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Product Catalog Compounding

Product Catalog Compounding

PRODUCT CATALOG COMPOUNDING

www.Humco.com +1 (855) 925-4736 CONTENTS

HUMCO GLOBAL HEADQUARTERS REMIT PAYMENTS TO ABOUT HUMCO 4 201 West 5th Street 7400 Alumax Drive Floor 12 Texarkana, TX 75501 HUMCO COMPOUNDING 5 Austin, TX 78701 PRODUCT LIST 6 SHIPPING - FREE ACTIVE PHARMACEUTICAL INGREDIENTS 8 PHONE & FAX UPS Ground Service is free for DTP +1 (855) 925-4736 - toll free (Direct-to-Pharmacy) accounts on orders VALIDATED STABILITY STUDIES 10 +1 (512) 474-7400 of more than $100 and weighing less than +1 (512) 474-7414 - fax 200 pounds in the lower 48 states. For CREAMS & LOTIONS 12 orders less than $100, shipping charges based on weight will apply. GEL BASES & OINTMENTS 33 EMAIL BULK COMPOUNDING DRUG SUBSTANCES 37 [email protected] Excludes hazardous materials, oversized (larger than 84”) items, drop shipped, and PRE-MIXED EXCIPIENT BASES 40 any items requiring special handling. ONLINE ORDERING ORAL VEHICLES 41 www.Humco.com ALASKA & HAWAII US published rate MISCELLANEOUS INGREDIENTS 47

PROFESSIONAL SERVICE HOURS HAZARDOUS MATERIALS Monday-Friday, 8:30 AM - 5:30 PM Per package fee of $25 in addition to air or Central Standard Time ground shipping charge.

CONTACT PHARMACEUTICAL RESOURCE BACK ORDERS CENTER & CUSTOMER SERVICE We will notify you if any items are un- +1 (855) 925-4736 - toll free available to ship. All back orders will be +1 (512) 474-7400 shipped free, UPS 3 day service, unless [email protected] otherwise specified. • Formulation questions • Stability testing & BUD data • Penetration studies MSDS & BUD STUDIES • Request a sample Available online at www.Humco.com • Certificate of Analysis

2 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 3 ABOUT HUMCO HUMCO COMPOUNDING

Humco, founded in 1872, is a Humco’s leading team of pro- Humco proudly manufactures and topical creams and gels to oral syr- diversified global pharmaceutical fessionals have strong expertise distributes a diversified line of phar- ups and suspensions. Our products company. Humco is focused on ranging from product development maceutical products. We focus on are designed to provide an optimal developing, manufacturing to commercialization in the Com- developing products that offer dynam- delivery system for a variety of formu- and commercializing inn- pany’s state-of-the-art FDA regis- ic solutions and help to fulfill unmet lations based on the desired route of ovative pharmaceuticals tered, cGMP compliant facilities. patient and pharmacist needs. administration and therapeutic intent. and high-quality over-the- Humco’s delivery vehicles are tailored counter (OTC) medicines With a presence in ap- Humco has a vast por- to meet pharmacist’s non-sterile com- for patients around the proximately 20 coun- tfolio of pharmaceuti- pounding needs while reducing the world. tries, Humco is com- cals that aid in impera- compounding preparation time OUR mitted to working tive solutions across and improving therapeutic out- With headquarters in with pharmacists, several key therapeutic comes for patients. APPROACH: Austin, TX, Humco serves physicians, healthcare categories including: •We can be counted on over 45,000 pharmacies providers and patients In addition to our delivery ve- through its Pharmaceutical to deliver innovative • Pain Management hicles, Humco offers an ex- •We get the job done Segment and its Consumer OTC and meaningful treat- • Infectious Disease tensive selection of Active •We take responsibility Products franchise. The Company ments that help peo- • Hormone Replacement Pharmaceutical Ingredients •We find a better way is anchored by its leading non-ster- ple around the world Therapy (“APIs”) that are conveniently pack- •We succeed as a team ile compounding delivery vehicles, live longer, healthier lives. • Wound Care aged in a variety of sizes to effectively including topical and transdermal • Dermatology and Aesthetics accommodate the needs of pharma- creams, syrups and suspensions. cists, hospitals, and pharmaceutical Humco also serves consumers Humco has established a leading companies. through its established and diverse reputation for developing, manufac- Consumer OTC Products business turing, and commercializing a diversi- of over 160 items with product fied line of non-sterile topical and oral placement in all major drug, food, pharmaceutical compounding delivery and mass-market retail chains, vehicles. Our patented compounding along with independent, locally products range from ready-to-use owned pharmacies.

4 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 5 Our compounding bases and vehicles are ready-made with wetting agents already incorporated into the base. Most formulations will not require any additional TOPICAL BASES & VEHICLES wetting or milling; greatly reducing the compounding preparation time. CREAMS & LOTIONS ORAL VEHICLES Anhydrous Base™ Item No. Size Price Item No. Size Price Buffer Cream™ Item No. Size Price Sorbitol Solution Item No. Size Price 6013-01 1 lb $50.00 Sanare Advanced™ 0112-56 500 g $307.20 3926-01 1 lb $28.60 3913-16 16 oz $4.96 VERSATILE TOPICAL CREAM SCAR THERAPY BASE BUFFERING AGENT FOR ORAL 70% USP SYRUP 0112-59 2500 g $1372.80 SUSPENSIONS 0112-31 5800 g $2825.00 GENEDERM™ Item No. Size Price Item No. Size Price Syrpalta (Red) Item No. Size Price 6026-56 500 g $500.00 Cherry Syrup™ 2662-16 16 oz $9.30 3920-16 16 oz $12.04 DERMATOLOGICAL 6026-57 4500 g $4500.00 SYRUP VEHICLE SYRUP VEHICLE TOPICAL CREAM GEL BASES & OINTMENTS 2662-28 1 gal $56.00 Item No. Size Price Item No. Size Price Item No. Size Price Lavare™ Item No. Size Price Syrpalta (No Color) 3927-16 16 oz $12.64 HRT Botanical™ 6001-01 1 lb $38.00 7001-62 100 g $166.40 Flavor Blend™ SYRUP VEHICLE HORMONE THERAPY WOUND WASH GEL 0089-16 16 oz $9.55 6001-79 10 lb $240.00 7001-56 500 g $661.60 SYRUP & SUSPENDING VEHICLE TOPICAL CREAM 0089-28 1 gal $62.00 7001-59 2500 g $2870.40 Versa Free™ Item No. Size Price Item No. Size Price 0125-16 16 oz $10.47 Item No. Size Price Item No. Size Price SYRUP VEHICLE HRT Heavy™ 6002-01 1 lb $38.00 PLO20 Flowable™ Flavor Plus™ 0125-28 1 gal $75.00 HORMONE THERAPY 0135-01 1 lb $65.00 0091-16 16 oz $9.55 6002-79 10 lb $240.00 VERSATILE TOPICAL LIGHT CREAM SUSPENDING VEHICLE TOPICAL CREAM 0091-28 1 gal $62.00 6002-81 40 lb $660.00 Item No. Size Price Item No. Size Price Versa Plus™ 0126-16 16 oz $10.47 PLO20 6008-01 1 lb $50.00 SUSPENDING VEHICLE Item No. Size Price Item No. Size Price 0126-28 1 gal $75.00 Liposomal Heavy™ Non-Flowable™ 6008-79 10 lb $365.00 6004-01 1 lb $50.00 Flavor Sweet-SF™ 0094-16 16 oz $9.55 VERSATILE TOPICAL CREAM VERSATILE TOPICAL CREAM 6008-81 40 lb $1310.00 SYRUP VEHICLE 6004-79 10 lb $365.00 0094-28 1 gal $62.00 6004-81 40 lb $1310.00 Item No. Size Price Item No. Size Price Universal Water Item No. Size Price Liposomal Regular™ 6003-01 1 lb $50.00 6017-01 1 lb $21.00 Flavor Sweet™ VERSATILE TOPICAL CREAM 0090-16 16 oz $9.55 6003-79 10 lb $365.00 Gel™ 6017-79 10 lb $165.00 SYRUP VEHICLE VERSATILE TOPICAL GEL 0090-28 1 gal $62.00 *Prices are current at time of printing-September 6003-81 40 lb $1310.00 2016, however, pricing and specifications are Item No. Size Price BULK COMPOUNDING DRUG Item No. Size Price subject to change without notice. Please contact Multibase™ 6015-01 1 lb $45.00 -AF™ VERSATILE TOPICAL CREAM 6050-98 8 oz $9.74 the Resource Center or visit the website for updated 6015-79 10 lb $380.00 SUBSTANCES FREE pricing. 6015-81 40 lb $1400.00 MOUTHWASH BASE Sodium Item No. Size Price PENcream™ Item No. Size Price 6120-59 2500 g Call for Item No. Size Price 6010-01 1 lb $25.00 3% Cream Pricing Mouthwash-GP™ VERSATILE TOPICAL CREAM 6030-98 8 oz $9.74 6010-79 10 lb $250.00 TOPICAL CREAM GENERAL PURPOSE 6010-81 40 lb $1000.00 MOUTHWASH BASE Item No. Size Price -Prilo- 6110-31 5800 g Call for Item No. Size Price Item No. Size Price RECURA™ 6020-56 500 g $1000.00 caine Cream, USP 6110-58 18000 g Pricing Mouthwash-OM™ TOPICAL CREAM 6040-98 8 oz $9.74 6020-59 2500 g $5000.00 TOPICAL CREAM MOUTHWASH BASE FOR ORAL MUCOSITIS BULK PRICING AVAILABLE Item No. Size Price Item No. Size Price Lidocaine 5% Contact us for pricing on bulk quantities SALTSTABLE LO™ 6130-59 2500 g Call for 6009-01 1 lb $70.00 Ointment, USP Item No. Size Price PAIN MANAGEMENT Pricing 6009-79 10 lb $450.00 TOPICAL OINTMENT Raspberry Syrup +1 (855) 925-4736 TOPICAL CREAM 2664-16 16 oz $9.83 6009-81 40 lb $1600.00 SYRUP VEHICLE

Item No. Size Price PRE-MIXED EXCIPIENT BLENDS Item No. Size Price SALTSTABLE LS 6021-56 500 g $90.00 Item No. Size Price Simple Syrup 2661-16 16 oz $8.42 ADVANCED™ 6021-57 4500 g $525.00 Emulsion 6016-94 4 oz $35.00 SYRUP VEHICLE PAIN MANAGEMENT 2661-28 1 gal $42.50 6021-58 18000 g $1890.00 Concentrate™ 6016-98 8 oz $57.00 TOPICAL CREAM 2661-75 5 gal $129.00 VISCOSITY ENHANCER 6016-28 1 gal $800.00 USP GUIDELINES It is the responsibility of the pharmacists to follow USP Guidelines on proper compounding procedures and techniques. Compounders should know and keep current on USP Chapter <795> and <1075>, which relate to non-sterile compounding. Its purpose is to help define good compounding practice and provide general information to enhance the compounder’s ability to compound preparations that are of acceptable strength, quality and purity.

6 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 7 ACTIVE PHARMACEUTICAL INGREDIENTS API Standards & Testing

Item No. Size Price Item No. Size Price Before Humco considers purchasing an API, we pre-qualify our suppliers to ensure that they manu- Amantadine 8058-19 25 g $30.00 , USP 8036-19 25 g $119.00 facture the API under current Good Manufacturing Practices, as expected in ICH Q7A requirements. Hydrochloride, USP 8058-62 100 g $100.00 8036-62 100 g $305.00 8058-43 1000 g $585.00 Once the API is received, a statistical sample is taken and tested in our on-site laboratories. Through Item No. Size Price Item No. Size Price comprehensive and thorough testing, we ensure the identity of the API and that the potency meets 8048-19 25 g $35.00 8054-35 5 g $1695.00 the USP requirements and are comparable to the manufacturer’s CofA. Hydrochloride, USP 8048-62 100 g $105.00 Propionate, USP 8054-19 25 g $3900.00 8048-43 1000 g $599.00 (Micronized) We use qualified and calibrated state-of-the-art analytical equipment under the Laboratory Controls Item No. Size Price , USP Item No. Size Price delineated in 21 CFR 211. A few examples of these include: , USP 8032-62 100 g $275.00 8055-62 100 g $260.00 8032-43 1000 g $1150.00 8055-43 1000 g $550.00

Item No. Size Price , USP Item No. Size Price , USP 8049-62 100 g $15.00 8038-19 25 g $9.00 8049-43 1000 g $85.00 8038-62 100 g $14.00 8038-43 1000 g $65.00 • Fourier Transform Infrared Spectrophotometer (FTIR) Item No. Size Price Item No. Size Price Bupivacaine 8050-19 25 g $105.00 , USP 8056-62 100 g $55.00 8050-62 100 g $339.00 • Ultra Violet/Visible Light Spectrophotometer (UV/Vis) Hydrochloride, USP 8056-43 1000 g $385.00 8050-43 1000 g $1795.00 Item No. Size Price Lidocaine Item No. Size Price 8051-62 100 g $455.00 8040-19 25 g $11.00 • Identification by Chemical Reactions Hydrochloride, USP 8051-43 1000 g $1300.00 Hydrochloride, USP 8040-62 100 g $32.00 8040-43 1000 g $150.00 Diclofenac, USP Item No. Size Price • Identification by Flame 8052-62 100 g $65.00 Miconazole, USP Item No. Size Price 8052-43 1000 g $399.00 8041-19 25 g $39.00 8041-62 100 g $120.00 Item No. Size Price • High Pressure Liquid Chromatography (HPLC) 8059-19 25 g $22.00 Sodium, Item No. Size Price Hyclate, USP 8059-62 100 g $83.00 8043-19 25 g $14.00 8059-43 1000 g $490.00 USP 8043-62 100 g $29.00 • Gas Chromatograph (GC) , USP Item No. Size Price Item No. Size Price 8065-19 25 g $136.00 , USP 8063-62 100 g $135.00 (Micronized) (Micronized) 8065-62 100 g $460.00 8063-43 1000 g $685.00 • Thin Layer Chromatography

Item No. Size Price Item No. Size Price Estriol, USP 8066-19 25 g $504.00 (Micronized) 8064-19 25 g $18.00 8066-62 100 g $1394.00 Hydrochloride, USP 8064-62 100 g $61.00 • Titrations Estrone USP Item No. Size Price Item No. Size Price 8067-19 25 g $143.00 Tetracaine 8046-19 25 g $18.00 8067-62 100 g $328.00 Hydrochloride, USP 8046-62 100 g $59.00 8046-43 1000 g $425.00 Item No. Size Price , USP Humco is committed to adhering to the highest quality standards to ensure that our 8053-19 25 g $109.00 Item No. Size Price 8053-62 100 g $225.00 8057-19 25 g $27.00 products are consistently valued as the best option for patients and pharmacists. 8053-43 1000 g $790.00 Hydrochloride, USP 8057-62 100 g $86.00 8057-43 1000 g $699.00

8 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 9 VALIDATED STABILITY STUDIES The Beyond-Use-Date study evaluates the potency and stability of a formula over a course of time, from 30 days to 180 Active Ingredient HRT HRT Liposomal Liposomal Multi- PEN- PLO20 PLO20 RECURA SaltStable SaltStable Botanical Heavy Heavy Regular base cream Non-Flowable Flowable LO LS Advanced days. Below is an alphabetical listing of the API’s studied for stability with correlating bases used for the compounded preparations. Please note, strength depends on percentage of API used. See appropriate product page for details. 90 90

Active Ingredient HRT HRT Liposomal Liposomal Multi- PEN- PLO20 PLO20 RECURA SaltStable SaltStable 90 90 Botanical Heavy Heavy Regular base cream Non-Flowable Flowable LO LS Advanced Progesterone 180 180 180

Amitriptyline HCl 90 Promethazine 90 90 90 90

Baclofen 90 180 180 180

Benzocaine 90 Tetracaine HCl 90 90

Bupivacaine HCl 90 Verapamil HCl 90 90 Active Ingredient Flavor Flavor Flavor Versa Versa HCl 90 90 Blend Sweet/SF Plus Free Plus Cyclobenzaprine HCl 90 90 Acetazolamide 60 60 90 Allopurinol 60 60 90 60 60 Diclofenac 90 HCl 91 91 Diclofenac Na 90 Besylate 91 91 90 90 Atenolol 60 60 HCl 90 Captopril 14 14 Estradiol 90 150 HCl 60 60 Estriol 120 180 Chloroquine HCl 60 60 Estrone 150 120 Cisapride 60 60 Fluconazole 180 91 91 HCl 90 90 Diltiazem HCl 60 60 90 90 Flurbiprofen 90 Dipyridamole 60 60 Gabapentin 90 90 90 90 90 90 Enalapril Maleate 60 60 Haloperidol 90 90 Acetate 60 60 90 HCl 60 60 Ibuprofen 90 60 90 90 Hydralazine HCl 92 92 HCl 90 60 60 Ketoprofen 90 90 90 90 60 60 Lactic Acid 90 91 91 Lidocaine 90 90 90 Metolazone 60 60 Lidocaine HCl 90 Metoprolol Tartrate 60 60 Menthol 90 91 91 Methimazole 90 90 90 90 Procainamide HCl 60 60 90 Pyrazinamide 60 60 Metoclopramide 90 Sulfate 60 60 90 90 90 90 Rifampin 28 28 Miconazole 180 Sildenafil Citrate 91 91 Pentoxifylline 90 60 60 Phenytoin 90 90 28 28 90 60 60 Verapamil HCl 60 60

10 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 11 CreamsWound Creams & & LotionsScar ANHYDROUS BASE™ GENEDERM™ Lotions VERSATILE TOPICAL CREAM DERMATOLOGICAL BASE FOR WRINKLES

Item No. NDC No. Size Price Item No. NDC No. Size Price 6013-01 00395-6013-01 1 lb $50.00 Humco’s Anhydrous Base™ is designed for low-load hydrophilic and GENEDERM™ provides a firming effect on the skin - tightening and 6026-56 00395-6026-56 500 g $500.00 high-load lipophilic actives that are unstable in water. Intense studies smoothing fine lines and wrinkles. It is uniquely formulated with validate its compatibility with numerous drugs across a broad range Sodium Polystyrene Sulfonate, a film forming polymer that creates a of applications. It is cosmetically elegant with an exceptional sensory matrix and provides excellent binding to the skin, allowing the base to evaluation profile over other anhydrous bases, providing a smooth, adapt to changes in facial expressions and movement without cracking light, and silky feel. or peeling. GENEDERM™ can be used to reduce the appearance of fine lines and wrinkles. ANHYDROUS BASE™ BENEFITS: • Contains absolutely no water GENEDERM™ BENEFITS: Sensory • Non-greasy • Suitable for all skin types Evaluation Profile • Validated & proven drug compatibility • Comfortable - Allows skin to breathe • Cosmetically elegant – smooth, light, silky feel • Can be worn for 4-8 hours, including night-time application Common Actives of Anhydrous • Preservative-free & petroleum-free • Can be applied without API’s for wrinkle treatment in Wrinkle Care: • Easy to use – actives can be directly incorporated without wetting • Visible results after first application Base™ compared Vitamin E – 200IU/g • 180-day BUD with all API’s Antioxidant to reduce the signs of aging to other standard • Fragrance-free & dye-free and photo-aging anhydrous bases: – 2-10% (as Ascorbyl Palmitate) Humco’s base Antioxidant to reduce the signs of aging GENEDERM™ PROPERTIES is superior in all ANHYDROUS BASE™ PROPERTIES Specific Gravity 0.95 g/cm³ pH 5.0 - 6.0 Niacinamide – 2% areas - wetness, Viscosity 50,000 - 100,000 cps Stabilizing effect on epidermal Color Light Beige barrier function, seen as the reduction in trans-epidermal water loss absorbency, gloss Transdermal Penetration + + + Physical Format Light Cream & silkiness Hydrophilic 10% & Lipophilic 20% Color Opaque, Off-White Estradiol – 0.01% and Estriol 0.3% API Compatibility Total API Load - 20% Hydrophilic 10% & Lipophilic 10% After treatment for 6 months, elasticity API Compatibility and firmness of the skin had markedly Total API Load - 20% • Dermatology • HRT • Immunotherapy improved; wrinkle depth and pore Typical Applications • Pain Management • Sports Medicine Typical Applications • Dermatology • Wrinkles sized had decreased by 61-100%; skin • Veterinary Medicine • Wound Care moisture had increased and wrinkle depth decreased significantly

Alpha-Lipoic Acid – 5% SAMPLE FORMULAS: SAMPLE FORMULA: Twelve weeks treatment with a cream Anti Wrinkle: improves clinical characteristics related Glutathione 20% Topical Methimazole 5% Topical to photo-aging of facial skin Glutathione (L) Reduced 20% Methimazole 5% Alpha-Lipoic Acid 5% Anhydrous Base qs 100% Anhydrous Base qs 100% Ascorbyl Palmitate 2% Estriol Micro Powder 0.3% Recommended Penetration Enhancer: Recommended Wetting Agent: Niacinamide 2% Mixing Tips 50% Lecithin in Isopropyl Palmitate Emu Oil Tretinoin 0.025% Propylene Glycol 10% • Mixing Speed - 1000 rpm for 2-5 GENEDERM qs 100% minutes • If Dispensing in a Pump, Airless Pump Dispensers are Recommended

12 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 13 Clinical Study GENEDERM™ GENEDERM™ Dermatological Wrinkle Base has been proven to reduce or decrease five key parameters CLINICAL STUDY in relation to wrinkle reduction.

STUDY Evaluation of Key Parameters on Outer Parts of 30 Panelist's Eyes, In Vivo, Using Image Analysis "Product is non- In one of the most innovative research projects ever undertaken in medical aesthetics, ‘The Consumer Product Testing Company' irritating and captures the PRIMOS and VISIA image analysis, and opinions on wrinkle length, number, and area from 30 female subjects, ages reduces visibility 35 to 65, with mild to moderate crow's feet (coarse wrinkles) in the outer canthus eye area. The relative skin surface was ana- of fine lines... lyzed as a composite and as a single point in any plane thereby making it possible to examine and compare several cutaneous a small amount parameters. The outer parts of the eyes of thirty panelists were used to evaluate several key parameters over eight weeks. goes a long way… RESULTS easy to use… 'The Consumer Product Testing Company' key findings: skin feels soft, •. For women seeking aesthetic treatment, opinions found (89%) positive response for “softened line/wrinkles around eyes, (89%) smooth, refreshed positive response for “made skin feel firmer/tighter”, and (100%) positive response for “easy to use as daily skin care regimen”. and firm…it is not •. PRIMOS image analysis found (71%) of women with wrinkle greasy and has length decrease. • .VISIA image analysis found (82%) of women with wrinkle num- pleasant smell…it ber decrease and (79%) of women with wrinkle area decrease. felt high quality.”

Parameter Genederm® Roughness 14% Decrease "The evaluation of parameters indicates that the use of Genederm™ produced Residual Length 9% Decrease smoothing and restructuring of the skin’s surface after seven days of product Average Amplitude 10% Decrease application." Primary Wrinkle . 9% Decrease - Advanced Scientific Imaging Consulting, leading analytical laboratory Number of Peaks 10% Reduction >View Full Study at www.Humco.com 14 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 15 CreamsWound Creams & & LotionsScar HRT BOTANICAL™ HRT HEAVY™ Lotions CERTIFIED HYPOALLERGENIC HRT BASE HRT BASE WITH 180 DAY BUD

Item No. NDC No. Size Price Item No. NDC No. Size Price 6001-01 00395-6001-01 1 lb $38.00 HRT Botanical™ is an oil-in-water, light cream, certified hypoallergenic HRT Heavy™ is a heavier cream base than HRT Botanical™; it provides 6002-01 00395-6002-01 1 lb $38.00 6001-79 00395-6001-79 10 lb $240.00 base, with all natural ingredients and antioxidants. It has a lotion deeper skin penetration. It is specifically designed for male and 6002-79 00395-6002-79 10 lb $240.00 consistency and provides sustained skin penetration. Ideal for high female hormone restoration formulations and has a low to moderate 6002-81 00395-6002-81 40 lb $660.00 lipophilic API concentrations. API carrying capacity.

HRT BOTANICAL™ BENEFITS: HRT HEAVY™ BENEFITS: • Sustained skin penetration • Sustained skin penetration • Paraben-free & fragrance-free • Paraben-free • Natural ingredients & natural preservatives • Natural ingredients • Added antioxidants, botanicals, and herbal extracts • Cosmetically elegant • Certified hypoallergenic • Ideal for intra-vaginal preparations • Cosmetically elegant • Validated stability/potency of >90 days for all hormone APIs • Ideal for vaginal preparations

HRT BOTANICAL™ PROPERTIES HRT HEAVY™ PROPERTIES pH 6.5 pH 7.5 Specific Gravity 1.00 g/cm³ Specific Gravity 1.04 g/cm³ Viscosity 60,000 cps Viscosity 165,000 cps Physical Format Light Cream Physical Format Cream Color Light Beige Color White Transdermal Penetration + + Transdermal Penetration + + + API Compatibility Lipophilic - 20% API Compatibility Lipophilic - 20%

Typical Applications • Hormone Replacement Typical Applications • Hormone Replacement

Published Studies – Beyond-Use-Date (BUD) Published Studies – Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUD ACTIVE INGREDIENT BUD Estradiol – 1% – (Estriol, Estrone) 90 Days Estradiol – 1% – (Estriol, Estrone) 150 Days Estriol – 1% – (Estradiol, Estrone) 120 Days Estriol – 1% – (Estradiol, Estrone) 180 Days Estrone – 0.5% – (Estradiol, Estriol) 150 Days Estrone – 0.5% – (Estradiol, Estriol) 120 Days Prednisolone 5% 90 Days Metronidazole - 2% 90 Days Progesterone – 20% 180 Days Progesterone – 20% 180 Days Testosterone – 5% 180 Days Testosterone – 5% 180 Days

16 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 17 Transdermal PENcream™, Anhydrous Base™, Study 5% PROGESTERONE HRT Botanical™, and HRT Heavy™ PROGESTERONE Transdermal have been proven to transport Progesterone into Study and through human skin, performing significantly TRANSDERMAL STUDY more effectively than our competitor's base.

Study Results Evaluation of the Percutaneous Absorption of The data did indicate that Progesterone, In Vitro, Using the Epiderm Skin Model % Progesterone Permeation Through the Stratum Corneum progesterone penetrated into and The progesterone study evaluated the percutaneous absorption 1.60 through human epidermal Humco’s of progesterone in the following Humco 1.40 cultures, in vitro, from the test bases: HRT Botanical™, HRT Heavy™, Anhydrous Base™ and 1.20 formulations provided. The PENCream™. Absorption was measured in human epidermal 1.00 absorption profiles indicate a PENcream™, steady penetration to a peak flux cultures, in vitro, using the finite dose technique and Franz 0.80

% Permeation occurring at approximately 12 Diffusion Cells. 0.60 Anhydrous hours after dose application. HRT 0.40 Botanical™, HRT Heavy™, Formulas were tested on standardized sections for the percuta- 0.20 Base™, neous absorption of progesterone over a 12-hour dose period. Base Competitor’s Botanical™ HRT Heavy™ HRT Base™ Anhydrous ™ PENCream Anhydrous Base™, and 0.00 PENCream™ delivered more At pre-selected times after dose application, the dermal receptor Progesterone progesterone than our solution was completely removed and replaced with fresh recep- Competitor’s Base Humco's Anhydrous Base HRT Heavy™, HRT Botanical PENCream competitor's base. tor solutions; and an aliquot was saved for subsequent analysis. HRT Heavy Samples were analyzed for progesterone content by High and HRT Performance Liquid Chromatography (HPLC). The total percent of applied dose that penetrated past the stratum corneum with our competitor’s Botanical™ The in vitro human Epiderm skin model is a proven tool, valuable Progesterone Flux VS Time for the study of percutaneous absorption and determination of base is 20% less than Humco’s HRT Botanical™, HRT Heavy™, pharmacokinetics of topically applied drugs. The model uses 0.30 Competitor’s Base are Validated Anhydrous Base™, and human epidermal skin mounted in specially designed diffusion 0.25 HRT Botanical PENcream™. cells that allow the skin to be maintained at a temperature and 0.20 HRT Heavy Transdermal humidity that match typical in vitro conditions. A finite dose of Anhydrous Base formulation is applied to the outer skin surface, and drug ab- 0.15 PENCream Vehicles sorption is measured by monitoring the rate of appearance in 0.10

the receptor solution bathing the inner surface of the skin. Data (ug/cm2/hr) Flux 0.05 defining total absorption, as well as rate of absorption, can be 0.00 accurately determined in this model. 4 8 12 Time Transdermal Drug Absorption:

• Avoids hepatic first pass effect, reducing adverse reactions to certain drugs

• Reduces minor irritation and systemic toxicity • Helps avoid possible drug interactions with food and intestinal flora View Full Study at www.Humco.com • Can be applied to different parts of the body (site rotation) >

18 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 19 Creams Creams & & Lotions LIPOSOMAL HEAVY™ LIPOSOMAL REGULAR™ Lotions MOISTURIZING TRANSDERMAL TRANSDERMAL LIPOSOMAL BASE LIPOSOMAL BASE Item No. NDC No. Size Price Item No. NDC No. Size Price 6004-01 00395-6004-01 1 lb $50.00 Liposomal Regular™ and Liposomal Heavy™ are cosmetically elegant, 6003-01 00395-6003-01 1 lb $50.00 6004-79 00395-6004-79 10 lb $365.00 Liposomal Heavy™ is formulated with additional emulsifiers to allow liposomal transdermal bases with excellent skin penetration and mois- 6003-79 00395-6003-79 10 lb $365.00 6004-81 00395-6004-81 40 lb $1310.00 for higher API loads and solvent concentrations to be incorporated. turizing capabilities. They are formulated to incorporate lipophilic and 6003-81 00395-6003-81 40 lb $1310.00 Added emollients provide excellent moisturization—an ideal choice for hydrophilic actives and penetrate faster than HRT bases. dry and/or dehydrated skin.

LIPOSOMAL HEAVY™ AND LIPOSOMAL REGULAR™ BENEFITS: • Cosmetically elegant – excellent moisturizing effect Published Studies – Beyond-Use-Date (BUD) • Faster absorption & deeper penetration than HRT bases • API compatibility – virtually all actives • Natural preservatives ACTIVE INGREDIENT LIPOSOMAL REGULAR™ LIPOSOMAL HEAVY™ • Water & oil-soluble BUD BUD — • Ideal for cosmetic facial applications Dehydroepiandrosterone – 1.25% 90 Days • Paraben-free Dexamethasone – 1.5% – (Haloperidol, ) — 90 Days Diclofenac – 4% — 90 Days Diltiazem – 2% — 90 Days Estradiol – 0.5% – (Estriol) 60 Days — PROPERTIES LIPOSOMAL HEAVY™ LIPOSOMAL REGULAR™ Gabapentin – 6% — 90 Days pH 6.0 7.5 Gabapentin – 12.5% 90 Days — Specific Gravity 1.00 g/ml 1.00 g/ml Haloperidol – 0.1% – (Dexamethasone, Lorazepam) — 90 Days Viscosity 250,000 cps 120,000 cps Hydroquinone – 5% – (Glycolic Acid) — 90 Days Format Heavy Cream Light Cream Methimazole – 5% 90 Days — Color White Off-White Piroxicam – 0.5% — 90 Days Transdermal Penetration + + + + + + + Progesterone – 5% 90 Days — Hydrophilic – 10% Hydrophilic – 5% Promethazine – 5% — 90 Days API Compatibility Lipophilic – 10% Lipophilic – 5% Total API Load – 20% Total API Load – 10% • Dermatology • Dermatology Typical Applications • Pain Management • Pain Management • Immunotherapy • Hormone Therapy • Sports Medicine • Veterinary Medicine Mixing Tip • Higher API Loads • Lower API Loads • Recommended to Reduce Oxidation: Recommended Use • Dry/Dehydrated Skin • Cosmetic Preparations Sodium Bisulfite - 0.5% • Chemical Peels • Pigmentation Treatments

20 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 21 Creams Creams & & Lotions MULTIBASE™ PENCREAM™ Lotions HIGHLY VERSATILE OIL-IN-WATER CREAM TRANSDERMAL OIL-IN-WATER VANISHING BASE BASE Item No. NDC No. Size Price Item No. NDC No. Size Price 6015-01 00395-6015-01 1lb $45.00 6010-01 00395-6010-01 1 lb $25.00 6015-79 00395-6015-79 10 lb $380.00 A versatile, oil-in-water natural vanishing cream that uses oleosomic PENCream™ is an elegant oil-in-water vanishing cream formulated for 6010-79 00395-6010-79 10 lb $250.00 6015-81 00395-6015-81 40 lb $1400.00 6010-81 00395-6010-81 40 lb $1000.00 emulsifiers and penetration enhancers. It is a great oil-free moisturizing enhanced transdermal penetration. This elegant alternative to PLO, with base that provides natural skin penetration. MultiBase™ is designed added emollients, provides a better rub-in and longer-lasting moisturizing for both hydrophilic and lipophilic actives and exhibits superior stability effects without irritation. PENCream™ is highly compatible with a diverse in the presence of low and high pH, high salt, high ethanol, and high range of hydrophilic and lipophilic actives, has a high API load capacity, polar compounds, allowing for flexible compounding and formulation and is ideal for hybrid formulations. options. PENCREAM™ BENEFITS: SAMPLE FORMULA:

MULTIBASE™ BENEFITS: • Free of BHT, EDTA, parabens, and urea Pain Management Cream: Gabapentin 5% • Mineral oil-free, gluten-free, and propylene glycol-free • Enhanced penetration capability – efficacious API absorption Lidocaine 15% • Noncomedogenic • Hydrophilic & lipophilic compatibility – high loads Ketoprofen 10% Dimethyl 5% • Enhanced drug absorption & penetration • Natural ingredients – less irritation than PLO PENCream qs 100% • Ideal for vaginal preparations • Cosmetically elegant – lasting moisturizing effect • Stable over a broad range pH • Applies easily – no sticky residue • API compatibility – hydrophilic & lipophilic • Validated API compatibility • Natural ingredients – moisturizers derived from berries, grapes, Published Studies – Beyond-Use-Date (BUD) plums, and pears; emulsifiers derived from vegetable fatty acids & ACTIVE INGREDIENT BUD palm oil; thickening agents derived from coconut oil PENCREAM™ PROPERTIES Clomipramine HCl– 7.5% 90 Days pH 7.0 Fluoxetine HCl– 7.5% 90 Days Specific Gravity 0.96 g/cm³ Gabapentin – 6% – (Ketoprofen, Lidocaine) 90 Days Published Studies – Beyond-Use-Date (BUD) MULTIBASE™ PROPERTIES Viscosity 300,000 cps Ibuprofen – 10% 90 Days ACTIVE INGREDIENT BUD pH 7.0 Physical Format Heavy Cream Ketoprofen - 10% - (Gabapentin, Lidocaine) 90 Days Capsaicin – 1.2% – (Menthol, Methyl Salicylate) 90 Days Specific Gravity 0.90 g/cm³ Lactic Acid – 8.5% 90 Days Color White Lidocaine – 15% – (Gabapentin, Ketoprofen) 90 Days Viscosity 250,000 cps Lidocaine – 8% – (Metronidazole, Phenytoin) 90 Days Transdermal Penetration + + + + Methimazole – 7.5% 90 Days Physical Format Heavy Cream Menthol – 8% – (Capsaicin, Methyl Salicylate) 90 Days Hydrophilic & Lipophilic - Metoclopramide – 2% 90 Days API Compatibility Color White Total API Load - 30% Methyl Salicylate – 20% – (Capsaicin, Menthol) 90 Days Metronidazole – 3% 90 Days Transdermal Penetration + + • Pain Management Metronidazole – 8% – (Lidocaine, Phenytoin) 90 Days Promethazine – 5% 90 Days Hydrophilic 10% & Typical Applications • Veterinary Medicine • Immunotherapy Phenytoin – 8% – (Lidocaine, Metronidazole) 90 Days API Compatibility Lipophilic 20% Tetracaine HCl– 2% 90 Days Progesterone – 10% 180 Days Total API Load - 30% Testosterone - 2% 180 Days pH Compatibility 3.0 - 11.0 Salt Tolerance Salt Forms - 10% Mixing Tips SAMPLE FORMULAS: • Water Soluble Powders: Solvent Compatibility Polar & Non-Polar HRT Cream: Cream: Anti-Wrinkle Cream: Levigate with Alcohol, Dimethyl Solfoxide Progesterone 20% Capsicum Oleoresin 0.6% Retinoic Acid 0.05% Glycerin 10% Methyl Salicylate 10% Glycerin 10% • Hormone Replacement (DMSO), Glycerin, Polyethylene Glycol (PEG) 300 or Multibase qs 100% Menthol 4% Multibase qs 100% Typical Applications • Dermatology 400 or Purified Water Multibase qs 100% • Pain Management • Sports Medicine • Oil-Soluble Powders Can be Directly Incorporated

22 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 23 Creams Your Compounding Vehicle to help you Creams & & Lotions RECURA™ Lotions TOPICAL COMPOUNDING TOPICAL BASE FOR ANTIFUNGAL ACTIVES CREAM

Item No. NDC No. Size Price 6020-56 00395-6020-56 500 g $1000.00 RECURA™ topical cream is an innovative compounding delivery vehicle 6020-59 00395-6020-59 2500 g $5000.00 created for creams compounded to treat conditions such as onychomycosis. Utilizing penetration enhancers, RECURA™ provides good penetration into toenails, fingernails, and skin, works well with a variety of antifungal agents, and compounds easily. It has been intensively studied, patented, and peer-reviewed in order to validate the compatibility of the cream with a number of active ingredients. RECURA™ Peer Reviewed Study RECURA™ BENEFITS: • Penetration Ability - contains penetration enhancers and natural oils in IJPC Jan/Feb to facilitate active drug absorption • Drug Compatibility - both oil and water soluble powders can be 2016 Issue Pgs levigated with alcohol • Compound Diversity - contains penetrating agents for better 71-80 absorption, natural oils for better skin absorption, and is alcohol- dispersible for viscosity adjustment

RECURA™ PROPERTIES pH 7.0 - 9.0 Physical Format Viscous Cream Color Opaque, Light Lavender RECURA topical cream is an innovative Typical Applications Fungal treatment on toenails, fingernails, and skin compounding delivery vehicle created for ABOUT RECURA creams compounded to treat conditions • RECURA can be formulated to hold and help in the delivery of various such as onychomycosis. antifungal active ingredients • In Vitro testing in a novel nail model suggests the potential utility of Published Studies – Beyond-Use- SAMPLE FORMULAS: RECURA topical cream to enhance delivery of antifungal actives across Date (BUD) Nail Cream 1: Nail Cream 2: Skin Cream: the nail ACTIVE INGREDIENT BUD Miconazole 3 g Fluconazole 3 g 0.6 g RECURA 27 g RECURA 27 g Ibuprofen 0.6 g • Peer reviewed study1 in in vitro nail models comparing drug Fluconazole – 10% 180 Days RECURA 28.8 g absorption with RECURA vs. marketed prescription solutions Miconazole – 10% 180 Days Manufactured By: • RECURA is for topical use only and is not for oral, ophthalmic, or intravaginal use

Humco | 512 E 11th St, Ste 201, Austin, Texas 78701 - USA 1 Turner R et al., A Novel Vehicle for Enhanced Drug Delivery Across the Tel. (512)474-7400 | Fax (512)474-7414 Human Nail for the Treatment of Onychomycosis, INTL. J. PHARM. View Full Study at www.Humco.com [email protected] | www.Humco.com COMPOUNDING 2016;20(1):71-80 >

24 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 25 Creams Creams & SALTSTABLE LS & Lotions SALTSTABLE LO™ ADVANCED™ Lotions READY-TO-USE TRANSDERMAL PAIN BASE READY-TO-USE TRANSDERMAL PAIN BASE

Item No. NDC No. Size Price Item No. NDC No. Size Price 6009-01 00395-6009-01 1 lb $70.00 SaltStable LO™ is a ready-to-use transdermal cream base providing SaltStable LS Advanced™ is an extension and enhancement of SaltStable 6021-56 00395-6021-56 500 g $90.00 6009-79 00395-6009-79 10 lb $450.00 an elegant alternative to traditional PLOs. It’s uniquely designed for LO™. SaltStable LS Advanced™ is a scientifically advanced, extremely 6021-57 00395-6021-57 4500 g $525.00 6009-81 00395-6009-81 40 lb $1600.00 long shelf, temperature, and physical stability; it will not separate in durable, robust and versatile transdermal cream base formulated with 6021-58 00395-6021-58 18000 g $1890.00 the presence of high levels of ionic substances or when refrigerated. It a silogel that provides a smooth, silky dry feel. SSLS Advanced™ is uses emulsifiers and hydrocolloids that provide a chemical penetration designed for all actives and is non-specific to salt; it also exhibits superior enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmetically API carrying capacity (high loads) of multiple actives in one formulation. elegant and compatible with both hydrophilic and lipophilic APIs SaltStable LS Advanced™ demonstrates excellent stability without the allowing for compounding flexibility. need to add emulsifiers. SALTSTABLE LO™ BENEFITS: SALTSTABLE LS ADVANCED™ BENEFITS: • Efficacious active drug absorption • Increased stability with a high percent of APIs & multiple actives • Validated in vitro transdermal penetration & API compatibility • Validated in vitro transdermal vehicle up to 8 APIs in one formulation • Temperature stable & two-year shelf stable • Less sticky & less tacky because of silogel (silicone-based organogel) • Hydrophilic compatibility – high levels of ionic powders can be • Off-white, cosmetically elegant cream directly incorporated • API compatibility – compatible with all actives, non-specific ot salt • Lipophilic compatibility – moderate levels of oil-soluble powders • Time saving – ready-to-use base, no need for wetting or adding can be levigated with glycerin, propylene glycol, polyethylene glycol thickening agents (PEG) 300 or 400, or alcohol • Ideal for formulations with multiple actives & high API loads • Cosmetically elegant – not tacky or sticky

Published Studies – Beyond-Use-Date (BUD) Published Studies – Beyond-Use-Date (BUD) ACTIVE INGREDIENT BUD SALTSTABLE LO™ PROPERTIES SALTSTABLE LS ADVANCED™ PROPERTIES ACTIVE INGREDIENT BUD Amitriptyline HCl – 2% – (Lidocaine) 90 Days pH 7.0 pH 7.1 - 7.5 Baclofen – 2% 90 Days Benzocaine – 20% – (Lidocaine, Tetracaine) 90 Days Specific Gravity 1.00 g/cm³ Specific Gravity 0.90 g/cm³ Bupivacaine HCL – 1% 90 Days Clomipramine HCl– 5% 90 Days Viscosity 300,000 cps Viscosity 1,200,000 cps Cyclobenzaprine HCl– 2% 90 Days Cyclobenzaprine HCl – 2% 90 Days Physical Format Heavy Cream Physical Format Heavy Cream Diclofenac Na – 5% 90 Days Diphenhydramine HCl– 10% 90 Days Flurbiprofen – 10% 90 Days Color Light Beige Color Off White Fluoxetine HCl– 5% 90 Days Gabapentin – 10% 90 Days Transdermal Penetration + + + + Transdermal Penetration + + + + Gabapentin – 6% 90 Days Ibuprofen – 3% 90 Days Hydrophilic 35% & Hydrophilic 30% & Ketoprofen – 10% 90 Days API Compatibility Lipophilic 10% API Compatibility Lipophilic 40% Ketamine HCl – 10% 90 Days Total API Load - 35% Total API Load - 40% Lidocaine – 10% – (Benzocaine, Tetracaine) 90 Days Ketoprofen – 20% 90 Days • Pain Management • Pain Management Methimazole – 5% 90 Days Typical Applications • Veterinary Medicine Typical Applications • Veterinary Medicine Licocaine HCl – 5% 90 Days Metronidazole – 2% 90 Days • Sports Medicine • Sports Medicine Pentoxyfylline – 3% 90 Days Promethazine – 5% 90 Days Verapamil HCl– 10% 90 Days Tetracaine HCl– 4% – (Benzocaine, 90 Days Lidocaine)

26 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 27 Transdermal Creams Study SALTSTABLE LS Breakthrough Study: & ADVANCED™ SaltStable LS Advanced™ Lotions has been proven to deliver eight drugs TRANSDERMAL STUDY simultaneously through human skin in-vitro. STUDY RESULTS TESTED FORMULA Evaluation of the Percutaneous Absorption of Pentoxifylline + Humco’s SaltStable LS Ketamine HCl + Ibuprofen + Cyclobenzaprine HCl + Diclofenac Baclofen Flux VS Time Bupivacaine Flux VS Time Advanced™ compound- Baclofen...... 2% Na + Baclofen + Bupivacaine HCl + Gabapentin, In SaltStable 0.030 0.15 ing base is a proven Bupivacaine...... 1% SaltStable LS SaltStable LS LS Advanced™, Into Human Skin, In Vitro, Using the Franz Skin 0.025 transdermal delivery Cyclobenzaprine HCl.2% ActiveMax ActiveMax Finite Dose Model vehicle able to deliver Diclofenac Na...... 5% 0.020 0.10 multiple drugs beyond Gabapentin...... 6% 0.015

Using Humco’s SaltStable LS Advanced™, the study was the stratum corneum, 0.010 0.05 designed to evaluate the percutaneous absorption pharmacoki- Ibuprofen...... 3% simultaneously into (ug/cm2/hr) Flux 0.005 (ug/cm2/hr) Flux netics of pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine Ketamine HCl...... 10% and through the human Pentoxifylline...... 3% 0.000 0.00 HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin 2 4 8 12 24 32 48 0 2 4 8 12 24 32 48 skin after a single dose. SaltStable Time Time in a single formulation using Humco’s SaltStable LS Advanced™ The data indicates that LS Advanced.....qs 100% base. Absorption was measured in human epidermal cultures, in Humco’s SaltStable LS vitro, using the finite dose technique and Franz Diffusion Cells. Advanced™ delivered The eight drugs were selected due to their frequent use in com- pentoxifylline, ketamine pounding topical pain formulations along with compounding HCl, ibuprofen, cycloben- Cyclobenzaprine Flux VS Time Diclofenac Flux VS Time Gabapentin Flux VS Time 1.00 0.080 multiple actives in one formulation. 0.35 SaltStable LS zaprine HCl, diclofenac SaltStable LS 0.30 0.80 ActiveMax Na, baclofen, bupivacaine ActiveMax 0.060 The formula was tested on standardized sections with Humco’s 0.25 HCl, and gabapentin 0.60 0.20 SaltStable LS Advanced™ transdermal compounding base, for simultaneously (and 0.040 the percutaneous absorption of the formula over a 48-hour dose 0.15 0.40 intact) into and through 0.10 0.020 period. At pre-selected times after dose application, the dermal (ug/cm2/hr) Flux (ug/cm2/hr) Flux 0.20 (ug/cm2/hr) Flux human epidermal 0.05 receptor solution was removed in its entirety, replaced with 0.00 0.000 cultures, in vitro, from 0.00 fresh receptor solution, and an aliquot saved for subsequent 0 2 4 8 12 24 32 48 0 2 4 8 12 24 32 48 0 2 4 8 12 24 32 48 the test formulation Time Time Time analysis. High Performance Liquid Chromatography (HPLC) provided. The absorption analyzed the samples for pentoxifylline, ketamine HCl, ibuprofen, profiles indicate pent- cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl oxifylline, ketamine HCl, and gabapentin content. ibuprofen, diclofenac Na, and bupivacaine HCl Ibuprofen Flux VS Time Ketamine Flux VS Time Pentoxifylline Flux VS Time The in vitro human Epiderm skin model has proven to be a valu- 4.0 4.0 6.0 had a steady penetration SaltStable LS SaltStable LS able tool for the study of percutaneous absorption and the de- SaltStable LS occurring for 32 hours ActiveMax ActiveMax ActiveMax 3.0 3.0 termination of the pharmacokinetics of topically applied drugs. after dose application. 4.0

The model uses human epidermal skin mounted in specially And cyclobenzaprine HCl, 2.0 2.0 designed diffusion cells that allow the skin to be maintained at a baclofen and gabapentin 2.0 temperature and humidity that match typical in vitro conditions. 1.0 1.0

had a steady penetration (ug/cm2/hr) Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flux A finite dose of formulation is applied to the outer surface of the occurring for 48 hours 0.0 0.0 0.0 0 2 4 8 12 24 32 48 0 2 4 8 12 24 32 48 skin and drug absorption is measured by monitoring the rate of after dose application. 0 2 4 8 12 24 32 48 appearance in the receptor solution bathing the inner surface of Time Time Time the skin. Data defining total absorption, as well as rate of absorp- tion can be accurately determined in this model.

28 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 29 - - Transdermal 10% SANARE ADVANCED™ Study FLURBIPROFEN - - Transdermal Study Scar Therapy Base has been proven to transport multiple drugs into SANARE ADVANCED™ 5% LIDOCAINE and through human skin, performing significantly TRANSDERMAL STUDY Transdermal Study more effectively than our competitor’s base.

STUDY RESULTS Evaluation of the Percutaneous The data did indicate that Absorption of Flurbiprofen + Lidocaine Flurbiprofen Flux VS Time flurbiprofen penetrated into

45 and through human epidermal The study evaluated the percutaneous absorption pharma- Sanare Advanced 40 cultures, in vitro, from the test cokinetics of Humco’s Sanare 35 Competitor's Base formulations provided. The Advanced™ Scar Base. Absorption Sanare TESTED FORMULA 30 absorption profiles indicate was measured in human epidermal 25 a steady penetration for 48 cultures, in vitro, using the finite Flurbiprofen...... 10% 20 hours after dose application. Advanced™ dose technique and Franz Diffusion Lidocaine...... 5%

Flux (ug/cm2/hr) Flux 15 Sanare Advanced™ performed Cells. Sanare Advanced™...... qs 100% 10 significantly better than our 5 competitor's base at delivering out-performs The formula was tested on stan- 0 flurbiprofen through human skin. dardized sections with two different transdermal 0 2 4 8 12 24 32 48 Time Competitor’s compounding bases. At pre-selected times after dose The data also indicated that application, the dermal receptor solution was completely lidocaine penetrated into and removed and replaced with fresh receptor solution; and an through human epidermal Base aliquot was saved for subsequent analysis. Samples were cultures, in vitro, from the test analyzed for flurbiprofen and lidocaine content by High formulations provided. The Performance Liquid Chromatography (HPLC). by 23-28% Lidocaine Flux VS Time absorption profiles indicate a steady penetration for 48 hours The in vitro human Epiderm skin model is a proven tool, valuable 10 Sanare Advanced after dose application. Humco’s for the study of percutaneous absorption and determination of 8 Competitor's Base Sanare Advanced™ performed pharmacokinetics of topically applied drugs. The model uses significantly better than our human epidermal skin mounted in specially designed diffusion 6 competitor’s base at delivering cells that allow the skin to be maintained at a temperature and lidocaine through human skin. humidity that match typical in vitro conditions. A finite dose 4 of formulation is applied to the outer skin surface, and drug (ug/cm2/hr) Flux The total percent of applied dose absorption is measured by monitoring the rate of appearance in 2 that penetrated past the stratum the receptor solution bathing the inner surface of the skin. Data corneum with our competitor’s defining total absorption, as well as rate of absorption, can be 0 0 2 4 8 12 24 32 48 base is 23% less with flurbiprofen accurately determined in this model. Time and 28% less with lidocaine than Humco’s Sanare Advanced™. >View Full Study at www.Humco.com

30 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 31 Creams Gel Bases & - - - & Lotions SANARE ADVANCED™ LAVARE™ Ointments TOPICAL SILICONE BASE FOR SCAR THERAPY WATER-WASHABLE WOUND CARE BASE & OTHER CONDITIONS Item No. NDC No. Size Price Item No. NDC No. Size Price 0112-56 00395-0112-56 500 g $307.20 Lavare™ is a Polyethylene Glycol (PEG) based occlusive, water-soluble 7001-62 00395-7001-62 100 g $166.40 0112-59 00395-0112-59 2500 g $1372.80 gel specifically formulated for wound management by promoting a 7001-56 00395-7001-56 500 g $661.60 0112-31 00395-0112-31 5800 g $2825.00 Sanare Advanced™ is an elegant, topical anhydrous silicone gel moist environment allowing for optimal healing. Lavare™ contains 7001-59 00395-7001-59 2500 g $2870.40 designed for scar therapy treatment and management. It is uniquely organic Meadowsweet Extract potentially providing germicidal formulated with Carapa Guaianensis Seed Oil found in the Amazon anti-inflammatory and healing properties along with the ability to rainforest, an exceptional ingredient that promotes skin renewal, deliver APIs topically to sensitive wound sites. inflammation reduction, and healing. Added emollients and emulsifiers Common Actives allow for versatile compounding for scar and other skin conditions. Common Actives in Scar Care: LAVARE™ BENEFITS: in Wound Care: • Adherent base – occlusive Misoprostol – 0.0024% Pentoxifylline – 0.1 – 0.5% SANARE ADVANCED™ BENEFITS: Decreases collagen production, • Water-washable allowing for easy cleaning and Synthetic analogue of prostaglandin E1, attenuate the inflammatory increases activity of Collagenase • Provides barrier protection debridement in dermis, inhibits fibroblast process and promote collagen hyperactivity • Increased skin penetration • Maintains a moist wound site providing an optimal healing formation by inhibiting IL-1 and • Formulated for higher loads of polar salt APIs environment TNF, modulates inflammation and decreases wound healing time – 0.1% • Skin renewal and inflammation reduction • API Compatibility – hydrophilic and lipophilic actives and anti-inflammatory • Soy, gluten, and irritant free • Soy and gluten free Phenytoin – 5% Dimethyl Sulfone – 2% Stimulates collagen deposition, fibro- blast proliferation, Anti-inflammatory antagonism, and has antibacterial SANARE ADVANCED™ PROPERTIES LAVARE ™ PROPERTIES activity EGCg – 0.1 – 0.5% – Antioxidant Specific Gravity 1.12 g/mL pH 6.0 Lidocaine – 4% – Topical Caffeine – 0.1 – 1% Physical Format Viscous Gel Specific Gravity 1.12 g/cm³ Induces differentiation and proliferation in epidermal keratino- Solubility in Water Insoluble Physical Format Non-Flowable Gel cytes Metronidazole – 2% Color Opaque, Off-White Solubility in Water Complete Deodorizing effect of Metronidazole Collagenase – 350 u/g • New Scars • Old Scars • Surgical Scars Color White correlate with eradication of Reduces collagen production Typical Applications • Acne Scars • Keloids • Stretch Marks anaerobic • Scar Tissue Typical Applications • Wounds • Ulcers • Burns • Cuts • Abrasions • Dermatological Applications Hyaluronidase – 250 u/g Nifedipine – 2% Breaks down collagen Ca2+ that greatly improves tissue perfusion and Tranilast – 1 – 10% SAMPLE FORMULAS: SAMPLE FORMULAS: improves healing time Anti-collagen Dosage: Apply 2-6 grams topically to affected area 2-4 times daily for 10 to 14 weeks or as directed. Dosage: Apply up to 4 grams topically 3 times daily as directed, up to 12 grams per day. – 0.2% –

Keloids & Hypertrophic Post–Surgical Scars with Rosacea: No Odor/ No Pain: No Odor / Pain: Infected Wound: Mixing Tips Scars: Pain: Metronidazole 1% Misoprostol 0.0024% Misoprostol 0.0024% Gentamicin 0.1%/g • Recommended Wetting Agent: 0.1% Gabapentin 15% Niacinamide 4% Phenytoin 5% Phenytoin 5% 0.1%/g Tranilast 1% Lidocaine 3% Sanare Advanced qs 100% Fatty Acid (Isopropyl Lavare Gel qs 100% Lidocaine 4% Polymyxin 2,000 u/g Sanare Advanced qs 100% Prilocaine 3% Lavare Gel qs 100% Lavare Gel qs 100% Palmitate), Fatty Sanare Advanced qs 100% Odor / No Pain: Acne Scars: (Oleyl Alcohol), or Anhydrous Misoprostol 0.0024% Infected Wound: Wound Care: Post–Surgical Scars/ Age Spots & Wrinkles: Lipoic Acid 0.5% Phenytoin 5% Misoprostol 0.0024% Ketoprofen 2% Alcohol (Ethanol 200 Proof) New Scars: Hydroquinone 8% Tretinoin 0.1% Metronidazole 2% Phenytoin 5% Lidocaine 2% Mixing Tip Collagenase 350 u/g 1% Sanare Advanced qs 100% Lavare Gel qs 100% Gentamicin 0.2% Misoprostol 0.0024% • Recommended Wetting Agent: Maximum Amount 10% Hyaluronidase 250 u/g Kojic Acid 4% Lavare Gel qs 100% Phenytoin 2% Sanare Advanced qs 100% Tretinoin 0.05% Aloe Vera 0.2% Glycerin, Maximum Amount 10% Sanare Advanced qs 100% • Recommended to Reduce Stickiness: Lavare Gel qs 100% Cyclomethicone 5 - 10%

32 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 33 Gel Bases Gel Bases & & Ointments PLO20 FLOWABLE™ PLO20 NON-FLOWABLE™ Ointments PRE-MADE FLOWABLE PLO PRE-MADE PLO

Item No. NDC No. Size Price Item No. NDC No. Size Price 0135-01 00395-0135-01 1 lb $65.00 PLO20 Flowable™ is a robust, ready-to-use transdermal base that rep- PLO20 Non-Flowable™ and PLO20 Flowable™ are ready-to-use, absorp- 6008-01 00395-6008-01 1 lb $50.00 resents the next generation of pluronic lecithin organogel (PLO) bases. tion-enhanced transdermal vehicles that are elegant alternatives to PLO 6008-79 00395-6008-79 10 lb $365.00 This cosmetically elegant base has a lotion consistency that allows transdermal systems. They contain penetration enhancers to facilitate 6008-81 00395-6008-81 40 lb $1310.00 for incorporating high levels of APIs. It contains the same stability more efficacious active drug absorption, emollients for a better rub-in, properties as PLO20 Non-Flowable™, allowing for versatile compound- preservatives for increased mold resistance, along with emulsifiers ing. PLO20 Flowable™ provides enhanced chemical penetration that allowing for better cold-temperature stability. PLO20 Non-Flowable™ and HUMCO'S allows a deeper skin permeation than does PLO20 Non-Flowable™. PLO20 Flowable™ may be blended for viscosity optimization without SAMPLE FORMULA: PLO20 FLOWABLE™ This product is designed to accept the incorporation of high levels of wetting agents or milling to thin the formula, thus allowing for versatile lipophilic actives and moderate levels of hydrophilic actives. compounding. Anti-/Pain Management VS Cream: TRADITIONAL PLO Promethazine 5% & COMPETITOR'S BASE PLO20 FLOWABLE & PLO20 NON-FLOWABLE™ BENEFITS: • Enhanced penetration – more efficacious drug absorption Published Studies – Beyond-Use-Date (BUD) Humco's • API compatibility – high lipophilic & moderate hydrophilic ACTIVE INGREDIENT PLO20 NON-FLOWABLE™ PLO20 FLOWABLE™ PLO20 Flowable™...... 44% carrying capacity Diltiazem – 2% 90 Days – Competitor’s Base...... 39% • Adjustable viscosity – PLO20™ & PLO20 Flowable™ may be blended Gabapentin – 6% 90 Days – Traditional PLO...... 17% • Temperature & shelf stable

• Cosmetically elegant Haloperidol – 2% – 90 Days Cumulative % Permeation of • Validated API compatibility & penetration Ibuprofen – 10%– (Piroxicam) 60 Days – Methimazole through the • No wetting or milling – high levels of oil-soluble powders & moderate Ibuprofen – 20% – (Piroxicam) 90 Days 90 Days Stratum Corneum levels of water-soluble powders may be directly incorporated Ketoprofen – 10% – (Piroxicam) 90 Days – Methimazole – 5% – 90 Days PROPERTIES PLO20 NON-FLOWABLE™ PLO20 FLOWABLE™ Piroxicam – 1% – (Ibuprofen, Ketoprofen) 60 Days – pH 7.0 7.0 Piroxicam – 2% – (Ibuprofen, Ketoprofen) – 60 Days Specific Gravity 0.97 g/ml 0.97 g/ml Prednisolone– 5% 90 Days – Viscosity 300,000 cps 30,000 cps Prednisone – 5% 90 Days – Format Heavy Cream Light Cream/Lotion Prednisone – 10% – 90 Days Color Light Yellow Light Yellow Promethazine – 5% 90 Days – Transdermal Penetration + + + + + + + + + Hydrophilic – 10% Hydrophilic – 10% API Compatibility Lipophilic – 10% Lipophilic – 30% Total API Load – 10% Total API Load – 30% WHEN DO YOU NEED PLO20™ OR PLO20 FLOWABLE™?

Best Use Low Levels of Lipophilics High Levels of Lipophilics • When you want more efficacious active drug absorption. • Pain Management • Pain Management • When you want to incorporate high levels of lipophilic substances. Typical Applications • Sports Medicine • Sports Medicine • Diabetes & Wound Care • Immunotherapy • When you want a creamier base than a traditional PLO that is more • Veterinary Medicine • Veterinary Medicine cosmetically elegant and less sticky. • When you want a penetrating cream that can be shipoed in cold temperatures.

34 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 35 Gel Bases Bulk Compounding & UNIVERSAL DICLOFENAC SODIUM Drug Ointments WATER GEL™ 3% CREAM, USP NDC 0395 Substances WARNING: Harmful if swallowed. Causes CAS # Diclofenac Sodium 15307-79-6 serious eye irritation. Prevention: Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Wear eye/face VERSATILE TOPICAL GEL BASE TOPICAL BASE protection. Response: If swallowed: call a poison center/doctor/medical professional/ if you feel unwell. Rinse mouth. If in eyes. Rinse Item No. NDC No. Size Price Universal Water Gel™ is an oil and salt tolerant blend using hydro- Diclofenac Sodium 3% Cream, USP is a creamy emulsion cautiously with water for several minutes. 6017-01 00395-6017-01 1 lb $21.00 Diclofenac Sodium Cream 3%, USP Remove contact lenses. If present and easy to 6017-79 00395-6017-79 10 lb $165.00 phobic-inclusive cyclodextrins and electrolyte-tolerant polymers that provided in bulk form as a base for prescription compounding do. Continue rinsing. If eye irritation persists: FOR PRESCRIPTION COMPOUNDING ONLY greatly increases the water solubility and stability of incompatible that contains Diclofenac Sodium 3% in a cosmetically Get medical advice/attention. Disposal: Dispose of contents/container to an approved drugs. Ideal for formulas containing higher levels of oils, botanical elegant cream. Diclofenac 3% Cream, USP was designed disposal site. Do Not Use if Sealing Pins are ingredients, or poorly soluble actives. It provides improvements in specifically to hold additional API's for further compounding, Diclofenac Sodium, USP...... 3.0% Broken or Removed. Store at: Controlled Cream...... 97.0% Room Temperature (20°C – 25°C). solubility, increase in speed of dissolution, together with physical and including API's that a pharmacist may choose to aid in pain chemical stability. management. Conveniently packaged with the pharmacist in mind, Diclofenac 3% Cream, USP is available in bulk packaging to save time and money and increase efficiency in place of Not in Dosage Unit Form NOT IN DOSAGE UNIT FORM Manufactured by: UNIVERSAL WATER GEL™ BENEFITS: compounding from unit of use package sizes. Humco Holding Group • API compatibility – hydrophilic & lipophilic Texarkana, TX 7550 1 • Excellent electrolyte tolerance Item No. NDC No. Size Price Made in USA 6120-59 00395-6120-59 2500 g Call for • enhancement Pricing • Improves active stabilization & compatibility DICLOFENAC SODIUM 3% CREAM, USP BENEFITS: rectangle - Pantone 3135C • Highly stable across a broad pH range • Penetration Ability - Contains penetration enhancers to • Masks the odor of unpleasant actives facilitate API absorption • Cosmetically elegant • Time saving - Packaged in bulk to save time compounding • Applies Easily - No sticky residue

UNIVERSAL WATER GEL™ PROPERTIES pH 7.0

Specific Gravity 0.95 g/cm³ DICLOFENAC SODIUM 3% CREAM, USP PROPERTIES Viscosity 750,000 cps pH 6.0 - 8.0 Physical Format Gel Physical Format Viscous vanishing topical cream Color Translucent Color Brilliant White Transdermal Penetration + Typical Applications Compounding Base Hydrophilic & Lipophilic API Compatibility Total API Load - less than 10% • Dermatology Typical Applications • Pain Management • Diabetes & Wound Care

36 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855)-925-4736 • HUMCO 37 Bulk Bulk Compounding LIDOCAINE 5% LIDOCAINE AND Compounding Drug Drug Substances Substances NDC 0395 OINTMENT,USPWARNING: Harmful if swallowed. Causes PRILOCAINE CREAM, USP CAS # Lidocaine serious eye irritation. Prevention: Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Wear eye/face TOPICALprotection. Response: If BASEswallowed: call a TOPICAL BASE poison center/doctor/medical professional/ if you feel unwell. Rinse mouth. If in eyes. Rinse Lidocaine Ointment 5%, USP Lidocainecautiously with water5% forOintment, several minutes. USP is a water washable ointment Lidocaine and Prilocaine Cream, USP is provided in bulk providedRemove contact in lenses. bulk If form present andas easy a baseto for prescription com- form as a base for prescription compounding that contains do. Continue rinsing. If eye irritation persists: FOR PRESCRIPTION COMPOUNDING ONLY poundingGet medical advice/attention. that contains Disposal: Lidocaine 5% in a cosmetically Lidocaine 2.5% and Prilocaine 2.5% in a cosmetically elegant elegantDispose of contents/containercream. Humco’s to an approved Lidocaine 5% Ointment, USP is a cream. Lidocaine and Prilocaine Cream, USP was designed disposal site. Do Not Use if Sealing Pins are Lidocaine, USP...... 5.0% waterBroken orsoluble Removed. Storebase at: Controlled containing polyethylene glycol (PEG) specifically to hold additional APIs for further compounding Ointment...... 95.0% 400,Room polyethylene Temperature (20°C – 25°C). glycol (PEG) 330, propylene glycol, zinc including APIs that a pharmacist may choose to aid in pain acetate, and botanical extracts. Lidocaine 5% Ointment, management. Conveniently packaged with the pharmacist USP was designed specifically to hold additional APIs for in mind, Lidocaine and Prilocaine Cream, USP is available in NOTNot in D osageIN DOSAGE Unit Form UNIT FORM further compounding including APIs that a pharmacist may bulk packaging to save time and money and increase effi- NOT IN DOSAGE UNIT FORM chooseManufactu tored aid by: in pain management. Conveniently packaged ciency in place of compounding from unit of use package Humco Holding Group Item No. NDC No. Size Price withTexa rthekana, pharmacist TX 75501 in mind, Lidocaine 5% Ointment, USP sizes. Item No. NDC No. Size Price 6130-59 00395-6130-59 2500 g Call for 6110-31 00395-6110-31 5800 g Call for Pricing isMa availablede in USA in bulk packaging to save time and money and 6110-58 00395-6110-58 18000 g Pricing increase efficiency in place of compounding from unit of use package sizes. LIDOCAINE AND PRILOCAINE CREAM, USP rectangle - Pantone 3135C BENEFITS: • Penetration Ability - Contains penetration enhancers to LIDOCAINE 5% OINTMENT, USP BENEFITS: facilitate API absorption • Adherent base - occlusive • Applies Easily - No sticky residue • Time saving - packaged in bulk to save time compounding • Drug Compatibility - Can hold both hydrophilic & lipophilic • Water washable and soluble APIs • Applies Easily - No sticky residue • Time Saving - Packaged in bulk to save time compounding Common Actives Common Actives for Compounding with for Compounding: Lidocaine and Prilocaine Cream, USP: Diclofenac Sodium –2 - 6% LIDOCAINE 5% OINTMENT, USP PROPERTIES LIDOCAINE AND PRILOCAINE CREAM, USP PROPERTIES Amitriptyline – 2% Baclofen – 2% pH 6.0 - 8.0 pH 8.7 - 9.7 Diclofenac Sodium – 2-6% Ketamine HCL – 5 - 10% Physical Format Viscous, water-soluble ointment Viscosity 800,000 - 1,600,000 cps Gabapentin – 6% Color Translucent White Physical Format Viscous Cream Gabapentin – 5 - 10% Typical Applications Compounding Base Color Opaque, Off-White – 0.2% - 0.375%

Typical Applications Compounding Base – 1.25%

Cyclobenzaprine HCl – 2%

Baclofen – 2%

Ketamine – 5 - 20%

38 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 39 Pre-Mixed Oral Excipient EMULSION Vehicles Bases CONCENTRATE™ BUFFER CREAM™ COMPOUNDING ENHANCER SWEETENED BUFFERING AGENT FOR ORAL SUSPENSIONS Item No. NDC No. Size Price Item No. NDC No. Size Price 6016-94 00395-6016-94 4 oz $35.00 Emulsion Concentrate™ is a pH and salt-tolerant emulsifier/hydrocolloid 3926-01 00395-3926-01 1 lb $28.60 6016-98 00395-6016-98 8 oz $57.00 blend that greatly increases emulsification, stability, and thickness of Buffer Cream™ is a sweetened buffering agent in powder form 6016-28 00395-6016-28 1 gal $800.00 broken emulsions, and separated and thin formulations. It quickly forms developed to provide an alkaline buffer for compounding oral emulsions that are fresh, elegant, fast-absorbing, and non-greasy. pump inhibitor (PPI) suspensions. It provides immediate release and rapid absorption of PPI actives and is free of milk and protein. Buffer EMULSION CONCENTRATE™ BENEFITS: Cream is highly palatable with added sweeteners for either flavored • Ready-to-use polymer in fluid form or unflavored alkaline solutions to help overcome patient compliance • API compatibility – virtually all APIs difficulties. • Elegant sensory profile WHEN DO YOU NEED • Low & high temperature resistant (-5º C – 80º C) HUMCO'S BUFFER • Ingredient compatibility BUFFER CREAM™ BENEFITS: CREAM? • Broad range of applications • Alkaline buffer • Immediate release & rapid absorption • When you want a sweet- EMULSION CONCENTRATE™ PROPERTIES • Validated long-term stability ened buffer product for pH 4.5 - 6.5 • Masks unpleasant preparing oral suspensions • API compatibility – all PPIs Viscosity 75,000 cps • When you want an alkaline • Flavor versatility buffer Physical Format Viscous Gel • When you want palatability BUFFER CREAM™ PROPERTIES Color Opaque • When you want a product • Emulsify all types of oily phases Physical Format White Powder with Translucent Sheen that contains no milk or • Stabilize mineral additives Suspension Stability Up to 35 days protein Intended Use • Thicken in adverse conditions – very acidic or very alkaline, oxidizing API Compatibility All PPI’s (Proton Pump Inhibitors) • Develop fresh formulas that melt on contact with the skin Flavor Versatility Any Flavor API Compatibility Virtually all APIs pH Compatibility 2.0 - 12.0 Long-Term Stability Salt Tolerance Salt Forms – 35% ACTIVE INGREDIENT STABILITY Solvent Compatibility Polar & Non-Polar Lansoprazole Stable - 21 Days at 25° C Temperature Stability Low & High Temperatures Omeprazole Stable - 35 Days at 25° C Ethanol, Propylene Glycol, Butylene Glycol, Glycerin, Applications Hexylene Glycol, Methylpropane Diol, , Vegetable Pantoprazole Stable - 7 Days at 25° C Oils, Silicone Oils, Mineral Oils, Esters & Sun Filters

SAMPLE FORMULA:

DIFFERENT VISCOSITIES ARE ACHIEVED BY Instructions: VARYING THE AMOUNT OF EMULSION 1. Add omeprazole to 90 mL - 8.4% sodium bicarbonate, refrigerate for at least 1 hour and mix until dissolved. CONCENTRATE: 2. Add ompreazole solution to Humco Buffer Cream to qs volume - 120 mL and shake well. 3. Add flavor is desired. 3% FOR LOTIONS Omeprazole 10 mg/mL Suspension: 5% FOR CREAMS Humco Buffer Cream 54 g Omeprazole 1.2 g 8.4% Sodium Bicarbonate qs 120 mL

40 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 41 Oral Oral Vehicles Vehicles MOUTHWASH-GP™ MOUTHWASH-OM™ GENERAL PURPOSE MOUTHWASH BASE MOUTHWASH BASE FOR ORAL MUCOSITIS

Item No. NDC No. Size Price Item No. NDC No. Size Price 6030-98 00395-6030-98 8 oz $9.74 Mouthwash-GP™ is a mouthwash base designed to simplify and Mouthwash-OM™ is a mouthwash base designed to aid symptoms of 6040-98 00395-6040-98 8 oz $9.74 standardize the extemporaneous compounding of formulations for Oral Mucositis associated with cancer therapy and certain dental condi- delivery to the oral cavity. The pH of Mouthwash-GP™ is buffered to tions. In addition to being alcohol-free, Mouthwash-OM™ contains match the natural pH of saliva. The viscous nature of the Mouth- excipients that are compatible with water-soluble drugs for the treatment wash-GP product allows the pharmacist to dissolve and/or suspend of oral pain, mouth sores, and oral . most of the common actives that are prescribed in “Magic Mouth- wash”. Mouthwash-GP™ is designed to dissolve or suspend a high MOUTHWASH-OM™ BENEFITS: SAMPLE FORMULAS: amount of active ingredients - maintaining its viscosity when actives Pain Relief Gargle: • Soothing oral moisturizer Lidocaine HCl 1.5% are added - such that the oral cavity is coated with medication. The • Alcohol-free - no burn Sucralfate 5% Diphenhydramine HCl 0.5% Flavoring Mouthwash-GP™ packaging container has added head space which • Container head space for mixing Mouthwash-OM qs 100% Suggestions? allows for mixing of actives by shaking the container. • Dye and flavor free Xerostomia Rinse: • Contains botanical extracts Pilocarpine HCl 1% • For formulations containing MOUTHWASH-GP™ BENEFITS: • Compatible with flavors/dyes that are available for -masking of Mouthwash-OM qs 100% Diphenhydramine HCL, use: • Oral moisturizer bitter or unpleasant tasting actives Banana, Apple, Bubble Gum • Coats the mouth • Container head space for mixing • For formulations containing • Dye and flavor free /Bio- • Easily tailored with flavors and colors to improve palatability Suspension, use: • Compatible with flavors/dyes that are available for taste-masking of Sour Apple, Watermelon, bitter or unpleasant tasting actives MOUTHWASH-AF™ Cherry MOUTHWASH-GP™ PROPERTIES ALCOHOL-FREE MOUTHWASH BASE FOR • For formulations containing pH 5.0 - 7.0 , use: HYDROPHOBIC ACTIVES Bubble Gum, Grape, Apple Viscosity 1,500 - 4,000 cps Mouthwash-AF™ is a mouthwash base designed to provide Item No. NDC No. Size Price Physical Format Viscous Liquid Solution 6050-98 00395-6050-98 8 oz $9.74 solubility of hydrophobic active ingredients while being compatible with • For formulations containing Color Clear Liquid the . In addition to being alcohol-free, Mouthwash-AF™ , use: Grape, Alcohol Content 10.6% w/w contains excipients that dissolve and coat the mouth with drugs for the Watermelon, Strawberry • Chemotherapy mouth ulcers treatment of oral pain, mouth sores, and oral infections. Intended Use • Bacterial/viral oral infections SAMPLE FORMULAS: • Gingival irritation caused by braces MOUTHWASH-AF™ BENEFITS: • Throat/esophageal sores Esophageal Suspension: • Solubilizers for hydrophobic actives 0.1% API Compatibility Compatible with most “Magic Mouthwash” actives Mouthwash-GP or AF qs 100% • Alcohol-free - no burn Delivery Method Can be expectorated or swallowed • Container head space for mixing Anti-Infective Mouthwash: • Dye and flavor free Nystatin 1% Tetracycline HCl 2% SAMPLE FORMULAS: • Compatible with hydrophobic and hydrophilic actives Acyclovir 5% Deoxy D- 2% BLM Magic Mouthwash: Mary’s Magic Mouthwash: Anti-Viral Mouth Rinse: • Compatible with flavors/dyes that are available for taste-masking of Mouthwash-AF qs 100% Diphenhydramine HCl 0.1% Diphenhydramine HCl 0.25% Acyclovir 5% bitter or unpleasant tasting actives Lidocaine HCl 1% Hydrocortisone 0.05% Mouthwash-AF 45% Aluminum Hydroxide/ Nystatin 0.5% Lidocaine HCl 1% Magnesium Hydroxide/ Tetracycline HCl 0.65% Deoxy D-Glucose 2% Simethicone Suspension 37.5% Mouthwash-GP qs 100% Mouthwash-GP qs 100% Mouthwash-GP qs 100%

42 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 43 Oral Oral Vehicles FLAVOR SWEET™ FLAVOR PLUS™ Vehicles SYRUP VEHICLE ORAL SUSPENDING VEHICLE Flavor Sweet™ is a cherry-flavored syrup vehicle formulated to simplify Flavor Plus™ is a unique flavor-free, aqueous based suspending vehicle the preparation of oral extemporaneous delivery systems. It may used to simplify the process of compounding oral non-soluble suspen- Item No. NDC No. Size Price Item No. NDC No. Size Price 0090-16 00395-0090-16 16 oz $9.55 be used alone or in conjunction with other agents to give flavor and sions. It is buffered to an acidic pH providing 0091-16 00395-0091-16 16 oz $9.55 0090-28 00395-0090-28 1 gal $62.00 sweetness while increasing the suspension’s physical stability. Flavor a uniform, consistent and stable vehicle. 0091-28 00395-0091-28 1 gal $62.00 Sweet™ contains suitable preservatives and is buffered to a slightly • Flavor-free, white liquid suspension acidic pH to provide a dependable and consistent vehicle. • pH 3.5 – pH 4.0 • Pink colored, cherry flavored syrup • Recommended use – hydrophilic, acid-stable & hydrophobic actives • pH 4.5 – pH 5.0 • Ideal for diabetic preparations • Recommended use – hydrophilic, acid-stable & hydrophobic actives FLAVOR BLEND™ FLAVOR SWEET-SF™ ALL-IN-ONE SYRUP/SUSPENDING VEHICLE SUGAR-FREE SYRUP VEHICLE Flavor Blend™ is a uniquely formulated flavored oral suspending vehicle designed to simplify the extemporaneous compounding process of Flavor Sweet SF™ is a sugar-free and alcohol-free cherry flavored oral suspensions. It combines the flavoring agents of Flavor Sweet™ Item No. NDC No. Size Price syrup. It may be used alone or in conjunction with other agents to give and the suspending agents of Flavor Plus™, along with preservatives Item No. NDC No. Size Price 0094-16 00395-0094-16 16 oz $9.55 0089-16 00395-0089-16 16 oz $9.55 0094-28 00395-0094-28 1 gal $62.00 flavor and sweetness while increasing the suspension’s physical stabil- and an anti-foam agent to provide an easy preparation of smooth, 0089-28 00395-0089-28 1 gal $62.00 ity. Flavor Sweet SF™ contains suitable preservatives and is buffered to elegant oral suspensions. a slightly acidic pH to provide a dependable and consistent vehicle. • Easy to use • Pink colored, cherry flavored, sugar-free syrup • Light pink liquid blend with a cherry flavor • pH 4.5 – pH 5.0 • pH 4.5 – pH 5.0 • Recommended use – hydrophilic, acid-stable & hydrophobic actives • Recommended use – hydrophilic, acid-stable & hydrophobic actives • Ideal for diabetic preparations • Incorporate virtually all medicated powders or crushed tablets • Ideal for pediatric & geriatric preparations VERSA FREE™ VERSA PLUS™ DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SYRUP VEHICLE SUSPENSION VEHICLE

Versa Free ™ is a dye-free, flavor-free, paraben-free, sugar-free, Versa Plus ™ is a dye-free, flavor-free, paraben-free, sugar-free, Item No. NDC No. Size Price 0126-16 00395-0126-16 16 oz $10.47 Item No. NDC No. Size Price gluten-free and saccharin-free syrup vehicle resulting in fewer patient gluten-free and saccharin-free suspension vehicle resulting in fewer 0126-28 00395-0126-28 1 gal $75.00 0125-16 00395-0125-16 16 oz $10.47 allergic reactions. Virtually no aftertaste. patient allergic reactions. Virtually no aftertaste. 0125-28 00395-0125-28 1 gal $75.00 • Flavor-free clear liquid syrup • Flavor-free white liquid suspension • pH 4.5 – pH 5.0 • pH 3.5 – pH 4.0 • Natural ingredients & natural preservatives • Natural ingredients & natural preservatives • Recommended use – hydrophilic, acid-stable & hydrophobic actives • Recommended use – hydrophilic, acid-stable & hydrophobic actives • Ideal for diabetic & allergy-sensitive patients • Ideal for diabetic & allergy-sensitive patients • Soy & gluten-free • Soy & gluten-free

44 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 45 Oral ADDITIONAL ADDITIONAL Miscellaneous Vehicles ORAL VEHICLES CMPDG INGREDIENTS Ingredients

Almond Oil Sweet, NF Item No. Size Price Product Ingredients Ordering Information 1907-91 1 oz $5.69 1907-16 16 oz $40.43 Cherry Syrup™ 82% w/v, purified water, Item No. Size Price artificial cherry flavors, citric acid, 2662-16 16 oz $9.30 Arnica Tincture Item No. Size Price Recommended Use: FDC Red #40, sodium benzoate as 2662-28 1 gal $56.00 0115-94 4 oz $34.48 Ionic & Hydrophilic Actives a preservative, inert ingredients and natural preservatives Item No. Size Price Barium Sulfate Powder USP 0200-01 1 lb $53.45

Benzoin Compound Tincture USP Item No. Size Price Raspberry Syrup Sucrose 82% w/v, purified water, Item No. Size Price 0243-92 2 oz $6.23 artificial raspberry flavors, citric acid, 2664-16 16 oz $9.83 0243-16 16 oz $42.34 Recommended Use: FDC Red #40, FDC Blue #1, sodium Ionic & Hydrophilic Actives benzoate as a preservative, inert Item No. Size Price ingredients and natural preservatives. Bicarbonate Powder 0261-01 1 lb $136.83

Item No. Size Price Coal Tar Topical Solution USP 0617-16 16 oz $24.18 Simple Syrup Sucrose 85% w/v, citric acid, purified Item No. Size Price water, methyl paraben as a preservative 2662-16 16 oz $9.30 Item No. Size Price Recommended Use: along with natural preservatives. 2662-28 1 gal $56.00 Glycerin USP 1031-96 6 oz $5.82 Ionic & Hydrophilic Actives 1031-28 1 gal $102.16 1031-75 5 gal $150.07 Natural ingredients and preservatives— Item No. Size Price Sorbitol Solution Iodine Tincture, Mild 2% USP Item No. Size Price 70%, USP 70% solution of sorbitol and purified 3913-16 16 oz $4.96 1213-91 1 oz $2.45 water. 1213-16 16 oz $23.17 Recommended Use: Ionic & Hydrophilic Actives, Diabetic Additives Item No. Size Price Mineral Oil Light 1673-28 1 gal $101.68 Sucrose 83% w/v, purified water, Item No. Size Price Syrpalta (red) Item No. Size Price glycerin, artificial flavors, 0.2% alcohol, 3920-16 16 oz $12.04 Recommended Use: 0.1% sodium benzoate, 0.001% benzal- 1997-94 4 oz $7.70 Ionic & Hydrophilic Actives konium chloride as a preservative and 1997-28 1 gal $46.55 inert ingredients. Item No. Size Price Peruvian Balsam 2255-94 4 oz $34.56 Syrpalta (without color) Sucrose 83% w/v, purified water, Item No. Size Price artificial flavors, 0.2% alcohol, 0.1% 3927-16 16 oz $12.64 Polyethylene Glycol 300 Item No. Size Price Recommended Use: sodium benzoate, 0.001% benzalko- 2335-75 5 gal $238.67 Ionic & Hydrophilic Actives nium chloride as a preservative, inert ingredients and natural preservatives. Item No. Size Price Propylene Glycol 2327-28 1 gal $36.48

Item No. Size Price Powder USP 2625-94 4 oz $12.31 2625-01 1 lb $39.03 * To purchase this item you must have Strong Iodine Solution (Lugol's) * Item No. Size Price a DEA license on 2775-16 16 oz $56.20 file

46 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 47 HUMCO GLOBAL HEADQUARTERS 201 West 5th Street Floor 12 +1 (855) 925-4736 Austin, TX 78701 www.Humco.com