CREW NPS Booklet
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Nové Rekreační Drogy
Neurotoxikologie nových „legálních rekreačních drog“ ze skupin empatogenů/entaktogenů a disociativ MUDr. S. Zakharov, CSc. Toxikologické informa ční st ředisko1 Klinika pracovního léka řství Nové rekrea ční drogy („Legal Highs“) - pojem • Nové syntetické psychoaktivní látky neuvedené v Jednotné Úmluv ě o omamných látkách, v zákonu č. 167/1998 Sb.; • Prodávají se legáln ě přes internet („smartshops“, „rostliny- zahrada-online“, „výzkumné chemikálie“, e-inzeráty, aj.) • „Je to jako hra na chemickou ruskou ruletu, protože nejsou údaje o toxicit ě, biometabolitech, fakrmakokinetice…“ (John W. Huffman) • „Clubbers‘ drugs“ – používají ~40% návštěvníků no čních klub ů •Účinky: stimulanty, empatogeny/entaktogeny, halucinogeny (psychedelika, delirianty, disociativa), sedativa, a kombinace… 2 Nové rekrea ční drogy • Výroba v Jihovýchodní Asii, Číně, balení a distribuce v Evropě a Spojených Státech. • Jednoduchá schémata syntézy (2-3 chemické reakce, běžné reagens (toluen, aceton...), vysoká stupe ň chemické čistoty (99%), nízké ceny; • Chemická struktura je podobná struktuře zakázaných (kontrolovaných) psychoaktivních látek; • „Výzkumné chemikálie“ seznam.cz –– 51 odkaz; google.cz – 82 700 odkaz ů; • www.bulkresearchchemicals.com; http://vip- 3 legals.com; www.buyanychem.com MDMA („Extáze“, éčko, koláč) – 3,4- MetylenDioxy-N-Metyl Amfetamin) • Syntezována v r. 1912 (A.Kollisch, Merck), rekrea ční použití od r. 1963, zákaz - 1985 (SZO, USA). • „Droga lásky“: empatogen ( R. Metzner, 1983) nebo entaktogen ( D. Nichols, 1986) - indukce pocit ů empatie, vcítění, soudružnosti, lásky, emoční blízkosti. • MDMA-asistovaná psychoterapie v léčbě posttraumatických stresových poruch (PTSD), (výzkum sponzorován MAPS USA (Multidisciplinary Association For Psychedelic Studies). • V ČR „malé množství“ – do 4 tbl. (400 mg). 4 Mechanismus účinku a toxicita MDMA • Efektivně uvol ňuje a inhibuje zpětné vychytávání SER (afinita k presynaptic- kému SERT), méně – DAT, NAT • Mírně nespecificky inhibuje MAO (A, B) • Mírný agonista 5-HT2-Re (změna percepce), DA2- Re (euforia), NA-Re (symp-mim. -
How Pre-Clinical Studies Have Influenced Novel Psychoactive Substance Legislation in the UK and Europe
Article How preclinical studies have influenced novel psychoactive substance legislation in the UK and Europe Santos, Raquel, Guirguis, Amira and Davidson, Colin Available at http://clok.uclan.ac.uk/31793/ Santos, Raquel ORCID: 0000-0003-3129-6732, Guirguis, Amira and Davidson, Colin ORCID: 0000-0002-8180-7943 (2020) How preclinical studies have influenced novel psychoactive substance legislation in the UK and Europe. British Journal Of Clinical Pharmacology, 86 (3). pp. 452-481. ISSN 0306-5251 It is advisable to refer to the publisher’s version if you intend to cite from the work. http://dx.doi.org/10.1111/bcp.14224 For more information about UCLan’s research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for <name of research Group>. For information about Research generally at UCLan please go to http://www.uclan.ac.uk/research/ All outputs in CLoK are protected by Intellectual Property Rights law, including Copyright law. Copyright, IPR and Moral Rights for the works on this site are retained by the individual authors and/or other copyright owners. Terms and conditions for use of this material are defined in the policies page. CLoK Central Lancashire online Knowledge www.clok.uclan.ac.uk How Pre-Clinical Studies Have Influenced Novel Psychoactive Substance Legislation in The UK and Europe Raquel Santos1, Amira Guirguis2 & Colin Davidson1* 1School of Pharmacy & Biomedical Sciences, Faculty of Clinical & Biomedical Sciences, University of Central Lancashire, UK. 2Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, Wales, UK. *Corresponding author Colin Davidson School of Pharmacy and Biomedical Science Faculty of Clinical & Biomedical Sciences University of Central Lancashire Preston PR1 2HE +44 (0)1772 89 3920 [email protected] Key words: novel psychoactive substance, legal high, legislation, toxicity, abuse Running Head: review of NPS pharmacology The authors have no conflicts of interest to declare Page | 1 Abstract Novel psychoactive substances (NPS) are new drugs of abuse. -
FSI-D-16-00226R1 Title
Elsevier Editorial System(tm) for Forensic Science International Manuscript Draft Manuscript Number: FSI-D-16-00226R1 Title: An overview of Emerging and New Psychoactive Substances in the United Kingdom Article Type: Review Article Keywords: New Psychoactive Substances Psychostimulants Lefetamine Hallucinogens LSD Derivatives Benzodiazepines Corresponding Author: Prof. Simon Gibbons, Corresponding Author's Institution: UCL School of Pharmacy First Author: Simon Gibbons Order of Authors: Simon Gibbons; Shruti Beharry Abstract: The purpose of this review is to identify emerging or new psychoactive substances (NPS) by undertaking an online survey of the UK NPS market and to gather any data from online drug fora and published literature. Drugs from four main classes of NPS were identified: psychostimulants, dissociative anaesthetics, hallucinogens (phenylalkylamine-based and lysergamide-based materials) and finally benzodiazepines. For inclusion in the review the 'user reviews' on drugs fora were selected based on whether or not the particular NPS of interest was used alone or in combination. NPS that were use alone were considered. Each of the classes contained drugs that are modelled on existing illegal materials and are now covered by the UK New Psychoactive Substances Bill in 2016. Suggested Reviewers: Title Page (with authors and addresses) An overview of Emerging and New Psychoactive Substances in the United Kingdom Shruti Beharry and Simon Gibbons1 Research Department of Pharmaceutical and Biological Chemistry UCL School of Pharmacy -
Overview of the Misuse of Drugs Act 1971
Psychoactive Substances Bill Factsheet: Overview of the Misuse of Drugs Act 1971 1. The provisions of the Psychoactive Substances Bill will build on and complement the existing legislative framework for the control of dangerous drugs as contained in the Misuse of Drugs Act 1971 (the 1971 Act). This factsheet provides an overview of the provisions of the 1971 Act. The Misuse of Drugs Act 1971 2. The 1971 Act provides the legislative framework for the regulation of “dangerous or otherwise harmful” drugs; the Act applies to the whole of the United Kingdom. The 1971 Act implements the UK’s international obligations under the United Nations Conventions for the prevention of drug misuse and trafficking, namely the Single Convention on Narcotic Drugs 19611 and the Convention on Psychotropic Substances 19712, which are complemented by the Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances 19883. 3. The 1971 Act applies to "controlled drugs". This includes substances or products specified in Schedule 2 to the Act. That Schedule divides controlled drugs into one of three Classes – A, B and C – broadly based on their relative harms, with Class A drugs considered the most harmful. Examples of each class of drug are: Class A - cocaine, methadone and opium; Class B - amphetamine, cannabis and ketamine; Class C - khat and temazepam. In addition, controlled drugs include any substance or product specified in a temporary class drug order as a drug subject to temporary control (see below). 4. The 1971 Act provides for a range of offences in relation to controlled drugs, including: • importation and exportation (section 3); • production, supply or offering to supply (section 4); • possession and possession with intent to supply (section 5); and • permitting premises to be used for certain activities, including the production or supply of a controlled drug and smoking cannabis (section 8). -
Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; a Web-Based Approach
ORIGINAL RESEARCH published: 09 February 2021 doi: 10.3389/fpsyt.2020.632405 Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach Valeria Catalani 1*, Davide Arillotta 1, John Martin Corkery 1, Amira Guirguis 1,2, Alessandro Vento 3,4,5 and Fabrizio Schifano 1 1 Psychopharmacology, Drug Misuse & Novel Psychoactive Substances Research Unit, School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 2 Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, United Kingdom, 3 Department of Mental Health, ASL Roma 2, Rome, Italy, 4 Addictions’ Observatory (ODDPSS), Rome, Italy, 5 Department of Psychology, Guglielmo Marconi University, Rome, Italy COVID-19-related disruptions of people and goods’ circulation can affect drug markets, especially for new psychoactive substances (NPSs). Drug shortages could cause a change in available NPS, with the introduction of new, unknown, substances. The aims of the current research were to use a web crawler, NPSfinder®, to identify and categorize emerging NPS discussed on a range of drug enthusiasts/psychonauts’ websites/fora at the time of the pandemic; social media for these identified NPS were screened as Edited by: well. The NPSfinder® was used here to automatically scan 24/7 a list of psychonaut Ornella Corazza, University of Hertfordshire, websites and NPS online resources. The NPSs identified in the time frame between United Kingdom January and August 2020 were searched in both the European Monitoring Center Reviewed by: for Drugs and Drug Addictions (EMCDDA)/United Nations Office on Drugs and Crime Simona Zaami, Sapienza University of Rome, Italy (UNODC) databases and on social media (Facebook, Twitter, Instagram, Pinterest, Laura Hondebrink, and YouTube) as well, with a content qualitative analysis having been carried out on University Medical Center reddit.com. -
(12) Patent Application Publication (10) Pub. No.: US 2004/0224012 A1 Suvanprakorn Et Al
US 2004O224012A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0224012 A1 Suvanprakorn et al. (43) Pub. Date: Nov. 11, 2004 (54) TOPICAL APPLICATION AND METHODS Related U.S. Application Data FOR ADMINISTRATION OF ACTIVE AGENTS USING LIPOSOME MACRO-BEADS (63) Continuation-in-part of application No. 10/264,205, filed on Oct. 3, 2002. (76) Inventors: Pichit Suvanprakorn, Bangkok (TH); (60) Provisional application No. 60/327,643, filed on Oct. Tanusin Ploysangam, Bangkok (TH); 5, 2001. Lerson Tanasugarn, Bangkok (TH); Suwalee Chandrkrachang, Bangkok Publication Classification (TH); Nardo Zaias, Miami Beach, FL (US) (51) Int. CI.7. A61K 9/127; A61K 9/14 (52) U.S. Cl. ............................................ 424/450; 424/489 Correspondence Address: (57) ABSTRACT Eric G. Masamori 6520 Ridgewood Drive A topical application and methods for administration of Castro Valley, CA 94.552 (US) active agents encapsulated within non-permeable macro beads to enable a wider range of delivery vehicles, to provide longer product shelf-life, to allow multiple active (21) Appl. No.: 10/864,149 agents within the composition, to allow the controlled use of the active agents, to provide protected and designable release features and to provide visual inspection for damage (22) Filed: Jun. 9, 2004 and inconsistency. US 2004/0224012 A1 Nov. 11, 2004 TOPCAL APPLICATION AND METHODS FOR 0006 Various limitations on the shelf-life and use of ADMINISTRATION OF ACTIVE AGENTS USING liposome compounds exist due to the relatively fragile LPOSOME MACRO-BEADS nature of liposomes. Major problems encountered during liposome drug Storage in vesicular Suspension are the chemi CROSS REFERENCE TO OTHER cal alterations of the lipoSome compounds, Such as phos APPLICATIONS pholipids, cholesterols, ceramides, leading to potentially toxic degradation of the products, leakage of the drug from 0001) This application claims the benefit of U.S. -
Socio-Demographic and Clinical Characteristics of Benzodiazepine Long-Term Users: Results from a Tertiary Care Center ⁎ F
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Florence Research Available online at www.sciencedirect.com ScienceDirect Comprehensive Psychiatry 69 (2016) 211–215 www.elsevier.com/locate/comppsych Socio-demographic and clinical characteristics of benzodiazepine long-term users: Results from a tertiary care center ⁎ F. Coscia, , G. Mansuetoa, M. Faccinib, R. Casarib, F. Lugobonib aDepartment of Health Sciences, University of Florence, via di San Salvi 12, 50135, Florence, Italy bAddiction Unit, Verona University Hospital, piazzale Aristide Stefani 1, 37126, Verona, Italy Abstract Objective: The use of benzodiazepines (BDZs) represents a critical issue since a long-term treatment may lead to dependence. This study aimed at evaluating socio-demographic and clinical characteristics of BZD long-term users who followed a detoxification program at a tertiary care center. Method: Two hundred-five inpatients were evaluated. Socio-demographic (e.g., gender, age, education) and clinical information (e.g., BZD used, dose, reason of prescription) was collected. BZDs dose was standardized as diazepam dose equivalents and was compared via the Defined Daily Dose (DDD). Chi-square, Fisher test, ANOVA and Bonferroni analyses were performed. Results: Females were more frequently BDZ long-term users than males. Hypnotic BZDs were frequently prescribed for problems different from sleep disturbances. Lorazepam, alprazolam, and lormetazepam were the most prescribed drugs. Lorazepam was more frequently used by males, consumed for a long period, in pills, and prescribed for anxiety. Lormetazepam was more frequently consumed by females with a high school education, having a psychiatric disorder, taken in drops and prescribed for insomnia. -
Acute Toxicity Associated with the Recreational Use of the Novel Dissociative Psychoactive Substance Methoxphenidine
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2014 Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine Hofer, K E ; Degrandi, C ; Müller, D M ; Zürrer-Härdi, U ; Wahl, S ; Rauber-Lüthy, C ; Ceschi, A Abstract: INTRODUCTION: Methoxphenidine is a novel dissociative designer drug of the diarylethy- lamine class which shares structural features with phencyclidine (PCP), and is not at present subject to restrictive regulations. There is very limited information about the acute toxicity profile of methoxpheni- dine and the only sources are anonymous internet sites and a 1989 patent of the Searle Company. We report a case of analytically confirmed oral methoxphenidine toxicity. CASE DETAILS: A 53-year-old man was found on the street in a somnolent and confusional state. Observed signs and symptoms such as tachycardia (112 bpm), hypertension (220/125 mmHg), echolalia, confusion, agitation, opisthotonus, nys- tagmus and amnesia were consistent with phencyclidine-induced adverse effects. Temperature (99.1°F (37.3°C)) and peripheral oxygen saturation while breathing room air (99%) were normal. Laboratory analysis revealed an increase of creatine kinase (max 865 U/L), alanine aminotransferase (72 U/L) and gamma-glutamyl transpeptidase (123 U/L). Methoxphenidine was identified by a liquid chromatogra- phy tandem mass spectrometry toxicological screening method using turbulent flow online extraction in plasma and urine samples collected on admission. The clinical course was favourable and signs and symptoms resolved with symptomatic treatment. CONCLUSION: Based on this case report and users’ web reports, and compatible with the chemical structure, methoxphenidine produces effects similar to those of the arylcyclohexylamines, as PCP. -
124.204 Schedule I — Substances Included. 1. Schedule I Shall Consist
1 , §124.204 124.204 Schedule I — substances included. 1. Schedule I shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. 2. Opiates. Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation: a. Acetylmethadol. b. Allylprodine. c. Alphacetylmethadol (except levo-alphacetylmethadol also known as levo-alpha- acetylmethadol, levomethadyl acetate, or LAAM). d. Alphameprodine. e. Alphamethadol. f. Alpha-Methylfentanyl (N-(1-(alpha-methyl-beta-phenyl) ethyl-4-piperidyl) propionanilide; 1-(1-methyl-2-phenylethyl)-4-(N-propanilido)piperidine). g. Benzethidine. h. Betacetylmethadol. i. Betameprodine. j. Betamethadol. k. Betaprodine. l. Clonitazene. m. Dextromoramide. n. Difenoxin. o. Diampromide. p. Diethylthiambutene. q. Dimenoxadol. r. Dimepheptanol. s. Dimethylthiambutene. t. Dioxaphetyl butyrate. u. Dipipanone. v. Ethylmethylthiambutene. w. Etonitazene. x. Etoxeridine. y. Furethidine. z. Hydroxypethidine. aa. Ketobemidone. ab. Levomoramide. ac. Levophenacylmorphan. ad. Morpheridine. ae. Noracymethadol. af. Norlevorphanol. ag. Normethadone. ah. Norpipanone. ai. Phenadoxone. aj. Phenampromide. ak. Phenomorphan. al. Phenoperidine. am. Piritramide. an. Proheptazine. ao. Properidine. ap. Propiram. aq. Racemoramide. ar. Tilidine. as. Trimeperidine. at. Beta-hydroxy-3-methylfentanyl (other name: N-[1-(2-hydroxy-2-phenethyl)- 3-methyl-4-piperidinyl]-N-phenylpropanamide). Thu May 19 07:35:43 2016 Iowa Code 2016, Section 124.204 (25, 1) §124.204, 2 au. Acetyl-alpha-methylfentanyl (N-[1-(1-methyl-2-phenethyl)-4-piperidinyl]-N- phenylacetamide). av. -
Texas Controlled Substances Act
HEALTH AND SAFETY CODE TITLE 6. FOOD, DRUGS, ALCOHOL, AND HAZARDOUS SUBSTANCES SUBTITLE C. SUBSTANCE ABUSE REGULATION AND CRIMES CHAPTER 481. TEXAS CONTROLLED SUBSTANCES ACT SUBCHAPTER A. GENERAL PROVISIONS Sec.A481.001.AASHORT TITLE. This chapter may be cited as the Texas Controlled Substances Act. Acts 1989, 71st Leg., ch. 678, Sec. 1, eff. Sept. 1, 1989. Sec.A481.002.AADEFINITIONS. In this chapter: (1)AA"Administer" means to directly apply a controlled substance by injection, inhalation, ingestion, or other means to the body of a patient or research subject by: (A)AAa practitioner or an agent of the practitioner in the presence of the practitioner; or (B)AAthe patient or research subject at the direction and in the presence of a practitioner. (2)AA"Agent" means an authorized person who acts on behalf of or at the direction of a manufacturer, distributor, or dispenser. The term does not include a common or contract carrier, public warehouseman, or employee of a carrier or warehouseman acting in the usual and lawful course of employment. (3)AA"Commissioner" means the commissioner of state health services or the commissioner 's designee. (4)AA"Controlled premises" means: (A)AAa place where original or other records or documents required under this chapter are kept or are required to be kept; or (B)AAa place, including a factory, warehouse, other establishment, or conveyance, where a person registered under this chapter may lawfully hold, manufacture, distribute, dispense, administer, possess, or otherwise dispose of a controlled substance or other item governed by the federal Controlled Substances Act (21 U.S.C. -
ETIZOLAM Critical Review Report Agenda Item 4.13
ETIZOLAM Critical Review Report Agenda Item 4.13 Expert Committee on Drug Dependence Thirty-ninth Meeting Geneva, 6-10 November 2017 39th ECDD (2017) Agenda item 4.13 Etizolam Page 2 of 20 39th ECDD (2017) Agenda item 4.13 Etizolam Contents Acknowledgements.................................................................................................................................. 5 Summary...................................................................................................................................................... 6 1. Substance identification ....................................................................................................................... 7 A. International Nonproprietary Name (INN).......................................................................................................... 7 B. Chemical Abstract Service (CAS) Registry Number .......................................................................................... 7 C. Other Chemical Names ................................................................................................................................................... 7 D. Trade Names ....................................................................................................................................................................... 7 E. Street Names ....................................................................................................................................................................... 8 F. Physical Appearance -
ETIZOLAM in POST-MORTEM CASES Joanna Hockenhull1
ETIZOLAM IN POST-MORTEM CASES Joanna Hockenhull1 1Toxicology Unit, Faculty of Medicine, Imperial College London. INTRODUCTION: Etizolam [4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine] is a benzodiazepine analogue. The benzene ring is replaced with a thiophene ring making the drug a ‘thienodiazepine’. This poster reviews four post-mortem cases, submitted to Imperial College Toxicology Unit, in which etizolam was detected in the post-mortem, femoral blood. RESULTS: The findings are summarised in the tables below. Medicinal use: • Widely available in Japan (Depas, Sedekopan ) and India (Etilaam, Etizola). CASE 1: CASE 2: • Adult daily doses range from 0.5 – 3.0 milligrams. • 52 year old female • 47 year old male • Used in short-term treatment of insomnia or anxiety. 1 • Found dead in church yard surrounded by empty • History of alcohol abuse and depression 2 • Acts as a full agonist at the benzodiazepine receptor. medication packets • Has potent hypnotic properties comparable with other short-acting • Found dead in bed surrounded by empty medication benzodiazepines. Drug Blood Concentration packets. • (Etizolam has anxiolytic effects six times greater than diazepam). 3 ETIZOLAM 0.09 µg/ml Drug Blood Concentration 4 • Thought to have reduced tolerance/dependence than classical benzodiazepines. Diphenhydramine High therapeutic ETIZOLAM 0.46 µg/ml FIGURE 1: Structure of Etizolam • However, long-term use may produce similar side-effects to benzodiazepines: Venlafaxine 7.10 µg/ml 5 Amitriptyline High therapeutic addiction, hostile behaviour, memory loss and severe withdrawal. Mirtazapine 1.41 µg/ml Illicit use: Ethanol <10 mg/dL Citalopram 0.79 µg/ml • Etizolam is not licenced as a medicine in the UK.