Supplementary Table 5. Proteins Predicted to Use a Transmembrane Helix for Membrane Targeting

Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA0005 probable acyltransferase PA0010 tag DNA-3-methyladenine glycosidase I PA0013 conserved hypothetical protein PA0029 probable sulfate transporter PA0043 hypothetical protein PA0055 hypothetical protein PA0064 hypothetical protein PA0072 hypothetical protein PA0074 ppkA serine/threonine protein kinase PpkA PA0077 hypothetical protein PA0078 hypothetical protein PA0093 hypothetical protein PA0103 probable sulfate transporter PA0106 coxA cytochrome c oxidase, subunit I PA0107 conserved hypothetical protein PA0108 coIII cytochrome c oxidase, subunit III PA0109 hypothetical protein PA0110 hypothetical protein PA0111 hypothetical protein PA0113 probable cytochrome c oxidase assembly factor PA0119 probable dicarboxylate transporter PA0129 gabP gamma-aminobutyrate permease PA0137 probable permease of ABC transporter PA0138 probable permease of ABC transporter PA0150 probable transmembrane sensor PA0158 probable RND efflux transporter PA0166 probable transporter PA0172 hypothetical protein PA0180 probable chemotaxis transducer PA0185 probable permease of ABC transporter PA0188 hypothetical protein PA0195 pntA still frameshift pyridine nucleotide transhydrogenase alpha subunit PA0196 pntB pyridine nucleotide transhydrogenase, beta subunit PA0197 hypothetical protein PA0198 exbB1 transport protein ExbB PA0199 exbD1 transport protein ExbD PA0204 probable permease of ABC transporter PA0205 probable permease of ABC transporter PA0215 probable transporter PA0216 probable transporter PA0220 probable amino acid permease PA0229 pcaT dicarboxylic acid transporter PcaT PA0235 pcaK 4-hydroxybenzoate transporter PcaK PA0239 hypothetical protein PA0241 probable MFS transporter PA0246 probable MFS transporter PA0255 conserved hypothetical protein PA0276 hypothetical protein PA0278 hypothetical protein PA0281 cysW sulfate transport protein CysW Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA0282 cysT sulfate transport protein CysT PA0285 conserved hypothetical protein PA0286 probable fatty acid desaturase PA0287 probable sodium:solute symporter PA0303 spuG polyamine transport protein PotH PA0304 spuH polyamine transport protein PotI PA0313 probable permease of ABC transporter PA0319 hypothetical protein PA0322 probable transporter PA0324 probable permease of ABC transporter PA0325 probable permease of ABC transporter PA0332 hypothetical protein PA0333 hypothetical protein PA0334 probable MFS transporter PA0340 conserved hypothetical protein PA0341 lgt prolipoprotein diacylglyceryl transferase PA0345 hypothetical protein PA0352 probable transporter PA0375 ftsX cell division protein FtsX PA0377 hypothetical protein PA0378 probable transglycosylase PA0385 hypothetical protein PA0392 conserved hypothetical protein PA0397 probable cation efflux system protein PA0398 hypothetical protein PA0406 hypothetical protein PA0411 pilJ twitching motility protein PilJ PA0417 probable chemotaxis protein PA0422 conserved hypothetical protein PA0426 mexB RND multidrug efflux transporter MexB PA0433 hypothetical protein PA0435 hypothetical protein PA0438 codB cytosine permease PA0443 probable transporter PA0450 probable phosphate transporter PA0452 probable stomatin-like protein PA0454 conserved hypothetical protein PA0458 probable MFS transporter PA0461 conserved hypothetical protein PA0464 creC two-component sensor CreC PA0465 creD inner membrane protein CreD PA0466 hypothetical protein PA0471 probable transmembrane sensor PA0476 probable permease PA0485 conserved hypothetical protein PA0490 hypothetical protein PA0495 hypothetical protein PA0522 hypothetical protein PA0523 norC nitric-oxide reductase subunit C PA0524 norB nitric-oxide reductase subunit B Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA0526 hypothetical protein PA0538 dsbB disulfide bond formation protein PA0539 hypothetical protein PA0540 hypothetical protein PA0543 hypothetical protein PA0548 tktA transketolase PA0559 conserved hypothetical protein PA0561 hypothetical protein PA0563 conserved hypothetical protein PA0566 hypothetical protein PA0567 conserved hypothetical protein PA0573 hypothetical protein PA0598 hypothetical protein PA0605 probable permease of ABC transporter PA0606 probable permease of ABC transporter PA0614 hypothetical protein PA0616 hypothetical protein PA0640 probable bacteriophage protein PA0659 hypothetical protein PA0661 conserved hypothetical protein PA0663 hypothetical protein PA0676 probable transmembrane sensor PA0683 probable type II secretion system protein PA0684 probable type II secretion system protein PA0687 probable type II secretion system protein PA0694 exbD2 transport protein ExbD PA0695 hypothetical protein PA0702 hypothetical protein PA0703 probable MFS transporter PA0722 hypothetical protein of bacteriophage Pf1 PA0725 hypothetical protein of bacteriophage Pf1 PA0726 hypothetical protein of bacteriophage Pf1 PA0736 hypothetical protein PA0738 conserved hypothetical protein PA0742 hypothetical protein PA0751 conserved hypothetical protein PA0752 conserved hypothetical protein PA0763 mucA anti-sigma factor MucA PA0765 mucC positive regulator for alginate biosynthesis MucC PA0768 lepB signal peptidase I PA0783 putP sodium/proline symporter PutP PA0786 probable transporter PA0788 hypothetical protein PA0789 probable amino acid permease PA0790 hypothetical protein PA0800 hypothetical protein PA0802 hypothetical protein PA0807 conserved hypothetical protein PA0809 probable transporter PA0811 probable MFS transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA0825 hypothetical protein PA0834 conserved hypothetical protein PA0846 probable sulfate uptake protein PA0847 hypothetical protein PA0860 probable ATP-binding/permease fusion ABC transporter PA0861 hypothetical protein PA0866 aroP2 aromatic amino acid transport protein AroP2 PA0875 conserved hypothetical protein PA0885 probable C4-dicarboxylate transporter PA0886 probable C4-dicarboxylate transporter PA0889 aotQ arginine/ornithine transport protein AotQ PA0890 aotM arginine/ornithine transport protein AotM PA0908 hypothetical protein PA0909 hypothetical protein PA0913 mgtE probable Mg transporter MgtE PA0917 kup potassium uptake protein Kup PA0918 cytochrome b561 PA0920 hypothetical protein PA0921 hypothetical protein PA0924 hypothetical protein PA0930 two-component sensor PA0936 lpx2 lipopolysaccharide biosynthetic protein Lpx02 PA0938 hypothetical protein PA0948 hypothetical protein PA0951 probable ribonuclease PA0969 tolQ TolQ protein PA0970 tolR TolR protein PA0971 tolA TolA protein PA0980 hypothetical protein PA0984 colicin immunity protein PA0985 pyocin S5 PA0996 pqsA probable coenzyme A ligase PA1007 conserved hypothetical protein PA1037 conserved hypothetical protein PA1042 conserved hypothetical protein PA1044 hypothetical protein PA1045 hypothetical protein PA1051 probable transporter PA1054 probable NADH dehydrogenase PA1055 conserved hypothetical protein PA1056 probable NADH dehydrogenase PA1057 conserved hypothetical protein PA1058 conserved hypothetical protein PA1059 conserved hypothetical protein PA1068 probable heat shock protein (hsp90 family) PA1072 braE branched-chain amino acid transport protein BraE PA1073 braD branched-chain amino acid transport protein BraD PA1101 fliF flagellar M-ring protein PA1107 conserved hypothetical protein PA1113 probable ATP-binding/permease fusion ABC transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA1118 hypothetical protein PA1120 conserved hypothetical protein PA1126 hypothetical protein PA1131 probable MFS transporter PA1144 probable MFS transporter PA1147 probable amino acid permease PA1155 nrdB ribonucleoside reductase, small chain PA1158 probable two-component sensor PA1164 conserved hypothetical protein PA1170 conserved hypothetical protein PA1172 napC cytochrome c-type protein NapC PA1177 napE periplasmic nitrate reductase protein NapE PA1181 conserved hypothetical protein PA1183 dctA C4-dicarboxylate transport protein PA1190 conserved hypothetical protein PA1194 probable amino acid permease PA1203 hypothetical protein PA1207 kefB glutathione-regulated potassium-efflux system protein KefB PA1209 hypothetical protein PA1212 probable MFS transporter PA1213 hypothetical protein PA1230 hypothetical protein PA1232 hypothetical protein PA1236 probable MFS transporter PA1237 probable multidrug resistance efflux pump PA1246 aprD alkaline protease secretion protein AprD PA1247 aprE alkaline protease secretion protein AprE PA1251 probable chemotaxis transducer PA1257 probable permease of ABC transporter PA1258 probable permease of ABC transporter PA1262 probable MFS transporter PA1265 hypothetical protein PA1270 hypothetical protein PA1275 cobD cobalamin biosynthetic protein CobD PA1281 cobV cobalamin (5'-phosphate) synthase PA1282 probable MFS transporter PA1291 hypothetical protein PA1297 probable metal transporter PA1301 probable transmembrane sensor PA1305 hypothetical protein PA1308 hypothetical protein PA1313 probable MFS transporter PA1316 probable MFS transporter PA1317 cyoA cytochrome o ubiquinol oxidase subunit II PA1318 cyoB cytochrome o ubiquinol oxidase subunit I PA1319 cyoC cytochrome o ubiquinol oxidase subunit III PA1320 cyoD cytochrome o ubiquinol oxidase subunit IV PA1321 cyoE cytochrome o ubiquinol oxidase protein CyoE PA1323 hypothetical protein PA1331 conserved hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA1336 probable two-component sensor PA1340 probable permease of ABC transporter PA1341 probable permease of ABC transporter PA1344 probable short-chain dehydrogenase PA1348 hypothetical protein PA1361 probable transporter PA1364 probable transmembrane sensor PA1393 cysC adenosine 5'-phosphosulfate (APS) kinase PA1396 probable two-component sensor PA1411 hypothetical protein PA1412 hypothetical protein PA1418 probable sodium:solute symport protein PA1419 probable transporter PA1429 probable cation-transporting P-type ATPase PA1435 probable RND efflux membrane fusion protein precursor PA1436 probable RND efflux transporter PA1438 probable two-component sensor PA1439 conserved hypothetical protein PA1442 conserved hypothetical protein PA1447 fliQ flagellar biosynthetic protein FliQ PA1448 fliR flagellar biosynthetic protein FliR PA1449 flhB flagellar biosynthetic protein FlhB PA1452 flhA flagellar biosynthesis protein FlhA PA1460 probable chemotaxis transmembrane proton channel PA1461 probable chemotaxis protein PA1476 ccmB heme exporter protein CcmB PA1477 ccmC heme exporter protein CcmC PA1478 hypothetical protein PA1480 ccmF cytochrome C-type biogenesis protein CcmF PA1485 probable amino acid permease PA1491 probable transporter PA1496 probable potassium channel PA1497 probable transporter PA1507 probable transporter PA1513 hypothetical protein PA1519 probable transporter PA1525 alkB2 alkane-1-monooxygenase 2 PA1528 zipA cell division protein ZipA PA1540 conserved hypothetical protein PA1541 probable drug efflux transporter PA1542 hypothetical protein PA1547 hypothetical protein PA1548 conserved hypothetical protein PA1549 probable cation-transporting P-type ATPase PA1550 hypothetical protein PA1551 probable ferredoxin PA1552 probable cytochrome c PA1553 probable cytochrome c oxidase subunit PA1554 probable cytochrome oxidase subunit (cbb3-type) PA1555 probable cytochrome c Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA1556 probable cytochrome c oxidase subunit PA1557 probable cytochrome oxidase subunit (cbb3-type) PA1559 hypothetical protein PA1561 aer aerotaxis receptor Aer PA1569 probable MFS transporter PA1580 gltA citrate synthase PA1581 sdhC succinate dehydrogenase (C subunit) PA1582 sdhD succinate dehydrogenase (D subunit) PA1590 braB branched chain amino acid transporter PA1591 hypothetical protein PA1595 hypothetical protein PA1598 conserved hypothetical protein PA1604 hypothetical protein PA1608 probable chemotaxis transducer PA1611 probable sensor/response regulator hybrid PA1615 probable lipase PA1620 hypothetical protein PA1625 conserved hypothetical protein PA1626 probable MFS transporter PA1628 probable 3-hydroxyacyl-CoA dehydrogenase PA1632 kdpF KdpF protein PA1633 kdpA potassium-transporting ATPase, A chain PA1634 kdpB potassium-transporting ATPase, B chain PA1636 kdpD two-component sensor KdpD PA1646 probable chemotaxis transducer PA1647 probable sulfate transporter PA1650 probable transporter PA1651 probable transporter PA1652 hypothetical protein PA1668 hypothetical protein PA1676 hypothetical protein PA1679 hypothetical protein PA1682 probable MFS metabolite transporter PA1689 conserved hypothetical protein PA1690 pscU translocation protein in type III secretion PA1691 pscT translocation protein in type III secretion PA1692 probable translocation protein in type III secretion PA1693 pscR translocation protein in type III secretion PA1703 pcrD type III secretory apparatus protein PcrD PA1708 popB translocator protein PopB PA1709 popD translocator protein PopD PA1717 pscD type III export protein PscD PA1727 conserved hypothetical protein PA1735 hypothetical protein PA1752 hypothetical protein PA1773 conserved hypothetical protein PA1775 conserved hypothetical protein PA1782 probable serine/threonine-protein kinase PA1783 nasA nitrate transporter PA1791 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA1805 ppiD peptidyl-prolyl cis-trans isomerase D PA1817 hypothetical protein PA1819 probable amino acid permease PA1820 nhaB sodium/proton antiporter NhaB PA1824 conserved hypothetical protein PA1825 hypothetical protein PA1827 probable short-chain dehydrogenase PA1832 probable protease PA1848 probable MFS transporter PA1851 hypothetical protein PA1854 conserved hypothetical protein PA1856 probable cytochrome oxidase subunit PA1857 conserved hypothetical protein PA1862 modB molybdenum transport protein ModB PA1867 hypothetical protein PA1873 hypothetical protein PA1876 probable ATP-binding/permease fusion ABC transporter PA1877 probable secretion protein PA1882 probable transporter PA1883 probable NADH-ubiquinone/plastoquinone oxidoreductase PA1891 hypothetical protein PA1895 hypothetical protein PA1897 hypothetical protein PA1907 hypothetical protein PA1908 probable MFS transporter PA1909 hypothetical protein PA1916 probable amino acid permease PA1924 hypothetical protein PA1925 hypothetical protein PA1940 hypothetical protein PA1941 hypothetical protein PA1948 rbsC membrane protein component of ABC ribose transporter PA1958 probable transporter PA1959 bacA bacitracin resistance protein PA1960 hypothetical protein PA1963 hypothetical protein PA1971 braZ branched chain amino acid transporter BraZ PA1972 conserved hypothetical protein PA1993 probable MFS transporter PA2002 conserved hypothetical protein PA2006 probable MFS transporter PA2018 RND multidrug efflux transporter PA2026 conserved hypothetical protein PA2030 hypothetical protein PA2038 hypothetical protein PA2039 hypothetical protein PA2041 probable amino acid permease PA2042 probable transporter (membrane subunit) PA2051 probable transmembrane sensor PA2055 probable MFS transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA2060 probable permease of ABC transporter PA2068 probable MFS transporter PA2072 conserved hypothetical protein PA2073 probable transporter (membrane subunit) PA2079 probable amino acid permease PA2091 hypothetical protein PA2092 probable MFS transporter PA2094 probable transmembrane sensor PA2097 probable flavin-binding monooxygenase PA2101 conserved hypothetical protein PA2114 probable MFS transporter PA2122 hypothetical protein PA2136 hypothetical protein PA2148 conserved hypothetical protein PA2154 conserved hypothetical protein PA2170 hypothetical protein PA2175 hypothetical protein PA2178 hypothetical protein PA2183 hypothetical protein PA2187 hypothetical protein PA2195 hcnC hydrogen cyanide synthase HcnC PA2200 conserved hypothetical protein PA2202 probable amino acid permease PA2203 probable amino acid permease PA2207 hypothetical protein PA2208 hypothetical protein PA2210 probable MFS transporter PA2214 probable MFS transporter PA2219 opdE membrane protein OpdE PA2231 pslA probable glycosyl transferase PA2235 hypothetical protein PA2241 hypothetical protein PA2242 hypothetical protein PA2245 hypothetical protein PA2252 probable AGCS sodium/alanine/glycine symporter PA2262 probable 2-ketogluconate transporter PA2269 conserved hypothetical protein PA2278 arsB ArsB protein PA2284 hypothetical protein PA2285 hypothetical protein PA2287 hypothetical protein PA2306 conserved hypothetical protein PA2307 probable permease of ABC transporter PA2313 hypothetical protein PA2314 pvdH PvdH PA2322 gluconate permease PA2327 probable permease of ABC transporter PA2339 probable binding-protein-dependent maltose/mannitol transport protein PA2340 probable binding-protein-dependent maltose/mannitol transport protein PA2345 conserved hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA2351 probable permease of ABC transporter PA2362 hypothetical protein PA2388 probable transmembrane sensor PA2390 probable ATP-binding/permease fusion ABC transporter PA2393 probable dipeptidase precursor PA2397 pvdE pyoverdine biosynthesis protein PvdE PA2403 hypothetical protein PA2404 hypothetical protein PA2406 hypothetical protein PA2409 probable permease of ABC transporter PA2415 hypothetical protein PA2431 hypothetical protein PA2435 probable cation-transporting P-type ATPase PA2437 hypothetical protein PA2438 hypothetical protein PA2439 hypothetical protein PA2472 probable MFS transporter PA2477 probable thiol:disulfide interchange protein PA2494 mexF RND multidrug efflux transporter MexF PA2500 probable MFS transporter PA2501 hypothetical protein PA2520 czcA RND divalent metal cation efflux transporter CzcA PA2527 probable RND efflux transporter PA2533 probable sodium:alanine symporter PA2536 probable phosphatidate cytidylyltransferase PA2537 probable acyltransferase PA2538 hypothetical protein PA2541 probable CDP-alcohol phosphatidyltransferase PA2549 conserved hypothetical protein PA2558 probable transport protein PA2561 probable chemotaxis transducer PA2563 probable sulfate transporter PA2568 hypothetical protein PA2573 probable chemotaxis transducer PA2574 alkB1 alkane-1-monooxygenase PA2576 hypothetical protein PA2583 probable sensor/response regulator hybrid PA2584 pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PA2589 hypothetical protein PA2604 conserved hypothetical protein PA2615 ftsK cell division protein FtsK PA2628 hypothetical protein PA2635 hypothetical protein PA2637 nuoA NADH dehydrogenase I chain A PA2643 nuoH NADH dehydrogenase I chain H PA2645 nuoJ NADH dehydrogenase I chain J PA2646 nuoK NADH dehydrogenase I chain K PA2648 nuoM NADH dehydrogenase I chain M PA2649 nuoN NADH dehydrogenase I chain N PA2651 conserved hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA2654 probable chemotaxis transducer PA2662 conserved hypothetical protein PA2663 hypothetical protein PA2669 hypothetical protein PA2676 probable type II secretion system protein PA2678 probable permease of ABC-2 transporter PA2687 pfeS two-component sensor PfeS PA2701 probable MFS transporter PA2710 hypothetical protein PA2746 hypothetical protein PA2751 conserved hypothetical protein PA2752 conserved hypothetical protein PA2757 hypothetical protein PA2763 hypothetical protein PA2768 hypothetical protein PA2773 hypothetical protein PA2774 hypothetical protein PA2775 hypothetical protein PA2777 conserved hypothetical protein PA2782 hypothetical protein PA2784 hypothetical protein PA2788 probable chemotaxis transducer PA2789 hypothetical protein PA2791 hypothetical protein PA2803 hypothetical protein PA2810 probable two-component sensor PA2811 probable permease of ABC-2 transporter PA2815 probable acyl-CoA dehydrogenase PA2818 hypothetical protein PA2820 hypothetical protein PA2824 probable sensor/response regulator hybrid PA2830 htpX heat shock protein HtpX PA2835 probable MFS transporter PA2847 conserved hypothetical protein PA2858 conserved hypothetical protein PA2864 conserved hypothetical protein PA2867 probable chemotaxis transducer PA2868 hypothetical protein PA2873 hypothetical protein PA2874 hypothetical protein PA2880 hypothetical protein PA2883 hypothetical protein PA2884 hypothetical protein PA2916 hypothetical protein PA2919 hypothetical protein PA2920 probable chemotaxis transducer PA2924 hisQ histidine transport system permease HisQ PA2925 hisM histidine transport system permease HisM PA2929 hypothetical protein PA2933 probable MFS transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA2936 hypothetical protein PA2938 probable transporter PA2946 hypothetical protein PA2963 conserved hypothetical protein PA2973 probable peptidase PA2982 conserved hypothetical protein PA2983 probable tolQ-type transport protein PA2984 hypothetical protein PA2985 hypothetical protein PA2986 conserved hypothetical protein PA2988 conserved hypothetical protein PA2994 nqrF Na+-translocating NADH:quinone oxidoreductase, subunit Nqr6 PA2995 nqrE Na+-translocating NADH:quinone oxidoreductase subunit Nqr5 PA2996 nqrD Na+-translocating NADH:uniquinone oxidoreductase subunit Nqr4 PA2998 nqrB Na+-translocating NADH:ubiquinone oxidoreductase subunit Nrq2 PA3000 aroP1 aromatic amino acid transport protein AroP1 PA3012 hypothetical protein PA3039 probable transporter PA3041 hypothetical protein PA3042 hypothetical protein PA3058 pelG hypothetical protein PA3059 pelF hypothetical protein PA3061 pelD hypothetical protein PA3063 pelB hypothetical protein PA3065 hypothetical protein PA3072 hypothetical protein PA3073 hypothetical protein PA3074 hypothetical protein PA3078 probable two-component sensor PA3079 hypothetical protein PA3086 hypothetical protein PA3095 xcpZ general secretion pathway protein M PA3102 xcpS general secretion pathway protein F PA3104 xcpP secretion protein XcpP PA3106 probable short-chain dehydrogenase PA3109 hypothetical protein PA3110 hypothetical protein PA3136 probable secretion protein PA3137 probable MFS transporter PA3141 wbpM nucleotide sugar epimerase/dehydratase WbpM PA3147 wbpJ probable glycosyl transferase WbpJ PA3153 wzx O-antigen translocase PA3154 wzy B-band O-antigen polymerase PA3157 probable acetyltransferase PA3159 wbpA probable UDP-glucose/GDP-mannose dehydrogenase WbpA PA3160 wzz O-antigen chain length regulator PA3164 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE prephenate dehydrogenase PA3176 gltS sodium/glutamate symporter GltS PA3188 probable permease of ABC sugar transporter PA3189 probable permease of ABC sugar transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA3201 conserved hypothetical protein PA3210 trkH potassium uptake protein TrkH PA3211 probable permease of ABC transporter PA3213 hypothetical protein PA3216 hypothetical protein PA3217 cyaB CyaB protein PA3228 probable ATP-binding/permease fusion ABC transporter PA3231 hypothetical protein PA3235 conserved hypothetical protein PA3242 probable lauroyl acyltransferase PA3264 probable transporter PA3265 probable transporter PA3267 hypothetical protein PA3271 probable two-component sensor PA3275 conserved hypothetical protein PA3278 hypothetical protein PA3281 hypothetical protein PA3302 conserved hypothetical protein PA3303 probable MFS transporter PA3305 hypothetical protein PA3310 conserved hypothetical protein PA3311 conserved hypothetical protein PA3315 probable permease of ABC transporter PA3320 hypothetical protein PA3343 hypothetical protein PA3355 hypothetical protein PA3358 hypothetical protein PA3359 hypothetical protein PA3360 probable secretion protein PA3362 hypothetical protein PA3370 hypothetical protein PA3371 hypothetical protein PA3382 phnE phosphonate transport protein PhnE PA3386 conserved hypothetical protein PA3392 nosZ nitrous-oxide reductase precursor PA3395 nosY NosY protein PA3400 hypothetical protein PA3401 hypothetical protein PA3402 hypothetical protein PA3403 hypothetical protein PA3405 hasE metalloprotease secretion protein PA3406 hasD transport protein HasD PA3411 hypothetical protein PA3424 hypothetical protein PA3428 hypothetical protein PA3431 conserved hypothetical protein PA3432 hypothetical protein PA3436 hypothetical protein PA3443 probable permease of ABC transporter PA3448 probable permease of ABC transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA3457 hypothetical protein PA3465 conserved hypothetical protein PA3467 probable MFS transporter PA3468 conserved hypothetical protein PA3473 hypothetical protein PA3474 conserved hypothetical protein PA3489 conserved hypothetical protein PA3492 conserved hypothetical protein PA3494 conserved hypothetical protein PA3522 probable RND efflux transporter PA3532 hypothetical protein PA3536 hypothetical protein PA3541 alg8 alginate biosynthesis protein Alg8 PA3542 alg44 alginate biosynthesis protein Alg44 PA3548 algI alginate o-acetyltransferase AlgI PA3549 algJ alginate o-acetyltransferase AlgJ PA3553 probable glycosyl transferase PA3557 conserved hypothetical protein PA3560 fruA phosphotransferase system, fructose-specific IIBC component PA3575 hypothetical protein PA3581 glpF glycerol uptake facilitator protein PA3585 glpM membrane protein GlpM PA3590 probable hydroxyacyl-CoA dehydrogenase PA3595 probable MFS transporter PA3597 probable amino acid permease PA3602 conserved hypothetical protein PA3603 dgkA diacylglycerol kinase PA3605 hypothetical protein PA3608 potB polyamine transport protein PotB PA3609 potC polyamine transport protein PotC PA3631 conserved hypothetical protein PA3634 conserved hypothetical protein PA3638 conserved hypothetical protein PA3641 probable amino acid permease PA3649 conserved hypothetical protein PA3651 cdsA phosphatidate cytidylyltransferase PA3660 probable sodium/hydrogen antiporter PA3665 hypothetical protein PA3671 probable permease of ABC transporter PA3676 probable RND efflux transporter PA3690 probable metal-transporting P-type ATPase PA3694 hypothetical protein PA3709 probable MFS transporter PA3712 hypothetical protein PA3718 probable MFS transporter PA3729 conserved hypothetical protein PA3730 hypothetical protein PA3734 hypothetical protein PA3739 probable sodium/hydrogen antiporter PA3747 conserved hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA3748 conserved hypothetical protein PA3749 probable MFS transporter PA3761 probable phosphotransferase system protein PA3766 probable aromatic amino acid transporter PA3768 probable metallo-oxidoreductase PA3771 probable transcriptional regulator PA3775 hypothetical protein PA3780 hypothetical protein PA3781 probable transporter PA3788 hypothetical protein PA3789 hypothetical protein PA3791 hypothetical protein PA3792 leuA 2-isopropylmalate synthase PA3794 hypothetical protein PA3801 conserved hypothetical protein PA3804 hypothetical protein PA3820 secF secretion protein SecF PA3822 conserved hypothetical protein PA3825 hypothetical protein PA3826 hypothetical protein PA3827 conserved hypothetical protein PA3828 conserved hypothetical protein PA3837 probable permease of ABC transporter PA3839 probable sodium:sulfate symporter PA3848 hypothetical protein PA3851 hypothetical protein PA3857 pcs phosphatidylcholine synthase PA3872 narI respiratory nitrate reductase gamma chain PA3876 narK2 nitrite extrusion protein 2 PA3877 narK1 nitrite extrusion protein 1 PA3878 narX two-component sensor NarX PA3881 hypothetical protein PA3884 hypothetical protein PA3887 nhaP Na+/H+ antiporter NhaP PA3888 probable permease of ABC transporter PA3890 probable permease of ABC transporter PA3893 conserved hypothetical protein PA3897 hypothetical protein PA3920 probable metal transporting P-type ATPase PA3926 probable MFS transporter PA3928 hypothetical protein PA3929 cioB cyanide insensitive terminal oxidase PA3930 cioA cyanide insensitive terminal oxidase PA3933 probable choline transporter PA3934 conserved hypothetical protein PA3936 probable permease of ABC taurine transporter PA3955 hypothetical protein PA3958 hypothetical protein PA3963 probable transporter PA3964 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA3966 hypothetical protein PA3984 lnt apolipoprotein N-acyltransferase PA3985 conserved hypothetical protein PA4002 rodA rod shape-determining protein PA4003 pbpA penicillin-binding protein 2 PA4011 hypothetical protein PA4013 conserved hypothetical protein PA4014 hypothetical protein PA4023 probable transport protein PA4029 conserved hypothetical protein PA4036 probable two-component sensor PA4038 hypothetical protein PA4039 hypothetical protein PA4041 hypothetical protein PA4046 hypothetical protein PA4050 pgpA phosphatidylglycerophosphatase A PA4072 probable amino acid permease PA4082 cupB5 adhesive protein CupB5 PA4083 cupB4 chaperone CupB4 PA4093 hypothetical protein PA4096 probable MFS transporter PA4103 hypothetical protein PA4104 conserved hypothetical protein PA4112 probable sensor/response regulator hybrid PA4113 probable MFS transporter PA4126 probable MFS transporter PA4131 probable iron-sulfur protein PA4133 cytochrome c oxidase subunit (cbb3-type) PA4134 hypothetical protein PA4136 probable MFS transporter PA4141 hypothetical protein PA4142 probable secretion protein PA4143 probable toxin transporter PA4170 hypothetical protein PA4180 probable acetolactate synthase large subunit PA4187 probable MFS transporter PA4190 pqsL probable FAD-dependent monooxygenase PA4193 probable permease of ABC transporter PA4194 probable permease of ABC transporter PA4205 mexG hypothetical protein PA4207 mexI probable RND efflux transporter PA4218 probable transporter PA4219 hypothetical protein PA4222 probable ATP-binding component of ABC transporter PA4223 probable ATP-binding component of ABC transporter PA4233 probable MFS transporter PA4243 secY secretion protein SecY PA4276 secE secretion protein SecE PA4287 hypothetical protein PA4289 probable transporter Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA4290 probable chemotaxis transducer PA4292 probable phosphate transporter PA4294 hypothetical protein PA4295 hypothetical protein PA4297 hypothetical protein PA4300 hypothetical protein PA4306 hypothetical protein PA4307 pctC chemotactic transducer PctC PA4310 pctB chemotactic transducer PctB PA4313 hypothetical protein PA4317 hypothetical protein PA4318 hypothetical protein PA4319 conserved hypothetical protein PA4320 hypothetical protein PA4332 hypothetical protein PA4334 probable transport protein PA4338 hypothetical protein PA4343 probable MFS transporter PA4358 probable ferrous iron transport protein PA4365 probable transporter PA4368 hypothetical protein PA4369 hypothetical protein PA4375 probable RND efflux transporter PA4380 probable two-component sensor PA4382 hypothetical protein PA4383 conserved hypothetical protein PA4387 conserved hypothetical protein PA4393 probable permease PA4394 conserved hypothetical protein PA4398 probable two-component sensor PA4404 hypothetical protein PA4409 ftsQ cell division protein FtsQ PA4411 murC UDP-N-acetylmuramate--alanine ligase PA4413 ftsW cell division protein FtsW PA4415 mraY phospho-N-acetylmuramoyl-pentapeptide-transferase PA4418 ftsI penicillin-binding protein 3 PA4419 ftsL cell division protein FtsL PA4430 probable cytochrome b PA4441 hypothetical protein PA4446 algW AlgW protein PA4454 conserved hypothetical protein PA4455 probable permease of ABC transporter PA4467 hypothetical protein PA4476 hypothetical protein PA4479 mreD rod shape-determining protein MreD PA4491 conserved hypothetical protein PA4494 probable two-component sensor PA4503 probable permease of ABC transporter PA4504 probable permease of ABC transporter PA4507 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA4512 lpxO1 lipopolysaccharide biosynthetic protein LpxO1 PA4513 probable oxidoreductase PA4517 conserved hypothetical protein PA4520 probable chemotaxis transducer PA4521 hypothetical protein PA4527 pilC still frameshift type 4 fimbrial biogenesis protein PilC PA4528 pilD type 4 prepilin peptidase PilD PA4532 hypothetical protein PA4537 hypothetical protein PA4541 hypothetical protein PA4546 pilS two-component sensor PilS PA4559 lspA prolipoprotein signal peptidase PA4562 conserved hypothetical protein PA4565 proB glutamate 5-kinase PA4574 conserved hypothetical protein PA4593 probable permease of ABC transporter PA4596 probable transcriptional regulator PA4598 mexD RND multidrug efflux transporter MexD PA4600 nfxB transcriptional regulator NfxB PA4601 conserved hypothetical protein PA4606 conserved hypothetical protein PA4610 hypothetical protein PA4614 mscL conductance mechanosensitive channel PA4622 probable MFS transporter PA4628 lysP lysine-specific permease PA4629 hypothetical protein PA4633 probable chemotaxis transducer PA4635 conserved hypothetical protein PA4637 hypothetical protein PA4640 mqoB malate:quinone oxidoreductase PA4647 uraA uracil permease PA4654 probable MFS transporter PA4663 moeB molybdopterin biosynthesis MoeB protein PA4689 hypothetical protein PA4690 still frameshift hypothetical protein PA4691 hypothetical protein PA4693 pssA phosphatidylserine synthase PA4700 mrcB penicillin-binding protein 1B PA4707 probable permease of ABC transporter PA4713 hypothetical protein PA4717 conserved hypothetical protein PA4719 probable transporter PA4724 probable aminoacyl-transfer RNA synthetase (class I) PA4725 cbrA two-component sensor CbrA PA4735 hypothetical protein PA4747 secG secretion protein SecG PA4754 hypothetical protein PA4757 conserved hypothetical protein PA4770 lldP L-lactate permease PA4779 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA4804 probable amino acid permease PA4810 fdnI nitrate-inducible formate dehydrogenase, gamma subunit PA4819 probable glycosyl transferase PA4820 hypothetical protein PA4821 probable transporter PA4822 hypothetical protein PA4825 mgtA Mg(2+) transport ATPase, P-type 2 PA4828 conserved hypothetical protein PA4833 conserved hypothetical protein PA4835 hypothetical protein PA4838 hypothetical protein PA4842 hypothetical protein PA4849 hypothetical protein PA4851 hypothetical protein PA4857 hypothetical protein PA4859 probable permease of ABC transporter PA4860 probable permease of ABC transporter PA4863 hypothetical protein PA4871 hypothetical protein PA4883 hypothetical protein PA4887 probable MFS transporter PA4888 conserved hypothetical protein PA4895 probable transmembrane sensor PA4900 probable MFS transporter PA4903 probable MFS transporter PA4911 probable permease of ABC branched-chain amino acid transporter PA4912 probable permease of ABC branched chain amino acid transporter PA4925 conserved hypothetical protein PA4929 hypothetical protein PA4940 conserved hypothetical protein PA4941 hflC protease subunit HflC PA4942 hflK protease subunit HflK PA4953 motB chemotaxis protein MotB PA4954 motA chemotaxis protein MotA PA4961 hypothetical protein PA4962 conserved hypothetical protein PA4965 hypothetical protein PA4981 probable amino acid permease PA4982 probable two-component sensor PA4990 SMR multidrug efflux transporter PA4997 msbA transport protein MsbA PA4999 hypothetical protein PA5002 hypothetical protein PA5021 probable sodium/hydrogen antiporter PA5024 conserved hypothetical protein PA5030 probable MFS transporter PA5042 pilO type 4 fimbrial biogenesis protein PilO PA5043 pilN type 4 fimbrial biogenesis protein PilN PA5045 ponA penicillin-binding protein 1A PA5052 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA5065 ubiB ubiquinone biosynthetic protein UbiB PA5068 tatA translocation protein TatA PA5070 tatC transport protein TatC PA5072 probable chemotaxis transducer PA5075 probable permease of ABC transporter PA5077 mdoH periplasmic glucans biosynthesis protein MdoH PA5095 probable permease of ABC transporter PA5097 probable amino acid permease PA5099 probable transporter PA5102 hypothetical protein PA5114 hypothetical protein PA5126 hypothetical protein PA5130 conserved hypothetical protein PA5132 hypothetical protein PA5151 hypothetical protein PA5154 probable permease of ABC transporter PA5155 probable permease of ABC transporter PA5160 drug efflux transporter PA5165 probable two-component sensor PA5168 probable dicarboxylate transporter PA5170 arcD arginine/ornithine antiporter PA5181 probable oxidoreductase PA5182 hypothetical protein PA5194 hypothetical protein PA5199 envZ two-component sensor EnvZ PA5205 conserved hypothetical protein PA5211 conserved hypothetical protein PA5216 probable permease of ABC iron transporter PA5230 probable permease of ABC transporter PA5231 probable ATP-binding/permease fusion ABC transporter PA5232 conserved hypothetical protein PA5235 glpT glycerol-3-phosphate transporter PA5238 probable O-antigen acetylase PA5244 conserved hypothetical protein PA5250 conserved hypothetical protein PA5251 hypothetical protein PA5256 dsbH disulfide bond formation protein PA5257 hypothetical protein PA5258 hypothetical protein PA5262 algZ alginate biosynthesis protein AlgZ/FimS PA5264 hypothetical protein PA5265 hypothetical protein PA5268 corA magnesium/cobalt transport protein PA5270 hypothetical protein PA5273 hypothetical protein PA5291 probable choline transporter PA5294 hypothetical protein PA5311 probable MFS transporter PA5333 conserved hypothetical protein PA5341 hypothetical protein Supplementary Table 5. Proteins predicted to use a transmembrane helix for membrane targeting. PAID Gene Protein PA5358 ubiA 4-hydroxybenzoate-octaprenyl transferase PA5361 phoR two-component sensor PhoR PA5362 conserved hypothetical protein PA5367 pstA membrane protein component of ABC phosphate transporter PA5368 pstC membrane protein component of ABC phosphate transporter PA5370 probable MFS transporter PA5377 probable permease of ABC transporter PA5383 conserved hypothetical protein PA5385 hypothetical protein PA5394 cls cardiolipin synthase PA5399 probable ferredoxin PA5402 hypothetical protein PA5409 hypothetical protein PA5412 hypothetical protein PA5424 conserved hypothetical protein PA5430 hypothetical protein PA5434 mtr tryptophan permease PA5442 conserved hypothetical protein PA5451 wzm membrane subunit of A-band LPS efflux transporter PA5458 hypothetical protein PA5466 hypothetical protein PA5469 conserved hypothetical protein PA5473 conserved hypothetical protein PA5476 citA citrate transporter PA5477 hypothetical protein PA5479 gltP proton-glutamate symporter PA5482 hypothetical protein PA5484 probable two-component sensor PA5486 conserved hypothetical protein PA5504 probable permease of ABC transporter PA5510 probable transporter PA5515 hypothetical protein PA5517 conserved hypothetical protein PA5529 probable sodium/proton antiporter PA5530 probable MFS dicarboxylate transporter PA5544 conserved hypothetical protein PA5548 probable MFS transporter PA5558 atpF ATP synthase B chain PA5559 atpE atp synthase C chain PA5560 atpB ATP synthase A chain PA5561 atpI ATP synthase protein I PA5568 conserved hypothetical protein