Anti-KCNMB2 Monoclonal Antibody, Clone T64-43 (DCABH-10309) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-KCNMB2 monoclonal antibody, clone T64-43 (DCABH-10309) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to KCNMB2

Antigen Description Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

Specificity No cross-reactivity against BKBeta1, BKBeta3 or BKBeta4. Not yet validated for use in mammalian brain.

Immunogen Fusion protein corresponding to amino acids 1 - 41 (MFIWTSGRTS SSYRQDEKRN IYQKIRDHDL LDKRKTVTAL K; N-terminus) and 218 - 235 (KLTQYLSLLC ERIQRINR; C- terminus) of Mouse KCNMB2 (UniProt ID: Q9CZM9).

Isotype IgG1

Source/Host Mouse

Species Reactivity Mouse

Clone T64-43

Purity Protein G purified

Conjugate Unconjugated

Applications WB, IHC-P, IHC-Fr, ICC/IF

Positive Control Lysate from COS-1 cells transfected with KCNMB2

Format Liquid

Size 100 μg

Buffer Preservative: 0.09% Sodium Azide; Constituents: 50% Glycerol, PBS, pH 7.4

Preservative 0.09% Sodium Azide

Storage Store at -20°C. Stable for 12 months at -20°C

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name Kcnmb2 potassium large conductance calcium-activated channel, subfamily M, beta member 2 [ Mus musculus ]

Official Symbol KCNMB2

Synonyms KCNMB2; potassium large conductance calcium-activated channel, subfamily M, beta member 2; calcium-activated potassium channel subunit beta-2; BKbeta2; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; maxi K channel subunit beta-2; charybdotoxin recep

Entrez Gene ID 72413

Protein Refseq NP_082507

UniProt ID Q9CZM9

Pathway Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism- specific biosystem; Platelet homeostasis, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem; cGMP effects, organism-specific biosystem;

Function calcium-activated potassium channel activity; ion channel activity; potassium channel activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]