Anti-GOSR1 / GS28 Antibody (ARG41211)

Product datasheet [email protected]

ARG41211 Package: 100 μl anti-GOSR1 / GS28 antibody Store at: -20°C

Summary

Product Description Rabbit Polyclonal antibody recognizes GOSR1 / GS28

Tested Reactivity Hu

Tested Application ICC/IF

Host Rabbit

Clonality Polyclonal

Isotype IgG

Target Name GOSR1 / GS28

Antigen Species Human

Immunogen Recombinant fusion protein corresponding to aa. 1-115 of Human GOSR1 / GS28 (NP_004862.1).

Conjugation Un-conjugated

Alternate Names GOS-28; Golgi SNAP receptor complex member 1; 28 kDa cis-Golgi SNARE p28; GOS28; GOLIM2; GOS28/P28; 28 kDa Golgi SNARE protein; GS28; P28

Application Instructions

Application table Application Dilution

ICC/IF 1:50 - 1:200

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Calculated Mw 29 kDa

Properties

Form Liquid

Purification Affinity purified.

Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.

Preservative 0.02% Sodium azide

Stabilizer 50% Glycerol

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation www.arigobio.com 1/2 Gene Symbol GOSR1

Gene Full Name golgi SNAP receptor complex member 1

Background This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. [UniProt]

Cellular Localization Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). [UniProt]

Images

ARG41211 anti-GOSR1 / GS28 antibody ICC/IF image

Immunofluorescence: U2OS cells stained with ARG41211 anti- GOSR1 / GS28 antibody at 1:100 dilution.