ACTR1A Antibody Cat. No.: 58-272

ACTR1A Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Mouse

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Monkey, Rat

This ACTR1A antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 43 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

October 1, 2021 1 https://www.prosci-inc.com/actr1a-antibody-58-272.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: ACTR1A

Alpha-centractin, Centractin, ARP1, -RPV, Centrosome-associated actin homolog, ALTERNATE NAMES: ACTR1A, CTRN1

ACCESSION NO.: P61163

PROTEIN GI NO.: 47117651

GENE ID: 10121

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This encodes a 42.6 kD subunit of , a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both and cytoplasmic . It is involved in a diverse array of cellular functions, including ER- to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle BACKGROUND: formation, movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

REFERENCES: 1) Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3521-3526(2008)

2) Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)

3) Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)

4) Carew, J.A., et al. J. Thromb. Haemost. 1(6):1220-1227(2003)

ANTIBODIES FOR RESEARCH USE ONLY.

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