June 8, 2021 u vol. 118 u no. 23

From the Cover

e2020680118 Ancient origins of primitive kimberlite e2102588118 Turbulence in golden eagle flight e2025400118 Artificial intelligence monitors war destruction e2101634118 Developmental plasticity in clownfish pigmentation e2018188118 Neuronal basis of duet singing in birds

Contents

THIS WEEK IN PNAS—This week’s research highlights eiti2321118 In This Issue Cover image: Pictured is a thin section of Grizzly kimberlite from Lac de Gras, Canada, displaying colorful crystals of NEWS FEATURE—An in-depth look at trending science issues the mineral olivine. Nao Nakanishi et al. e2108401118 Keeping Black students in STEM measured the isotope compositions of Melissa Suran primitive kimberlites, which are igneous rocks derived from deep mantle sources, from 10 localities, ranging in age from QNAS—Interviews with leading scientific researchers and newsmakers 1,153 million to 89 million years, to e2107569118 QnAs with Clare M. Waterman probe the rocks’ origins. The authors Sandeep Ravindran found that the kimberlite samples have comparatively uniform tungsten-182/ See Inaugural Article, e2021135118, in vol. 118, issue 22 tungsten-184 isotope ratios averaging around 6 parts per million lower than COMMENTARIES the ratio in the upper mantle. This low tungsten isotope ratio suggests that e2106306118 Policy to activate cultural change to amplify policy primitive kimberlites formed from one Charles Efferson or more deep mantle reservoirs that See companion article, e2014893118, in vol. 118, issue 16 ’ developed early in Earth s history and e2107021118 Why zebra finches don’t get hypercholesterolemia remained isolated for a period of at Stephanie A. White and Timothy F. Wright least 1 billion years. See the article by See companion article, e2025167118, in vol. 118, issue 18 Nakanishi et al., e2020680118. Image credit: Nao Nakanishi et al. e2107024118 Computational explorations in the space of one-component crystals Jonathan P. K. Doye and Eva G. Noya See companion article, e2024034118, in vol. 118, issue 21

PERSPECTIVE e2022239118 The persistent threat of emerging plant disease pandemics to global food security Jean B. Ristaino, Pamela K. Anderson, Daniel P. Bebber, Kate A. Brauman, Nik J. Cunniffe, Nina V. Fedoroff, Cambria Finegold, Karen A. Garrett, Christopher A. Gilligan, Christopher M. Jones, Michael D. Martin, Graham K. MacDonald, Patricia Neenan, Angela Records, David G. Schmale, Laura Tateosian, and Qingshan Wei

LETTERS e2025958118 Models of marine protected areas must explicitly address spatial dynamics Daniel Ovando, Owen Liu, Renato Molina, and Cody Szuwalski

Free online through the PNAS open access option. PNAS u June 8, 2021 u vol. 118 u no. 23 u iii–viii Downloaded by guest on September 24, 2021 e2100364118 Reply to Ovando et al.: How connected are EARTH, ATMOSPHERIC, AND PLANETARY global fisheries? SCIENCES Reniel B. Cabral, Darcy Bradley, Juan Mayorga, e2023617118 A CO2 greenhouse efficiently warmed Whitney Goodell, Alan M. Friedlander, Enric Sala, the early Earth and decreased seawater Christopher Costello, and Steven D. Gaines 18O/16O before the onset of plate tectonics Daniel Herwartz, Andreas Pack, BRIEF REPORTS and Thorsten J. Nagel e2101357118 Evolution of single gyroid photonic crystals in e2024898118 Early Holocene greening of the Sahara bird feathers requires Mediterranean winter rainfall Vinodkumar Saranathan, Suresh Narayanan, Alec Rachid Cheddadi, Matthieu Carre´, Majda Nourelbait, Sandy, Eric R. Dufresne, and Richard O. Prum Louis Franc¸ois, Ali Rhoujjati, Roger Manay, Diana e2100766118 Analyzing the vast coronavirus literature Ochoa, and Enno Schefuß with CoronaCentral e2020680118 Tungsten-182 evidence for an ancient Jake Lever and Russ B. Altman kimberlite source Nao Nakanishi, Andrea Giuliani, Richard W. Carlson, Mary F. Horan, Jon Woodhead, D. Graham Pearson, PHYSICAL SCIENCES and Richard J. Walker

APPLIED PHYSICAL SCIENCES e2101544118 Petrographic carbon in ancient sediments constrains Proterozoic Era atmospheric e2103215118 Periodic bouncing of a plasmonic bubble in oxygen levels a binary liquid by competing solutal and Don E. Canfield, Mark A. van Zuilen, Sami Nabhan, thermal Marangoni forces Christian J. Bjerrum, Shuichang Zhang, Huajian Wang, 曾炳霖 庄启亮 Binglin Zeng ( ), Kai Leong Chong ( ), and Xiaomei Wang Yuliang Wang (王玉亮), Christian Diddens, Xiaolai Li (李晓来), Marvin Detert, Harold J. W. Zandvliet, e2016549118 Significant impact of forcing uncertainty and Detlef Lohse in a large ensemble of climate model simulations BIOPHYSICS AND COMPUTATIONAL BIOLOGY John C. Fyfe, Viatcheslav V. Kharin, Benjamin D. Santer, Jason N. S. Cole, and Nathan P. Gillett e2102621118 Revealing atomic-scale molecular diffusion of a plant-transcription factor WRKY domain e2025400118 Monitoring war destruction from space using protein along DNA machine learning Liqiang Dai, Yongping Xu, Zhenwei Du, Xiao-dong Su, Hannes Mueller, Andre Groeger, Jonathan Hersh, and Yu Andrea Matranga, and Joan Serrat e2104245118 Simulating the directional translocation of + a substrate by the AAA motor in the ENGINEERING 26S proteasome e2104765118 Knowledge extraction and transfer in data- Arjun Saha and Arieh Warshel driven fracture mechanics e2104598118 Single-molecule calorimeter and free Xing Liu, Christos E. Athanasiou, Nitin P. Padture, energy landscape Brian W. Sheldon, and Huajian Gao Yi Wang, Zhuodong Tang, Hong-Yuan , Wei e2102588118 Turbulence explains the accelerations of an Wang, Nongjian Tao, and Hui Wang eagle in natural flight Kasey M. Laurent, Bob Fogg, Tobias Ginsburg, CHEMISTRY Casey Halverson, Michael J. Lanzone, e2102168118 Identifying the origin of local flexibility in Tricia A. Miller, David W. Winkler, a carbohydrate polymer and Gregory P. Bewley Kelvin Anggara, Yuntao Zhu, Giulio Fittolani, Yang Yu, e2008276118 A minimally disruptive method for measuring Theodore Tyrikos-Ergas, Martina Delbianco, Stephan water potential in planta using Rauschenbach, Sabine Abb, Peter H. Seeberger, hydrogel nanoreporters and Klaus Kern Piyush Jain, Weizhen Liu, Siyu Zhu, Christine Yao-Yun e2020160118 Persistent polyamorphism in the chiton tooth: Chang, Jeff Melkonian, Fulton E. Rockwell, Duke From a new biomineral to inks for Pauli, Ying Sun, Warren R. Zipfel, N. Michele additive manufacturing Holbrook, Susan Jean Riha, Michael A. Gore, Linus Stegbauer, Paul J. M. Smeets, Robert Free, and Abraham D. Stroock Shay G. Wallace, Mark C. Hersam, Esen E. Alp, e2102583118 Phosphate Elimination and Recovery and Derk Joester Lightweight (PEARL) membrane: A e2012666118 “Soft” oxidative coupling of methane to sustainable environmental ethylene: Mechanistic insights from combined remediation approach experiment and theory Stephanie M. Ribet, Benjamin Shindel, Roberto dos Shanfu Liu, Sagar Udyavara, Chi Zhang, Matthias Peter, Reis, Vikas Nandwana, and Vinayak P. Dravid Tracy L. Lohr, Vinayak P. Dravid, Matthew Neurock, e2024329118 Self-adaptive and efficient propulsion of and Tobin J. Marks Ray sperms at different viscosities e2019863118 Biosynthesis of fosfomycin in pseudomonads enabled by heterogeneous reveals an unexpected enzymatic activity in dual helixes the metallohydrolase superfamily Panbing Wang, M. A. R. Al Azad, Xiong Yang, Max A. Simon, Chayanid Ongpipattanakul, Satish K. Paolo R. Martelli, Kam Yan Cheung, Jiahai Shi, Nair, and Wilfred A. van der Donk and Yajing Shen

iv u www.pnas.org Contents Downloaded by guest on September 24, 2021 ENVIRONMENTAL SCIENCES APPLIED BIOLOGICAL SCIENCES e2018277118 Paleo-ENSO influence on African e2026658118 High-throughput developability assays enable environments and early modern humans library-scale identification of producible Stefanie Kaboth-Bahr, William D. Gosling, Ralf protein scaffold variants Vogelsang, Andre´ Bahr, Eleanor M. L. Scerri, Alexander W. Golinski, Katelynn M. Mischler, Sidharth Asfawossen Asrat, Andrew S. Cohen, Walter Du¨sing, Laxminarayan, Nicole L. Neurock, Matthew Fossing, Verena Foerster, Henry F. Lamb, Mark A. Hannah Pichman, Stefano Martiniani, Maslin, Helen M. Roberts, Frank Scha¨bitz, and Benjamin J. Hackel and Martin H. Trauth e2105067118 Liquid crystal display screens as a source for BIOCHEMISTRY indoor volatile organic compounds e2104598118 Single-molecule calorimeter and free Qifan Liu and Jonathan P. D. Abbatt energy landscape Yi Wang, Zhuodong Tang, Hong-Yuan Chen, Wei SUSTAINABILITY SCIENCE Wang, Nongjian Tao, and Hui Wang e2102583118 Phosphate Elimination and Recovery e2019863118 Biosynthesis of fosfomycin in pseudomonads Lightweight (PEARL) membrane: A reveals an unexpected enzymatic activity in sustainable environmental the metallohydrolase superfamily remediation approach Max A. Simon, Chayanid Ongpipattanakul, Satish K. Stephanie M. Ribet, Benjamin Shindel, Roberto dos Nair, and Wilfred A. van der Donk Reis, Vikas Nandwana, and Vinayak P. Dravid e2103990118 Multiple deprotonation paths of the e2012649118 CO reduction on pure Cu produces only H 2 2 nucleophile 3′-OH in the DNA after subsurface O is depleted: Theory synthesis reaction and experiment Mark T. Gregory, Yang Gao, Qiang Cui, and Wei Yang Guiji Liu, Michelle Lee, Soonho Kwon, Guosong Zeng, Johanna Eichhorn, Aya K. Buckley, F. Dean Toste, e2100844118 Conformation and dynamics of the kinase William A. Goddard III, and Francesca M. Toma domain drive subcellular location and activation of LRRK2 SOCIAL SCIENCES Sven H. Schmidt, Jui-Hung Weng, Phillip C. Aoto, ECONOMIC SCIENCES Daniela Boassa, Sebastian Mathea, Steve Silletti, Junru Hu, Maximilian Wallbott, Elizabeth A. e2026112118 Converging evidence for greater male Komives, Stefan Knapp, Friedrich W. Herberg, variability in time, risk, and social preferences and Susan S. Taylor Christian Tho¨ni and Stefan Volk e2100680118 Copper binding by a unique family of POLITICAL SCIENCES metalloproteins is dependent on e2025400118 Monitoring war destruction from space using kynurenine formation machine learning Anastasia C. Manesis, Richard J. Jodts, Brian M. Hoffman, and Amy C. Rosenzweig Hannes Mueller, Andre Groeger, Jonathan Hersh, Andrea Matranga, and Joan Serrat e2022704118 Molecular basis of the dual role of the Mlh1- e2019527118 Overconfidence in news judgments is Mlh3 endonuclease in MMR and in meiotic associated with false news susceptibility crossover formation Benjamin A. Lyons, Jacob M. Montgomery, Andrew M. Jingqi Dai, Aurore Sanchez, Ce´line Adam, Lepakshi Guess, Brendan Nyhan, and Jason Reifler Ranjha, Giordano Reginato, Pierre Chervy, Carine Tellier-Lebegue, Jessica Andreani, Raphae¨l Gue´rois, e2024125118 Elite rhetoric can undermine Virginie Ropars, Marie-He´le`ne Le Du, Laurent democratic norms Maloisel, Emmanuelle Martini, Pierre Legrand, Katherine Clayton, Nicholas T. Davis, Brendan Nyhan, Aure´lien Thureau, Petr Cejka, Vale´rie Borde, Ethan Porter, Timothy J. Ryan, and Thomas J. Wood and Jean-Baptiste Charbonnier

PSYCHOLOGICAL AND COGNITIVE SCIENCES e2011278118 SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled e2021793118 Collectivism predicts mask use replication fork restart in response during COVID-19 to DNA replication stress Jackson G. , Peter Jin, and Alexander S. English Qian Zhu, Qiaoyan Yang, Xiaopeng Lu, Hui Wang, Lili SOCIAL SCIENCES Tong, Li, Ge Liu, Yantao Bao, Xingzhi Xu, Luo e2100846118 The effect of mass shootings on daily emotions Gu, Jian Yuan, Xiangyu Liu, and Wei-Guo Zhu is limited by time, geographic proximity, e2015037118 Generation of ordered protein assemblies and political affiliation using rigid three-body fusion Patrick Sharkey and Yinzhi Shen Ivan Vulovic, Qing Yao, Young-Jun Park, Alexis Courbet, Andrew Norris, Florian Busch, Aniruddha BIOLOGICAL SCIENCES Sahasrabuddhe, Hannes Merten, Danny D. Sahtoe, George Ueda, Jorge A. Fallas, Sara J. Weaver, Yang ANTHROPOLOGY Hsia, Robert A. Langan, Andreas Plu¨ckthun, Vicki H. Wysocki, David Veesler, Grant J. Jensen, and David Baker e2018277118 Paleo-ENSO influence on African environments and early modern humans e2022447118 Tryptophanemia is controlled by a tryptophan- Stefanie Kaboth-Bahr, William D. Gosling, Ralf sensing mechanism ubiquitinating Vogelsang, Andre´ Bahr, Eleanor M. L. Scerri, tryptophan 2,3-dioxygenase Asfawossen Asrat, Andrew S. Cohen, Walter Du¨sing, Simon Klaessens, Vincent Stroobant, Delia Verena Foerster, Henry F. Lamb, Mark A. Hoffmann, Mads Gyrd-Hansen, Luc Pilotte, Maslin, Helen M. Roberts, Frank Scha¨bitz, Nathalie Vigneron, Etienne De Plaen, and Martin H. Trauth and Benoit J. Van den Eynde

Contents PNAS u June 8, 2021 u vol. 118 u no. 23 u v Downloaded by guest on September 24, 2021 BIOPHYSICS AND COMPUTATIONAL BIOLOGY DEVELOPMENTAL BIOLOGY e2102621118 Revealing atomic-scale molecular diffusion of e2101634118 Thyroid hormones regulate the formation and a plant-transcription factor WRKY domain environmental plasticity of white bars protein along DNA in clownfishes Liqiang Dai, Yongping Xu, Zhenwei Du, Xiao-dong Su, Pauline Salis, Natacha Roux, Delai Huang, Anna and Jin Yu Marcionetti, Pierick Mouginot, Mathieu Reynaud, e2024329118 Self-adaptive and efficient propulsion of Oce´ane Salles, Nicolas Salamin, Benoit Pujol, David M. Parichy, Serge Planes, and Vincent Laudet Ray sperms at different viscosities enabled by heterogeneous e2020120118 Tumors overcome the action of the wasting dual helixes factor ImpL2 by locally elevating Wnt/Wingless Panbing Wang, M. A. R. Al Azad, Xiong Yang, Jiae Lee, Katelyn G.-L. Ng, Kenneth M. Dombek, Dae Paolo R. Martelli, Kam Yan Cheung, Jiahai Shi, Seok Eom, and Young V. Kwon and Yajing Shen e2024067118 Sexual fate of murine external genitalia e2011659118 A reverse stroke characterizes the force development: Conserved transcriptional generation of cardiac myofilaments, leading competency for male-biased genes in both sexes to an understanding of heart function Daiki Kajioka, Kentaro Suzuki, Shoko Matsushita, Yongtae Hwang, Takumi Washio, Toshiaki Hisada, Shinjiro Hino, Tetsuya Sato, Shuji Takada, Kyoichi Hideo Higuchi, and Motoshi Kaya Isono, Toru Takeo, Mizuki Kajimoto, Naomi Nakagata, Mitsuyoshi Nakao, Mikita Suyama, Tony DeFalco, e2101349118 Periscope Proteins are variable-length Shinichi Miyagawa, and Gen Yamada regulators of bacterial cell surface interactions e2102691118 Temporal integration of inductive cues on the Fiona Whelan, Aleix Lafita, James Gilburt, Cle´ment De´gut, Samuel C. Griffiths, Huw T. Jenkins, way to gastrulation Alexander N. St John, Emanuele Paci, James W. B. Sarah McFann, Sayantan Dutta, Jared E. Toettcher, Moir, Michael J. Plevin, Christoph G. Baumann, Alex and Stanislav Y. Shvartsman Bateman, and Jennifer R. Potts ECOLOGY e2104897118 Interaction hot spots for phase separation e2102588118 Turbulence explains the accelerations of an revealed by NMR studies of a CAPRIN1 eagle in natural flight condensed phase Kasey M. Laurent, Bob Fogg, Tobias Ginsburg, Tae Hun Kim, Brandon J. Payliss, Michael L. Nosella, Casey Halverson, Michael J. Lanzone, Ian T. W. Lee, Yuki Toyama, Julie D. Forman-Kay, Tricia A. Miller, David W. Winkler, and Lewis E. Kay and Gregory P. Bewley e2024605118 ALS-linked PFN1 variants exhibit loss and gain ENVIRONMENTAL SCIENCES of functions in the context of formin-induced e2102225118 Characterizing the “fungal shunt”: Parasitic fungi actin polymerization on diatoms affect carbon flow and bacterial Eric J. Schmidt, Salome Funes, Jeanne E. McKeon, communities in aquatic microbial food webs Brittany R. Morgan, Sivakumar Boopathy, Lauren C. O’Connor, Osman Bilsel, Francesca Massi, Antoine Isabell Klawonn, Silke Van den Wyngaert, Alma E. Je´gou, and Daryl A. Bosco Parada, Nestor Arandia-Gorostidi, Martin J. Whitehouse, Hans-Peter Grossart, and Anne E. Dekas EVOLUTION CELL BIOLOGY e2101486118 A chromosome-level genome of a Kordofan e2104841118 AP-1 is a temporally regulated dual gatekeeper melon illuminates the origin of of reprogramming to pluripotency domesticated watermelons Glenn J. Markov, Thach Mai, Surag Nair, Anna Shcherbina, Yu Xin Wang, David M. Burns, Anshul Susanne S. Renner, Shan Wu, Oscar A. Pe´rez-Escobar, Kundaje, and Helen M. Blau Martina V. Silber, Zhangjun Fei, and Guillaume Chomicki e2104650118 Regulation of cold-induced thermogenesis by e2104592118 Coevolutionary phage training leads to the RNA binding protein FAM195A greater bacterial suppression and Jessica Cannavino, Mengle Shao, Yu A. An, Svetlana delays the evolution of phage resistance Bezprozvannaya, Shiuhwei Chen, Jiwoong Kim, Lin Xu, Joshua M. Borin, Sarit Avrani, Jeffrey E. Barrick, John R. McAnally, Philipp E. Scherer, Ning Liu, Rana Katherine L. Petrie, and Justin R. Meyer K. Gupta, Rhonda Bassel-Duby, and Eric N. Olson e2022169118 Genomics-informed models reveal extensive e2019740118 Mitochondrial apoptotic priming is a key stretches of coastline under threat by an determinant of cell fate upon p53 restoration ecologically dominant invasive species Francisco J. Sa´nchez-Rivera, Jeremy Ryan, Yadira M. Jamie Hudson, Juan Carlos Castilla, Peter R. Teske, Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David Luciano B. Beheregaray, Ivan D. Haigh, Christopher D. M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya McQuaid, and Marc Rius Dimitrova, Anthony Letai, and Tyler Jacks e2100559118 Transposon-mediated insertional mutagenesis e2103383118 On and off controls within dynein–dynactin on unmasks recessive insecticide resistance in native cargoes the aphid Myzus persicae Paulomi Sanghavi, Pankaj Kumar, Ankit Roy, M. S. Michela Panini, Olga Chiesa, Bartlomiej J. Troczka, Madhusudhan, and Roop Mallik Mark Mallott, Gian Carlo Manicardi, Stefano Cassanelli, e2024690118 Cell-type–specific, multicolor labeling of Filippo Cominelli, Alex Hayward, Emanuele Mazzoni, and Chris Bass endogenous proteins with split fluorescent protein tags in Drosophila e2019294118 Developmental influence on evolutionary Rie Kamiyama, Kota Banzai, Peiwei Liu, Abhijit Marar, rates and the origin of placental mammal Ryo Tamura, Fangchao Jiang, Miyuki A. Fitch, Jin Xie, tooth complexity and Daichi Kamiyama Aidan M. C. Couzens, Karen E. Sears, and Martin Ru¨cklin

vi u www.pnas.org Contents Downloaded by guest on September 24, 2021 GENETICS e2101668118 Spatial distribution of LTi-like cells in intestinal e2104131118 Genetic basis of variation in cocaine mucosa regulates type 3 innate immunity and methamphetamine consumption Cristiane Se´cca, Jennifer K. Bando, Jose´ L. Fachi, in outbred populations of Drosophila Susan Gilfillan, Vincent Peng, Blanda Di Luccia, Marina melanogaster Cella, Keely G. McDonald, Rodney D. Newberry, and Marco Colonna Brandon M. Baker, Mary Anna Carbone, Wen Huang, Robert R. H. Anholt, and Trudy F. C. Mackay e2104254118 Sequence of the supernumerary B MEDICAL SCIENCES chromosome of maize provides insight into e2024414118 Krüppel-like factor 6–mediated loss of BCAA its drive mechanism and evolution catabolism contributes to kidney injury in Nicolas Blavet, Hua Yang, Handong Su, Pavel Solansky´, mice and humans  Ryan N. Douglas, Miroslava Karafia´tova´, Lucie Simkova´, Sian E. Piret, Yiqing Guo, Ahmed A. Attallah, Sylvia J. Jing Zhang, Yalin Liu, Jie Hou, Xiaowen Shi, Chen Chen, Horne, Amy Zollman, Daniel Owusu, Justina Henein, Mohamed El-Walid, Morgan E. McCaw, Patrice S. Viktoriya S. Sidorenko, Monica P. Revelo, Takashi Albert, Zhi Gao, Changzeng Zhao, Gil Ben-Zvi, Lior  Hato, Avi Ma’ayan, John Cijiang He, Glick, Guy Kol, Jinghua Shi, Jan Vra´na, Hana Simkova´, and Sandeep K. Mallipattu Jonathan C. Lamb, Kathleen Newton, R. Kelly Dawe, Jaroslav Dolezel, Tieming Ji, Kobi Baruch, Jianlin Cheng, Fangpu Han, James A. Birchler, MICROBIOLOGY and Jan Bartos e2026598118 Iron robbery by intracellular pathogen via e2024785118 The Rhox gene cluster suppresses germline bacterial effector–induced ferritinophagy LINE1 transposition Yan, Wenqing Zhang, Mingqun Lin, Omid Kun Tan, Matthew E. Kim, Hye-Won , David Teymournejad, Khemraj Budachetri, Jeffrey Lakritz, Skarbrevik, Eric Babajanian, Tracy A. Bedrosian, and Yasuko Rikihisa Fred H. Gage, and Miles F. Wilkinson e2024202118 The ORF8 protein of SARS-CoV-2 mediates IMMUNOLOGY AND INFLAMMATION immune evasion through down- regulating MHC-Ι e2025718118 Mitochondria-dependent synthetic small- Yiwen Zhang, Yingshi Chen, Yuzhuang Li, Feng Huang, molecule vaccine adjuvants for Baohong Luo, Yaochang Yuan, Baijin Xia, Xiancai Ma, influenza virus infection Tao Yang, Fei Yu, Jun Liu, Bingfeng Liu, Zheng Song, Fumi Sato-Kaneko, Shiyin Yao, Fitzgerald S. Lao, Jingliang Chen, Shumei Yan, Liyang Wu, Ting Pan, Xu Jason Nan, Jonathan Shpigelman, Annette Cheng, Zhang, Rong Li, Wenjing Huang, Xin He, Fei Xiao, Tetsuya Saito, Karen Messer, Minya Pu, Nikunj M. Junsong Zhang, and Hui Zhang Shukla, Howard B. Cottam, Michael Chan, Anthony J. Molina, Maripat Corr, Tomoko Hayashi, e2026595118 A combination of Class-I fumarases and metabolites and Dennis A. Carson (α-ketoglutarate and fumarate) signal the DNA damage response in Escherichia coli e2026752118 Differential immune imprinting by influenza Yardena Silas, Esti Singer, Koyeli Das, Norbert virus vaccination and infection in Lehming, and Ophry Pines nonhuman primates Kevin R. McCarthy, Tarra A. Von Holle, Laura L. e2017046118 NAD(H)-mediated tetramerization controls Sutherland, Thomas H. Oguin III, Gregory D. Sempowski, the activity of Legionella pneumophila Stephen C. Harrison, and M. Anthony Moody phospholipase PlaB e2100588118 Structures suggest an approach for converting Maurice Diwo, Wiebke Michel, Philipp Aurass, Katja Kuhle-Keindorf, Jan Pippel, Joern Krausze, Sabrina weak self-peptide tumor antigens into Wamp, Christina Lang, Wulf Blankenfeldt, superagonists for CD8 T cells in cancer and Antje Flieger Pengcheng Wei, Kimberly R. Jordan, Jonathan D. Buhrman, Jun Lei, Hexiang Deng, Philippa Marrack, e2023202118 A catalog of tens of thousands of viruses from Shaodong Dai, John W. Kappler, Jill E. Slansky, and Lei Yin human metagenomes reveals hidden associations with chronic diseases e2025631118 TP53 missense mutations in PDAC are Michael J. Tisza and Christopher B. Buck associated with enhanced fibrosis and an immunosuppressive microenvironment e2006482118 Genetic and molecular determinants of Martino Maddalena, Giuseppe Mallel, Nishanth Belugali polymicrobial interactions in Nataraj, Michal Shreberk-Shaked, Ori Hassin, Fusobacterium nucleatum Saptaparna Mukherjee, Sharathchandra Arandkar, Ron Chenggang Wu, Yi-Wei Chen, Matthew Scheible, Rotkopf, Abby Kapsack, Giuseppina Lambiase, Bianca Chungyu Chang, Manuel Wittchen, Ju Huck Lee, Pellegrino, Eyal Ben-Isaac, Ofra Golani, Yoseph Truc T. Luong, Bethany L. Tiner, Andreas Tauch, Asis Addadi, Emma Hajaj, Raya Eilam, Ravid Straussman, Das, and Hung Ton-That Yosef Yarden, Michal Lotem, and Moshe Oren e2026354118 A phage mechanism for selective nicking of low low + e2103730118 Critical role of the CD44 CD62L CD8 T dUMP-containing DNA cell subset in restoring antitumor immunity Tridib Mahata, Shahar Molshanski-Mor, Moran G. Goren, in aged mice Biswanath Jana, Miriam Kohen-Manor, Ido Yosef, Oren Yuka Nakajima, Kenji Chamoto, Takuma Oura, Avram, Tal Pupko, Dor Salomon, and Udi Qimron and Tasuku Honjo e2025452118 High-resolution asymmetric structure of e2105747118 cGAS restricts colon cancer development by a Fab–virus complex reveals overlap protecting intestinal barrier integrity with the receptor binding site Shuiqing Hu, Yan Fang, Xiang Chen, Tianlei Cheng, Daniel J. Goetschius, Samantha R. Hartmann, Lindsey J. Miaoqing Zhao, Mingjian Du, Tuo Li, Minghao Li, Organtini, Heather Callaway, Kai Huang, Carol M. Bator, Zhiqun Zeng, Yonglong Wei, Zhimin Gu, Conggang Robert E. Ashley, Alexander M. Makhov, James F. Zhang, Lijun Sun, and Zhijian J. Chen Conway, Colin R. Parrish, and Susan L. Hafenstein

Contents PNAS u June 8, 2021 u vol. 118 u no. 23 u vii Downloaded by guest on September 24, 2021 NEUROSCIENCE PHYSIOLOGY e2101826118 The relationship between birth timing, circuit e2008276118 A minimally disruptive method for measuring wiring, and physiological response properties water potential in planta using of cerebellar granule cells hydrogel nanoreporters S. Andrew Shuster, Mark J. Wagner, Nathan Pan-Doh, Piyush Jain, Weizhen Liu, Siyu Zhu, Christine Yao-Yun Jing Ren, Sophie M. Grutzner, Kevin T. Beier, Tony Chang, Jeff Melkonian, Fulton E. Rockwell, Duke Hyun Kim, Mark J. Schnitzer, and Liqun Luo Pauli, Ying Sun, Warren R. Zipfel, N. Michele e2100126118 Optics and neural adaptation jointly limit Holbrook, Susan Jean Riha, Michael A. Gore, and Abraham D. Stroock human stereovision Cherlyn J. Ng, Randolph Blake, Martin S. Banks, Duje e2025013118 LRRC8A-containing chloride channel is crucial Tadin, and Geunyoung Yoon for cell volume recovery and survival under e2018188118 Neurophysiological coordination of hypertonic conditions duet singing Selma A. Serra, Predrag Stojakovic, Ramon Amat, Fanny Rubio-Moscardo, Pablo Latorre, Gerhard Melissa J. Coleman, Nancy F. Day, Pamela Seisenbacher, David Canadell, Rene´Bo¨ttcher, Michael Rivera-Parra, and Eric S. Fortune Aregger, Jason Moffat, Eula`lia de Nadal, Miguel A. e2020098118 Glia-derived temporal signals orchestrate Valverde, and Francesc Posas neurogenesis in the Drosophila e2100164118 Structure and function at the lipid–protein mushroom body interface of a pentameric ligand-gated Mengying Yang, Honglei Wang, Changyan Chen, ion channel Shiping Zhang, Mengxiao Wang, Bhagyashree Pramod Kumar, Gisela D. Cymes, Senapati, Shuhua Li, Shuanglong Yi, Linfang Wang, and Claudio Grosman Min Zhang, Shuai Yin, Yijing He, Lei Xue, Suewei Lin, and Margaret S. Ho e2023750118 Dopaminergic neuromodulation of prefrontal PLANT BIOLOGY cortex activity requires the NMDA receptor e2125016118 CRISPR-based targeting of DNA methylation coagonist D-serine in Arabidopsis thaliana by a bacterial CG- Glenn Dalle´rac, Xia Li, Pierre Lecouflet, Nade`ge specific DNA methyltransferase Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Basudev Ghoshal, Colette L. Picard, Brandon Vong, Brigitte Potier, David J. G. Watson, Staffan Schmidt, Suhua Feng, and Steven E. Jacobsen Gre´goire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T. Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, PSYCHOLOGICAL AND COGNITIVE SCIENCES Kevin C. Fone, Alain M. Gardier, Thomas e2102242118 Reactivation-induced motor skill learning Freret, Angelo Contarino, Mark J. Millan, Jasmine Herszage, Haggai Sharon, and Jean-Pierre Mothet and Nitzan Censor e2022288118 Segregation, integration, and balance of e2012941118 Attention bias modification in drug addiction: large-scale resting brain networks configure Enhancing control of subsequent habits different cognitive abilities Muhammad A. Parvaz, Pias Malaker, Anna Rong Wang, Mianxin Liu, Xinhong Cheng, Ying Wu, Zilverstand, Scott J. Moeller, Nelly Alia-Klein, Andrea Hildebrandt, and Changsong Zhou and Rita Z. Goldstein e2004685118 Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila CORRECTIONS Justin S. Rosenthal, Jun Yin, Jingce Lei, Anupama Sathyamurthy, Jacob Short, Caixia Long, Emma ANTHROPOLOGY Spillman, Chengyu Sheng, and Quan Yuan e2108115118 Biomechanical trade-offs in the pelvic e2022134118 Neural basis of opioid-induced respiratory floor constrain the evolution of the depression and its rescue human birth canal Shijia Liu, Dong-Il Kim, Tae Gyu Oh, Gerald M. Pao, Ekaterina Stansfield, Krishna Kumar, Philipp Jong-Hyun Kim, Richard D. Palmiter, Matthew R. Mitteroecker, and Nicole D. S. Grunstra Banghart, Kuo-Fen Lee, Ronald M. Evans, and Sung Han

PHARMACOLOGY PLANT BIOLOGY e2101119118 Visualization of β-adrenergic receptor e2106367118 Abscisic acid regulates secondary cell-wall dynamics and differential localization formation and lignin deposition in in cardiomyocytes Arabidopsis thaliana through Marc Bathe-Peters, Philipp Gmach, Horst-Holger Boltz, phosphorylation of NST1 Ju¨rgen Einsiedel, Michael Gotthardt, Harald Hu¨bner, Chang Liu, Hasi Yu, Xiaolan Rao, Laigeng Li, Peter Gmeiner, Martin J. Lohse, and Paolo Annibale and Richard A. Dixon

viii u www.pnas.org Contents Downloaded by guest on September 24, 2021