11th European Regional Conference on Thoracic Oncology: Where We Are Now? An initiative of the Chinese – European Alliance of Oncology in collaboration with National Cancer Institute (Lithuania), University, Lithuanian Society of Oncology, Medical University of Bialystok, Euroregional Medical Centre for Research and Education, Mannheim University, Lithuanian Society of Pulmonology and IASLC

th 13-15 of June 2019 “Radisson Blu Hotel Lietuva” (Konstitutcijos Ave. 20), Vilnius, Lithuania

SCIENTIFIC PROGRAMME

Thursday, 13 June 2019

17:00-18:30 Young Investigators Session Chairs: Miroslaw Kozlowski (Bialystok, Poland), Saulius Cicenas (Vilnius, Lithuania) 17:00-17:15 Potential role of microRNAs in diagnosis and therapy Joanna Kisluk of non-small cel lung cancer Bialystok, Poland

17:15-17:30 Emerging role of long noncoding RNAs in non-small Oksana Kowalczuk cel lung cancer: current status and future Bialystok, Polad perspectives. 17:30-17:45 Protozoa infection in lung cancer patients Ryte Rynkeviciene Vilnius, Lithuania

17:45-18:00 Combination of model systems and patient samples Julija Simiene for the investigation of lung cancer biomarkers Vilnius, Lithuania

18:00-18:30 Let's Make a Poster! Rossitza Krasteva , Discussion

19:00-22:30 Faculty dinner (restaurant „Skybar“ 22nd floor, hotel Radisson BLU Hotel Lietuva, Konstitucijos Ave. 20)

Friday 14 June 2019

, 07:00-08:00 Registration

08:00-08:45 Welcome address Moderation: Christian Manegold (Mannheim, Germany), Jacek Niklinski (Bialystok, Poland), Saulius Cicenas (Vilnius, Lithuania)

1. Lithuanian Minister of Health 2. Rector of Vilnius University 3. Dean of the Faculty of Medicine 4. President of Lithuanian Cancer Patients Coalition „POLA“

Patient’s Story 08:45-09:15 Epidemiology/Lung Cancer Screening/ Chairs: Ningfei Jl (Jiangsu, ), Lothar Richard Pilz (Mannheim, Germany)

08:45-09:00 Key statistics in lung cancer epidemiology Lothar Richard Pilz Mannheim, Germany

09:00-09:15 Lung cancer screening – challenges and unsolved Wieland Voigt issues Erlangen, Germany

9:15-10:00 Pathology/ Molecular Diagnostics Chairs: Kestutis Suziedelis (Vilnius, Lithuania), Wieland Voigt (Erlangen, China) 09:15-09:30 Non small cell lung carcinoma: pathology and Mauro Papotti molecular diagnostics Torino,

09:30-09:45 Gene editing in lung cancer Damian Mojsak Bialystok, Poland

09:45-10:00 Molecular tools for lung cancer diagnosis Kestutis Suziedelis Vilnius, Lithuania

10:00-10:45 Satellite AstraZeneca Chair: Saulius Cicenas (Vilnius, Lithuania)

The role of Tagrisso in non-small-cell lung cancer Alvydas Cesas treatment Klaipeda, Lithuania

10:45-11:30 Satellite Roche Chair: Saulius Cicenas (Vilnius, Lithuania)

PD-L1 inhibitors in advanced NSCLC: from 2nd Line to Vaida Gedvilaite frontline therapy Vilnius, Lithuania

11:30-12:00 Coffee break

12:00-13:00 Surgery for Lung Cancer Chairs: Miroslaw Kozlowski (Bialystok, Poland), Tomasz Grodzki (Szczecin, Poland) 12:00-12:15 Surgical management for advanced Guibin QIAO NSCLC patients Guangdong, China

12:15-12:30 Regional analgesia in management of post- Tomasz Grodzki thoracotomy pain relief Szczecin, Poland 12:30-12:45 VAMLA in staging of lung cancer Michal Wilkojc Zakopane, Poland

12:45-13:00 Uniportal VATS in lung cancer Miroslaw Kozlowski Bialystok, Poland

13:00-14:00 Lunch

14:00-14:30 Medical Management of Lung Cancer Part 1 Chairs: Robert Pirker (, Austria), Edvardas Danila (Vilnius, Lithuania)

14:00-14:15 Treatment of early stage NSCLC Sigitas Zaremba Vilnius, Lithuania

14:15-14:30 Adjuvant therapy of resected non-small cell lung Robert Pirker cancer: current status & perspectives Vienna, Austria

14:30-15:15 Satellite MSD (Merck Sharp & Dohme) Chair: Saulius Cicenas (Vilnius, Lithuania)

The importance of immunotherapy in treatment-naïve Maximilian Hochmair metastatic NSCLC: Optimizing survival and response Vienna, Austria

15:15-15:45 Medical Management of Lung Cancer Part 2 Chair: Rolandas Zablockis (Vilnius, Lithuania), Ewa Sierko (Bialystok, Poland)

15:15-15:30 Lung cancer chemotherapy: past, present and future Laura Norkiene Vilnius, Lithuania

15:30-15:45 Radiotherapy and radiochemotherapy in non-small- Ewa Sierko cell lung cancer patients Bialystok, Poland

15:45-16:30 Satellite Bristol-Myers Squibb Chair: Alvydas Cesas (Klaipeda, Lithuania)

Role of immunotherapy in lung cancer Vincas Urbonas Vilnius, Lithuania Case report Rugile Cesaite Klaipeda, Lithuania

16:30-17:15 Satellite Boehringer-Ingelheim Chair: Skaidrius Miliauskas (Kaunas, Lithuania)

Marius Zemaitis Impact of Afatinib dose modification on safety and Kaunas, Lithuania effectiveness in patients with EGFR mutation-positive advanced NSCLC: Results from a global real-world study (RealGiDo)

17:15-17:45 Coffee break

17:45-19:15 Immuno-oncology and TKI inhibitors in Lung Cancer Chairs: Christian Manegold (Mannheim, Germany), Lucio Crino (Perugia, Italy)

17:45-18:00 The value of the biomarker PD-L1 IHC in predicting Lothar Richard Pilz checkpoint inhibitors efficiency in NSCLC: remarks Mannheim, Germany from a medical statistician

18:00-18:15 Deep sequencing of the T-cell receptors for Yong FANG monitoring peripheral CD8+ T cells in advanced Zhejiang, China NSCLC Chinese patients treated with anti-PD-L1 antibody 18:15-18:30 Medical anti-angiogenesis for non-small cell lung Christian Manegold cancer (NSCLC) in times of targeted therapy and Mannheim, Germany checkpoint- inhibitors 18:30-18:45 Checkpoint inhibitors for early and locally advanced Sofia Baka NSCLC ,

18:45-19:00 How to optimal sequence ALK inhibitors in NSCLC Lucio Crino Perugia, Italy

19:00-19:15 The significance of rebiopsy From first-generation Ningfei JI EGFR-TKI Resistance Jiangsu, China

19:15-19:30 Treatment of Pleural Mesothelioma Chair: Rolandas Zablockis (Vilnius, Lithuania)

19:15-19:30 Novel approaches in the medical treatment of Jan van Meerbeeck malignant pleural mesothelioma (MPM) Rotterdam,

20:00 Dinner (restaurant „Riverside“, ground floor, hotel Radisson Blu Hotel Lietuva, Konstitucijos Ave. 20)

Saturday, 15 June 2019

09:00-10:15 Miscellaneous and Selected Case Reports Chairs: Saulius Cicenas (Vilnius, Lithuania), Mikhail V. Burmistrov (Kazan, ), Guibin QIAO (Guangdong, China)

09:00-09:15 Familial lung cancer in Yunnan-Guizhou plateau of Ying CHEN China Yunnan, China

09:15-09:30 Features of hereditary mutations in the DNA repair Mikhail V. Burmistrov system in patients with esophageal cancer (M.G.Gordiev, M.V.Aglullina, R.F. Yenikeev) Kazan, Russia

09:30-09:45 A case of complex cancer treatment of intrathoracic M.V.Aglullina esophagus after endoscopic tumor perforation and (M.V.Burmistrov, pleural empyema V.Yu. Matveev, O.V.Morov) Kazan, Russia

09:45-10:00 Laryngo-pharyngo-ezofagectomy as a component of Andrey Rudyk combined treatment of locally advanced cancer of the E.Sigal, M.V.Burmistrov, cervical esophagus. T.Sharapov, R.Hamidullin Kazan, Russia

10:00-10:30 Coffee break

10:30-11:15 Selected Case Reports Chairs: Saulius Cicenas (Vilnius, Lithuania), Mikhail V. Burmistrov (Kazan, Russia) 10:30-10:45 A Case report Vaida Gedvilaite Vilnius, Lithuania

10:45-11:00 A Case report Rugile Cesaite Klaipeda, Lithuania

11:00-11:15 A Case report Rasa Venclovaite Klaipeda, Lithuania

11:15 Closing remarks Moderation: Saulius Cicenas (Vilnius, Lithuania), Jacek Niklinski (Bialystok, Poland), Christian Manegold (Mannheim, Germany)