WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

WHI dbGaP Subject ID Variable # 1 Usage Notes: none Sas Name: SUBJID Categories: Sas Label: WHI dbGaP Subject ID

Ascertainment Source Ascertainment Source

Variable # 2 Usage Notes: This file has one row for every form 123 recording outcome(s). A participant may have more than one of these forms. Only the Sas Name: ASCSOURCE first occurrence of each outcome is counted, e.g. Limiting the file Sas Label: Ascertainment Source to rows where BKANKLE=1 will find a single row for each participant with an ankle fracture outcome. Values N % Categories: 1 Local Form 123 3,674 74.0% 2 Central Form 123 1,293 26.0% 4,967

Ankle Fracture Variable # 3 Usage Notes: Ankle Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics for OS Sas Name: BKANKLE participants. It was not adjudicated after the WHI study closeout. Sas Label: Ankle Fracture Ankle Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 512 10.3% . Missing 4,455 89.7% 4,967

Carpal Fracture Carpal bones in wrist

Variable # 4 Usage Notes: Carpal Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics for OS Sas Name: BKCARPAL participants. It was not adjudicated after the WHI study closeout. Sas Label: Carpal bones in wrist Carpal Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 65 1.3% . Missing 4,902 98.7% 4,967

Clavical Fracture Variable # 5 Usage Notes: Clavical Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKCLAVICLE for OS participants. It was not adjudicated after the WHI study Sas Label: Clavical Fracture closeout. Clavical Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 56 1.1% . Missing 4,911 98.9% 4,967

Page 1 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

Elbow NOS Fracture Elbow, not otherwise specified

Variable # 6 Usage Notes: Elbow NOS Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKELBOWNOS for OS participants. It was not adjudicated after the WHI study Sas Label: Elbow, not otherwise specified closeout. Elbow NOS Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 7 0.1% . Missing 4,960 99.9% 4,967

Hip Fracture Variable # 7 Usage Notes: is adjudicated for CT and OS participants. Sas Name: BKHIP Categories: Outcomes: Adjudicated Sas Label: Hip Fracture Values N % 1 Yes 1,293 26.0% . Missing 3,674 74.0% 4,967

Lower End of Variable # 8 Usage Notes: Lower End of Humerus Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density Sas Name: BKLELBOW clinics for OS participants. It was not adjudicated after the WHI Sas Label: Lower End of Humerus Fracture study closeout. Lower End of Humerus Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 42 0.8% . Missing 4,925 99.2% 4,967

Metacarpal Fracture Variable # 9 Usage Notes: Metacarpal Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKHAND for OS participants. It was not adjudicated after the WHI study Sas Label: Metacarpal Fracture closeout. Metacarpal Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 100 2.0% . Missing 4,867 98.0% 4,967

Page 2 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

Patella Fracture Variable # 10 Usage Notes: was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics for OS Sas Name: BKPATELLA participants. It was not adjudicated after the WHI study closeout. Sas Label: Patella Fracture Patella Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 133 2.7% . Missing 4,834 97.3% 4,967

Pelvis Fracture Variable # 11 Usage Notes: Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics for OS Sas Name: BKPELVIS participants. It was not adjudicated after the WHI study closeout. Sas Label: Pelvis Fracture Pelvis Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 142 2.9% . Missing 4,825 97.1% 4,967

Radius or Variable # 12 Usage Notes: or Ulna Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKLARM for OS participants. It was not adjudicated after the WHI study Sas Label: Radius or Ulna Fracture closeout. Radius or Ulna Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 861 17.3% . Missing 4,106 82.7% 4,967

Sacrum or Fracture Variable # 13 Usage Notes: or Coccyx Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKCOCCYX for OS participants. It was not adjudicated after the WHI study Sas Label: Sacrum or Coccyx Fracture closeout. Sacrum or Coccyx Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 43 0.9% . Missing 4,924 99.1% 4,967

Page 3 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

Scapula Fracture Variable # 14 Usage Notes: Scapula Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKSCAPULA for OS participants. It was not adjudicated after the WHI study Sas Label: Scapula Fracture closeout. Scapula Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 20 0.4% . Missing 4,947 99.6% 4,967

Shaft of Femur Fracture Variable # 15 Usage Notes: Shaft of Femur Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKUPPERLEG for OS participants. It was not adjudicated after the WHI study Sas Label: Shaft of Femur Fracture closeout. Shaft of Femur Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 48 1.0% . Missing 4,919 99.0% 4,967

Shaft of Humerus Fracture Fracture of humerus, shaft or unspecified part

Variable # 16 Usage Notes: Shaft of Humerus Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKOHUMERUS for OS participants. It was not adjudicated after the WHI study Sas Label: Fracture of humerus, shaft or unspecified part closeout. Shaft of Humerus Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 36 0.7% . Missing 4,931 99.3% 4,967

Tarsal or Metatarsal Fracture Variable # 17 Usage Notes: Tarsal or Metatarsal Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKFOOT for OS participants. It was not adjudicated after the WHI study Sas Label: Tarsal or Metatarsal Fracture closeout. Tarsal or Metatarsal Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 498 10.0% . Missing 4,469 90.0% 4,967

Page 4 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

Tibia or Fibula Fracture Variable # 18 Usage Notes: Tibia or Fibula Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKTIBIAFIBULA for OS participants. It was not adjudicated after the WHI study Sas Label: Tibia or Fibula Fracture closeout. Tibia or Fibula Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 251 5.1% . Missing 4,716 94.9% 4,967

Tibial Plateau Fracture Variable # 19 Usage Notes: Tibial Plateau Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKTIBIAL for OS participants. It was not adjudicated after the WHI study Sas Label: Tibial Plateau Fracture closeout. Tibial Plateau Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 69 1.4% . Missing 4,898 98.6% 4,967

Upper End of Humerus Fracture Variable # 20 Usage Notes: Upper End of Humerus Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density Sas Name: BKUHUMERUS clinics for OS participants. It was not adjudicated after the WHI Sas Label: Upper End of Humerus Fracture study closeout. Upper End of Humerus Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 336 6.8% . Missing 4,631 93.2% 4,967

Upper Radius/Ulna Fracture Variable # 21 Usage Notes: Upper Radius/Ulna Fracture was adjudicated at all clinics for CT participants. It was only adjudicated at the bone density clinics Sas Name: BKUELBOW for OS participants. It was not adjudicated after the WHI study Sas Label: Upper Radius/Ulna Fracture closeout. Upper Radius/Ulna Fracture is not counted if pathologic. Values N % Categories: Outcomes: Adjudicated 1 Yes 134 2.7% . Missing 4,833 97.3% 4,967

Page 5 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

Vertebral Fracture Variable # 22 Usage Notes: Defined as the first occurence of Lumbar Spine Fracture or Thoracic Spine Fracture. Vertebral Fracture was adjudicated at Sas Name: BKSPINE all clinics for CT participants. It was only adjudicated at the bone Sas Label: Vertebral Fracture density clinics for OS participants. It was not adjudicated after the WHI study closeout. Does not include cervical fractures. Values N % Categories: Outcomes: Adjudicated 1 Yes 321 6.5% . Missing 4,646 93.5% 4,967

F123 Fracture site (hip) Variable # 23 Usage Notes: Sas Name: HIPFSITE Categories: Sas Label: Fracture site (hip) Values N % 1 Neck of femur 783 15.8% 2 Intertrochanteric fracture 449 9.0% 3 Greater trochanter 35 0.7% 4 Unspecified part of proximal femur 26 0.5% . Missing 3,674 74.0% 4,967

F123 Side of hip fracture Variable # 24 Usage Notes: Sas Name: HIPFSIDE Categories: Sas Label: Side of hip fracture Values N % 1 Right 627 12.6% 2 Left 666 13.4% 3 Both sides 0 0.0% 9 Unknown 0 0.0% . Missing 3,674 74.0% 4,967

Page 6 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

F123 Hip Fracture Based On Variable # 25 Usage Notes: Not collected on early versions of F123. Value 5 was not collected after WHI closeout. Sas Name: HIPFBASE Categories: Sas Label: Hip Fracture Based On Values N % 1 Radiology & discharge summary 1,055 21.2% dx new hip fracture 2 Radiology dx of hip fx, but not on 86 1.7% discharge summary 3 Discharge, equiv. xray, unequiv. 14 0.3% scan/MRI dx hip fx 4 Hip fracture dx in discharge 136 2.7% summary, but no radiology rprt 5 Uncertain radiology report of hip 2 0.0% fracture without add. doc . Missing 3,674 74.0% 4,967

F123 (of hip) Pathologic hip fracture: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone or joint prostheses, or surgical manipulation.Osteoporotic fracture is not considered a pathologic fracture.)

Variable # 26 Usage Notes: Sas Name: HIPFPATH Categories: Sas Label: Pathologic fracture (of hip) Values N % 0 No 1,234 24.8% 1 Yes 34 0.7% 2 Possible 24 0.5% . Missing 3,675 74.0% 4,967

F123 Side of fracture (non hip) Variable # 27 Usage Notes: Not collected after WHI closeout. Sas Name: FRACSIDE Categories: Sas Label: F123 Side of fracture (non hip) Values N % 1 Right 1,548 31.2% 2 Left 1,688 34.0% 3 Both sides 33 0.7% 4 Not applicable (e.g. tailbone) 333 6.7% 9 Unknown 28 0.6% . Missing 1,337 26.9% 4,967

Page 7 of 8 12/22/2010 WHI Follow-Up Dataset Fracture Outcome Details (Form 123, data as of Aug 2009)

Data File: outc_fracture_dbgap_rel1 File Date: 12/16/2010 Structure: Multiple rows per participant Population: WHI dbGaP Cohort participants with fracture outcomes

F123 Fracture confirmed as (non hip) Variable # 28 Usage Notes: Not collected after WHI closeout. Sas Name: FRACCONF Categories: Sas Label: F123 Fracture confirmed as (non hip) Values N % 1 Non vertebal: Radiology report new 2,531 51.0% fracture 2 Non vertebal: Radiology report 91 1.8% healing fracture 3 Non vertebal: Non radiology report 778 15.7% new/healing fracture 4 Non vertebal: Init. rad.report equiv., 36 0.7% subs report dx fract. 5 Vertebal: Radiology report based 151 3.0% on AP/lateral thoracolumbar 6 Vertebal: Radiology rprt not based 47 0.9% AP/lateral thoracolumbar . Missing 1,333 26.8% 4,967

F123 Pathologic fracture (non hip) Pathologic fracture other than hip: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone and joint prostheses, or surgical manipulation. Osteoporotic fracture is not considered a pathologic fracture.)

Variable # 29 Usage Notes: Not collected after WHI closeout. Non vertebral fractures are not counted if they are pathologic. Sas Name: FRACPATH Categories: Sas Label: F123 Pathologic fracture (non hip) Values N % 0 No 3,497 70.4% 1 Yes 13 0.3% 2 Possible 23 0.5% . Missing 1,434 28.9% 4,967

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