Gene name Entrez Gene ID Gene Symbol Agilent Probe ID 06-0121A (XP)06-0678A-244k06-0694A-244k06-0747A-244k06-0756A-244k06-1067A-244k Keratin 6B 3854 KRT6B A_23_P76249 0.002 3.722 3.952 2.942 -2.848 1.802 Interleukin 1, beta 3553 IL1B A_23_P79518 -0.325 2.295 3.585 2.305 1.655 2.655 A_24_P932736 1.114 -1.286 -2.226 -2.306 -2.256 -2.056 Transcribed locus A_32_P134634 0.139 -2.162 -1.871 -2.002 -1.152 -1.412 Nuclear receptor subfamily 4, group8013 A, member NR4A3 3 A_23_P398566 -0.511 3.753 4.437 2.092 1.232 1.905 MUC5B A_24_P102650 0.266 -0.338 -0.348 -0.518 -0.258 -1.118 Thrombospondin 1 7057 A_24_P142118 -0.596 2.691 1.581 1.021 2.011 1.791 Calpain 6 827 CAPN6 A_23_P217570 -0.644 0.494 -0.036 0.262 -0.608 1.379 Paired-like homeodomain transcription5307 factor PITX1 1 A_23_P58642 0.231 -0.575 -0.385 -0.825 -0.085 -0.555 Cysteine-rich, angiogenic inducer, 613491 CYR61 A_23_P46426 -1.016 2.32 2.77 1.82 2.11 2.709 Laminin, gamma 2 3918 LAMC2 A_23_P201636 -0.583 2.495 3.695 2.355 -0.835 3.075 Indoleamine-pyrrole 2,3 dioxygenase3620 INDO A_23_P112026 -1.329 -0.39 -2.49 -1.43 -1.31 -0.68 A_24_P506680 1.962 -0.8 2.49 0.73 0.409 0.81 A_32_P171043 -1.85 2.115 1.405 1.995 1.075 1.975 Cerebral protein 11 9911 TMCC2 A_32_P133840 2.852 0.123 2.479 0.035 -0.235 -0.429 Chondroitin polymerizing factor 79586 CHPF A_23_P131289 -0.007 -0.341 -0.391 -0.252 -0.022 -0.492 Hypothetical gene supported by BC048329389332 LOC389332 A_24_P289665 -0.383 0 0.08 -0.12 0.08 0 CD86 antigen (CD28 antigen ligand 2,942 B7-2 CD86 antigen) A_24_P131589 1.81 -0.664 -2.954 -2.174 -3.17 -2.383 TMEM139 A_32_P208599 -0.081 -0.17 -0.001 -0.2 -0.16 -0.35 A_24_P375205 1.989 0.391 2.811 0.951 0.261 0.891 Calcium binding protein 7 164633 CABP7|ZMAT5A_24_P177236 0.44 -0.492 -1.046 -1.303 -0.811 -1.421 Fatty acid binding protein 4, adipocyte2167 FABP4 A_23_P8812 2.679 2.558 2.028 1.92 2.418 0.425 A_24_P681266 2.479 3.172 3.352 1.732 1.592 1.692 Epididymal sperm binding protein 164100 ELSPBP1 A_23_P33664 -0.441 1.36 1.57 1.85 2.31 1.67 A_32_P211253 -0.184 -0.265 -0.025 -0.135 -0.325 -0.794 S100 calcium binding protein A8 (calgranulin6279 S100A8 A) A_23_P434809 1.167 1.782 2.483 -0.291 0.21 0.291 Apobec-1 complementation factor 29974 ACF A_23_P104224 0.502 0.088 0.028 -0.202 0.008 -0.012 High mobility group AT-hook 1 3159 HMGA1 A_24_P222043 -0.353 -0.104 0.066 -0.254 0.106 -0.325 Nucleophosmin/nucleoplasmin, 2 10361 NPM2 A_23_P169007 -0.334 -0.364 -0.254 -0.393 -0.104 -0.134 Transcribed locus A_32_P2605 0.119 -2.057 -0.637 -1.447 -1.747 -1.987 Leucine rich repeat containing 2 79442 LRRC2 A_23_P155463 0.536 -0.465 -2.192 -0.869 -1.475 -1.369 Thrombospondin 1 7057 THBS1 A_23_P206212 -0.87 2.14 1.01 0.5 1.8 1.12 Potassium inwardly-rectifying channel,3772 subfamily KCNJ15 J, memberA_23_P17655 15 -0.321 2.048 1.858 1.049 1.458 1.009 Keratin 6E 286887 KRT6C A_23_P366936 -0.502 1.444 1.988 1.37 -1.278 1.449 KRT14P|LOC400578|MGC102966A_32_P62963 0.494 1.367 1.847 1.827 -2.712 1.638 A_23_P72252 -1.132 -1.396 -1.055 -0.675 -1.646 1.395 KIAA1115 22870 SAPS1 A_23_P119448 0.506 -0.427 -1.555 -1.554 -1.043 -1.772 Inhibin, beta A (activin A, activin AB3624 alpha polypeptide) A_24_P535256 -1.102 2.148 1.538 2.128 0.848 1.688 Coagulation factor III (thromboplastin,2152 tissue F3 factor) A_23_P126782 -0.2 0.751 0.981 0.181 0.551 0.511 A_32_P199824 1.024 -1.122 -2.079 -1.767 -1.743 -1.079 Connective tissue growth factor 1490 CTGF A_23_P19663 -0.767 1.67 0.58 0.69 -0.27 0.86 MRNA; cDNA DKFZp666D074 (from clone LOC728965 DKFZp666D074) A_32_P164917 -0.617 -1.153 -0.663 -1.243 0.717 -1.333 Chemokine (C-X-C motif) ligand 14 9547 CXCL14 A_23_P213745 -0.529 1.526 1.836 1.456 2.236 1.636 A_24_P153035 0.33 1.519 1.979 1.859 -3.041 1.379 Annexin A8 244 ANXA8L2|ANXA8|ANXA8L1|LOC652846A_23_P395054 1.607 0.228 0.898 0.958 -0.692 2.608 Keratin 14 (epidermolysis bullosa simplex,3861 KRT14 Dowling-Meara, A_23_P4335 Koebner) 0.635 1.556 2.106 1.766 -1.904 1.396 Keratin 6A 3853 KRT6A A_23_P87653 -0.33 1.269 1.776 1.205 -0.778 0.961 A_32_P44932 -1.942 -0.228 -0.009 -0.009 -1.049 -0.738 Keratin associated protein 1-1 81851 LOC728255|LOC728946|LOC730743|KRTAP1-1|LOC728952A_24_P151005 0.215 0.115 -0.045 -0.165 0.005 -0.195 MRNA; cDNA DKFZp666D074 (from clone LOC728965 DKFZp666D074) A_32_P164916 -0.67 -1.034 -0.704 -1.344 0.516 -1.334 Lymphoid nuclear protein related to 3899AF4 AFF3 A_24_P366670 -0.188 -0.654 -0.314 -0.284 -0.294 -0.464 Laminin, alpha 3 3909 LAMA3 A_23_P89780 -0.954 2.077 3.526 1.907 0.007 2.436 Chemokine (C-X-C motif) ligand 1 (melanoma2919 CXCL1 growth stimulatingA_23_P7144 activity, alpha) 0.027 0.204 2.329 1.202 -0.075 1.874 Protocadherin 8 5100 PCDH8 A_23_P36985 1.473 1.577 2.277 0.977 0.627 1.637 DKFZP434I092 protein 26166 RGS22 A_32_P125771 0.339 -1.722 -2.132 -0.792 0.318 -2.282 Osteoglycin (osteoinductive factor, mimecan)4969 OGN A_23_P82990 -0.695 1.79 0.88 1.51 0.319 1.099 Prostaglandin-endoperoxide synthase5743 2 (prostaglandin PTGS2 G/HA_24_P250922 synthase and cyclooxygenase)-1.181 1.499 2.939 2.025 0.132 2.928 Suppression of tumorigenicity 18 (breast9705 carcinoma) ST18 (zincA_23_P31858 finger protein) -0.817 -1.037 2.532 0.842 0.009 0.521 COX7B A_32_P127454 0.848 0.032 2.202 0.532 -0.178 0.272 Cysteine-rich, angiogenic inducer, 613491 CYR61 A_23_P46429 -1.075 2.002 2.282 1.482 1.982 2.192 Tumor protein p73-like 8626 TP63 A_23_P327380 -0.634 1.766 3.436 1.997 -4.494 2.827 Fibroblast activation protein, alpha 2191 FAP A_23_P56746 -0.758 2.667 0.567 2.087 0.767 1.557 Latent transforming growth factor beta4053 binding LTBP2 protein 2 A_23_P405129 -0.026 1.831 2.04 1.185 0.321 1.59 A_32_P10403 0.581 3.119 1.329 0.349 1.009 0.579 Gremlin 1 homolog, cysteine knot superfamily26585 GREM1 (Xenopus A_23_P432947 laevis) -2.231 1.709 0.679 1.858 0.347 2.187 A_24_P928031 -0.205 -0.857 2.594 0.744 0.127 1.176 Carcinoembryonic antigen-related cell4680 adhesion CEACAM6 molecule A_23_P421483 6 (non-specific cross reacting0.47 antigen)-1.992 -0.642 -1.462 -0.636 -0.642 Reversion-inducing-cysteine-rich protein8434 with RECK kazal motifsA_23_P83028 -0.759 1.488 0.968 1.758 0.618 0.848 Interleukin 13 receptor, alpha 2 3598 IL13RA2 A_23_P85209 -1.382 2.966 1.716 2.106 0.646 1.616 A_32_P80016 0.648 -1.309 -1.785 -1.596 -1.779 -2.194 Colony stimulating factor 3 (granulocyte)1440 CSF3 A_23_P501754 -0.571 0.815 1.007 -0.386 1.586 1.159 Hemoglobin, beta 3043 HBB A_23_P203558 1.977 1.767 1.076 1.691 1.347 0.407 Eyes absent homolog 4 (Drosophila)2070 EYA4 A_23_P145507 -0.005 0.536 0.193 0.542 3.112 1.01 EGF-like-domain, multiple 6 25975 EGFL6 A_23_P22596 1.39 -2.177 -0.917 -1.397 1.443 -1.417 Tissue factor pathway inhibitor 2 7980 TFPI2 A_23_P393620 -1.346 -1.91 -0.572 -0.572 -0.534 -1.825 Homeo box B13 10481 HOXB13 A_23_P4212 -0.197 -0.367 2.473 1.483 1.113 1.593 AT rich interactive domain 3A (BRIGHT-1820 like) ARID3A A_23_P16516 -0.278 -0.405 -0.736 -0.346 0.264 -0.566 A_23_P33356 0.103 1.794 1.964 0.064 0.624 0.474 Cysteine-rich, angiogenic inducer, 613491 CYR61 A_24_P370946 -0.979 1.655 2.105 1.432 2.025 1.655 Plasminogen 5340 SLC22A3|PLGA_32_P206123 0.139 1.19 1.34 1.17 0.85 1.08 CDNA FLJ35379 fis, clone SKMUS2006481 FLJ35379 A_24_P341000 0.047 -0.138 1.922 0.4 -0.339 0.236 Laminin, gamma 2 3918 LAMC2 A_23_P160968 -0.389 0.907 1.857 0.557 -1.003 2.027 Formyl peptide receptor 1 2357 A_23_P38795 0.088 0.978 1.268 0.758 0.108 0.778 Transmembrane channel-like 5 79838 TMC5 A_23_P15101 -1.579 0.288 -1.983 -0.815 -2.636 -0.991 CDNA FLJ41771 fis, clone IMR322009807 A_32_P168388 0.302 0.175 0.405 -0.095 0.125 0.035 UDP glycosyltransferase 2 family, polypeptide7367 UGT2B17 B17 A_24_P17691 0.264 -1.346 -0.216 -0.605 -0.665 -0.496 ZNF814|LOC730051A_24_P490704 1.882 -0.413 0.634 -0.754 -0.31 -0.893 RGM domain family, member A 56963 RGMA A_24_P253454 -1.647 -1.746 2.435 1.475 1.074 1.255 TAFA4 protein 151647 FAM19A4 A_32_P71571 1.831 -0.049 3.37 2 1.49 1.15 KIAA1751 protein 85452 KIAA1751 A_24_P85258 2.924 -0.213 2.527 0.217 -0.373 0.277 Fibulin 1 2192 FBLN1 A_23_P211631 0.102 1.012 0.337 1.381 -0.14 0.472 Serum amyloid A4, constitutive 6291 SAA4 A_23_P87238 1.63 -0.11 -1.28 0.03 -0.33 -1.11 Vacuolar protein sorting protein 1857617 VPS18 A_24_P18802 0.649 -0.011 -0.49 -0.482 0.122 -0.755 Chemokine (C-C motif) ligand 2 6347 CCL2 A_23_P89431 -1.285 1.094 1.565 1.323 2.623 1.2 Annexin A8 244 ANXA8L2|ANXA8|ANXA8L1A_32_P105549 1.913 0.896 1.786 1.686 -2.104 2.796 Triggering receptor expressed on myeloid54210 TREM1cells 1 A_23_P19333 -0.428 2.37 2.474 1.011 1.699 0.449 KIAA1573 protein 57685 CACHD1 A_24_P943922 -0.002 0.041 2.546 1.359 0.867 1.189 Phosphoglucomutase 5 5239 PGM5P2|PGM5|LOC729468|LOC284964A_24_P254949 -0.232 -0.107 -0.347 0.473 -0.458 -0.528 A_32_P4882 -0.393 1.557 1.467 0.887 0.097 0.837 A_24_P148261 -0.958 2.683 1.583 1.943 0.063 1.033 KRT16|KRT14A_32_P76627 0.457 1.113 2.263 1.783 -3.337 1.393 C-terminal tensin-like 84951 TNS4 A_23_P207850 -0.558 1.27 2.83 1.3 -3.39 2.26 Period homolog 1 (Drosophila) 5187 PER1 A_24_P93916 -1.061 -1.185 -1.245 -0.515 -0.235 -1.455 Platelet-derived growth factor receptor-like5157 PDGFRL A_23_P60146 -0.386 0.855 0.695 1.525 0.655 0.435 Hypothetical gene supported by BX647608399959 A_32_P39944 0.227 1.234 1.534 1.784 -0.546 0.923 Hippocalcin-like 1 3241 HPCAL1 A_32_P151152 -0.967 -1.759 1.926 1.07 0.779 1.205 EGF-containing fibulin-like extracellular2202 matrix EFEMP1 protein 1 A_23_P501007 -0.812 1.622 0.915 1.165 1.569 0.979 A_24_P95070 -0.478 -1.707 -0.608 -1.228 -0.8 -1.78 A_32_P141938 0.124 -0.233 0.3 0.793 1.105 0.712 Homo sapiens, clone IMAGE:5194204, mRNA A_24_P740906 -0.311 -0.189 0.101 -0.089 0.111 -0.239 Desmocollin 3 1825 A_24_P344416 -2.117 0.866 4.651 1.978 -1.842 0.834 CDK4 A_23_P36392 0.056 0.338 0.258 -0.082 -0.022 0.078 IgH (thyroid peroxidase-specific Fab fragment) A_24_P315941 -0.004 0.176 1.656 1.656 -1.534 2.306 KIAA1922 protein 114819 CROCCL2 A_24_P392723 -1.596 -1.564 2.556 2.006 1.896 1.866 LOC728361|LOC644099A_24_P169213 0.005 0.045 -0.005 -0.205 0.135 -0.285 Hypothetical gene supported by BX647608399959 A_24_P904845 0.242 0.732 0.802 1.072 -1.028 0.672 Fanconi anemia, complementation group2176 CUTY|LILRA6|P2RX7 A_23_P71680 0.483 -0.549 0.031 1.171 1.271 0.941 A_24_P917668 -0.331 -0.149 0.531 -0.099 1.931 0.341 Likely ortholog of rat vacuole membrane81671 protein 1 A_32_P9753 -0.506 0.715 0.104 1.254 0.554 0.895 Dystonin 667 DST A_23_P59388 0.026 2.107 3.717 1.447 -5.023 1.437 Yippee-like 4 (Drosophila) 219539 YPEL4 A_23_P300220 -0.472 1.025 2.035 2.244 -0.415 1.905 Serine (or cysteine) proteinase inhibitor,5268 clade SERPINB5 B (ovalbumin), A_23_P208126 member 5 -0.178 1.312 1.902 0.622 -0.598 1.692 Microseminoprotein, beta- 4477 MSMB A_23_P75024 -0.033 -1.133 -0.2 -0.573 -0.808 -0.117 Hypothetical gene supported by BC008048440934 LOC440934 A_32_P219581 -1.233 1.653 3.263 0.663 -0.027 1.843 Similar to keratin 17 440421 LOC729682 A_24_P887857 -0.099 0.996 2.006 1.638 -4.119 1.853 FKSG43 gene 83957 A_23_P33927 -0.022 0.142 0.072 -0.128 0.252 -0.033 Laminin, alpha 3 3909 LAMA3 A_24_P687302 -0.2 1.429 2.239 0.759 -0.401 1.579 A_32_P202182 0.186 0.01 -0.141 1.46 1.55 1.11 Fibulin 1 2192 FBLN1 A_23_P433016 -0.417 0.653 0.269 1.294 0.309 0.361 ABI gene family, member 3 (NESH)25890 binding ABI3BP protein A_23_P218858 -0.908 1.006 0.486 1.654 0.75 0.509 Period homolog 2 (Drosophila) 8864 PER2 A_23_P209320 0.093 1.582 1.542 1.162 0.042 1.002 Cathepsin K (pycnodysostosis) 1513 CTSK A_23_P34744 -0.739 1.561 0.561 1.645 0.041 1.061 Histidine decarboxylase 3067 HDC A_23_P117662 0.4 0.702 -0.036 0.452 -0.381 0.341 Full-length cDNA clone CS0DI009YL06 of Placenta Cot A_32_P2961825-normalized of Homo-0.455 sapiens (human)0.285 0.408 1.745 2.144 1.282 Potassium large conductance calcium-activated10242 KCNMB2 channel, A_23_P158675 subfamily M, beta member-0.277 2 0.828 0.747 0.871 0.3 1.597 ATPase, H+ transporting, lysosomal245973 42kDa, ATP6V1C2 V1 subunit A_23_P250914C isoform 2 -0.078 -0.512 -0.712 -0.492 -0.452 -0.392 A_32_P190211 -0.128 -0.215 0.145 -0.506 -0.429 0.033 A_32_P158181 -1.108 0.004 0.964 1.004 -1.266 0.364 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase5209 PFKFB3 3A_24_P111096 1.855 0.97 2.44 1.3 1.44 0.98 Collagen, type XVII, alpha 1 1308 COL17A1 A_23_P501010 -0.512 2.117 3.147 1.657 -3.193 1.867 Alcohol dehydrogenase 1A (class I), alpha124 ADH1A polypeptide A_24_P291658 1.375 1.458 1.461 1.136 1.527 -0.192 Pancreatic lipase-related protein 2 5408 PNLIPRP2 A_23_P24083 -0.526 0.446 2.014 3.212 2.341 1.575 IGLV2-14 A_24_P169713 0.189 0.743 2.323 1.473 -1.288 2.663 Chromosome 14 open reading frame153514 81 A_24_P153558 -0.251 -0.35 -0.82 -0.8 -0.23 -1.31 Apolipoprotein H (beta-2-glycoprotein350 I) A_23_P38244 0.157 0.038 0.225 -0.31 0.144 0.188 Hypothetical protein DKFZp434F031881575 APOLD1 A_23_P48217 -0.17 2.206 2.336 0.616 0.896 -0.164 Chromosome 10 open reading frame282973 39 A_24_P332081 1.255 -0.327 2.784 1.593 1.123 1.003 A_32_P180610 -0.063 -0.441 -0.501 -0.501 -0.081 -0.571 A_32_P87582 1.102 0.744 1.314 1.554 1.874 1.854 Gremlin 2 homolog, cysteine knot superfamily64388 GREM2 (Xenopus A_24_P40626 laevis) -0.266 1.837 1.417 2.077 -0.283 0.657 Sperm associated antigen 9 9043 SPAG9 A_23_P356041 1.575 0.02 1.108 -0.564 -0.279 0.15 Keratin, hair, acidic, 4 3885 KRT34 A_23_P101054 -0.117 1.116 1.126 0.886 1.226 1.136 Elastase 2, neutrophil 1991 ELA2 A_23_P130961 0.189 -0.427 -0.768 -0.187 -0.078 -0.978 Low density lipoprotein receptor (familial3949 hypercholesterolemia) LDLR A_23_P208595 -0.588 0.181 0.002 -1.399 1.371 -0.189 A_32_P229447 0.353 0.246 0.891 0.222 0.521 -0.141 CD209 antigen-like 10332 CLEC4M A_24_P246196 -0.719 -0.197 -0.367 -0.267 -0.067 0.703 Brain and acute leukemia, cytoplasmic79870 BAALC A_23_P134663 -0.521 0.12 -1.18 0.301 0.521 -1.465 A disintegrin-like and metalloprotease9507 (reprolysin ADAMTS4 type) withA_23_P360754 thrombospondin type-0.63 1 motif, 4 1.788 2.674 -0.073 1.019 -0.072 SPARC-like 1 (mast9, hevin) 8404 SPARCL1 A_23_P113351 0.097 1.711 1.171 0.321 1.051 0.441 Promyelocytic leukemia 5371 PML A_23_P334664 -0.298 -0.535 -0.795 -0.545 -0.355 -0.685 Early growth response 2 (Krox-20 homolog,1959 EGR2 Drosophila) A_23_P46936 -1.454 1.289 2.449 0.798 -0.671 1.039 Nodal homolog (mouse) 4838 NODAL A_23_P127322 -0.033 -0.305 -0.465 -0.205 -0.115 -0.145 A_24_P921546 -0.001 -0.001 -0.391 0.4 1.579 0.04 GUF1 A_23_P129258 1.192 0.398 0.568 0.568 0.638 0.568 Lumican 4060 LUM A_23_P99063 -0.033 1.401 0.158 0.795 -0.697 1.167 Carcinoembryonic antigen-related cell4680 adhesion CEACAM6 molecule A_23_P218442 6 (non-specific cross reacting0.455 antigen)-0.757 -0.647 -1.027 -1.047 -0.808 A_24_P375510 -0.178 0.308 0.158 -0.332 0.348 -0.002 Hypothetical protein LOC284454 284454 A_24_P734060 -0.096 0.525 0.909 1.174 1.324 0.278 Testes development-related NYD-SP1884691 FAM137A A_23_P134204 -0.71 0.112 0.102 0.012 0.232 1.412 PGPEP1 A_24_P557019 -1.228 -0.978 1.963 1.152 0.772 0.822 Tumor necrosis factor receptor superfamily,8771 TNFRSF6B member 6b, A_23_P218646 decoy -0.011 1.229 0.619 1.029 0.939 0.809 A_24_P290046 1.525 1.847 1.567 1.087 1.007 0.617 Sulfatase 1 23213 SULF1 A_23_P43164 -1.023 2.321 2.071 1.001 0.531 1.501 Zic family member 2 (odd-paired homolog,7546 ZIC2 Drosophila) A_32_P179148 -0.106 0.718 0.498 0.538 0.748 0.268 Gap junction protein, beta 5 (connexin2709 31.1) GJB5 A_23_P35293 1.034 1 1.26 0.22 0.08 2.5 A_32_P13991 0.997 0.952 0.662 0.452 -0.378 0.622 A_32_P172002 1.289 1.022 1.402 1.482 1.761 1.621 Toll-like receptor 2 7097 TLR2 A_23_P92499 0.078 1.438 1.368 1.177 0.277 1.648 Odd-skipped related 2 (Drosophila)116039 OSR2 A_23_P71570 -0.053 0.247 -0.186 1.255 1.517 -0.496 Solute carrier family 19 (thiamine transporter),10560 SLC19A2 member A_23_P1604662 -0.012 2.008 1.768 0.988 0.478 0.668 Transient receptor potential cation channel,7220 TRPC1 subfamily C,A_24_P28977 member 1 0.279 1.167 1.137 0.866 0.026 0.977 ODZ2 A_24_P299474 -0.762 0.079 1.469 0.729 -1.701 2.699 FLJ44216 protein 375484 LOC202181 A_24_P930169 0.677 -0.813 -0.813 -0.593 -0.533 0.017 Frizzled-related protein 2487 FRZB A_23_P10902 -0.937 1.938 1.887 0.847 -0.063 1.857 ATPase, Class I, type 8B, member57198 2 ATP8B2 A_32_P185229 -0.026 0.367 0.107 0.707 0.227 0.966 A_24_P710024 -0.012 -0.828 -1.178 -0.878 -0.608 -1.348 Zinc finger, BED domain containing79413 2 ZBED2 A_23_P113793 -0.449 0.204 -0.046 0.144 0.964 1.265 A_24_P323298 0.496 0.32 1.22 1.57 -1.03 2.3 Collagen, type XVII, alpha 1 1308 COL17A1 A_23_P52323 -0.466 1.01 1.89 0.67 -3.26 1.76 Deleted in malignant brain tumors 11755 DMBT1 A_23_P86599 -0.94 0.087 0.627 0.817 -0.063 0.807 Dicer1, Dcr-1 homolog (Drosophila)23405 DICER1 A_32_P199923 -0.76 -1.097 -0.607 0.004 -0.266 0.194 Sperm acrosome associated 1 81833 SPACA1 A_23_P30649 -0.29 -0.154 -0.174 -0.114 0.066 -0.204 Keratin 14 (epidermolysis bullosa simplex,3861 KRT14 Dowling-Meara, A_24_P265346 Koebner) 0.309 1.002 1.801 1.332 -3.978 1.002 A_23_P70069 1.555 0.01 0.57 0.31 0.14 0.44 TCDD-inducible poly(ADP-ribose) 25976polymerase TIPARP A_23_P143845 0.001 1.919 1.169 0.399 0.079 0.409 PPIL5 A_23_P102071 1.802 0.259 1.839 0.449 0.019 -0.081 A_32_P217901 -0.39 1.521 1.071 0.831 0.981 0.961 Hypothetical protein FLJ39963 349075 A_23_P74114 0.881 0.063 0.223 0.513 0.613 0.663 BMP-binding endothelial regulator168667 precursor BMPER protein A_23_P31287 0.166 -0.004 -1.564 -0.674 0.276 -0.454 Immunoglobulin J polypeptide, linker3512 protein IGJ for immunoglobulinA_23_P167168 alpha and mu polypeptides1.627 0.85 2.22 1.78 -4.73 2.69 06-1117A (XP)06-1291 06-1381A (XP)06-1413A-244k07-0021A-244k07-0158A-244k07-0342A-244k07-0475A (XP)UNC00-0164A-244KUNC02-0575A-244KUNC03-0477A-244KUNC04-0115A-244KUNC04-0547A-244K -3.703 3.524 0.412 3.652 1.562 4.932 2.772 1.046 3.862 3.252 3.882 0.732 3.112 -2.215 4.275 0.86 2.175 1.845 1.525 2.975 -1.045 3.035 3.125 5.555 -0.105 4.355 -1.744 -1.813 -0.7 -1.716 -1.466 -2.116 -1.986 -0.379 -1.026 -1.576 -1.726 -1.806 -1.146 -1.571 1.03 -2.234 -1.841 -1.071 -2.122 -1.202 -1.202 -2.471 -1.202 -1.632 -2.071 -1.402 -0.151 2.856 0.806 0.835 2.066 1.553 0.792 0.553 1.076 1.018 4.577 2.001 2.419 0.478 -0.385 0.097 -0.358 -1.298 -0.408 -0.498 0.248 -1.258 -0.478 -0.278 -0.008 0.262 -1.019 1.55 1.414 2.691 2.191 2.29 2.41 0.559 2.031 1.981 4.311 0.728 2.441 -0.376 0.845 0.745 2.629 2.191 2.714 4.132 0.919 2.407 1.752 2.381 0.435 2.003 0.071 -0.526 -0.455 -0.675 -1.045 -0.815 -0.705 -0.02 -0.985 -0.645 -0.915 -0.235 0.255 0.574 2.369 1.946 1.689 2.079 1.015 1.51 1.412 1.63 0.659 2.499 0.809 1.05 -1.021 2.651 1.723 3.555 1.975 4.215 3.555 0.898 3.285 3.025 3.635 -0.175 3.015 0.839 -0.7 -0.413 -2.12 1.16 -2.54 -2.92 -2.282 -2.78 -2.25 -1.68 0.01 -1.55 3.694 1.101 0.197 1.17 2.821 3.45 1.7 4.055 0.41 4.02 2.55 3.826 2.652 -1.038 0.774 1.135 2.335 3.165 1.315 -0.305 -0.054 1.345 -0.335 1.825 0.245 0.375 4.44 0.678 0.323 0.651 1.619 3.073 1.645 5.227 0.23 4.558 3.766 3.968 3.764 0.222 -0.772 -0.031 -0.082 -0.322 -0.681 0.118 0.096 -0.332 -1.022 -0.742 -0.512 -0.102 0.085 -0.298 -0.007 0.19 -0.16 0.16 -0.05 -0.406 -0.28 -0.03 -0.16 -0.25 0.51 -1.643 -1.754 -0.566 -0.809 -1.298 -2.318 -1.894 -0.617 -0.964 -1.638 -1.105 -1.203 -0.429 0.185 -0.099 -0.314 -0.21 -0.3 -0.16 -0.21 -0.143 -0.571 0.59 -0.16 0.17 0.889 3.133 0.82 0.452 1.451 2.091 3.541 2.211 3.294 -0.609 2.313 1.025 1.269 0.746 -1.487 -0.84 -0.374 -0.939 -1.382 -1.414 -1.183 -0.65 -0.443 -0.881 0.4 -1 -0.73 -2.588 0.224 -0.043 1.343 1.927 1.283 -0.11 -2.139 -0.174 0.681 1.619 -1.065 -0.551 1.266 0.77 0.858 1.392 1.472 2.572 1.442 2.283 -1.288 2.152 1.342 0.962 0.952 -0.538 1.114 0.31 1.36 1.78 1.4 1.52 -0.891 1.96 2.4 2.41 1.14 1.74 0.389 -0.132 -0.377 -0.644 -0.945 -0.465 -0.415 0.288 -0.375 -0.073 -1.041 0.066 -0.245 -1.612 3.281 -0.941 0.282 1.804 -1.309 -0.621 -2.563 0.007 1.927 3.777 3.313 2.651 -0.375 -0.318 0.046 -0.092 -0.272 -0.142 0.028 0.344 -0.412 -0.532 -0.822 -0.102 0.448 -1.194 -1.131 -0.782 -0.394 -0.444 -0.204 -0.234 -0.65 -0.514 -0.054 -0.634 -0.164 -0.114 -0.449 -0.194 -0.462 0.056 -0.553 0.067 0.406 -0.083 -0.194 0.434 0.416 0.294 0.987 -1.372 0.552 -1.229 -1.477 -0.987 -2.527 -1.607 -2.509 -2.147 -1.367 -0.657 -0.927 -0.547 -2.601 -1.009 -0.272 -0.699 -0.819 -1.729 -1.353 -0.306 -1.439 -0.495 -0.859 -0.919 -0.479 -1.37 1.235 0.86 1.75 1.86 1.35 1.7 0.32 1.43 0.85 2.95 0.5 1.29 -0.773 1.888 0.386 1.198 1.838 0.648 0.488 -1.19 1.369 0.838 3.152 1.009 1.468 -0.688 2.364 -0.163 3.521 1.362 4.553 2.07 0.616 3.419 2.385 3.43 0.031 3.219 -2.2 1.177 1.359 2.407 1.057 2.277 1.617 1.766 2.497 1.278 2.317 0.498 2.067 -1.815 0.002 -1.215 0.544 -0.155 -0.375 1.174 -0.002 -1.345 -0.315 -0.776 -0.815 -0.006 -1.116 -1.032 -0.716 -1.021 -1.375 -2.108 -1.524 0.229 -1.253 -0.477 0.12 0.657 -0.43 -1.343 2.426 1.669 2.348 2.428 1.288 1.778 0.334 2.168 -0.162 2.618 -0.202 2.198 1.567 0.729 0.757 1.401 1.491 0.891 -0.119 0.41 0.491 0.901 2.211 -0.229 0.111 -1.103 -1.399 -0.169 -0.576 -1.357 -1.085 -1.317 -0.239 -0.569 -1.056 -0.645 -1.47 -0.368 1.232 1.822 1.682 1.83 1.83 0.85 1.62 1.629 1.03 -0.26 2.03 1.63 1.07 0.278 0.38 -2.005 -2.023 -1.723 -1.663 -1.443 -1.318 -1.743 -0.823 -1.163 -1.493 -1.023 -3.202 1.514 0.463 1.796 1.536 2.475 0.896 0.339 1.696 0.856 1.486 -1.488 0.976 -3.572 1.164 1.035 2.239 0.999 2.399 1.409 1.478 1.219 1.039 1.959 0.589 2.029 -1.537 0.2 0.404 3.308 0.738 3.088 3.348 0.555 1.578 2.528 2.478 -1.242 2.288 -2.204 1.257 0.754 2.156 1.086 2.546 1.406 1.487 1.206 0.116 0.164 0.436 1.536 -0.863 1.475 -0.283 2.927 0.948 4.283 1.535 0.45 2.773 1.765 3.134 0.252 3.196 -3.136 1.444 -1.328 -0.228 -1.279 -0.998 -0.038 0.695 -0.498 -0.068 0.202 -0.259 0.901 0.111 0.056 -0.267 -0.085 -0.185 0.135 -0.005 0.167 -0.825 -0.205 -0.555 -0.875 0.075 0.08 0.263 -2.009 -2.074 -1.804 -1.614 -1.454 -1.283 -1.844 -0.994 -1.304 -1.664 -1.304 0.374 -0.31 -0.25 -0.085 -0.469 0.006 0.006 0.083 0.166 0.968 0.085 -0.366 0.396 -2.314 0.678 0.737 1.517 0.877 1.987 2.167 1.252 2.556 1.117 1.357 0.157 1.347 -3.206 2.362 -1.151 1.557 0.622 0.651 4.432 -0.183 0.861 1.694 3.987 -0.406 2.276 0.62 1.02 0.177 1.677 1.157 1.877 1.347 0.915 0.157 0.627 0.667 0.887 1.877 0.771 -0.25 -0.373 -1.842 -0.762 -2.182 -2.802 -1.246 -2.562 -3.732 -1.512 -0.772 -2.432 -0.159 1.016 1.616 1.04 2.199 1.08 0.949 0.03 1.37 -0.811 1.109 0.34 0.529 -2.147 2.461 0.173 1.044 0.865 0.023 1.795 0.506 2.384 0.309 2.775 -0.42 2.312 2.686 1.324 0.414 1.358 1.645 2.856 1.842 2.728 -0.139 2.636 1.964 1.871 2.017 2.549 0.142 -0.6 0.512 1.392 2.992 1.692 2.729 0.232 3.872 2.632 3.382 3.402 0.156 1.713 1.631 1.402 1.832 0.712 1.082 1.595 1.602 0.011 1.822 0.669 1.002 -5.635 0.865 -0.18 2.157 0.776 2.896 1.976 0.954 3.056 2.676 1.236 0.156 1.577 -1.243 1.408 0.866 1.797 2.447 1.407 1.507 -0.156 1.957 0.577 2.357 0.367 1.527 -1.399 1.1 1.242 1.991 1.541 1.84 1.541 0.609 2.59 1.291 1.86 -0.429 1.3 0.474 1.224 1.208 1.599 1.669 0.129 2.369 0.694 -0.581 1.18 3.13 1.507 1.369 -0.872 0.132 1.647 0.776 1.067 0.46 2.327 -1.962 0.504 0.001 1.747 0.277 0.587 3.235 1.165 1.309 1.649 2.242 3.53 2.384 4.19 -0.705 2.474 2.236 1.55 1.979 0.178 -0.248 -0.4 -0.412 -2.832 0.378 -1.422 0.423 -0.382 -0.672 -0.542 1.018 -1.042 0.369 1.794 1.609 1.178 2.428 0.468 0.968 0.392 0.358 -0.312 1.288 0.298 0.798 -0.101 0.225 0.247 0.846 1.166 1.416 0.816 1.37 2.126 0.626 2.016 0.156 0.646 -1.981 -1.114 0.248 -0.697 -1.574 -1.336 -1.516 -0.868 -0.839 0.379 0.501 -0.101 -0.3 -0.635 0.828 0.54 0.521 1.309 1.243 0.594 -1.12 0.743 -0.1 4.066 0.45 1.581 0.257 1.324 0.142 0.227 1.547 1.727 0.625 -0.343 0.627 0.277 0.497 -0.663 0.023 0.302 0.381 1.256 1.002 0.53 1.242 0.932 0.005 0.235 0.482 0.672 0.242 1.592 -1.512 -0.636 -2.457 -0.487 -0.497 -2.417 -1.667 -3.194 -1.047 -1.667 -1.227 -1.497 -2.007 0.873 -0.009 0.744 -2.196 0.009 -2.279 -2.712 -3.109 -1.803 -1.629 -1.187 -0.154 -1.787 3.145 1.059 0.524 1.473 2.113 3.413 2.083 2.719 0.153 1.408 0.881 1.952 3.59 0.361 -0.359 -0.361 -0.446 -0.206 -0.506 -0.496 -0.593 -0.756 0.244 -0.186 -0.686 0.164 0.204 1.163 0.553 -0.026 1.144 0.104 0.534 -0.058 -0.346 -1.086 2.574 1.514 0.824 0.224 0.999 1.268 1.204 1.535 0.525 0.965 0.724 1.385 0.065 1.704 0.471 0.394 -0.046 0.559 0.197 1.22 1.16 0.98 1.32 0.237 1.24 1.78 1.592 1.072 0.834 2.904 0.629 0.246 1.077 1.597 2.951 1.89 3.427 -0.566 2.213 2.015 2.1 1.675 -0.62 1.304 1.363 3.087 1.497 3.237 2.837 0.361 2.587 2.247 3.297 -0.893 2.697 -1.713 1.708 -0.299 0.548 1.388 -0.392 0.698 -1.567 0.058 -0.082 2.268 1.368 1.588 -2.429 -0.57 0.064 -0.752 -2.306 -0.9 -1.595 -2.461 2.748 1.078 0.439 -0.264 -0.159 -0.14 0.05 -0.186 0.005 0.065 -0.085 0.065 0.318 -0.915 -0.295 -0.385 -0.425 0.185 0.284 -0.092 -0.597 -0.776 -1.166 -1.656 -1.016 0.056 -0.426 -1.986 -2.325 0.384 -1.076 3.572 -0.141 -0.164 -0.179 0.803 2.413 0.006 3.686 0.82 4.557 3.763 3.173 3.872 2.404 1.224 0.496 1.455 1.566 2.945 2.035 2.725 -0.915 2.693 1.464 0.999 1.411 0.039 0.628 0.388 1.28 2.2 3.55 2.43 1.281 -0.73 1.95 1.66 2.91 2.18 2.723 0.35 0.032 0.757 1.627 2.697 1.577 3.002 -0.673 2.741 2.037 1.807 1.174 -0.151 0.829 0.849 1.681 1.917 1.236 0.731 0.618 -0.106 0.7 1.495 -0.136 0.854 2.05 -1.1 -1.52 -2.01 -2.25 -3.45 -2.97 -1.59 -3.76 -0.51 -3.18 1.27 -1.49 -0.966 -0.327 0.162 -0.08 -0.798 -0.525 -0.462 -0.099 -0.547 -0.517 -0.335 -0.309 -0.226 -1.394 1.554 -0.525 -0.11 1.942 -0.015 0.223 -1.866 0.048 -0.027 3.091 0.597 1.614 -2.201 1.329 0.179 3.086 0.266 3.116 3.356 0.409 1.313 2.766 2.176 -0.864 2.016 -0.559 2.067 -0.116 0.667 2.38 0.292 0.411 -1.541 0.022 0.419 2.488 0.558 1.678 2.227 0.587 0.638 1.238 1.433 2.922 1.839 2.409 -0.563 3.205 1.904 1.048 1.796 -0.837 -0.995 0.396 -0.228 -0.407 -0.067 -0.167 0.083 -0.377 -0.837 -0.508 -1.078 -0.077 -1.051 1.502 0.208 1.587 0.787 1.157 1.148 0.109 1.345 1.007 2.837 0.688 1.537 -3.085 0.47 1.396 3.173 1.123 2.643 1.803 -0.4 1.933 1.203 1.993 -0.727 1.883 -3.569 0.784 0.444 2.083 0.723 2.223 1.402 1.384 1.513 1.083 1.793 -0.298 1.393 -3.768 0.512 0.396 1.98 0.5 2.7 2.02 0.791 2.37 2.44 1.65 0.77 1.86 0.473 -0.518 -1.078 -1.265 -0.695 -2.175 -1.475 -0.192 -1.565 -1.315 -0.775 -0.225 -1.025 0.065 0.918 0.807 0.975 1.611 0.515 0.335 0 0.575 -0.085 0.905 0.635 1.155 -1.4 -0.331 0.985 1.174 0.804 1.974 0.954 0.585 2.463 1.364 1.634 0.504 0.694 2.974 1.426 0.66 1.423 1.497 2.682 1.95 3.276 -1.005 2.167 1.866 1.14 1.558 -0.694 0.375 0.161 0.573 1.872 0.118 0.185 -0.907 0.617 -0.462 0.837 -0.281 0.545 0.443 -0.037 0.338 -2.182 0.044 -1.964 -2.328 -2.69 -1.139 -1.834 -0.964 -1.369 -1.323 2.534 0.19 1.068 1.483 -0.296 2.005 1.613 2.881 -0.819 1.978 1.173 0.744 2.261 0.058 -0.218 -0.376 -0.219 -0.139 -0.049 -0.239 -0.383 -0.119 0.391 0.091 0.411 0.351 -2.404 3.165 -0.6 2.624 0.684 1.494 0.89 0.598 2.754 2.284 1.294 0.444 0.844 0.453 0.032 -0.167 0.158 0.058 0.088 0.198 0.176 -0.392 -0.392 -0.74 -0.142 0.338 -1.461 0.394 0.01 2.656 2.526 1.896 1.876 1.569 0.256 0.426 0.006 0.846 1.446 2.139 1.573 0.949 1.646 1.946 3.226 2.506 2.954 -1.344 2.18 0.706 1.487 0.455 0.094 -0.151 -0.164 -0.175 -0.145 -0.035 -0.185 0.091 -0.775 -0.435 -0.715 -0.515 0.085 -0.578 -0.4 1.096 1.032 0.812 1.482 0.672 0.703 2.222 1.162 1.462 0.482 0.962 3.053 -0.503 0.989 1.761 -0.199 2.821 2.021 2.411 -0.319 3.451 2.121 2.584 3.024 -0.848 1.891 0.447 0.701 0.881 -0.009 0.461 0.105 1.751 -0.049 2.241 -0.349 0.601 -1.644 0.65 0.578 0.455 1.335 0.485 -0.396 -0.496 2.985 1.406 2.055 1.085 0.265 -4.754 0.973 0.474 2.197 0.197 2.277 0.957 1.916 2.947 1.807 1.467 0.581 1.647 -1.839 0.943 0.764 1.965 1.494 1.865 0.455 0.803 2.255 1.165 1.125 0.414 1.395 -2.016 1.196 -0.081 1.852 0.782 2.402 1.972 0.89 2.402 2.112 1.872 0.582 1.552 0.042 -0.715 -0.538 -1.022 -0.572 -0.777 -0.823 0.041 0.826 -2.352 -2.503 -0.187 -1.132 -0.818 2.471 0.027 0.903 0.633 1.403 2.173 -0.298 1.913 1.113 1.143 -0.757 1.253 -3.218 0.922 0.871 2.186 1.228 2.173 1.188 1.463 3.035 1.445 1.707 0.597 1.962 0.088 -0.104 -0.278 -0.178 -0.128 -0.148 -0.108 -0.208 -0.418 -0.038 -0.628 -0.588 -0.078 -0.864 0.975 0.753 1.369 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-0.388 0.587 -0.412 0.154 -0.048 0.205 0.16 -0.102 0.264 0.395 -0.148 -0.58 -0.422 -0.375 -0.773 -0.267 0.204 -0.51 -0.921 -0.018 0.032 -0.186 -1.092 -0.24 0.602 -1.789 -0.796 -2.266 -0.404 -2.915 -1.602 -4.056 0.125 0.719 1.977 0.029 -0.063 1.404 1.578 4.571 3.719 3.634 2.647 -0.289 -0.647 0.914 -1.03 -0.366 -1.384 -0.895 -0.041 -0.91 -0.226 -0.786 -0.387 -0.129 -0.845 -0.792 -0.768 -0.914 -0.564 -0.481 -1.111 -1.14 -0.955 0.688 1.212 -1.06 -0.013 0.895 0.944 0.982 1.407 0.599 0.145 -0.106 0.142 -0.831 -1.583 -0.01 -0.385 0.647 0.93 -1.015 -0.869 -0.642 -1.018 0.272 1.212 -1.309 0.195 0.543 -1.439 -1.661 -1.33 -1.051 -0.573 -0.812 -0.185 -0.394 0.425 0.309 -2.386 -1.802 -3.669 0.008 -2.069 -0.099 -5.265 -0.738 -0.877 -0.745 -0.129 -1.107 0.073 -1.476 0.742 -1.48 -1.345 -1.901 -0.731 -0.742 0.19 -0.731 -0.651 0.159 0.548 2.412 0.944 0.11 0.452 -0.036 -0.234 1.012 -0.221 -0.349 1.068 1.182 4.224 3.303 3.175 2.344 -0.111 -0.197 -1.204 -0.038 -1.79 -1.482 -3.184 -0.987 -2.859 -1.123 -3.978 -0.487 0.417 0.078 -0.991 -0.317 -0.504 -0.45 0.13 -0.667 -0.907 -0.903 -0.713 0.029 -0.508 -0.752 0.954 0.269 -0.278 -0.639 -0.098 0.635 0.089 -1.726 1.325 -1.158 -2.78 -1.538 -0.952 -0.484 1.308 1.851 0.146 0.301 -0.096 -0.32 4.644 -0.213 -0.772 -0.684 -0.889 0.015 -1.174 -1.748 -0.233 -0.563 1.449 0.114 -0.681 -0.038 -0.258 -0.338 0.517 0.446 0.024 0.077 0.308 0.409 -0.557 0.592 1.1 0.209 0.156 0.013 1.494 0.539 1.064 1.173 1.38 -1.688 -0.204 -1.391 -0.602 -3.656 -1.555 -1.412 -0.079 -3.742 Functional Group 1 Median: 3.6113051376203477E-10 Geo: 2.2873101712234948E-10 1308, 9547, 3553, 23213, 6291, 11117, 81851, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 158326, 7057, 3909, 6347, 3512, 4053, 3598, 25975, 1991, 168667, 4060, 5408, 2202, 1490, 81575, 667, 3491, 2919, 6279, 2487, 3624, 3918, 350, 2192, 4838, 1825, 7367, 8434, 7097, 54210, 2152, 25890, 5268, 3949, 5743, 25960, 57685, 4680, 81833, 56963, 8771, 84951, 942, 5100, 1513, 5157, 10560, 10332, 10242, 3043, 79586, 2191, 2357, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0005576~extracellular region 39 29.32% 1.17E-14 1308, 9547, 3553, 23213, 6291, 11117, 81851, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 158326, 7057, 3909, 6347, 3512, 4053, 3598, 25975, 1991, 168667, 4060, 5408, 2202, 1490, 81575, 667, 3491, 2919, 6279, 2487, 3624, 3918, 350, 2192, 4838, SP_PIR_KEYWORDS signal 53 39.85% 3.22E-11 1825, 23213, 7367, 8434, 7097, 1440, 8404, 5340, 54210, 7057, 2152, 3909, 25890, 25975, 168667, 4060, 1991, 5408, 3491, 5268, 3918, 3949, 2192, 5743, 25960, 57685, 9547, 4680, 11117, 6291, 1755, 7980, 4969, 64388, 158326, 81833, 6347, 3598, 4053, 56963, 8771, 84951, 2202, 1490, 942, 2919, 5100, 1513, 5157, 2487, 3624, 350, 4838, GOTERM_CC_ALL GO:0044421~extracellular region part 28 21.05% 6.18E-11 1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, SP_PIR_KEYWORDS glycoprotein 58 43.61% 2.13E-10 1308, 10560, 1825, 10332, 23213, 7367, 8434, 7097, 1440, 8404, 5340, 54210, 10242, 7057, 2152, 3909, 3512, 25975, 168667, 4060, 1991, 5408, 5268, 3918, 3949, 2192, 3043, 5743, 25960, 57685, 4680, 11117, 6291, 1755, 7980, 4969, 64388, 158326, 81833, 6347, 79586, 4053, 3598, 56963, 8771, 2191, 2202, 1490, 667, 2357, 942, 5100, 5157, 1513, 2487, 3624, 350, 4838, SP_PIR_KEYWORDS Secreted 35 26.32% 5.09E-10 1308, 9547, 10332, 3553, 11117, 6291, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 54210, 158326, 3909, 6347, 4053, 25975, 8771, 168667, 4060, 2202, 5408, 1490, 3491, 5268, 2919, 5157, 2487, 3624, 3918, 350, 2192, 4838, UP_SEQ_FEATURE signal peptide 46 34.59% 1.15E-09 4680, 1825, 23213, 6291, 7367, 11117, 8434, 1755, 7980, 4969, 7097, 1440, 8404, 5340, 64388, 54210, 158326, 2152, 7057, 3909, 25890, 6347, 4053, 3598, 56963, 8771, 1991, 4060, 168667, 5408, 2202, 1490, 942, 3491, 2919, 5100, 1513, 2487, 3624, 3949, 3918, 350, 5743, 2192, 25960, 4838, UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 48 36.09% 1.75E-08 1308, 10560, 1825, 4680, 23213, 7367, 11117, 8434, 1755, 7980, 4969, 7097, 8404, 5340, 64388, 54210, 10242, 158326, 2152, 7057, 3909, 6347, 79586, 3512, 4053, 3598, 56963, 8771, 1991, 168667, 2191, 5408, 2202, 1490, 667, 2357, 942, 5100, 1513, 2487, 3624, 3949, 3918, 350, 5743, 2192, 25960, 4838, UP_SEQ_FEATURE disulfide bond 38 28.57% 1.47E-07 4680, 11117, 8434, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 54210, 158326, 7057, 2152, 3909, 6347, 3512, 4053, 3598, 8771, 4060, 1991, 2202, 5408, 1490, 2357, 942, 3491, 2919, 1513, 2487, 3624, 3949, 3918, 350, 5743, 2192, 4838,

Functional Group 2 Median: 8.732577920725165E-7 Geo: 2.3605922193373615E-6 1308, 10560, 116039, 3553, 8434, 7097, 1440, 5340, 10242, 5896, 7057, 2152, 3909, 5371, 25975, 4060, 1991, 5408, 10481, 3491, 8013, 3918, 3949, 3043, 5743, 5307, 2572, 2709, 10361, 7980, 3853, 158326, 1959, 6347, 56963, 23405, 8626, 2202, 1490, 81575, 942, 2070, 244, 2919, 3899, 5100, 2487, 2167, 3624, 3853, 3854, 3861, 350, 4838, 3885, 1755, 23213, 8771, 84951, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0032501~multicellular organismal process 55 41.35% 2.87E-09 1308, 10560, 116039, 3553, 8434, 7097, 1440, 5340, 10242, 5896, 7057, 2152, 3909, 5371, 25975, 4060, 1991, 5408, 10481, 3491, 8013, 3918, 3949, 3043, 5743, 5307, 2572, 2709, 10361, 7980, 3853, 158326, 1959, 6347, 56963, 23405, 8626, 2202, 1490, 81575, 942, 2070, 244, 2919, 3899, 5100, 2487, 2167, 3624, 3853, 3854, 3861, 350, 4838, 3885, GOTERM_BP_ALL GO:0048513~organ development 32 24.06% 8.32E-09 1308, 116039, 3553, 8434, 2709, 1440, 5340, 3853, 5896, 7057, 3909, 1959, 6347, 5371, 8626, 23405, 1490, 81575, 942, 10481, 3491, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 4838, 3885, 5307, GOTERM_BP_ALL GO:0007275~multicellular organismal development 42 31.58% 9.04E-08 1308, 116039, 3553, 8434, 2709, 10361, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, GOTERM_BP_ALL GO:0048856~anatomical structure development 39 29.32% 3.59E-07 1308, 116039, 3553, 8434, 2709, 1755, 1440, 5340, 3853, 5896, 10242, 7057, 3909, 1959, 6347, 5371, 56963, 8626, 23405, 81575, 1490, 942, 3491, 10481, 2070, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, GOTERM_BP_ALL GO:0048731~system development 34 25.56% 8.73E-07 1308, 116039, 3553, 8434, 2709, 1440, 5340, 3853, 5896, 7057, 3909, 1959, 6347, 5371, 56963, 8626, 23405, 1490, 81575, 942, 10481, 3491, 2919, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 4838, 3885, 5307, GOTERM_BP_ALL GO:0032502~developmental process 47 35.34% 7.03E-06 1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, GOTERM_BP_ALL GO:0009653~anatomical structure morphogenesis 22 16.54% 1.52E-04 6347, 5371, 56963, 116039, 3553, 8626, 23405, 1755, 81575, 1490, 3491, 2070, 5100, 5340, 8013, 3624, 3861, 3043, 4838, 10242, 7057, 5307, GOTERM_BP_ALL GO:0048869~cellular developmental process 27 20.30% 0.001771717 3553, 23213, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 3909, 1959, 6347, 5371, 25975, 23405, 8626, 8771, 84951, 1490, 81575, 942, 2487, 3624, 3853, 3861, 5743, 4838, GOTERM_BP_ALL GO:0030154~cell differentiation 27 20.30% 0.001771717 3553, 23213, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 3909, 1959, 6347, 5371, 25975, 23405, 8626, 8771, 84951, 1490, 81575, 942, 2487, 3624, 3853, 3861, 5743, 4838,

Functional Group 3 Median: 7.933954114206458E-6 Geo: 1.0274488702892272E-5 1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0044421~extracellular region part 28 21.05% 6.18E-11 1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, GOTERM_CC_ALL GO:0005578~proteinaceous extracellular matrix 14 10.53% 1.77E-06 1308, 4053, 11117, 4060, 2202, 1490, 667, 7980, 4969, 8404, 3918, 2192, 158326, 3909, GOTERM_CC_ALL GO:0031012~extracellular matrix 14 10.53% 2.14E-06 1308, 4053, 11117, 4060, 2202, 1490, 667, 7980, 4969, 8404, 3918, 2192, 158326, 3909, SP_PIR_KEYWORDS extracellular matrix 11 8.27% 7.93E-06 8404, 1308, 11117, 4060, 3918, 2192, 667, 1490, 158326, 3909, 4969, GOTERM_CC_ALL GO:0044420~extracellular matrix part 6 4.51% 0.001533988 4060, 3918, 2192, 667, 158326, 3909, SP_PIR_KEYWORDS basement membrane 4 3.01% 0.00181987 3918, 667, 158326, 3909, GOTERM_CC_ALL GO:0005604~basement membrane 5 3.76% 0.002326251 3918, 2192, 667, 158326, 3909,

Functional Group 4 Median: 0.002867592989769789 Geo: 5.161474103952231E-4 1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, 6291, 1991, 5187, 2357, 3491, 10481, 7097, 244, 2167, 350, 5743, 2152, 1959, 5371, 8626, 3658, 29974, 3949, 3043, 10242, 5408, 1755, 10332, 3620, 54210, 5896, 2176, 3512, 23405, 942, 3159, 8771, 84951, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0044421~extracellular region part 28 21.05% 6.18E-11 1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, GOTERM_BP_ALL GO:0009605~response to external stimulus 23 17.29% 4.90E-09 6347, 9547, 3553, 6291, 1991, 5187, 1490, 2357, 7980, 3491, 10481, 7097, 244, 2919, 5340, 6279, 2167, 3624, 350, 5743, 7057, 2152, 1959, GOTERM_BP_ALL GO:0009611~response to wounding 19 14.29% 8.01E-09 6347, 9547, 3553, 6291, 1991, 1490, 2357, 7980, 10481, 7097, 244, 2919, 5340, 6279, 2167, 350, 5743, 7057, 2152, GOTERM_CC_ALL GO:0005615~extracellular space 18 13.53% 5.40E-07 6347, 9547, 4053, 3598, 3553, 25975, 23213, 1490, 667, 1440, 2919, 5340, 6279, 3624, 64388, 2192, 4838, 7057, GOTERM_BP_ALL GO:0065008~regulation of biological quality 22 16.54% 3.50E-06 6347, 5371, 3553, 8626, 1991, 1490, 7980, 3491, 3658, 244, 5340, 2167, 3624, 29974, 3949, 350, 5743, 3043, 10242, 7057, 2152, 1959, GOTERM_BP_ALL GO:0006952~defense response 17 12.78% 6.55E-06 6347, 9547, 3553, 6291, 1991, 5408, 1755, 2357, 7097, 1440, 2919, 6279, 2167, 3624, 350, 5743, 7057, GOTERM_BP_ALL GO:0050896~response to stimulus 37 27.82% 1.46E-05 9547, 10332, 3553, 6291, 1755, 5187, 3620, 7980, 7097, 1440, 5340, 54210, 5896, 10242, 7057, 2152, 1959, 6347, 2176, 3512, 5371, 8626, 23405, 1991, 5408, 1490, 2357, 942, 3491, 10481, 244, 2919, 6279, 2167, 3624, 350, 5743, GOTERM_BP_ALL GO:0006954~inflammatory response 12 9.02% 2.87E-05 6347, 2919, 6279, 9547, 3553, 2167, 6291, 1991, 5743, 2357, 7057, 7097, GOTERM_BP_ALL GO:0006950~response to stress 21 15.79% 2.29E-04 6347, 2176, 9547, 5371, 3553, 6291, 1991, 1490, 2357, 7980, 10481, 7097, 244, 2919, 5340, 6279, 2167, 350, 5743, 7057, 2152, SP_PIR_KEYWORDS cytokine 8 6.02% 4.35E-04 1440, 6347, 2919, 6279, 9547, 3553, 64388, 4838, GOTERM_BP_ALL GO:0006935~chemotaxis 7 5.26% 0.001178295 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_BP_ALL GO:0042330~taxis 7 5.26% 0.001178295 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_MF_ALL GO:0008083~growth factor activity 7 5.26% 0.002767429 1440, 2919, 3553, 3624, 4838, 1490, 4969, GOTERM_MF_ALL GO:0005125~cytokine activity 8 6.02% 0.002867593 1440, 6347, 2919, 9547, 3553, 3624, 64388, 4838, GOTERM_BP_ALL GO:0007626~locomotory behavior 7 5.26% 0.004458995 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_BP_ALL GO:0042221~response to chemical stimulus 12 9.02% 0.006065844 6347, 2919, 9547, 3553, 23405, 1991, 5743, 10242, 2357, 3491, 1959, 7097, GOTERM_MF_ALL GO:0005102~receptor binding 14 10.53% 0.007022245 6347, 9547, 3553, 25975, 1490, 667, 4969, 1440, 2919, 3624, 64388, 4838, 3159, 3909, GOTERM_BP_ALL GO:0007610~behavior 8 6.02% 0.01489844 6347, 2919, 9547, 3553, 1991, 2357, 3491, 1959, SP_PIR_KEYWORDS inflammatory response 4 3.01% 0.015532823 6347, 2919, 3553, 7097, SP_PIR_KEYWORDS growth factor 5 3.76% 0.01826673 1440, 2919, 3624, 4838, 4969, KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 7 5.26% 0.03729405 1440, 6347, 2919, 9547, 3553, 3624, 8771, GOTERM_MF_ALL GO:0008009~chemokine activity 3 2.26% 0.061363286 6347, 2919, 9547, GOTERM_MF_ALL GO:0042379~chemokine receptor binding 3 2.26% 0.06378748 6347, 2919, 9547, SP_PIR_KEYWORDS chemotaxis 3 2.26% 0.105018738 6347, 2357, 3491, GOTERM_MF_ALL GO:0001664~G-protein-coupled receptor binding 3 2.26% 0.126951521 6347, 2919, 9547, GOTERM_BP_ALL GO:0007243~protein kinase cascade 3 2.26% 0.851750918 6347, 3553, 2357, GOTERM_BP_ALL GO:0007242~intracellular signaling cascade 8 6.02% 0.955904503 6347, 2919, 3553, 10332, 84951, 54210, 1490, 2357,

Functional Group 5 Median: 3.290065321161615E-4 Geo: 7.368687476461571E-4 5340, 5371, 8013, 3553, 23405, 1490, 81575, 7057, 3491, 8434, 6347, 116039, 8626, 4838, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0048646~anatomical structure formation 9 6.77% 1.15E-04 5340, 5371, 8013, 3553, 23405, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0001568~blood vessel development 9 6.77% 1.71E-04 5340, 5371, 3553, 23405, 8434, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0001525~angiogenesis 8 6.02% 1.87E-04 5340, 5371, 3553, 23405, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0001944~vasculature development 9 6.77% 1.92E-04 5340, 5371, 3553, 23405, 8434, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0048514~blood vessel morphogenesis 8 6.02% 4.66E-04 5340, 5371, 3553, 23405, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0009887~organ morphogenesis 12 9.02% 5.15E-04 6347, 5340, 5371, 3553, 116039, 8626, 23405, 4838, 1490, 81575, 7057, 3491, GOTERM_BP_ALL GO:0016525~negative regulation of angiogenesis 3 2.26% 0.01179554 5340, 5371, 7057, GOTERM_BP_ALL GO:0045765~regulation of angiogenesis 3 2.26% 0.043562035 5340, 5371, 7057, Functional Group 6 Median: 4.6373346346677047E-4 Geo: 9.410839872006593E-4 5239, 5100, 25975, 1825, 11117, 3918, 667, 1490, 158326, 7057, 3491, 3909, 6347, 1308, 56963, 10332, Category Term Count % PValue Genes SP_PIR_KEYWORDS cell adhesion 12 9.02% 8.72E-05 5239, 5100, 25975, 1825, 11117, 3918, 667, 1490, 158326, 7057, 3491, 3909, GOTERM_BP_ALL GO:0022610~biological adhesion 16 12.03% 4.64E-04 6347, 1308, 56963, 1825, 10332, 25975, 11117, 1490, 667, 3491, 5239, 5100, 3918, 158326, 7057, 3909, GOTERM_BP_ALL GO:0007155~cell adhesion 16 12.03% 4.64E-04 6347, 1308, 56963, 1825, 10332, 25975, 11117, 1490, 667, 3491, 5239, 5100, 3918, 158326, 7057, 3909, GOTERM_BP_ALL GO:0016337~cell-cell adhesion 6 4.51% 0.041837592 5100, 10332, 1825, 56963, 1490, 158326,

Functional Group 7 Median: 0.0013875184457718247 Geo: 0.0014066935718820553 1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, 9705, 1991, 168667, 26166, 5187, 667, 2167, 349075, 3159, 2152, 22870, 29974, 3949, 8864, 2572, 1820, 7980, 4053, 2357, 3658, 244, 350, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0032502~developmental process 47 35.34% 7.03E-06 1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, GOTERM_BP_ALL GO:0048523~negative regulation of cellular process 21 15.79% 6.29E-04 6347, 9705, 5371, 3553, 8626, 23405, 8771, 1991, 168667, 8434, 1755, 26166, 5187, 667, 2919, 5340, 2487, 2167, 3624, 5743, 4838, GOTERM_BP_ALL GO:0048519~negative regulation of biological process 21 15.79% 0.001031429 6347, 9705, 5371, 3553, 8626, 23405, 8771, 1991, 168667, 8434, 1755, 26166, 5187, 667, 2919, 5340, 2487, 2167, 3624, 5743, 4838, GOTERM_BP_ALL GO:0065007~biological regulation 55 41.35% 0.001743608 9705, 116039, 3553, 8434, 26166, 5187, 7097, 1440, 5340, 349075, 10242, 3159, 7057, 2152, 3909, 5371, 168667, 1991, 22870, 10481, 3491, 8013, 29974, 3949, 8864, 3043, 5743, 5307, 2572, 1820, 1755, 10361, 7980, 3853, 1959, 6347, 4053, 23405, 8626, 8771, 667, 1490, 942, 2357, 2070, 3658, 244, 3899, 2919, 2487, 2167, 3624, 3853, 350, 4838, GOTERM_BP_ALL GO:0050789~regulation of biological process 47 35.34% 0.019009959 9705, 2572, 3553, 116039, 8434, 26166, 1820, 1755, 5187, 10361, 7097, 1440, 5340, 3853, 349075, 3159, 10242, 7057, 3909, 1959, 6347, 4053, 5371, 8626, 23405, 8771, 1991, 168667, 1490, 667, 942, 3491, 10481, 2070, 3899, 2919, 8013, 2487, 2167, 3624, 3853, 8864, 350, 5743, 3043, 4838, 5307, GOTERM_BP_ALL GO:0050794~regulation of cellular process 42 31.58% 0.051267826 9705, 116039, 3553, 8434, 1820, 1755, 26166, 5187, 10361, 7097, 1440, 5340, 3853, 349075, 3159, 3909, 1959, 6347, 4053, 5371, 8626, 23405, 8771, 1991, 168667, 1490, 667, 942, 3491, 10481, 2070, 3899, 2919, 8013, 2487, 2167, 3624, 3853, 8864, 5743, 4838, 5307,

Functional Group 8 Median: 0.015575461715799222 Geo: 0.002612998280529985 1308, 286887, 1825, 3853, 3854, 3918, 3853, 2709, 3861, 7057, 3885, 3909, 5743, 1490, 10481, 5340, 8013, 5307, 81851, 11117, 4060, 667, 7980, 5239, 2192, 83957, 84951, 5371, 10361, 3159, 2572, 1755, 29974, Category Term Count % PValue Genes KEGG_PATHWAY hsa01430:Cell Communication 12 9.02% 2.75E-08 1308, 286887, 1825, 3853, 3854, 3918, 3853, 2709, 3861, 7057, 3885, 3909, GOTERM_BP_ALL GO:0007398~ectoderm development 12 9.02% 3.33E-08 1308, 3853, 3854, 3918, 3853, 2709, 3861, 5743, 1490, 3885, 10481, 3909, GOTERM_BP_ALL GO:0009888~tissue development 15 11.28% 4.31E-07 1308, 2709, 1490, 10481, 5340, 8013, 3854, 3853, 3918, 3853, 3861, 5743, 3885, 3909, 5307, GOTERM_BP_ALL GO:0008544~epidermis development 9 6.77% 1.49E-05 1308, 3918, 2709, 3861, 5743, 1490, 3885, 10481, 3909, SP_PIR_KEYWORDS Keratin 7 5.26% 5.22E-05 286887, 3853, 3854, 3853, 81851, 3861, 3885, PIR_SUPERFAMILY PIRSF002282:cytoskeletal keratin 6 4.51% 1.47E-04 286887, 3853, 3854, 3853, 3861, 3885, INTERPRO IPR001664:Intermediate filament protein 6 4.51% 1.99E-04 286887, 3853, 3854, 3853, 3861, 3885, SP_PIR_KEYWORDS intermediate filament 6 4.51% 2.04E-04 286887, 3853, 3854, 3853, 3861, 3885, GOTERM_MF_ALL GO:0005198~structural molecule activity 16 12.03% 4.18E-04 1308, 11117, 4060, 81851, 667, 7980, 5239, 286887, 3854, 3853, 3853, 3861, 2192, 7057, 3885, 3909, GOTERM_CC_ALL GO:0005882~intermediate filament 7 5.26% 4.28E-04 286887, 3853, 3854, 3853, 81851, 3861, 3885, GOTERM_CC_ALL GO:0045111~intermediate filament cytoskeleton 7 5.26% 4.28E-04 286887, 3853, 3854, 3853, 81851, 3861, 3885, INTERPRO IPR003054:Type II keratin 4 3.01% 8.76E-04 286887, 3853, 3854, 3853, UP_SEQ_FEATURE site:Stutter 3 2.26% 0.005228451 3853, 3854, 3861, GOTERM_MF_ALL GO:0005200~structural constituent of cytoskeleton 5 3.76% 0.005725156 3853, 3854, 3853, 3861, 667, UP_SEQ_FEATURE region of interest:Coil 2 3 2.26% 0.025425767 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Linker 12 3 2.26% 0.032894809 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Coil 1A 3 2.26% 0.036912491 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Coil 1B 3 2.26% 0.036912491 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Linker 1 3 2.26% 0.036912491 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Rod 3 2.26% 0.038988599 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Head 3 2.26% 0.041108248 3853, 3854, 3861, UP_SEQ_FEATURE region of interest:Tail 3 2.26% 0.045474338 3853, 3854, 3861, GOTERM_CC_ALL GO:0005856~cytoskeleton 11 8.27% 0.301152158 83957, 286887, 1825, 3853, 3854, 3853, 81851, 3861, 84951, 667, 3885, GOTERM_CC_ALL GO:0044430~cytoskeletal part 7 5.26% 0.382018467 286887, 3853, 3854, 3853, 81851, 3861, 3885, GOTERM_CC_ALL GO:0043228~non-membrane-bound organelle 14 10.53% 0.605465517 5371, 1825, 84951, 81851, 667, 10361, 83957, 286887, 3854, 3853, 3861, 3853, 3159, 3885, GOTERM_CC_ALL GO:0043232~intracellular non-membrane-bound organelle 14 10.53% 0.605465517 5371, 1825, 84951, 81851, 667, 10361, 83957, 286887, 3854, 3853, 3861, 3853, 3159, 3885, GOTERM_CC_ALL GO:0044446~intracellular organelle part 13 9.77% 0.999907583 2572, 5371, 81851, 1755, 10361, 286887, 3854, 3853, 29974, 3861, 3853, 3159, 3885, GOTERM_CC_ALL GO:0044422~organelle part 13 9.77% 0.999914643 2572, 5371, 81851, 1755, 10361, 286887, 3854, 3853, 29974, 3861, 3853, 3159, 3885,

Functional Group 9 Median: 0.0031100942438274434 Geo: 0.004018807622978727 244, 5340, 350, 2152, 7057, 7980, 3949, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0007596~blood coagulation 6 4.51% 0.001198625 244, 5340, 350, 2152, 7057, 7980, GOTERM_BP_ALL GO:0050817~coagulation 6 4.51% 0.001321211 244, 5340, 350, 2152, 7057, 7980, GOTERM_BP_ALL GO:0007599~hemostasis 6 4.51% 0.00152214 244, 5340, 350, 2152, 7057, 7980, GOTERM_BP_ALL GO:0050878~regulation of body fluid levels 6 4.51% 0.003110094 244, 5340, 350, 2152, 7057, 7980, GOTERM_BP_ALL GO:0042060~wound healing 6 4.51% 0.003883621 244, 5340, 350, 2152, 7057, 7980, SP_PIR_KEYWORDS blood coagulation 4 3.01% 0.005836035 244, 5340, 2152, 7980, SP_PIR_KEYWORDS duplication 5 3.76% 0.099641987 244, 5340, 3949, 350, 7980,

Functional Group 10 Median: 0.046893468326945645 Geo: 0.009240254501446554 4053, 1825, 10332, 25975, 23213, 3241, 2202, 164633, 667, 7220, 244, 8404, 5100, 5340, 6279, 3949, 2192, 57685, 158326, 7057, 9705, 116039, 245973, 3620, 57198, 79413, 349075, 5896, 1959, 79586, 5371, 8626, 3658, 2070, 124, 3772, 5239, 8013, 5743, 3043, 25976, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0005509~calcium ion binding 20 15.04% 6.74E-05 4053, 1825, 10332, 25975, 23213, 3241, 2202, 164633, 667, 7220, 244, 8404, 5100, 5340, 6279, 3949, 2192, 57685, 158326, 7057, SP_PIR_KEYWORDS calcium 17 12.78% 6.81E-05 1825, 10332, 25975, 23213, 3241, 2202, 164633, 667, 7220, 244, 8404, 5100, 6279, 2192, 57685, 158326, 7057, GOTERM_MF_ALL GO:0046872~metal ion binding 41 30.83% 0.040182844 9705, 116039, 1825, 10332, 23213, 164633, 245973, 3620, 8404, 57198, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 79586, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 2070, 124, 3772, 244, 5239, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, GOTERM_MF_ALL GO:0043167~ion binding 41 30.83% 0.053604093 9705, 116039, 1825, 10332, 23213, 164633, 245973, 3620, 8404, 57198, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 79586, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 2070, 124, 3772, 244, 5239, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, GOTERM_MF_ALL GO:0043169~cation binding 36 27.07% 0.106669537 9705, 116039, 1825, 10332, 23213, 164633, 3620, 8404, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 124, 3772, 244, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, SP_PIR_KEYWORDS metal-binding 20 15.04% 0.589617518 9705, 79586, 5371, 116039, 10332, 8626, 23213, 3620, 3658, 124, 5239, 57198, 8013, 79413, 5743, 3043, 349075, 5896, 158326, 1959,

Functional Group 11 Median: 0.01024644720649838 Geo: 0.010012207924506203 3918, 350, 1490, 7057, 3491, 7097, 168667, 10332, 158326, Category Term Count % PValue Genes SP_PIR_KEYWORDS heparin-binding 5 3.76% 0.001436602 3918, 350, 1490, 7057, 3491, GOTERM_MF_ALL GO:0001871~pattern binding 6 4.51% 0.002943656 3918, 350, 1490, 7057, 3491, 7097, INTERPRO IPR001007:von Willebrand factor, type C 4 3.01% 0.004020119 168667, 1490, 7057, 3491, GOTERM_MF_ALL GO:0008201~heparin binding 5 3.76% 0.004132566 3918, 350, 1490, 7057, 3491, SMART SM00214:VWC 4 3.01% 0.005469158 168667, 1490, 7057, 3491, GOTERM_MF_ALL GO:0005539~glycosaminoglycan binding 5 3.76% 0.010036841 3918, 350, 1490, 7057, 3491, UP_SEQ_FEATURE domain:VWFC 3 2.26% 0.010456054 1490, 7057, 3491, UP_SEQ_FEATURE region of interest:Heparin-binding 3 2.26% 0.010456054 1490, 7057, 3491, GOTERM_MF_ALL GO:0030247~polysaccharide binding 5 3.76% 0.011571008 3918, 350, 1490, 7057, 3491, GOTERM_MF_ALL GO:0030246~carbohydrate binding 7 5.26% 0.029374199 10332, 3918, 350, 1490, 158326, 7057, 3491, INTERPRO IPR000884:Thrombospondin, type I 3 2.26% 0.075141284 1490, 7057, 3491, SMART SM00209:TSP1 3 2.26% 0.094233865 1490, 7057, 3491,

Functional Group 12 Median: 0.011652625671637665 Geo: 0.011118615990799233 64388, 1490, 3491, Category Term Count % PValue Genes UP_SEQ_FEATURE domain:CTCK 3 2.26% 0.008169825 64388, 1490, 3491, INTERPRO IPR006207:Cystine knot, C-terminal 3 2.26% 0.011652626 64388, 1490, 3491, SMART SM00041:CT 3 2.26% 0.014438285 64388, 1490, 3491,

Functional Group 13 Median: 0.0055640617461827566 Geo: 0.012148295952912024 5268, 5340, 3553, 1991, 5743, 4838, 1490, 2357, 7057, 3909, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0051674~localization of cell 10 7.52% 0.005564062 5268, 5340, 3553, 1991, 5743, 4838, 1490, 2357, 7057, 3909, GOTERM_BP_ALL GO:0006928~cell motility 10 7.52% 0.005564062 5268, 5340, 3553, 1991, 5743, 4838, 1490, 2357, 7057, 3909, GOTERM_BP_ALL GO:0016477~cell migration 6 4.51% 0.057911153 5340, 3553, 1991, 4838, 1490, 3909,

Functional Group 14 Median: 0.017546341647388886 Geo: 0.012450240281655048 4053, 25975, 3949, 3918, 5743, 2202, 2192, 7057, 3909, Category Term Count % PValue Genes INTERPRO IPR013032:EGF-like region 9 6.77% 0.001637629 4053, 25975, 3949, 3918, 5743, 2202, 2192, 7057, 3909, INTERPRO IPR013091:EGF calcium-binding 5 3.76% 0.002734379 4053, 25975, 3949, 2202, 2192, INTERPRO IPR000742:EGF-like, type 3 7 5.26% 0.003467711 4053, 25975, 3949, 5743, 2202, 2192, 7057, UP_SEQ_FEATURE domain:EGF-like 2; calcium-binding 4 3.01% 0.004702904 3949, 2202, 2192, 7057, INTERPRO IPR001881:EGF-like calcium-binding 5 3.76% 0.007827514 4053, 25975, 3949, 2202, 2192, INTERPRO IPR000152:Aspartic acid and asparagine hydroxylation site 5 3.76% 0.008133523 4053, 25975, 3949, 2202, 2192, SMART SM00179:EGF_CA 5 3.76% 0.012252507 4053, 25975, 3949, 2202, 2192, INTERPRO IPR006210:EGF 6 4.51% 0.017546342 4053, 25975, 3949, 5743, 2192, 7057, UP_SEQ_FEATURE domain:EGF-like 6; calcium-binding 3 2.26% 0.018767653 4053, 2202, 2192, UP_SEQ_FEATURE domain:EGF-like 3; calcium-binding 3 2.26% 0.020352375 4053, 2202, 2192, SP_PIR_KEYWORDS egf-like domain 6 4.51% 0.025615085 4053, 25975, 3949, 2202, 2192, 7057, SMART SM00181:EGF 6 4.51% 0.027154867 4053, 25975, 3949, 5743, 2192, 7057, UP_SEQ_FEATURE domain:EGF-like 5; calcium-binding 3 2.26% 0.030955226 4053, 2202, 2192, UP_SEQ_FEATURE domain:EGF-like 1 4 3.01% 0.032918907 4053, 3949, 2192, 7057, INTERPRO IPR006209:EGF-like 4 3.01% 0.098928334 4053, 3949, 5743, 7057, Functional Group 15 Median: 0.02313907011258074 Geo: 0.02717843897998975 2167, 1991, 5743, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0050727~regulation of inflammatory response 3 2.26% 0.02313907 2167, 1991, 5743, GOTERM_BP_ALL GO:0031347~regulation of defense response 3 2.26% 0.02313907 2167, 1991, 5743, GOTERM_BP_ALL GO:0048583~regulation of response to stimulus 3 2.26% 0.037495722 2167, 1991, 5743,

Functional Group 16 Median: 0.06901446711888115 Geo: 0.030143195240571352 5100, 8013, 116039, 56963, 23405, 4838, 10361, 3491, 3909, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0009790~embryonic development 9 6.77% 0.002354465 5100, 8013, 116039, 56963, 23405, 4838, 10361, 3491, 3909, GOTERM_BP_ALL GO:0043009~chordate embryonic development 4 3.01% 0.069014467 5100, 116039, 56963, 4838, GOTERM_BP_ALL GO:0009792~embryonic development ending in birth or egg hatching 4 3.01% 0.069014467 5100, 116039, 56963, 4838, GOTERM_BP_ALL GO:0048598~embryonic morphogenesis 4 3.01% 0.073618092 5100, 116039, 56963, 23405,

Functional Group 17 Median: 0.056948683177444795 Geo: 0.030372978974095872 1440, 2919, 5340, 3553, 116039, 3853, 1991, 3853, 5743, 4838, 942, 3491, 5371, 8626, 7097, 3624, 3159, 3043, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0042127~regulation of cell proliferation 11 8.27% 0.007823422 1440, 2919, 5340, 3553, 116039, 3853, 1991, 3853, 5743, 4838, 942, GOTERM_BP_ALL GO:0008284~positive regulation of cell proliferation 7 5.26% 0.01382451 1440, 116039, 3853, 1991, 3853, 4838, 942, GOTERM_BP_ALL GO:0008283~cell proliferation 12 9.02% 0.056948683 1440, 2919, 5340, 3553, 116039, 3853, 1991, 3853, 5743, 4838, 942, 3491, GOTERM_BP_ALL GO:0048522~positive regulation of cellular process 14 10.53% 0.062989991 5371, 116039, 3553, 8626, 1991, 942, 7097, 1440, 5340, 3853, 3624, 3853, 4838, 3159, GOTERM_BP_ALL GO:0048518~positive regulation of biological process 15 11.28% 0.066624696 5371, 116039, 3553, 8626, 1991, 942, 7097, 1440, 5340, 3624, 3853, 3853, 3043, 4838, 3159,

Functional Group 18 Median: 0.10133906901294396 Geo: 0.05524095278644011 6347, 2919, 9547, 3553, 1991, 2357, 3491, 2167, 3949, 10242, 3658, 5340, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0042330~taxis 7 5.26% 0.001178295 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_BP_ALL GO:0006935~chemotaxis 7 5.26% 0.001178295 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_BP_ALL GO:0007626~locomotory behavior 7 5.26% 0.004458995 6347, 2919, 9547, 3553, 1991, 2357, 3491, GOTERM_BP_ALL GO:0048878~chemical homeostasis 7 5.26% 0.018461187 6347, 3553, 2167, 1991, 3949, 10242, 3658, GOTERM_BP_ALL GO:0042592~homeostatic process 8 6.02% 0.040066258 6347, 5340, 3553, 2167, 1991, 3949, 10242, 3658, GOTERM_BP_ALL GO:0055082~cellular chemical homeostasis 5 3.76% 0.079302036 6347, 3553, 1991, 10242, 3658, GOTERM_BP_ALL GO:0006873~cellular ion homeostasis 5 3.76% 0.079302036 6347, 3553, 1991, 10242, 3658, GOTERM_BP_ALL GO:0019725~cellular homeostasis 6 4.51% 0.086245131 6347, 5340, 3553, 1991, 10242, 3658, GOTERM_BP_ALL GO:0050801~ion homeostasis 5 3.76% 0.101339069 6347, 3553, 1991, 10242, 3658, GOTERM_BP_ALL GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 4 3.01% 0.120677506 6347, 3553, 1991, 3658, GOTERM_BP_ALL GO:0055066~di-, tri-valent inorganic cation homeostasis 4 3.01% 0.122596253 6347, 3553, 1991, 3658, GOTERM_BP_ALL GO:0030003~cellular cation homeostasis 4 3.01% 0.158924384 6347, 3553, 1991, 3658, GOTERM_BP_ALL GO:0055080~cation homeostasis 4 3.01% 0.161033313 6347, 3553, 1991, 3658, GOTERM_BP_ALL GO:0055074~calcium ion homeostasis 3 2.26% 0.244269614 6347, 3553, 1991, GOTERM_BP_ALL GO:0006874~cellular calcium ion homeostasis 3 2.26% 0.244269614 6347, 3553, 1991, GOTERM_BP_ALL GO:0055065~metal ion homeostasis 3 2.26% 0.270279896 6347, 3553, 1991, GOTERM_BP_ALL GO:0006875~cellular metal ion homeostasis 3 2.26% 0.270279896 6347, 3553, 1991,

Functional Group 19 Median: 0.03683775227210732 Geo: 0.05849995812411618 1308, 667, 3909, 5239, 2572, 1825, 2709, 84951, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0030055~cell-matrix junction 3 2.26% 0.034370809 1308, 667, 3909, GOTERM_CC_ALL GO:0030054~cell junction 8 6.02% 0.036837752 5239, 1308, 2572, 1825, 2709, 84951, 667, 3909, GOTERM_CC_ALL GO:0016323~basolateral plasma membrane 3 2.26% 0.158118902 1308, 667, 3909,

Functional Group 20 Median: 0.03683775227210732 Geo: 0.06366271243127902 5239, 1308, 1825, 2709, 667, 2572, 84951, 3909, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0005911~intercellular junction 5 3.76% 0.034972295 5239, 1308, 1825, 2709, 667, GOTERM_CC_ALL GO:0030054~cell junction 8 6.02% 0.036837752 5239, 1308, 2572, 1825, 2709, 84951, 667, 3909, SP_PIR_KEYWORDS cell junction 5 3.76% 0.200280266 5239, 2572, 1825, 2709, 84951,

Functional Group 21 Median: 0.09164905936485288 Geo: 0.08839463965791189 8404, 6279, 5371, 3241, 164633, 667, Category Term Count % PValue Genes INTERPRO IPR002048:Calcium-binding EF-hand 6 4.51% 0.037685396 8404, 6279, 5371, 3241, 164633, 667, SMART SM00054:EFh 6 4.51% 0.055604247 8404, 6279, 5371, 3241, 164633, 667, SP_PIR_KEYWORDS EF hand 3 2.26% 0.063514895 8404, 6279, 3241, UP_SEQ_FEATURE domain:EF-hand 1 4 3.01% 0.089845133 6279, 3241, 164633, 667, UP_SEQ_FEATURE domain:EF-hand 2 4 3.01% 0.093452985 6279, 3241, 164633, 667, INTERPRO IPR011992:EF-Hand type 5 3.76% 0.099643506 8404, 6279, 3241, 164633, 667, UP_SEQ_FEATURE calcium-binding region:2 3 2.26% 0.178049702 3241, 164633, 667, UP_SEQ_FEATURE calcium-binding region:1 3 2.26% 0.188006479 3241, 164633, 667,

Functional Group 22 Median: 0.09194688457804112 Geo: 0.09682887034549297 3553, 2167, 3624, 1991, 942, 7097, 3043, 5371, 8626, 3159, 2572, 5743, 3067, 245973, 3949, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0001816~cytokine production 6 4.51% 0.003354276 3553, 2167, 3624, 1991, 942, 7097, GOTERM_BP_ALL GO:0042035~regulation of cytokine biosynthetic process 4 3.01% 0.017000799 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0042089~cytokine biosynthetic process 4 3.01% 0.024288041 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0009891~positive regulation of biosynthetic process 4 3.01% 0.024288041 3553, 1991, 3043, 942, GOTERM_BP_ALL GO:0042107~cytokine metabolic process 4 3.01% 0.025186592 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0051247~positive regulation of protein metabolic process 4 3.01% 0.0419599 5371, 3553, 1991, 942, GOTERM_BP_ALL GO:0042108~positive regulation of cytokine biosynthetic process 3 2.26% 0.04996551 3553, 1991, 942, GOTERM_BP_ALL GO:0009893~positive regulation of metabolic process 8 6.02% 0.075441183 5371, 3553, 8626, 3624, 1991, 3043, 3159, 942, GOTERM_BP_ALL GO:0045727~positive regulation of translation 3 2.26% 0.081107294 3553, 1991, 942, GOTERM_BP_ALL GO:0009889~regulation of biosynthetic process 5 3.76% 0.091946885 3553, 3624, 1991, 3043, 942, GOTERM_BP_ALL GO:0031328~positive regulation of cellular biosynthetic process 3 2.26% 0.099785527 3553, 1991, 942, GOTERM_BP_ALL GO:0006417~regulation of translation 4 3.01% 0.169553893 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0031326~regulation of cellular biosynthetic process 4 3.01% 0.202585857 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0051246~regulation of protein metabolic process 5 3.76% 0.236142974 5371, 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0031325~positive regulation of cellular metabolic process 6 4.51% 0.263228149 3553, 8626, 3624, 1991, 3159, 942, GOTERM_BP_ALL GO:0044249~cellular biosynthetic process 9 6.77% 0.523468071 2572, 3553, 3624, 1991, 5743, 3043, 3067, 245973, 942, GOTERM_BP_ALL GO:0009058~biosynthetic process 10 7.52% 0.747661397 2572, 3553, 3624, 1991, 3949, 5743, 3043, 3067, 245973, 942, GOTERM_BP_ALL GO:0006412~translation 4 3.01% 0.749529885 3553, 3624, 1991, 942, GOTERM_BP_ALL GO:0009059~macromolecule biosynthetic process 5 3.76% 0.867928367 3553, 3624, 1991, 3949, 942,

Functional Group 23 Median: 0.15600612266718716 Geo: 0.1275615252955521 5340, 5371, 8626, 3624, 5743, 1490, 3491, 10481, 7097, 6347, 3553, 23213, 8771, 84951, 23405, 4838, 5896, 1959, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0040007~growth 8 6.02% 0.00878629 5340, 5371, 8626, 3624, 5743, 1490, 3491, 10481, GOTERM_BP_ALL GO:0040008~regulation of growth 6 4.51% 0.025658018 5371, 8626, 3624, 1490, 3491, 10481, GOTERM_BP_ALL GO:0001558~regulation of cell growth 5 3.76% 0.037620979 5371, 8626, 3624, 1490, 3491, GOTERM_BP_ALL GO:0016049~cell growth 5 3.76% 0.066484597 5371, 8626, 3624, 1490, 3491, GOTERM_BP_ALL GO:0008361~regulation of cell size 5 3.76% 0.07216613 5371, 8626, 3624, 1490, 3491, GOTERM_BP_ALL GO:0030308~negative regulation of cell growth 3 2.26% 0.081107294 5371, 8626, 3624, GOTERM_BP_ALL GO:0045792~negative regulation of cell size 3 2.26% 0.08370297 5371, 8626, 3624, GOTERM_BP_ALL GO:0006917~induction of apoptosis 5 3.76% 0.095918703 5340, 5371, 8626, 3624, 7097, GOTERM_BP_ALL GO:0012502~induction of programmed cell death 5 3.76% 0.097260535 5340, 5371, 8626, 3624, 7097, GOTERM_BP_ALL GO:0045926~negative regulation of growth 3 2.26% 0.10812648 5371, 8626, 3624, GOTERM_BP_ALL GO:0043065~positive regulation of apoptosis 5 3.76% 0.154354175 5340, 5371, 8626, 3624, 7097, GOTERM_BP_ALL GO:0043068~positive regulation of programmed cell death 5 3.76% 0.15765807 5340, 5371, 8626, 3624, 7097, GOTERM_BP_ALL GO:0006915~apoptosis 10 7.52% 0.179050699 6347, 5340, 5371, 3553, 8626, 23213, 3624, 8771, 84951, 7097, GOTERM_BP_ALL GO:0012501~programmed cell death 10 7.52% 0.185111466 6347, 5340, 5371, 3553, 8626, 23213, 3624, 8771, 84951, 7097, GOTERM_BP_ALL GO:0048468~cell development 14 10.53% 0.189634158 6347, 5371, 3553, 23405, 23213, 8626, 8771, 84951, 7097, 5340, 3624, 4838, 5896, 1959, GOTERM_BP_ALL GO:0016265~death 10 7.52% 0.228883539 6347, 5340, 5371, 3553, 8626, 23213, 3624, 8771, 84951, 7097, GOTERM_BP_ALL GO:0008219~cell death 10 7.52% 0.228883539 6347, 5340, 5371, 3553, 8626, 23213, 3624, 8771, 84951, 7097, GOTERM_BP_ALL GO:0042981~regulation of apoptosis 7 5.26% 0.267988214 6347, 5340, 5371, 8626, 3624, 8771, 7097, GOTERM_BP_ALL GO:0043067~regulation of programmed cell death 7 5.26% 0.275497601 6347, 5340, 5371, 8626, 3624, 8771, 7097, SP_PIR_KEYWORDS apoptosis 4 3.01% 0.437602877 8626, 23213, 8771, 84951, GOTERM_BP_ALL GO:0032989~cellular structure morphogenesis 5 3.76% 0.541778912 5371, 8626, 3624, 1490, 3491, GOTERM_BP_ALL GO:0000902~cell morphogenesis 5 3.76% 0.541778912 5371, 8626, 3624, 1490, 3491, Functional Group 24 Median: 0.1491913923955043 Geo: 0.1440508505553295 23405, 3624, 4838, 942, 3909, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0045596~negative regulation of cell differentiation 3 2.26% 0.122418534 23405, 3624, 4838, GOTERM_BP_ALL GO:0045595~regulation of cell differentiation 4 3.01% 0.142380011 23405, 3624, 4838, 942, GOTERM_BP_ALL GO:0050793~regulation of developmental process 5 3.76% 0.156002774 23405, 3624, 4838, 942, 3909, GOTERM_BP_ALL GO:0051093~negative regulation of developmental process 3 2.26% 0.158356098 23405, 3624, 4838,

Functional Group 25 Median: 0.2081382444433082 Geo: 0.1701804814342307 79442, 4060, 25960, 7097, 4969, Category Term Count % PValue Genes INTERPRO IPR003591:Leucine-rich repeat, typical subtype 4 3.01% 0.066516915 79442, 4060, 25960, 7097, SMART SM00369:LRR_TYP 4 3.01% 0.08643779 79442, 4060, 25960, 7097, INTERPRO IPR001611:Leucine-rich repeat 5 3.76% 0.110733435 79442, 4060, 25960, 4969, 7097, SP_PIR_KEYWORDS leucine-rich repeat 5 3.76% 0.119494651 79442, 4060, 25960, 4969, 7097, UP_SEQ_FEATURE repeat:LRR 5 3 2.26% 0.208138244 79442, 25960, 7097, UP_SEQ_FEATURE repeat:LRR 4 3 2.26% 0.255816741 79442, 25960, 7097, UP_SEQ_FEATURE repeat:LRR 3 3 2.26% 0.293480578 79442, 25960, 7097, UP_SEQ_FEATURE repeat:LRR 1 3 2.26% 0.317345438 79442, 25960, 7097, UP_SEQ_FEATURE repeat:LRR 2 3 2.26% 0.317345438 79442, 25960, 7097,

Functional Group 26 Median: 0.27540200941577264 Geo: 0.1774467240344199 5743, 3043, 3620, 3658, 124, Category Term Count % PValue Genes SP_PIR_KEYWORDS metalloprotein 5 3.76% 0.01723865 5743, 3043, 3620, 3658, 124, SP_PIR_KEYWORDS heme 3 2.26% 0.211335048 5743, 3043, 3620, GOTERM_MF_ALL GO:0020037~heme binding 3 2.26% 0.275402009 5743, 3043, 3620, GOTERM_MF_ALL GO:0046906~tetrapyrrole binding 3 2.26% 0.275402009 5743, 3043, 3620, SP_PIR_KEYWORDS iron 4 3.01% 0.278495589 5743, 3043, 3620, 3658, GOTERM_MF_ALL GO:0005506~iron ion binding 4 3.01% 0.405677203 5743, 3043, 3620, 3658,

Functional Group 27 Median: 0.17032633756316398 Geo: 0.2170423143353883 5268, 8434, 7057, 7980, 2919, 2192, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0004866~endopeptidase inhibitor activity 4 3.01% 0.101860667 5268, 8434, 7057, 7980, GOTERM_MF_ALL GO:0030414~protease inhibitor activity 4 3.01% 0.10554799 5268, 8434, 7057, 7980, GOTERM_MF_ALL GO:0004867~serine-type endopeptidase inhibitor activity 3 2.26% 0.170326338 5268, 8434, 7980, GOTERM_MF_ALL GO:0004857~enzyme inhibitor activity 4 3.01% 0.342274699 5268, 8434, 7057, 7980, GOTERM_MF_ALL GO:0030234~enzyme regulator activity 6 4.51% 0.768438242 5268, 2919, 8434, 2192, 7057, 7980,

Functional Group 28 Median: 0.9146734576312385 Geo: 0.24675334900200352 5743, 3043, 3620, 3658, 124, 7097, Category Term Count % PValue Genes SP_PIR_KEYWORDS metalloprotein 5 3.76% 0.01723865 5743, 3043, 3620, 3658, 124, SP_PIR_KEYWORDS oxidoreductase 3 2.26% 0.914673458 5743, 3620, 124, GOTERM_MF_ALL GO:0016491~oxidoreductase activity 4 3.01% 0.95283968 5743, 3620, 124, 7097,

Functional Group 29 Median: 0.2605165906092213 Geo: 0.25378747779078853 1440, 3624, 5896, 942, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0002521~leukocyte differentiation 4 3.01% 0.063089977 1440, 3624, 5896, 942, GOTERM_BP_ALL GO:0030098~lymphocyte differentiation 3 2.26% 0.140131183 3624, 5896, 942, GOTERM_BP_ALL GO:0030097~hemopoiesis 4 3.01% 0.216205714 1440, 3624, 5896, 942, GOTERM_BP_ALL GO:0048534~hemopoietic or lymphoid organ development 4 3.01% 0.246332332 1440, 3624, 5896, 942, GOTERM_BP_ALL GO:0002520~immune system development 4 3.01% 0.27470085 1440, 3624, 5896, 942, GOTERM_BP_ALL GO:0046649~lymphocyte activation 3 2.26% 0.443522709 3624, 5896, 942, GOTERM_BP_ALL GO:0045321~leukocyte activation 3 2.26% 0.514923716 3624, 5896, 942, GOTERM_BP_ALL GO:0001775~cell activation 3 2.26% 0.582584619 3624, 5896, 942,

Functional Group 30 Median: 0.30086072205747855 Geo: 0.26189984158962326 6347, 3598, 10560, 10332, 3553, 8771, 1755, 26166, 5187, 2357, 942, 7097, 5157, 8013, 3624, 8864, 3949, 54210, 25960, 2152, 7057, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0060089~molecular transducer activity 21 15.79% 0.132814489 6347, 3598, 10560, 10332, 3553, 8771, 1755, 26166, 5187, 2357, 942, 7097, 5157, 8013, 3624, 8864, 3949, 54210, 25960, 2152, 7057, GOTERM_MF_ALL GO:0004871~signal transducer activity 21 15.79% 0.132814489 6347, 3598, 10560, 10332, 3553, 8771, 1755, 26166, 5187, 2357, 942, 7097, 5157, 8013, 3624, 8864, 3949, 54210, 25960, 2152, 7057, GOTERM_MF_ALL GO:0004888~transmembrane receptor activity 10 7.52% 0.300860722 5157, 3598, 10560, 10332, 3949, 1755, 25960, 2357, 2152, 7097, GOTERM_MF_ALL GO:0004872~receptor activity 14 10.53% 0.409016872 10560, 3598, 10332, 8771, 1755, 942, 2357, 7097, 5157, 8013, 3949, 54210, 25960, 2152, SP_PIR_KEYWORDS receptor 10 7.52% 0.567647267 3598, 8013, 10332, 8771, 3949, 54210, 25960, 2357, 942, 7097,

Functional Group 31 Median: 0.383881674994738 Geo: 0.2706322574604514 6347, 10560, 4053, 3553, 8626, 168667, 1490, 667, 2357, 7097, 1440, 2919, 2487, 3624, 25960, 3159, 3909, 9547, 2572, 4680, 10332, 2709, 26166, 5187, 54210, 10242, 1959, 84951, 942, 5100, 8864, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0007166~cell surface receptor linked signal transduction 17 12.78% 0.078039135 6347, 10560, 4053, 3553, 8626, 168667, 1490, 667, 2357, 7097, 1440, 2919, 2487, 3624, 25960, 3159, 3909, GOTERM_BP_ALL GO:0007154~cell communication 31 23.31% 0.383881675 9547, 2572, 10560, 4680, 10332, 3553, 2709, 26166, 5187, 7097, 1440, 54210, 3159, 10242, 3909, 1959, 6347, 4053, 8626, 168667, 84951, 1490, 667, 2357, 942, 2919, 5100, 2487, 3624, 8864, 25960, GOTERM_BP_ALL GO:0007165~signal transduction 25 18.80% 0.66165082 9547, 10560, 4680, 10332, 3553, 26166, 5187, 7097, 1440, 54210, 3159, 3909, 6347, 4053, 8626, 168667, 84951, 667, 1490, 2357, 2919, 2487, 3624, 8864, 25960,

Functional Group 32 Median: 0.2810603870216252 Geo: 0.2758137180262049 5371, 3624, 8434, 1755, 667, 4053, 3553, 10361, 25975, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0045786~negative regulation of progression through cell cycle 5 3.76% 0.097260535 5371, 3624, 8434, 1755, 667, GOTERM_BP_ALL GO:0000074~regulation of progression through cell cycle 8 6.02% 0.148655025 4053, 5371, 3553, 3624, 8434, 1755, 667, 10361, GOTERM_BP_ALL GO:0051726~regulation of cell cycle 8 6.02% 0.151906034 4053, 5371, 3553, 3624, 8434, 1755, 667, 10361, GOTERM_BP_ALL GO:0007050~cell cycle arrest 3 2.26% 0.152230449 5371, 3624, 667, GOTERM_BP_ALL GO:0022402~cell cycle process 8 6.02% 0.409890325 4053, 5371, 3553, 3624, 8434, 1755, 667, 10361, GOTERM_BP_ALL GO:0007049~cell cycle 9 6.77% 0.422970893 4053, 5371, 25975, 3553, 3624, 8434, 1755, 667, 10361, GOTERM_BP_ALL GO:0000278~mitotic cell cycle 3 2.26% 0.738357138 5371, 3624, 10361, GOTERM_BP_ALL GO:0022403~cell cycle phase 3 2.26% 0.782509234 5371, 3624, 10361,

Functional Group 33 Median: 0.22349016025557839 Geo: 0.2787139952930022 5340, 1991, 2191, 5408, 5239, 1513, 827, Category Term Count % PValue Genes UP_SEQ_FEATURE active site:Charge relay system 4 3.01% 0.108466495 5340, 1991, 2191, 5408, GOTERM_MF_ALL GO:0004252~serine-type endopeptidase activity 4 3.01% 0.145098673 5239, 5340, 1991, 2191, GOTERM_MF_ALL GO:0008236~serine-type peptidase activity 4 3.01% 0.181940676 5239, 5340, 1991, 2191, GOTERM_MF_ALL GO:0017171~serine hydrolase activity 4 3.01% 0.184183283 5239, 5340, 1991, 2191, GOTERM_MF_ALL GO:0004175~endopeptidase activity 6 4.51% 0.206653356 5239, 5340, 1513, 1991, 2191, 827, SP_PIR_KEYWORDS serine protease 3 2.26% 0.240326964 5340, 1991, 2191, SP_PIR_KEYWORDS Zymogen 3 2.26% 0.462842778 5340, 1513, 1991, GOTERM_MF_ALL GO:0008233~peptidase activity 6 4.51% 0.529449974 5239, 5340, 1513, 1991, 2191, 827, SP_PIR_KEYWORDS protease 4 3.01% 0.66217817 5340, 1513, 1991, 2191, GOTERM_BP_ALL GO:0006508~proteolysis 6 4.51% 0.665534327 5239, 5340, 1513, 1991, 2191, 827,

Functional Group 34 Median: 0.2872950935471717 Geo: 0.32505063289354486 9705, 5371, 8626, 2167, 3624, 1991, 5187, 942, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0031324~negative regulation of cellular metabolic process 7 5.26% 0.094188893 9705, 5371, 8626, 2167, 3624, 1991, 5187, GOTERM_BP_ALL GO:0009892~negative regulation of metabolic process 7 5.26% 0.139762767 9705, 5371, 8626, 2167, 3624, 1991, 5187, GOTERM_BP_ALL GO:0016481~negative regulation of transcription 5 3.76% 0.224886708 9705, 5371, 8626, 2167, 5187, GOTERM_BP_ALL GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic5 acid3.76% metabolic0.276514289 process 9705, 5371, 8626, 2167, 5187, GOTERM_MF_ALL GO:0016564~transcription repressor activity 4 3.01% 0.298075898 9705, 5371, 8626, 2167, SP_PIR_KEYWORDS ubl conjugation 4 3.01% 0.576438979 5371, 8626, 5187, 942, GOTERM_BP_ALL GO:0006357~regulation of transcription from RNA polymerase II promoter 3 2.26% 0.907460302 9705, 8626, 3624, GOTERM_BP_ALL GO:0006366~transcription from RNA polymerase II promoter 3 2.26% 0.976399941 9705, 8626, 3624,

Functional Group 35 Median: 0.3215593675435438 Geo: 0.3296374565665529 56963, 4680, 8434, 244, 2167, 81575, Category Term Count % PValue Genes SP_PIR_KEYWORDS gpi-anchor 3 2.26% 0.243563378 56963, 4680, 8434, GOTERM_MF_ALL GO:0048503~GPI anchor binding 3 2.26% 0.262103122 56963, 4680, 8434, GOTERM_MF_ALL GO:0008289~lipid binding 6 4.51% 0.300844036 244, 56963, 4680, 2167, 8434, 81575, GOTERM_MF_ALL GO:0005543~phospholipid binding 4 3.01% 0.342274699 244, 56963, 4680, 8434, UP_SEQ_FEATURE propeptide:Removed in mature form 3 2.26% 0.400642151 56963, 4680, 8434, GOTERM_MF_ALL GO:0035091~phosphoinositide binding 3 2.26% 0.487149547 56963, 4680, 8434, Functional Group 36 Median: 0.5007303661952879 Geo: 0.346231771462361 5371, 3553, 8626, 3624, 1991, 3043, 3159, 942, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0009893~positive regulation of metabolic process 8 6.02% 0.075441183 5371, 3553, 8626, 3624, 1991, 3043, 3159, 942, GOTERM_BP_ALL GO:0031325~positive regulation of cellular metabolic process 6 4.51% 0.263228149 3553, 8626, 3624, 1991, 3159, 942, GOTERM_MF_ALL GO:0016563~transcription activator activity 4 3.01% 0.490237259 5371, 8626, 3159, 942, GOTERM_BP_ALL GO:0045941~positive regulation of transcription 4 3.01% 0.511223474 8626, 3624, 3159, 942, GOTERM_BP_ALL GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic4 acid3.01% metabolic0.532780858 process 8626, 3624, 3159, 942, GOTERM_BP_ALL GO:0045893~positive regulation of transcription, DNA-dependent 3 2.26% 0.649673229 8626, 3624, 3159,

Functional Group 37 Median: 0.4230134270284695 Geo: 0.40537662934797497 4680, 54210, 942, 5157, 25960, Category Term Count % PValue Genes UP_SEQ_FEATURE domain:Ig-like V-type 3 2.26% 0.151966617 4680, 54210, 942, INTERPRO IPR013106:Immunoglobulin V-set 3 2.26% 0.354179276 4680, 54210, 942, SP_PIR_KEYWORDS immunoglobulin domain 5 3.76% 0.372420449 5157, 4680, 54210, 25960, 942, INTERPRO IPR003599:Immunoglobulin subtype 4 3.01% 0.423013427 5157, 4680, 54210, 25960, SMART SM00409:IG 4 3.01% 0.533013049 5157, 4680, 54210, 25960, INTERPRO IPR007110:Immunoglobulin-like 4 3.01% 0.600742951 5157, 4680, 25960, 942, INTERPRO IPR013783:Immunoglobulin-like fold 4 3.01% 0.662560304 5157, 4680, 54210, 942,

Functional Group 38 Median: 0.4870725730794933 Geo: 0.5365336178038814 2572, 10560, 4060, 3949, 5743, 2202, 3043, 10242, 2070, 1959, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0003008~system process 10 7.52% 0.459605377 2572, 10560, 4060, 3949, 5743, 2202, 3043, 10242, 2070, 1959, GOTERM_BP_ALL GO:0007601~visual perception 3 2.26% 0.487072573 4060, 2202, 2070, GOTERM_BP_ALL GO:0050953~sensory perception of light stimulus 3 2.26% 0.487072573 4060, 2202, 2070, GOTERM_BP_ALL GO:0050877~neurological system process 7 5.26% 0.587400586 2572, 10560, 4060, 2202, 10242, 2070, 1959, GOTERM_BP_ALL GO:0007600~sensory perception 4 3.01% 0.694189224 10560, 4060, 2202, 2070,

Functional Group 39 Median: 0.769847878476591 Geo: 0.545238438587591 1308, 2572, 10332, 4680, 1825, 2709, 84951, 667, 942, 7220, 7097, 3772, 5239, 5100, 3949, 5743, 10242, 3909, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0044459~plasma membrane part 18 13.53% 0.268977949 1308, 2572, 10332, 4680, 1825, 2709, 84951, 667, 942, 7220, 7097, 3772, 5239, 5100, 3949, 5743, 10242, 3909, GOTERM_CC_ALL GO:0005887~integral to plasma membrane 9 6.77% 0.769847878 1308, 5100, 10332, 4680, 3949, 10242, 7220, 3772, 7097, GOTERM_CC_ALL GO:0031226~intrinsic to plasma membrane 9 6.77% 0.782776539 1308, 5100, 10332, 4680, 3949, 10242, 7220, 3772, 7097,

Functional Group 40 Median: 0.707999025888644 Geo: 0.5574292204126935 57198, 6291, 3949, 350, 1308, 10560, 10332, 3553, 11117, 245973, 7097, 5340, 10242, 7057, 3909, 4053, 1991, 667, 1490, 81575, 2357, 7220, 3772, 5268, 2167, 3624, 3043, 5743, 4838, 57685, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0005319~lipid transporter activity 4 3.01% 0.027670931 57198, 6291, 3949, 350, GOTERM_BP_ALL GO:0051179~localization 28 21.05% 0.222552873 1308, 10560, 10332, 3553, 11117, 245973, 7097, 5340, 57198, 10242, 7057, 3909, 4053, 1991, 667, 1490, 81575, 2357, 7220, 3772, 5268, 2167, 3624, 3949, 3043, 5743, 4838, 57685, GOTERM_BP_ALL GO:0006812~cation transport 6 4.51% 0.357868703 57198, 245973, 10242, 57685, 7220, 3772, GOTERM_BP_ALL GO:0006811~ion transport 8 6.02% 0.38221214 1308, 57198, 11117, 245973, 10242, 57685, 7220, 3772, GOTERM_MF_ALL GO:0022892~substrate-specific transporter activity 10 7.52% 0.402005801 57198, 10560, 6291, 3949, 350, 3043, 245973, 10242, 7220, 3772, SP_PIR_KEYWORDS ion transport 5 3.76% 0.530597306 245973, 10242, 57685, 7220, 3772, GOTERM_MF_ALL GO:0005215~transporter activity 11 8.27% 0.560905443 57198, 10560, 2167, 6291, 3949, 350, 3043, 245973, 10242, 7220, 3772, GOTERM_MF_ALL GO:0005261~cation channel activity 3 2.26% 0.604259447 10242, 7220, 3772, GOTERM_BP_ALL GO:0030001~metal ion transport 4 3.01% 0.639428124 10242, 57685, 7220, 3772, GOTERM_MF_ALL GO:0022836~gated channel activity 3 2.26% 0.676130906 10242, 7220, 3772, SP_PIR_KEYWORDS Ionic channel 3 2.26% 0.681344739 10242, 7220, 3772, GOTERM_BP_ALL GO:0015672~monovalent inorganic cation transport 3 2.26% 0.706154021 245973, 10242, 3772, GOTERM_MF_ALL GO:0046873~metal ion transmembrane transporter activity 3 2.26% 0.709844031 10242, 7220, 3772, GOTERM_BP_ALL GO:0051234~establishment of localization 19 14.29% 0.761882704 1308, 4053, 10560, 10332, 11117, 1991, 245973, 81575, 667, 7220, 7097, 3772, 57198, 2167, 3624, 3949, 3043, 10242, 57685, GOTERM_MF_ALL GO:0022891~substrate-specific transmembrane transporter activity 6 4.51% 0.77058118 57198, 10560, 245973, 10242, 7220, 3772, GOTERM_MF_ALL GO:0005216~ion channel activity 3 2.26% 0.783774944 10242, 7220, 3772, GOTERM_MF_ALL GO:0008324~cation transmembrane transporter activity 4 3.01% 0.785733712 245973, 10242, 7220, 3772, GOTERM_BP_ALL GO:0006810~transport 18 13.53% 0.785756689 1308, 4053, 10560, 10332, 11117, 1991, 245973, 81575, 667, 7220, 7097, 3772, 57198, 2167, 3949, 3043, 10242, 57685, GOTERM_MF_ALL GO:0022838~substrate specific channel activity 3 2.26% 0.795308792 10242, 7220, 3772, GOTERM_MF_ALL GO:0015075~ion transmembrane transporter activity 5 3.76% 0.802460237 57198, 245973, 10242, 7220, 3772, GOTERM_MF_ALL GO:0015267~channel activity 3 2.26% 0.824291281 10242, 7220, 3772, GOTERM_MF_ALL GO:0022803~passive transmembrane transporter activity 3 2.26% 0.824291281 10242, 7220, 3772, GOTERM_MF_ALL GO:0022857~transmembrane transporter activity 6 4.51% 0.845339207 57198, 10560, 245973, 10242, 7220, 3772, SP_PIR_KEYWORDS transport 9 6.77% 0.865153175 10560, 2167, 3949, 3043, 245973, 10242, 57685, 7220, 3772,

Functional Group 41 Median: 0.6356446665695414 Geo: 0.5839371048006128 2176, 5371, 8626, 3159, 942, 23405, 5896, 1490, 10361, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0006461~protein complex assembly 4 3.01% 0.439104407 2176, 5371, 8626, 3159, GOTERM_MF_ALL GO:0016563~transcription activator activity 4 3.01% 0.490237259 5371, 8626, 3159, 942, GOTERM_BP_ALL GO:0065003~macromolecular complex assembly 5 3.76% 0.635644667 2176, 5371, 8626, 23405, 3159, GOTERM_BP_ALL GO:0022607~cellular component assembly 5 3.76% 0.687202543 2176, 5371, 8626, 23405, 3159, GOTERM_BP_ALL GO:0006259~DNA metabolic process 6 4.51% 0.722033064 2176, 5371, 5896, 3159, 1490, 10361,

Functional Group 42 Median: 0.7830463557995713 Geo: 0.594867979276467 1308, 2572, 4680, 1825, 10332, 8434, 2709, 7097, 54210, 10242, 2152, 3909, 56963, 2191, 84951, 81575, 1490, 667, 942, 2357, 7220, 3772, 5239, 5100, 3949, 5743, 25960, 3598, 10560, 57198, 79586, 7367, 1755, 245973, 81671, 79838, 81833, 9911, 9043, 2192, 57685, 158326, 6347, 25975, 79870, 2487, Category Term Count % PValue Genes GOTERM_CC_ALL GO:0005886~plasma membrane 27 20.30% 0.170510334 1308, 2572, 4680, 1825, 10332, 8434, 2709, 7097, 54210, 10242, 2152, 3909, 56963, 2191, 84951, 81575, 1490, 667, 942, 2357, 7220, 3772, 5239, 5100, 3949, 5743, 25960, UP_SEQ_FEATURE topological domain:Extracellular 18 13.53% 0.212072895 1308, 3598, 10560, 1825, 2191, 2709, 2357, 942, 7220, 7097, 3772, 5100, 57198, 3949, 54210, 25960, 10242, 2152, UP_SEQ_FEATURE topological domain:Cytoplasmic 19 14.29% 0.508617198 1308, 79586, 3598, 10560, 1825, 2191, 2709, 2357, 942, 7220, 7097, 3772, 5100, 57198, 3949, 54210, 25960, 10242, 2152, GOTERM_CC_ALL GO:0044425~membrane part 38 28.57% 0.759557329 1308, 2572, 10560, 10332, 1825, 4680, 7367, 2709, 1755, 245973, 7097, 57198, 81671, 54210, 10242, 79838, 2152, 81833, 3909, 9911, 79586, 3598, 2191, 84951, 81575, 667, 2357, 942, 7220, 3772, 5239, 5100, 9043, 3949, 5743, 2192, 25960, 57685, GOTERM_CC_ALL GO:0016020~membrane 46 34.59% 0.770953651 1308, 2572, 10560, 10332, 1825, 4680, 7367, 8434, 2709, 1755, 245973, 7097, 57198, 81671, 54210, 10242, 79838, 158326, 2152, 81833, 3909, 9911, 6347, 79586, 3598, 25975, 56963, 2191, 84951, 667, 81575, 1490, 2357, 942, 7220, 3772, 79870, 5239, 5100, 2487, 9043, 3949, 5743, 2192, 25960, 57685, UP_SEQ_FEATURE transmembrane region 21 15.79% 0.795139061 1308, 79586, 3598, 10560, 1825, 7367, 2191, 2709, 2357, 942, 7220, 7097, 3772, 5100, 57198, 3949, 54210, 25960, 10242, 2152, 9911, SP_PIR_KEYWORDS transmembrane 25 18.80% 0.856824881 1308, 10560, 1825, 10332, 7367, 2709, 7097, 57198, 54210, 10242, 2152, 81833, 9911, 79586, 3598, 2191, 81575, 942, 2357, 7220, 3772, 5100, 3949, 25960, 57685, GOTERM_CC_ALL GO:0016021~integral to membrane 30 22.56% 0.901197833 1308, 10560, 4680, 1825, 10332, 7367, 2709, 7097, 57198, 81671, 54210, 10242, 79838, 2152, 81833, 9911, 79586, 3598, 2191, 81575, 2357, 942, 7220, 3772, 5100, 9043, 3949, 2192, 25960, 57685, GOTERM_CC_ALL GO:0031224~intrinsic to membrane 30 22.56% 0.907020059 1308, 10560, 4680, 1825, 10332, 7367, 2709, 7097, 57198, 81671, 54210, 10242, 79838, 2152, 81833, 9911, 79586, 3598, 2191, 81575, 2357, 942, 7220, 3772, 5100, 9043, 3949, 2192, 25960, 57685, SP_PIR_KEYWORDS membrane 31 23.31% 0.925162445 1308, 2572, 10560, 4680, 1825, 10332, 7367, 8434, 2709, 7097, 57198, 54210, 10242, 2152, 81833, 9911, 79586, 3598, 56963, 2191, 81575, 2357, 942, 7220, 3772, 79870, 5100, 3949, 5743, 25960, 57685,

Functional Group 43 Median: 0.5719469394909711 Geo: 0.6067836825466483 10332, 1991, 3949, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0006897~endocytosis 3 2.26% 0.467004979 10332, 1991, 3949, GOTERM_BP_ALL GO:0010324~membrane invagination 3 2.26% 0.467004979 10332, 1991, 3949, GOTERM_BP_ALL GO:0016044~membrane organization and biogenesis 3 2.26% 0.6768889 10332, 1991, 3949, GOTERM_BP_ALL GO:0016192~vesicle-mediated transport 3 2.26% 0.918280072 10332, 1991, 3949,

Functional Group 44 Median: 0.5923665508251088 Geo: 0.6526203654390588 2167, 1991, 2357, 22870, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0045859~regulation of protein kinase activity 3 2.26% 0.565060125 2167, 1991, 2357, GOTERM_BP_ALL GO:0043549~regulation of kinase activity 3 2.26% 0.580112725 2167, 1991, 2357, GOTERM_BP_ALL GO:0051338~regulation of transferase activity 3 2.26% 0.592366551 2167, 1991, 2357, GOTERM_BP_ALL GO:0050790~regulation of catalytic activity 4 3.01% 0.742542085 2167, 1991, 2357, 22870, GOTERM_BP_ALL GO:0065009~regulation of a molecular function 4 3.01% 0.821078078 2167, 1991, 2357, 22870,

Functional Group 45 Median: 0.9477903564785138 Geo: 0.6949321152003585 9705, 116039, 1825, 10332, 23213, 164633, 3620, 8404, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 124, 3772, 244, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, 79586, 5239, 57198, 3899, 1820, 3159, 5307, 10481, 23405, 8771, 10361, 29974, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0043169~cation binding 36 27.07% 0.106669537 9705, 116039, 1825, 10332, 23213, 164633, 3620, 8404, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 124, 3772, 244, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, SP_PIR_KEYWORDS metal-binding 20 15.04% 0.589617518 9705, 79586, 5371, 116039, 10332, 8626, 23213, 3620, 3658, 124, 5239, 57198, 8013, 79413, 5743, 3043, 349075, 5896, 158326, 1959, SP_PIR_KEYWORDS dna-binding 12 9.02% 0.757574611 9705, 3899, 5371, 8013, 8626, 1820, 349075, 5896, 3159, 5307, 10481, 1959, GOTERM_MF_ALL GO:0003676~nucleic acid binding 20 15.04% 0.946691376 9705, 5371, 116039, 8626, 23405, 8771, 1820, 10361, 10481, 3658, 3899, 8013, 29974, 79413, 349075, 3159, 5896, 25976, 5307, 1959, GOTERM_MF_ALL GO:0003677~DNA binding 13 9.77% 0.947790356 9705, 5371, 8626, 1820, 10481, 3899, 8013, 79413, 349075, 3159, 5896, 5307, 1959, SP_PIR_KEYWORDS zinc-finger 8 6.02% 0.958582097 9705, 5371, 8013, 116039, 79413, 349075, 5896, 1959, SP_PIR_KEYWORDS zinc 10 7.52% 0.967716873 9705, 5371, 8013, 116039, 8626, 79413, 349075, 5896, 1959, 124, GOTERM_MF_ALL GO:0046914~transition metal ion binding 15 11.28% 0.968429142 9705, 5371, 116039, 8626, 3620, 3658, 124, 8013, 79413, 3043, 5743, 349075, 5896, 25976, 1959, GOTERM_MF_ALL GO:0008270~zinc ion binding 11 8.27% 0.984190253 9705, 5371, 8013, 116039, 8626, 79413, 349075, 5896, 25976, 1959, 124,

Functional Group 46 Median: 0.7097876655479984 Geo: 0.7039383878430636 57198, 5340, 1513, 23213, 23405, 1991, 2191, 5209, 5408, 245973, 5896, 2070, 8771, 5239, 827, 2572, 7367, 5187, 3620, 7097, 6347, 79586, 3658, 124, 5157, 5743, 3067, 25976, Category Term Count % PValue Genes SP_PIR_KEYWORDS hydrolase 12 9.02% 0.50173462 57198, 5340, 1513, 23213, 23405, 1991, 2191, 5209, 5408, 245973, 5896, 2070, GOTERM_MF_ALL GO:0016788~hydrolase activity, acting on ester bonds 6 4.51% 0.592523796 23213, 23405, 5209, 5408, 5896, 2070, GOTERM_MF_ALL GO:0016787~hydrolase activity 15 11.28% 0.827051536 23405, 23213, 8771, 5209, 2191, 1991, 5408, 245973, 2070, 5239, 5340, 57198, 1513, 5896, 827, GOTERM_MF_ALL GO:0003824~catalytic activity 28 21.05% 0.998679557 2572, 23213, 7367, 5209, 245973, 5187, 3620, 7097, 5340, 57198, 5896, 827, 6347, 79586, 23405, 8771, 2191, 1991, 5408, 3658, 2070, 124, 5239, 5157, 1513, 5743, 3067, 25976,

Functional Group 47 Median: 0.7220330639908624 Geo: 0.7514084898141556 5371, 3159, 10361, 2176, 5896, 1490, 2919, 286887, 667, 29974, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0016568~chromatin modification 3 2.26% 0.495530567 5371, 3159, 10361, GOTERM_BP_ALL GO:0006325~establishment and/or maintenance of chromatin architecture 3 2.26% 0.692777759 5371, 3159, 10361, GOTERM_BP_ALL GO:0006323~DNA packaging 3 2.26% 0.704272874 5371, 3159, 10361, GOTERM_BP_ALL GO:0006259~DNA metabolic process 6 4.51% 0.722033064 2176, 5371, 5896, 3159, 1490, 10361, GOTERM_BP_ALL GO:0051276~chromosome organization and biogenesis 3 2.26% 0.811248771 5371, 3159, 10361, GOTERM_BP_ALL GO:0006996~organelle organization and biogenesis 6 4.51% 0.961215948 2919, 5371, 286887, 3159, 667, 10361, GOTERM_CC_ALL GO:0044428~nuclear part 4 3.01% 0.993562592 5371, 29974, 3159, 10361,

Functional Group 48 Median: 0.795678224923611 Geo: 0.7785121282224401 2572, 3067, 3620, 3043, 5743, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0006520~amino acid metabolic process 3 2.26% 0.6768889 2572, 3067, 3620, GOTERM_BP_ALL GO:0006807~nitrogen compound metabolic process 4 3.01% 0.733956758 2572, 3043, 3067, 3620, GOTERM_BP_ALL GO:0006519~amino acid and derivative metabolic process 3 2.26% 0.781050486 2572, 3067, 3620, GOTERM_BP_ALL GO:0019752~carboxylic acid metabolic process 4 3.01% 0.810305964 2572, 5743, 3067, 3620, GOTERM_BP_ALL GO:0006082~organic acid metabolic process 4 3.01% 0.813592917 2572, 5743, 3067, 3620, GOTERM_BP_ALL GO:0009308~amine metabolic process 3 2.26% 0.870300291 2572, 3067, 3620,

Functional Group 49 Median: 0.8618304170813864 Geo: 0.7953775339037139 3899, 5371, 8626, 5307, 2070, 1959, 9705, 8013, 1820, 3159, 10481, 5187, 8864, 349075, 3553, 23405, 1991, 942, 2167, 3624, 5896, 3043, 245973, 10361, 2176, 8771, 1490, 29974, 116039, 3658, 79413, 25976, 219539, 2572, 23213, 7367, 5209, 3620, 5340, 827, 6347, 2191, 5408, 81575, 124, 5239, 1513, 3949, 5743, 3067, 7097, 57198, Category Term Count % PValue Genes SP_PIR_KEYWORDS activator 6 4.51% 0.270473699 3899, 5371, 8626, 5307, 2070, 1959, GOTERM_MF_ALL GO:0003700~transcription factor activity 9 6.77% 0.469572293 9705, 5371, 8013, 8626, 1820, 3159, 5307, 10481, 1959, SP_PIR_KEYWORDS Transcription regulation 14 10.53% 0.60098649 9705, 5371, 8626, 1820, 5187, 2070, 10481, 3899, 8013, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0010468~regulation of gene expression 20 15.04% 0.613558096 9705, 5371, 3553, 8626, 23405, 1991, 1820, 5187, 942, 10481, 2070, 3899, 8013, 2167, 3624, 8864, 349075, 3159, 5307, 1959, SP_PIR_KEYWORDS Transcription 14 10.53% 0.631634693 9705, 5371, 8626, 1820, 5187, 2070, 10481, 3899, 8013, 8864, 349075, 3159, 5307, 1959, GOTERM_MF_ALL GO:0030528~transcription regulator activity 11 8.27% 0.692593557 9705, 5371, 8013, 8626, 2167, 1820, 3159, 942, 5307, 10481, 1959, SP_PIR_KEYWORDS dna-binding 12 9.02% 0.757574611 9705, 3899, 5371, 8013, 8626, 1820, 349075, 5896, 3159, 5307, 10481, 1959, GOTERM_MF_ALL GO:0043565~sequence-specific DNA binding 4 3.01% 0.761025852 8013, 3159, 5307, 10481, GOTERM_BP_ALL GO:0019222~regulation of metabolic process 20 15.04% 0.764404213 9705, 5371, 3553, 8626, 1991, 1820, 5187, 942, 10481, 2070, 3899, 8013, 2167, 3624, 8864, 3043, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0045449~regulation of transcription 17 12.78% 0.775675436 9705, 5371, 8626, 1820, 5187, 942, 2070, 10481, 3899, 8013, 2167, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0031323~regulation of cellular metabolic process 19 14.29% 0.782527974 9705, 5371, 3553, 8626, 1991, 1820, 5187, 942, 2070, 10481, 3899, 8013, 2167, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0019219~regulation of nucleobase, nucleoside, nucleotide and nucleic acid17 metabolic12.78% process0.812666241 9705, 5371, 8626, 1820, 5187, 942, 2070, 10481, 3899, 8013, 2167, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0006350~transcription 17 12.78% 0.82643549 9705, 5371, 8626, 1820, 5187, 942, 2070, 10481, 3899, 8013, 2167, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0006355~regulation of transcription, DNA-dependent 15 11.28% 0.849518252 9705, 5371, 8626, 1820, 5187, 2070, 10481, 3899, 8013, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0006351~transcription, DNA-dependent 15 11.28% 0.874142582 9705, 5371, 8626, 1820, 5187, 2070, 10481, 3899, 8013, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0032774~RNA biosynthetic process 15 11.28% 0.875515805 9705, 5371, 8626, 1820, 5187, 2070, 10481, 3899, 8013, 3624, 8864, 349075, 3159, 5307, 1959, GOTERM_BP_ALL GO:0006139~nucleobase, nucleoside, nucleotide and nucleic acid metabolic process25 18.80% 0.879378094 9705, 1820, 245973, 5187, 10361, 349075, 5896, 3159, 1959, 2176, 5371, 23405, 8626, 8771, 1490, 942, 2070, 10481, 3899, 8013, 2167, 29974, 3624, 8864, 5307, GOTERM_BP_ALL GO:0010467~gene expression 21 15.79% 0.934518296 9705, 5371, 3553, 8626, 23405, 1991, 1820, 5187, 942, 10481, 2070, 3899, 8013, 2167, 3624, 29974, 8864, 349075, 3159, 5307, 1959, GOTERM_MF_ALL GO:0003676~nucleic acid binding 20 15.04% 0.946691376 9705, 5371, 116039, 8626, 23405, 8771, 1820, 10361, 10481, 3658, 3899, 8013, 29974, 79413, 349075, 3159, 5896, 25976, 5307, 1959, GOTERM_MF_ALL GO:0003677~DNA binding 13 9.77% 0.947790356 9705, 5371, 8626, 1820, 10481, 3899, 8013, 79413, 349075, 3159, 5896, 5307, 1959, GOTERM_BP_ALL GO:0016070~RNA metabolic process 17 12.78% 0.94846823 9705, 5371, 8626, 23405, 1820, 5187, 2070, 10481, 3899, 8013, 3624, 29974, 8864, 349075, 3159, 5307, 1959, SP_PIR_KEYWORDS nucleus 20 15.04% 0.988871836 9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, GOTERM_BP_ALL GO:0044237~cellular metabolic process 46 34.59% 0.996747006 9705, 2572, 3553, 23213, 7367, 5209, 1820, 245973, 5187, 3620, 10361, 5340, 349075, 5896, 3159, 827, 1959, 6347, 2176, 5371, 8626, 23405, 8771, 1991, 2191, 5408, 81575, 1490, 942, 10481, 2070, 124, 3899, 5239, 1513, 8013, 2167, 3624, 29974, 8864, 3949, 5743, 3043, 3067, 25976, 5307, GOTERM_CC_ALL GO:0005634~nucleus 22 16.54% 0.999241188 9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 5743, 349075, 3159, 5896, 25976, 5307, 219539, 1959, GOTERM_BP_ALL GO:0044238~primary metabolic process 44 33.08% 0.999291596 9705, 2572, 3553, 23213, 7367, 5209, 1820, 245973, 5187, 3620, 10361, 5340, 349075, 5896, 3159, 827, 1959, 6347, 2176, 5371, 8626, 23405, 8771, 1991, 2191, 5408, 81575, 1490, 942, 10481, 2070, 3899, 5239, 1513, 8013, 2167, 3624, 29974, 8864, 3949, 5743, 3067, 25976, 5307, GOTERM_BP_ALL GO:0043283~biopolymer metabolic process 25 18.80% 0.999338344 9705, 1820, 5187, 10361, 349075, 5896, 3159, 1959, 6347, 2176, 5371, 23405, 8626, 1991, 1490, 2070, 10481, 3899, 8013, 29974, 3624, 3949, 8864, 25976, 5307, GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 36 27.07% 0.999519544 9705, 2572, 3553, 23213, 5209, 1820, 5187, 10361, 5340, 349075, 5896, 3159, 827, 1959, 6347, 2176, 5371, 8626, 23405, 1991, 2191, 81575, 1490, 942, 10481, 2070, 3899, 5239, 1513, 8013, 3624, 29974, 8864, 3949, 25976, 5307, GOTERM_BP_ALL GO:0008152~metabolic process 49 36.84% 0.999526623 9705, 3553, 23213, 7367, 245973, 5187, 7097, 5340, 57198, 349075, 3159, 5896, 2176, 5371, 1991, 5408, 10481, 124, 8013, 29974, 3949, 8864, 3043, 5743, 3067, 5307, 2572, 5209, 1820, 10361, 3620, 827, 1959, 6347, 23405, 8626, 8771, 2191, 1490, 81575, 942, 3658, 2070, 5239, 3899, 1513, 2167, 3624, 25976,

Functional Group 50 Median: 0.9970965406190869 Geo: 0.9367985752146062 57198, 23405, 8771, 245973, 5209, 29974, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0042623~ATPase activity, coupled 3 2.26% 0.657044227 57198, 23405, 8771, GOTERM_MF_ALL GO:0016887~ATPase activity 3 2.26% 0.752449514 57198, 23405, 8771, GOTERM_MF_ALL GO:0016817~hydrolase activity, acting on acid anhydrides 4 3.01% 0.87662346 57198, 23405, 8771, 245973, GOTERM_MF_ALL GO:0017111~nucleoside-triphosphatase activity 3 2.26% 0.949967734 57198, 23405, 8771, GOTERM_MF_ALL GO:0016462~pyrophosphatase activity 3 2.26% 0.959424891 57198, 23405, 8771, GOTERM_MF_ALL GO:0016818~hydrolase activity, acting on acid anhydrides, in phosphorus-containing3 anhydrides2.26% 0.96036415 57198, 23405, 8771, GOTERM_MF_ALL GO:0005524~ATP binding 5 3.76% 0.996748879 57198, 23405, 8771, 5209, 245973, GOTERM_MF_ALL GO:0032559~adenyl ribonucleotide binding 5 3.76% 0.997096541 57198, 23405, 8771, 5209, 245973, GOTERM_MF_ALL GO:0030554~adenyl nucleotide binding 5 3.76% 0.998299248 57198, 23405, 8771, 5209, 245973, SP_PIR_KEYWORDS atp-binding 3 2.26% 0.998882289 57198, 23405, 5209, GOTERM_MF_ALL GO:0032553~ribonucleotide binding 5 3.76% 0.999682212 57198, 23405, 8771, 5209, 245973, GOTERM_MF_ALL GO:0032555~purine ribonucleotide binding 5 3.76% 0.999682212 57198, 23405, 8771, 5209, 245973, GOTERM_MF_ALL GO:0017076~purine nucleotide binding 5 3.76% 0.9998244 57198, 23405, 8771, 5209, 245973, GOTERM_MF_ALL GO:0000166~nucleotide binding 6 4.51% 0.999883615 57198, 23405, 29974, 8771, 5209, 245973, SP_PIR_KEYWORDS nucleotide-binding 3 2.26% 0.999901807 57198, 23405, 5209,

Functional Group 51 Median: 0.9761307898572631 Geo: 0.9727745750833203 6347, 5157, 5209, 5187, 79586, 7367, 25976, Category Term Count % PValue Genes GOTERM_MF_ALL GO:0016773~phosphotransferase activity, alcohol group as acceptor 4 3.01% 0.938391748 6347, 5157, 5209, 5187, GOTERM_MF_ALL GO:0004672~protein kinase activity 3 2.26% 0.962768914 6347, 5157, 5187, GOTERM_MF_ALL GO:0016301~kinase activity 4 3.01% 0.97613079 6347, 5157, 5209, 5187, GOTERM_MF_ALL GO:0016772~transferase activity, transferring phosphorus-containing groups 4 3.01% 0.990578881 6347, 5157, 5209, 5187, GOTERM_MF_ALL GO:0016740~transferase activity 7 5.26% 0.997143678 6347, 79586, 5157, 7367, 5209, 5187, 25976,

Functional Group 52 Median: 0.9871374477702024 Geo: 0.9884132351696798 6347, 2176, 5371, 3553, 8626, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, 9705, 2572, 5209, 1820, 5187, 10361, 349075, 5896, 1959, 23405, 1490, 10481, 2070, 3899, 8013, 8864, 5307, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0019538~protein metabolic process 19 14.29% 0.979960539 6347, 2176, 5371, 3553, 8626, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, GOTERM_BP_ALL GO:0044267~cellular protein metabolic process 17 12.78% 0.985696852 6347, 5371, 3553, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, GOTERM_BP_ALL GO:0044260~cellular macromolecule metabolic process 17 12.78% 0.988578044 6347, 5371, 3553, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 36 27.07% 0.999519544 9705, 2572, 3553, 23213, 5209, 1820, 5187, 10361, 5340, 349075, 5896, 3159, 827, 1959, 6347, 2176, 5371, 8626, 23405, 1991, 2191, 81575, 1490, 942, 10481, 2070, 3899, 5239, 1513, 8013, 3624, 29974, 8864, 3949, 25976, 5307,

Functional Group 53 Median: 0.9933358310738967 Geo: 0.9885228103128756 4053, 10332, 667, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0046907~intracellular transport 3 2.26% 0.97801451 4053, 10332, 667, GOTERM_BP_ALL GO:0051649~establishment of cellular localization 3 2.26% 0.993335831 4053, 10332, 667, GOTERM_BP_ALL GO:0051641~cellular localization 3 2.26% 0.994302854 4053, 10332, 667,

Functional Group 54 Median: 0.996178591718086 Geo: 0.9932159458342067 6347, 3624, 245973, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0016310~phosphorylation 3 2.26% 0.987317061 6347, 3624, 245973, GOTERM_BP_ALL GO:0006796~phosphate metabolic process 3 2.26% 0.996178592 6347, 3624, 245973, GOTERM_BP_ALL GO:0006793~phosphorus metabolic process 3 2.26% 0.996178592 6347, 3624, 245973,

Functional Group 55 Median: 0.9998017491618408 Geo: 0.9986909808272089 9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, 79586, 2572, 9547, 23213, 7367, 1755, 667, 2357, 4969, 1513, 9043, 3949, 5743, 81671, 3043, 25976, 6347, 23405, 1991, 1490, 3624, 1308, 10332, 11117, 84951, 22870, 3658, 124, 79870, 2167, 1825, 81851, 3853, 83957, 286887, 3854, 3853, 3861, 3885, 827, 10560, 8434, 245973, 7097, 57198, 54210, 10242, 2152, 3909, 9911, 25975, 3772, 2192, 25960, 57685, 4680, 2709, 79838, 158326, 81833, 3598, 56963, 8771, 2191, 81575, 942, 7220, 5239, 5100, 2487, Category Term Count % PValue Genes SP_PIR_KEYWORDS nucleus 20 15.04% 0.988871836 9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, GOTERM_CC_ALL GO:0044444~cytoplasmic part 18 13.53% 0.99628473 79586, 2176, 2572, 9547, 23213, 7367, 1755, 667, 2357, 10361, 4969, 1513, 9043, 29974, 3949, 5743, 81671, 3043, GOTERM_CC_ALL GO:0005634~nucleus 22 16.54% 0.999241188 9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 5743, 349075, 3159, 5896, 25976, 5307, 219539, 1959, GOTERM_BP_ALL GO:0043283~biopolymer metabolic process 25 18.80% 0.999338344 9705, 1820, 5187, 10361, 349075, 5896, 3159, 1959, 6347, 2176, 5371, 23405, 8626, 1991, 1490, 2070, 10481, 3899, 8013, 29974, 3624, 3949, 8864, 25976, 5307, GOTERM_CC_ALL GO:0005737~cytoplasm 32 24.06% 0.999745261 1308, 9547, 2572, 10332, 23213, 11117, 7367, 1755, 1820, 5187, 10361, 4969, 81671, 79586, 2176, 5371, 84951, 667, 2357, 22870, 3658, 2070, 124, 79870, 1513, 9043, 2167, 29974, 8864, 3949, 5743, 3043, GOTERM_CC_ALL GO:0043229~intracellular organelle 45 33.83% 0.999796468 9705, 9547, 2572, 1825, 116039, 23213, 7367, 81851, 1755, 1820, 5187, 10361, 4969, 3853, 81671, 349075, 5896, 3159, 219539, 1959, 79586, 2176, 5371, 8626, 84951, 667, 2357, 10481, 2070, 3899, 83957, 1513, 286887, 8013, 9043, 29974, 3854, 3853, 8864, 3949, 3861, 5743, 25976, 3885, 5307, GOTERM_CC_ALL GO:0043226~organelle 45 33.83% 0.999801749 9705, 9547, 2572, 1825, 116039, 23213, 7367, 81851, 1755, 1820, 5187, 10361, 4969, 3853, 81671, 349075, 5896, 3159, 219539, 1959, 79586, 2176, 5371, 8626, 84951, 667, 2357, 10481, 2070, 3899, 83957, 1513, 286887, 8013, 9043, 29974, 3854, 3853, 8864, 3949, 3861, 5743, 25976, 3885, 5307, GOTERM_CC_ALL GO:0043231~intracellular membrane-bound organelle 35 26.32% 0.999985063 9705, 9547, 2572, 116039, 23213, 7367, 1755, 1820, 5187, 10361, 4969, 81671, 349075, 5896, 3159, 219539, 1959, 79586, 2176, 5371, 8626, 667, 2357, 2070, 10481, 3899, 1513, 8013, 9043, 29974, 8864, 3949, 5743, 25976, 5307, GOTERM_CC_ALL GO:0043227~membrane-bound organelle 35 26.32% 0.999985392 9705, 9547, 2572, 116039, 23213, 7367, 1755, 1820, 5187, 10361, 4969, 81671, 349075, 5896, 3159, 219539, 1959, 79586, 2176, 5371, 8626, 667, 2357, 2070, 10481, 3899, 1513, 8013, 9043, 29974, 8864, 3949, 5743, 25976, 5307, GOTERM_CC_ALL GO:0044424~intracellular part 54 40.60% 0.999992698 9705, 1308, 116039, 1825, 10332, 23213, 7367, 81851, 5187, 81671, 349075, 3159, 5896, 219539, 2176, 5371, 22870, 10481, 124, 286887, 8013, 9043, 29974, 3949, 8864, 3043, 5743, 5307, 9547, 2572, 11117, 1820, 1755, 10361, 4969, 3853, 1959, 79586, 8626, 84951, 667, 2357, 3658, 2070, 79870, 3899, 83957, 1513, 2167, 3854, 3853, 3861, 25976, 3885, GOTERM_CC_ALL GO:0005622~intracellular 56 42.11% 0.999998762 9705, 1308, 116039, 1825, 10332, 23213, 7367, 81851, 5187, 81671, 349075, 3159, 5896, 219539, 2176, 5371, 22870, 10481, 124, 286887, 8013, 9043, 29974, 3949, 8864, 3043, 5743, 5307, 9547, 2572, 11117, 1820, 1755, 10361, 4969, 3853, 827, 1959, 79586, 8626, 23405, 84951, 667, 2357, 3658, 2070, 79870, 3899, 83957, 1513, 2167, 3854, 3853, 3861, 25976, 3885, GOTERM_CC_ALL GO:0044464~cell part 89 66.92% 0.999999996 9705, 1308, 10560, 10332, 1825, 116039, 23213, 7367, 8434, 81851, 245973, 5187, 7097, 57198, 54210, 81671, 349075, 10242, 3159, 5896, 2152, 3909, 9911, 219539, 2176, 5371, 25975, 1991, 22870, 10481, 124, 3772, 286887, 8013, 9043, 29974, 8864, 3949, 5743, 3043, 2192, 25960, 57685, 5307, 2572, 9547, 4680, 11117, 2709, 1755, 1820, 10361, 4969, 3853, 79838, 158326, 827, 81833, 1959, 6347, 79586, 3598, 56963, 8626, 23405, 8771, 2191, 84951, 81575, 1490, 667, 2357, 942, 7220, 3658, 2070, 79870, 3899, 5239, 5100, 83957, 1513, 2487, 2167, 3853, 3854, 3861, 25976, 3885, GOTERM_CC_ALL GO:0005623~cell 89 66.92% 0.999999997 9705, 1308, 10560, 10332, 1825, 116039, 23213, 7367, 8434, 81851, 245973, 5187, 7097, 57198, 54210, 81671, 349075, 10242, 3159, 5896, 2152, 3909, 9911, 219539, 2176, 5371, 25975, 1991, 22870, 10481, 124, 3772, 286887, 8013, 9043, 29974, 8864, 3949, 5743, 3043, 2192, 25960, 57685, 5307, 2572, 9547, 4680, 11117, 2709, 1755, 1820, 10361, 4969, 3853, 79838, 158326, 827, 81833, 1959, 6347, 79586, 3598, 56963, 8626, 23405, 8771, 2191, 84951, 81575, 1490, 667, 2357, 942, 7220, 3658, 2070, 79870, 3899, 5239, 5100, 83957, 1513, 2487, 2167, 3853, 3854, 3861, 25976, 3885,

Functional Group 56 Median: 0.9999333826422183 Geo: 0.9998921651552436 6347, 5371, 29974, 3949, 25976, Category Term Count % PValue Genes GOTERM_BP_ALL GO:0043412~biopolymer modification 5 3.76% 0.999803635 6347, 5371, 29974, 3949, 25976, GOTERM_BP_ALL GO:0043687~post-translational protein modification 3 2.26% 0.999933383 6347, 5371, 25976, GOTERM_BP_ALL GO:0006464~protein modification process 4 3.01% 0.999939484 6347, 5371, 3949, 25976, 1308, 9547, 3553, 23213, 6291, 11117, 81851, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 158326, 7057, 3909, 6347, 3512, 4053, 3598, 25975, 1991, 168667, 4060, 5408, 2202, 1490, 81575, 667, 3491, 2919, 6279, 2487, 3624, 3918, 350, 2192, 4838, 1825, 7367, 8434, 7097, 54210, 2152, 25890, 5268, 3949, 5743, 25960, 57685, 4680, 81833, 56963, 8771, 84951, 942, 5100, 1513, 5157, 10560, 10332, 10242, 3043, 79586, 2191, 2357, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 1052 12300 4.145350847 1.01E-11 1.01E-11 1.82E-11 119 2409 13496 2.49515298 3.33E-08 3.33E-08 5.11E-08 110 707 12300 4.428442844 5.31E-08 2.66E-08 9.58E-08 119 2965 13496 2.218510068 2.20E-07 1.10E-07 3.38E-07 119 1216 13496 3.264318885 5.26E-07 1.75E-07 8.08E-07 96 2041 10303 2.418840846 1.94E-05 1.94E-05 2.47E-06 96 2387 10303 2.158148303 2.94E-04 1.47E-04 3.75E-05 96 1711 10303 2.383559809 0.002462148 8.21E-04 3.15E-04

1308, 10560, 116039, 3553, 8434, 7097, 1440, 5340, 10242, 5896, 7057, 2152, 3909, 5371, 25975, 4060, 1991, 5408, 10481, 3491, 8013, 3918, 3949, 3043, 5743, 5307, 2572, 2709, 10361, 7980, 3853, 158326, 1959, 6347, 56963, 23405, 8626, 2202, 1490, 81575, 942, 2070, 244, 2919, 3899, 5100, 2487, 2167, 3624, 3853, 3854, 3861, 350, 4838, 3885, 1755, 23213, 8771, 84951, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 2976 11642 2.088911943 1.48E-05 1.48E-05 5.48E-06 103 1164 11642 3.10732993 4.28E-05 1.07E-05 1.59E-05 103 2078 11642 2.284515544 4.65E-04 7.75E-05 1.73E-04 103 1927 11642 2.287564049 0.001846334 2.64E-04 6.86E-04 103 1583 11642 2.42766285 0.004481097 4.99E-04 0.00166678 103 2905 11642 1.828698428 0.035525753 0.003009807 0.013423567 103 1012 11642 2.457154918 0.542604504 0.044969658 0.289877286 103 1654 11642 1.845094563 0.999890548 0.223791364 3.328048439 103 1654 11642 1.845094563 0.999890548 0.223791364 3.328048439

1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 707 12300 4.428442844 5.31E-08 2.66E-08 9.58E-08 110 292 12300 5.361145704 0.001521413 3.81E-04 0.002746174 110 297 12300 5.270890725 0.001836915 3.68E-04 0.003316175 119 195 13496 6.397586727 0.008170182 0.002048834 0.01258809 110 95 12300 7.062200957 0.732519085 0.15196925 2.350445081 119 28 13496 16.20168067 0.847936991 0.157366915 2.848857855 110 63 12300 8.874458874 0.864742848 0.199313975 3.544050111

1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, 6291, 1991, 5187, 2357, 3491, 10481, 7097, 244, 2167, 350, 5743, 2152, 1959, 5371, 8626, 3658, 29974, 3949, 3043, 10242, 5408, 1755, 10332, 3620, 54210, 5896, 2176, 3512, 23405, 942, 3159, 8771, 84951, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 707 12300 4.428442844 5.31E-08 2.66E-08 9.58E-08 103 585 11642 4.443880176 2.52E-05 1.26E-05 9.35E-06 103 395 11642 5.436844046 4.12E-05 1.37E-05 1.53E-05 110 459 12300 4.385026738 4.63E-04 1.54E-04 8.36E-04 103 786 11642 3.16366511 0.017842168 0.001798706 0.006681276 103 500 11642 3.842990291 0.033150397 0.003060065 0.012510779 103 2057 11642 2.03309561 0.072501553 0.005772824 0.027928677 103 276 11642 4.914309835 0.137251863 0.009793889 0.054775422 103 965 11642 2.459701192 0.691450643 0.054455167 0.435447801 119 156 13496 5.815987934 0.362127175 0.048730026 0.687574854 103 135 11642 5.860769507 0.997673856 0.194711858 2.225214563 103 135 11642 5.860769507 0.997673856 0.194711858 2.225214563 114 156 12615 4.965418354 0.999596353 0.926096113 4.83496174 114 211 12615 4.19555999 0.999695923 0.867947704 5.005748596 103 176 11642 4.495476611 1 0.414043176 8.176275599 103 524 11642 2.588453272 1 0.493511164 10.9642118 114 672 12615 2.305372807 0.999999998 0.916597219 11.84021643 103 295 11642 3.065196643 1 0.773406985 24.91183206 119 60 13496 7.560784314 0.999999907 0.636394705 21.9947462 119 115 13496 4.930946292 0.999999995 0.653205995 25.36187327 42 234 3805 2.71011396 0.999518912 0.978066274 37.92151569 114 45 12615 7.377192982 1 0.999950877 67.77571598 114 46 12615 7.216819222 1 0.999943589 69.2319897 119 63 13496 5.400560224 1 0.98572249 82.80389243 114 69 12615 4.811212815 1 0.999999882 91.17712674 103 381 11642 0.88999312 1 1 100 103 1334 11642 0.677835839 1 1 100

5340, 5371, 8013, 3553, 23405, 1490, 81575, 7057, 3491, 8434, 6347, 116039, 8626, 4838, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 169 11642 6.019302579 0.446528214 0.03629643 0.219297452 103 179 11642 5.683028692 0.585395919 0.047735881 0.326218735 103 136 11642 6.64877213 0.617171615 0.049279521 0.355710492 103 182 11642 5.589352395 0.627248966 0.048144677 0.365575006 103 158 11642 5.722993732 0.909097726 0.095086054 0.886003662 103 383 11642 3.541382545 0.929168837 0.100483829 0.977731855 103 19 11642 17.84670414 1 0.70491792 20.26652693 103 38 11642 8.923352069 1 0.960295067 57.26388191 5239, 5100, 25975, 1825, 11117, 3918, 667, 1490, 158326, 7057, 3491, 3909, 6347, 1308, 56963, 10332, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 311 13496 4.376016645 0.086202806 0.012795521 0.138237011 103 644 11642 2.808177049 0.907960217 0.102761334 0.881429151 103 644 11642 2.808177049 0.907960217 0.102761334 0.881429151 103 217 11642 3.125229296 1 0.958643619 55.76894591

1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, 9705, 1991, 168667, 26166, 5187, 667, 2167, 349075, 3159, 2152, 22870, 29974, 3949, 8864, 2572, 1820, 7980, 4053, 2357, 3658, 244, 350, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 2905 11642 1.828698428 0.035525753 0.003009807 0.013423567 103 1043 11642 2.275754219 0.960582656 0.11694455 1.192886171 103 1085 11642 2.187660507 0.995045103 0.178455841 1.950440622 103 4454 11642 1.395734607 0.999873491 0.232008397 3.276076066 103 4044 11642 1.313642169 1 0.833825581 30.67313127 103 3738 11642 1.269990182 1 0.975468636 63.37827549

1308, 286887, 1825, 3853, 3854, 3918, 3853, 2709, 3861, 7057, 3885, 3909, 5743, 1490, 10481, 5340, 8013, 5307, 81851, 11117, 4060, 667, 7980, 5239, 2192, 83957, 84951, 5371, 10361, 3159, 2572, 1755, 29974, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 42 120 3805 9.05952381 5.53E-06 5.53E-06 3.45E-05 103 139 11642 9.757910177 1.71E-04 3.43E-05 6.36E-05 103 307 11642 5.522595743 0.00221396 2.77E-04 8.23E-04 103 127 11642 8.009938078 0.073981157 0.005475007 0.028521028 119 76 13496 10.44582043 0.052549879 0.010738127 0.082801115 60 50 5711 11.422 0.352405541 0.352405541 0.264047961 115 62 13101 11.02468443 0.67626879 0.67626879 0.383183504 119 62 13496 10.97533207 0.190220437 0.026029391 0.323251717 114 621 12615 2.851089075 0.69232697 0.445317181 0.74468103 110 110 12300 7.115702479 0.307798361 0.059471189 0.661332947 110 110 12300 7.115702479 0.307798361 0.059471189 0.661332947 115 22 13101 20.71304348 0.993011196 0.916400934 1.675373591 96 12 10303 26.83072917 1 0.999999978 10.63874714 114 80 12615 6.916118421 0.999999907 0.901040808 9.757989793 96 27 10303 11.92476852 1 1 42.45627894 96 31 10303 10.38608871 1 1 51.21296416 96 33 10303 9.756628788 1 1 55.38197804 96 33 10303 9.756628788 1 1 55.38197804 96 33 10303 9.756628788 1 1 55.38197804 96 34 10303 9.469669118 1 1 57.40091582 96 35 10303 9.199107143 1 1 59.37217348 96 37 10303 8.701858108 1 1 63.16203119 110 923 12300 1.332611051 1 0.999999908 99.6119014 110 563 12300 1.390279348 1 0.999999999 99.94225975 110 1527 12300 1.025183068 1 1 99.9999448 110 1527 12300 1.025183068 1 1 99.9999448 110 3041 12300 0.478012615 1 1 100 110 3052 12300 0.476289765 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 91 11642 7.45246986 0.997905048 0.185847427 2.263192779 103 93 11642 7.292201691 0.998885645 0.191426543 2.491898611 103 96 11642 7.064320388 0.999604092 0.211327319 2.865670484 103 113 11642 6.001546525 0.99999989 0.336862429 5.772215677 103 119 11642 5.69894754 0.999999998 0.386212198 7.158018623 119 42 13496 10.80112045 0.997647173 0.372209679 8.868971072 119 201 13496 2.821188177 1 0.984613887 81.08941644

4053, 1825, 10332, 25975, 23213, 3241, 2202, 164633, 667, 7220, 244, 8404, 5100, 5340, 6279, 3949, 2192, 57685, 158326, 7057, 9705, 116039, 245973, 3620, 57198, 79413, 349075, 5896, 1959, 79586, 5371, 8626, 3658, 2070, 124, 3772, 5239, 8013, 5743, 3043, 25976, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 788 12615 2.808576009 0.173200769 0.173200769 0.120535819 119 602 13496 3.202657807 0.068022168 0.011672385 0.108043438 114 3472 12615 1.306732052 1 0.99986314 51.97322183 114 3543 12615 1.280545776 1 0.999892624 62.66472253 114 3207 12615 1.242184038 1 0.999999474 86.69644643 119 2232 13496 1.016234451 1 0.999999993 99.99992715

3918, 350, 1490, 7057, 3491, 7097, 168667, 10332, 158326, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 56 13496 10.12605042 0.773840475 0.138130547 2.255280182 114 109 12615 6.091260261 0.999754779 0.810368112 5.135249194 115 37 13101 12.31586369 1 0.977688222 7.472619486 114 73 12615 7.579307859 0.999991522 0.857202919 7.137876217 76 37 7684 10.93029872 0.962968471 0.962968471 7.782059294 114 94 12615 5.886058231 1 0.957606724 16.50571893 96 17 10303 18.93933824 1 1 20.19151679 96 17 10303 18.93933824 1 1 20.19151679 114 98 12615 5.645810956 1 0.962448781 18.78958315 114 260 12615 2.979251012 1 0.999093891 41.32507791 115 52 13101 6.572408027 1 1 77.82206361 76 53 7684 5.722939424 1 0.99979605 76.8252365

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 96 15 10303 21.46458333 1 1 16.14011467 115 19 13101 17.98764302 1 0.99937418 20.22708422 76 19 7684 15.96398892 0.999840052 0.945717543 19.33342777

5268, 5340, 3553, 1991, 5743, 4838, 1490, 2357, 7057, 3909, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 375 11642 3.014110032 1 0.47909053 10.10233394 103 375 11642 3.014110032 1 0.47909053 10.10233394 103 238 11642 2.84947377 1 0.983273978 67.974973

4053, 25975, 3949, 3918, 5743, 2202, 2192, 7057, 3909, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 115 253 13101 4.052551985 0.99990702 0.954696778 3.11059005 115 67 13101 8.501622323 0.999999816 0.979290946 5.142274752 115 168 13101 4.74673913 0.999999997 0.980455284 6.478136458 96 37 10303 11.60247748 1 0.999999997 9.620244881 115 90 13101 6.328985507 1 0.99826803 14.05916638 115 91 13101 6.259436216 1 0.996917705 14.56877639 76 92 7684 5.494851259 0.99939437 0.975390443 16.64982756 115 173 13101 3.951042976 1 0.999955786 28.91565492 96 23 10303 13.9986413 1 1 33.40434966 96 24 10303 13.41536458 1 1 35.67444878 119 190 13496 3.581424149 1 0.721314844 33.74978787 76 174 7684 3.486388385 0.999999935 0.984020341 33.41530709 96 30 10303 10.73229167 1 1 49.06983377 96 76 10303 5.648574561 1 1 51.23904259 115 127 13101 3.588086272 1 1 86.5802837 List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 27 11642 12.5587918 1 0.883521408 36.03582926 103 27 11642 12.5587918 1 0.883521408 36.03582926 103 35 11642 9.688210818 1 0.95138525 51.78240671

5100, 8013, 116039, 56963, 23405, 4838, 10361, 3491, 3909, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 267 11642 3.809970547 0.999994568 0.279389542 4.399567242 103 108 11642 4.186263934 1 0.98992097 74.46055241 103 108 11642 4.186263934 1 0.98992097 74.46055241 103 111 11642 4.073121665 1 0.991246447 76.76623667

1440, 2919, 5340, 3553, 116039, 3853, 1991, 3853, 5743, 4838, 942, 3491, 5371, 8626, 7097, 3624, 3159, 3043, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 468 11642 2.656667496 1 0.576604429 13.92174825 103 224 11642 3.532160194 1 0.754346463 23.33388346 103 736 11642 1.842866188 1 0.98300954 67.3446818 103 932 11642 1.697862411 1 0.987756592 71.11448769 103 1034 11642 1.639687518 1 0.988763589 73.17976732

6347, 2919, 9547, 3553, 1991, 2357, 3491, 2167, 3949, 10242, 3658, 5340, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 135 11642 5.860769507 0.997673856 0.194711858 2.225214563 103 135 11642 5.860769507 0.997673856 0.194711858 2.225214563 103 176 11642 4.495476611 1 0.414043176 8.176275599 103 239 11642 3.3104765 1 0.830463902 29.92914109 103 363 11642 2.491000027 1 0.954619997 54.18184502 103 185 11642 3.054841249 1 0.992003609 79.34134365 103 185 11642 3.054841249 1 0.992003609 79.34134365 103 268 11642 2.530502826 1 0.993539066 82.12056775 103 202 11642 2.797750649 1 0.99611556 86.98989374 103 138 11642 3.276206557 1 0.998373684 91.41080765 103 139 11642 3.252636726 1 0.998348583 91.76157003 103 157 11642 2.879722961 1 0.999470392 96.32446126 103 158 11642 2.861496866 1 0.999493754 96.49643742 103 108 11642 3.13969795 1 0.999970694 99.52315205 103 108 11642 3.13969795 1 0.999970694 99.52315205 103 116 11642 2.923167057 1 0.99998704 99.75562622 103 116 11642 2.923167057 1 0.99998704 99.75562622

1308, 667, 3909, 5239, 2572, 1825, 2709, 84951, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 33 12300 10.16528926 1 0.950430771 41.8352724 110 352 12300 2.541322314 1 0.93189917 44.09541425 110 80 12300 4.193181818 1 0.999947597 93.05179623

5239, 1308, 1825, 2709, 667, 2572, 84951, 3909, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 139 12300 4.022236756 1 0.937956327 42.39408365 110 352 12300 2.541322314 1 0.93189917 44.09541425 119 264 13496 2.147950089 1 0.999421229 97.11656012

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 115 212 13101 3.224200164 1 0.999999997 52.31880735 76 212 7684 2.861469712 1 0.998968394 57.05030217 119 47 13496 7.239048811 1 0.940821676 64.69766936 96 115 10303 3.732971014 1 1 86.73452969 96 117 10303 3.669159544 1 1 87.8182549 115 202 13101 2.819845028 1 1 86.78415788 96 83 10303 3.879141566 1 1 98.51128538 96 86 10303 3.743822674 1 1 98.85385954

3553, 2167, 3624, 1991, 942, 7097, 3043, 5371, 8626, 3159, 2572, 5743, 3067, 245973, 3949, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 115 11642 5.897171802 0.999999969 0.350791232 6.211779698 103 62 11642 7.292201691 1 0.810601738 27.91220855 103 71 11642 6.367838097 1 0.878469424 37.45664953 103 71 11642 6.367838097 1 0.878469424 37.45664953 103 72 11642 6.279395901 1 0.883599508 38.54690587 103 88 11642 5.137687555 1 0.957122158 55.87658738 103 41 11642 8.270423869 1 0.974301309 62.40675728 103 420 11642 2.152935737 1 0.991790779 77.62360169 103 54 11642 6.279395901 1 0.992042298 80.10093551 103 195 11642 2.898182723 1 0.99517489 84.1340366 103 61 11642 5.558809486 1 0.995981201 86.55382925 103 162 11642 2.790842623 1 0.99962812 97.11668645 103 177 11642 2.554330536 1 0.999887878 98.67127798 103 283 11642 1.996981029 1 0.999959425 99.41515193 103 394 11642 1.721255729 1 0.999985514 99.70638662 103 890 11642 1.142991164 1 1 99.99992827 103 1212 11642 0.93258355 1 1 100 103 442 11642 1.02288802 1 1 100 103 698 11642 0.809664228 1 1 100

5340, 5371, 8626, 3624, 5743, 1490, 3491, 10481, 7097, 6347, 3553, 23213, 8771, 84951, 23405, 4838, 5896, 1959, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 266 11642 3.399372217 1 0.61154367 15.50228122 103 190 11642 3.569340828 1 0.884230622 39.1116832 103 144 11642 3.924622438 1 0.947321866 51.90203442 103 174 11642 3.247963397 1 0.989286447 73.10282399 103 179 11642 3.157238162 1 0.990885178 76.06123315 103 54 11642 6.279395901 1 0.992042298 80.10093551 103 55 11642 6.165225066 1 0.992848058 81.14685926 103 198 11642 2.854270864 1 0.995741942 85.4075203 103 199 11642 2.839927794 1 0.995837543 85.81540749 103 64 11642 5.298240291 1 0.997219665 88.74268268 103 237 11642 2.384580722 1 0.999480985 95.92392845 103 239 11642 2.364626071 1 0.999502905 96.21738567 103 720 11642 1.569848975 1 0.99975569 97.68500675 103 726 11642 1.556875017 1 0.999808244 97.99032866 103 1132 11642 1.39788672 1 0.999836892 98.19286729 103 767 11642 1.473652232 1 0.999953485 99.29943124 103 767 11642 1.473652232 1 0.999953485 99.29943124 103 496 11642 1.59516912 1 0.99998761 99.74055419 103 501 11642 1.579249268 1 0.999988258 99.78690657 119 277 13496 1.637715014 1 0.999999503 99.98918753 103 440 11642 1.284421889 1 1 99.99996604 103 440 11642 1.284421889 1 1 99.99996604 List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 69 11642 4.914309835 1 0.998431607 91.72966094 103 149 11642 3.034338959 1 0.999287769 94.66917009 103 238 11642 2.374561475 1 0.999492025 96.07295659 103 81 11642 4.186263934 1 0.999488497 96.27676896

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 115 107 13101 4.258756603 1 1 73.47585292 76 107 7684 3.779636006 1 0.999883247 73.69734077 115 210 13101 2.71242236 1 1 89.59319194 119 215 13496 2.6374829 1 0.990900204 86.72420015 96 92 10303 3.499660326 1 1 99.33121861 96 106 10303 3.037441038 1 1 99.82356253 96 117 10303 2.751869658 1 1 99.94211003 96 124 10303 2.596522177 1 1 99.97230553 96 124 10303 2.596522177 1 1 99.97230553

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 113 13496 5.018219677 0.999999984 0.652731931 24.11197776 119 98 13496 3.471788715 1 0.999534049 97.6879865 114 115 12615 2.886727689 1 1 99.68510422 114 115 12615 2.886727689 1 1 99.68510422 119 210 13496 2.16022409 1 0.999915217 99.4367864 114 257 12615 1.722301864 1 1 99.99090248

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 125 12615 3.541052632 1 0.999999736 85.35591184 114 127 12615 3.485288023 1 0.999999688 86.39458103 114 83 12615 3.999682942 1 0.999999993 96.45310553 114 231 12615 1.916154021 1 1 99.94426146 114 709 12615 0.936456091 1 1 100 List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 113 13496 5.018219677 0.999999984 0.652731931 24.11197776 119 460 13496 0.739641944 1 1 100 114 696 12615 0.635964912 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 104 11642 4.347274085 1 0.987128201 71.17326347 103 75 11642 4.521165049 1 0.999245539 94.39594164 103 183 11642 2.470581994 1 0.999929786 99.04362616 103 196 11642 2.306716862 1 0.999969231 99.5473906 103 208 11642 2.173637043 1 0.99998871 99.78238887 103 171 11642 1.982967127 1 0.999999993 99.99861536 103 196 11642 1.730037646 1 1 99.9998993 103 222 11642 1.527420625 1 1 99.99999428

6347, 3598, 10560, 10332, 3553, 8771, 1755, 26166, 5187, 2357, 942, 7097, 5157, 8013, 3624, 8864, 3949, 54210, 25960, 2152, 7057, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 1723 12615 1.348703302 1 0.999999896 92.17869493 114 1723 12615 1.348703302 1 0.999999896 92.17869493 114 810 12615 1.366146849 1 1 99.83389291 114 1326 12615 1.16833373 1 1 99.99177457 119 1044 13496 1.086319585 1 0.99999999 99.99983334

6347, 10560, 4053, 3553, 8626, 168667, 1490, 667, 2357, 7097, 1440, 2919, 2487, 3624, 25960, 3159, 3909, 9547, 2572, 4680, 10332, 2709, 26166, 5187, 54210, 10242, 1959, 84951, 942, 5100, 8864, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 1252 11642 1.534740532 1 0.992673478 78.79371067 103 3223 11642 1.087155728 1 0.999999924 99.99033273 103 2897 11642 0.975398052 1 1 99.9999999

5371, 3624, 8434, 1755, 667, 4053, 3553, 10361, 25975, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 199 11642 2.839927794 1 0.995837543 85.81540749 103 500 11642 1.808466019 1 0.999460343 95.36638351 103 503 11642 1.79767994 1 0.999482187 95.69270185 103 79 11642 4.292245299 1 0.999455888 95.7240419 103 696 11642 1.299185359 1 0.999999972 99.99575599 103 815 11642 1.2481744 1 0.999999983 99.99723329 103 297 11642 1.141708346 1 1 100 103 325 11642 1.04334578 1 1 100

5340, 1991, 2191, 5408, 5239, 1513, 827, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 96 125 10303 3.434333333 1 1 91.48692248 114 147 12615 3.011099177 1 0.999999923 93.93992524 114 164 12615 2.698973042 1 0.999999997 97.24347648 114 165 12615 2.68261563 1 0.999999995 97.37552747 114 351 12615 1.891587944 1 0.999999999 98.40730534 119 107 13496 3.179769104 1 0.999818182 98.72385543 119 178 13496 1.911434237 1 0.999999773 99.99478193 114 537 12615 1.236401059 1 1 99.99986026 119 387 13496 1.172214622 1 1 99.99999668 103 639 11642 1.061306349 1 1 99.99999992

9705, 5371, 8626, 2167, 3624, 1991, 5187, 942, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 358 11642 2.210066714 1 0.995539223 84.86528114 103 401 11642 1.973077016 1 0.999279891 94.3499338 103 277 11642 2.040236935 1 0.999947296 99.22677611 103 304 11642 1.859031681 1 0.999987923 99.79254236 114 213 12615 2.07808253 1 1 99.82165468 119 341 13496 1.330343281 1 0.999999991 99.9998797 103 447 11642 0.75858474 1 1 100 103 627 11642 0.540809216 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 108 13496 3.150326797 1 0.999794288 98.80744127 114 111 12615 2.990753912 1 1 99.56407302 114 407 12615 1.631320316 1 1 99.833822 114 231 12615 1.916154021 1 1 99.94426146 96 149 10303 2.160864094 1 1 99.99830279 114 182 12615 1.824031232 1 1 99.99934857 5371, 3553, 8626, 3624, 1991, 3043, 3159, 942, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 420 11642 2.152935737 1 0.991790779 77.62360169 103 394 11642 1.721255729 1 0.999985514 99.70638662 114 293 12615 1.510687983 1 1 99.99941525 103 309 11642 1.46316021 1 1 99.99988358 103 319 11642 1.417293119 1 1 99.99995078 103 251 11642 1.350945732 1 1 99.9999998

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 96 75 10303 4.292916667 1 1 97.08974064 115 143 13101 2.389966555 1 1 99.97817827 119 353 13496 1.606398934 1 0.999995679 99.93839676 115 272 13101 1.675319693 1 1 99.9975158 76 286 7684 1.414059625 1 1 99.99869753 115 355 13101 1.28362523 1 1 99.99999795 115 389 13101 1.171431765 1 1 99.99999992

2572, 10560, 4060, 3949, 5743, 2202, 3043, 10242, 2070, 1959, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 954 11642 1.184791679 1 0.999999997 99.99920889 103 186 11642 1.823050423 1 0.999999999 99.99970771 103 186 11642 1.823050423 1 0.999999999 99.99970771 103 704 11642 1.123869153 1 1 99.99999541 103 405 11642 1.116337049 1 1 99.99999998

1308, 2572, 10332, 4680, 1825, 2709, 84951, 667, 942, 7220, 7097, 3772, 5239, 5100, 3949, 5743, 10242, 3909, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 1626 12300 1.237839651 1 0.999999679 99.22051692 110 1100 12300 0.914876033 1 1 99.99999999 110 1115 12300 0.902568284 1 1 99.99999999

57198, 6291, 3949, 350, 1308, 10560, 10332, 3553, 11117, 245973, 7097, 5340, 10242, 7057, 3909, 4053, 1991, 667, 1490, 81575, 2357, 7220, 3772, 5268, 2167, 3624, 3043, 5743, 4838, 57685, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 73 12615 6.063446287 1 0.999248783 39.45628702 103 2661 11642 1.189333158 1 0.999945007 99.18110758 103 449 11642 1.510411486 1 0.999999746 99.9787136 103 677 11642 1.335646986 1 0.999999925 99.98982028 114 889 12615 1.244745723 1 1 99.98984332 119 435 13496 1.303583502 1 0.999999981 99.99938567 114 1127 12615 1.080068183 1 1 99.99995945 114 226 12615 1.468910107 1 1 99.99999368 103 373 11642 1.212108592 1 1 99.99999965 114 258 12615 1.286719706 1 1 99.99999982 119 267 13496 1.274289491 1 1 99.99999868 103 279 11642 1.215366949 1 1 99.99999999 114 275 12615 1.207177033 1 1 99.99999998 103 2330 11642 0.921696737 1 1 100 114 711 12615 0.933821897 1 1 100 114 319 12615 1.040669856 1 1 100 114 460 12615 0.962242563 1 1 100 103 2246 11642 0.905843398 1 1 100 114 327 12615 1.015210043 1 1 100 114 610 12615 0.907031924 1 1 100 114 349 12615 0.951213995 1 1 100 114 349 12615 0.951213995 1 1 100 114 792 12615 0.838317384 1 1 100 119 1249 13496 0.817218481 1 1 100

2176, 5371, 8626, 3159, 942, 23405, 5896, 1490, 10361, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 277 11642 1.632189548 1 0.999999992 99.99838975 114 293 12615 1.510687983 1 1 99.99941525 103 495 11642 1.141708346 1 1 99.99999957 103 529 11642 1.068328225 1 1 99.99999998 103 683 11642 0.992935223 1 1 100

1308, 2572, 4680, 1825, 10332, 8434, 2709, 7097, 54210, 10242, 2152, 3909, 56963, 2191, 84951, 81575, 1490, 667, 942, 2357, 7220, 3772, 5239, 5100, 3949, 5743, 25960, 3598, 10560, 57198, 79586, 7367, 1755, 245973, 81671, 79838, 81833, 9911, 9043, 2192, 57685, 158326, 6347, 25975, 79870, 2487, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 110 2434 12300 1.240382461 1 0.999956231 94.47798195 96 1498 10303 1.289594459 1 1 99.39901324 96 1918 10303 1.063157152 1 1 99.99997608 110 4520 12300 0.94006436 1 1 99.99999997 110 5455 12300 0.942921423 1 1 99.99999999 96 2489 10303 0.905496685 1 1 100 119 3250 13496 0.87239819 1 1 100 110 3915 12300 0.856844305 1 1 100 110 3934 12300 0.852706013 1 1 100 119 4190 13496 0.839084655 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 179 11642 1.894342897 1 0.999999997 99.99939194 103 179 11642 1.894342897 1 0.999999997 99.99939194 103 264 11642 1.284421889 1 1 99.99999996 103 464 11642 0.730791764 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 215 11642 1.577150598 1 1 99.99998745 103 221 11642 1.53433203 1 1 99.99999359 103 226 11642 1.500386631 1 1 99.99999636 103 437 11642 1.034591544 1 1 100 103 501 11642 0.902428153 1 1 100

9705, 116039, 1825, 10332, 23213, 164633, 3620, 8404, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 124, 3772, 244, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, 79586, 5239, 57198, 3899, 1820, 3159, 5307, 10481, 23405, 8771, 10361, 29974, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 3207 12615 1.242184038 1 0.999999474 86.69644643 119 2232 13496 1.016234451 1 0.999999993 99.99992715 119 1478 13496 0.920799172 1 1 99.99999998 114 2844 12615 0.778184914 1 1 100 114 1955 12615 0.735832548 1 1 100 119 1354 13496 0.670084282 1 1 100 119 1691 13496 0.67067868 1 1 100 114 2327 12615 0.713308303 1 1 100 114 1921 12615 0.633647497 1 1 100

57198, 5340, 1513, 23213, 23405, 1991, 2191, 5209, 5408, 245973, 5896, 2070, 8771, 5239, 827, 2572, 7367, 5187, 3620, 7097, 6347, 79586, 3658, 124, 5157, 5743, 3067, 25976, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 1218 13496 1.117357288 1 0.999999947 99.99841657 114 576 12615 1.152686404 1 1 99.99998934 114 1907 12615 0.870408191 1 1 100 114 4619 12615 0.670799102 1 1 100

5371, 3159, 10361, 2176, 5896, 1490, 2919, 286887, 667, 29974, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 189 11642 1.794113115 1 0.999999999 99.99978719 103 272 11642 1.246644774 1 1 99.99999998 103 278 11642 1.219738772 1 1 99.99999999 103 683 11642 0.992935223 1 1 100 103 346 11642 0.980021326 1 1 100 103 1059 11642 0.64039165 1 1 100 110 976 12300 0.458271237 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 264 11642 1.284421889 1 1 99.99999996 103 431 11642 1.048994211 1 1 100 103 324 11642 1.046565983 1 1 100 103 491 11642 0.920807546 1 1 100 103 494 11642 0.915215597 1 1 100 103 400 11642 0.847718447 1 1 100

3899, 5371, 8626, 5307, 2070, 1959, 9705, 8013, 1820, 3159, 10481, 5187, 8864, 349075, 3553, 23405, 1991, 942, 2167, 3624, 5896, 3043, 245973, 10361, 2176, 8771, 1490, 29974, 116039, 3658, 79413, 25976, 219539, 2572, 23213, 7367, 5209, 3620, 5340, 827, 6347, 2191, 5408, 81575, 124, 5239, 1513, 3949, 5743, 3067, 7097, 57198, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 399 13496 1.705440071 1 0.999910084 99.32877822 114 831 12615 1.198460954 1 1 99.99880989 119 1544 13496 1.028345017 1 0.999999994 99.99995335 103 2253 11642 1.003365523 1 1 99.99999869 119 1576 13496 1.007464915 1 0.999999998 99.99998687 114 1249 12615 0.974569129 1 1 99.99999993 119 1478 13496 0.920799172 1 1 99.99999998 114 441 12615 1.003699726 1 1 100 103 2454 11642 0.921182773 1 1 100 103 2109 11642 0.911093004 1 1 100 103 2362 11642 0.909209737 1 1 100 103 2168 11642 0.886298499 1 1 100 103 2192 11642 0.876594501 1 1 100 103 1986 11642 0.853694307 1 1 100 103 2036 11642 0.832729319 1 1 100 103 2039 11642 0.831504116 1 1 100 103 3284 11642 0.860453153 1 1 100 103 2968 11642 0.799734384 1 1 100 114 2844 12615 0.778184914 1 1 100 114 1955 12615 0.735832548 1 1 100 103 2520 11642 0.762498074 1 1 100 119 3283 13496 0.690903227 1 1 100 103 6634 11642 0.783741303 1 1 100 110 3980 12300 0.618090452 1 1 100 103 6674 11642 0.745172543 1 1 100 103 4413 11642 0.640319093 1 1 100 103 5817 11642 0.699509806 1 1 100 103 7289 11642 0.75983361 1 1 100

57198, 23405, 8771, 245973, 5209, 29974, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 249 12615 1.333227647 1 1 99.99999951 114 299 12615 1.11027988 1 1 100 114 551 12615 0.8033241 1 1 100 114 519 12615 0.63964101 1 1 100 114 546 12615 0.608010411 1 1 100 114 549 12615 0.604687949 1 1 100 114 1237 12615 0.447283326 1 1 100 114 1252 12615 0.4419245 1 1 100 114 1322 12615 0.418524564 1 1 100 119 1003 13496 0.339217641 1 1 100 114 1533 12615 0.360919422 1 1 100 114 1533 12615 0.360919422 1 1 100 114 1605 12615 0.344728644 1 1 100 114 1843 12615 0.360253591 1 1 100 119 1282 13496 0.265394145 1 1 100

6347, 5157, 5209, 5187, 79586, 7367, 25976, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 114 657 12615 0.673716254 1 1 100 114 557 12615 0.596003024 1 1 100 114 792 12615 0.558878256 1 1 100 114 917 12615 0.482695288 1 1 100 114 1594 12615 0.485950604 1 1 100

6347, 2176, 5371, 3553, 8626, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, 9705, 2572, 5209, 1820, 5187, 10361, 349075, 5896, 1959, 23405, 1490, 10481, 2070, 3899, 8013, 8864, 5307, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 2994 11642 0.717285704 1 1 100 103 2801 11642 0.686003265 1 1 100 103 2846 11642 0.675156411 1 1 100 103 5817 11642 0.699509806 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 636 11642 0.533156256 1 1 100 103 784 11642 0.432509412 1 1 100 103 803 11642 0.422275689 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 705 11642 0.480975005 1 1 100 103 851 11642 0.398457554 1 1 100 103 851 11642 0.398457554 1 1 100

9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, 79586, 2572, 9547, 23213, 7367, 1755, 667, 2357, 4969, 1513, 9043, 3949, 5743, 81671, 3043, 25976, 6347, 23405, 1991, 1490, 3624, 1308, 10332, 11117, 84951, 22870, 3658, 124, 79870, 2167, 1825, 81851, 3853, 83957, 286887, 3854, 3853, 3861, 3885, 827, 10560, 8434, 245973, 7097, 57198, 54210, 10242, 2152, 3909, 9911, 25975, 3772, 2192, 25960, 57685, 4680, 2709, 79838, 158326, 81833, 3598, 56963, 8771, 2191, 81575, 942, 7220, 5239, 5100, 2487, List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 119 3283 13496 0.690903227 1 1 100 110 3171 12300 0.634729509 1 1 100 110 3980 12300 0.618090452 1 1 100 103 4413 11642 0.640319093 1 1 100 110 5424 12300 0.659694288 1 1 100 110 6974 12300 0.721511067 1 1 100 110 6978 12300 0.721097475 1 1 100 110 6200 12300 0.631231672 1 1 100 110 6203 12300 0.630926385 1 1 100 110 8379 12300 0.720632751 1 1 100 110 8772 12300 0.713841562 1 1 100 110 11735 12300 0.848045861 1 1 100 110 11736 12300 0.847973601 1 1 100

List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR 103 1618 11642 0.349286546 1 1 100 103 1313 11642 0.258253906 1 1 100 103 1552 11642 0.291312181 1 1 100 1308, 9547, 3553, 23213, 6291, 11117, 81851, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 158326, 7057, 3909, 6347, 3512, 4053, 3598, 25975, 1991, 168667, 4060, 5408, 2202, 1490, 81575, 667, 3491, 2919, 6279, 2487, 3624, 3918, 350, 2192, 4838, 1825, 7367, 8434, 7097, 54210, 2152, 25890, 5268, 3949, 5743, 25960, 57685, 4680, 81833, 56963, 8771, 84951, 942, 5100, 1513, 5157, 10560, 10332, 10242, 3043, 79586, 2191, 2357,

1308, 10560, 116039, 3553, 8434, 7097, 1440, 5340, 10242, 5896, 7057, 2152, 3909, 5371, 25975, 4060, 1991, 5408, 10481, 3491, 8013, 3918, 3949, 3043, 5743, 5307, 2572, 2709, 10361, 7980, 3853, 158326, 1959, 6347, 56963, 23405, 8626, 2202, 1490, 81575, 942, 2070, 244, 2919, 3899, 5100, 2487, 2167, 3624, 3853, 3854, 3861, 350, 4838, 3885, 1755, 23213, 8771, 84951,

1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, 6291, 1991, 5187, 2357, 3491, 10481, 7097, 244, 2167, 350, 5743, 2152, 1959, 5371, 8626, 3658, 29974, 3949, 3043, 10242, 5408, 1755, 10332, 3620, 54210, 5896, 2176, 3512, 23405, 942, 3159, 8771, 84951,

1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, 9705, 1991, 168667, 26166, 5187, 667, 2167, 349075, 3159, 2152, 22870, 29974, 3949, 8864, 2572, 1820, 7980, 4053, 2357, 3658, 244, 350,

1308, 286887, 1825, 3853, 3854, 3918, 3853, 2709, 3861, 7057, 3885, 3909, 5743, 1490, 10481, 5340, 8013, 5307, 81851, 11117, 4060, 667, 7980, 5239, 2192, 83957, 84951, 5371, 10361, 3159, 2572, 1755, 29974, 4053, 1825, 10332, 25975, 23213, 3241, 2202, 164633, 667, 7220, 244, 8404, 5100, 5340, 6279, 3949, 2192, 57685, 158326, 7057, 9705, 116039, 245973, 3620, 57198, 79413, 349075, 5896, 1959, 79586, 5371, 8626, 3658, 2070, 124, 3772, 5239, 8013, 5743, 3043, 25976,

6347, 10560, 4053, 3553, 8626, 168667, 1490, 667, 2357, 7097, 1440, 2919, 2487, 3624, 25960, 3159, 3909, 9547, 2572, 4680, 10332, 2709, 26166, 5187, 54210, 10242, 1959, 84951, 942, 5100, 8864,

57198, 6291, 3949, 350, 1308, 10560, 10332, 3553, 11117, 245973, 7097, 5340, 10242, 7057, 3909, 4053, 1991, 667, 1490, 81575, 2357, 7220, 3772, 5268, 2167, 3624, 3043, 5743, 4838, 57685, 1308, 2572, 4680, 1825, 10332, 8434, 2709, 7097, 54210, 10242, 2152, 3909, 56963, 2191, 84951, 81575, 1490, 667, 942, 2357, 7220, 3772, 5239, 5100, 3949, 5743, 25960, 3598, 10560, 57198, 79586, 7367, 1755, 245973, 81671, 79838, 81833, 9911, 9043, 2192, 57685, 158326, 6347, 25975, 79870, 2487, 9705, 116039, 1825, 10332, 23213, 164633, 3620, 8404, 5340, 79413, 349075, 5896, 158326, 7057, 1959, 4053, 5371, 25975, 8626, 3241, 2202, 667, 7220, 3658, 124, 3772, 244, 5100, 6279, 8013, 3949, 5743, 3043, 2192, 57685, 25976, 79586, 5239, 57198, 3899, 1820, 3159, 5307, 10481, 23405, 8771, 10361, 29974, 3899, 5371, 8626, 5307, 2070, 1959, 9705, 8013, 1820, 3159, 10481, 5187, 8864, 349075, 3553, 23405, 1991, 942, 2167, 3624, 5896, 3043, 245973, 10361, 2176, 8771, 1490, 29974, 116039, 3658, 79413, 25976, 219539, 2572, 23213, 7367, 5209, 3620, 5340, 827, 6347, 2191, 5408, 81575, 124, 5239, 1513, 3949, 5743, 3067, 7097, 57198,

6347, 2176, 5371, 3553, 8626, 23213, 1991, 2191, 81575, 942, 5239, 5340, 1513, 3624, 29974, 3949, 3159, 827, 25976, 9705, 2572, 5209, 1820, 5187, 10361, 349075, 5896, 1959, 23405, 1490, 10481, 2070, 3899, 8013, 8864, 5307,

9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, 79586, 2572, 9547, 23213, 7367, 1755, 667, 2357, 4969, 1513, 9043, 3949, 5743, 81671, 3043, 25976, 6347, 23405, 1991, 1490, 3624, 1308, 10332, 11117, 84951, 22870, 3658, 124, 79870, 2167, 1825, 81851, 3853, 83957, 286887, 3854, 3853, 3861, 3885, 827, 10560, 8434, 245973, 7097, 57198, 54210, 10242, 2152, 3909, 9911, 25975, 3772, 2192, 25960, 57685, 4680, 2709, 79838, 158326, 81833, 3598, 56963, 8771, 2191, 81575, 942, 7220, 5239, 5100, 2487,

1308, 9547, 3553, 23213, 6291, 11117, 81851, 1755, 7980, 4969, 1440, 8404, 5340, 64388, 158326, 7057, 3909, 6347, 3512, 4053, 3598, 25975, 1991, 168667, 4060, 5408, 2202, 1490, 81575, 667, 3491, 2919, 6279, 2487, 3624, 3918, 350, 2192, 4838, 1825, 7367, 8434, 7097, 54210, 2152, 25890, 5268, 3949, 5743, 25960, 57685, 4680, 81833, 56963, 8771, 84951, 942, 5100, 1513, 5157, 10560, 10332, 10242, 3043, 79586, 2191, 2357,

1308, 10560, 116039, 3553, 8434, 7097, 1440, 5340, 10242, 5896, 7057, 2152, 3909, 5371, 25975, 4060, 1991, 5408, 10481, 3491, 8013, 3918, 3949, 3043, 5743, 5307, 2572, 2709, 10361, 7980, 3853, 158326, 1959, 6347, 56963, 23405, 8626, 2202, 1490, 81575, 942, 2070, 244, 2919, 3899, 5100, 2487, 2167, 3624, 3853, 3854, 3861, 350, 4838, 3885, 1755, 23213, 8771, 84951,

1308, 9547, 3553, 23213, 11117, 7980, 4969, 1440, 8404, 5340, 64388, 7057, 158326, 3909, 6347, 4053, 3598, 25975, 4060, 2202, 667, 1490, 2919, 6279, 3624, 3918, 2192, 4838, 6291, 1991, 5187, 2357, 3491, 10481, 7097, 244, 2167, 350, 5743, 2152, 1959, 5371, 8626, 3658, 29974, 3949, 3043, 10242, 5408, 1755, 10332, 3620, 54210, 5896, 2176, 3512, 23405, 942, 3159, 8771, 84951,

1308, 3553, 116039, 23213, 8434, 2709, 1755, 10361, 7097, 1440, 5340, 3853, 5896, 10242, 158326, 7057, 3909, 1959, 6347, 5371, 25975, 56963, 8626, 23405, 8771, 84951, 81575, 1490, 942, 3491, 10481, 2070, 3899, 2919, 5100, 8013, 2487, 3624, 3854, 3853, 3918, 3861, 5743, 3043, 4838, 3885, 5307, 9705, 1991, 168667, 26166, 5187, 667, 2167, 349075, 3159, 2152, 22870, 29974, 3949, 8864, 2572, 1820, 7980, 4053, 2357, 3658, 244, 350,

3899, 5371, 8626, 5307, 2070, 1959, 9705, 8013, 1820, 3159, 10481, 5187, 8864, 349075, 3553, 23405, 1991, 942, 2167, 3624, 5896, 3043, 245973, 10361, 2176, 8771, 1490, 29974, 116039, 3658, 79413, 25976, 219539, 2572, 23213, 7367, 5209, 3620, 5340, 827, 6347, 2191, 5408, 81575, 124, 5239, 1513, 3949, 5743, 3067, 7097, 57198,

9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, 79586, 2572, 9547, 23213, 7367, 1755, 667, 2357, 4969, 1513, 9043, 3949, 5743, 81671, 3043, 25976, 6347, 23405, 1991, 1490, 3624, 1308, 10332, 11117, 84951, 22870, 3658, 124, 79870, 2167, 1825, 81851, 3853, 83957, 286887, 3854, 3853, 3861, 3885, 827, 10560, 8434, 245973, 7097, 57198, 54210, 10242, 2152, 3909, 9911, 25975, 3772, 2192, 25960, 57685, 4680, 2709, 79838, 158326, 81833, 3598, 56963, 8771, 2191, 81575, 942, 7220, 5239, 5100, 2487,

9705, 2176, 5371, 116039, 8626, 1820, 5187, 10361, 10481, 2070, 3899, 8013, 29974, 8864, 349075, 3159, 5896, 5307, 219539, 1959, 79586, 2572, 9547, 23213, 7367, 1755, 667, 2357, 4969, 1513, 9043, 3949, 5743, 81671, 3043, 25976, 6347, 23405, 1991, 1490, 3624, 1308, 10332, 11117, 84951, 22870, 3658, 124, 79870, 2167, 1825, 81851, 3853, 83957, 286887, 3854, 3853, 3861, 3885, 827, 10560, 8434, 245973, 7097, 57198, 54210, 10242, 2152, 3909, 9911, 25975, 3772, 2192, 25960, 57685, 4680, 2709, 79838, 158326, 81833, 3598, 56963, 8771, 2191, 81575, 942, 7220, 5239, 5100, 2487,