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CURRICULUM VITAE Maggie S. Matern Department Of From Cell Fate to Terminal Differentiation – Insights into Inner Ear Hair Cell Development from Cell Type-Specific Transcriptomic Analyses Item Type dissertation Authors Matern, Maggie S. Publication Date 2019 Abstract Hair cells (HCs), which are specialized neuroepithelial sensory cells of the inner ear, are responsible for conveying information about the environment, such as sound and movement, to the brain. In adult mammals, HCs do not spontaneously regenerate. ... Keywords development; transcriptomics; Gene Expression Profiling; Genetics; Inner Ear; Hair Cells, Auditory, Inner Download date 05/10/2021 08:41:47 Link to Item http://hdl.handle.net/10713/9592 CURRICULUM VITAE Maggie S. Matern Department of Otorhinolaryngology Head and Neck Surgery University of Maryland School of Medicine Department of Otorhinolaryngology Head and Neck Surgery University of Maryland School of Medicine 800 W. Baltimore Street, Room 405 Baltimore, MD 21201 Email: [email protected] EDUCATION 2013-2019 University of Maryland School of Medicine, Baltimore, MD Department of Otorhinolaryngology Head and Neck Surgery Doctor of Philosophy 2009-2013 University of New Hampshire, Durham, NH Bachelor of Sciences, Genetics, Summa Cum Laude EMPLOYMENT HISTORY 2014-2019 Graduate Research Assistant, University of Maryland Baltimore, Maryland, U.S. 2012-2012 Biological Sciences Technician Summer Intern, FDA Center for Veterinary Medicine, Laurel, Maryland, U.S. 2011-2011 Intern, Lonza Biologics, Portsmouth, New Hampshire, U.S. 2010-2013 Employee, Families First Health and Support Center, Portsmouth, New Hampshire, U.S. RESEARCH GRANTS NIH/NIDCD F31 DC016218, $93,133.00 July 1 st , 2017 – May10 th , 2019 To be or not to be – GFI1 as a Critical Factor in Hair Cell Fate and Survival Principal investigator: Maggie S. Matern University of Maryland School of Medicine NIH/NIDCD T32 DC00046, $77,608.00 July 1 st , 2015 – June 30 th , 2017 Center for Comparative and Evolutionary Biology of Hearing (C-CEBH) Pre-Doctoral Training Grant University of Maryland, College Park HONORS AND AWARDS 2018 Department of Otorhinolaryngology – Head and Neck Surgery Research Award 2018 Langenberg Endowment in Women's Health and Epidemiology Award 2018 National Cancer Institute Scholarship for Cold Spring Harbor Laboratory courses 2018 Association for Research in Otolaryngology Graduate Student Travel Award 2017 39th Annual UMB Graduate Research Conference Outstanding Presentation Award 2016 38th Annual UMB Graduate Research Conference Outstanding Presentation Award 2016 Association for Research in Otolaryngology Graduate Student Travel Award 2012 Alpha Phi Omega Service Fraternity Distinguished Service Key 2010-2013 University of New Hampshire University Honor’s Program 2010 Dr. Lorus and Marjorie Milne Scholarship for Students in the Biological Studies TEACHING SERVICES 2016-2017 Teaching Assistant, Introduction to Human Genetics I, fall 2016 and fall 2017 2015 Tutor, Baltimore City Community College (BCCC) 2011-2012 Study Skills Tutor, General Biology at the University of New Hampshire PROFESSIONAL SOCIETY MEMBERSHIPS 2016-Present Member of the Association for Research in Otolaryngology (ARO) 2015-2016 Member of the American Society of Human Genetics (ASHG) UNIVERSITY AND COMMUNITY SERVICE 2018 Student Panel Volunteer, Graduate Program in Life Sciences new student orientation 2018-Present Volunteer at the University of Maryland Medical Center Neonatal Intensive Care Unit (NICU) 2015-Present Special Volunteer at the National Institute of Health, National Institute on Deafness and Other Communication Disorders 2016 Ethics Discussion Leader, Graduate Program in Life Sciences new student orientation 2015-2016 Student Representative on the Epidemiology and Human Genetics Graduate Program Committee 2011-2013 Member of Alpha Phi Omega Theta Zeta: UNH’s National Service Fraternity 2010 Contributor to a Fosmid Analysis of the Strawberry Genome RELEVANT COURSEWORK Professional Courses: 2018 Chromatin, Epigenetics & Gene Expression, Cold Spring Harbor Laboratory (CSHL) 2017 Biology of the Inner Ear, Woods Hole Marine Biological Laboratories (MBL) 2015 Introduction to Genomics and Bioinformatics Workshop, Institute for Genome Sciences University of Maryland, College Park: 2016-2017 Special Topics in Neuroscience: Hearing I&II University of Maryland School of Medicine: 2013-2019 Mechanisms in Biomedical Science, Human Genetics I&II, Genomics and Bioinformatics, Programming for Bioinformatics, Genomics of Model Species, Biostatistical Methods University of New Hampshire: 2009-2013 Genetics, Human Genetics, Microbiology, Eukaryotic Cell & Developmental Biology, Psychobiology, Biochemistry, Organic Chemistry, Physics, Molecular Genetics, Molecular Microbiology, Molecular Evolution PRESENTATIONS Oral: 1. Matern, M. (2018) Ikzf2 /helios Mediated Transcriptional Control of Outer Hair Cell Functional Maturation. University of Maryland School of Medicine ENT Department Annual Blanchard / Kleiman Resident Research Day, June 3 rd , 2017, Baltimore MD. 2. Matern, M. (2018) Helios – Shining a Light on Outer Hair Cell Functional Maturation via a Multi-Omic Approach. Association for Research in Otolaryngology (ARO) 2018 Midwinter Meeting, February 10 th , 2018, San Diego, CA. 3. Matern, M. (2017) Tapping into the Zebrafish Hair Cell Translatome using RiboTag. 16 th Annual Eastern Auditory Retreat at Georgetown University, June 9th , 2017, Washington, DC. 4. Matern, M. (2017) The HC-Tag zebrafish: A tool for cell-type specific analyses using intact larvae. University of Maryland School of Medicine ENT Department Annual Blanchard / Kleiman Resident Research Day, June 3 rd , 2017, Baltimore MD. 5. Matern, M. (2017) A New Tool for Translatome Analysis of Zebrafish Hair Cells from Intact Larvae. University of Maryland, Baltimore Graduate Research Conference March 13 th , 2017, Baltimore, MD. 6. Matern, M. (2016) Non-hair cell recombination and progressive hearing loss in the heterozygous Gfi1-Cre mouse. C-CEBH/NIDCD Joint Workshop, October 5 th , 2016, College Park, MD. 7. Matern, M. (2016) The Gfi1-Cre mouse: important considerations for hearing research. University of Maryland School of Medicine ENT Department Annual Blanchard / Kleiman Resident Research Day , June 11 th , 2016, Baltimore, MD. 8. Matern, M. (2016) The utility of the Gfi1-Cre mouse in auditory research. Center for Comparative and Evolutionary Biology of Hearing Advisor Meeting, May 5 th , 2016, University of Maryland, College Park, MD. Poster: 1. Matern, M.S., Milon, B., Ogawa, Y., Tkaczuk, A., McMurray, M., Song, Y., Elkon, R., Hertzano, R. (2019) Reconstructing the transcriptional network downstream of GFI1 in hair cell development. Presented at the Association for Research in Otolaryngology (ARO) 2019 Midwinter Meeting. Baltimore, MD. 2. Matern, M.S. , Beirl, A., Ogawa, Y., Song, Y., Elkon, R., Milon, B., Kindt, K., Hertzano, R. (2017) A New Tool for Translatome Analysis of Zebrafish Hair Cells from Intact Larvae. Presented at the Association for Research in Otolaryngology (ARO) 2017 Midwinter Meeting. Baltimore, MD. 3. Matern, M.S. , Zhang, X., Milon, B., Hertzano, R. (2017) Analysis of the Immune Cell Population of the Neonatal Mouse Inner Ear. Presented at the Association for Research in Otolaryngology (ARO) 2017 Midwinter Meeting. Baltimore, MD. 4. Matern, M.S. , Margulies, Z., Milon, B., Song, Y., Vijayakumar, S., Elkon, R., Jones, S., Hertzano, R. (2016) Hair cell-specific analyses using the Gfi1-Cre mouse. Presented at the Graduate Research Conference at the University of Maryland, Baltimore, Baltimore, MD. 5. Matern, M.S. , Margulies, Z., Milon, B., Song, Y., Vijayakumar, S., Elkon, R., Jones, S., Hertzano, R. (2016) Hair cell-specific analyses using the Gfi1-Cre mouse. Presented at the Association for Research in Otolaryngology (ARO) 2016 Midwinter Meeting. San Diego, CA. 6. Matern, M.S. , Milon, B., Song, Y., Silipino, L., Vijayakumar, S., Elkon, R., Jones, S., Hertzano, R. (2015) Broad Cre mediated recombination in the Gfi1-Cre mouse inner ear. Presented at the American Society of Human Genetics (ASHG) 2015 Annual Meeting. Baltimore, MD. PEER REVIEWED PUBLICATIONS 1. Matern, M.S., Milon, B., Ogawa, Y., Tkaczuk, A., Song, Y., Elkon, R., Hertzano, R. GFI1 functions to repress neuronal gene expression in developing hair cells. In preparation. 2. Nesmith, J.E., Hostelley, T.L., Leitch, C.C., Matern, M.S. , Sethna, S., McFarland, R., Lodh, S., Westlake, C., Hertzano, R., Ahmed, Z.M., Zaghloul, N. Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provide insight into metabolic phenotypes. (2019). Human Molecular Genetics , ddz053, https://doi.org/10.1093/hmg/ddz053. 3. Chessum, L.*, Matern, M.S. *, Kelly, M.C., Johnson, S.L., Ogawa, Y., Milon, B., McMurray, M., Driver, E.C., Parker, A., Song, Y., Codner, G., Esapa, C.T., Prescott, J., Trent, G., Wells, S., Dragich, A.K., Frolenkov, G.I., Kelley, M.W., Marcotti, W., Brown, S.D.M., Elkon, R., Bowl, M.R., Hertzano, R. Helios is a key transcriptional regulator of outer hair cell maturation. (2018). Nature , 563, 696-700. *Co-first authors 4. Matern, M.S., Beirl, A., Ogawa, Y., Song, Y., Paladugu, N., Kindt, K., Hertzano, R. Transcriptomic profiling of zebrafish hair cells using RiboTag. (2018). Frontiers in Cell and Developmental Biology. doi:10.3389/fcell.2018.00047 5. Matern, M., Vijayakumar, S., Margulies, Z., Milon, B., Song, Y., Elkon, R., Zhang, X., Jones, S.M., Hertzano, R. (2017). Gfi1 Cre mice have early onset progressive hearing loss and induce recombination
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