Rabbit Anti-Human EPHB1 (Phospho-Tyr594/604) Polyclonal Antibody (CABT-L3539) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Rabbit Anti-Human EPHB1 (Phospho-Tyr594/604) polyclonal antibody (CABT-L3539) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit Anti-Human HSL (Phospho-Ser552) polyclonal antibody. This antibody detects endogenous levels of EPHB1/2 only when phosphorylated at Tyr594/604.

Specificity Target Modification: Phospho. Modification Sites: Human: Y594/Y596; Mouse: Y594/Y604; Rat: Y594/-

Target Human EPHB1/2 (Phospho-Tyr594/604)

Immunogen The antiserum was produced against synthesized peptide derived from human EPHB1/2 around the phosphorylation site of Tyr594/604. Immunogen range: 561-610

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse, Rat

Purification Affinity Purified

Conjugate Unconjugated

Applications WB, IF, ELISA

Molecular Weight 109 kDa

Preparation The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Format Liquid

Concentration Lot specific

Buffer Rabbit IgG in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.

Preservative 0.02% Sodium Azide

Storage Stable at -20°C for at least 1 year.

Ship Wet ice

Warnings For research use only.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Keywords EPHB1;EPH receptor B1;ELK;NET;Hek6;EPHT2;ephrin type-B receptor 1;EK6;EPH-like kinase 6;eph tyrosine kinase 2;soluble EPHB1 variant 1;tyrosine-protein kinase receptor EPH- 2;neuronally-expressed EPH-related tyrosine kinase;

GENE INFORMATION

Gene Name EPHB1 EPH receptor B1 [ Homo sapiens (human) ]

Official Symbol EPHB1

Synonyms ELK, EPB1, EPHT2, EPTH2, Eph receptor B1, Ephrin type-B receptor 1 precursor, HEK6, NET, Tyrosine-protein kinase receptor EPH-2, kinase EphB1

Entrez Gene ID 2047

UniProt ID P54762

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]