MEDICAL DEVICE PIPELINE
SURGICAL ROBOTICS GI/ENDOSCOPY DEVICES BIOMEDICAL PHOTONICS NEUROSURGERY DEVICES CARDIOVASCULAR DEVICES HEALTH CARE ACCESSORY DEVICES BIOMEDICAL RESEARCH/DIAGNOSTIC DEVICES REHABILITATION TECHNOLOGIES IMAGE-GUIDED SURGERY SURGICAL TOOLS CATHETERS Who we are
The Center for Technology Transfer and Commercialization (CTTC) provides professional technology commercialization services to the Vanderbilt community, so that we may optimize the flow of innovation to the marketplace and generate revenue that supports future research activities.
CTTC accomplishes this by serving as an efficient and effective conduit for the transfer of promising Vanderbilt intellectual property to industry; contributing to regional economic development by licensing locally and supporting new venture creation; and encouraging collaboration between academia and industry.
Industry Collaboration
Key to carrying out the mission of CTTC is the ability to form collaborative and professional relationships with companies in a variety of industries including space exploration, education, pharmaceuticals, healthcare/patient care, robotics, energy, environmental preservation, engineering, and many more. CTTC does this through: • Strategic Negotiation - Timely transactions are as critical for us as they are for our industry partners. We pay careful attention to negotiation timelines and work to ensure high levels of responsiveness and rapid closing of negotiations • Reasonable Diligence - Licenses must include reasonable diligence provisions to ensure that products based on Vanderbilt technology are developed and commercialized in a timely fashion for our benefit and the benefit of the public. • Societal Benefit - Our motivations for commercializations are deeply rooted in benefiting individuals and patients on a global scale. • Protection leads to Commercialization - CTTC views IP protection as a means to an end. The real focus is on commercialization of technologies. • Focused on Transactions - CTTC’s experienced team of licensing professionals are highly transactionally focused. • Collaborative Research - CTTC highly encourages industry collaboration, either along with a license or as a precursor. • Quality Driven - High quality contracts lay the foundation for strong and lasting partnerships. Repeat business is important to us. MEDICAL DEVICE PIPELINE
Table of Contents
Vanderbilt Medical Device Core Research Capabilites...... 3 Image Guided Surgery...... 4 Surgical Robotics...... 5 Surgical Tools...... 6 Catheters...... 7 Rehabilitation Technologies...... 7 GI/Endoscopy Devices...... 8 Cardiovascular Devices...... 9 2 Neurosurgery Devices...... 10 Health Care Accessory Devices...... 11 Biomedical Photonics...... 12 Biomedical Research/Diagnostic Devices...... 13 The Medical Device Pipeline highlights Vanderbilt’s current collection of technologies that are the product of the university’s commitment to collaborative, applied research in the fields of engineering and medicine. Vanderbilt has a number of Centers, Departments and Institutions that are paving the way for engineers and clinicians to work together to find innovative solutions to the world’s health problems.
Vanderbilt University completed construction of a 230,000-square-foot Engineering and Science Building that fosters project teamwork and offers programs, instrumentation areas and core research space that promotes interdisciplinary work, particularly in engineering and related fields. Rendering courtesty of: Wilson Core Research Architects/Vanderbilt University. Capabilities
Institute in Surgery and Engineering (VISE) ViSE is an interdisciplinary, trans-institutional center focused on the creation, development, implementation, clinical evaluation and commercialization of methods, devices, algorithms, and systems designed to facilitate interventional processes and their outcome. Areas of focus include: image-guided surgery; intelligent, flexible robotic manipulation; ultrasound guidance for surgical interventions; steerable needles; wireless capsule robotics, etc. Center for Rehabilitation Engineering and Assistive Technology (CREATE) Institute of Imaging Science (VUIIS) CREATE focuses on restoring health, mobility, independence and societal participation to individuals with disabilities by designing, developing and VUIIS operates state-of-the-art facilities for imaging research at all scales controlling next-generation assistive and rehabilitative technologies, including imaging animals and human subjects. Areas of focus include: such as prosthetic limbs and robotic exoskeletons. The Center is led by cancer, neurological disorders, metabolic disorders, cardiovascular Drs. Michael Goldfarb and Karl Zelik and consists of a state-of-the-art disease, and others. 3000 sq. ft. motion analysis lab for human subject experiments, plus about 3000 sq. ft. of engineering and fabrication space. Institute for Integrative Biosystems Research and Education (VIIBRE) Biophotonics Center VIIBRE invents the tools and develops the skills that are required to The Biophotonics Center is a trans-institutional initiative that focuses on conduct research in systems biology. Areas of focus include: cellular the development and application of photoic technologies for fundamental biosensors, bioprocess controllers, mathematical models for wound discovery and clinical translation in biomedicine. Areas of focus include: healing and cancer, infectious disease detection, biomedical imaging, cancer photonics, neuro-photonics, and multiscale photonics. and cellular/tissue engineering.
Institute of Nanoscale Science and Engineering Clinical Translational Science Award (CTSA) (VINSE) The Clinical and Translational Science Award (CTSA) grant, the largest single government research grant in Vanderbilt’s history, is aimed at VINSE is focused on new science and technology based on nanoscale expediting the translation of laboratory discoveries to patients in the materials. Researchers team locally and globally, providing an community. The grant helps fund the Vanderbilt Institute for Clinical and environment where physicists, chemists, biologists, and engineers Translational Research (VICTR), which provides access to resources, may collaboratively solve forefront problems and create new scientific training and collaboration, and informatics and biostatistical systems understanding. Areas of focus include: nanobio, nanoscale electronics to support translation of fundamental science discoveries into clinical and optics, nanoscience theory, nanotechnology and new materials. practice.
Department of Biomedical Informatics (DBMI) Medical Products Support Services (MPSS) Vanderbilt’s DBMI is the largest academic department of biomedical Vanderbilt’s Medical Products Support Services (MPSS), supports informatics in the country, with more than 65 faculty members. Areas of investigators who are involved with Food and Drug Administration (FDA) focus include: computer science, information science, cognitive science, regulated device research. It provides a list of services including early social science, engineering, and clinical and basic biological sciences. device development guidance, regulatory guidance, Investigation Device Exemptions support, and more. Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Image Guided Surgery Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Konrad Surgical Planning and Navigation Software for Portfolio of Dawant Deep Brain Stimulation (Portfolio) Multiple Patents
Labadie System and Methods of Using Image Guidance Issued US Fitzpatrick for Placement of Cochlear Stimulator Devices 8380288
Image Guided Navigation System for Issued US Galloway Endoscopic Eye Surgery 8403828
Laser Range Scanning for Cortical Surface Issued US Miga 7103399 and Registration & Deformation Tracking 7647087
Brain Shift Compensation Using Computer Issued US Miga Models 7072705
Model-Based Compression Correction Issued US Miga Framework for Ultrasound 9782152
A Local Stylus and/or Image Transformation Portfolio of Multiple Patents Miga Device to Correct Data for Deformations in in US, EPO, DE, Image-Guided Procedures JP
Image Guidance System for Breast Cancer Issued US Miga Surgeries 10426556
Therapeutic Guidance Compute Node Miga Patent Pending Controller
A Novel Trackerless Image Guided Soft Tissue Published US Miga Surgical Design for Use with Surgical 20170143430A1 Microscopes or Similar Technologies
Seeking Partners Partnered
4 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Surgical Robotics Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Portfolio of Simaan Insertable Robotic Effector Platform Portfolio Multiple Patents & Copyrights
Webster Precision Pneumatic Robot for MRI-Guided Issued US 9492234 and Barth Neurosurgery 10321963
Steerable Needles: A Better Turning Radius Published US Webster with Less Tissue Damage 20140276586A1
Minimallly Invasive Robotic Platform for Issued US Simaan Transurethral Exploration and Intervention 9956042
Issued US Low Cost Dexterous Wrists for Surgical 9687303 Simaan Intervention Published US 20170265950A1
Methods for Quick and Safe Deep Access into Issued US Simaan Mammalian Anatomy 9549720
Algorithms for Compliant Insertion and Motion Issued US Simaan 9539726 and Control of Continuum Robots 10300599
Algorithms for Contact Detection and Contact Issued US Simaan Localization in Continuum Robots 9333650
Wireless Tissue Palpation for Minimally Issued US Valdastri Invasive Robotic Surgery Techniques 9826904
Algorithms and Methods for Motion and Force Simaan Copyrights Control of Continuum Robots
Published US Webster Flexible Instrument with Precurved Elements 20160016319A1
A Robotic System for Treating Intracranial Published US Webster Hemorrhage (ICH) 20150223832A1
Seeking Partners Partnered
5 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Surgical Robotics (continued) Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Published PCT Simaan Continuum Robots for Micro-Scale Motion WO2019055701
A Tip for Surgical Devices with Arc Length Published US Webster Varying Curvature 20190083749A1
Hand-Held Concentric Tube Manipulator Portfolio of Webster Actuation Unit and Mechanism for Surgery Patents
Modular, Sterilizable Robotic System for Issued US Webster Endonasal Surgery 10307214
Published US 20190015166A1 Webster Snared-Tool Robotic Surgery System Published EPO 3399938
A System for Transoral Targeting of Suspicious Published US Webster Nodules in the Body 20180214010A1
Basic Technology Technology Feasibility IP Status Non-Robotic Surgical Tools Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Issued US MAESTRO: Non-Robotic Dexterous Laproscopic 9901412 Webster Instrument with a Wrist providing Seven 10149694 Multiple Pending Degrees of Freedom (Portfolio) US Applications
Langerman Wearable Surgical Camera Patent Pending
Portfolio of Geiger SureTight: GI Anastamosis Leak Detection Patents
Seeking Partners Partnered
6 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Catheters Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Point of Care Device for Confirmation of IV Portfolio of Eagle Catheter Placement & Measurement of Venous Patents Pressures
Catheter Having Temperature Controlled Issued US Merryman Anchor and Related Methods 9259261
Cryo Sheath Anchoring for Precision Cardiac Merryman Patent Pending Ablation
Singleton Peripheral Nerve Catheter Advancer Patent Pending
Nicholson Track-Star Angiographic Catheter Patent Pending
Basic Technology Technology Feasibility IP Status Rehabilitation Technologies Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Vanderbilt Exoskeleton: Powered Lower-Limb Portfolio of Goldfarb Exoskeleton for Paraplegia Multiple Patents
Powered Robotic Knee and Ankle Prosthesis for Portfolio of Goldfarb Transfemoral Amputees Multiple Patents
Vanderbilt Multigrasp Myoelectric Prosthetic Portfolio of Goldfarb Hand Multiple Patents
IntelliCane: Instrumented cane for diagnosis Published US Sarkar and evaluation of gait behavior in individuals 20160262661A1 with mobility issues
Wearable Exoskeleton for Reducing Low Back Portfolio of Zelik Loading Pending Patents
Wearable Device to Monitor Musculoskeletal Zelik Patent Pending Loading & Prevent Injuries
Seeking Partners Partnered
7 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status GI/Endoscopy Devices Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Device for Detecting and Measuring Conditions Portfolio of Vaezi of Esophageal Mucosa Patents
Local Magnetic Actuation for Minimally Issued US Valdastri Invasive Surgery 9737364
Wireless Tissue Palpation for Minimally Issued US Valdastri Invasive Robotic Surgery Techniques 9826904
Real-time Pose and Magnetic Force Detection Published US Valdastri for a Wireless Magnetic Capsule 20150342501A1
Robotic Control System for Magnetically Published US Valdastri Actuated Capsule Endoscopes 20190104994A1
Issued US Valdastri Robotic Platform for Mini-Invasive Surgery 9579163
Hydro-Jet Endoscopic Capsule for Gastric Published US Valdastri Cancer Screening in Low Resource Settings 20170245741A1
Portfolio of Valdastri Disposable Endoscope Pending Patents
Wireless Tablet App for Remote Collaboration Obstein Copyrights and Training in Colonoscopy
Seeking Partners Partnered
8 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Cardiovascular Devices Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Point of Care Device for Confirmation of IV Portfolio of Eagle Catheter Placement & Measurement of Venous Patents Pressures
Portfolio of Brophy Autologous Vein Harvest Kit Patents
An Adaptive Clutter Demodulation Scheme for Published US Byram Measuring Low Velocity Blood using Ultrasound 20170135675A1
Catheter Having Temperature Controlled Issued US Merryman Anchor and Related Methods 9259261
Shape Memory External Stents for Vascular Portfolio of Sung Applications Pending Patents
Comparison of Peripheral and Central Eagle Patent Pending Intravenous Analysis to Echocardiography
Rohde Intraoperative Vessel Sizer Patent Pending
Nicholson Patent Ductus Stent Patent Pending
Nicholson Track-Star Angiographic Catheter Patent Pending
Seeking Partners Partnered
9 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Neurosurgery Devices Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
System and Methods for Determining Portfolio of Fitzpatrick Orientation of Bone Implanted Post for Patents Cochlear and Deep Brain Stimulation
Webster Precision Pneumatic Robot for MRI-Guided Issued US 9492234 Barth Neurosurgery 10321963
System and Methods of Using Image-guidance Labadie Issued US Fitzpatrick for Placement of Cochlear Stimulator Devices 8380288 and Drug Carrier Devices
Electrical Impedance Method for Cochlear Webster Patent Pending Implant Localization
PosiSeat™: Assured Seating of Threaded Issued US Fitzpatrick Surgical Components 8231636
Thomas Dense-Packed Probe Positioning Drive Patent Pending
Kao Konrad Adjustable Universal Platform for Surgical Issued US Fitzptrick Navigation, Approach, and Implantation 8414597 Labadie
Seeking Partners Partnered
10 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Health Care Accessory Devices Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Maximum Barrier Sterile Drape for Neck and Issued US Bream Upper Chest 8826912
Automated Abdominal Binder for Treatment of Issued US Baudenbacher Orthostatic Hypotension 10179083
Issued US Schlesinger DynoAlarm: Smart Patient Monitoring Alarm 9870678
Frequency-Selective Silencing Device for Digital Published US Schlesinger Filtering of Audible Medical Alarm Sounds to 20180376237A1 Enhance ICU Patient Recovery
A Hand Held Device for Quantitative Published US Byram Assessment of Tissue Stiffness 20160367220A1
Portable Flow Phantom for Doppler Ultrasound Issued US Grice Quality Measurements 10085725
Makhoul Pitting Edema Testing Device Patent Pending
Single-handed Side-loading Guidewire Torque Issued US Nichols Device for Interventional Medical Procedures 10076640
Seeking Partners Partnered
11 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Biomedical Photonics Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Near Infrared Fluorescence for Parathyroid Portfolio of Mahadevan-Jansen Identification (Portfolio) Multiple Patents
Issued US Breast Tumor Margin Detection System Using 9020581, Mahadevan-Jansen 9020581, Spatially Offset Raman Spectroscopy 9824440, and 10325366
Issued US Miniature Optical Coherence Tomography 8655431, Joos Probe for Real-time Monitoring of Surgery 9014788, and 9757038
Jansen Systems and Methods for Optical Stimulation Portfolio of Mahadevan-Jansen of Neural Tissues (Portfolio) Patents
Issued US Non-Invasive Skin Cancer Detection using 7508524, Mahadevan-Jansen Raman Spectroscopy-OCT System 8300220, and 8553219
Porous Silicon Membrane Biosensors for High Issued US Weiss Sensitivity Detection of Low Molecular Weight 8506887 and Biological or Chemical Targets 8920729
Functionalized Optical Sensors Comprising Issued US Weiss Diffraction Gratings on Porous Silicon 8349617 Structures
Polarized Diffuse Reflectance Spectroscopy for Mahadevan-Jansen Patent Pending Intraoperative Nerve Visualization
Non-Invasive, Real-Time Bacterial Identification Mahadevan-Jansen Patent Pending for Middle Ear Infections
Low-Level Light Therapy Device for Treating Published US Hicks Diabetic Foot Ulcers 20180304094A1
Seeking Partners Partnered
12 Vanderbilt University Medical Device Pipeline
Basic Technology Technology Feasibility IP Status Biomedical Research/Diagnostic Devices Research Development Demonstration
Discovery Invention Lab Animal Type/ Lead Clinical Regulatory and and prototype model Status/ Inventor Technology trials process ideation prototyping validation validation Serial #
Rotary planar peristaltic micropump (RPPM) Portfolio of Wikswo and Rotary Planar Valve (RPV) for microfluidic Patents systems
Published US 20150079583A1 Baudenbacher Thermal ELISA Published PCT WO2015027151
Easy-to-Fabricate, Cost-Effective, and Stable Issued US Weiss Surface Enhanced Raman Scattering (SERS) 9593981 substrates
Issued US Weiss Porous Silicon Membrane Waveguide Biosensor 8506887 and 8920729
Extractionator: Low Resource Extraction and Issued US Haselton Processing of Biological Samples Using Surface 9677979 and Tension Valves 9869675
Marasco Wearable Metabolic Rate Sensor Patent Pending
Manning Device for Radiopharmaceutical Production Patent Pending
Point of Care Rheological Flow Assay for Portfolio of Cyr Diagnosis and Monitoring of Disease Pending Patents
Seeking Partners Partnered
13 Vanderbilt Research Quick Facts • Vanderbilt University is ranked 10th most innovative university in the world.
• Vanderbilt University is ranked 14th among the best national universities.
• Vanderbilt sponsored research and project awards total $739 million in FY18.
• Vanderbilt University School of Medicine Ranks 16th among the top medical schools for research and ranks 8th in NIH funding.
• Vanderbilt is home to one of the oldest biomedical engineering departments in the country, dating back to 1968.
The close proximity of the Vanderbilt School of Engineering and Vanderbilt University Medical Center enables a culture of interdisciplinary collaboration in research and education. The recent addition of the Engineering and Science building in 2016 brings further opportunity for collaboration with seven floors of state-of-the-art research spaces and an innovation center called the Wond’ry. For licensing inquiries please contact:
Chris Harris Ashok Choudhury Taylor Jordan Masood Machingal Philip Swaney [email protected] [email protected] [email protected] [email protected] [email protected] 615.343.4433 615.322.2503 615.936.7505 615.343.3548 615.322.1067
Vanderbilt technologies available for licensing and collaboration: www.Vanderbilt.edu/cttc/technologies View Vanderbilt’s other Technology Pipelines:
https://cttc.co/industry/technology-portfolios