PBRC2006-07Scireport.Pdf
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“Through the maturing effects of time, the fertile roots of our research bear even more nutritious fruit for the benefit of Louisiana and humankind.” George Bray, M.D. former Executive Director Pennington Biomedical Research Center “Given the growth experienced by the Pennington Biomedical Research Center during the relatively short time it has been operational, we can predict that it will become one of the premier research institutions in the country.” Claude Bouchard, Ph.D. Executive Director Pennington Biomedical Research Center INsideCoverArt4.indd 1 3/19/08 1:00:49 PM TABLE OF CONTENTS 1 Foreword .............................................................................. 3 Autonomic Neuroscience Laboratory ........................................... 76 Message from the Executive Director ............................. 4 Blood-Brain Barrier Laboratory — I ............................................ 77 Blood-Brain Barrier Laboratory — II .......................................... 78 Vision 2010 — A Status Report ......................................... 9 Neurobehavior Laboratory .......................................................... 79 Two Decades of Discovery ......................................... 12-25 Neurobiology and Nutrition Laboratory — I ................................ 80 Remembering “Doc” ................................................................... 13 Neurobiology and Nutrition Laboratory — II .............................. 81 “The Biggest and Best Nutrition Research Center” ....................... 14 Neurosignaling Laboratory ......................................................... 82 Timeline ..................................................................................... 16 Neurotrauma and Nutrition Laboratory ..................................... 83 Twenty Years of Community Support ...................... 28-31 Nutritional Neuroscience and Aging Laboratory ......................... 84 Pennington Medical Foundation ................................................. 28 Adipocyte Signaling Laboratory .................................................. 85 Pennington Biomedical Research Center ....................................... 30 Endocrinology Laboratory ........................................................... 86 Status of Research Programs ...................................... 32-46 John C. McIlhenny Skeletal Muscle Physiology Laboratory ........... 87 Nuclear Receptor Biology Laboratory .......................................... 88 BASIC ResearcH .................................................................................. 33 Protein Structural Biology ........................................................... 89 Division of Experimental Obesity ................................................ 35 Maternal Biology ........................................................................ 90 Division of Functional Foods ...................................................... 37 Epigenetics and Nuclear Reprogramming Laboratory ................... 91 Division of Nutrition and the Brain ........................................... 39 Regenerative Biology Laboratory ................................................. 92 CLINIcaL ResearcH ......................................................................... 40 Stem Cell Biology Laboratory ...................................................... 93 Division of Clinical Obesity and the Metabolic Syndrome ............ 42 Ubiquitin Biology Laboratory ..................................................... 94 Division of Nutrition and Chronic Diseases ............................... 43 Clinical Research Unit Reports ............................... 96-106 Division of Health and Performance Enhancement (HaPE) ........ 45 POPULatION SCIENCE ..................................................................... 46 Behavorial Medicine Laboratory ................................................. 98 Division of Education ................................................ 48-50 Health Psychology Laboratory ..................................................... 99 Woman’s Health, Eating Behavior and Centers of Excellence ................................................. 52-57 Smoking Cessation Program ...................................................... 100 Clinical Nutrition Research Unit ................................................. 53 Ingestive Behavior Laboratory ................................................... 101 Center for Botanicals and Metabolic Syndrome ........................... 55 Exercise Biology Laboratory ...................................................... 102 COBRE - Center of Biomedical Research Excellence .................... 57 Human Physiology Laboratory .................................................. 103 Basic Research Laboratory Reports .......................... 58-94 Preventive Medicine Laboratory ................................................ 104 DNA Damage and Repair Laboratory ....................................... 60 Diet, Physical Activity and Behavior Modification Trials .......... 105 The William Hansel Cancer Prevention Laboratory ..................... 61 Pharmacology-Based Clinical Trials .......................................... 106 Antioxidant and Gene Regulation Laboratory ............................. 62 Population Science Laboratory Reports .............. 108-113 John C. McIlhenny Botanical Research Laboratory ...................... 63 Chronic Disease Epidemiology and Health Delivery ................... 110 Mechanisms of Diabetes Complications Laboratory ..................... 64 Clinical Epidemiology ............................................................... 111 Gene-Nutrient Interactions Laboratory ........................................ 65 Nutritional Epidemiology ......................................................... 112 Dietary Obesity Laboratory ......................................................... 66 Physical Activity Epidemiology Laboratory ................................ 113 Functional Genomics Laboratory ................................................ 67 Core Services ........................................................... 114-125 Infection and Obesity Laboratory ................................................. 68 BASIC RESEARCH CORES ........................................................... 115-118 Neuroendocrine Immunology Laboratory .................................... 69 Animal Metabolism and Behavior ............................................ 115 Energy Balance ........................................................................... 70 Cell Biology and Cell Imaging ................................................... 115 Human Genomics Laboratory ..................................................... 71 Cell Culture .............................................................................. 116 Molecular Genetics and Thermogenesis Laboratory ...................... 72 Comparative Biology ................................................................ 116 Neuropeptides Laboratory ........................................................... 73 Genomics Facility ...................................................................... 117 Regulation of Gene Expression ..................................................... 74 Proteomics ................................................................................ 117 Taste Genetics Laboratory ............................................................ 75 Transgenic ................................................................................. 118 (Continued on the next page) LOUISIANA STATE UNIVERSITY SYSTEM 2 2006-2007 SCIENTIFIC REPORT CLINICAL RESEARCH CORES .................................................. 118-125 Biostatistics and Data Management .......................................... 118 Clinical Chemistry .................................................................... 119 Dietary Assessment and Food Analysis ..................................... 120 Exercise Testing ......................................................................... 120 Imaging .................................................................................... 121 Inpatient Unit ........................................................................... 121 Library and Information Center ................................................ 122 Mass Spectrometry .................................................................... 122 Metabolic Chambers ................................................................. 123 Outpatient Clinic ...................................................................... 124 Recruitment .............................................................................. 125 Research Kitchen ....................................................................... 125 Administrative Services and Finance ................... 126-134 Message from the Associate Executive Director for Administration and Finance ................................................ 127 Communications ...................................................................... 129 Computing Services ................................................................... 130 Facilities Management .............................................................. 131 Fiscal Operations ...................................................................... 132 Human Resource Management ................................................. 132 Intellectual Property, Legal and Regulatory Affairs ..................... 133 Sponsored Projects