ACTR1A Antibody Cat. No.: 58-272
ACTR1A Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Mouse
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Monkey, Rat
This ACTR1A antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 43 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
October 1, 2021 1 https://www.prosci-inc.com/actr1a-antibody-58-272.html PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: ACTR1A
Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ALTERNATE NAMES: ACTR1A, CTRN1
ACCESSION NO.: P61163
PROTEIN GI NO.: 47117651
GENE ID: 10121
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER- to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle BACKGROUND: formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.
REFERENCES: 1) Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3521-3526(2008)
2) Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
3) Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)
4) Carew, J.A., et al. J. Thromb. Haemost. 1(6):1220-1227(2003)
ANTIBODIES FOR RESEARCH USE ONLY.
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