Patents & IP Sequences | Clinical Trials | Drug Pipelines I. How we used VP-SCE in the COVID-19 Case Study. II. Changes coming in Version 12.

February 10, 2021 Matt Eberle Lead Developer, Analytics & Custom Solutions www.bizint.com Commonly Used Features – COVID- 19 Case Study Examples

• Extract Highest Phase for Indication • List Cleanup – Cleanup Indications • Filter Drug Development Phase • Thesauri – • Create a category field (vaccine type) • Filter out unmatched terms • Thesaurus editor for easy updates • Create a sub-Dataset • Visualizations (Bullseye, Milestone Timeline) • Further Processing – • Divide multiple item fields • Cleanup dates • Concatenate & Merge Fields – combine related fields from different sources • My Keywords – term extraction New in Visualizations - VP-SCE 12

• Milestone Timeline • Brand new • Combines features of Event and Duration Timelines • Bullseye • Updated design • Piano • Split long columns into two • Inverted bottom to top • Color palette choices • More new visualizations • Multi donut • Scatter Plot • Butterfly Chart The Goal Inactivated Live-attenuated COVI-VAC - Codagenix ERUCOV-VAC - Health Inst Turkey modified Antigen-Presenting Cell (APC) Immune cell aAPC Vaccine - Shenzhen Geno-Immune VLA2001 - Valneva Protein subunit DNA AV-COVID-19 - Aivita V-SARS - Immunitor COVAX 19 - GeneCure Covigenix VAX-001 - Entos/CIHR - Bharat Biotech LV-SMENP-DC - Shenzhen Geno-Immune Allostim - Immunovative/Mirror COVID-19 vaccine - Chinese Acad Med Sci COVID-19 vaccine - Chinese CDC GX-19N - Genexine QazCovid-in - RIBSP COVID-19 vaccine - Sinopharm CORVax - OncoSec MVC-COV1901 - Medigen Coronavac - Sinovac AdimrSC-2f - AdImmune GLS-5310 - GeneOne NVX CoV 2373 - Novavax AG0302 - AnGes AKS-452 - Akston INO 4800 - Inovio bacTRL-Spike - Symvivo SCB 2019 - Clover/GSK AG0301 - AnGes COVAC-2 - VIDO-InterVac VLP vaccine - Medicago CoVac-1 - Univ Hosp Tuebingen Virus-like Particle COVID-19 vaccine - Sanofi/GSK BNT 162 - BioNTech/Pfizer Ad26.COV2.S - J&J UB-612 United Biomedical/COVAXX IIBR-100 - IIBR mRNA 1273 - Moderna/NIH VXA-CoV2-1 - Vaxart EpiVacCorona - VECTOR AZD 1222- AstraZeneca/Oxford ZF2001 - Anhui Zhifei Longcom/Chinese Acad Sci Ad5-nCoV - CanSino Viral vector COVID-19 vaccine - ZHONGYIANKE AdCLD-CoV19 - Cellid KBP-COVID-19 - Kentucky BioProcessing CVnCoV - CureVac Gam-COVID-Vac - Gamaleya V590 - Merck & Co. - Nanogen V591 - Merck & Co. MVA-SARS-2-S - UKE UQ-1 Sclamp vaccine - Syneos/CEPI AZD1222/rAd26-S AstraZeneca/Gamaleya ARCT-021 - Arcturus GRAd-COV2 - ReiThera

ChulaCov19 - Chula VRC COH04S1 - City of Hope RNA hAd5-S-Fusion+N-ETSD - ImmunityBio The Challenge ClinicalTrials.gov doesn’t: • categorize by type or technology. • reliably identify vaccines as vaccines. Ok, the Challenges. ClinicalTrials.gov also doesn’t: • Use a standardized name for each vaccine • Use a standardized company name. • Identify the owner company as a trial sponsor

VP-SCE can help with these too. But- one problem at a time The Solution We need to create a category field. Thesauri – Create a category field Thesauri – Categorize an added vaccine Thesauri – Apply the thesaurus to categorize by vaccine type

Uncheck to filter out unmatched terms Thesauri – From vaccine & sponsor to Vaccine type Filtering – Create Sub-dataset Filtering – Create Sub-dataset Create the bullseye COVID-19 Vaccine Landscape VP-SCE Bullseye℠ Inactivated Live-attenuated COVI-VAC - Codagenix ERUCOV-VAC - Health Inst Turkey Modified Antigen-Presenting Cell (APC) Immune cell aAPC Vaccine - Shenzhen Geno-Immune Phase 1 VLA2001 - Valneva AV-COVID-19 - Aivita V-SARS - Immunitor Phase 2 COVAX 19 - GeneCure Covigenix VAX-001 - Entos/CIHR Covaxin - Bharat Biotech LV-SMENP-DC - Shenzhen Geno-Immune Allostim - Immunovative/Mirror Phase 3 COVID-19 vaccine - Chinese Acad Med Sci COVID-19 vaccine - Chinese CDC GX-19N - Genexine DNA QazCovid-in - RIBSP COVID-19 vaccine - Sinopharm Authorized CORVax - OncoSec MVC-COV1901 - Medigen Coronavac - Sinovac AdimrSC-2f - AdImmune GLS-5310 - GeneOne NVX CoV 2373 - Novavax AG0302 - AnGes Phase change AKS-452 - Akston Protein subunit INO 4800 - Inovio bacTRL-Spike - Symvivo New this update SCB 2019 - Clover/GSK AG0301 - AnGes COVAC-2 - VIDO-InterVac Efficacy Results Announced CoVac-1 - Univ Hosp Tuebingen VLP vaccine - Medicago Virus-like particle Emergency Use COVID-19 vaccine - Sanofi/GSK BNT 162 - BioNTech/Pfizer Ad26.COV2.S - J&J Authorization UB-612 United Biomedical/COVAXX IIBR-100 - IIBR (EUA) Requested mRNA 1273 - Moderna/NIH VXA-CoV2-1 - Vaxart EpiVacCorona - VECTOR AZD 1222- AstraZeneca/Oxford EUA Granted ZF2001 - Anhui Zhifei Longcom/Chinese Acad Sci Ad5-nCoV - CanSino COVID-19 vaccine - ZHONGYIANKE AdCLD-CoV19 - Cellid KBP-COVID-19 - Kentucky BioProcessing V590 - Merck & Co. CVnCoV - CureVac Gam-COVID-Vac - Gamaleya Nanocovax - Nanogen V591 - Merck & Co. Viral vector MVA-SARS-2-S - UKE UQ-1 Sclamp vaccine - Syneos/CEPI AZD1222/rAd26-S AstraZeneca/Gamaleya ARCT-021 - Arcturus GRAd-COV2 - ReiThera Updated January 26, 2021 ChulaCov19 - Chula VRC COH04S1 - City of Hope Source: ClinicalTrials.gov Learn more at bizint.com/COVID RNA hAd5-S-Fusion+N-ETSD - ImmunityBio Created with VantagePoint – Smart Charts Edition (VP-SCE) COVID-19 Vaccine Landscape - pipeline Live-attenuated Launched modified Antigen-Presenting Cell (APC) COVI-VAC - Codagenix Inactivated Preregistration aAPC Vaccine - Shenzhen Geno-Immune ERUCOV-VAC - Health Inst Turkey Protein subunit AV-COVID-19 - Aivita Phase 3 AdimrSC-2f - AdImmune VLA2001 - Valneva COVID-19 - Shifa Pharmed Phase 2 COVID-19 vaccine - M P Chumakov Inst LV-SMENP-DC - Shenzhen Geno-Immune Phase 1 COVID-19 vaccine - Beijing Minhai CoVac-1 - Univ Hosp Tuebingen QazCovid-in - RIBSP DNA S 268019 - UMN CoronaVac - Sinovac COVID-19 vaccine - BioNet-Asia COVAC-2 - VIDO-InterVac COVAX 19 - GeneCure COVID-19 vaccine - Chinese Acad Med Sci BBIBP-CorV - Sinopharm COVID-19 vaccine - Chinese CDC GX-19N - Genexine Covaxin - Bharat Biotech CORVax - OncoSec Covovax - Novavax ZyCoV-D - Zydus Cadila COVID-19 vaccine - Razi COVID-2019 vaccine - Biological E INO 4800 - Inovio GLS-5310 - GeneOne KBP-COVID-19 - Kentucky BioProcessing bacTRL-Spike - Symvivo EpiVacCorona - VECTOR AG0302 - AnGes FINLAY-FR-2 - Finlay Inst MVC-COV1901 - Medigen VLP vaccine - Medicago Virus-like particle Sputnik V - Gamaleya HBsAg VLP vaccine - SpyBiotech BNT 162 - BioNTech/Pfizer AZD 1222 - AstraZeneca/Oxford GBP-510 - SK Bioscience Nanocovax - Nanogen mRNA 1273 - Moderna/NIH COVID-19 vaccine - Serum Inst India ZF2001 - Anhui Zhifei Longcom/Chinese Acad Sci Ad26.COV2.S - J&J T-COVID - Altimmune SP-0253 - Sanofi/GSK RBD-Fc Vacc - Zhongyi Anke VXA-CoV2-1 - Vaxart Ad5-nCoV - CanSino CVnCoV - CureVac NasoVAX - Altimmune UB-612 - United Biomedical/COVAXX Viral vector SCB 2019 - Clover/GSK IIBR-100 - IIBR V-SARS - Immunitor hAd5-S-Fusion+N-ETSD - ImmunityBio AdCLD-CoV19 - Cellid XWG-03 - Xiamen Innovax Ad5 COVID-19 - ImmunityBio ARCT-021 - Arcturus ARCoV - Suzhou Abogen/Walvax GRAd-COV2 - ReiThera saRNA vaccine - Imperial Coll London PTX-COVID19-B - Providence RNA COH04S1 - City of Hope Enhance your tabular reports Data can be sent round trip between tools. New in Visualizations - VP-SCE 12

• Milestone Timeline • Brand new! • Combines features of Event and Duration Timelines • Bullseye • Updated design • Option to show count for each slice • Option to choose which phases to show regardless of content • Piano • Split long columns into two • Inverted bottom to top • Color palette choices • More new visualizations • Multi donut • Scatter Plot • Butterfly Chart Beyond visualizations

• Filter Drug Development Phase – Easily create a Drug Development Phase table for a single indication, or for a few key indications • Filter by Selected – Filter any field by a selection • Create Field from Each Group – Create groups and then create a new field for each group. Milestone Timeline Milestone Timeline Milestone Timeline Milestone Timeline Patents & IP Sequences | Clinical Trials | Drug Pipelines Thank You! Questions? I have some, so you can help me with our case study… COVID-19 Vaccine Landscape - pipeline What phase is a vaccine at when roll-out is underway? What if it’s only available in Russia? The pipeline data says Launched (and also Registration and Preregistration.) Where would you place Pfizer? Moderna? AZ? Gamaleya? COVID-19 Vaccine Landscape - pipeline

With pipeline data we found more vaccines, but some vaccines are also missing. Why? When do we list a vaccine at a phase? When the trial is announced, or when it starts? COVID-19 Vaccine Landscape - pipeline

What gets marked New? Moving from Preclinical to Phase 1? Newly identified by the source databases?