Supplementary Tab. 2a

Fold Gene name Gene symbol Accession no. SD change Structural Myosin VA (heavy polypeptide 12, myoxin) MYO5A NM_000259.1 3.02 1.22 Sarcoglycan, gamma (35kDa dystrophin-associated SGCG NM_000231.1 2.75 0.04 glycoprotein) Wiskott-Aldrich syndrome interacting protein WASPIP NM_003387.3 4.70 1.06 Bystin-like BYSL NM_004053.2 2.14 0.56 FAT tumor suppressor homolog 1 FAT NM_005245.1 3.88 0.93 Regulation of Transcription/Cell cycle AT rich interactive domain 4B (RBP1- like) ARID4B NM_016374.4 2.64 0.45 Brain abundant, membrane attached signal protein 1 BASP1 NM_006317.3 2.08 0.13 CCR4 carbon catabolite repression 4-like (S. cerevisiae) CCRN4L NM_012118.2 2.29 0.72 Distal-less homeo box 2 DLX2 NM_004405.2 2.68 0.73 Four and a half LIM domains 2 FHL2 NM_001450.3 2.46 0.55 Iroquois homeobox protein 3 IRX3 NM_024336.1 2.30 0.52 Nuclear factor (erythroid-derived 2)-like 2 NFE2L2 NM_006164.2 2.15 0.55 RRS1 ribosome biogenesis regulator homolog (S. RRS1 NM_015169.2 2.13 0.48 cerevisiae) Basic leucine zipper / W2 domains BZW2 NM_014038.1 2.00 0.11 Metabolism CDC14 cell division cycle 14 homolog B (S. cerevisiae) CDC14B NM_003671.2 2.63 0.09 Cathepsin Z CTSZ NM_001336.2 2.36 0.54 Cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A1 NM_000499.2 6.08 2.63 UDP-N-acetylgalactosaminyl-transferase (GalNAc-T) GALGT NM_001478.2 2.48 0.79 UDP-N- acetylgalactosaminyl-transferase 6 (GalNAc- GALNT6 NM_007210.2 3.11 0.03 T6) Glutathione S-transferase M3 (brain) GSTM3 NM_000849.3 3.51 0.23 Sideroflexin 1 SFXN1 NM_022754.3 2.40 0.00 Solute carrier family 2 (facilitated glucose transporter), SLC2A6 NM_017585.2 2.73 0.81 member 6 Solute carrier family 7 (cationic amino acid transporter), SLC7A5 NM_003486.4 2.75 0.51 member 5 Sulfotransferase family, cytosolic, 1A, phenol- SULT1A1 NM_001055.2 2.23 0.10 preferring, member 1 Cell Communications (Signaling (S), Cell Death (D), Growth/Proliferation(G/P)): GTP binding protein overexpressed in skeletal muscle GEM NM_181702.1 2.56 0.95 (S) Mitogen-activated protein kinase kinase kinase 8 (S) MAP3K8 NM_005204.2 2.43 0.52 3-phosphoinositide dependent protein kinase-1(S) PDPK1 NM_002613.1 2.39 0.32 RAS, dexamethasone-induced 1 (S) RASD1 NM_016084.3 2.53 0.97 Insulin-like growth factor binding protein 3 (G/P) IGFBP3 NM_000598.2 3.70 0.81 Mortality factor 4 (G/P) MORF4 NM_006792.2 2.29 0.34 Programmed cell death 4 (neoplastic transformation PDCD4 NM_014456.3 2.02 0.25 inhibitor) (D) Peripheral myelin protein 22 (G/P) PMP22 NM_153322.1 3.27 0.48 B-cell CLL/lymphoma 2, nuclear gene encoding BCL2 NM_000633.1 2.71 0.56 mitochondrial protein (S) ATP-binding cassette, sub-family G (WHITE), member ABCG2 NM_004827.1 4.63 0.93 2 (S) Annexin A9 (S) ANXA9 NM_003568.1 2.13 0.30 BMP and activin membrane-bound inhibitor homolog BAMBI NM_012342.1 2.06 0.23 (Xenopus laevis) (S) Decay accelerating factor for complement (CD55, DAF NM_000574.2 2.74 0.48 Cromer blood group system) (S) Potassium intermediate/small conductance calcium- KCNN4 NM_002250.2 3.12 0.38 activated channel, subfamily N, member 4 (S) (S,G/P) pathway inhibitor (lipoprotein-associated THBD NM_000361.2 2.49 0.52 inhibitor) (S) TFPI NM_006287.3 3.92 1.92 Other (Unknown function) ELOVL family member 5, (FEN1/Elo2, SUR4/Elo3- ELOVL5 NM_021814.2 2.30 0.00 like, yeast) fatso FTO XM_051200.5 2.00 0.04 LIM and cysteine-rich domains 1 LMCD1 NM_014583.2 4.08 0.20 Similar to BcDNA:GH11415 LOC151963 NM_178496.2 2.48 0.66 Similar to microtubule associated testis specific S/T LOC375449 NM_198828.1 3.32 0.22 protein kinase Lactamase, beta , nuclear gene encoding mitochondrial LACTB NM_032857.2 2.01 0.21 protein Hypothetical Hypothetical protein KIAA0802 XM_031357.5 3.34 1.02 Hypothetical protein LOC286343 XM_210019.1 2.44 0.60 Hypothetical protein LOC375313 XM_351520.1 3.45 1.12 Hypothetical gene supported by BX537645 LOC402587 XM_380139.1 2.16 0.04 Hypothetical protein PP1665 NM_030792.4 2.48 0.00

Supplementary Tab. 2b

Fold Gene name Gene symbol Accession no. SD change Structural Coronin, actin binding protein, 2A CORO2A NM_052820.2 -2.89 0.53 Connective tissue growth factor CTGF NM_001901.1 -2.63 0.72 Enah/Vasp-like EVL NM_016337.1 -2.46 0.67 Fibronectin 1 transcript variant 1 FN1 NM_002026.1 -3.41 0.86 Gelsolin (amyloidosis, Finnish type) GSN NM_198252.1 -2.62 1.03 Keratin 13 KRT13 NM_002274.2 -6.28 0.46 Myofibrillogenesis regulator 1 MR-1 NM_022572.2 -2.43 0.13 Peanut-like 1 (Drosophila) PNUTL1 NM_002688.2 -2.87 0.21 Thymosin-like 2 TMSL2 NM_182793.1 -3.18 0.49 Thymosin-like 6 TMSL6 NM_181428.1 -3.37 1.44 Prostaglandin F2 receptor negative regulator PTGFRN XM_040709.4 -3.11 0.86 Breast cancer membrane protein 11 BCMP11 NM_176813.3 -7.27 2.08 Immunoglobulin superfamily, member 1 IGSF1 NM_001555.2 -2.03 0.05 Regulation of Transcription/Cell cycle Chr. 6 open reading frame 141 C6orf141 NM_153344.1 -2.84 1.07 Chr. 9 open reading frame 45 C9orf45 NM_030814.3 -2.44 0.91 CCAAT/enhancer binding protein CEBPA NM_004364.2 -2.00 0.23 Cbp/p300-interacting transactivator CITED4 NM_133467.2 -3.86 0.97 F-box only protein 27 FBXO27 NM_178820.3 -2.04 0.37 Inhibitor of DNA binding 1 ID1 NM_002165.2 -2.25 0.49 v-Maf musculoaponeurotic fibrosarcoma oncogene MAFB NM_005461.3 -2.33 0.28 homolog B Neuroblastoma, suppression of tumorigenicity 1 NBL1 NM_005380.3 -5.32 0.05 Nuclear pore complex interacting protein NPIP NM_006985.1 -2.02 0.18 REC8-like 1 (yeast) REC8L1 NM_005132.1 -2.00 0.18 Zinc finger protein 342 ZNF342 NM_145288.1 -2.85 0.37 Metabolism Aldo-keto reductase family 1, member C1 AKR1C1 NM_001353.4 -2.82 0.09 Aldo-keto reductase family 1, member C2 AKR1C2 NM_001354.4 -2.36 0.37 Aldo-keto reductase family 1, member C3 AKR1C3 NM_003739.4 -2.84 0.93 Polypeptide UDP-N-acetylgalactosaminyltransferase 4 GALNT4 NM_003774.3 -2.98 0.40 Heparan sulfate (glucosamine) 3-O-Sulfotransferase 3A1 HS3ST3A1 NM_006042.1 -3.34 0.71 6 (neurosin, zyme) KLK6 NM_002774.2 -3.47 0.04 Sideroflexin 2 SFXN2 NM_178858.3 -2.36 0.13 Sialyltransferase 7 B SIAT7B NM_006456.1 -3.75 0.40 Solute carrier family 35, member C1 SLC35C1 NM_018389.3 -2.44 0.51 Solute carrier family 35, member E2 SLC35E2 NM_014854.1 -2.02 0.30 Synaptotagmin-like 4 (granuphilin-a) SYTL4 NM_080737.1 -4.46 0.21 UDP-glucose dehydrogenase UGDH NM_003359.1 -3.18 1.87 Cell Communications (Signaling (S), Cell Death (D), Growth/Proliferation(G/P)): Bone morphogenetic protein 4 (S,D,G/P) BMP4 NM_130851.1 -2.54 0.68 Bone morphogenetic protein 5 (S,D,G/P) BMP5 NM_021073.2 -2.90 0.00 Bone morphogenetic protein 7 (S,D,G/P) BMP7 NM_001719.1 -2.43 0.94 Fibroblast growth factor receptor 3 (S) FGFR3 NM_022965.1 -2.35 0.77 Leucine rich repeat neuronal 4 (G/P) LRRN4 NM_002319.2 -2.63 0.28 Pregnancy-induced growth inhibitor (G/P) OKL38 NM_182981.1 -2.06 0.39 Relaxin 2 (H2) (G/P) RLN2 NM_134441.1 -2.88 0.64 ATP-binding cassette, sub-family C (CFTR/MRP), ABCC3 NM_003786.2 -2.59 0.36 member 3 (S) Interleukin 4 receptor (S) IL4R NM_000418.1 -2.46 0.23 Mucin 1, transmembrane (S,D,G/P) MUC1 NM_182741.1 -2.40 0.47 Oxytocin receptor (S,D,G/P) OXTR NM_000916.3 -3.23 1.27 Heat shock 70kDa protein 2 (G/P) HSPA2 NM_021979.2 -2.67 0.40 Adenylate cyclase 1 (S) ADCY1 NM_021116.1 -5.12 2.43 BCL2/adenovirus E1B 19kD interacting protein like BNIPL NM_138278.1 -2.83 1.48 (G/P) Calmodulin-like 5 (S) CALML5 NM_017422.3 -2.36 0.78 Calcyphosine (S) CAPS NM_080590.1 -2.59 0.56 -related cell adhesion CEACAM6 NM_002483.3 -2.48 0.65 molecule 6 (S) Chloride intracellular channel 3 (S) CLIC3 NM_004669.2 -2.22 0.37 Dishevelled, dsh homolog 3 (S,G/P) DVL3 NM_004423.3 -2.02 0.30 Growth arrest and DNA-damage-inducible, beta (S) GADD45B NM_015675.1 -2.36 0.35 Leucine rich repeat (in FLII) interacting protein 2 (S) LRRFIP2 NM_017724.1 -2.04 0.28 RAP guanine-nucleotide-exchange factor (GEF)-like ( 1 (S RAPGEFL1 NM_016339.1 -3.29 0.15 RAS protein activator like 1 (GAP1 like) (S) RASAL1 NM_004658.1 -2.66 0.34 S100 calcium binding protein P (S) S100P NM_005980.1 -2.49 0.52 Signal peptide, CUB domain, EGF-like 2 (S) SCUBE2 NM_020974.1 -3.66 1.93 Serum/glucocorticoid regulated kinase (S) SGK NM_005627.2 -2.46 0.16 Trefoil factor 3 (intestinal) (S) TFF3 NM_003226.1 -5.19 3.11 Transient receptor potential cation channel, subfamily V, TRPV4 NM_147204.1 -2.50 0.49 member 4 (S) Annexin A8 (S) ANXA8 NM_001630.1 -4.89 1.59 (), beta polypeptide (S) GP1BB NM_000407.3 -3.71 1.05 CD44 antigen (S) CD44 NM_000610.2 -2.82 1.49 Other (Unknown function) Similar to Epithelial membrane protein-2 (EMP-2) LOC376874 XM_352443.1 -2.52 0.02 Similar to RIKEN cDNA 1100001G20 LOC400610 XM_375478.1 -10.32 0.49 PNAS-123 LOC85028 XM_378848.1 -2.06 0.43 Purkinje cell protein 4 PCP4 NM_006198.1 -2.37 0.66 Thioredoxin interacting protein TXNIP NM_006472.1 -3.61 1.52 Williams Beuren syndrome region 20C WBSCR20C NM_149379.1 -2.34 0.06 Williams Beuren syndrome chromosome region 24 WBSCR24 XM_379866.1 -2.08 0.39 Hypothetical proteins Hypothetical protein DKFZP434I2117 NM_031478.3 -3.79 1.40 Hypothetical protein DKFZp434K0410 NM_019085.1 -2.12 0.42 Hypothetical protein FLJ20366 NM_017786.1 -3.37 1.63 Hypothetical protein FLJ32833 NM_152488.1 -2.58 0.80 Hypothetical protein LOC91373 XM_038063.8 -2.75 0.82 Hypothetical protein similar to RNA-binding protein lark MGC10871 NM_031492.2 -2.18 0.35 Hypothetical protein MGC50853 NM_203305.1 -2.35 0.30 Hypothetical protein MGC5178 NM_024044.2 -2.36 0.66