MUL1 Antibody Cat. No.: 56-663

MUL1 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Monkey

This MUL1 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 272-301 amino acids from the C-terminal region of human MUL1.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 40 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

September 25, 2021 1 https://www.prosci-inc.com/mul1-antibody-56-663.html CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MUL1

Mitochondrial ubiquitin ligase activator of NFKB 1, 632-, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, Mitochondrial- ALTERNATE NAMES: anchored protein ligase, MAPL, Putative NF-kappa-B-activating protein 266, RING finger protein 218, MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218

ACCESSION NO.: Q969V5

PROTEIN GI NO.: 74760689

GENE ID: 79594

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces BACKGROUND: caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

REFERENCES: 1) Laure, L., et al. FEBS J. 277(20):4322-4337(2010)

2) Braschi, E., et al. EMBO Rep. 10(7):748-754(2009)

3) Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)

4) Zhang, B., et al. Cell Res. 18(9):900-910(2008)

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 25, 2021 2 https://www.prosci-inc.com/mul1-antibody-56-663.html