How Unique Features of Globaldata Can Help in Building Reports and Visualizations

How unique features of GlobalData can help in building reports and visualizations

7 April 2021

www.bizint.com COVID-19 Vaccines – US, UK, & Europe VP-SCE Bullseye℠ Protein subunit modified Antigen-Presenting Cell (APC) CoVac-1 - Univ Hosp Tuebingen Live-attenuated COVI-VAC - Codagenix ABNCoV2 - AdaptVac Phase 1

COVAX 19 - GeneCure Inactivated Phase 2 KBP-COVID-19 - Kentucky BioProcessing MIVAC - Milad Phase 3 AV-COVID-19 - Aivita SP-0253 - Sanofi/GSK VLA2001 - Valneva In Review DNA Authorized RNA Covovax - Novavax mRNA 1283 - Moderna CORVax - OncoSec Phase change ARCT-021 - Arcturus COVIDeVax - Takis/Rottapharm INO 4800 - Inovio New this update BNT 162 - BioNTech/Pfizer

mRNA 1273 - Moderna VLP vaccine - Medicago CVnCoV - CureVac AZD 1222 - AstraZeneca/Oxford Virus-like particle Included: clinical phase or above in the US, UK, or mRNA-1273.351 - Moderna Ad26.COV2.S - J&J Europe. Vaccines are placed mRNA vaccine - GSK/CureVac at the highest phase Sputnik V - Gamaleya attained in any of these NasoVAX - Altimmune countries. Some vaccines VXA-CoV2-1 - Vaxart are at a higher phase globally. GRAd-COV2 - ReiThera MRT5500 - Translate/Sanofi Excluded: Vaccines only showing development outside of the selected saRNA vaccine - Imperial Coll London countries. Ad5 COVID-19 - ImmunityBio COH04S1 - City of Hope Updated March 23, 2021 AdCOVID - Altimmune Viral vector Source: Adis R&D Insight, Pharmaprojects, Cortellis, GlobalData Learn more at bizint.com/COVID Created with VantagePoint – Smart Charts Edition (VP-SCE) COVID-19 Vaccines – US, UK, & Europe

Phase I Phase II Phase III In Review Authorized

CORVax - OncoSec COVIDeVax - Takis/Rottapharm INO 4800 - Inovio Covovax - Novavax BNT 162 - BioNTech/Pfizer US Italy US Australia, EU, UK, US, Canada, NZ Multiple countries including US and EU

MIVAC - Milad VLA2001 - Valneva AV-COVID-19 - Aivita CVnCoV - CureVac mRNA 1273 - Moderna Iceland UK US Europe Multiple countries including US and EU MIVAC - Milad COVI-VAC - Codagenix ABNCoV2 - AdaptVac GRAd-COV2 - ReiThera Sputnik V - Gamaleya Ad26.COV2.S - J&J UK Iceland Netherlands Italy EU, India US, EU Liechtenstein, Norway, Canada, Iceland

CoVac-1 - Univ Hosp Tuebingen KBP-COVID-19 - Kentucky BioProcessing VLP vaccine - Medicago AZD 1222 - AstraZeneca/Oxford Germany US US, Canada Multiple countries outside of US including EU, UK, Canada, Mexico

COVAX 19 - GeneCure SP-0253 - Sanofi/GSK US, Australia Panama, US, Honduras mRNA 1283 - Moderna ARCT-021 - Arcturus US Singapore, US Vaccine type mRNA vaccine - GSK/CureVac mRNA-1273.351 - Moderna DNA US US

Inactivated saRNA vaccine - Imperial Coll London MRT5500 - Translate/Sanofi UK US, France Live-attenuated

AdCOVID - Altimmune Ad5 COVID-19 - ImmunityBio modified Antigen-Presenting Cell (APC) US US Protein subunit COH04S1 - City of Hope NasoVAX - Altimmune RNA US US Viral vector VXA-CoV2-1 - Vaxart US Virus-like particle Updated March 23, 2021 Source: Adis R&D Insight, Pharmaprojects, Cortellis, GlobalData Created with VantagePoint – Smart Charts Edition (VP-SCE) Data needed for COVID-19 vaccine visualizations… …and tabular reports too.

• Vaccine technology (usually not in the data) • Drug name + “key” company name • Current phase (highest or for indication). • Country for phase

Not all records make the category clear

© 2021 BizInt Solutions, Inc | www.bizint.com/COVID 9 COVID-19 Vaccines – from GlobalData only Live Attenuated Vaccine MIVAC Inactivated Vaccine Launched CDX005 ERUCOV-VAC Phase 3 mRNA Vaccine ARCov Phase 2 CoV-2 SAM [LNP] vaccine CovIran Barakat Phase 1 VLA2001Vero Cells LNP-nCoVsaRNA ARCT021 KD414 modRNA mRNA-1273.351 inactivated vaccineCovigen for coronavirus PTXCOVID19B QazCovidpicovaccInactivated-in SARS-CoV-2 Vaccine (Vero MRT5500 VPM1002 CADI05 cell) GX19 DNA Vaccine BBV152 saRNA CEPI BBIBPCorV CORVax12 AdCOVID ZyCoV-D GLS5310 AdCLD CoV19 CoviVac INO4800 BBV154 BNT162 TAK919 AG0302 bacTRL-Spike Recombinant Vector Vaccine COVID-eVax Ad5-nCoV C19VAZ AG0301 DelNS1-COH04S12019-nCoV-RBD-OPT1 rAd26-S UB612 KBP-COVID-19 VAC31518 EpiVacCorona vaccine COVAX-19 CIGB2020 Sputnik Light EpiVacCorona Unknown Vaccine IIBR100 VBI2902 ZF2001 GRAd-COV2 SP0253 recombinant SARS-CoV-2 vaccine (CHO Nasovax CoVLP SCB2019 TAK019 Cell) hAd5 S268019 Abdala ReCov ABNCoV2 Recombinent protein COVID-19 vaccine rAd-S-N BECOV2 RBD SARS-CoV-2 HBsAgRazi VLP Cov vaccine Pars CIGB669 Nanocovax COVID-19 EuCorVac19Vaccine GBP510MVCCOV1901 AdimrSC2f FINLAYFR 1 NBP2001

COVAX19 IMP CoVac-1 FINLAYFR1A FINLAYFR2 Subunit Vaccine Multi-database reports and visualizations Making editorial decisions…

• Here are records from 4 pipeline databases for each of 5 vaccines. • Which provide different vaccine names, company names, and phases…for the same vaccine.

• Company clean-up is harder than it looks. • How many ways can you say “Moderna”? • Can you teach software that Janssen is part of J&J? • And that the Jenner Institute and Vaccitech are affiliated with Oxford? • Often we need a single “key company.”

GlobalData identifies a single “key company” for each drug.

In the bullseye we chose to concatenate Originators and Licensees for some vaccines.

Especially for COVID! Highest Phase for the J&J vaccine, which has EUA in USA.

• None of the pipeline databases have “emergency use authorization” as a standard phase. • Citeline & GlobalData chose “Launched/Marketed” and Adis & Cortellis chose “Registered” as the highest phase.

Highest Phase for the Novavax vaccine, which has reported Phase 3 results.

• Again, we see that the databases do not assign the same phase. • We don’t want to plot a vaccine in 2 different phases, so we have to make a choice.

© 2021 BizInt Solutions, Inc | www.bizint.com/COVID 16 Lessons Learned – It’s not “Easy” Multi-Database Visualizations are Hard! We decided to create new phases – In Review and Authorized, and map the database phases to these for the bullseye.

Welcome to GlobalData! Pipeline Drugs and Clinical Trials • In BizInt Smart Charts Drug Development Suite 5.3 (released on 28 March) • Using the BizInt Smart Charts export for both drug and trials searches • See bizint.com/drugs