Associations Between Sexual Risk Behaviours, and Certain Beliefs and Perceptions About Antiretroviral Therapy in Botswana
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HARNESSING HIV and SYPHILIS NETWORKS to REDUCE HIV TRANSMISSION in NORTH CAROLINA Rachael Marie Billock a Dissertation Submitted
HARNESSING HIV AND SYPHILIS NETWORKS TO REDUCE HIV TRANSMISSION IN NORTH CAROLINA Rachael Marie Billock A dissertation submitted to the faculty at the University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology in the Gillings School of Global Public Health. Chapel Hill 2020 Approved by: Kimberly A. Powers Jennifer L. Lund Peter J. Mucha Brian W. Pence Erika Samoff © 2020 Rachael Marie Billock ALL RIGHTS RESERVED ii ABSTRACT Rachael Marie Billock: Harnessing HIV and Syphilis Networks to Reduce HIV Transmission in North Carolina (Under the direction of Kimberly Powers) Sexual contact networks containing persons diagnosed with HIV and/or syphilis are efficient platforms for delivery of enhanced HIV treatment support to persons living with HIV (PLWH) and prevention resources to HIV-negative persons. We conducted three inter-related studies among men who have sex with men (MSM) in North Carolina (NC) to assess the potential for network-based interventions to reduce HIV transmission. We first generated independent and combined HIV and syphilis networks using contact tracing data for all MSM diagnosed with HIV or syphilis 2015-2017 in NC. We identified network communities, or clusters of densely connected nodes, in the combined network and evaluated interconnectivity between the syphilis and HIV networks by community. Heightened interconnectivity was associated with younger median age; higher proportions of persons self- identifying as Black, non-Hispanic; and higher proportions of syphilis cases diagnosed at sexually transmitted disease clinics. Next, we used NC surveillance data to identify two types of qualifying “network events” among MSM in NC 01/2013-06/2017: being diagnosed with early syphilis or being named as a recent sexual contact of a person diagnosed with HIV or early syphilis. -
Curriculum Vitae
CURRICULUM VITAE William C. Miller Education 1997 MPH Dept. of Epidemiology, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 1989 PhD Dept. of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 1985 MD The Johns Hopkins University School of Medicine, Baltimore, MD 1981 AB Dept. of Psychology, Princeton University, Princeton, NJ Post-Graduate Training 1995 - 1997 Robert Wood Johnson Clinical Scholar, University of North Carolina at Chapel Hill, Chapel Hill, NC 1991 -1994 Fellow, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC 1991 -1992 Fellow in International Health, Department of Medicine, Muhimbili Medical Center, Dar es Salaam, Tanzania and Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC 1989 -1991 Resident in Medicine, Department of Medicine, The University of Maryland and Baltimore Veterans Administration Hospitals, Baltimore, MD 1988 -1989 Intern in Medicine, Department of Medicine, The University of Maryland and Baltimore Veterans Administration Hospitals, Baltimore, MD 1986 -1988 Postdoctoral Fellow, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 1985 -1986 Postdoctoral Fellow, Interdisciplinary Training Program, Departments of Neuroscience and Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD Professional Positions 2014 - present Professor, Division of Infectious Diseases, Department of Medicine, -
Final Project
IDST 290.002: Data Science for COVID-19 Fall Semester 2020 Faculty Coordinators Jan Hannig Richard Smith Serhan Ziya (email redacted) (email redacted) (email redacted) Course Information Graduate Instructors: Alexander Murph Benjy Leinwand (email redacted) (email redacted) Time // Place: M&W 09:20-10:10 // Remote instruction Important Links: 1. https://sakai.unc.edu ; for course materials and announcements. You should already be added. 2. https://rls.sites.oasis.unc.edu/COVID.html ; for relevant articles and useful links to information about our speakers. 3. (zoom link redacted) 4. https://www.gradescope.com/; we will use this portal for all assignment submissions. More details on how to use this portal are available on our Sakai page under the Resources tab. Entry Code: (redacted) Course Description: The COVID-19 pandemic has stimulated research in many directions. Data scientists have been in- volved in many ways, including mathematical and computational models for the spread of the disease, statistical analyses of data on cases, hospitalizations and deaths, and models for studying such questions as the impact of testing on the efec- tiveness of social distancing. For this COVID Investigations course, we will explore the current research on data science and COVID-19 in a way that is accessible to a wide audience. We will also participate in facilitated classroom discussion and writing to engage with the material and explore ways that a Carolina education might position one to contribute to the ght against the disease. Required Text: None. There will be assigned readings throughout the semester. Attendance of Lectures: Attendance will be based on the Zoom call’s roster and will account for a large portion of your 1 grade. -
Infectivity, Sexual Partnership Patterns, and the Role of Early Infection
HIV TRANSMISSION DYNAMICS: INFECTIVITY, SEXUAL PARTNERSHIP PATTERNS, AND THE ROLE OF EARLY INFECTION Kimberly Anne Powers A dissertation submitted to the faculty of the University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology. Chapel Hill 2010 Approved by: William C. Miller, MD, PhD Myron S. Cohen, MD Azra C. Ghani, PhD Irving F. Hoffman, PA, MPH Audrey E. Pettifor, PhD © 2010 Kimberly Anne Powers ALL RIGHTS RESERVED ii ABSTRACT Kimberly Anne Powers HIV transmission dynamics: Infectivity, sexual partnership patterns, and the role of early infection (Under the direction of William C. Miller) Although remarkable progress has been made in the diagnosis, treatment, and prevention of HIV, a cure is unavailable and many of the most promising prevention interventions have failed. At this critical juncture in the epidemic, there is a necessity for improved understanding of the fundamental drivers of the epidemic, as well as an urgent need for innovative interventions against HIV. This dissertation focuses on two of these fundamental drivers – the heterosexual infectivity of HIV-1 and the details of sexual partnership patterns – as well as the power of interventions initiated during the highly infectious period of early HIV infection (EHI). We conducted a systematic review and meta-analysis of the heterosexual infectivity of HIV-1, defined as the per-contact probability of HIV-1 transmission in a single heterosexual contact between an infected and a susceptible individual. Infectivity estimates were extremely heterogeneous, ranging from zero transmissions after more than 100 penile-vaginal contacts in some sero-discordant couples to one transmission for every 3.1 episodes of heterosexual anal intercourse.