lambrinoudaki I, Kappou D, Lavranos D, Akalestos A, Aravantinos L, Pervanidou P, Chrousos G. (2016) Increased Maternal Serum Interleukin-6 Concentrations at 69

George P. Chrousos, M.D.

11 to 14 Weeks of Gestation in Low Risk Pregnancies Complicated with Gestational Diabetes Mellitus: Development of a Prediction Model. Horm Metab Res. 48(1):35-41. doi: 10.1055/s-0034-1395659. Epub 2015 Jan 7.

820. Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T. (2016) FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Mol Psychiatry. 21(2):277-89. doi: 10.1038/mp.2015.38. Epub 2015 Apr 7.

821. Thomopoulos TP, Skalkidou A, Dessypris N, Chrousos G, Karalexi MA, Karavasilis TG, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Sidi V, Stiakaki E, Moschovi M, Loutradis D, Petridou ET. (2016) Prelabor cesarean delivery and early-onset acute childhood leukemia risk. Eur J Cancer Prev. 25(2):155- 61. doi: 10.1097/CEJ.0000000000000151.

822. Pelekasis P, Zisi G, Koumarianou A, Marioli A, Chrousos G, Syrigos K, Darviri C. (2016) Forming a Stress Management and Health Promotion Program for Women Undergoing Chemotherapy for Breast Cancer: A Pilot Randomized Controlled Trial. Integr Cancer Ther. 15(2):165-74. doi: 10.1177/1534735415598225. Epub 2015 Aug 4.

823. Fotiou C, Vlastarakos PV, Bakoula C, Papagaroufalis K, Bakoyannis G, Darviri C, Chrousos G. (2016) Parental stress management using relaxation techniques in a neonatal intensive care unit: A randomised controlled trial. Intensive Crit Care Nurs. 32:20-8. doi: 10.1016/j.iccn.2015.08.006.

824. Kritikou I, Basta M, Vgontzas AN, Pejovic S, Fernandez-Mendoza J, Liao D, Bixler EO, Gaines J, Chrousos GP. (2016) Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure. Eur Respir J. 47(2):531-40. doi: 10.1183/13993003.00319-2015. Epub 2015 Nov 5.

825. Charmandari E, Zhang RG, Silveira LG, Fan QR, Chrousos GP, Sertedaki A, Latronico AC, Segaloff DL. (2016) Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation. Mol Endocrinol. 30(1):62-76. doi: 10.1210/me.2015-1205. Epub 2015 Nov 10.

826. Aravidou E, Eleftheriades M, Malamitsi-Puchner A, Anagnostopoulos AK, Aravantinos L, Dontas I, Aravidis C, Creatsas G, Tsangaris G, Chrousos GP. (2016) Protein expression in the brain of rat offspring in relation to prenatal caloric restriction. J Matern Fetal Neonatal Med. 29(16):2707-14. doi: 10.3109/14767058.2015.1102222. Epub 2015 Oct 30.

827. Sotiriadis A, Eleftheriades M, Chatzinikolaou F, Hassiakos D, Chrousos GP, Pervanidou P. (2016) National Curves of Fetal Growth in Singleton Fetuses of Greek Origin. Eur J Clin Invest. 46(5):425-33. doi: 10.1111/eci.12611. Epub 2016 Mar 22.

828. Syrengelas D, Kalampoki V, Kleisiouni P, Manta V, Mellos S, Pons R, Chrousos GP, Siahanidou T. (2016) Alberta Infant Motor Scale (AIMS) Performance of Greek Preterm Infants: Comparisons With Full-Term Infants of the Same Nationality and Impact of Prematurity-Related Morbidity Factors. Phys Ther. 96(7):1102- 8. doi: 10.2522/ptj.20140494. Epub 2015 Dec 4.

829. Kassi E, Semaniakou A, Sertedaki A, Evangelopoulos ME, Kazazoglou T, Kominakis A, Sfagos C, Charmandari E, Chrousos GP, Moutsatsou P. (2016) Sequencing analysis of the human glucocorticoid receptor (NR3C1) gene in multiple sclerosis patients. J Neurol Sci. 363:165-9. doi: 10.1016/j.jns.2016.02.054. Epub 2016 Feb 23.

830. Eleftheriades M, Vafaei H, Dontas I, Vaggos G, Marinou K, Pervanidou P, Sebire NJ, Chrousos GP, Nicolaides KH. (2016) Assessment of Body Composition in Wistar Rat Offspring by DXA in Relation to Prenatal and Postnatal Nutritional Manipulation. Pediatr Res. 80(2):319-25. doi: 10.1038/pr.2016.61. Epub 2016 Apr 8.

831. Tsiavos V, Markou A, Papanastasiou L, Kounadi T, Androulakis I, Voulgaris N, Zachaki A, Kassi E, Kaltsas 70

George P. Chrousos, M.D.

G, Chrousos G, Piaditis G. (2016) A New Highly Sensitive and Specific Overnight Combined Screening and Diagnostic Test for Primary Aldosteronism. Eur J Endocrinol. 175(1):21-8. doi: 10.1530/EJE-16-0003. Epub 2016 Apr 12.

832. Tsitsika AK, Andrie EK, Psaltopoulou T, Tzavara CK, Sergentanis TN, Ntanasis-Stathopoulos I, Bacopoulou F, Richardson C, Chrousos GP, Tsolia M. (2016) Association between problematic internet use, socio- demographic variables and obesity among European adolescents. Eur J Public Health. 26(4):617-22. doi: 10.1093/eurpub/ckw028. Epub 2016 Apr 25.

833. Karatzi K, Moschonis G, Polychronopoulou MC, Chrousos GP, Lionis C, Manios Y; Healthy Growth Study group. (2016) Cutoff points of waist circumference and trunk and visceral fat for identifying children with elevated inflammation markers and adipokines: The Healthy Growth Study. Nutrition. 32(10):1063-7. doi: 10.1016/j.nut.2016.02.022. Epub 2016 Mar 17.

834. Legakis I, Mantzouridis T, Bouboulis G, Chrousos GP. (2016) Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast. Arch Endocrinol Metab. 60(1):76-8. doi: 10.1590/2359-3997000000147.

835. Iliadis SI, Sylvén S, Hellgren C, Olivier JD, Schijven D, Comasco E, Chrousos GP, Sundström-Poromaa I, Skalkidou A. (2016) Mid-preganancy Corticotropin-releasing Hormone Levels in Association with Postpartum Depressive Symptoms. Depress Anxiety. 33(11):1023-1030. doi: 10.1002/da.22529. Epub 2016 May 27.

836. Metikaridis TD, Hadjipavlou A, Artemiadis A, Chrousos G, Darviri C. (2016) Effect of a stress management program on subjects with neck pain: A pilot randomized controlled trial. J Back Musculoskelet Rehabil. 2016 May 20. doi: 10.3233/BMR-160709. Online ahead of print.

837. Sertedaki A, Markou A, Vlachakis D, Kossida S, Campanac E, Hoffman DA, Sierra ML, Xekouki P, Stratakis CA, Kaltsas G, Piaditis GP, Chrousos GP, Charmandari E. (2016) Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without Primary Aldosteronism but with ACTH-dependent aldosterone hypersecretion. Clin Endocrinol (Oxf). 85(6):845-851. doi: 10.1111/cen.13132. Epub 2016 Jul 12.

838. Al-Daghri NM, Aljohani N, Rahman S, Sabico S, Al-Attas OS, Alokail MS, Al-Ajlan A, Chrousos GP. (2016) Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture. J Endocrinol Invest. 39(10):1125-30. doi: 10.1007/s40618-016-0496-7. Epub 2016 Jun 16.

839. Bachlava E, Loukopoulou S, Karanasios E, Chrousos G, Michos A. (2016) Management of coronary artery aneurysms using abciximab in children with Kawasaki disease. Int J Cardiol. 220:65-9. doi: 10.1016/j.ijcard.2016.06.062. Epub 2016 Jun 20.

840. Stefanaki C, Peppa M, Boschiero D, Chrousos GP. (2016) Healthy Overweight/Obese Youth: Early Osteosarcopenic Obesity Features. Eur J Clin Invest. 46(9):767-78. doi: 10.1111/eci.12659. Epub 2016 Aug 11.

841. Tholouli E, Maridaki-Kassotaki A, Varvogli L, Chrousos GP. (2016) Compassion as a mediator between stressful events and perceived stress in Greek students. Psychiatriki. Psychiatriki. 27(2):89-97. doi: 10.22365/jpsych.2016.272.89.

842. Kokka A, Mikelatou M, Fouka G, Varvogli L, Chrousos GP, Darviri C. (2016) Stress Management and Health Promotion in a Sample of Women With Intimate Partner Violence: A Randomized Controlled Trial. J Interpers Violence. 34(10):2034-2055. doi: 10.1177/0886260516658759. Epub 2016 Aug 15.

843. Al-Daghri NM, Sabico S, Al-Saleh Y, Al-Attas OS, Alnaami AM, Al-Rehaili MM, Al-Harbi M, Alfawaz H, Chrousos G, Alokail MS. (2016) Calculated adiposity and lipid indices in healthy Arab children as influenced by vitamin D status. J Clin Lipidol. 10(4):775-781. doi: 10.1016/j.jacl.2016.02.005. Epub 2016 Feb 20.

844. Stavrou S, Nicolaides NC, Papageorgiou I, Papadopoulou P, Terzioglou E, Chrousos GP, Darviri C, 71

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Charmandari E. (2016) The effectiveness of a stress-management intervention program in the management of overweight and obesity in childhood and adolescence. J Mol Biochem. 5(2):63-70. Epub 2016 Jul 31.

845. Tavoulari EF, Benetou V, Vlastarakos PV, Psaltopoulou T, Chrousos G, Kreatsas G, Gryparis A, Linos A. (2016) Factors affecting breastfeeding duration in Greece: What is important? World J Clin Pediatr. 5(3):349- 57. doi: 10.5409/wjcp.v5.i3.349. eCollection 2016 Aug 8. PMID:27610353

846. Al-Daghri NM, Alokail MS, Manousopoulou A, Heinson A, Al-Attas O, Al-Saleh Y, Sabico S, Yakout S, Woelk CH, Chrousos GP, Garbis SD. (2016) Sex specific vitamin D effects on blood coagulation among overweight adults. Eur J Clin Invest. 46(12):1031-1040. doi: 10.1111/eci.12688. Epub 2016 Nov 1.

847. Darviri C, Zavitsanou C, Delikou A, Giotaki A, Artemiadis A, Terentiou A, Chrousos GP. (2016) A Novel Non-Pharmaceutical Treatment for Patients with Mild Cognitive Impairment. Psychology. 7:678-686. doi:10.4236/psych.2016.75070

848. Darviri C, Zavitsanou C, Delikou A, Giotaki A, Artemiadis A, Anagnostouli M, Varvogli L, Vasdekis S, and Chrousos GP, (2016) Pythagorean Self-awareness Serves Successfully as a New Cognitive Behavioral-based Technique in Multiple Sclerosis Physical and Psychosocial Well-Being and Quality of Life. Psychology. 7: 572-583. doi: 10.4236/psych.2016.74059

849. Balasopoulou A, Stanković B, Panagiotara A, Nikčevic G, Peters BA, John A, Mendrinou E, Stratopoulos A, Legaki AI, Stathakopoulou V, Tsolia A, Govaris N, Govari S, Zagoriti Z, Poulas K, Kanariou M, Constantinidou N, Krini M, Spanou K, Radlovic N, Ali BR, Borg J, Drmanac R, Chrousos G, Pavlovic S, Roma E, Zukic B, Patrinos GP, Katsila T. (2016) Novel genetic risk variants for pediatric celiac disease. Hum Genomics. 10(1):34. doi: 10.1186/s40246-016-0091-1.

850. Bougea A, Kleisarchakis MK, Spantideas N, Voskou P, Thomaides T, Chrousos G, Belegri SA. (2016) Job stress and burnout in the care staff of Leros PIKPA Asylum 25 years after the first Deinstitutionalisation and Rehabilitation Greek Project. BJPsych Bull. 40(6):296-301. doi: 10.1192/pb.bp.115.052258.

851. Theodorakis MJ, Katsiki N, Arampatzi K, Chrousos GP. (2017) Modelling the oral glucose tolerance test in normal and impaired glucose tolerant states: A population approach. Curr Med Res Opin. 33(2):305-313. doi: 10.1080/03007995.2016.1254607. Epub 2016 Dec 31.

852. Bouzios I, Chouliaras G, Chrousos GP, Roma E, Gemou-Engesaeth V. (2017) Functional gastrointestinal disorders in Greek Children based on III criteria: identifying the child at risk. Neurogastroenterol Motil. 29(3). doi: 10.1111/nmo.12951. Epub 2016 Sep 28.

853. Moschonis G, Kaliora AC, Karatzi K, Michaletos A, Lambrinou CP, Karachaliou AK, Chrousos GP, Lionis C, Manios Y. (2017) Perinatal, sociodemographic and lifestyle correlates of increased total and visceral fat mass levels in schoolchildren in Greece: the Healthy Growth Study. Public Health Nutr. 20(4):660-670. doi: 10.1017/S1368980016002640. Epub 2016 Nov 8.

854. Paltoglou G, Schoina M, Valsamakis G, Salakos N, Avloniti A, Chatzinikolaou A, Margeli A, Skevaki C, Papagianni M, Kanaka-Gantenbein C, Papassotiriou I, Chrousos GP, Fatouros IG, Mastorakos G. (2017) Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys. Endocrine. 55(3):925-933. doi: 10.1007/s12020-017-1227-3. Epub 2017 Jan 16.

855. Karatzi K, Protogerou AD, Moschonis G, Tsirimiagou C, Androutsos O, Chrousos GP, Lionis C, Manios Y. (2017) Prevalence of hypertension and hypertension phenotypes by age and gender among schoolchildren in Greece: The Healthy Growth Study. Atherosclerosis. 259:128-133. doi: 10.1016/j.atherosclerosis.2017.01.027. Epub 2017 Jan 21.

856. Stavropoulos I, Pervanidou P, Gnardellis C, Loli N, Theodorou V, Mantzou A, Soukou F, Sinani O, Chrousos GP. (2017) Increased hair cortisol and antecedent somatic complaints in children with a first epileptic seizure. 72

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Epilepsy Behav. 68:146-152. doi: 10.1016/j.yebeh.2016.12.015. Epub 2017 Feb 9.

857. Korpa T, Pervanidou P, Angeli E, Apostolakou F, Papanikolaou K, Papassotiriou I, Chrousos GP, Kolaitis G. (2017) Mothers' parenting stress is associated with salivary cortisol profiles in children with Attention Deficit Hyperactivity Disorder. Stress. 20(2):149-158. doi: 10.1080/10253890.2017.1303472. Epub 2017 Mar 28.

858. Papafotiou C, Christaki E, van den Akker EL, Wester VL, Apostolakou F, Papassotiriou I, Chrousos GP, Pervanidou P. (2017) Hair cortisol concentrations exhibit a positive association with salivary cortisol profiles and are increased in obese prepubertal girls. Stress. 20(2):217-222. doi: 10.1080/10253890.2017.1303830. Epub 2017 Mar 23.

859. Ajabnoor GM, Bahijri S, Shaik NA, Borai A, Alamoudi AA, Al-Aama JY, Chrousos GP. (2017) Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors. PLoS One. 12(4):e0174342. doi: 10.1371/journal.pone.0174342. eCollection 2017.

860. Doulgeraki A, Petrocheilou A, Petrocheilou G, Chrousos G, Doudounakis SE, Kaditis AG. (2017) Body composition and lung function in children with cystic fibrosis and meconium ileus. Eur J Pediatr. 176(6):737- 743. doi: 10.1007/s00431-017-2906-z. Epub 2017 Apr 13.

861. Marakaki C, Karapanou O, Gryparis A, Hochberg Z, Chrousos G, Papadimitriou A. (2017) Early Adiposity Rebound and Premature Adrenarche. J Pediatr. 186:72-77. doi: 10.1016/j.jpeds.2017.03.058. Epub 2017 Apr 28.

862. Kyritsi EM, Koltsida G, Farakla I, Papanikolaou A, Critselis E, Mantzou E, Zoumakis E, Kolaitis G, Chrousos GP, Charmandari E. (2017) Psychological vulnerability to stress in carriers of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hormones (Athens). 16(1):42-53. doi: 10.14310/horm.2002.1718.

863. Papadopoulou-Marketou N, Margeli A, Papassotiriou I, Chrousos GP, Kanaka-Gantenbein C, Wahlberg J. (2017) NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus. J Diabetes Res. 2017:7526919. doi: 10.1155/2017/7526919. Epub 2017 May 15.

864. Valsamakis G, Papatheodorou DC, Chalarakis N, Vrachnis NN, Sidiropoulou EJ, Manolikaki M, Mantzou A, Margeli A, Papassotiriou I, Chrousos GP, Mastorakos G. (2017) In pregnancy increased maternal STAI trait stress score shows decreased insulin sensitivity and increased stress hormones. Psychoneuroendocrinology. 84:11-16. doi: 10.1016/j.psyneuen.2017.06.008. Epub 2017 Jun 13.

865. Peppa M, Stefanaki C, Papaefstathiou A, Boschiero D, Dimitriadis G, and Chrousos GP. (2017) Bioimpedance (BIA)-ACC®) vs. DEXA as a Screening Tool for Osteosarcopenia in Lean, Overweight and Obese Caucasian Postmenopausal Females. Hormones (Athens). 16(2):181-193. doi: 10.14310/horm.2002.1732.

866. Arditi JD, Thomaidis L, Frysira H, Doulgeraki A, Chrousos GP, Kanaka-Gantenbein C. (2017) Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years. J Pediatr Endocrinol Metab. 2017 Jul 26;30(7):797-803. doi: 10.1515/jpem-2016-0362.

867. Nicolaides NC, Kino T, Roberts ML, Katsantoni E, Sertedaki A, Moutsatsou P, Psarra AG, Chrousos GP, Charmandari E. (2017) The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions. J Mol Biochem.6(1):3-12. Epub 2017 Apr 15.

868. Kosteria I, Tsangaris GT, Gkourogianni A, Anagnostopoulos A, Papadopoulou A, Papassotiriou I, Loutradis D, Chrousos GP, Kanaka-Gantenbein C. (2017) Proteomics of Children Born After Intracytoplasmic Sperm Injection Reveal Indices of an Adverse Cardiometabolic Profile. J Endocr Soc. 1(4):288-301. doi: 10.1210/js.2016-1052. eCollection 2017 Apr 1.

869. Alexopoulos A, Dakoutrou M, Stefanaki K, Chrousos G, Kakourou T. (2017) Pediatric vasculitis: a single center experience. Int J Dermatol. 56(11):1130-1138. doi: 10.1111/ijd.13749. Epub 2017 Sep 19. 73

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870. Engert V, Kok BE, Papassotiriou I, Chrousos GP, Singer T. (2017) Specific reduction in cortisol stress reactivity after social but not attention-based mental training. Sci Adv. 3(10):e1700495. doi: 10.1126/sciadv.1700495. eCollection 2017 Oct.

871. Hadjipanayis A, Efstathiou E, Theophilou L, Chrousos G. (2017) Reversible brain lesion following growth hormone replacement therapy in an adolescent. BMJ Case Rep. 2017:bcr2017221885. doi: 10.1136/bcr-2017- 221885.

872. Kosteria I, Tsangaris GT, Gkourogianni A, Anagnostopoulos A, Papadopoulou A, Papassotiriou I, Loutradis D, Chrousos GP, Kanaka-Gantenbein C. (2017) Proteomics of Children Born after Intracytoplasmic Sperm Injection Reveal Indices of an Adverse Cardiometabolic Profile. J Endocr Soc. 1(4):288-301. doi: 10.1210/js.2016-1052. eCollection 2017 Apr 1.

873. Manios Y, Karatzi K, Protogerou AD, Moschonis G, Tsirimiagou C, Androutsos O, Lionis C, Chrousos GP. (2018) Prevalence of childhood hypertension and hypertension phenotypes by weight status and waist circumference: the Healthy Growth Study. Eur J Nutr. 57(3):1147-1155. doi: 10.1007/s00394-017-1398-y. Epub 2017 Mar 27.

874. Angelousi A, Nasiri-Ansari N, Spilioti E, Mantzou E, Kalotyxou V, Chrousos G, Kaltsas G, Kassi E. (2018) Altered expression of circadian clock genes in polyglandular autoimmune syndrome type III. Endocrine. 59(1):109-119. doi: 10.1007/s12020-017-1407-1. Epub 2017 Sep 7.

875. Alexopoulos A, Thanopoulou I, Dakoutrou M, Georgiadou E, Chrousos GP, Kakourou T. (2018) Atenolol treatment for severe Infantile Hemangiomas: a single-centre prospective study. J Eur Acad Dermatol Venereol. 32(3):e117-e119. doi: 10.1111/jdv.14590. Epub 2017 Nov 6.

876. Al-Daghri NM, Wani K, Sabico S, Garbis SD, Chrousos GP, Amer OE, Ansari MGA, Al-Saleh Y, Aljohani NJ, Al-Attas OS, Alokail MS. (2018) Sex-Specific Expression of Apolipoprotein Levels following Replenishment of Vitamin D. J Steroid Biochem Mol Biol. 180:129-136. doi: 10.1016/j.jsbmb.2017.12.005. Epub 2017 Dec 14.

877. Moschonis G, Karatzi K, Androutsos O, Lionis C, Chrousos GP, Manios Y. (2018) Anthropometric cut-off values identifying Greek children at risk of hypertension: the Healthy Growth Study. J Hum Hypertens. 32(3):190-196. doi: 10.1038/s41371-018-0031-8. Epub 2018 Feb 6.

878. Margoni D, Michalakakou K, Angeli E, Pervanidou P, Kanaka-Gantenbein C, Chrousos G, Papassotiriou I, Roma E. (2018) Serum brain-derived neurotrophic factor in children with coeliac disease. Eur J Clin Invest. 48(5):e12916. doi: 10.1111/eci.12916. Epub 2018 Mar 7.

879. Oikonomidi T, Vikelis M, Artemiadis A, Chrousos GP, Darviri C. (2018) Reliability and Validity of the Greek Migraine Disability Assessment (MIDAS) Questionnaire. Pharmacoecon Open. 2(1):77-85. doi: 10.1007/s41669-017-0034-3.

880. Angeli E, Korpa T, Johnson EO, Apostolakou F, Papassotiriou I, Chrousos GP, Pervanidou P. (2018) Salivary cortisol and alpha-amylase diurnal profiles and stress reactivity in children with Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology. 90:174-181. doi: 10.1016/j.psyneuen.2018.02.026. Epub 2018 Feb 23.

881. Moschonis G, Androutsos O, Hulshof T, Dracopoulou M, Chrousos GP, Manios Y. (2018) Vitamin D insufficiency is associated with insulin resistance independently of obesity in primary schoolchildren. The Healthy Growth Study. Pediatr Diabetes. 19(5):866-873. doi: 10.1111/pedi.12678. Epub 2018 Apr 22.

882. Tsoli S, Vasdekis S, Tigani X, Artemiadis A, Chrousos G, Darviri C. (2018) A novel cognitive behavioral treatment for patients with chronic insomnia: A pilot experimental study. Complement Ther Med. 37:61-63. doi: 10.1016/j.ctim.2018.01.015. Epub 2018 Feb 1.

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883. Manios Y, Karatzi K, Protogerou AD, Moschonis G, Tsirimiagkou C, Androutsos O, Lionis C, Chrousos GP,. (2018) Prevalence of childhood hypertension and hypertension phenotypes by weight status and waist circumference: The healthy growth study. Eur J Nutr. 57(3):1147-1155. doi: 10.1007/s00394-017-1398-y. Epub 2017 Mar 27.

884. Kolettis TM, Kontonika M, Lekkas P, Vlahos AP, Baltogiannis GG, Gatzoulis KA, Chrousos GP. (2018) Autonomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis. J Basic Clin Physiol Pharmacol. 29(4):339-345. doi: 10.1515/jbcpp-2017-0202.

885. Al-Daghri NM, Yakout SM, Wani K, Khattak MNK, Garbis SD, Chrousos GP, Al-Attas OS, Alokail MS. (2018) IGF and IGFBP as an index for discrimination between vitamin D supplementation responders and nonresponders in overweight Saudi subjects. Medicine (Baltimore). 97(19):e0702. doi: 10.1097/MD.0000000000010702.

886. Engert V, Kok BE, Puhlmann LM, Stalder T, Kirschbaum C, Apostolakou F, Papanastasopoulou C, Papassotiriou I, Pervanidou P, Chrousos GP, Singer T. (2018) Exploring the Multidimensional Complex Systems Structure of the Stress Response and its Relation to Health and Sleep Outcomes. Brain Behav Immun. 73:390-402. doi: 10.1016/j.bbi.2018.05.023. Epub 2018 Jun 6.

887. Stamatopoulos PG, Dangas G, Tsarouhas K, Ziogas G, Tsitsimpikou C, Stamatopoulos G, Chrousos G. (2018) Subtotal Occlusion of Left Anterior Coronary Artery in a Professional Athlete. Cardiology. 140(2):71-73. doi: 10.1159/000489601. Epub 2018 Jun 13.

888. Chouliaras G, Mantzou A, Margoni D, Tsilifis N, Pervanidou P, Panayotou I, Kanaka -Gantenbein C, Chrousos GP, Roma-Giannikou E. (2018) Body height in pediatric IBD: a structural equation model analysis. Eur J Clin Invest. 48(8):e12969. doi: 10.1111/eci.12969. Epub 2018 Jun 29.

889. Demakakos P, Chrousos GP, Biddulph JP. (2018) Childhood experiences of parenting and cancer risk at older ages: findings from the English Longitudinal Study of Ageing (ELSA). Int J Public Health. 63(7):823-832. doi: 10.1007/s00038-018-1117-3. Epub 2018 Jun 14.

890. Marakaki C, Pervanidou P, Papassotiriou I, Mastorakos G, Hochberg Z, Chrousos G, Papadimitriou A. (2018) Increased symptoms of anxiety and depression in prepubertal girls, but not boys, with premature adrenarche: associations with serum DHEAS and daily salivary cortisol concentrations. Stress. 21(6):564-568. doi: 10.1080/10253890.2018.1484446. Epub 2018 Jun 19.

891. Nikolakopoulou P, Chatzigeorgiou A, Kourtzelis I, Toutouna L, Masjkur J, Arps-Forker C, Poser SW, Rozman J, Rathkolb B, Aguilar-Pimentel JA; German Mouse Clinic Consortium, Wolf E, Klingenspor M, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Tsata V, Monasor LS, Troullinaki M, Witt A, Anastasiou V, Chrousos G, Yi CX, García-Cáceres C, Tschöp MH, Bornstein SR, Androutsellis-Theotokis A. (2018) Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain. Sci Rep. 8(1):11335. doi: 10.1038/s41598-018-29434-2.

892. Koutouzis EI, Daikos GL, Chatzichristou P, Michos AG, Koutouzi FI, Chrousos GP, Syriopoulou VP. (2018) Characteristics of Streptococcus pneumoniae serotype 19A isolates from children in the pre and post Conjugate Vaccine Era. Single center experience 1986-2015. Vaccine. 36(35):5245-5250. doi: 10.1016/j.vaccine.2018.07.055. Epub 2018 Jul 27.

893. Emmanouil CC, Pervanidou P, Charmandari E, Darviri C, Chrousos GP. (2018) The effectiveness of a health promotion and stress-management intervention program in a sample of obese children and adolescents. Hormones (Athens). 17(3):405-413. doi: 10.1007/s42000-018-0052-2. Epub 2018 Aug 11.

894. Karatzi K, Moschonis G, Botelli S, Androutsos O, Chrousos GP, Lionis C, Manios Y. (2018) Physical activity and sedentary behavior thresholds for identifying childhood hypertension and its phenotypes: The Healthy Growth Study. J Am Soc Hypertens. 12(10):714-722. doi: 10.1016/j.jash.2018.07.001. Epub 2018 Jul 10.

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895. Gorgogietas VA, Tsialtas I, Sotiriou N, Laschou VC, Karra AG, Leonidas DD, Chrousos GP, Protopapa E, Psarra AG. (2018) Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells. J Mol Biochem. 7(1):1-13.

896. Patro Golab B, Santos S, Voerman E, Lawlor DA, Jaddoe VWV, Gaillard R; MOCO Study Group Authors. (2018) Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. Lancet Child Adolesc Health. 2(11):812-821. doi: 10.1016/S2352-4642(18)30273-6. Epub 2018 Sep 7.

897. Al-Daghri NM, Manousopoulou A, Alokail MS, Yakout S, Alenad A, Garay-Baquero DJ, Fotopoulos M, Teng J, Al-Attas O, Al-Saleh Y, Sabico S, Chrousos GP, Garbis SD. (2018) Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study. Nutr Diabetes. 8(1):54. doi: 10.1038/s41387-018-0063-8.

898. Santos S, Eekhout I, Voerman E, Gaillard R, Barros H, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costet N, Crozier S, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Gagliardi L, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Huang RC, Inskip H, Jusko TA, Karvonen AM, Koletzko B, Küpers LK, Lagström H, Lawlor DA, Lehmann I, Lopez-Espinosa MJ, Magnus P, Majewska R, Mäkelä J, Manios Y, McDonald SW, Mommers M, Morgen CS, Moschonis G, Murínová Ľ, Newnham J, Nohr EA, Andersen AN, Oken E, Oostvogels AJJM, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Santa-Marina L, Santos AC, Smit HA, Sørensen TIA, Standl M, Stanislawski M, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, van Gelder MMHJ, van Rossem L, von Berg A, Vrijheid M, Vrijkotte TGM, Zvinchuk O, van Buuren S, Jaddoe VWV. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania.BMC Med. 16(1):201. doi: 10.1186/s12916-018-1189-1.

899. Katsarou MS, Karathanasopoulou A, Andrianopoulou A, Desiniotis V, Tzinis E, Dimitrakis E, Lagiou M, Charmandari E, Aschner M, Tsatsakis AM, Chrousos GP, Drakoulis N. (2018) Beta 1, Beta 2 and Beta 3 Adrenergic Receptor Gene Polymorphisms in a Southeastern European Population. Front Genet. 9:560. doi: 10.3389/fgene.2018.00560. eCollection 2018.

900. Xenaki N, Bacopoulou F, Kokkinos A, Nicolaides NC, Chrousos GP, Darviri C. (2018) Impact of a stress management program on weight loss, mental health and lifestyle in adults with obesity: a randomized controlled trial. J Mol Biochem. 7(2):78-84. Epub 2018 Oct 3.

901. Manios Y, Karatzi K, Moschonis G, Ioannou G, Androutsos O, Lionis C, Chrousos G. (2019) Lifestyle, anthropometric, socio-demographic and perinatal correlates of early adolescence hypertension: The Healthy Growth Study. Nutr Metab Cardiovasc Dis. 29(2):159-169. doi: 10.1016/j.numecd.2018.10.007. Epub 2018 Oct 25.

902. Al-Daghri NM, Sabico S, Al-Hazmi H, Alenad AM, Al-Amro A, Al-Ghamdi A, Hussain SD, Chrousos G, Alokail MS. (2019) Circulating spexin levels are influenced by the presence or absence of gestational diabetes. Cytokine. 113:291-295. doi: 10.1016/j.cyto.2018.07.023. Epub 2018 Jul 19.

903. Child CJ, Zimmermann AG, Chrousos GP, Cummings E, Deal CL, Hasegawa T, Jia N, Lawrence S, Linglart A, Loche S, Maghnie M, Pérez Sánchez J, Polak M, Predieri B, Richter-Unruh A, Rosenfeld RG, Yeste D, Yorifuji T, Blum WF. (2019) Safety outcomes during pediatric GH therapy: final results from the prospective GeNeSIS observational program. J Clin Endocrinol Metab. 104(2):379-389. doi: 10.1210/jc.2018-01189.

904. Chatzikonstantinou F, Miskedaki A, Antoniou C, Chatzikonstantinou M, Chrousos G, Darviri C. (2019) A novel cognitive stress management technique for acne vulgaris: a short report of a pilot experimental study. Int J Dermatol. 58(2):218-220. doi: 10.1111/ijd.14227. Epub 2018 Sep 19.

905. Farakla I, Koui E, Arditi J, Papageorgiou I, Bartzeliotou A, Papadopoulos GE, Mantzou A, Papathanasiou C, Dracopoulou M, Papastamataki M, Moutsatsou P, Papassotiriou I, Chrousos GP, Charmandari E. (2019) Effect 76

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of Honey on Glucose and Insulin Concentrations in Obese Girls. Eur J Clin Invest. 49(2):e13042. doi: 10.1111/eci.13042. Epub 2018 Nov 16.

906. Agorastos A, Hauger RL, Barkauskas DA, Lerman IR, Moeller-Bertram T, Snijders C, Haji U, Patel PM, Geracioti TD, Chrousos GP, Baker DG. (2019) Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity. Psychoneuroendocrinology. 100:237-245. doi: 10.1016/j.psyneuen.2018.09.009. Epub 2018 Sep 10.

907. Anagnostouli M, Babili I, Chrousos G, Artemiadis A, Darviri C. Anagnostouli M, Babili I, Chrousos G, Artemiadis A, Darviri C. (2019) A novel cognitive-behavioral stress management method for multiple sclerosis. A brief report of an observational study. Neurol Res. 41(3):223-226. doi: 10.1080/01616412.2018.1548745. Epub 2018 Nov 19.

908. Polytarchou A, Katsouli G, Tsaoussoglou M, Charmandari E, Kanaka-Gantenbein C, Chrousos G, Kaditis AG. (2019) Obstructive events in children with Prader-Willi syndrome occur predominantly during rapid eye movement sleep. Sleep Med. 54:43-47. doi: 10.1016/j.sleep.2018.09.026. Epub 2018 Oct 28.

909. Chouliaras G, Kondyli C, Bouzios I, Spyropoulos N, Chrousos GP, Roma-Giannikou E. (2019) Dietary Habits and Abdominal Pain-related Functional Gastrointestinal Disorders: A School-based, Cross-sectional Analysis in Greek Children and Adolescents. J Neurogastroenterol Motil. 25(1):113-122. doi: 10.5056/jnm17113.

910. Katsouli G, Polytarchou A, Tsaoussoglou M, Loukou I, Chrousos G, Kaditis AG. (2019) Nocturnal oximetry in children with obstructive lung disease or sleep-disordered breathing. Pediatr Pulmonol. 54(5):551-556. doi: 10.1002/ppul.24259. Epub 2019 Jan 22.

911. Voerman E, Santos S, Patro Golab B, Amiano P, Ballester F, Barros H, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costet N, Crozier S, Devereux G, Eggesbø M, Ekström S, Fantini MP, Farchi S, Forastiere F, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hryhorczuk D, Huang RC, Inskip H, Iszatt N, Karvonen AM, Kenny LC, Koletzko B, Küpers LK, Lagström H, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, McAuliffe FM, McDonald SW, Mehegan J, Mommers M, Morgen CS, Mori TA, Moschonis G, Murray D, Chaoimh CN, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Ronfani L, Santos AC, Standl M, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Rossem L, von Berg A, Vrijheid M, Vrijkotte TGM, West J, Wijga A, Wright J, Zvinchuk O, Sørensen TIA, Lawlor DA, Gaillard R, Jaddoe VWV. (2019) Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis. PLoS Med. 16(2):e1002744. doi: 10.1371/journal.pmed.1002744. eCollection 2019 Feb.

912. Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costa O, Costet N, Crozier S, Devereux G, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Huang RC, Inskip H, Karvonen AM, Kenny LC, Koletzko B, Küpers LK, Lagström H, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, McAuliffe FM, McDonald SW, Mehegan J, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Chaoimh CN, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Gelder MMHJ, van Rossem L, von Berg A, Vrijheid M, Vrijkotte TGM, West J, Wijga AH, Wright J, Zvinchuk O, Sørensen TIA, Lawlor DA, Gaillard R, Jaddoe VWV. (2019) Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts. BJOG. 126(8):984-995. doi: 10.1111/1471-0528.15661. Epub 2019 Mar 20.

913. Galanou S, Chouliaras G, Girginoudis P, Mengreli C, Sertedaki A, Dracopoulou M, Farakla I, Platis D, Iliadi A, Chrousos GP, Dacou-Voutetakis C, Zoumakis E, Magiakou AM, Kanaka-Gantenbein C, Voutetakis A. (2019) Adrenal steroids in female hypothyroid neonates: Unraveling an association between thyroid hormones & adrenal remodeling. J Clin Endocrinol Metab. jc.2018-02013. doi: 10.1210/jc.2018-02013. Online ahead of 77

George P. Chrousos, M.D.

print.

914. Magriplis E, Dimakopoulos I, Karageorgou D, Mitsopoulou AV, Bakogianni I, Micha R, Michas G, Ntouroupi T, Tsaniklidou SM, Argyri K, Danezis G, Georgiou C, Panagiotakos DB, Zampelas A; HNNHS Contributors; HNNHS Advisory Committee. (2019) Aims, design and preliminary findings of the Hellenic National Nutrition and Health Survey (HNNHS). BMC Med Res Methodol. 19(1):37. doi: 10.1186/s12874-018-0655-y.

915. Demakakos P, Pashayan N, Chrousos G, Linara-Demakakou E, Mishra GD. (2019) Childhood experiences of parenting and age at menarche, age at menopause and duration of reproductive lifespan: Evidence from the English Longitudinal Study of Ageing. Maturitas. 122:66-72. doi: 10.1016/j.maturitas.2019.01.010. Epub 2019 Jan 23.

916. Chrousos GP, Boschiero D. (2019) Clinical validation of a non-invasive electrodermal biofeedback device useful for reducing chronic perceived pain and systemic inflammation. Hormones (Athens). 18(2):207-213. doi: 10.1007/s42000-019-00098-5. Epub 2019 Feb 25.

917. Tsartsalis AN, Lambrou GI, Tsartsalis DN, Papassotiriou I, Vlachou E, Terpos E, Chrousos GP, Kanaka- Gantenbein C, Kattamis A. (2019) Bone Metabolism Markers in Thalassemia Major-Induced Osteoporosis: Results from a Cross-Sectional Observational Study. Curr Mol Med. 19(5):335-341. doi: 10.2174/1566524019666190314114447.

918. Linz R, Puhlmann LMC, Apostolakou F, Mantzou E, Papassotiriou I, Chrousos GP, Engert V, Singer T. (2019) Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training. Neuropsychopharmacology. 44(10):1797-1804. doi: 10.1038/s41386-019- 0391-y. Epub 2019 Apr 16.

919. Manousopoulou A, Al-Daghri NM, Sabico S, Garay-Baquero DJ, Teng J, Alenad A, Alokail MS, Athanasopoulos N, Deligeoroglou E, Chrousos GP, Bacopoulou F, Garbis SD. (2019) Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in adolescent, Normal-Weight Females. Proteomics Clin Appl. 13(5):e1800184. doi: 10.1002/prca.201800184. Epub 2019 Apr 23.

920. Moschonis G, Michalopoulou M, Tsoutsoulopoulou K, Vlachopapadopoulou E, Michalacos S, Charmandari E, Chrousos GP, Manios Y. (2019) Assessment of the Effectiveness of a Computerised Decision-Support Tool for Health Professionals for the Prevention and Treatment of Childhood Obesity. Results from a Randomised Controlled Trial. Nutrients. 11(3):706. doi: 10.3390/nu11030706.

921. LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, Voerman E, Santos S, Inskip H, Amiano P, Barros H, Charles MA, Chatzi L, Chrousos GP, Corpeleijn E, Crozier S, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Gori D, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Iñiguez C, Karvonen AM, Küpers LK, Lagström H, Lawlor DA, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, Mommers M, Morgen CS, Moschonis G, Nohr EA, Nybo Andersen AM, Oken E, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Trnovec T, van Gelder MMHJ, van Rossem L, von Berg A, Vrijheid M, Wijga A, Zvinchuk O, Sørensen TIA, Godfrey K, Jaddoe VWV, Gaillard R. (2019) Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes. JAMA. 321(17):1702-1715. doi: 10.1001/jama.2019.3820.

922. Straube R, Voit-Bak K, Gor A, Steinmeier T, Chrousos GP, Boehm BO, Birkenfeld AL, Barbir M, Balanzew W, Bornstein SR. (2019) Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis? Horm Metab Res. 51(5):326-329. doi: 10.1055/a-0885-7169. Epub 2019 May 9.

923. Vlachopoulos C, Kosteria I, Sakka S, Gkourogianni A, Terentes-Printzios D, Koutagiar I, Skoumas I, Miliou A, Papassotiriou I, Gardikioti V, Loutradis D, Chrousos G, Kanaka-Gantenbein C, Tousoulis D. (2019) PCSK9 and Lp(a) levels of children born after assisted reproduction technologies. J Assist Reprod Genet. 36(6):1091- 1099. doi: 10.1007/s10815-019-01474-1. Epub 2019 May 11. 78

George P. Chrousos, M.D.

924. Nicolaides NC, Polyzos A, Koniari E, Lamprokostopoulou A, Papageorgiou I, Golfinopoulou E, Papathanasiou C, Sertedaki A, Thanos D, Chrousos GP, Charmandari E. (2019) Transcriptomics in Tissue Glucocorticoid Sensitivity.Eur J Clin Invest. 49(8):e13129. doi: 10.1111/eci.13129. Epub 2019 May 30.

925. Legakis I MD, Adamopoulos D, Stamatiou I, Gryparis A, Chrousos GP. (2019) Divergent patterns of thyroid- stimulating hormone and other thyroidal parameter levels in relationship with the sex of healthy neonates and infants less than two years old: a longitudinal study. Thyroid. 29(7):920-927. doi: 10.1089/thy.2018.0134.

926. Karageorgou D, Magriplis E, Mitsopoulou AV, Dimakopoulos I, Bakogianni I, Micha R, Michas G, Chourdakis M, Ntouroupi T, Tsaniklidou SM, Argyri K, Panagiotakos DB, Zampelas A; HNNHS Contributors; HNNHS Advisory Committee. (2019) Dietary patterns and lifestyle characteristics in adults: results from the Hellenic National Nutrition and Health Survey (HNNHS). Public Health. 171:76-88. doi: 10.1016/j.puhe.2019.03.013. Epub 2019 May 18.

927. Magriplis E, Mitsopoulou AV, Karageorgou D, Bakogianni I, Dimakopoulos I, Micha R, Michas G, Chourdakis M, Chrousos GP, Roma E, Panagiotakos D, Zampelas A. (2019) Frequency and Quantity of Egg Intake Is Not Associated with Dyslipidemia: The Hellenic National Nutrition and Health Survey (HNNHS). Nutrients. 11(5):1105. doi: 10.3390/nu11051105.

928. Poser SW, Otto O, Arps-Forker C, Ge Y, Herbig M, Andree C, Gruetzmann K, Adasme MF, Stodolak S, Nikolakopoulou P, Park DM, Mcintyre A, Lesche M, Dahl A, Lennig P, Bornstein SR, Schroeck E, Klink B, Leker RR, Bickle M, Chrousos GP, Schroeder M, Cannistraci CV, Guck J, Androutsellis-Theotokis A. (2019) Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery. FASEB J. 33(8):9235-9249. doi: 10.1096/fj.201802603RR. Epub 2019 May 30.

929. Makris G, Chrousos GP, Anesiadou S, Sabico S, Abd-Alrahman SH, Al-Daghri NM, Chouliaras G, Pervanidou P. (2019) Serum concentrations and detection rates of selected organochlorine pesticides in a sample of Greek school-aged children with neurodevelopmental disorders. Environ Sci Pollut Res Int. 26(23):23739-23753. doi: 10.1007/s11356-019-05666-1. Epub 2019 Jun 17.

930. Magriplis E, Panagiotakos D, Mitsopoulou AV, Karageorgou D, Bakogianni I, Dimakopoulos I, Micha R, Michas G, Chourdakis M, Chrousos GP, Roma E, Zampelas A. (2019) Prevalence of hyperlipidaemia in adults and its relation to the Mediterranean diet: the Hellenic National Nutrition and Health Examination Survey (HNNHS). Eur J Prev Cardiol. 26(18):1957-1967. doi: 10.1177/2047487319866023. Epub 2019 Jul 26.

931. Hoare E, Marx W, Firth J, McLeod S, Jacka F, Chrousos GP, Manios Y, Moschonis G. (2019) Lifestyle behavioural risk factors and emotional functioning among schoolchildren: The Healthy Growth Study. Eur Psychiatry. 61:79-84. doi: 10.1016/j.eurpsy.2019.07.002. Epub 2019 Aug 1.

932. Paltoglou G, Avloniti A, Chatzinikolaou A, Stefanaki C, Papagianni M, Papassotiriou I, Fatouros IG, Chrousos GP, Kanaka-Gantenbein C, Mastorakos G. (2019) In early pubertal boys, testosterone and LH are associated with improved anti-oxidation during an aerobic exercise bout. Endocrine. 66(2):370-380. doi: 10.1007/s12020- 019-02037-1. Epub 2019 Aug 4.

933. Markomanolaki ZS, Tigani X, Siamatras T, Bacopoulou F, Tsartsalis A, Artemiadis A, Megalooikonomou V, Vlachakis D, Chrousos GP, Darviri C. (2019) Stress Management in Women with Hashimoto's thyroiditis: A Randomized Controlled Trial. J Mol Biochem. 8(1):3-12.

934. Kalogiratou DS, Bacopoulou F, Kanaka-Gantenbein C, Vlachakis D, Gerakini O, Chrousos GP, Darviri C. (2019) Greek Validation of Emotional Eating Scale for Children and Adolescents. J Mol Biochem. J Mol Biochem. 8(1):26-32.

935. Simos DS, Kokkinos A, Tentolouris N, Dimosthenopoulos C, Mantzou E, Artemiadis A, Bacopoulou F, Nicolaides NC, Kosta O, Chrousos GP, Darviri C. (2019) Pythagorean Self-Awareness Intervention (PSAI): a Novel Cognitive Stress Management Technique for Body Weight Control. Eur J Clin Invest. 49(10):e13164. 79

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doi: 10.1111/eci.13164. Epub 2019 Sep 16.

936. Siahanidou T, Dessypris N, Analitis A, Mihas C, Evangelou E, Chrousos G, Petridou E. (2019) Disparities of infant and neonatal mortality trends in Greece during the years of economic crisis by ethnicity, place of residence and human development index: a nationwide population study. BMJ Open. 9(8):e025287. doi: 10.1136/bmjopen-2018-025287.

937. Henriksson HE, Malavaki C, Bränn E, Drainas V, Lager S, Iliadis SI, Papadopoulos FC, Sundström Poromaa I, Chrousos GP, Klapa MI, Skalkidou A. (2019) Blood plasma metabolic profiling of pregnant women with antenatal depressive symptoms. Transl Psychiatry. 9(1):204. doi: 10.1038/s41398-019-0546-y.

938. Tsoli S, Galanakis M, Koumarianou A, Makris G, Kapogiannis A, Chrousos G. (2019) Validation of the Patient Empowerment Strategies Questionnaire (PES-Q) in Greek adult patients with chronic insomnia: a pilot study on basic psychometric values. Prim Health Care Res Dev. 20:e130. doi: 10.1017/S1463423619000616.

939. Kosteria I, Aloumanis K, Kanaka-Gantenbein C, Vlachopapadopoulou E, Michalacos S, Stamoyannou L, Drossinos E, Chrousos G; Hellenic GeNeSIS study group. (2019) Pediatric growth hormone therapy in Greece: analysis of the Hellenic cohort of the GeNeSIS study. Hormones (Athens). 18(4):423-434. doi: 10.1007/s42000-019-00148-y. Epub 2019 Nov 6.

940. Pervanidou P, Makris G, Bouzios I, Chrousos G, Roma E, Chouliaras G. (2019) Bullying victimization: Associated contextual factors in a Greek sample of children and adolescents. Psychiatriki. 30(3):216-225. doi: 10.22365/jpsych.2019.303.216.

941. Magriplis E, Panagiotakos D, Tsioufis C, Mitsopoulou AV, Karageorgou D, Dimakopoulos I, Bakogianni I, Chourdakis M, Micha R, Michas G, Ntouroupi T, Tsaniklidou SM, Argyri K, Zampelas A; Contributors; Advisory Committee. (2019) Hypertension prevalence in a representative sample of Greek adults: The Hellenic National Nutrition and Health Survey (HNNHS). Hellenic J Cardiol. S1109-9666(19)30290-8. doi: 10.1016/j.hjc.2019.10.013. Online ahead of print.

942. Puhlmann LMC, Engert V, Apostolakou F, Papassotiriou I, Chrousos GP, Vrtička P, Singer T. (2019) Only vulnerable adults show change in chronic low-grade inflammation after contemplative mental training: evidence from a randomized clinical trial. Sci Rep. 9(1):19323. doi: 10.1038/s41598-019-55250-3.

943. Ntaouti E, Gonidakis F, Nikaina E, Varelas D, Creatsas G, Chrousos G, Siahanidou T. (2020) Maternity Blues: risk factors in Greek population and validity of the Greek version of Kennerley and Gath's Blues Questionnaire. J Matern Fetal Neonatal Med. 33(13):2253-2262. doi: 10.1080/14767058.2018.1548594. Epub 2018 Nov 28.

944. Tatsi EB, Kanaka-Gantenbein C, Scorilas A, Chrousos GP, Sertedaki A. (2020) Next Generation Sequencing Targeted Gene Panel in Greek MODY patients increases diagnostic accuracy. Pediatr Diabetes. 21(1):28-39. doi: 10.1111/pedi.12931. Epub 2019 Nov 10.

945. Karageorgou D, Magriplis E, Bakogianni I, Mitsopoulou AV, Dimakopoulos I, Micha R, Michas G, Ntouroupi T, Tsaniklidou SM, Argyri K, Chourdakis M, Panagiotakos DB, Zampelas A; HNNHS Contributors; HNNHS Advisory Committee. (2020) Dietary patterns and cardiovascular disease in Greek adults: The Hellenic National Nutrition and Health Survey (HNNHS). Nutr Metab Cardiovasc Dis. 30(2):201-213. doi: 10.1016/j.numecd.2019.09.024. Epub 2019 Sep 30.

946. Mavrogeni S, Giannakopoulou A, Katsalouli M, Pons RM, Papavasiliou A, Kolovou G, Noutsias M, Papadopoulos G, Karanasios E, Chrousos GP. (2020) Friedreich's Ataxia: Case series and the Additive Value of Cardiovascular Magnetic Resonance. J Neuromuscul Dis. 7(1):61-67. doi: 10.3233/JND-180373.

947. Fountoulakis S, Papanastasiou L, Voulgaris N, Kounadi T, Markou A, Chrousos GP, Piaditis G. (2020) Salt intake in mineralocorticoid receptor antagonist-treated primary aldosteronism: foe or ally? Hormones (Athens). 19(2):223-232. doi: 10.1007/s42000-019-00167-9. Epub 2019 Dec 21. 80

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948. Ferle V, Repouskou A, Aspiotis G, Raftogianni A, Chrousos G, Stylianopoulou F, Stamatakis A. (2020) Synergistic effects of early life mild adversity and chronic social defeat on rat brain microglia and cytokines. Physiol Behav. 215:112791. doi: 10.1016/j.physbeh.2019.112791. Epub 2019 Dec 21.

949. Charalampopoulou M, Bacopoulou F, Syrigos KN, Filopoulos E, Chrousos GP, Darviri C. (2020) The effects of Pythagorean Self-Awareness Intervention on breast cancer patients undergoing adjuvant therapy: A pilot randomized controlled trial. Breast. 49:210-218. doi: 10.1016/j.breast.2019.12.012. Epub 2019 Dec 20.

950. Dimakopoulos I, Magriplis E, Mitsopoulou AV, Karageorgou D, Bakogianni I, Micha R, Michas G, Chourdakis M, Chrousos GP, Roma E, Panagiotakos DB, Zampelas A. (2020) Intake and contribution of food groups to vitamin D intake in a representative sample of adult Greek population. Nutrition. 72:110641. doi: 10.1016/j.nut.2019.110641. Epub 2019 Nov 15.

951. Kapsali F, Zioga I, Papageorgiou P, Smyrnis N, Chrousos GP, Papageorgiou C. (2020) Event-related EEG oscillations in Body Dysmorphic Disorder. Eur J Clin Invest. 2020 Mar;50(3): e13208. doi: 10.1111/eci.13208. Epub 2020 Feb 12.

952. Wani K, Alfawaz H, Alnaami AM, Sabico S, Khattak MNK, Al-Attas O, Alokail MS, Alharbi M, Chrousos G, Kumar S, Al-Daghri NM. (2020) Effects of A 12-Month Intensive Lifestyle Monitoring Program in Predominantly Overweight/Obese Arab Adults with Prediabetes. Nutrients. 12(2):464. doi: 10.3390/nu12020464.

953. Siahanidou T, Karalexi MA, Kantzanou M, Dessypris N, Christodoulakis C, Daoutakos P, Aggelou K, Loutradis D, Chrousos GP, Petridou ET. (2020) Stillbirth in Greece during the years of economic crisis: a population-based study. Eur J Pediatr. 179(7):1157-1166. doi: 10.1007/s00431-020-03588-6. Epub 2020 Feb 15.

954. Herhaus B, Ullmann E, Chrousos G, Petrowski K. (2020) High/low cortisol reactivity and food intake in people with obesity and healthy weight. Transl Psychiatry. 10(1):40. doi: 10.1038/s41398-020-0729-6.

955. Livadas S, Bothou C, Kanaka-Gantenbein C, Chiotis D, Angelopoulos N, Macut D, Chrousos GP. (2020) Unfavorable Hormonal and Psychologic Profile in Adult Women with a History of Premature Adrenarche and Pubarche, Compared to Women with Polycystic Ovary Syndrome. Horm Metab Res. 52(3):179-185. doi: 10.1055/a-1109-2630. Epub 2020 Feb 19.

956. Gontika M, Skarlis C, Artemiadis A, Pons R, Mastroyianni S, Vartzelis G, Theodorou V, Kilindireas K, Stefanis L, Dalakas M, Chrousos G, Anagnostouli M. (2020) HLA-DRB1 allele impact on pediatric multiple sclerosis in a Hellenic cohort. Mult Scler J Exp Transl Clin. 6(1):2055217320908046. doi: 10.1177/2055217320908046. eCollection Jan-Mar 2020.

957. Giannakopoulos G, Margoni D, Chouliaras G, Panayiotou J, Zellos A, Papadopoulou A, Liakopoulou M, Chrousos G, Kanaka-Gantenbein C, Kolaitis G, Roma E. (2020) Child and Parent Mental Health Problems in Pediatric Celiac Disease: A Prospective Study. J Pediatr Gastroenterol Nutr. doi: 10.1097/MPG.0000000000002769. Online ahead of print.

958. Papageorgiou CC, Kouroupetroglou GTH, Stachtea XP, Papageorgiou PC, Mavromatos AK, Chrousos GP, Logothetis NK, Tsaltas E. (2020) Perspective-Taking in Blindness: An Event-related Brain Potentials Study with the Continuous Wavelet Transformation. IEEE Access, vol. 8, pp. 76657-76670, 2020, doi: 10.1109/ACCESS.2020.2990095.

959. Ortiz R, Gemmill JAL, Sinaii N, Stegmann B, Khachikyan I, Chrousos G, Segars J, Stratton P. (2020) Hypothalamic-Pituitary-Adrenal Axis Responses in Women with Endometriosis-Related Chronic Pelvic Pain. Reprod Sci. doi: 10.1007/s43032-020-00201-x. Online ahead of print. PMID: 32572832.

960. Louvardi M, Pelekasis P, Chrousos GP, Darviri C. (2020) Mental Health in Chronic Disease Patients during the 81

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COVID-19 Quarantine in Greece. Palliat Support Care. 1-17. doi: 10.1017/S1478951520000528. Online ahead of print. PMID: 32594950.

961. Mentessidou A, Livani A, Chrousos G, Mirilas P. (2020) Ileocecal Valve Removal Reverses the Constipating Effects of Loperamide in Rats. J Surg Res. 255:371-377. doi: 10.1016/j.jss.2020.05.002. Online ahead of print. PMID: 32599457

962. Anesiadou S, Makris G, Michou M, Bali P, Papassotiriou I, Apostolakou F, Korkoliakou P, Papageorgiou C, Chrousos G, Pervanidou P. (2020) Salivary cortisol and alpha-amylase daily profiles and stress responses to an academic performance test and a moral cognition task in children with neurodevelopmental disorders. Stress Health. doi: 10.1002/smi.2971. Online ahead of print. PMID: 32608561

963. Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A, Bergström A, Bird PK, Brescianini S, Ní Chaoimh C, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Costet N, Criswell R, Crozier S, Eggesbø M, Fantini MP, Farchi S, Forastiere F, van Gelder MMHJ, Georgiu V, Godfrey KM, Gori D, Hanke W, Heude B, Hryhorczuk D, Iñiguez C, Inskip H, Karvonen AM, Kenny LC, Kull I, Lawlor DA, Lehmann I, Magnus P, Manios Y, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Rusconi F, Santos AC, Sørensen TIA, Standl M, Stoltenberg C, Sunyer J, Thiering E, Thijs C, Torrent M, Vrijkotte TGM, Wright J, Zvinchuk O, Gaillard R, Jaddoe VWV. Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births. (2020). PLoS Med. 2020 Aug 18;17(8): e1003182. doi: 10.1371/journal.pmed.1003182. eCollection 2020 Aug. PMID: 32810184

964. Kapogiannis A, Makris G, Darviri C, Artemiadis A, Klonaris D, Tsoli S, Bachourou T, Stefanaki C, Papanikolaou K, Chrousos G & Pervanidou P (2020) The Greek Version of the Vanderbilt ADHD Diagnostic Parent Rating Scale for Follow-up Assessment in Prepubertal Children with ADHD. International Journal of Disability, Development and Education, DOI: 10.1080/1034912X.2020.1802647

965. Theodoropoulou KT, Dimitriadis GD, Tentolouris N, Darviri C, Chrousos GP (2020) Diabetes distress is associated with individualized glycemic control in adults with type 2 diabetes mellitus. Hormones (Athens). 2020 Aug 25. doi: 10.1007/s42000-020-00237-3. Online ahead of print. PMID: 32844383

966. Mentessidou A, Salakos C, Chrousos G, Kanaka-Gantenbein C, Kostakis A, Mirilas P. Morphologic alterations of the genital mesentery implicated in testis nondescent in rats prenatally exposed to flutamide. Andrology. 2020 Sep 18. doi: 10.1111/andr.12903. Online ahead of print. PMID: 32946666 2

967. Michas G, Magriplis E, Panagiotakos D, Chourdakis M, Micha R, Filippatos G, Zampelas A, Dimakopoulos I, Karageorgou D, Mitsopoulou AV, Bakogianni I, Ntouroupi T, Tsaniklidou SM, Argyri K, Fappa E, Theodoraki EM, Trichia E, Sialvera TE, Varytimiadi A, Spyreli E, Koutelidakis A, Karlis G, Zacharia S, Papageorgiou A; Advisory Committee, Chrousos GP, Dedoussis G, Dimitriadis G, Manios Y, Roma E. Heart failure in Greece: The Hellenic National Nutrition and Health Survey (HNNHS). Hellenic J Cardiol. 2020 Sep 14:S1109- 9666(20)30191-3. doi: 10.1016/j.hjc.2020.08.007. Online ahead of print.

B. REVIEWS-CHAPTERS-LETTERS (*PEER REVIEWED)

1. Moutsopoulos HM, Chrousos GP, Papavassiliou JT. (1976) Autoimmunity and Slow Viruses. Materia Medica Graeca. 4(1):76-84.

2. Moutsopoulos HM, Chrousos GP, Papavassiliou JT. (1976) Humoral Thymic Products (Thymosin- Thymopoietin): Reality and Perspective. Materia Medica Graeca. 4(1): 85-89.

3. Chrousos GP. (1976) Bacteriocinogeny in Salmonellae. Doctorate Thesis, Athens University.

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4. Karatzas NB, Chrousos GP. (1976) The Adrenergic Neurochemical Transmission and the Drugs that Influence It. Iatriki. 30:311-325.

5. Chrousos GP, Karatzas NB. (1977) The Systolic Intervals In Hemodialysis. Changes Related to Starling's Law. Hellenic Cardiological Review (Athens). 18: 225-231.

6. Papadoyiannis DE, Clouvas P, Chrousos GP, Karatzas NB. (1977) A Blind Comparative Trial of a Beta- Blocker (timolol), a Diuretic and a Combination of the Two in the Treatment of Hypertension. Iatriki. 32: 391- 395.

7. Chrousos GP, Karatzas NB. (1977) The Problem Oriented System and Its Usefulness. Iatriki. 31: 348352.

8. Cornblath MD, Chrousos GP, Adams A. (1979) Hormone Interactions and Glucose Homeostasis. Acta Paediatrica Belg. 32: 231-238.

9. Chrousos GP, Greydanus D. (1981) Adolescent Medicine: Necessity and Perspectives. Iatriki. 40: 252-257.

10. Chrousos GP, Cutler GB, Simons S, Pons M, Moriarty RM, Loriaux DL. (1982) Development of Antiglucocorticoids with Potential Clinical Usefulness. In: Progress in Research and Clinical Applications of Corticosteroids, Eds. H.J. Lee, and T.J. Fitzerald, Heyden and Son Co., Philadelphia, p. 152-156.

11. Lipsett MB, Chrousos GP, Loriaux DL. (1982) Glucocorticoid Receptor Defects: Studies in Humans and a Primate Model in "Proceedings of the International Symposium on Hormone Receptors and Receptor Diseases." Excerpta Medica, Amsterdam, H. Imura and H. Kuzua (Eds.) p. 187-193.

12. Chrousos GP, Munabi A, Cutler GB Jr, Loriaux DL. (1982) Diagnosis of Late-Onset 21- Hydroxylase Deficiency by Plasma 17-Hydroxyprogesterone Response to ACTH. Ann Int Med. (Letter to the Editor) 97: 281-282.

13. Chrousos GP, Loriaux DL, Brandon D, Merriam GR, Johnson EO, Lipsett MB. (1983) Primary Cortisol Resistance: A Familial Syndrome and an Animal Model. J Steroid Biochem. 19: 567-576.

14. Chrousos GP, Cutler GB Jr, Sauer M, Simons SS Jr, Loriaux DL. (1983) Development of Glucocorticoid Antagonists: Pharmacol Ther. 20(2): 263-281.

15. Chrousos GP. (1983) Pathophysiology of the Endocrine Glands. In: "Basic Principles of Pathophysiology" Eds. H.M. Moutsopoulos and D.S. Emmanuel, Litsas Press, Athens. p. 116-168.

16. Chrousos GP, Schulte HM, Loriaux DL, Cutler GB Jr, Gold PW. (1983) Corticotropin Releasing Factor: Basic and Clinical Studies. Psychopharmacol Bull. 19: 416-421.

17. Becker L, Gold PW, Chrousos GP. (1983) Analogies betweeen Cushing's Disease and Depression: A Case Report. General Hospital Psychiatry. 5: 89-91.

18. *Schulte HM, Chrousos GP, Chatterji DC, Gold PW, Oldfield EH, Loriaux DL. (1983) Safety of Corticotropin-Releasing Factor. The Lancet Vol. I (o 8335) p. 1222 (Letter to the Editor).

19. Healy DL, Hall NR, Schulte HM, Chrousos GP, Goldstein AL, Loriaux DL, Hodgen GH. (1984) Pituitary Responses to Acute Administration of Thymosin in Prepubertal Primates. In: "Thymic Hormones and Lymphokines, Ed. Alan Goldstein, Plenum Press, New York, p. 365-374.

20. *Gold PW, Chrousos GP, Kellner C, Post R, Schulte H, Oldfield EH, Loriaux DL. (1984) Basic and Clinical Studies with Corticotropin Releasing Factor: Psychiatric Implications. Am J Psychiatry. 141: 619 627.

21. Chrousos GP, Tomita M, Brandon D, Loriaux DL, Lipsett MB. (1984) Glucocorticoid Insensitivity in Man and Nonhuman Primates. In: Labrie, F. and Prouix, L. (Eds.) Proceedings of the 7th International Congress of 83

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Endocrinology, Elsevier Science Pub., Amsterdam. p. 853-856.

22. Crawley JN, Ninan PT, Pickar D, Chrousos GP, Scolnick P, Paul SM. (1984) Behavioral and A Physiological Responses to Benzodiazepine Receptor Antagonists. Psychopharmacol Bull. 20: 403-407.

23. Schulte HM, Chrousos GP, Reinwein D, Loriaux DL. (1984) Der Kortikotropin-Releasing- Faktorstimulations- test inder Differential diagnose des Cushing-Syndroms. Verhandlungender Deutschen Gesellschaft fur Innere Medizin. Endokrinologie II 90: 508-511.

24. Chrousos GP, Nieman L, Nisula B, Schulte HM, Oldfield EH, Gold PW, Cutler GB Jr, Loriaux DL. (1984) Corticotropin-releasing Factor Stimulation Test. (Letter to the Editor). N Engl J Med. 311:472-473.

25. Chrousos GP, Nieman L, Healy D, Spitz I, Cutler GB Jr, Brandon D, Merriam GR, Hodgen G, Bardin CW, Loriaux DL. (1984) Antiglucocorticoids: General Aspects and Clinical Implications. In: Glucocorticoids: Research and Therapy. Eds. H. Fehm, J. Kobberling, and H. Kruskemper Perimed Fachbush, Verlagsgesellschaft, Erlangen. p. 54-71.

26. Chrousos GP, Calabrese JR, Loriaux DL, Schuermeyer T, Avgerinos P, Cutler GB Jr, Gold PW. (1985) Corticotropin Releasing Factor: Basic Studies and Clinical Implications. Prog in Neuro-Psychopharmacol and Biol Psychiat. 9: 349-359.

27. Hall N, McGillis JP, Spangelo BL, Healy DL, Chrousos GP, Schulte HM, Goldstein AL. (1985) Thymic Hormone Effects on the Brain and Neuroendocrine Circuits. In: Neural Modulation of Immunity. Eds. R. Guillemen, M. Cohen and T. Melnechuk, Raven Press, New York p. 179-193.

28. Lipsett MB, Chrousos GP, Brandon DD, Tomita M, Loriaux DL. (1985) The Defective Glucocorticoid Receptor in Man and Nonhuman Primates. Rec Prog Horm Res. 41: 199-247.

29. Udelsman R, Gallucci TW, Gold PW, Renquist DL, Loriaux DL, Chrousos GP. (1985) Human Corticotropin Releasing Hormone as a Vasodilator Causing Systemic Hypotension. In: The Adrenal Gland and Hypertension. F. Mantero, Biglieri E., Funder, J. and Scoggins, B. (Eds) Serono Symposia Series, Vol. 27, Raven Press, New York, 219-224.

30. *Gold PW, Chrousos GP. (1985) Clinical Studies with Corticotropin Releasing Factor: Implications for the Diagnosis and Pathophysiology of Depression, Cushing's Disease and Adrenal Insufficiency. Psychoneuro- endocrinology (awarded the Kurt Richter Prize for Psychoneuro-endocrinology) 10: 401-419.

31. Chrousos GP, Evans M, McCluskey J, Fletcher J, Loriaux DL, Schulman J. (1985) Prenatal Treatment of Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY. 458: 156- 164

32. Nieman LK, Chrousos GP, Kellner C, Spitz I, Nisula BC, Cutler GB Jr, Merriam GR, Bardin CW, Loriaux DL. (1985) Use of the Glucocorticoid Antagonist RU 486 in the Treatment of Cushing's Syndrome. In: The Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New York. 339-345.

33. Nieman LK, Healy D, Spitz I, Merriam R, Bardin CW, Loriaux DL, Chrousos GP. (1985) Use of Single Doses of the Antiprogesterone Steroid RU 486 for Induction of Menstruation in Normal Women. In: The Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New York 279-283.

34. Nottelman ED, Susman EJ, Blue JH, Inoff GE, Dorn LD, Cutler GB Jr, Loriaux DL, Chrousos GP. (1985) Gonadal and Adrenal Hormone Correlates of Adjustment in Early Adolescence. In: Biological-psychosocial Interactions in Early Adolescence: A Life-span Perspective. Eds. R.M. Lerner and T.T. Foch. Erlbaum, Hillsdale, N.J. p. 303-323.

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35. Oldfield EH, Chrousos GP, Nieman LK, Schaaf M, Cutler GB Jr, Loriaux DL, Doppman JL. (1985) Inferior Petrosal Venous Sampling in Lateralization of ACTH-secreting Pituitary Microadenomas. N Engl J Med (Letter to the Editor) 312: 1457-1458.

36. Udelsman R, Loriaux DL, Chrousos GP. (1985) Reevaluation of the Role of Glucocorticoids in Surgical Stress. Surgical Forum. 36: 18-20.

37. Gold PW, Kling M, Calabrese JR, Gallucci WT, Kellner CH, Post RM, Cutler GB, Avgerinos PC, Loriaux DL, Chrousos GP. (1985) Clinical Applications of Corticotropin Releasing Factor. In: Nemeroff, C.B., (Ed): Handbook of Clinical Neuroendocrinology. Raven Press, New York.

38. *Chrousos GP, Schuermeyer T, Oldfield E, Doppman J, Schulte HM, Gold PW, Loriaux DL. (1985) The Clinical Applications of Corticotropin-Releasing Factor. A Conference of the Combined Clinical Staff of the National Institutes of Health. Ann Int Med 102: 344-358.

39. Lipsett MB, Tomita M, Brandon D, Loriaux DL, Chrousos GP. (1986) Cortisol Resistance in Man. In: Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds) Steroid Hormone Resistance: Mechanisms and Clinical Aspects. Plenum Press, New York, p. 97-110.

40. Winterer J, Chrousos GP, Loriaux DL, Cutler GB. (1986) The Adrenal Suppressive Effect of Hydrocortisone in Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY 458: 182- 192.

41. Lipsett MB, Chrousos GP, Loriaux DL. (1986) The Steroid Binding Proteins in the Syndrome of Glucocorticoid Resistance and in New World Primates. In: The Role of Receptors in Biology and Medicine. B. O'Malley and A. Gotto (Eds). Raven Press, New York p. 51-61.

42. Chrousos GP, Loriaux DL, Tomita M, Brandon D, Lipsett MB. (1986) The New World Primates as Animal Models of Cortisol Resistance. In: Chrousos G.P., Loriaux D.L., Lipsett M.B., (Eds). Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Plenum Press, New York, p. 129-144.

43. Chrousos GP, Loriaux DL. (1986) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel, W.B. Saunders Co., Philadelphia p. 499-502.44. Gold P.W., Calabrese J., Kling M., Avgerinos P., Khan I., Gallucci W.T., Tomai T., Chrousos G.P. (1986) Abnormal Pituitary-Adrenal Responses to Corticotropin Releasing Factor in Depression. Prog Neuropsychopharmacol Biol Psychiatry. 10: 57-65.

44. Winterer J, Cutler GB Jr, Chrousos GP, Feuillan PP, Loriaux DL. (1986) Management of CongenitalAdrenal Hyperplasia. J Pediatrics. (Letter to the Editor) 109: 389-90.

45. Chrousos GP, Maclusky N, Brandon D, Tomita M, Loriaux DL, Lipsett MB. (1986) Progesterone Resistance. In: Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds). Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Plenum Press, New York, p. 317-328.

46. Gold PW, Kling M, Calabrese J, Kellner C, Roy A, Gwirtsman H, Post RM, Pickar D, Avgerinos PC, Loriaux DL, Chrousos GP. (1987) Corticotropin Releasing Factor in the Pathophysiology of Hypercortisolism in Depression. In: Hormones and Depression, U. Halbreich (Ed) Raven Press, New York. 77-89.

47. Chrousos GP, Loriaux DL. (1987) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel. W.B. Saunders Co., Philadelphia p. 495-498.

48. Susman E, Nottelman E, Inoff G, Dorn L, Chrousos GP. (1987) Hormonal Influences on Aspects of Psychological Development. J Adol Health Care. 8: 492-504.

49. Chrousos GP, Luger A, Avgerinos PC, Kling M, Oldfield E, Nieman LK, Schuermeyer T, Loriaux DL, Gold PW. (1987) Corticotropin Releasing Hormone: Relevance to Physiology and Pathophysiology. In: Recent Advances in Adrenal Regulation and Function, Raven Press, New York, 121-135. 85

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50. Nieman LK, Udelsman R, Loriaux DL, Chrousos GP. (1987) Antiglucocorticoids:. In: Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 235-242.

51. Udelsman R, Loriaux DL, Chrousos GP. (1987) Surgical Stress: The Role of Glucocorticoids and Catecholamines. In: D'Agata R., and G.P. Chrousos (Eds) Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 253-263.

52. Calogero A, Gallucci W, Tomai T, Loriaux DL, Chrousos GP, Gold PW. (1987) The GABA/Benzodiazepine System is Involved in the Regulation of Hypothalamic CRH Secretion In Vitro. In: D'Agata R., and Chrousos G.P. (Eds) Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 279-284.

53. Gold PW, Kling MA, Calabrese JR, Post RM, Roy A, Nieman LK, Cutler GB Jr, Loriaux DL, Chrousos GP. (1987) Corticotropin Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. (Letter to the Editor) N Engl J Med. 316: 218-219.

54. Laue L, Chrousos GP. (1987) Antiinflammatory Steroid Action: Receptor-mediated Effects on Prostanoid Synthesis. In: D'Agata R. and G.P. Chrousos (Eds). Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 293-302.

55. Gold PW, Gwirtsman H, Brandt H, Jimerson D, Loriaux DL, Chrousos GP. (1987) Abnormal Hypothalamic Pituitary-Adrenal Function in Anorexia Nervosa. (Letter) N Engl J Med. 316: 219-220.

56. Gold PW, Kling MA, Khan J, Calabrese JR, Kalogeras K, Post RM, Avgerinos P, Loriaux DL, Chrousos GP. (1987) Corticotropin Releasing Hormone: Relevance to Normal Physiology and to the Pathophysiology and Differential Diagnosis of Hypercortisolism and Adrenal Insufficiency. In: Hypothalamic Dysfunction in Neuropsychiatric Disorders. Eds. D. Nerozzi, F.K. Goodwin and E. Costa. In the series: Advances in Biochemical Psychopharmacology, Vol 43, Raven Press, NY pp. 183-200.

57. Schürmeyer TH, Schulte HM, Avgerinos P, Tomai TP, Loriaux DL, Gold PW, Chrousos GP. (1987) Pharmacology of Ovine and Human CRH. Horm Metabol Res. 16: 24-30.

58. Avgerinos P, Schuermeyer T, Udelsman R, Nieman LK, Gold PW, Loriaux DL, Chrousos GP. (1987) Human Corticotropin Releasing Factor as a Tool for Studying the Pulsatile Function of the Hypothalamic-pituitary- adrenal Axis. In: W. Crowley and J.F. Hofler (Eds) Episodic Hormone Secretion: Methods of Analysis and Normative Data. Churchill Livingstone, New York p. 389-401.

59. Peacock J, Laue L, Chrousos GP, Gallucci W, Norton N. (1987) Glucocorticoid Receptor Mediates Rat Sarcoma Growth. Surgical Forum 38: 396-398.

60. *Gold PW, Goodwin F, Chrousos GP. (1988) Clinical and Biochemical Manifestations of Depression: Relationship to the Neurobiology of Stress. (Part I) N Engl J Med. 319: 348-353.

61. Chrousos GP. (1988) Endocrine Tumors, In: Pizzo P.A. and Poplack D.G. (Eds) Principles and Practice of Pediatric Oncology. J.B. Lippincott Co., New York. 733-757.

62. Chrousos GP, Loriaux DL. (1988) Cushing's Syndrome. In: Conn's Current Therapy, Ed. R.E. Rakel, W.B. Saunders Co., New York. 525-529.

63. Margioris A, Grino M, Gold PW, Rabin D, Chrousos GP. (1988) Human Placenta and the Hypothalamic- pituitary-adrenal Axis. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv Exp Med Biol. 245: 389-398.

64. Chrousos GP, Loriaux DL, Gold PW. (1988) The Concept of Stress and Its Historical Development. In: Mechanisms of Physical and Emotional Stress, Plenum Publ Corp New York. Adv Exp Med Biol. 245: 3-7.

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65. Rabin D, Gold PW, Margioris A, Chrousos GP. (1988) Stress and Reproduction: Interactions Between the Stress and Reproductive Axes. In: Mechanisms of Physical and Emotional Stress, Plenum Publ Corp New York. Adv Exp Med Biol. 245: 377-387.

66. Nieman LK., Loriaux DL, Chrousos GP. (1988) Corticotropin Releasing Factors. In: Central Nervous System Endocrinology. M. Cohen and P. Foa (Eds). Springer-Verlag Co., New York, NY 14-45.

67. Bernardini R, Luger A, Gold PW, Chiarenza A, Legakis J, Chrousos GP. (1988) Cytokines Stimulate Pituitary-adrenal Function via Activation of the CRH Neuron. In: New Trends in Brain and Female Reproductive Function. F. Petraglia (Ed) CIG Edizioni Internationali, Milan p. 35-39.

68. Chrousos GP, Laue L, Kawai S, Nieman LK, Udelsman R, Loriaux DL. (1988) Glucocorticoids and Glucocorticoid Antagonists: Lessons from RU 486. Kidney International Vol. 34, Suppl 26, p. S-18-S-23.

69. Laue L, Loriaux DL, Chrousos GP. (1988) Glucocorticoid Antagonists and the Role of Glucocorticoids at the Resting and Stress State. In: Chrousos G.P., Loriaux D.L. and Gold P.W. (Eds) Mechanism of Physical and Emotional Stress. Plenum Press, New York, NY. Adv Exp Med Biol. 245: 225-235.

70. Gold PW, Pigott TA, Kling MK, Kalogeras K, Chrousos GP. (1988) Basic and Clinical Studies with Corticotropin Releasing Hormone: Implications for a Possible Role in Panic Disorder. Psychiatr Clin North America Vol. 11(2) 327-334.

71. Calogero A, Bernardini R, Gold PW, Chrousos GP. (1988) Regulation of CRH Secretion in Vitro: Potential Clinical Implications. In: Mechanisms of Physical and Emotional Stress. Plenum Publ., New York. Adv Exp Med Biol. 245: 167-181.

72. Udelsman R, Chrousos GP. (1988) Hormonal Response to Surgical Stress. In: Mechanisms of Physical and Emotional Stress. Plenum Publ., New York. Adv Exp Med Biol. 245: 267-272.

73. Luger A, Deuster PA, Gold PW, Loriaux DL, Chrousos GP. (1988) Hormonal Responses to the Stress of Exercise. Adv Med Biol. 245: 273-283.

74. Susman EJ, Nottelman ED, Dorn LD, Inoff-Germain G, Chrousos GP. (1988) Physiological and Behavioral Aspects of Stress in Adolescence. In: Mechanisms of Physical and Emotional Stress. Plenum Press New York. Adv Exp Biol Med. 245: 341-352.

75. Gold PW, Whitfield HJ, Kling MA, Demitrack MA, Brandt HA, Chrousos GP. (1988) The Relevance of Corticotropin Releasing Hormone to Normal Physiology and to Pathophysiology of Adrenal Function. In A.F. Schatzberg and C.B. Nemeroff (eds) The Hypothaamic-Pituitary-Adrenal Axis. Physiology, Pathophysiology and Psychiatric Implications. Raven Press, New York, p. 101-113.

76. Gold PW, Kling MA, Demitrack M, Whitfield HJ, Kalogeras K, Loriaux DL, Chrousos GP. (1988) Clinical Studies with Corticotropin Releasing Hormone: Implications for Hypothalamic-Pituitary-Adrenal Dysfunction in Depression and Related Disorders. In: Ganten D., and Pfaff D. (eds) Neuroendocrinology of Mood. Current Topics in Endocrinology Vol. 8, Springer-Verlag, New York p. 55-77.

77. Gold PW, Kling M, Whitfield H, Rabin D, Margioris A, Kalogeras D, Demitrack M, Loriaux DL, Chrousos GP. (1988) The Clinical Implications of Corticotropin Releasing Hormone. In: Mechanisms of Physical and Emotional Stress. Plenum Publ. New York. Adv. Exp. Biol. Med. 245: 507-519.

78. Brandon DD, Markwick A, Chrousos GP, Loriaux DL. (1988) Glucocorticoid Resistance in a Family and New World Primates. Cancer Res. (suppl). 49: 2203S-2213S.

79. *Gold PW, Goodwin FK, Chrousos GP. (1988) Clinical and Biochemical Manifestations of Depression: Relationship to the Neurolobiology of Stress. (Part 2). N Engl J Med. 319: 413-420.

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80. Laue L, Kawai S, Udelsman R, Nieman LK, Brandon DD, Gallucci WT, Gold PW, Loriaux DL, Chrousos GP. (1989) Glucocorticoid Antagonists: Pharmacological Attributes of the Prototype Antiglucocorticoid RU 486. Chapter 13. In: Lichtenstein L.M., Claman H., Oronsky A. and Schleimer R.P. (Eds) Antiinflammatory Steroid Action: Basic and Clinical Aspects. Academic Press, NY p. 303-329.

81. Kamilaris T, Chrousos GP. (1989) Tests of Adrenal Function. In "Diagnostic Endocrinology" Eds W.T. Moore and R. Eastman. B.C. Decker Inc. Toronto, CA. 79-109.

82. Chrousos GP, Laue L, Nieman LK, Udelsman R, Kawai S, Loriaux DL. (1989) Clinical Applications of RU 486, A Prototype Glucocorticoid and Progestin Antagonist. In: F. Mantero R. Takeda, B.A. Scoggins, E.G. Biglieri and J. Funder (Eds) The Adrenal and Hypertension: From Cloning to Clinic. Serono Symposia Series, Raven Press, NY p. 273-284.

83. Chrousos GP, Gold PW. (1989) Clinical Implications of Corticotropin Releasing Hormone. F. Mantero and J. Funder (Eds) The Adrenal Cortex: From Cloning to Clinic. Serono Symposia Series, Raven Press, NY p. 259- 272.

84. Smith MA, Kling MA, Whitfield HJ, Brandt HA, Demitrack MA, Geracioti TD, Chrousos GP, Gold PW. (1989) Corticotropin Releasing Hormone. From Endocrinology to Psychobiology. Horm Res. 31: 66-71.

85. Gold PW, Altemus M, Goodwin FK, Chrousos GP. (1989) Brain-Mind Interactions. N Engl J Med. (Letter to the Editor) 320: 869-870.

86. Kling MA, Whitfield HJ, Brandt HA, Demitrack MA, Kalogeras K, Geracioti TD, Perini GI, Calabrese JR, Chrousos GP, Gold PW. (1989) Effects of Glucocorticoid Antagonism with RU 486 on Pituitary-adrenal Function in Patients with Major Depression: Time-dependent Enhancement of Plasma ACTH Secretion. Psychopharmacology Bull. 25: 466-472.

87. Sternberg EM, Wilder RL, Chrousos GP, Gold PW, Young WS, Bernardni R, Calogero AE, Hill JM, Kamilaris T, Listwak SJ. (1988) The Role of the Hypothalamic-pituitary-adrenal Axis in Susceptibility to Arthritis. IN: Cushing's Syndrome and Other Hypercortisolemic States. Raven Press, New York. p. 183-188.

88. Bernardini R, Rabin D, Margioris A, Grino M, Gold PW, Chrousos GP. (1989) The Hypothalamic-pituitary- adrenal Axis in Aging. In: Psychoneuroendocrinology of Aging. Fidia Research Series Vol. 16 Springer Verlag, Padova, p. 75-81.

89. Kling MA, Perini GI, Demitrack MA, Geracioti T, Linnoila M, Chrousos GP, Gold PW. (1989) Stress- responsive Neurohormonal Systems and the Symptom Complex of Affective Disorder. Psychopharmacol Bull. 25: 12-18.

90. Chrousos GP, Udelsman R, Margioris A, Gold PW, Oldfield EH, Schuermeyer TH, Schulte HM, Dopman J, Loriaux DL. (1989) Corticotropin-releasing Factor. Physiological and Clinical Implications. In: E.E. Muller and R.M. MacLeod (Eds). Neuroendocrine Perspectives. Vol 7, page 49-76 Elsevier Biomedical Press, New York.

91. Cutler GB Jr, Schiebinger RJ, Albertson BD, Cassorla GB, Chrousos GP, Comite F, Booth JD, Levine J, Hobson WC, Loriaux DL (1990) The Adrenarche (Human and Animal). In: "Second International Conference on the Control of the Onset of Puberty", Eds M. Grumbach, P. Sizonenko, and M. Aubert. Williams and Wilkins, Baltimore, p. 506-533.

92. Loughlin T, Chrousos GP. (1990) Hypoaldosteronism, In: Becker K.L. (Ed) Principles and Practice of Endocrinology and Metabolism. J.B. Lippincott Co., New York. 643-649.

93. Cassorla F, Chrousos GP. (1990) The Adrenogenital Syndrome. In: Becker K.L. (ed.) Principles and Practice of Endocrinology and Metabolism. J.B. Lippincott Co., New York. 604-613.

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94. Bernardini R, Calogero AE, Gold PW, Chrousos GP. (1990) Mediators of the Immune Response. Relationships with Hypothalamis Corticotropin Releasing Hormone and Pituitary Adrenal Corticotropin. In: Cushing's syndrome and Other Hypercortisolemic States. Eds. D. Ludecke, G. Chrousos and G. Tolis. Raven Press, New York p. 15-20.

95. Luger A, Deuster P, Chrousos GP. (1990) Hypercortisolism of Exercise: In: Cushing's syndrome and Other Hypercortisolemic States. Eds: D. Ludecke, G. Chrousos and G. Tolis, Raven Press, New York p. 77-82.

96. Margioris AN, Brockmann G, Gomez MJ, Chrousos GP. (1990) Paracrine Effects of Placental Corticotropin Releasing Hormone. In: Cushing's Syndrome and Other Hypercortisolemic States. Eds: D. Ludecke, G Chrousos and G. Tolis, Raven Press, New York p. 189-192.

97. Meyerhoff JL, Oleshansky MA, Kalogeras KT, Mougey EH, Chrousos GP, Granger LG. (1990) Neuroendocrine Responses to Emotional Stress: Possible Interactions Between Circulating Factors and Anterior Pituitary Hormone Release. In Circulating Regulatory Factors and Neuroendocrine Function: Advances in Experimental Biology and Medicine, ed. by J.C. Porter and D. Jezova, Plenum Press, 274: 91-111.

98. Coutifaris C, Ringler GE, Reed K, Margioris A, Chrousos GP, Strauss JF III (1990) The Placenta and Stress: Effects of Adenylate Cyclase Activators and of Glucocorticoids on the Endocrine Function of Trophoblastic Cells in Culture. In: Neuroendocrine Regulation of Reproduction. Eds: S.S.C. Yen and W.W. Vale. Serono Symposia USA, Norwell, Mass. p. 95-103.

99. Chrousos GP. (1990) Glucocorticoid Resistance. Birth Defects Encyclopedia. Alan R. Liss. Inc. New York. 784-785.

100. Margioris AN, Chrousos GP. (1990) Cushing's syndrome: Diagnostic Evaluation. In: Endocrine Hypertension. E. Biglieri (editor), Raven Press, N.W. 99-111.

101. Sternberg E, Wilder R, Gold PW, Chrousos GP. (1990) A Defect in the Central Component of the Immune System-hypothalamic-pituitary-adrenal Axis Feedback Loop is Associated with Susceptibility to Arthritis and Inflammatory Disease. Ann New York Acad Sci. 594: 289-92.

102. Susman E, Nottelman E, Dorn L, Gold PW, Chrousos GP. (1989) The Physiology of Stress andBehavioral Development. In: Coping with Uncertainty: Biological, Behavioral and Developmental Perspectives. D.S. Palermo and J. Kagan (Eds). Lawrence Erlbaum Assoc., Inc., Hillsdale, N.J., 17-38.

103. Sternberg EM, Wilder RL, Chrousos GP, Gold P.W. (1991) Stress Responses and the Pathogenesis of Arthritis. In: Stress Neuropeptides, and Systemic Disease. Eds. J. A. McCubbin, P. Kaufman and C. Nemeroff, Academic Press, 287-300.

104. Hurley D, Chrousos GP. (1991) Glucocorticoid Resistance. Current Therapy in Endocrinology and Metabolism. W. Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 150-151.

105. Gomez MT, Chrousos GP. (1991) Cushing's Syndrome. Current Therapy in Endocrinology and Metabolism. W. Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 134-137.

106. Kamilaris T, Chrousos GP. (1991) Cushing's Syndrome in R-Rakel (Ed.) Conn's Current Therapy W.B. Saunders Co., Philadelphia, 572-578.

107. Gomez MT, Chrousos GP. (1991) Chronic Adrenal Insufficiency. In: Conn's Current Diagnosis. W.B. Saunders Co., Philadelphia, 865-868.

108. Laue L, Gold PW, Richmond A, Chrousos GP. (1991) The Hypothalamic-pituitary-adrenal Axis in Anorexia and Bulimia Nervosa In: L.A. Barness (Ed.), Advances in Pediatrics 287-316.

109. Flack M, Chrousos GP. (1993) Neoplasms of the Adrenal Cortex In: Cancer Medicine, R. Holland et al. (Eds.) 89

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Third Edition. Lea and Fibinger Inc., New York Vol 1, 1147-1153.

110. Liapi C, Chrousos GP. (1992) "Glucocorticoids". Chapter 41. In: Pediatric Pharmacology, S.J. Yaffe and J.V. Aranda (Eds). 2nd Edition Saunders Publ Co. New York 466-475.

111. Karalis K, Gold PW, Chrousos GP. (1992) Hypothalamic-pituitary-adrenal Function in Eating Disorders. In: Psychiatry: A World Perspective Vol. 2 Neurosciences in Psychiatry. C. Stefanis, C. Soldatos, A. Rabavilas. Excerpta Medica 537-544.

112. Stratakis C, Karl M, Hurley D, Accili D, Vamvakopoulos N, Rorer E, Constantine K, Taylor S, Chrousos GP. (1991) A Point Mutation in the Hormone Binding Domain of the Glucocorticoid Receptor in Familial Glucocorticoid Resistance. Horizons in Endocrinology. Eds., M. Maggi and V. Geenen, Serono Symposia Series, Vol. 76:3-8.

113. Nottelman E, Susman E, Chrousos GP. (1990) Hormones and Adjustment in Puberty. In: Adolescence and Puberty, J. Bancroft and J. Reinisch (Eds). Kinsey Institute Symposia Series 88-123.

114. Rabin D, Chrousos, GP. (1991) Adrenal Androgens In: Lerner R., Peterson A., and Brooks-Gunn J. Eds, The Encyclopedia of Adolescence. Garland Publ. New York. Vol. 1:53-55.

115. Rabin D, Chrousos GP. Gonadal Androgens. (1991) In: Lerner R., Petersen A and Brooks-Gunn J. Eds, The Encyclopedia of Adolescence. Garland Publ. New York. Vol 1:56-59.

116. Gold PW, Kling MA, Whitfield HJ, Demitrack MA, Kalogeras K, Loriaux DL, Chrousos GP. (1988) The Clinical Implications of Corticotropin Releasing Hormone. In: Progress in Endocrinology Imura H., Shizuma K, Yoshida S. (Eds) Elsevier Science Publishers, Excerpta Medica New York 897-914.

117. Margioris A, Stratakis C, Chrousos GP. (1991) Glucocorticoids and Other Adrenal Steroids. Chapter 35. In: Human Pharmacology: Molecular to Clinical. L. Winegard, T. Brody, J. Larner and A. Schwartz (Eds). Mosby Yearbook, St. Louis, p 484-493.

118. Johnson EO, Kamilaris TC, Chrousos GP, Gold PW. (1992) Mechanisms of Stress: A Dynamic Overview of Hormonal and Behavioral Homeostasis. J Neurosc Biobehav Rev. 16:115-130.

119. Perini GI, Kling MA, Calogero AE, Devinski O, Smith MA, Chrousos GP, Gold PW. (1990) Effects of Carbamazepine on the Hypothalamic-pituitary-adrenal Axis: Potential Relevance of its Mechanisms of Action. In: Canger R, Sacchetti E., Perini GI, Canevini MP, (Eds.) Carbamazepine: A Bridge between Epilepsy and Psychiatric Disorders. Origgio: Ciba-Geigy Edizioni, 119-123.

120. Chrousos GP. (1993) Endocrine Tumors, In: Pizzo P.A., and Poplack D.G. (Eds). Principles and Practice of Pediatric Oncology, J.B. Lippincott Co., New York, 2nd Edition 889-912.

121. *Chrousos GP, Gold PW. (1992). The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis. JAMA. 267:1244-1252.

122. Chrousos GP. (1992) Regulation and Dysregulation of the Hypothalamic-pituitary-adrenal Axis: The Corticotropin Releasing Hormone Perspective. Endocrinology and Metabolism Clinics of North America 21:833-858.

123. Chrousos GP, Dorn L. (1993) Puberty, Adolescence, and the Stress Response. In: Frajese G., Steinberger E. and Rodriguez R. (Eds) Reproductive Medicine. Serono Symposia Series, Raven Press, New York pp. 53-62.

124. Karl M, Chrousos GP. (1993) Familial Glucocorticoid Resistance: An overview. Exp. Clin. Endocrinol. 101:30-35.

125. *Sternberg EM, Chrousos GP, Wilder RL, Gold PW. (1992) The Stress Response and the Regulation of 90

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Inflammatory Disease: NIH Combined Clinical Staff Conference. Ann Int Med. 117:854-866.

126. Chrousos GP, Karl M. (1992) The Molecular Mechanisms of Glucocorticoid Resistance. In: Saez J. (Ed) Cellular and Molecular Biology of the Adrenal Cortex. John Libbey Eurotext Limited. London. Colloques INSERM 222:215-225.

127. Sharara FI, Chrousos GP, Patronas N. (1992) Watchful Waiting and Craniopharyngioma. (Letter to the Editor) Ann Int Med. 117:876-877.

128. Mastorakos G, Webster EL, Chrousos GP. (1993) Corticotropin-releasing Hormone and Its Receptors in the Ovary: Physiological Implications. Ann New York Acad Sci. 687:20-30.

129. Dorn LD, Chrousos GP. (1993) The Endocrinology of Stress and Stress System Disorders in Adolescence. In: R. Rosenfield (Editor) Adolescent Endocrinology. Endocrinology and Metabolism Clinics of North America 22:685-700.

130. Marini JC, Bordenick S, Heavner G, Rose SR, Chrousos GP. (1993) Evaluation of the Growth Hormone Axis in Osteogenesis Imperfecta. Am. J. Med. Genet. 45:261-264.

131. Karl M, Chrousos GP. (1995) Chapter 27, Molecular Aspects of Familial Glucocorticoid Resistance. In: B. Weintraub (Editor) Molecular Endocrinology: Basic Concepts and Clinical Correlations. Raven Press, New York, pp. 445-454.

132. *Chrousos GP, Detera-Wadleigh S, Karl M. (1993) NIH Conference of the Combined Clinical Staff: Syndromes of Glucocorticoid Resistance. Ann Int Med. 119:1113-1124.

133. Chicanza IC, Chrousos GP, Panayi GS. (1992) Abnormal Neurendocrine-Immune Communications in Patients with Rheumatoid Arthritis. Eu. J Clin Invest. 22:635-637.

134. Zeiger MA, Pass HI, Doppman JD, Nieman LK, Chrousos GP, Cutler GB, Jensen RT, Norton JA. (1992) Surgical Strategy in the Management of Non-Small Cell Ectopic Adrenocorticotropic Hormone Syndrome. Surgery 112:994-1000.

135. *Boumpas DT, Chrousos GP, Wilder RL, Cupps TR, Balow JE. (1993) NIH Conference of the Combined Clinical Staff. Glucocorticoid Therapy of Immune-Related Diseases: Basic and Clinical Correlates. Ann Inter Med. 119:1198-1208.

136. *Vamvakopoulos NC, Chrousos GP. (1994) Hormonal Regulation of Human Corticotropin Releasing Hormone Gene Expression. Implications for the Stress Response and Immune/Inflammatory Reaction. Endocrine Reviews. 15:409-420.

137. Karl M, Accili A, Chrousos GP. (1993) Familial Glucocorticoid Resistance and Its Molecular Basis. In: New Perspectives in Endocrinology, Serono Symposia, A. Debellis and K.B. Marschke eds., Raven Press, New York, Vol. 99, pp. 83-91.

138. Karl M, Schulte HM, Chrousos GP. (1994) Mutation Analysis of Steroid Hormone Receptors. In Neurobiology of Steroids, deKloet E.R. and W. Suntanto eds., Vol. of Methods in Neurosciences, Academic Press 22:226-241.

139. Friedman TC, Chrousos GP. (1993) Transsphenoidal Resection in Cushing's Disease: Definition of Success. (Letter to the Editor) Clinical Endocrinology. 39:701.

140. *Chrousos GP. (1995) The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation. New England Journal of Medicine. 332:1351-1362.

141. Margioris A, Gravanis A, Chrousos GP. (1994) Glucocorticoids and Mineralocorticoids. Chapter 35. In: 91

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Human Pharmacology: Molecular to Clinical. T. Brody, J. Larner, K. Minneman, H.C. Neu (Eds) Mosby- Yearbook, St. Louis p. 473-481.

142. Magiakou MA, Chrousos GP. (1994) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid Withdrawal. Current Therapy in Endocrinology and Metabolism. Mosby-Year Book Inc., St. Louis p.120- 124.

143. Arai K, Chrousos GP, (1994) Glucocorticoid Resistance. Chapter 5, Baillere's Clinical Endocrinology and Metabolism. Vol. 8, No.2. Baillere Tindal London p. 317-331.

144. Arai K, Chrousos GP. (1995) Syndromes of Glucocorticoid and Mineralocorticoid Resistance. Steroids 60:173-179.

145. Magiakou MA, Chrousos GP. (1996) Glucocorticoid Therapy and Withdrawal. Chapter 6 In: R.C.Bone. Current Practice of Medicine. Current Medicine, Inc., Philadelphia, IV 6.1-6.6.

146. Bamberger CM, Chrousos GP. (1994) Glucocorticoid Resistance. (Letter to the Editor) Annals of Internal Medicine 102:1047-1048.

147. Stratakis CA, Mastorakos G, Chrousos GP. (1994) Interleukin-6 Elevation in Critically Ill Infants with Sepsis and Necrotizing Enterocolitis. (Letter to the Editor) J Pediatrics. 125:504.

148. Tsigos C, Chrousos GP. (1994) Physiology of the Hypothalamic-Pituitary-Adrenal Axis in Health and Dysregulation in Psychiatric and Autoimmune Disorders. Endocrin Metab Clin N Amer. 23:451-466.

149. Chrousos GP. (1996) Chapter 1. Organization and Integration of the Endocrine System. In: Pediatric Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14.

150. Magiakou MA, Chrousos GP. (1994) Diagnosis and Treatment of Cushing's Disease. In: The Pituitary Gland, H. Imura (ed), 2nd Edition, Raven Press: New York, p. 491-508.

151. Mastorakos G, Chrousos GP (1995) Chapter 79, Adrenal Hyperandrogenism. In: Reproductive Endocrinology, Surgery, and Technology. Adashi E., Rock J., and Rosenwaks Z. eds. Raven Press, New York, p. 1539-1553.

152. Stratakis CA, Karl M, Schulte HM, Chrousos GP. (1994) Glucocorticoid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology. Ann NY Acad Sci. 746:362-376.

153. Tsigos C, Chrousos GP. (1995) Stress, Endocrine Manifestations and Diseases. Chapter 3. In: Handbook of Stress Medicine. Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 61-65.

154. Stratakis CA., Gold PW, Chrousos GP. (1995) Neuroendocrinology of Stress: Implications for Growth and Development. Hormone Research. 43:163-167.

155. Tsigos C, Chrousos GP. (1995) Clinical Presentation, Diagnosis, and Treatment of Cushing's Syndrome. Current Opinion in Endocrinology and Diabetes, 2:203-213.

156. Papanicolaou D, Chrousos GP. (1995) Interactions of the Endocrine and Immune Systems in Children and Young Adults. Current Opinion in Pediatrics. 7:440-444.

157. Karl M, Chrousos GP. (1996) Experimental and Clinical Models of CRH-Induced Pituitary Tumors. In: Oncogenesis and Molecular Biology of Pituitary Tumors. S. Melmed (ed) Front. Horm Res Vol 20 Karger Basel. 54-71.

158. Tsigos C, Papanicolaou D, Chrousos GP. (1995) Advances in the Diagnosis and Treatment of Cushing's Syndrome. Bailliere's Clinical Endocrinology and Metabolism. 9:315-336.

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159. Tsigos C, Arai K, Latronico AC, Webster E, Chrousos GP. (1995) Receptors for Melanocortin Peptides in the Hypothalamic-Pituitary-Adrenal Axis and Skin. Ann NY Acad Sci. 771:352-363.

160. Tsigos C, Chrousos GP. (1995) The Neuroendocrinology of the Stress Response. Chapter 6. In: NIDA Alcohol Research Monograph: Stress, Gender, and Alcohol Seeking Behavior. W.A. Hunt and S. Zachari, ed., CSR, Inc., Washington, D.C., 29:103-124.

161. Tsigos C, Chrousos GP. (1996) The Neuroendocrinology of Stress. In: Women, Health and Disability. D. Krotowski, M. Nosek, M. Turk (eds), Brookes Publishers, Baltimore, 203-221

162. Flack MR, Chrousos GP. (1996) Neoplasms of the Adrenal Cortex. Chapter 101. Cancer Medicine, 4th Edition. R. Holland et al. (eds) Lea and Fibinger, New York, 1563-1570.

163. Peeke PM, Chrousos GP. (1995) Hypercortisolism and Obesity. Ann NY Acad. Sci. 771:665-676.

164. Stratakis CA, Chrousos GP. (1995) Neuroendocrinology of Stress and the Immune Response. In: Root A., ed. Proceedings of the 1994 NCGS Investigators Meeting. Gardiner-Caldwell, Califon, NJ, p. 4-7.

165. Stratakis CA, Vamvakopoulos NC, Chrousos GP. (1995) Corticotropin-Releasing Hormone, Stress and Depression. In: Bailly D., ed. Neuroendocrine Aspects of Mood Disorders. Ardix Médical, Levallois p. 119- 152 (in french).

166. Stratakis CA, Chrousos, GP. (1997) Endocrine Tumors. In: Pizzo P.A., Poplack D.G., eds. Principles and Practice of Pediatric Oncology, 3rd edition. J.B. Lippincott Raven Publishers, Philadelphia, p. 947-976.

167. Tsigos C, Kamilaris T, Chrousos GP. (1996) Adrenal Diseases. In: Moore W.T., Eastman R., eds. Diagnostic Endocrinology, 2nd edition. B.C. Decker Inc., Toronto, p. 123-156.

168. Tsigos C, Chrousos GP. (1996) Differential Diagnosis and Management of Cushing's Syndrome. Ann Rev Med 47:443-61

169. Chrousos, GP. (1995) Cytokine Therapy in Septic Shock. (Letter to the Editor) N Engl J Med. 333:942-943.

170. Bamberger CM, Chrousos GP. (1995) The Glucocorticoid Receptor and RU 486 in man. Ann NY Acad Sci. 761;296-311.

171. Bamberger CM, Bamberger AM, Chrousos GP. (1995) Dominant Negative Inhibitors of the Glucocorticoid Receptor. In: De Bellis A., Schipani E. (eds.) Frontiers in Endocrinology, Vol. 14. Serono Symposia Publication, Rome, Italy, pp. 129-139.

172. Stratakis CA, Chrousos GP. (1995) Neuroendocrinology and Pathophysiology of the Stress System. Ann NY Acad Sci. 771:1-18.

173. Cizza G, Gold PW, Chrousos GP. (1995) Aging is Associated in the 344/N Fischer Rat with Decreased Stress Responsivity of Central and Peripheral Catecholaminergic Systems and Impairment of the Hypothalamic- Pituitary-Adrenal Axis. Ann NY Acad Sci. 771:491-511.

174. Crofford LJ, Sano H, Karalis K, Webster EA, Friedman TC, Chrousos GP, Wilder RL. (1995) Local Expression of Corticotropin-Releasing Hormone in Inflammatory Arthritis. Ann NY Acad Sci. 771:459-471.

175. Mastorakos G, Magiakou MA, Chrousos GP. (1995) Effects of the Immune/Inflammatory Reaction on the Hypothalamic-Pituitary-Adrenal Axis. Ann NY Acad Sci. 771:438-448.

176. Carter CS, DeVries AC, Taymans SE, Roberts RL, Williams JR, Chrousos GP. (1995) Adrenal Corticoid Hormones and the Development and Expression of Mammalian Monogamy. Ann NY Acad Sci. 771:82-91.

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177. Reincke M, Lehmann R, Karl M, Magiakou MA, Chrousos GP, Allolio B. (1995) Severe Illness. Neuroendocrinology. Ann NY Acad Sci. 771:556-569.

178. *Latronico AC, Chrousos GP. (1997) Adrenocortical Tumors (Extensive Personal Experience Article). J Clin Endocrinol Metab. 82:1317-1324.

179. Gold PW, Licinio J, Wong ML, Chrousos GP. (1995) Corticotropin Releasing Hormone in the Pathophysiology of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs. Ann NY Acad Sci. 771:716-729.

180. Marini JC, Bordenick S, Chrousos GP. (1995) Endocrine Aspects of Growth Deficiency in OI. Connective Tissue Research. 31:S55-S57.

181. Masi A, Chrousos GP. (1996) The Hypothalamic-Pituitary-Adrenal-Glucocorticoid Axis in Rheumatoid Arthritis. (Editorial) J Rheumatol. 23:577-581.

182. Chrousos GP, Castro M, Leung DYM, Webster E, Kino T, Bamberger C, Elliot S, Stratakis C, Karl M. (1996) Molecular Mechanisms of Glucocorticoid Resistance/Hypersensitivity. Am J Resp Crit Care Med. 154:S39- S44.

183. *Bamberger CM, Schulte H.M, Chrousos GP. (1996) Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity. Endo Rev. 17:221-244.

184. Torpy DJ, Chrousos GP. (1996) The Three-Way Interactions Between the Hypothalamic-Pituitary- Adrenal and Gonadal Axes and the Immune System. Ballière's Clinical Rheumatology. 10:181-198.

185. Masi AT, Chrousos GP. (1997) Dilemmas of Low-Dosage Glucocorticoid Therapy in Rheumatoid Arthritis: Considerations of Timing. (Leader) Annals of Rheumatic Diseases. 56:1-4.

186. Cizza G, Gold PW, Chrousos GP. (1997) High-Dose Transdermal Estrogen, Corticotropin- Releasing Hormone and Postnatal Depression (Letter to the Editor). J Clin Endocrinol Metab. 82:704.

187. Cizza G, Chrousos GP. (1997) Anxiety and Short Stature (Letter to Editor). Pediatrics. 99:500.

188. Gold PW, Wong M-L, Chrousos GP, Licinio J. (1996) Stress System Abnormalities in Melancholic and Atypical Depression: Molecular, Pathophysiological, and Therapeutic Implications (Editorial). Mol Psychiatry 1:257-264.

189. Cizza G, Chrousos GP. (1997) Adrenocorticotropic Hormone-Dependent Cushing's Syndrome: Chapter 2. Endocrine Neoplasms, Andrew Arnold, Ed. Klawer Academic Publishers, Boston, pp. 25-40.

190. Latronico AC, Chrousos GP. (1997) Neoplasms of the Adrenal Cortex. Chapter 11. In: Endocrine Neoplasms, Andrew Arnold, Ed., Klawer Academic Publishers, Boston, pp. 217-237.

191. Torpy D, Papanicolaou D, Chrousos GP. (1997) Sexual Dimorphism of the Human Stress Response May Be Due to Estradiol-mediated Stimulation of Hypothalamic Corticotropin-Releasing Hormone Synthesis. (Letter to the Editor) J Clin Endocrinol Metab. 82:982.

192. Dorn L, Chrousos GP. (1997) The Neurobiology of Stress: Understanding Regulation of Affect During Female Biological Transitions. Seminars in Reproductive Medicine. 15:29-45.

193. Stratakis CA, Chrousos GP. (1997) The Familial Lentiginosis Syndromes: Link to Inherited Neoplasias and Identification of a Genetic locus. Hellenic Medical Journal. 1:15-19.

194. Chrousos GP. (1997) The Neuroendocrinology of Stress: Its Relation to the Hormonal Milieu, Growth, and Development. Growth, Genetics & Hormones. 13:1-8. 94

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195. Stratakis CA, Chrousos GP. (1997) Chapter 13. Hypothalamic Hormones: GnRH, TRH, GHRH, SRIF, CRH, and Dopamine. Endocrinology: Basic and Clinical Principles, Conn P.M. and Melmed S. (Eds.), Humana Press, Totowa, NJ. 185-209.

196. Magiakou MA, Chrousos GP. (1997) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid Withdrawal. Current Therapy in Endocrinology and Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St. Louis, MO 138-142

197. De Castro M, Chrousos GP. (1997) Glucocorticoid Resistance. Current Therapy in Endocrinology and Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St. Louis, MO 188-189.

198. Torpy DJ, Chrousos GP. (1997) General Adaptation Syndrome: An Overview. Endocrinology of Critical Disease, Ober K.P. (Editor), Human Press, Totowa, NJ 1-24.

199. Chrousos GP. (1997) The Future of Pediatric and Adolescent Endocrinology. Ann New York Acad Sci. 816:4- 8.

200. Mastorakos G, Ghizzoni L, Webster EL, Chrousos GP. (1997) Autocrine-Paracrine Role of Ovarian Corticotropin-Releasing Hormone. Ann New York Acad Sci. 816:22-26.

201. Magiakou MA, Mastorakos G, Webster E, Chrousos GP. (1997) The Hypothalamic-Pituitary- Adrenal Axis and the Female Reproductive System. Ann New York Acad Sci. 816: 27-41.

202. Magiakou MA, Mastorakos G, Chrousos GP. (1997) Cushing Syndrome: Differential Diagnosis and Treatment. Wierman M.E. (Editor), Diseases of the Pituitary: Diagnosis and Treatment, Humana Press, Totowa, NJ 179- 202.

203. *Clauw DJ, Chrousos GP. (1997) Chronic Pain and Fatigue Syndromes: Overlapping Clinical and Neuroendocrine Features and Potential Pathogenic Mechanisms. NeuroImmunoModulation. 4:134-153.

204. *Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. (1998) The Pathophysiologic Roles of Interleukin-6 in Humans. Ann Intern Med. 128:127-137.

205. Chrousos GP. (1997) Adrenal Hyperandrogenism. In: Up-to-date in Endocrinology and Diabetes (CD ROM). Editor-in-Chief, Burton D. Rose. Endocrine Society. Bethesda, MD.

206. Licinio J, Gold PW, Chrousos GP, Sternberg EM. (1997) Forty Years of Neuroendocrinology (Editorial). Mol Psychiatry. 2:347-349.

207. Webster EL, Elenkov IJ, Chrousos GP. (1997) The Role of Corticotropin-Releasing Hormone in Neuroendocrine-Immune Interactions. Mol Psychiatry. 2:368-372.

208. Chrousos GP. (1997) Stress as a Medical and Scientific Idea and Its Implications. Advances in Pharmacology. 42:552-556.

209. Chrousos GP. (1997) Secondary Adrenal Insufficiency. In: The Diagnosis and Treatment of Pituitary Insufficiency, S.W.J. Lamberts (Editor), Bioscientifica, Bristol, UK 39-61.

210. Pillemer SR, Bradley LA, Crofford LJ, Moldofsky H, Chrousos GP. (1997) The Neuroscience and Endocrinology of Fibromyalgia. Arthritis & Rheumatism 40:1928-1939.

211. Stratakis CA, Chrousos GP. (1997) The Case of Urinary Growth Hormone (Editorial). Endocrine Practice. 3:389-391.

212. *Torpy DJ, Chrousos GP. (1997) Stress and Critical Illness: the Integrated Immune/Hypothalamic- Pituitary- 95

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Adrenal Axis Response. J Intensive Care Med. 12:225-238.

213. *Chrousos GP. (1998) Ultradian, Circadian and Stress-Related Hypothalamic-Pituitary-Adrenal Axis Activity: A Dynamic Digital-to-Analog Modulation (Editorial). Endocrinology. 139:437-440.

214. *Chrousos GP, Torpy D, Gold PW. (1998) Interactions Between the Hypothalamic-Pituitary- Adrenal Axis and the Female Reproductive System:Clinical Implications. Ann Intern Med. 129:229-240.

215. Bornstein SR, Torpy DJ, Chrousos GP, Licinio J, Engelmann L. (1997) Leptin Levels are Elevated Despite Low Thyroid Hormone Levels in the “Euthyroid Sick” Syndrome (Letter to the Editor). J Clin Endocrinol Metab. 82:4278-4279.

216. Chrousos GP. (1998) Stressors, Stress and Neuroendocrine Integration of the Adaptive Response: 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci. 851:311-335.

217. Shupnik MA, Chrousos GP, Siragy HM. (1997) Glucocorticoids and Mineralocorticoids. In: Human Pharmacology: Molecular to Clinical, Third Edition, T.M. Brody, J. Larner, K.P. Minneman (Eds), Mosby- Year Book, St. Louis, MO 485-497.

218. Tsigos C, Chrousos GP. (1998) ACTH Resistance Syndromes. In: G Proteins, Receptors, and Disease. A.M. Spiegel (Ed), Humana Press, Totowa, NJ 261-269.

219. Stratakis CA, Chrousos GP. (1998) Cushing Syndrome and Cushing Disease. In: Saunders Manual of Pediatric Practice. L. Finberg (Ed), W.B. Saunders Company, Philadelphia, PA 807-809.

220. *Chrousos GP, Gold PW. (1998) A Healthy Body in a Healthy Mind- and Vice Versa-: The Damaging Power of “Uncontrollable” Stress (Editorial). J Clin Endocrinol Metab. 83:1842-1845.

221. Chrousos GP, Stratakis CA. (1998) Carney Complex and the Familial Lentiginosis Syndromes: Link to Inherited Neoplasias and Developmental Disorders, and Genetic Loci. J Intern Med. 243:573-579.

222. Meduri GV, Chrousos GP. (1998) Duration of Glucocorticoid Treatment and Outcome in Sepsis: Is the Right Drug Used the Wrong Way? (Editorial). Chest. 114:355-360.

223. *Torpy DJ, Bornstein SR, Cizza G, Chrousos GP. (1998) The Effects of Glucocorticoids on Leptin Levels in Humans May Be Restricted to Acute Pharmacologic Dosing. (Letter to the Editor) J Clin Endocrinol Metab. 83:1821-1822.

224. Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP. (1998) Corticotropin-Releasing Hormone and Inflammation. Ann NY Acad Sci. 840:21-32.

225. Leung DYM, De Castro M, Szefler SJ, Chrousos GP. (1998) Mechanisms of Glucocorticoid- Resistant Asthma. Ann NY Acad Sci. 840:735-746.

226. Reincke M, Arlt M, Heppner CA, Petzke F, Chrousos GP, Allolio B. (1998) Neuroendocrine Dysfunction in African Trypanosomiasis. Ann NY Acad Sci. 840:809-821.

227. *Chrousos GP, Harris AG. (1998) Hypothalamic-Pituitary-Adrenal Axis Suppression and Inhaled Corticosteroid Therapy. Part I. General Principles. Neuroimmunodulation. 5:277-287.

228. *Chrousos GP, Harris AG, (1998) Hypothalamic-pituitary-adrenal Axis Suppression and Inhaled Corticosteroid Therapy. Part II. Review of the Literature. Neuroimmunodulation. 5:288-308.

229. Orban Z, Bornstein SR, Chrousos GP. (1998) The Interaction Between Leptin and the Hypothalamic-Pituitary- Thyroid Axis. Horm Metab Res. 30:231-235.

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230. Stratakis CA, Chrousos GP. (1998) Adrenal Diseases. In: Principles of Molecular Medicine, L. Jameson (Ed.), Humana Press. Totowa, NJ., p. 495-503.

231. Chrousos GP. (1998) Neuroendocrine Alterations Associated with Altered Sleep, Mood, and Pain Perception. In: The Neuroscience and Endocrinology of Fibromyalgia, S. R. Pillemer (ed.), The Haworth Press, Inc., Binghampton, NY, p. 51-55 and J. Musculoskeletal Pain. 6:51-55, 1998.

232. Diamanti-Kandarakis E, Chrousos GP. (1998) Cushing‟s Syndrome and Androgen Excess. In: Androgen Excess Disorders in Women. R. Azziz, J.E. Nestler, D. Dewailly (eds). Lippincott-Raven Publishers, Philadelphia, p.569-584.

233. Margioris A, Chrousos GP. (1998) Adrenal Disorders. In: Handbook of Clinical Neurology. Part II. Systemic Diseases. Vinten P.J., Bruyn G.W. (Eds.) Elsevier Science. 26:205-220

234. *Gold PW, Chrousos GP. (1999) The Endocrinology of Melancholic and Atypical Depression: Relation to Neurocircuitry and Somatic Consequences. Proc Assn Amer Phys. 111:22-34

235. *Bornstein SR, Chrousos GP. (1999) Adrenocorticotropin ACTH- and Non-ACTH-Mediated Regulation of the Adrenal Cortex: Neural and Immune Inputs. J Clin Endo Metab. 84:1729-1736.

236. Chrousos GP. (2000)The Role of Stress and the Hypothalamic-Pituitary-Adrenal Axis in the Pathogenesis of the Metabolic Syndrome: Neuro-Endocrine and Target Tissue-related Causes (Review). Intern J Obesity. 24:S50-S55

237. Tsigos C, Kyrou I, Papanicolaou D, Chrousos GP. (1998) Prolonged Suppression of Corticosteroid- binding Globulin by Recombinant Human Interleukin-6 in Man. [Letter to the Editor]. J Clin Endo Metab. 83:3379.

238. Masi AT, Chrousos GP, Bornstein SR. (1999) Enigmas of Adrenal Androgen and Glucocorticoid Dissociation in Premenopausal Onset Rheumatoid Arthritis. [Editorial] J Rheumatology. 26:247-250.

239. Torpy DJ, Stratakis CA, Chrousos GP. (1999) Hyper- and Hypoaldosteronism. Vit Horm. 57:177-216.

240. Mastorakos G, Bamberger C, Chrousos GP. (1999) Neuroendocrine Regulation of the Immune Process. In: Plotnikoff N.P., Faith R.F., Murgo A.J., Good R.A., (Eds) Cytokines, Stress and Immunity. CRC Press Boca Raton, Fla., p.17-37.

241. *Bornstein SR, Stratakis CA, Chrousos GP. (1999) Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management. Ann Intern Med. 130:759-771.

242. *Merke DP, Bornstein SR, Braddock D, Chrousos, GP. (1999) Adrenal Lymphocytic Infiltration and Adrenocortical Tumors in a Patient with 21-Hydroxylase Deficiency. (Letter to the Editor) N Engl J Med. 340:1121-1122.

243. Franchimont DP, Chrousos GP. (1999) Glucocorticoid Resistance and Hypersensitivity. Contemporary Endocrinology: Hormone Resistance Syndromes. (Ed. L. Jameson) Humana Press, Totowa N.J., p.259-271

244. Chrousos GP. (1999) Reproductive/placental corticotropin-releasing hormone and its clinical implications, Am. J Obstetrics Gynecol. p.S249-S250.

245. Papanicolaou D, Chrousos GP. Cushing‟s Syndrome (1999) Rakel‟s Current Therapy. Editor Robert E. Rakel. W. B. Saunders Co., Philadelphia p.631-637.

246. Chrousos GP, Gold, PW. (1999) The Inhibited Child “Syndrome”. Thoughts on Its Potential Pathogenesis and Sequelae. In: Extreme Fear, Shyness and Social Phobia: Origins, Biological Mechanisms, and Clinical Outcomes, (eds.) L. A. Schmidt, J. Schulkin, Oxford Univ. Press, New York p.193-200

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247. Koch CA, Bornstein, SR, Pacak K, Chrousos GP. (1998) How does metyrapone decrease seizures? (Letter to the Editor) Neurosurg Rev. 21:302-303.

248. Chrousos GP. (1999) Glucocorticoid Therapy and Withdrawal, Current Practice of Medicine, 1:291- 296

249. *Elenkov IJ, Chrousos GP. (1999) Stress Hormones, Th1/Th2-patterns, Pro/Anti- Inflammatory Cytokines and Susceptibility to Disease. Trends Endo Metab., 10:359-368

250. *Vottero A, Chrousos GP. (1999) Glucocorticoid Receptor Beta: View I. Trends Endo Metab., 10:333-338

251. Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP. (1999) Stress, Corticotropin-Releasing Hormone, Glucocorticoids, and the Immune/Inflammatory Response: Acute and Chronic Effects. Annals NY Academy of Sciences, 876:1-13.

252. Chrousos GP, Elenkov I. (2001) Interactions of the Endocrine and Immune Systems, in DeGroot L., Jameson L. (eds.) Endocrinology 4th Edition, W. B. Saunders Co., Philadelphia, Vol 1, p.571-586.

253. *Bornstein SR, Bottner A, Chrousos GP. (1999) Editorial, Knocking Out the Stress Response. Mol Psychiatry. 4 (5) :403-407.

254. Elenkov I, Wilder R, Chrousos GP, Visi ES. (2000) The Sympathetic Nervous System - an Integrative Interface Between Two “Supersystems”: The Brain and the Immune System. Pharmacol Rev. 52: 595-638

255. *Lafferty AR, Chrousos GP. (1999) Pituitary Tumors in Children and Adolescents, J Clin Endocrinol Metab. 84:4317-4323.

256. *Chrousos GP. (1999) Editorial, A New “New” Syndrome in the New World: Is Multiple Postreceptor Steroid Hormone Resistance Due to a Coregulator Defect? J Clin Endocrinol Metab. 84:4450-4453.

257. Kalantaridou SN, Chrousos GP. (2000) Molecular Defects Causing Ovarian Dysfunction. Ann NY Acad of Sci. Vol. 900, 40-45.

258. Funasaka Y, Sato, H, Chakraborty AK, Ohashi A, Chrousos GP, Ichihashi M. (1999) Expression Proopiomelanocortin, Corticotropin-Releasing Hormone (CRH), and CRH Receptor in Melanoma Cells, Nevus Cells, and Normal Human Melanocytes. J. Investigative Dermatology. 4:105-109

259. Meyer SE, Chrousos GP, Gold PW. (2001) Major Depression and the Stress System. Development and Psychopathology. 13:565-580

260. *Koch CA, Doppman JL, Patronas NJ, Nieman LK, Chrousos GP. (2000) Do Glucocorticoids Cause Spinal Epidural Lipomatosis? – When Endocrinology and Spinal Surgery Meet. Endo Rev. 11:86- 90.

261. Chrousos GP. (2000) Dehydroepiandrosterone and its Sulfate, Electronic Up-Date in Endocrinology, Endocrine Society, US.

262. Negrao AB, Deuster PA, Gold PW, Singh A, Chrousos GP. (2000) Individual Reactivity and Physiology of the Stress Response. Biomed & Pharmacother. 54:122-128.263.

263. Chrousos GP. (2000) The Stress Response and Immune Function: Clinical Implications, The 1999 Novera H. Spector Lecture. Ann New York Acad Sci. 917:38-67.

264. Vottero A, Chrousos GP. (1999) Glucocorticoid Receptor Isoforms Alpha and Beta: Potential Physiological and Pathological Importance. The J of Endocrine Genetics. 1: 61-71.

265. Stratakis CA, Chrousos GP. (1999) Adrenal Cancer, Endocrinology and Metabolism Clinics of North America, 29:15-25. 98

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266. Elenkov IJ, Chrousos GP. (1999) Stress, cytokine patterns and susceptibility to disease. Stress and Immunity: the Neuroendocrine Link, Baillière‟s Clinical Endocrinology and Metabolism. 13(4): 583-595.

267. Willenberg HS, Bornstein SR, Chrousos GP. (2000) Disease, Stress-Induced, Overview, Encyclopedia of Stress, Vol. 1, Academic Press, San Diego. 1:709-713.

268. Willenberg HS, Bornstein SR. Chrousos GP. (2000) Adrenal Insufficiency, Encyclopedia of Stress, Academic Press, San Diego. 1:58-63.

269. Bornstein SR, Stratakis CA, Chrousos GP. (2000) Cushing‟s Syndrome, Medical Aspects, Encyclopedia of Stress, Vol. 1, Academic Press San Diego. 1: 615-621.

270. Koch CA, Bornstein SR, Chrousos GP, Stratakis CA. (2000) Primare pigmentierte nodulare adrenokortikale Dysplasie (PPNAD) in Rahmen des Carney-Komplexes als Ursache eines Cushing-Syndroms. Medizinische Klinik. 95:224-230.

271. Creatsas G, Mastorakos G, Chrousos GP. (2000) Introduction: Setting Reproductive Health Priorities to Meet the Needs of the New Millennium. Ann NY Acad Sci. 900:viii-xv.

272. Vgontzas AN, Papanicolaou DA, Chrousos GP. (2000) Chronic Systemic Inflammation in Overweight and Obese Adults. (Letter to the editor) JAMA. 283(17):2235-2236.

273. Chrousos GP, Margioris AN. (2000) Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung, Basic and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 39:660-678.

274. Chrousos GP, Zoumakis E, Gravanis A. (2000) The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange, McGraw-Hill, New York, New York. 40:679-710.

275. Pacak K, Chrousos GP, Koch CA, Lenders JWM, Eisenhofer G. (2001). “Pheochromocytoma: Progress in Diagnosis, Therapy, and Genetics” in Margioris, A.N. and Chrousos, G.P. (Eds.) Adrenal Disorders, Humana Press: New Jersey, p. 379-414

276. *Leung DYM, Chrousos GP. (2000) Is there a role for glucocorticoid receptor-beta in glucocorticoid- dependent asthmatics? (Editorial) Am J Respir Crit Care Med. 162:1-3.

277. Bornstein SR, Chrousos GP. (2001) Chapter 229.The Hypothalamic-Pituitary-Adrenal Axis in Stress and Critical Illness. Principles and Practice of Endocrinology and Metabolism, K. Becker (Ed.) 3rd Edition, Lippincott Williams & Wilkins Philadelphia, Pa p. 2087-2094

278. Kino T, Vottero A, Chrousos GP. (2001) “Mineralocorticoid and Glucocorticoid Receptors” in Burris, T.P. and McCabe, E.R.B. (Eds.) Nuclear Receptors and Genetic Disease, Academic Press: San Diego, p. 297-307.

279. *Chrousos GP. (2001) Adrenal Suppression and Clinical Glucocorticoid Deficiency in the Premature Infant: No Simple Answers (Clinical Perspective). J Clin Endocrinol Metab.86: 473-474

280. Miller W, Chrousos GP.(2001) Chapter 11: The Adrenal Cortex. Endocrinology and Metabolism, Felig P., and Frohman L. Eds., 4th Edition, McGraw-Hill, New York, NY. p387-524

281. Chrousos GP. (2001) Chapter 14: Glucocorticoid Therapy. Endocrinology and Metabolism, Felig P. and Frohman L., Eds. 4th Edition, McGraw-Hill, New York, NY, p 609-632

282. Chrousos GP. (2000) Stress, Chronic Inflammation, and Emotional and Physical Well-being: Concurrent Effects and Chronic Sequelae. J Allergy Clin Immunol. 106: S275-S291.

283. Elenkov IJ, Chrousos GP, Wilder RL. (2000) Neuroendocrine Regulation of IL-12 and TNF-(/IL-10 Balance. 99

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Ann NY Acad Sciences, 917:94-105.

284. Koch CA, Huang SC, Vortmeyer AO, Zhuang Z, Chrousos GP, Pacak K. (2000) A patient with MEN 2 and multiple mutations of RET in the germline (Letter to the editor). Experimental and Clinical Endocrinology and Diabetes. 108:493.

285. Torpy D, Stratakis CA, Chrousos GP. (2000) Familial Hyperaldosteronism. Braz J Med Biol Res. 33:1149- 1155.

286. Chikanza IC, Petrou P, Chrousos GP. (2000) Perturbations of Arginine Vasopressin Secretion during Inflammatory Stress. Ann New York Acad Sci. 917:825-834.

287. *Merke DP, Bornstein SR, Avila N, Chrousos GP. (2002) Future Directions in the Study and Management of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. Ann Internal Med. 136:320-334

288. Cizza G, Ayala A, Daley M, Gold PW, Chrousos GP. (2001) Depression and Osteoporosis: Association or Causal Relationship? In: Physical Consequences of Depression, Ed. J. H. Thakore, Wrightson Biomedical Publishing LTD, Philadelphia, Penn 107-24.

289. *Kino T, Chrousos GP. (2001) Glucocorticoid and Mineralocorticoid Resistance/Hypersensitivity Syndromes. J. Endocrinol. 169:437-445

290. Chrousos GP, Kino T. (2002) Corticosteroid (Glucocorticoid) Receptor. Encyclopedia of Molecular Medicine, T. Creighton, Editor, John Wiley and Son, New York, N.Y. 916-919

291. Vottero A, Chrousos GP. (2004) Glucocorticoid Resistance and States. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 235-241

292. *Meyer SE, Chrousos GP, Gold PW. (2001) Major Depression and the Stress System: A Lifespan Perspective. Development and Psychopathology. 13: 563-578

293. *Cizza G, Ravn P, Chrousos GP, Gold PW. (2001) Depression: a major, unrecognized risk factor for osteoporosis? Trends Endocrinol Metab. 12(5): 198-203.

294. *Mitsiades N, Poulaki V, Mitsiades CS, Koutras DA, Chrousos GP. (2001) Apoptosis induced by FASL and TRAIL/APO2L in the pathogenesis of thyroid disease. Trends in Endocrinol. Metabolism. 12:384-390

295. Bornstein S, Chrousos GP. (Guest Eds. ). (2001) Adrenals. Reviews in Endocrine and Metabolic Disorders 3; Issue 3.

296. Magiakou MA, Chrousos GP. (2002) Cushing Syndrome in Children and Adolescents: Current Diagnostic and Therapeutic Strategies. J Endocrinol Invest. 25: 181-194

297. McGriff NJ, Csako G, Kabbani M, Diep L, Chrousos GP, Pucino F. (2001) Treatment Options for a Patient Experiencing Pruritic Rush Associated with Transdermal Testosterone. A Review of the Literature. Pharmacotherapy. 21:1425-35

298. Joint LWPES/ESPE CAH Working Group. Consensus Statement on 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 87: 4048-4053

299. Chrousos GP, Ghizzoni L, New MI. (Guest Eds.) (2001) Endocrine Diseases: From Childhood to Adulthood. Special Issue: J Endocrinol Invest. 24 Issue 9

300. Habib K, Gold PW, Chrousos GP. (2001) Neuroendocrinology of Stress. Endocrinol. Metab. Clin. NA 30: 695- 728

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301. *Kino T, Chrousos GP. (2001) Editorial. AIDS-related Insulin Resistance and Lipodystrophy: A Multifactorial Viral and Iatrogenic Condition. Endocrine Practice. 7: 479-484

302. *Koch C, Chrousos G. P. (2001) Editorial. Is the Diminuto/Dwarf1 Gene Involved in Physiologic Adrenocortical Size Regulation and Tumor Formation? J Clin Endocrinol Metab. 86: 5127-9

303. Carter CS, Altemus M, Chrousos GP. (2001) Neuroendocrine and Emotional Changes in the Post-partum Period. Progr Brain Res. 133: 241-249

304. Chrousos GP, Lafferty A. (2001) Glucocorticoid Therapy and Cushing Syndrome. eMedicine Journal 2(9)

305. Chrousos GP, Lafferty A. (2001) Nelson Syndrome. eMedicine Journal 2(9)

306. Chrousos GP, Lafferty A., (2001) Hyperaldosteronism. eMedicine Journal 2(9)

307. Radebold K, Koch CA, Chrousos GP. (2001) Multiple Endocrine Neoplasias. eMedicine Journal 2(9)

308. Koch CA, Pacak K, Chrousos GP. (2002) Chapter 37. Endocrine Tumors. In: Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology; 4th edition, Lippincott Williams & Wilkins; Philadelphia, PA;p 1115-1148

309. Koch CA, Chrousos GP. (2003) Diagnosis and Management of Cushing's Disease. In: Powell M, Lightman SL, Laws ER (eds.): Management of Pituitary Tumors: The Clinician's Practical Guide. Humana Press, Totowa, NJ; p 51-76

310. Koch CA, Huang SC, Vortmeyer AO, Chrousos GP, Pacak K, Zhuang Z. (2001) Do somatic RET mutations represent a phenomenon of tumor progression ? Curr Opin Clin Exp Res. 3(3):140-145

311. *Gold PW, Chrousos GP. (2002) Organization of the Stress System and Its Dysregulation in Melancholic and Atypical Depression: High vs. Low CRH/NE States. Mol. Psychiatry 7: 254-275

312. *Kino T, Chousos GP. (2002) Editorial. Tissue-specific Glucocorticoid Resistance/Hypersensitivity Syndromes: Multifactorial States of Clinical Importance. J Allergy Clin Immunol. 109: 609-613

313. *Koch CA, Chrousos GP, Chandra R, Evangelista R S, Gilbert JC, Nobuhara K, Zhuang Z, Vortmeyer AO. (2002) Two-hit Model for Tumorigenesis of Nevoid Basal Cell Carcinoma (Gorlin) Syndrome-associated Hepatic Mesenchymal Tumor. Am J Med Genetics. 109: 74-76

314. Vgontzas AN, Vela-Bueno A, Chrousos GP. (2002) Chapter 50. Endocrine Disorders and Sleep. In: Sleep Medicine, Lee-Chiong TL, Sateia MJ, Carscadon MA (Eds.) Hanley and Belfus, Inc. Philadelphia p 477-487

315. Habib K, Gold PW, Chrousos G. (2002) Hypothalamic-pituitary-adrenal Axis: Introduction to Physiology and Pathophysiology. Hormones, Brain and Behavior. 4: 841-866

316. *Vgontzas A, Chrousos GP. (2002) Editorial. Sleep Disordered Breathing, Sleepiness, and Insulin Resistance: Is the Latter a Consequence, a Pathogenetic Factor or Both? Sleep Medicine 3: 389-391

317. * Kalantaridou S, Chrousos GP. (2002) Clinical Review 148. Monogenic Disorders of Puberty. J Clin Endocrinol Metab. 87: 2481-2494

318. Chrousos GP. (2002) Chapter 264. Cushing Syndrome and Cushing Disease.In: L. Finberg and R Kleinman, Eds. Saunders Manual of Pediatric Practice 2nd Edition, WB Saunders Co.Philadelphia p909-911

319. Chrousos GP, Linder B. (2002) Chapter 278. Steroid Withdrawal. In: L. Finberg and R Kleinman, Eds. Saunders Manual of Pediatric Practice 2nd Edition, WB Saunders Co. Philadelphia p950-952

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320. *Tsigos C, Chrousos GP. (2002) Hypothalamic-pituitary-adrenal Axis, Neuroendocrine Factors and Stress. Psychosomatic Research. 53: 865-871

321. Gold PW, Gabry KE, Yasuda MR, Chrousos GP. (2002) Divergent Endocrine Abnormalities in Melancholic and Atypical Depression: Clinical and Pathophysiologic Implications. Endocrinol. Metab. Clin. North America 31:37-62

322. Vgontzas AN, Chrousos GP. (2002) Sleep, the Hypothalamic-pituitary-adrenal Axis, and Cytokines: Multiple Interactions and Disturbances in Sleep Disorders. Endocrinol Metab Clin North America. 31: 15-36

323. Koska J, Ksinantova L, Sebokova E, Kvetnansky R, Klimes I, Chrousos G, Pacak K. (2002) Endocrine Regulation of Subcutaneous Fat Metabolism during Cold Exposure in Humans. Ann NY Acad Sci. 967: 500- 505

324. Chrousos GP. (2002) Chapter 1. Organization and Integration of the Endocrine System. In: Pediatric Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14.

325. Elenkov IJ, Chrousos GP. (2002) Stress Hormones, Proinflammatory and Antiinflammatory Cytokines and Autoimmunity. Ann N Y Acad Sci. 966: 290-303.

326. *Grammatopoulos D, Chrousos GP. (2002) Structural and Signalling Diversity of Corticotropin-releasing Hormone (CRH) and Related Peptides and Their Receptors: Potential Clinical Applications of CRH Receptor Antagonists. Trends in Endocrinol Metab. 13: 436-444

327. Kino T, Vottero A, Charmandari E, Chrousos GP. (2002) Familial/Sporadic Glucocorticoid Resistance Syndrome and Hypertension. Ann NY Acad Sci. 970: 101-111

328. Alesci S., Chrousos GP, Pacak K. (2002) Genomic Medicine: Exploring the Basis of a New Approach to Endocrine Hypertension. Ann NY Acad. Sci 970: 177-192

329. Working Group, Lawson Wilkins Pediatric Endocrine Society and European Society for Pediatric Endocrinology (2002) Consensus Statement on Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 87: 4042-4047

330. Vottero A, Chrousos GP. (2002) Glucocorticoid Resistance and Hypersensitivity Syndromes. Oxford Textbook of Endocrinology and Diabetes, Eds. J. Wass and S. Shalet Oxford University Press, Oxford, p. 845-851

331. Chrousos GP. (2002) The Neuroendocrinology of Stress. Clinical Endocrinology (Japan) 51:13-14

332. *Franchimont D, Kino T, Galon J, Meduri GU, Chrousos GP. (2003) Glucocorticoids and Inflammation Revisited. NIH Clinical Staff Conference. NeuroImmunoModulation. 10:247-260

333. *Koch C, Pacak K, Chrousos GP. (2002) The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors. J Clin Endocrinol Metab. 87: 5367-5384

334. Vgontzas A, Chrousos GP. (2003) Hypothalamic-pituitary-adrenal Axis and Sleep. Chapter 31. www.Endotext.com

335. *Charmandari E, Kino T, Souvatzoglou E, Chrousos GP. (2003) Pediatric Stress: Hormonal Mediators and Human Development. Hormone Res. 59: 161-179

336. *Gerrity TR, Bates J, Bell DS, Chrousos G, Furst G, Hedrick T, Hurwitz B, Kula RW, Levine SM, Moore RC, Schondorf R. (2002) Chronic Fatigue Syndrome: What Role Does the Autonomic System Play in the Pathophysiology of this Complex Illness? NeuroImmunoModulation. 10:134-141

337. Makrigiannakis A, Zoumakis E, Kalandaridou S, Mitsiadis N, Margioris N, Chrousos G, Gravanis A. (2002) 102

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Corticotropin-releasing Hormone (CRH) and Immunotolerance of the Fetus. Bioch Pharmacol. 7507: 917-921

338. Chrousos GP. (2002) New Editor-in-Chief‟s Note. NeuroImmunoModulation. 10: 129-131

339. Kino T, Chrousos GP. (2002) The Hypothalamic-pituitary-adrenal Axis in AIDS. www.endotext.com

340. *Masi A, Chrousos GP. (2003) Editorial: Polycystic Ovarian Syndrome and Rheumatoid Arthritis: Possible Clues to Hormonal Influences on Chronic Inflammation. Sem Arthritis and Rheumatism. 33:67-71

341. Magiakou MA, Chrousos GP. (2002) Glucocorticoid Therapy and Adrenal Suppression. www.endotext.com

342. Latronico AC, Chrousos GP. (2002) Adrenal Cancer. Diagnosis and Treatment. www.endotext.com

343. Arai K, Shibasaki T, Chrousos GP. (2002) Aldosterone Deficiency and Resistance. www.endotext.com

344. *Kino T, Mirani M, Alesci S, Chrousos GP. (2003) AIDS-related Lipodystrophy/Insulin Resistance Syndrome. Horm Metab Res. 35: 129-136

345. *Wolak M, Chrousos GP, Gold PW. (2003) Stress System: Emphasis on Corticotropin-releasing Factor in Physiologic Stress Responses and the Endocrinopathies of Melancholic and Atypical Depression. Endocrine Rev., in Press

346. Vottero A, Chrousos GP. (2003) Glucocorticoid Resistance Syndromes and States. Chapter 16. www.Endotext.com

347. Kino T, Chrousos GP. (2003) AIDS-related Insulin Resistance and Lipodystrophy Syndrome. Current Drug Targets- Immune, Endocrine and Metabolic Disorders. 3: 111-117

348. *Hochberg Z., Pacak K., Chrousos GP (2003) Endocrine Withdrawal Syndromes. Endocrine Rev. 24: 523-548

349. Koch C, Chrousos GP. (2003) Chapter 4. Cushing Disease, In: Management of Pituitary Tumors: The Clinician‟s Practical Guide. Eds M P Powell, SL Lightman and Laws ER Humana Press, Totowa NJ, 51-75

350. Charmandari E, Chrousos GP. (2003) Adrenal Insufficiency. www.endotext.com

351. Gourgiotis L, Chrousos GP. (2003) Pseudo-Cushing States. www.endotext.com

352. Charmandari E, Kino T, Chrousos GP. (2003) Glucocorticoids. Neonatal and Pediatric Pharmacology. Second Edition. Ed. S. Yaffe. Lippincott Williams and Wilkins, Philadelphia, Penn. p 713 (14)

353. Pedrone E, Goldman R, Calis K, Chrousos GP, Cizza G. (2003) Glucocorticoid-induced Osteoporosis. www.endotext.com

354. Vgontzas A, Bixler EO, Chrousos GP. (2003) Metabolic Disturbances in Obesity vs. Sleep Apnea: The Importance of Visceral Obesity and Insulin Resistance. J Intern Med. 254: 32-4

355. Arnaldi G, Angeli A, Atkinson A, Bertagna X, Cavagnini F, Chrousos G. Fava A, Findling J, Gaillard RC, Grossman AB, Kola A, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M. (2003) Diagnosis And Complications of Cushing‟s Syndrome: A Consensus Statement Journal of Clinical Endocrinology and Metabolism 88: 5593-602

356. Charmandari E, Kino T, Chrousos GP. (2004) Glucocorticoid Resistance Syndrome. eMedicine.com

357. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A. (2003) Uterine and Embryonic Trophoblast CRH Promotes Implantation and Maintenance of Early Pregnancy. Ann NY Acad Sci. 997: 85-92

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358. Kalantaridou SN, Makrigiannakis A, Mastorakos G, Chrousos GP. (2003) Roles of Reproductive Corticotropin-releasing Hormone. Ann NY Acad Sci, 997: 129-135

359. Kalantaridou SN, Makrigiannakis A, Zoumakis E and Chrousos GP (2004) Reproductive Functions of Corticotropin-releasing Hormone (CRH). Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists) J Reprod Immunol. 51(4): 269-74.

360. Chrousos GP. (2004) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung, Basic and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 641-660

361. Chrousos GP. (2004) Chapter 40. The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange, McGraw- Hill, New York, New York 661-692

362. Kino T, Charmandari E, Chrousos GP. (2003) Glucocorticoid Receptor. www.Endotext .com

363. Kino T, De Martino MU, Charmandari E, Mirani M, Chrousos GP. (2003) Tissue Glucocorticoid Resistance/ Hypersensitivity Syndromes. J Ster Biochem Mol Biol. 85:457-467.

364. Kino T, Charmandari E, and Chrousos GP. (2003) Basic and Clinical Implications of Glucocorticoid Actions. Proceedings of a Conference Dedicated to Professor Yukitaka Miyachi. Horm and Metabol Res. 35: 628-638 pr

365. Kanaka-Gantenbein C, Mastorakos G, Chrousos GP. (2003) Endocrine –related Causes and Consequences of Intrauterine Growth Retardation. Ann NY Acad Sci. 997: 150-157

366. Kino T, and Chrousos GP. (2004) Chapter 14. Glucocorticoid and Mineralocorticoid Receptors and Associated Diseases. Essays in Biochemistry, Vol 40 : The Nuclear Receptor Superfamily. 40:137-55.

367. Baker DG, Geracioti TD, Kasckow JW, Zoumakis E, Chrousos GP. (2003) Chapter 14. Cytokines and Post- traumatic Stress Disorder. In: Cytokines and Mental Health, Ed. Z. Kronfol, Kluwer Academic Publishers, Boston.301-338.

368. Charmandari E, Kino T, Chrousos GP. (2004) Glucocorticoid Receptor.In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA

369. Charmandari E, Chrousos GP. (2004) Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA

370. Charmandari E, Chrousos GP. (2004) Adrenal Insufficiency. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA 75-80

371. Chrousos GP. (2004) Stress and Endocrine Physiology. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA

372. Ayala A, Chrousos GP. (2004) Hypercortisolism and Cushing Syndrome. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA 540-548

373. Grimaldi L, Chrousos GP. Metabolic and Endocrine Disorders. In Nichols D, Yaster M, Lappe DG, Haller JA and Paidas C (eds.) Golden Hour: The Handbook of Advanced Pediatric Life Support. Mosby Pub. Philadelphia (in press).

374. Chrousos G, Charmandari E, and Kino T. (2004) Editorial. Networks of Glucocorticoid Actions: An Introduction to Systems Biology. J Clin Endocrinol Metab. 89: 563-564

375. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A. (2004) Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin. Curr Drug Targets- Imm Endo and Metab Dis. 4:75-78 104

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376. Charmandari E, Kino T, Chrousos GP. (2004) Familial/Sporadic Glucocorticoid Resistance. Orphanet Encyclopedia www.orpha.net

377. Charmandari E, Kino T, Chrousos GP. (2004) Glucocorticoid Actions. Orphanet Encyclopedia www.orpha.net

378. Contoreggi C, Rice KC, Chrousos GP (2004) Non-peptide Corticotropin-releasing Hormone Receptor Type 1 Antagonists and their Applications in Psychosomatic Disorders. Neuroendocrinology. 80:111-123

379. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004) Reproductive Functions of Corticotropin-releasing Hormone. Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists). Am J Reprod Immunol. 51: 269-274

380. Chrousos G. (2004) Editorial. The Glucocorticoid Receptor Gene, Longevity, and the Highly Prevalent Complex Disorders of Western Societies. Am J Medicine. 117: 204-207

381. Chrousos GP. (2004) Editorial. Is 11-beta- Hydroxysteroid Dehydrogenase Type 1 a Good Therapeutic Target for Blockade of Glucocorticoid Actions? Proc Ntl Acad Sci USA, 101: 6329-30

382. Magiakou MA, Chrousos GP. (2004) Adrenal Suppression. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA 81-89

383. Koch C, Chrousos GP. (2004) Adrenal Tumors: Molecular Pathogenesis. In: Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA 90-98

384. Charmandari E, Kino T, Chrousos GP. (2004) Glucocorticoid Receptor. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA 229-234

385. Charmandari E, Chrousos GP. (2004) Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, San Diego, CA, USA 253-259

386. Alesci S, Su YA, Chrousos GP. (2004) hMiDas and hMitChip (2004) New Opportunities in Mitochondrial Bioinformatics and Genomic Medicine. Eds. Long R., Antani S., Lee DJ, Nutter B, Zhang M. Proc 17 IEEE Computer-based Medical Systems, Los Alamitos, Ca p329-334

387. Tsigos C, Kyrou I, Chrousos GP. (2004) Stress, Endocrine Physiology and Pathophysiology. www.Endotext.com

388. Chrousos GP. (2004) Book Review. Male Hypogonadism, by Winters SG, Ed Totowa, NJ: Humana Press. Annals of Intern Medicine. 140: 1064

389. Chrousos GP. (2004) Book Review. Microcompetition with Foreign DNA and the Origin of Chronic Disease, by Polansky H, Ed. Center for Biology of Chronic Disease, Rochester. Neuroimmunomodulation. 11: 278

390. Charmandari E, Kino T, Chrousos G. (2004) Glucocorticoids and their actions: an introduction. Ann N Y Acad Sci. 1024:1-8.

391. Charmandari E, Kino T, Chrousos G. (2004) Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms. Ann N Y Acad Sci. 1024:168-81.

392. Kino T, Chrousos G. (2004) Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? Ann N Y Acad Sci. 1024:153-67.

393. DeMartino MU, Alesci S, Chrousos GP. (2004) Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. Ann N Y Acad Sci. 1024:72-85. 105

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394. Kino T, Chrousos GP. (2004) Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays Biochem. 40:137-155.

395. *Vgontzas AN, Bixler EO, Lin H-M, Prolo P, Trakada G, Chrousos G. (2005) Interleukin-6 and Its Circadian Secretion in Humans. Neuroimmunomodulation. 12(3):131-140

396. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004) Stress and the female reproductive system. J Reprod Immunol. 62:61-8.

397. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G. (2004) Endometrial and placental CRH as regulators of human embryo implantation. J Reprod Immunol. 62:53-9.

398. *Kanaka-Gantenbein C, Fryssira H, Chrousos G, Mastorakos G (2004) Growth hormone deficiency in a case of cerebrofaciothoracic syndrome in one of two affected siblings. Am J Med Genet. 129A:330.

399. Costello RB, Chrousos GP. (2005) Other Bioactive Food Components and Dietary Supplements. Report to the Institute of Medicine, Natl Acad Sci US, pp 462.

400. Charmandari E, Kino T, Chrousos GP. (2004) Chapter 49. Glucocorticoids,.In: Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice. Eds. Yaffe S and Aranda J. Lippincott, Williams and Wilkins Co,Philadelphia Pa 713-726

401. Weiss LM, Bertagna X, Chrousos GP et al. (2004) Adrenal Cortical Carcinoma, In: Tumors of Endocrine Origin, Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU and Eng C IARC Press, Lyon 139-142

402. Sasano H, Young WF, Jr, Chrousos GP et al. (2004) Adrenal Cortical Adenoma , In: Tumors of Endocrine Origin, Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU and Eng C IARC Press, Lyon 143-146

403. *Linos D, Kiriakopoulos AC, Tsakayannis DE, Theodoridou M, Chrousos G .(2004) Laparoscopic excision of bilateral primary adrenal leiomyosarcomas in a 14-year-old girl with acquired immunodeficiency syndrome (AIDS). Surgery. 136(5):1098-100.

404. Tsigos C, Kyrou I, Chrousos GP. (2005) Stress, Endocrine Manifestations and Diseases. Chapter 6. In: Handbook of Stress Medicine and Health. Second Edition, Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 109-129.

405. Vgontzas AN, Bixler EO, Chrousos GP. (2005) Sleep Apnea Is A Manifestation of the Metabolic Syndrome. Sleep Medicine Reviews. 9(3):211-24.

406. *Charmandari E, Chrousos GP, Merke D. (2005) Adrenocorticotropin Hypersecretion and Pituitary Microadenoma Following Bilateral Adrenalectomy in a Patient with Classic 21-Hydroxylase Deficiency. J Pediatr Endocrinol. 18(1):97-101.

407. *Charmandari E, Tsigos C, Chrousos GP. (2005) Neuroendocrinology of Stress. Ann Rev Physiol. Vol. 67: 259-284

408. *Chrousos G, Kino T. (2005) Ikaros Trancription Factors: Flying between Stress and Inflammation. J Clin Invest. 115:844-848

409. *Alesci S, De Martino MU, Ilias I, Gold PW, Chrousos GP. (2005) Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspects. Neuroimmunomodulation. 12(1):1-19.

410. Ayala A, Chrousos G. (2005) Cushing‟s Syndrome. In: Adrenal Glands: Diagnostic Aspects and Surgical 106

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Therapy. Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York p57-66

411. Charmandari E, Chrousos G, Merke D (2005) Classic Congenital Adrenal Hyperplasia. In: Adrenal Glands: Diagnostic Aspects and Surgical Therapy. Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York p101-114

412. Chrousos GP, Makrigiannakis A. (2005) Guest Editors. 39th Annual Meeting of the European Society of Clinical Investigation. Eur J Clin Invest. 35 (Suppl 2): 1-94

413. Kino T, Chrousos G. (2005) Glucocorticoid Effects on Gene Expression. In: Handbook on Stress and the Brain. Vol 15. Eds. Stechler T, Kalin NH and Reul JMHM. p 295- 311

414. Vgontzas AN, Pejovic S, Chrousos GP. (2005) Endocrine and Metabolic Disorders and Sleep. Encyclopedia of Sleep Medicine, Ed. Teofilo Lee-Chiong. John Wiley&Sons, Inc.

415. Siragy HM, Chrousos GP, Shupnik MA. (2005) Chapter 33. Glucocorticoids and Mineralocorticoids.In: Brody‟s Clinical Pharmacology. Molecular to Clinical. 4th Edition. Eds: KP Minneman, L Wecker. Elsevier- Mosby p 409-421

416. *Chrousos GP, Kino T. (2005) Interactive Functional Specificity of the Stress and Immune Responses: The Ying, the Yang and the Defense Against Two Major Classes of Bacteria. J Infectious Dis. 192: 551-555

417. Vgontzas AN, Bixler EO, Chrousos GP. (2005) Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev. 9(3):211-24.

418. Magiakou MA, Chrousos GP. (2005) Chapter 4.Biological Basis of Stress-related Diseases. In: Research Companion to Organizational Health Psychology. Eds. AS Antoniou and CL Cooper. EE Publishing, Cheltenham UK p70-86

419. *Papadimitriou A, Chrousos GP. (2005) Reconsidering the Sex Diffrences in the Incidence of Pubertal Disorders. Horm Metab Res. 37:708-710

420. Chrousos GP, Kino T. (2005) Glucocorticoid Action Networks and Systemic Complex Diseases. In: Hormones, Age and Cancer. Berstein L (ed) Nauka Publ Co. St. Petersburg p.226-236

421. Stratakis C and Chrousos GP (2005) Hypothalamic Hormones, In: Endocrinology: Basic and Clinical Principles, Second Edition, Eds. S Melmed and PM Conn. Humana Press, Totowa NJ , p.173-195

422. *Meduri GU, Chrousos GP. (2006) Effectiveness of Prolonged Glucocorticoid Treatment in ARDS: The Right Drug the Right Way? Crit Care Med. 34(1):236-238

423. *Chrousos GP, Kino T. (2005) Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic. Perspective, Science: Signal Transduction Knowledge Environment (STKE). 304: pe48

424. *Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP. (2005) Cytokine Dysregulation, Inflammation and Well-being. Neuroimmunomodulation. 12:255-269

425. *Chrousos GP, Kaltsas G. (2005) How Accurate Are Currently Used Methods of Determining Glycemia in Critically Ill Patients and Do They Affect Their Clinical Course? Crit Care Med. 33:2849-51

426. *Chrousos GP, Kaltsas G. (2005) Post-SARS Sickness Syndrome Manifestations and Endocrinopathy: how, why, and so what? Clin Endocrinol (Oxf). 63(4):363-5.

427. *Macrigiannakis A, Kalantaridou S, Minas V, Nikas G, Chrousos GP. (2006) Hormonal and Cytokine Regulation of Early Implantation. Trends Endocrinol Metab. 17(3):101-9

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428. *Kalantaridou SN, Naka KK, Bechlioulis A, Makrigiannakis A, Michalis L, Chrousos GP. (2006) Premature Ovarian Failure, Endothelial Dysfunction and Estrogen/Progestogen Replacement. Trends Endocrinol Metab. 17(5):178-85.

429. *Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2007) Peripheral Corticotropin-releasing Hormone Is Produced in the Immune and Reproductive Systems: Actions, Potential Roles and Clinical Implications. Front Bioscience. 12:572-80

430. *Pervanidou P, Kanaka-Gantenbein C, Chrousos GP. (2006) Assessment of Metabolic Profile in a Clinical Setting. Curr Opinion in Clinical Nutrition and Metabolic Care. 9(5):589-595

431. Zoumakis E, Grammatopoulos D, Chrousos G. (2006) Corticotropin-releasing Hormone Antagonists. Eur J Endocrinol. 155 (Suppl1) S85-S90

432. Chrousos GP , Kaltsas GA. (2006) Chapter 16. The Stress System and the Hypothalamic-pituitary-adrenal Axis in Rheumatoid Arthritis. In: Rheumatoid Arthritis, 2nd edition, Firestein GS, Panayi GS, and Wollstein FA. Oxford University Press p221-228

433. Magiakou MA, Smyrnaki P, Chrousos GP. (2006) Hypertension in Cushing's syndrome. Best Pract Res Clin Endocrinol Metab. 20:467-82

434. Kino T, Chrousos GP. (2005) Steroid Hormone Receptor Defects, Molecular Basis.Encyclopedic Reference of Genomics and Proteomics. Springer-Verlag p 1802-1807 On line www.springerlink.com

435. *Giannoulia-Karantana A, Vlachou A, Polychronopoulou S, Papassotiriou I, Chrousos GP. (2006) Melatonin and Immunomodulation: Connections and Potential Clinical Applications: Neuroimmunomodulation. 13(3):63- 74

436. Charmandari E, Chrousos GP. (2006) Metabolic Syndrome Manifestations in Classic Congenital Adrenal Hyperplasia: Do they Predispose to Cardiovascular Atherosclerotic Disease and Secondary Polycystic Ovary Syndrome? Ann NYAcad Sci. 1083: 37-53

437. *Kalantaridou S, Makrigiannakis A, Zoumakis E, Chrousos GP. (2007) Peripheral Corticotropin-releasing Hormone Is Produced in the Immune and Reproductive Systems: Actions, Potential roles and Clinical Implications. Front Biosci. 12:572-80.

438. *Kanaka-Gantenbein C, Fryssira H, Kakavakis K, Bouzas E, Thomaidis L, Chrousos G, Mastorakos G. (2006) Two years of growth hormone treatment in the first growth hormone deficient patient with cerebrofaciothoracic dysplasia. J Pediatr Endocrinol Metab. 19:1179-83.

439. *Chrousos GP. (2007) Commentary: Is laparoscopic adrenalectomy good for all adrenal masses? Nature Clinical Practice: Endocrinology and Metabolism. 3: 210-211

440. Vgontzas AN, Bixler EO, Chrousos GP. (2006) Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann NY Acad Sci. 1083:329-44.

441. Zoumakis E, Rice KC, Gold PW, Chrousos GP. (2006) Potential uses of corticotropin-releasing hormone antagonists. Ann NY Acad Sci.1083: 239-51.

442. Kyrou I, Chrousos GP, Tsigos C. (2006) Stress, visceral obesity, and metabolic complications. Ann N Y Acad Sci.1083: 77-110.

443. *Kino T, Chrousos GP (2007) Virus-mediated Modulation of the Host Endocrine Signaling Systems: Clinical Implications. Trends Endocrinol Metab. 18: 159-166

444. Creatsas G, Mastorakos, Chrousos GP. (2006) Foreword: Women's Health: The World's Safeguard. Ann NY 108

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Acad Sci 1092: xiii–xv.

445. Elenkov IJ, Chrousos GP. (2006) Stress system - organization, physiology and immunoregulation. Neuroimmunomodulation. 13 (5-6):257-67. Epub 2007

446. Kaltsas G, Chrousos GP. (2007) The Neuroendocrinology of Stress. In: Handbook of Psychophysiology Eds. Cacioppo J, Tassinary, and Berntson GG, Cambridge University Press, Cambridge p 303-318

447. *Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM, Chrousos GP. (2007) Mitochondria as Critical Components of the Stress Response. Trends Endocrinol Metab. 18(5):190-8

448. *Kanaka-Gantenbein C, Papandreou E, Stefanaki K, Fryssira H, Kolialexi A, Sophocleous C, Mavrou A, Kitsiou-Tzeli S, Chrousos GP. (2007) Spontaneous Ovulation in a True Hermaphrodite with Normal Male Phenotype and a Rare 46,XX/47,XXY Klinefelter's Mosaic Karyotype. Horm Res. 26; 68 (3):139-144

449. Willenberg HS, Bornstein SR, Chrousos GP. (2007) Adrenal Insufficiency, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 47-52

450. Pervanidou P, Chrousos GP. (2007) Brain Natriuretic Peptide (BNP), In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol 1, p 357-360

451. Chrousos GP, Kaltsas G. (2007) Cardiovascular Disease, Stress In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 410-416

452. Bornstein SR, Gruber M, Willenberg HS, Stratakis CA, Chrousos GP. (2007) Cushing‟s Syndrome, Medical Aspects, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 682-688

453. Willenberg HS, Bornstein SR, Chrousos GP. (2007) Disease, Stress Induced, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 824-828

454. Makrigiannakis A, Petsas G, Chrousos GP. (2007) Eclampsia and Pre-Eclampsia, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 880-884

455. Kalantaridou SN, Vrekoussis T, Makrigiannakis A, Chrousos GP. (2007) Endometriosis, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego,Vol. 1, p 927-931

456. Eleftheriades M, Pervanidou P, Chrousos GP. (2007) Fetal Stress, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 46-51

457. Alevizaki M, Chrousos GP. (2007) Heart Failure, Stress Effects, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 272-274

458. Manoli I, Alesci S, Chrousos GP. (2007) Mitochondria, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 754-761

459. *Makras P, Alexandraki KI, Chrousos GP, Grossman AB, Kaltsas GA. (2007) Endocrine Manifestations in Langerhans‟ Cell Histiocytosis (LCH). Trends Endocrinol Metab 18(6):252-7.

460. *Chrousos GP, Kino T. (2007) Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 10:213-219

461. Kalantaridou SN, Zoumakis E, Makrigiannakis A, Godoy H, Chrousos GP. (2007) Role of Corticotropin- releasing Hormone in Blastocyst Implantation and Early Fetal Immunotolerance. Horm Metab Res. 39:474- 477.

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462. Pervanidou P, Chrousos GP. (2007) Post-traumatic Stress Disorder in Children and Adolescents: From Sigmund Freud's "Trauma" to Psychopathology and the (Dys)metabolic Syndrome. Horm Metab Res. 39:413- 419

463. *Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen, Bokhari F, Zaloga G, Annane D. (2008) Steroid Treatment in ARDS: a Critical Appraisal of the ARDS Network Trial and the Recent Literature. Crit Care Med. 34:61-69

464. Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. (2007) Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metab. 18(7):280-5

465. Chrousos GP. (2007) Organization and Integration of the Endocrine System. The Sleep and Wakefulness Perspective. Sleep Medicine Clinics. 2:125-145

466. Trakada G, Chrousos GP, Pejovic S, Vgontzas AN. (2007) Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity. Sleep Med Clin. 2:251–261

467. Basta M, Chrousos G, Vela-Bueno A, Vgontzas AN. (2007) Chronic Insomnia and the Stress System. Sleep Med Clin. 2:279–291

468. Zoumakis E, Kalantaridou SN, Chrousos GP. (2007) The “Brain-Skin Connection”: Nerve Growth Factor- dependent Pathways for Stress-Induced Skin Disorders. J Mol Med. 85(12):1347-9

469. Cutolo M, Straub R, Chrousos GP, Eds. (2006) Issue on Stress and Autoimmunity. Neuroimmunomodulation. 13: 253-382

470. *Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP. (2007) The Hypothalamic-pituitary-adrenal axis in asthmatic children. Trends Endocrinol Metab. 19:32-38

471. Stefanaki C, Chrousos GP, Katsambas A. (2007) Glucocorticoid and sex hormone receptors: clinical implications and therapeutic relevance. Dermatol Clin. 25(4): 503-13.

472. Kalantaridou SN, Zoumakis E, Weil S, Lavasidis LG, Chrousos GP, Makrigiannakis A. (2007) Reproductive corticotropin releasing hormone, implantation, and fetal immunotolerance. Crit Rev Clin Lab Sci. 44: 461-81.

473. *Marik PE, Pastores SM, Annane D, Meduri GU, Arlt W, Sprung CL, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis T, Singer M, MD; Chrousos GP, Zaloga G, Bokhari F, Vogeser M. (2007) Clinical practice guidelines for the diagnosis and management of corticosteroid insufficiency in critical illness: Recommendations of an international task forc. Critical Care Medicine (Epublication ahead of print)

474. *Charmandari E, Kino T, Ichijo T, Chrousos GP. (2008) Generalized Glucocorticoid Resistance: Clinical Aspects, Molecular Mechanisms and Implications of a Rare Genetic Disorder. J Clin Endocrinol Metab. 93(5):1563-1572

475. Charmandari E, Kino T, Chrousos GP. (2008) Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms. Chapter 5. In: Overcoming Steroid Insensitivity in Respiratory Disease. Eds. Adcock AM and Chung KF. J. Wiley Publ. Chichester, England p73-85

476. Franchimont DP, Chrousos GP. (2008) Glucocorticoid Resistance in Inflammatory Diseases. In Neuroimmune Biology Vol 7. The Hypothalamus-Pituitary-Adrenal Axis. Eds. del Rey A, Chrousos G and Besedovsky, Elsevier Co., Oxford UK p349- 358`

477. Zapanti E, Terzidis K, Chrousos G. (2008) Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in HIV infection and disease. Hormones (Athens). 3:205-216

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478. Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP. (2008) Testing for hypothalamic-pituitary-adrenal axis suppression in asthmatic children. Pediatr Allergy Immunol. 19:466-7; author reply 468-70.

479. Vgontzas AN, Bixler EO, Chrousos GP, Pejovic S. (2008) Obesity and sleep disturbances: Meaningful sub- typing of obesity. Arch Physiol Biochem. 114(4): 224-36

480. Priftis K N, Papadimitriou A, Nicolaidou P, Chrousos GP. (2009) Dysregulation of the Stress Response in Asthatic Children. Allergy 64: 18-31

481. Chrousos GP, Kino T, Charmandari E. (2008) Generalised Glucocorticoid Resistance. European Endocrinology. 4: 93-99

482. *Chrousos GP. (2009) Stress and Disorders of the Stress System. Nature Endocrinology Reviews. 5(7): 374-8

483. *Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM. (2009) Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009 Apr; 123(4):e752-62.

484. Magiakou MA, Sarafoglou K, Stratakis C, Chrousos GP. (2008) Chapter 28. Cushing Syndrome in Children and Adolescents. In Sarafoglou K, Hoffmann GF and Roth KS. (Eds) Pediatric Endocrinology and Inborn Errors of Metabolism. McGraw Hill Co, New York p 411-418

485. Gantenbein-Kanaka C, Chrousos GP. (2008) Sudden Death in Adrenal Disease. Highlights 16: 9-12

486. Priftis KN, Chrousos GP. (2009) Neuroimmunomodulation in asthma: focus on the hypothalamic-pituitary- adrenal axis. Introduction. Neuroimmunomodulation. 16(5): 263-4.

487. Priftis KN, Papadimitriou A, Anthracopoulos MB, Fretzayas A, Chrousos GP. (2009) Endocrine-immune interactions in adrenal function of asthmatic children on inhaled corticosteroids. Neuroimmunomodulation. 16(5): 333-9.

488. Chrousos GP, Kino T, Charmandari E. (2009) Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence. Neuroimmunomodulation. 16(5): 272-83.

489. Pervanidou P, Kolaitis G and Chrousos GP. (2009) Bio-Behavioral Consequences of Traumatic Stress in Childhood and Adolescence: The Effects of War on Children‟s Mental Health, Growth and Development. In: War and Suicide, Sher L and Vilens A. (Eds.), Nova Science Publ. Inc. in press.

490. *Kino T, Su YA, Chrousos GP. (2009) Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology. Mol Life Sci. (ePublcation ahead of print)

491. Chrousos GP, Kino T. (2009) Glucocorticoid Signaling in the Cell: Expanding Clinical Implications to Complex Human Behavioral and Somatic Disorders In: Glucocorticoids and Mood: Clinical Manifestations, Risk Factors, and Molecular Mechanisms. Proc NY Acad Sci. 1179: 153-166

492. Chrousos GP. (2009) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Eds. B. Katzung, SB Masters and AJ Trevor, Basic and Clinical Pharmacology, 11th Edition, Lange, McGraw-Hill, New York, New York. 681-697

493. Chrousos GP. (2009) Chapter 40. The Gonadal Hormones and Inhibitors. Eds. B. Katzung, SB Masters and AJ Trevor, Basic and Clinical Pharmacology, 11th Edition, Lange, McGraw-Hill, New York, New York 699- 726

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494. *Charmandari E, Chrousos GP, Kino T. (2009) Identification of Natural Human Glucocorticoid Receptor (hGR) Mutations or Polymorphisms and their Functional Consequences at the Hormone-Receptor Interaction Level. Methods Mol Biol. 590: 33-60

495. *Meduri GU, Annane D, Chrousos GP, Marik PE, Sinclair SE. (2009) Activation and Regulation of Systemic Inflammation in ARDS: Rationale For Prolonged Glucocorticoid Therapy. Chest. 136 (6):1631-43. Epub 2009 Oct 3. Review

496. *Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E. (2010) The Human Glucocorticoid Receptor: Molecular Basis of Biologic Function. Steroids. 75(1): 1-12.

497. *Zoumakis E, Chrousos GP. (2010) Corticotropin-Releasing Hormone Receptor Antagonists: An Update. Endocr Dev. 17: 36-43. Epub 2009 Nov 24

498. Chrousos G. (2009) Health and Climate Change. International Conference: Climate Change and Challenges for the Future Generations. June 2-3, 2009, Athens, Greece. Livanis Publications Athens, Greece p 102-111.

499. Kino T, Chrousos GP. (2009) Tumor-associated, Estrogen Receptor-related Antigen EBAG9 as a Potential Link between Intracellular Vesicle Trafficking, Immune Homeostasis and Malignancy. Mol Interv. 9: 294-298

500. *Nader N, Chrousos GP, Kino T. (2010) Interactions of the Circadian CLOCK System and the HPA Axis. Trends Endocrinol Metab

501. *Kino T, James H. Segars JH, Chrousos GP. (2010) The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology. Exp Rev Endocrinol Metab. 5: 603-614

502. Tsara V, Amfilochiou A, Papagrigorakis JM, Georgopoulos D, Liolios E, Kadiths A, Koudoumnakis E, Aulonitou E, Emporiadou M, Tsakanikos M, Chatzis A, Choulakis M, Chrousos G. (2010) Guidelines for Diagnosing and Treating Sleep related Breathing Disorders in Adults and Children (Part 3: Obstructive Sleep Apnea in Children, Diagnosis and Treatment). Hippokratia. 14(1): 57-62.

503. *Kaltsas G, Vgontzas A, Chrousos GP. (2010) Fatigue, Endocrinopathies and Metabolic Disorders. PM &R 2:393-398

504. Kanaka-Gantenbein C, Sakka S, Chrousos GP. (2010) Assisted Reproduction and Its Neuroendocrine Impact on the Offspring. Prog Brain Res. 182C: 161-174

505. Pervanidou P, Chrousos GP. (2010) Neuroendocrinology of Post-Traumatic Stress Disorder. Prog Brain Res. 182C: 149-160

506. *Papadimitriou A, Nicolaidou P, Fretzayas A, Chrousos GP. (2010) Constitutional Advancement of Growth, a.k.a. Early Growth Acceleration, Predicts Early Puberty and Childhood Obesity. J Clin Endocrinol Metab. 2010 Jul 7. [Epub ahead of print]

507. *Chrousos GP. (2010) Perspective: Stress and Sex versus Immunity and Inflammation. Science Sign. 3, pe36

508. Vrekoussis T, Kalantaridou SN, Mastorakos G, Zoumakis E, Makrigiannakis A, Syrrou M, Lavasidis LG, Relakis K, Chrousos GP. (2010) The role of stress in female reproduction and pregnancy: an update. Ann N Y Acad Sci. 1205(1):69-75. doi: 10.1111/j.1749-6632.2010.05686.x.

509. *Bacopoulou F, Greydanus DE, Chrousos GP. (2010) Reproductive and Contraceptive Issues in Chronically Ill Adolescents. Eur J Contracept Reprod Health Care. 15(6):389-404.

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510. *Kino T, Chrousos GP. Acetylation-mediated Epigenetic Regulation of Glucocorticoid Receptor Activity: Circadian Rhythm-associated Alterations of Glucocorticoid Actions in Target Tissues. Mol Cell Endocrinol. 2010 Dec 9. [Epub ahead of print]

511. *Kino T, Chrousos GP. (2011) Circadian CLOCK-Mediated Regulation of Target-Tissue Sensitivity to Glucocorticoids: Implications for Cardiometabolic Diseases. Endocr Dev. 20:116-26. Epub 2010 Dec 16

512. Chrousos G. (2011) Q&A: Primary Generalized Glucocorticoid Resistance. BMC Med 9:27

513. *Kassi E, Pervanidou P, Kaltsas G, Chrousos G. (2011) Metabolic Syndrome: Definitions and Controversies. BMC Med. 9(1): 48. [Epub ahead of print]

514. Pervanidou P, Chrousos GP. (2011) Stress and Behavior: The Role of Nutrients with Emphasis on Omega- 3 Fatty Acids. Simopoulos AP (ed): Healthy Agriculture, Healthy Nutrition, Healthy People. World Rev Nutr Diet. Basel, Karger, 2011, vol 102, pp 44–52

515. *Malakasioti G, Gourgoulianis K, Chrousos G, Kaditis A. (2011) Interactions of obstructive sleep-disordered breathing with recurrent wheezing or asthma and their effects on sleep quality. Pediatr Pulmonol. 2011 Aug 1. doi: 10.1002/ppul.21497. [Epub ahead of print]

516. Pervanidou P, Chrousos GP. (2011) Stress and obesity/metabolic syndrome in childhood and adolescence. Int J Pediatr Obes. Suppl 1:21-8.

517. Pervanidou P, Chrousos GP (2011) Emotional/ Behavioral Disorders and Obesity in Childhood: A Clinician‟s Perspective. The European Health Psychologist. 13: 48-51

518. Kino T, Charmandari E, Chrousos GP. (2011) Glucocorticoid receptor: implications for rheumatic diseases. Clin Exp Rheumatol. 29 (Suppl. 68): S32-S41.

519. Tsitsami E, Dermentzoglou V, Moschovi M, Chrousos GP. (2011) Chronic Recurrent Multifocal Osteomyelitis with Concomitant Features of Juvenile Idiopathic Arthritis. Case Rep Rheumatol. 2011:210795. doi: 10.1155/2011/210795. Epub 2011 Dec 29.

520. Halberg F, Cornélissen G, Czaplicki J, Schwartzkopff O, Sanchez de la Pena S, Finley J, Thomas F, Kino T, Chrousos G. (2011) Coexisting wrestling lunisolar periods in a selenosensitive circulation rather than circadian free-running? Leibniz Online 09/2011 Zeitschrift der Leibniz-Sozietät e. V. ISSN#1863-3285 http://www.leibniz-sozietaet.de/journal/archive/09_10/Halberg_et_al.pdf

521. Chrousos GP, Kalantaridou SN, Margioris AN, Gravanis A. (2012) The “Self-plagiarism” Oxymoron: Can One Steal from Oneself? Eur J Clin Invest. 42(3):231-2. doi: 10.1111/j.1365-2362.2012.02645.x. Epub 2012 Jan 24.

522. Kino T, Charmandari E, Chrousos GP. (2012) Disorders of the Hypothalamic-Pituitary-Adrenocortical System. In: Fink G, Pfaff DW, Levine JE, eds. Handbook of Neuroendocrinology. London, Waltham, San Diego: Academic press, Elsevier; 639-658. ISBN: 9780123750976

523. Pervanidou P, Chrousos GP. (2012) Metabolic consequences of stress during childhood and adolescence. Metabolism. 61(5):611-9. doi: 10.1016/j.metabol.2011.10.005. Epub 2011 Dec 5.

524. Chrousos GP. (2012) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Eds. B. Katzung, SB Masters, and AJ Trevor, Basic and Clinical Pharmacology, 12th Edition, Lange, McGraw-Hill, New York, New York. 697-713

525. Chrousos GP. (2012) Chapter 40. The Gonadal Hormones and Inhibitors. Eds. B. Katzung, SB Masters and AJ Trevor, Basic and Clinical Pharmacology, 12th Edition, Lange, McGraw-Hill, New York, New York 715-741

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526. Chrousos GP. (2012) Stress in Early Life: A Developmental and Evolutionary Perspective. In: Z. Hochberg. Evo-Devo of Child Growth. Wiley-Blackwell Co, Hoboken, NJ. p 29-40

527. Kaltsas G, Zannas AS, Chrousos GP. (2012) Chapter 5. Hypothalamic–Pituitary–Adrenal Axis and Cardiovascular Disease in P. Hjemdahl et al. (eds.), Stress and Cardiovascular Disease, DOI 10.1007/978-1- 84882-419-5_5, © Springer-Verlag, London Ltd. p 71-87

528. Kino T, Charmandari E, Chrousos GP. (2012) Chapter 29. Disorders of the Hypothalamic-Pituitary- Adrenocortical System. In: Fink G, Pfaff DW, Levine JE, eds. Handbook of Neuroendocrinology. London, Waltham, San Diego: Academic Press, Elsevier; 2012:639-658. ISBN: 9780123750976, p 640-654

529. Chrousos GP, Kalantaridou SN, Margioris AN, Gravanis A. (2012) The “Self-plagiarism” Oxymoron: Can One Steal from Oneself? Authors Reply. Eur J Clin Invest. doi: 10.1111/j.1365-2362.2012.02664.x. [Epub ahead of print]

530. Mischak H, Ioannidis JP, Argiles A, Attwood TK, Bongcam-Rudloff E, Broenstrup M, Charonis A, Chrousos GP, Delles C, Dominiczak A, Dylag T, Ehrich J, Egido J, Findeisen P, Jankowski J, Johnson RW, Julien BA, Lankisch T, Leung HY, Maahs D, Magni F, Manns MP, Manolis E, Mayer G, Navis G, Novak J, Ortiz A, Persson F, Peter K, Riese HH, Rossing P, Sattar N, Spasovski G, Thongboonkerd V, Vanholder R, Schanstra JP, Vlahou A. (2012) Implementation of proteomic biomarkers: making it work. Eur J Clin Invest. 2012 Mar 27. doi: 10.1111/j.1365-2362.2012.02674.x. [Epub ahead of print]

531. Kaltsas G, Chrisoulidou A, Piaditis G, Kassi E, Chrousos G. (2012) Current status and controversies in adrenal incidentalomas. Trends Endocrinol Metab. 23(12):602-9. doi: 10.1016/j.tem.2012.09.001. Epub 2012 Oct 5.

532. Pervanidou P, Chrousos GP. (2012) Posttraumatic Stress Disorder in Children and Adolescents: Neuroendocrine Perspectives. Sci Signal. 5(245):pt6. doi: 10.1126/scisignal.2003327.

533. Charmandari E, Achermann JC, Carel JC, Soder O, Chrousos GP. (2012) Stress response and child health. Sci Signal. 5(248):mr1. doi: 10.1126/scisignal.2003595.

534. *Kassi EN, Chrousos GP. (2012) The central CLOCK system and the stress axis in health and disease. Hormones (Athens). 12(2):172-91.

535. Charmandari E, Kino T, Chrousos GP. (2013) Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity. Endocr Dev. 24:67-85. doi: 10.1159/000342505. Epub 2013 Feb 1.

536. Contoreggi C, Lee MR, Chrousos G. (2013) Addiction and corticotropin-releasing hormone type 1 receptor antagonist medications. Ann NY Acad Sci. 1282:107-18. doi: 10.1111/nyas.12007. Epub 2013 Feb 11.

537. Tsiouli E, Alexopoulos EC, Stefanaki C, Darviri C, Chrousos GP. (2013) Effects of diabetes-related family stress on glycemic control in young patients with type 1 diabetes: Systematic review. Can Fam Physician. 59(2):143-9.

538. *Hatziavramidis DT, Karatzas TM, Chrousos GP. (2013) Pancreatic Islet Cell Transplantation: An Update. Ann Biomed Eng. 41(3): 469-476. Epub 2012 Oct 16.

539. *Gold PW, Chrousos GP. (2013) Melancholic and atypical subtypes of depression represent distinct pathophysiological entities: CRH, neural circuits, and the diathesis for anxiety and depression. Mol Psychiatry. 18(6):632-4. doi: 10.1038/mp.2013.5.

540. Kassi EN, Kaltsas G, Chrousos GP. (2013) Stress, Trauma and the Impact on the Pituitary. The Hormone Factor in Mental Health: Bridging the Mind-Body Gap. Ed. L. Rio Jessica Kingsley publ, London p: 79-103

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541. Moschonis G, Mougios V, Lionis C, Chrousos GP, Manios Y. (2014) Response to the Letter to the Editor: We're not ready to encourage children to be "Lean" rather than "Fit" Nutr Metab Cardiovasc Dis. 2013 Oct 11. pii: S0939 4753(13)00186-5. doi: 10.1016/j.numecd.2013.08.003.

542. Bacopoulou F, Chrousos G. (2013) Health Risk Behaviors and Resilience in Adolescents. In: Education, Family and Child and Adolescent Health, eds. Antoniou AS and Kirkaldy BD, Diadrassi pubs. Athens, Greece p141-154

543. Charmandari E, Nicolaides NC, Chrousos GP. (2014) Adrenal insufficiency. Lancet. 383(9935):2152-67. doi: 10.1016/S0140-6736(13)61684-0. Epub 2014 Feb 4.

544. Nicolaides NC, Charmandari E, Chrousos GP, Kino T. (2014) Circadian endocrine rhythms: the hypothalamic- pituitary-adrenal axis and its actions. Ann N Y Acad Sci. 1318(1):71-80. doi: 10.1111/nyas.12464.

545. Vlahopoulos S, Critselis E, Voutsas IF, Perez SA, Moschovi M, Baxevanis CN, Chrousos GP. (2014) New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy. Curr Drug Targets. 2014 Jul 14. [Epub ahead of print] PMID:25023646 [PubMed - as supplied by publisher]

546. Chrousos G Video Q & A. The impact of stress. An interview with George Chrousos. BMC Med. 2014 Jun 20; 12:102. doi: 10.1186/1741-7015-12-102.

547. *Nicolaides NC, Charmandari E, Chrousos GP, Kino T. (2014) Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor. BMC Endocr Disord. 2014 Aug 25; 14(1): 71.

548. Chrousos GP (2014) Empathy, Stress and Compassion: Resonance between the Caring and the Cared. In: Shea S, Wynyard R and Lionis C (Eds.) Providing Compassioned Health Care: Challenges in Policy and Practice. Routledge, London and New York, p 35-39

549. Chrousos GP, Zapanti ED. (2014) Hypothalamic-Pituitary-Adrenal Axis in HIV Infection and Disease. Endocrinol Metab Clin North Am. 43(3):791-806. doi: 10.1016/j.ecl.2014.06.002.

550. Kratimenos P, Koutroulis I, Marconi D, Syriopoulou V, Delivoria-Papadopoulos M, Chrousos GP, Theocharis S. (2014) Multi-targeted molecular therapeutic approach in aggressive neuroblastoma: the effect of Focal Adhesion Kinase-Src-Paxillin system. Expert Opin Ther Targets. 18(12):1395-406. doi: 10.1517/14728222.2014.952280. Epub 2014 Sep 5.

551. Nicolaides NC, Kyratzi E, Lamprokostopoulou A, Chrousos GP, Charmandari E. (2014) Stress, the Stress System and the Role of Glucocorticoids. Neuroimmunomodulation. 22(1-2):6-19.

552. Cutolo M, Chrousos GP, Pincus T. (2014) Special Issue on Glucocorticoid Therapy in Rheumatic Diseases: Introduction. Neuroimmunomodulation. 22(1-2):3-5. [Epub ahead of print] No abstract available.

553. Moris DN, Kontos MI, Mantonakis EI, Athanasiou AK, Spartalis ED, Bakoyiannis CN, Chrousos GP, Georgopoulos SE. (2014) Concept of the aortic aneurysm repair-related surgical stress: a review of the literature. Int J Clin Exp Med. 7(9):2402-12. eCollection 2014. Review.

554. Chrousos GP. (2015) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Eds. B. Katzung, SB Masters, and AJ Trevor, Basic and Clinical Pharmacology, 13th Edition, Lange, McGraw-Hill, New York, New York. 680-695

555. Chrousos GP. (2015) Chapter 40. The Gonadal Hormones and Inhibitors. Eds. B. Katzung, SB Masters and AJ Trevor, Basic and Clinical Pharmacology, 13th Edition, Lange, McGraw-Hill, New York, New York 696-722

556. Moschonis G, Tsoutsoulopoulou K, Efstathopoulou E, Tsirigoti L, Lambrinou CP, Georgiou A, Filippou C, Lidoriki I, Reppas K, Androutsos O, Lionis C, Chrousos GP, Manios Y. (2015) Conceptual framework of a 115

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simplified multi-dimensional model presenting the environmental and personal determinants of cardiometabolic risk behaviors in childhood. Expert Rev Cardiovasc Ther. 13(6):673-92. doi: 10.1586/14779072.2015.1039992. Epub 2015 Apr 30.

557. Chrousos GP. (2015) Chapter 99. Glucocorticoid Action-Physiology. Endocrinology-Adult and Pediatric, Eds. L. Jameson, L. De Groot, Elsevier Pub. Co, NewYork 1727-1740

558. Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. (2015) Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment. Cytokine Growth Factor Rev. 26(4):389-403. doi: 10.1016/j.cytogfr.2015.06.001. Epub 2015 Jun 20.

559. Manousopoulou A, Al-Daghri NM, Garbis SD, Chrousos GP. (2015) Vitamin D and cardiovascular risk among adults with obesity: a systematic review and meta-analysis. Eur J Clin Invest. 45(10):1113-26. doi: 10.1111/eci.12510. Epub 2015 Sep 3.

560. Poser SW, Chenoweth JG, Colantuoni C, Masjkur J, Chrousos G, Bornstein SR, McKay RD, Androutsellis- Theotokis A. (2015) Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications. Stem Cells Transl Med. 4(11):1251-7. doi: 10.5966/sctm.2015-0105. Epub 2015 Sep 14.

561. Zannas AS, Chrousos GP. (2015) Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition. Sci Signal. 8(400): fs19. doi: 10.1126/scisignal.aad3022.

562. Moschovi M, Critselis E, Cen O, Adamaki M, Lambrou GI, Chrousos GP, Vlahopoulos S. (2015) Drugs acting on homeostasis: challenging cancer cell adaptation. Expert Rev Anticancer Ther. 15(12):1405-17. doi: 10.1586/14737140.2015.1095095. Epub 2015 Nov 2.

563. Nikolakopoulou P, Poser SW, Masjkur J, Fernandez Rubin de Celis M, Toutouna L, Andoniadou CL, McKay RD, Chrousos G, Ehrhart-Bornstein M, Bornstein SR, Androutsellis-Theotokis A. (2016) STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System? Horm Metab Res. 48(2):77-82. doi: 10.1055/s-0041-111699. Epub 2016 Jan 19.

564. Masjkur J, Poser SW, Nikolakopoulou P, Chrousos G, McKay RD, Bornstein SR, Jones PM, Androutsellis- Theotokis A. (2016) Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology. Diabetes. 65(2):314-30. doi: 10.2337/db15-1099.

565. Rogakou E P, Papadakis V and Chrousos GP. (2016) The Epigenetic Biomarker γΗ2ΑΧ from Bench to Clinical Trials. In Hollar D (ed), Epigenetics, the Environment, and Children‟s Health across Lifespans. Springer International Publishing, Switzerland, p. 93-115

566. Pervanidou P, Chrousos GP. (2016) Stress and Pedictric Obesity: Neurobiology and Behavior. Fam Rel. 65:85- 93

567. Alexopoulos A, Chrousos GP. (2016) Stress-related skin disorders. Rev Endocr Metab Disord. 17(3):295-304. doi: 10.1007/s11154-016-9367-y.

568. Livadas S, Chrousos GP. (2016) Control of the onset of puberty. Curr Opin Pediatr. 28(4): 551-558.

569. Pervanidou P, Chrousos GP. (2016) Neurobiology of PTSD. In: Disasters: Mental Health Context and Responses Edited by George N. Christodoulou, Juan E. Mezzich, Nikos G. Christodoulou and Dusica Lecic- Tosevski. Cambridge Scholars Publishing. p 111-121

570. Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. (2016) Diabetic Nephropathy in Type 1 Diabetes: A Review of Early Natural History, Pathogenesis and Diagnosis. Diabetes Metab Res Rev. 33(2). doi: 10.1002/dmrr.2841. Epub 2016 Oct 4. 116

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571. Kanaka-Gantenbein C, Kogia C, Abdel-Naser MB, Chrousos GP. (2016) Skin manifestations of growth hormone-induced diseases. Rev Endocr Metab Disord. 17(3):259-267. doi: 10.1007/s11154-016-9378-8.

572. Kolaitis G, Pervanidou P, Giannakopoulos G, Chrousos GP. (2016) Chapter 1.Traffic Accidents: Epidemiology, Risk Factors, Psychosocial and Neuroendocrine Impact on Children and Adolescents. In: Traffic Accidents and Safety: New Research. Ed: G.Bowman, Nova Science Publishers, New York, 1-18

573. Charmandari E, Chrousos GP. (2016) Chapter 15. The Effect of Stress on the Hypothalamic-pituitary Adrenal Axis: An Update. In. Neuroendocrine Disorders in Children, Eds: Dattani M, Hindmarsh P, Carr L and Robinson CAF, McKeith Press, London p 218-233

574. Zouboulis CC, Stratakis CA, Chrousos GP, Koch CA. (2016) Metabolism and Skin Diseases. Rev Endocr Metab Disord. 17(3):241-246. doi: 10.1007/s11154-016-9396-6.

575. Contorregi C, Chrousos GP, Di Mascio M. (2016) Chronic distress and the vulnerable host: a new target for HIV treatment and prevention? Neurobehavioral HIV Medicine 2016 https://www.dovepress.com/articles.php?article_id=30670&l=R4Q8CaHOkCYPalsfVmXSRF7H225024

576. Gassen NC, Chrousos GP, Binder EB, Zannas AS. (2017) Life stress, glucocorticoid signaling, and the aging epigenome: implications for aging-related diseases. Neurosci Biobehav Rev. 74(Pt B):356-365. doi: 10.1016/j.neubiorev.2016.06.003. Epub 2016 Jun 23.

577. Fotiou C, Siahanidou T, Vlastarakos PV, Tavoulari EF, Chrousos G. (2017) The effect of body and mind stress-releasing techniques on the breastfeeding of full-term babies; a critical analysis of published interventional studies. J Matern Fetal Neonatal Med. 1-26. doi: 10.1080/14767058.2016.1275547. [Epub ahead of print]

578. Chrousos GP, Zoumakis E. (2017) Milestones in CRH Research. Curr Mol Pharmacol. 10(4):259-263. doi: 10.2174/1874467210666170109165219.

579. Stavrou S, Nicolaides NC, Critselis E, Darviri C, Charmandari E, Chrousos GP. (2017) Pediatric Stress: From Neuroendocrinology to Contemporary Disorders. Eur J Clin Invest. 47(3):262-269. doi: 10.1111/eci.12724. Epub 2017 Feb

580. Leka-Emiri S, Chrousos GP, Kanaka-Gantenbein C. (2017) The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). J Endocrinol Invest. 40(8):789-802. doi: 10.1007/s40618-017-0627-9. Epub 2017 Mar 1.

581. Zannas AS, Chrousos GP. (2017) Epigenetic programming by stress and glucocorticoids along the human lifespan. Mol Psychiatry. 22(5):640-646. doi: 10.1038/mp.2017.35. Epub 2017 Mar 14.

582. Karalexi MA, Dessypris N, Skalkidou A, Biniaris-Georgallis S-, Kalogirou ΕΙ, Thomopoulos TP, Herlenius E, Spector LG, Loutradis D, Chrousos GP, Petridou ET. (2017) Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis. Cancer Causes Control. 28(6):599-624. doi: 10.1007/s10552-017-0890-2. Epub 2017 Apr 11.

583. Karatzi K, Protogerou AD, Moschonis G, Tsirimiagou C, Androutsos O, Chrousos GP, Lionis C, Manios Y. (2017) Reply to: "Considerations about: "Prevalence of hypertension and hypertension phenotypes by age and gender among schoolchildren in Greece: The Healthy Growth Study"". Atherosclerosis. pii: S0021- 9150(17)30153-3. doi: 10.1016/j.atherosclerosis.2017.04.006. [Epub ahead of print]

584. Kosteria I, Anagnostopoulos AK, Kanaka-Gantenbein C, Chrousos GP, Tsangaris GT. (2017) The Use of Proteomics in Assisted Reproduction. In Vivo. 31(3):267-283. Review. doi: 10.21873/invivo.11056.

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585. Nicolaides NC, Charmandari E, Kino T, Chrousos GP. (2017) Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health. Front Endocrinol (Lausanne). 8:70. doi: 10.3389/fendo.2017.00070. eCollection 2017. Review.

586. Chrousos GP, Belgorosky A. (2017) Adrenal Section In Hochberg Z. Practical Algorithms in Pediatric Endocrinology. Karger Publ. Basel. P44-54

587. Chrousos GP. Working Group. (2017) WHO Classification of Tumours of Endocrine Organs. Eds. RV Lloyd, Osamura RY, Kloeppel G, Rosai J. WHO 4th Edition, IARC, Lyon

588. Stefanaki C, Peppa M, Mastorakos G, Chrousos GP. (2017) Examining the gut bacteriome, virome, and mycobiome in glucose metabolism disorders: Are we on the right track? Metabolism. 73:52-66. doi: 10.1016/j.metabol.2017.04.014. Epub 2017 May 1. Review.

589. Georgoulis A, Vorgias CE, Chrousos GP, Rogakou EP. (2017) Genome Instability and γH2AX. Int J Mol Sci. 18(9). pii: E1979. doi: 10.3390/ijms18091979. Review.

590. Al-Daghri NM, Batzel JJ, Burgmann H, Carbone F, Charmandari E, Chrousos GP, Distelmaier K, Cvirn G, Dullaart RPF, Dumitrascu DL, Esteve-Pastor MA, Gervasini G, Goliasch G, Goswami N, Gruppen EG, Hernández-Mijares A, Kalantaridou SN, Krause R, Latini R, Makrigiannakis A, Marín F, Masson S, Montecucco F, Ndrepepa G, Nicolaides NC, Novelli D, Orasan OH, Qorbani M, Ratzinger F, Roessler A, Sabico S, Sciatti E, Stefanaki C, Stoner L, Tabatabaei-Malazy O, Tatar E, Toz H, Uslu A, Victor VM, Vizzardi E. (2017) Research update for articles published in EJCI in 2015. Eur J Clin Invest. 47(10):775-788. doi: 10.1111/eci.12819. No abstract available.

591. Papadopoulou-Marketou N, Kanaka-Gantenbein C, Marketos N, Chrousos GP, Papassotiriou I. (2017) Biomarkers of diabetic nephropathy: A 2017 update. Crit Rev Clin Lab Sci. 54(5):326-342. doi: 10.1080/10408363.2017.1377682. Epub 2017 Sep 28.

592. Mavrogeni S, Pons R, Nikas I, Papadopoulos G, Verganelakis DA, Kolovou G, Chrousos GP. (2017) Brain and Heart Magnetic Resonance Imaging/Spectroscopy in Duchenne Muscular Dystrophy. Eur J Clin Invest. 47(12). doi: 10.1111/eci.12842. Epub 2017 Oct 26.

593. Geronikolou SA, Pavlopoulou A, Cokkinos D, Chrousos G. (2017) Interactome of Obesity: Obesidome: Genetic Obesity, Stress Induced Obesity, Pathogenic Obesity Interaction. Adv Exp Med Biol. 987:233-241. doi: 10.1007/978-3-319-57379-3_21. PMID: 28971462

594. Geronikolou SA, Albanopoulos K, Chrousos G, Cokkinos D. (2017) Evaluating the Homeostasis Assessment Model Insulin Resistance and the Cardiac Autonomic System in Bariatric Surgery Patients: A Meta-Analysis. Adv Exp Med Biol. 988:249-259. doi: 10.1007/978-3-319-56246-9_20.

595. Mavrogeni S, Papavasiliou A, Giannakopoulou K, Markousis-Mavrogenis G, Pons MR, Karanasios E, Nikas I, Papadopoulos G, Kolovou G, Chrousos GP. (2017) Oedema-fibrosis in Duchenne Muscular Dystrophy. Role of Cardiovascular Magnetic Resonance Imaging. Eur J Clin Invest. 47(12). doi: 10.1111/eci.12843. Epub 2017 Oct 31.

596. Rizos CV, Athyros V, Bilianou E, Chrousos G, Garoufi A, Kolovou G, Kotsis V, Rallidis L, Skalidis E, Skoumas I, Tziomalos K, Liberopoulos EV. (2017) An insight into familial hypercholesterolemia in Greece: rationale and design of the Hellenic Familial Hypercholesterolemia Registry (HELLAS-FH). Hormones (Athens). 16(3):200-204. doi: 10.14310/horm.2002.1749.

597. Vlachakis D, Zacharaki EI, Tsiamaki E, Koulouri M, Raftopoulou S, Papageorgiou L, Chrousos GP, Ellul J, Megalooikonomou V. (2017) Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly. J Mol Biochem. 6:41-44. Epub 2017 Dec 10.

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598. Papageorgiou L, Vlachakis C, Dragoumani K, Raftopoulou S, Brouzas D, Nicolaides NC, Chrousos GP, Charmandari E, Megalooikonomou V, Vlachakis D. (2017) HCV genetics and genotypes dictate future antiviral strategies. J Mol Biochem. 6:33-40. Epub 2017 Dec 10.

599. Kapogiannis A, Tsoli S, Chrousos G. (2017) Investigating the Effects of the Progressive Muscle Relaxation- Guided Imagery Combination on Patients With Cancer Receiving Chemotherapy Treatment: A Systematic Review of Randomized Controlled Trials. Explore (NY). pii: S1550-8307(17)30031-9. doi: 10.1016/j.explore.2017.10.008. [Epub ahead of print]

600. Bougea A, Spantideas N, Chrousos GP. (2018) Stress management for headaches in children and adolescents: A review and practical recommendations for health promotion programs and well-being. J Child Health Care. 22(1):19-33. doi: 10.1177/1367493517738123. Epub 2017 Nov 1.

601. Paschou SA, Papadopoulou-Marketou N, Chrousos G, Kanaka-Gantenbein C. (2018) On type 1 diabetes mellitus pathogenesis. Endocr Connect. 7(1):R38-R46. doi: 10.1530/EC-17-0347. Epub 2017 Nov 30.

602. Geronikolou SA, Pavlopoulou A, Kanaka-Gantenbein C, Chrousos G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Front Biosci (Elite Ed). 10:208-228.

603. Moris D, Felekouras E, Chrousos GP. (2018) No Cytokine Is an Island: IL-6 Alone Is not Sufficient to Predict Morbidity after a Major Abdominal Surgery. Ann Surg. 267(2):e30-e32. doi: 10.1097/SLA.0000000000001977.

604. Kassari P, Papaioannou P, Billiris A, Karanikas H, Eleftheriou S, Thireos E, Manios Y, Chrousos GP, Charmandari E. (2018) Electronic Registry for the Management of Childhood Obesity in Greece. Eur J Clin Invest. 48(3). doi: 10.1111/eci.12887. Epub 2018 Feb 11.

605. Wahrborg P, Pervanidou P, Chrousos GP. (2018) The Physiology of Stress and Stress Recovery. Chapter 1.4, Oxford Textbook of Nature and Public Health: The Role of Nature in Improving the Health of a Population. M. van der Bosch, William Bird. Oxford Univ Press, Oxford p33-39

606. Kosteria I, Kanaka-Gantenbein C, Anagnostopoulos AK, Chrousos GP, Tsangaris GT. (2018) Pediatric endocrine and metabolic diseases and proteomics. J Proteomics. 188:46-58. doi: 10.1016/j.jprot.2018.03.011. Epub 2018 Mar 18.

607. Stefanaki C, Pervanidou P, Boschiero D, Chrousos GP. (2018) Chronic stress and body composition disorders: implications for health and disease. Hormones (Athens). 17(1):33-43. doi: 10.1007/s42000-018-0023-7. Epub 2018 Apr 27. Review.

608. Chrousos GP, Pervanidou P, Dalla C. (2018) Mini-reviews based on the First Conference of the Institute of Stress Biology & Medicine "Systems Biology-Medicine and Stress". Hormones (Athens). 17(1):3-4. doi: 10.1007/s42000-018-0027-3. No abstract available.

609. Tsartsalis AN, Lambrou GI, Tsartsalis D, Savvidis C, Karantza M, Terpos E, Kanaka-Gantenbein C, Chrousos GP, Kattamis A. (2018) The role of biphosphonates in the management of thalassemia-induced osteoporosis: a systematic review and meta-analysis. Hormones (Athens). 17(2):153-166. doi: 10.1007/s42000-018-0019-3. Epub 2018 May 2.

610. Mavrogeni SI, Bacopoulou F, Apostolaki D, Chrousos GP. (2018) Sudden cardiac death in athletes and the value of cardiovascular magnetic resonance. Eur J Clin Invest. 48(7):e12955. doi: 10.1111/eci.12955. Epub 2018 Jun 4. Review.

611. Pervanidou P, Chrousos GP. (2018) Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related Disorders. Horm Res Paediatr. 89(5):372-379. doi: 10.1159/000488468. Epub 2018 Jun 8.

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612. Nicolaides N, Chrousos G. (2018) Bilateral adrenal hyperplasia and NR3C1 mutations causing glucocorticoid resistance: Is there an association? Eur J Endocrinol. 179(5):C1-C4. doi: 10.1530/EJE-18-0471.

613. Agorastos A, Pervanidou P, Chrousos GP, Kolaitis G. (2018) Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation. Hormones (Athens). 17(4):507-520. doi: 10.1007/s42000-018-0065-x. Epub 2018 Oct 2.

614. EAS Familial Hypercholesterolaemia Studies Collaboration; EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) Investigators. (2018) Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Atherosclerosis. 277:234-255. doi: 10.1016/j.atherosclerosis.2018.08.051.

615. Chrousos GP. (2018) Hellenistic Medicine and the Library of Alexandria: Its Influence in the West and the East. In: Hellenistic Alexandria: Celebrating 24 Centuries. Eds. C.S. Zerefos, M. V.Vardinoyannis. Archaeopress, Oxford. p277-280

616. Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G, Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A, Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A, Lenders JW, Eisenhofer G, Andoniadou CL. (2019) Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease? Mol Psychiatry. 24(1):2-9. doi: 10.1038/s41380-018- 0244-9. Epub 2018 Sep 21.

617. Paschou SΑ, Kanaka-Gantenbein C, Chrousos GP, Vryonidou A. (2019) Growth hormone axis in patients with chronic kidney disease. Hormones (Athens). 18(1):71-73. doi: 10.1007/s42000-018-0066-9. Epub 2018 Sep 25.

618. Valsamakis G, Chrousos G, Mastorakos G. (2019) Stress, female reproduction and pregnancy. Psychoneuroendocrinology. 100:48-57. doi: 10.1016/j.psyneuen.2018.09.031. Epub 2018 Sep 22.

619. Karageorgiou V, Papaioannou TG, Bellos I, Alexandraki K, Tentolouris N, Stefanadis C, Chrousos GP, Tousoulis D. (2019) Effectiveness of artificial pancreas in the non-adult population: a systematic review and network meta-analysis. Metabolism. 90:20-30. doi: 10.1016/j.metabol.2018.10.002. Epub 2018 Oct 12.

620. Xatzipsalti M, Voutetakis A, Stamoyannou L, Chrousos GP, Kanaka-Gantenbein C. (2019) Congenital Hypopituitarism: Various Genes, Various Phenotypes. Horm Metab Res. 51(2):81-90. doi: 10.1055/a-0822- 3637. Epub 2019 Feb 13.

621. Angelousi A, Kassi E, Nasiri-Ansari N, Randeva HS, Kaltsas GA, Chrousos GP. (2019) Clock genes and cancer development in particular in endocrine tissues. Endocr Relat Cancer. 26(6):R305-R317. doi: 10.1530/ERC-19-0094. Review.

622. Panagopoulos DJ, Chrousos GP. (2019) Shielding methods and products against man-made Electromagnetic Fields: Protection versus risk. Sci Total Environ. 667:255-262. doi: 10.1016/j.scitotenv.2019.02.344. Epub 2019 Feb 23.

623. Agorastos A, Pervanidou P, Chrousos GP, Baker DG. (2019) Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation. Front Psychiatry. 10:118. doi: 10.3389/fpsyt.2019.00118. eCollection 2019. Review.

624. Tzifi F, Fretzayas A, Chrousos G, Kanaka-Gantenbein C. Non-alcoholic fatty liver infiltration in children: an underdiagnosed evolving disease. Hormones (Athens). 2019 May 28. doi: 10.1007/s42000-019-00107-7. [Epub ahead of print] Review.

625. Paschou SA, Tsamis KI, Kanaka-Gantenbein C, Johnson EO, Chrousos GP. (2019) Neurobehavioral and neuroendocrine regulation of energy homeostasis. Postgrad Med. 131(7):413-414. doi: 10.1080/00325481.2019.1654837. Epub 2019 Aug 16.

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626. Mentis AF, Chrousos GP. (2019) Springboard to Science from the “Worn Out Niche” of a Research Resources- limited Environment: Greece Must Get Serious about Research and Development. Eur J Clin Invest. 49(11):e13167. doi: 10.1111/eci.13167. Epub 2019 Oct 9.

627. Chrousos GP, Mammas IN, Spandidos DA. (2019) The role of philosophy in medical practice. Exp Ther Med. 18(4):3215-3216. doi: 10.3892/etm.2019.7944. Epub 2019 Aug 28. No abstract available. PMID: 31572560

628. Mammas IN, Theodoridou M, Spandidos DA. (2019) The wisdom and eudaimonia of Paediatrics: An interview with Professor George P. Chrousos, Professor of Paediatrics and Endocrinology at the University of Athens, Greece. Exp Ther Med. 8(4):3217-3220. doi: 10.3892/etm.2019.7945. Epub 2019 Aug 28.

629. Khachane Y, Kozlowska K, Savage B, McClure G, Butler G, Gray N, Worth A, Mihailovich S, Perez DL, Helgeland H, Chrousos GP. (2019) Twisted in Pain: The Multidisciplinary Treatment Approach to Functional Dystonia. Harv Rev Psychiatry. 27(6):359-381. doi: 10.1097/HRP.0000000000000237.

630. Straube R, Müller G, Voit-Bak K, Tselmin S, Julius U, Schatz U, Rietzsch H, Reichmann H, Chrousos GP, Schürmann A, Jarc L, Ziemssen T, Siepmann T, Bornstein SR. (2019) Metabolic and Non-Metabolic Peripheral Neuropathy: Is there a Place for Therapeutic Apheresis? Horm Metab Res. 51(12):779-784. doi: 10.1055/a-1039-1471. Epub 2019 Dec 11.

631. Livadas S, Chrousos GP. (2019) Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach. Front Endocrinol (Lausanne). 10:828. doi: 10.3389/fendo.2019.00828. eCollection 2019. Review.PMID: 31920956

632. Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R. (2020) Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation. Mol Psychiatry. 25(2):275-282. doi: 10.1038/s41380-019-0542-x. Epub 2019 Oct 8. Review.

633. Nicolaides N, Chrousos GP. (2020) Adrenal Cortex Hormones. In: Hormone Signaling in Biology and Medicine, Ed. Litwack G. Academic Press. p 619-633

634. Nicolaides NC, Chrousos GP. (2020) Sex Differences in Circadian Endocrine Rhythms: Clinical Implications. Eur J Neurosci. 52(1):2575-2585. doi: 10.1111/ejn.14692. Epub 2020 Feb 28.

635. Chrousos GP, Mentis A-F. (2020) Imposter syndrome threatens diversity. Science. 367(6479):749-750. doi: 10.1126/science.aba8039.

636. Agorastos A, Nicolaides NC, Bozikas VP, Chrousos GP, Pervanidou P. (2020) Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress. Front Psychiatry. 10:1003. doi: 10.3389/fpsyt.2019.01003. eCollection 2019.

637. Panagopoulos DJ, Balmori A, Chrousos GP. (2020) On the biophysical mechanism of sensing upcoming earthquakes by animals. Sci Total Environ. 717:136989. doi: 10.1016/j.scitotenv.2020.136989. Epub 2020 Jan 29.

638. Angelopoulou E, Anagnostouli M, Chrousos GP, Bougea A. (2020) Massage therapy as a complementary treatment for Parkinson's disease: A Systematic Literature Review. Complement Ther Med. 49:102340. doi: 10.1016/j.ctim.2020.102340. Epub 2020 Feb 6.

639. Pervanidou P, Makris G, Chrousos G, Agorastos A. (2020) Early Life Stress and Pediatric Posttraumatic Stress Disorder. Brain Sci. 10(3):169. doi: 10.3390/brainsci10030169.

640. Zannas AS, Stein MB, Chrousos GP. (2020) Editorial: Molecular Mechanisms in Stress and Trauma Related Disorders. Front Psychiatry. 11:103. doi: 10.3389/fpsyt.2020.00103. eCollection 2020. No abstract available. PMID: 32194451 121

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641. Chrousos GP, Mentis AA. (2020) Medical misinformation in mass and social media: an urgent call for action, especially during epidemics. Eur J Clin Invest. 50(5):e13227. doi: 10.1111/eci.13227. Epub 2020 May 5.

642. Zannas AS, Chrousos GP, Stein MB. (2020) Issue: Molecular Mechanisms in Stress and Trauma Related Disorders. Frontiers in Psychiatry 2020: Volume 11.

643. Chrousos GP, Mentis A-F A, Dardiotis E. (2020) Biomedical research: lessons from the last decade‟s crisis and austerity-stricken small countries for the current COVID-19-related crisis. Nat Med. 26(5):644-646. doi: 10.1038/s41591-020-0859-7.

644. Panagiotakos DB, Magriplis E, Zampelas A; Contributors; Advisory Committee. (2020) The re-calibrated HellenicSCORE based on newly derived risk factors from the Hellenic National Nutrition and Health Survey (HNNHS); the HellenicSCORE II. Hellenic J Cardiol. S1109-9666(20)30073-7. doi: 10.1016/j.hjc.2020.03.006. Online ahead of print.

645. Mentis A-F A, Dardiotis E, Chrousos GP. (2020) Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework. Mol Psychiatry. doi: 10.1038/s41380-020-0731-7. Online ahead of print.

646. Meduri GU, Chrousos GP. (2020) General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections. Front Endocrinol (Lausanne).11:161. doi: 10.3389/fendo.2020.00161. eCollection 2020.

647. Nicolaides ΝC, Kanaka-Gantenbein C, Papadopoulou-Marketou N, Sertedaki A, Chrousos GP, Papassotiriou I. (2020) Emerging Technologies in Pediatrics: The Paradigm of Neonatal Diabetes Mellitus. Crit Rev Clin Lab Sci. 1-10. doi: 10.1080/10408363.2020.1752141. Online ahead of print.

648. Vlachakis D, Papakonstantinou E, Efthimiadou A, Bacopoulou F, Goulielmos G, Chrousos GP, Eliopoulos E. (2020) Ancestral Cancer Genes Shaping Evo‐Devo: An Integrated biochemical and computational approach (Review) World Academy Sciences Journal 2:7.

649. Geronikolou SA, Johansson Ӧ, Chrousos G, Kanaka-Gantenbein C, Cokkinos D. (2020) Cellular Phone User's Age or the Duration of Calls Moderate Autonomic Nervous System? A Meta-Analysis. Adv Exp Med Biol. 1194:475-488. doi: 10.1007/978-3-030-32622-7_46. PMID: 32468564

650. Papageorgiou L, Maroulis D, Chrousos GP, Eliopoulos E, Vlachakis D. (2020) Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties. Adv Exp Med Biol.1194:41-58. doi: 10.1007/978-3-030-32622-7_4. PMID: 32468522

651. Raftopoulou S, Nicolaides NC, Papageorgiou L, Amfilochiou A, Zakinthinos SG, George P, Eliopoulos E, Chrousos GP, Vlachakis D. (2020) Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders. Adv Exp Med Biol. 1195:59-71. doi: 10.1007/978-3-030-32633-3_10.

652. Paschou SA, Vryonidou A, Melissourgou M, Kosteria I, Goulis DG, Chrousos GP, Kanaka-Gantenbein C. (2020) Menstrual Disorders And Androgen-Related Traits In Young Women With Type 1 Diabetes Mellitus: A Clinical Study. Endocr Pract. doi: 10.4158/EP-2020-0153. Online ahead of print. PMID: 32576049

653. Koumarianou A, Symeonidi AE, Kattamis A, Linardatou K, Chrousos GP, Darviri C. (2020) A review of psychosocial interventions targeting families of children with cancer. Palliat Support Care. 1-16. doi: 10.1017/S1478951520000449. Online ahead of print. PMID: 32613930

654. Mammas IN, Drysdale SB, Rath B, Theodoridou M, Papaioannou G, Papatheodoropoulou A, Koutsounaki E, Koutsaftiki C, Kozanidou E, Achtsidis V, Korovessi P, Chrousos GP, Spandidos DA. (2020) Update on current views and advances on RSV infection (Review). Int J Mol Med. doi: 10.3892/ijmm.2020.4641. Online ahead of print. PMID: 32626981 122

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655. Moutsopoulos HΜ, Chrousos GP. The "Distinguished" Physician-Scientist: Is a single bibliometric index sufficient for distinction? Clin Immunol. 2020 Jul 27:108546. doi: 10.1016/j.clim.2020.108546. Online ahead of print. PMID: 32730866

656. Chrousos GP, Meduri GU. Critical COVID-19 disease, homeostasis, and the "surprise" of effective glucocorticoid therapy. Clin Immunol. 2020 July 31:108550. doi: 10.1016/ j. clim. 2020.108550. Online ahead of print. PMID: 32745524

657. Mitsis T, Pierouli K, Diakou KI, Papakonstantinou E, Bacopoulou F, Chrousos GP, Vlachakis D (2020) Exosomics, EMBnet.journal 26, e934 http://dx.doi.org/10.14806/ej.26.0.934

658. Chrousos GP, Mentis AA, Dardiotis E. Focusing on the Neuro-Psycho-Biological and Evolutionary Underpinnings of the Imposter Syndrome. Front Psychol. 2020;11:1553. Published 2020 Jul 20. doi:10.3389/fpsyg.2020.01553

659. Nicolaides NC, Chrousos GP. Sex differences in circadian endocrine rhythms: Clinical implications. Eur J Neurosci. 2020; 52:2575–2585. https://doi.org/10.1111/ejn.1469

660. Piaditis GP, Kaltsas G, Markou A, Chrousos GP. Five Reasons for the Failure to Diagnose Aldosterone Excess in Hypertension [published online ahead of print, 2020 Sep 3]. Horm Metab Res. 2020;10.1055/a-1236-4869. doi:10.1055/a-1236-4869

C. BOOKS

1. Chrousos GP, Loriaux DL, Lipsett MB. (Eds) (1986) Steroid Hormone Resistance: Mechanisms and Clinical Aspects. In the Series: Advances in Experimental Medicine and Biology, Vol. 196, Plenum Press, New York, (439 pages, ISBN 0-306-42229-8).

2. D'Agata R, Chrousos GP. (Eds) (1987) Recent Advances in Adrenal Regulation and Function. Serono Symposia Series, Vol. 40, Raven Press, New York, (311 pages, ISBN-0-8816-178-9).

3. Chrousos GP, Loriaux DL, Gold PW. (Eds) (1988) Mechanisms of Physical and Emotional Stress. In the Series: Advances in Experimental Medicine and Biology, Vol. 245, Plenum Press, New York. (542 pages, ISBN-0-306-430-177).

4. Ludecke D, Chrousos GP, Tolis G. (Eds) (1990) Cushing's Syndrome and Other Hypercortisolemic States. In the Series: Progress in Endocrine Research and Therapy, Vol. 5, Raven Press, New York (318 pages, ISBN-0- 88167-718-3).

5. Tolis G, Bringer J, Chrousos GP. (Eds.) (1993) Intraovarian Regulators and the Polycystic-Ovary Syndrome. Ann. New York Acad. Sci., Vol. 687, New York (320 pages, ISBN-089 766-779-4 and 0-89 766-780-8).

6. Chrousos GP, McCarty R, Cizza G, Pacak K, Sternberg E, Gold PW, Kvetnanski R. (Eds.) (1995) Stress: Mechanisms and Clinical Implications. Ann. New York Acad. Sci., Vol. 771, New York. (755 pages, ISBN 0- 89766-943-6, cloth; 0-89766-944-4, paper).

7. Creatsas G, Mastorakos G, Chrousos GP. (Eds.) (1997) Adolescent Gynecology and Endocrinology: Basic and Clinical Aspects. Ann. New York Acad. Sci., Vol. 816, New York. (470 pages, ISBN 1-57331-038-7, cloth; 1-57331-039-5, paper).

8. McCann S, Sternberg EM, Lipton J, Chrousos GP, Gold PW, Smith C. (Eds.) (1998) Neuroimmunomodulation: Molecular Aspects, Integrative Systems and Clinical Advances. Ann. N.Y. Acad. Sci. Vol. 840, New York (866 pages, ISBN 1-57331-072-7, cloth; 1-57331-073-5, paper).

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9. Creatsas G, Mastorakos G, Chrousos GP. (Eds) (2000) “The Young Woman at the Rise of the 21st Century: Gynecological and Reproductive Issues in Health and Disease,” Ann. N.Y. Acad. Sci. 900: (445 pages, ISBN 1-57331-227-4).

10. Margioris AN, Chrousos GP. (Eds) (2001) Adrenal Disorders. Humana Press: Totowa, New Jersey, (424 pages, ISBN 0-89603-411-1).

11. Chrousos GP, Olefsky JM, Samols E. (Eds) (2002) Hormone Resistance and Hypersensitivity States. In Modern Endocrinology Series. Lippincott, Williams and Wilkins Publ. Co. Philadelphia Pa. (542 pages, ISBN 0-7817-1497-4).

12. Chrousos GP. (Editor-in-chief) (2002-) Pediatric Endocrinology Electronic Textbook, www.eMedicine.com

13. Chrousos GP. (Associate Editor) (2003-) Adrenal Diseases. On-line Textbook, Endocrinology and Metabolism, www.Endotext .com

14. Chrousos GP. (Associate Editor) (2004) Adrenal Physiology and Disorders. Encyclopedia of Endocrinology and Endocrine Disorders, Elsevier, Academic Press, Oxford, UK, and San Diego, CA. ISBN 0-12-475570-4 (set of 4 volumes)

15. Creatsas G, Mastorakos G, Chrousos GP. (Eds) (2003) “Challenges on Women‟s Health and Disease. Ann. N.Y. Acad. Sci. Vol. 997 (390 pages, ISBN 1-57331-458-7).

16. Geenen V, Chrousos GP. (Eds) (2004) Immunoendocrinology in Health and Disease. Marcel Dekker Inc. New York (ISBN: 0-8247-5060-8).

17. Chrousos GP, Associate Editor (2007) Encyclopedia of Stress, 2nd Edition Elsevier, Academic Press, Oxford, UK, and San Diego, CA. (set of 3 volumes, ISBN: 978-0-12-088503-9).

18. Kino T, Charmandari E, Chrousos G. (Eds) (2004) Glucocorticoid Action: Basic and Clinical Implications Ann N Y Acad Sci. Vol 1024 (221 pages, ISBN: 1-57331-557-5).

19. Alesci S, Manoli I, Costello R, Oates P, Gold PW, Chrousos GP, Blackman M. (Eds) (2004) Carnitine: The Science behind a Conditionally Essential Nutrient. Ann NY Acad Sci. Vol 1033 (199 pages, ISBN: 1-57331- 555 -9).

20. Chrousos GP, Tsigos C. (Eds) (2006) Stress, Obesity, and Metabolic Syndrome. Ann NY Acad Sci. Vol 083, published Nov 2006 (345 pages, ISBN: 1-57331-625-3).

21. Chrousos GP, Kaltsas GA, Mastorakos G. (2006) Neuroendocrine and Immune Crosstalk. Ann NY Acad Sci. Vol 1088, published Nov 2006 (412 pages, ISBN: 1-57331-623-7).

22. Creatsas G, Mastorakos G, Chrousos GP. (Eds) (2006) Women's Health and Disease: Gynecologic, Endocrine, and Reproductive Issues. Ann NY Acad Sci. Vol 1092 (482 pages, ISBN: 0077-8923).

23. Pandi-Perumal SR, Cardinali DP, Chrousos GP. (Eds) (2007) Neuroimmunology of Sleep. Springer Corp. (361 pages, ISBN: 0-387-69144-8).

24. del Rey A, Chrousos G, Besedovsky H. Eds (2008) Neuroimmune Biology Vol 7. The Hypothalamus- Pituitary-Adrenal Axis. Elsevier Co Oxford UK (394 pages, ISBN 978-0-444-53040-0).

25. Antoniou ASG, Cooper CL, Chrousos GP, Spielberger CD, Eysenck MW. (Eds) (2009) Handbook of Managerial Behavior and Occupational Health. Edward Elgar Cheltenham Publishing Co, UK, Northhampton MA, USA (452 pages, ISBN 978 1 848440951).

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26. Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff D. (Eds) (2010) Progress in Brain Research, Volume 181: Neuroendocrinology: The Normal Neuroendocrine System, 1st Edition, Elsevier Science (ISBN: 9780444536174).

27. Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff D. (Eds) (2010) Progress in Brain Research, Volume 182: Neuroendocrinology: Pathological Situations and Diseases, 1st Edition, Elsevier Science (ISBN: 9780444537393).

28. Ghizzoni L, Cappa M, Chrousos G, Loche S, Magghnie M. (Eds) (2011) Pediatric Adrenal Diseases. In the Series: Endocrine Development Vol 20 S Karger AG. Basel (216 pages, ISBN 978-3-8055-9643-5).

29. Koch CA, Chrousos GP. (Eds) (2013) Endocrine Hypertension: Underlying Mechanisms and Therapy Series: Contemporary Endocrinology 2013, XIII, 317 p. Humana Press Hardcover, Springer (317 pages, 33 illus., 26 in color, ISBN 978-1-60761-547-7).

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