Chronic Traumatic Encephalopathy (CTE): Clinical and Pathological Insights Domenic P. Esposito MD

Introduction Results Introduction: Chronic Traumatic Encephalopathy (CTE) is a progressive Results:Analysis of pertinent historical events, results of neurological degenerative disease of the brain found in athletes and military veterans examination, clinical mental status testing, detailed neuropsychological with a history of repetitive brain trauma, including symptomatic concussions scoring on the 50 + subjects will be presented as well as the as well as asymptomatic subconcussive hits to the head. The diagnosis, at neuropathological results on 2 overlapping subjects. Pathological grading of this time, can only be made by post-mortem examination of brain and is the 96 players examined at autopsy will also be reviewed and coorelated based on the presence of hyperphosphorylated with clinical grading of the 50+ patients evaluated clinically andneurofibrillary tangles around small blood vessels at the depths of the cortical sulci.. . Originally, CTE was thought to only occur in boxers Conclusions however recent research has shown that other athletes, such as American Conclusion: The constellation of neurological, neuropsychological and football players, are at risk for the disorder. The diagnosis of CTE was first pathological findings found in this large cohort of former reported by Dr. Bennet Omalu in 2005..Dr Ann McKee and researchers at players and the neuropathological findings i will be discussed Boston University have reported to date on 92 of 96 former NFL players diagnosed with CTE. Clinical symptoms of CTE include memory loss, Learning Objectives confusion, impaired judgment, impulse control problems, aggression, To attempt to better understand CTE depression, and, eventually, progressive dementia [Default Poster] Methods Methods: This presentation will concentrate on the clinical evaluation of 50+ former NFL players with suspected CTE 2 of whom were also evaluated post mortem by Dr. Ann McKee and researchers at Boston University . All subjects provided detailed general medical, concussion and sub concussive event, and sports medicine histories. All subjects underwent detailed neurological examinations including mini-mental status exams, clinical dementia rating scores, and extensive neuropsychological testing. Post- mortem neuropathological examinations were performed on 2 subjects