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WHO Drug Information Vol. 12, No. 3, 1998
WHO DRUG INFORMATION VOLUME 12 NUMBER 3 • 1998 RECOMMENDED INN LIST 40 INTERNATIONAL NONPROPRIETARY NAMES FOR PHARMACEUTICAL SUBSTANCES WORLD HEALTH ORGANIZATION • GENEVA Volume 12, Number 3, 1998 World Health Organization, Geneva WHO Drug Information Contents Seratrodast and hepatic dysfunction 146 Meloxicam safety similar to other NSAIDs 147 Proxibarbal withdrawn from the market 147 General Policy Issues Cholestin an unapproved drug 147 Vigabatrin and visual defects 147 Starting materials for pharmaceutical products: safety concerns 129 Glycerol contaminated with diethylene glycol 129 ATC/DDD Classification (final) 148 Pharmaceutical excipients: certificates of analysis and vendor qualification 130 ATC/DDD Classification Quality assurance and supply of starting (temporary) 150 materials 132 Implementation of vendor certification 134 Control and safe trade in starting materials Essential Drugs for pharmaceuticals: recommendations 134 WHO Model Formulary: Immunosuppressives, antineoplastics and drugs used in palliative care Reports on Individual Drugs Immunosuppresive drugs 153 Tamoxifen in the prevention and treatment Azathioprine 153 of breast cancer 136 Ciclosporin 154 Selective serotonin re-uptake inhibitors and Cytotoxic drugs 154 withdrawal reactions 136 Asparaginase 157 Triclabendazole and fascioliasis 138 Bleomycin 157 Calcium folinate 157 Chlormethine 158 Current Topics Cisplatin 158 Reverse transcriptase activity in vaccines 140 Cyclophosphamide 158 Consumer protection and herbal remedies 141 Cytarabine 159 Indiscriminate antibiotic -
IP Vol.2 No.2 Jul-Dec 2014.Pmd
International Physiology63 Short Communication Vol. 2 No. 2, July - December 2014 Role of Polyol Pathway in Pathophysiology of Diabetic Peripheral Neuropathy: An Updated Overview Kumar Senthil P.*, Adhikari Prabha**, Jeganathan*** Abstract The aim of this short communication article was to enlighten the role of polyol pathway in pathophysiology of diabetic peripheral neuropathy (DPN) through an evidence-informed overview of current literature. Findings from experimental models of DPN suggest that altered glutathione redox state, with exaggerated NA(+)-K(+)-ATPase activity, increased malondialdehyde content, decreased red blood cell 2,3-diphosphoglycerate concentration, reduced cyclic adenosine monophosphate, reduced myo- inositol and excessive sorbitol in peripheral nerves were indicative of polyol metabolic pathwayin producing pathophysiological changes of DPN, and treatments using aldose reductase inhibitors were found to reverse those changes. Keywords: Polyol pathway; Myo-inositol; Sorbitol; Neurophysiology; Endocrinology. The aim of this short communication oxidized (GSSG) glutathione levels in crude article was to enlighten the role of polyol homogenates of rat sciatic nerve. The study pathway in pathophysiology of diabetic concluded that altered glutathione redox peripheral neuropathy (DPN) through an state played no detectable role in the evidence-informed overview of current pathogenesis of this defect in diabetic literature. peripheral nerve. Calcutt et al[1] measured motor nerve Finegold et al[3] studied the effect of conduction velocity (MNCV), Na(+)-K(+)- polyol pathway blockade with sorbinil, a ATPase activity, polyol-pathway specific inhibitor of aldose reductase, on metabolites, and myo-inositol in sciatic nerve myo-inositol content in acutely nerves from control mice, galactose-fed streptozotocin-diabetic ratswhich (20% wt/wt diet) mice, and galactose-fed completely prevented the fall in nerve myo- mice given the aldose reductase inhibitor inositol. -
Classification Decisions Taken by the Harmonized System Committee from the 47Th to 60Th Sessions (2011
CLASSIFICATION DECISIONS TAKEN BY THE HARMONIZED SYSTEM COMMITTEE FROM THE 47TH TO 60TH SESSIONS (2011 - 2018) WORLD CUSTOMS ORGANIZATION Rue du Marché 30 B-1210 Brussels Belgium November 2011 Copyright © 2011 World Customs Organization. All rights reserved. Requests and inquiries concerning translation, reproduction and adaptation rights should be addressed to [email protected]. D/2011/0448/25 The following list contains the classification decisions (other than those subject to a reservation) taken by the Harmonized System Committee ( 47th Session – March 2011) on specific products, together with their related Harmonized System code numbers and, in certain cases, the classification rationale. Advice Parties seeking to import or export merchandise covered by a decision are advised to verify the implementation of the decision by the importing or exporting country, as the case may be. HS codes Classification No Product description Classification considered rationale 1. Preparation, in the form of a powder, consisting of 92 % sugar, 6 % 2106.90 GRIs 1 and 6 black currant powder, anticaking agent, citric acid and black currant flavouring, put up for retail sale in 32-gram sachets, intended to be consumed as a beverage after mixing with hot water. 2. Vanutide cridificar (INN List 100). 3002.20 3. Certain INN products. Chapters 28, 29 (See “INN List 101” at the end of this publication.) and 30 4. Certain INN products. Chapters 13, 29 (See “INN List 102” at the end of this publication.) and 30 5. Certain INN products. Chapters 28, 29, (See “INN List 103” at the end of this publication.) 30, 35 and 39 6. Re-classification of INN products. -
Aldose Reductase Inhibitors for Diabetic Cataract: a Study of Disclosure Patterns in Patents and Peer Review Papers
Ophthalmology Research: An International Journal 2(3): 137-149, 2014, Article no. OR.2014.002 SCIENCEDOMAIN international www.sciencedomain.org Aldose Reductase Inhibitors for Diabetic Cataract: A Study of Disclosure Patterns in Patents and Peer Review Papers H. A. M. Mucke1*, E. Mucke1 and P. M. Mucke1 1H. M. Pharma Consultancy, Enenkelstr. 28/32, A-1160 Wien, Austria. Authors’ contributions This work was carried out in collaboration between all authors. Author MHAM designed the study, performed the analysis, and drafted the manuscript. Authors EM and PMM performed data curation and iterative information retrieval. All authors read and approved the final manuscript. Received 29th September 2013 th Original Research Article Accepted 11 December 2013 Published 15th January 2014 ABSTRACT Aims: To investigate, for 13 aldose reductase inhibitors that had been in development for diabetic cataract, whether patent documents could provide earlier dissemination of knowledge to the ophthalmology community than peer review papers. Methodology: Searches for intellectual property disclosures were conducted in our internal database of ophthalmology patent documents, and were supplemented by online searches in the public Espacenet and Google Patents databases. Searches for peer review papers were performed in Pub Med and Google Scholar, and in our internal database of machine-readable ophthalmology publications. Results: For sorbinil, tolrestat, fidarestat and GP-1447 patent documents clearly preempted the peer review literature in terms of data-supported information on potential effectiveness in diabetic cataract, typically by 7-17 months. For alrestatin, zenarestat, zopolrestat, indomethacin, and quercitrin academic journals were clearly first to properly report this therapeutic utility, preempting the corresponding patents by 6 months to several years. -
A Role for the Polyol Pathway in the Early Neuroretinal Apoptosis And
A Role for the Polyol Pathway in the Early Neuroretinal Apoptosis and Glial Changes Induced by Diabetes in the Rat Veronica Asnaghi, Chiara Gerhardinger, Todd Hoehn, Abidemi Adeboje, and Mara Lorenzi We tested the hypothesis that the apoptosis of inner Mu¨ ller cells (the glia that share functions with astrocytes retina neurons and increased expression of glial fibril- in the inner retina but span the whole thickness of the lary acidic protein (GFAP) observed in the rat after a retina with their radial processes) (3). In diabetes, Mu¨ ller short duration of diabetes are mediated by polyol path- cells acquire prominent GFAP immunoreactivity through- way activity. Rats with 10 weeks of streptozotocin- out the extension of their processes (4,5), whereas astro- induced diabetes and GHb levels of 16 ؎ 2% (mean ؎ cytes progressively lose GFAP immunoreactivity (6) and SD) showed increased retinal levels of sorbitol and may also decrease in number (7); the levels of GFAP fructose, attenuation of GFAP immunostaining in astro- measured in the whole retina are increased (4,5). cytes, appearance of prominent GFAP expression in The retinal neuroglial abnormalities are observed before Mu¨ ller glial cells, and a fourfold increase in the number of apoptotic neurons when compared with nondiabetic the characteristic lesions of diabetic microangiopathy; rats. The cells undergoing apoptosis were immunoreac- they occur predominantly in the inner retina, where the tive for aldose reductase. Sorbinil, an inhibitor of al- capillaries also reside; and they involve cells that are dose reductase, prevented all abnormalities. Intensive topographically and functionally connected with vessels. insulin treatment also prevented most abnormalities, Understanding their mechanisms and consequences may despite reducing GHb only to 12 ؎ 1%. -
Aldose Reductase
Aldose Reductase Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney. Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it. www.MedChemExpress.com 1 Aldose Reductase Inhibitors 6-Methoxytricin Aldose reductase-IN-1 Cat. No.: HY-N6883 Cat. No.: HY-18967 6-Methoxytricin (Compound 6) is an flavonoid Aldose reductase-IN-1 is a inhibitor of aldose isolated from Artemisia iwayomogi. reductase with IC50 of 28.9 pM. IC50 value: 28.9 pM Target: aldose reductase Detailed information please refer to WO2014113380 A1 and US20130225592. Purity: >98% Purity: 99.86% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Alrestatin Alrestatin sodium (AY-22284) Cat. No.: HY-B1202 (AY-22284A) Cat. No.: HY-B1202A Alrestatin is an inhibitor of aldose reductase, an Alrestatin sodium is an inhibitor of aldose enzyme involved in the pathogenesis of reductase, an enzyme involved in the pathogenesis complications of diabetes mellitus, including of complications of diabetes mellitus, including diabetic neuropathy. -
(12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr
US008158152B2 (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr. 17, 2012 (54) LYOPHILIZATION PROCESS AND 6,884,422 B1 4/2005 Liu et al. PRODUCTS OBTANED THEREBY 6,900, 184 B2 5/2005 Cohen et al. 2002fOO 10357 A1 1/2002 Stogniew etal. 2002/009 1270 A1 7, 2002 Wu et al. (75) Inventor: Nageswara R. Palepu. Mill Creek, WA 2002/0143038 A1 10/2002 Bandyopadhyay et al. (US) 2002fO155097 A1 10, 2002 Te 2003, OO68416 A1 4/2003 Burgess et al. 2003/0077321 A1 4/2003 Kiel et al. (73) Assignee: SciDose LLC, Amherst, MA (US) 2003, OO82236 A1 5/2003 Mathiowitz et al. 2003/0096378 A1 5/2003 Qiu et al. (*) Notice: Subject to any disclaimer, the term of this 2003/OO96797 A1 5/2003 Stogniew et al. patent is extended or adjusted under 35 2003.01.1331.6 A1 6/2003 Kaisheva et al. U.S.C. 154(b) by 1560 days. 2003. O191157 A1 10, 2003 Doen 2003/0202978 A1 10, 2003 Maa et al. 2003/0211042 A1 11/2003 Evans (21) Appl. No.: 11/282,507 2003/0229027 A1 12/2003 Eissens et al. 2004.0005351 A1 1/2004 Kwon (22) Filed: Nov. 18, 2005 2004/0042971 A1 3/2004 Truong-Le et al. 2004/0042972 A1 3/2004 Truong-Le et al. (65) Prior Publication Data 2004.0043042 A1 3/2004 Johnson et al. 2004/OO57927 A1 3/2004 Warne et al. US 2007/O116729 A1 May 24, 2007 2004, OO63792 A1 4/2004 Khera et al. -
Abstract Book
PROCEEDINGS OF THE International Seminar on Recent Advances in Chemistry and Material Sciences (2021), Young Scientist Conclave (2021) & Student Science Meet (2021) The 160th Birth Anniversary Celebration of Acharya Prafulla Chandra Ray 01-03 & 07-08 August, 2021 iii FOREWORD “International Seminar on Recent Advances in Chemistry and Material Sciences (2021), Young Scientist Conclave (2021) & Student Science Meet (2021)” is being organized by the Indian Chemical Society to commemorate the 160th Birth Anniversary of Acharya Prafulla Chandra Ray, the doyen of Chemical Sciences in India. This is 16th in the series of Symposium, the first one was held in 2006, as a part of Birth day celebration of Acharya Prafulla Chandra Ray, founder President of the Indian Chemical Society. The Indian Chemical Society, one of the oldest learned bodies of our national pride was established on May 09, 1924. Acharya P. C. Ray, after returning from Edinburgh first joined the Presidency College, Kolkata in 1889 and later in 1916, joined the Department of Chemistry, newly formed University College of Science, University of Calcutta as the Palit Professor of Chemistry. Acharya Ray was intimately associated with the Indian Chemical Society till the last breath. The school of modern chemical research established by Acharya Ray in the University College of Science, where he used to live in the later part of his life, subsequently spread over the entire country through his many illustrious disciples. Acharya Ray had always strongly advocated for effective interactions between industries and academia. He himself was the founder of Bengal Chemical and Pharmaceutical Works Ltd. Acharya Prafulla Chandra Ray was born on August 02, 1861. -
Year Book of the Indian National Science Academy
AL SCIEN ON C TI E Y A A N C A N D A E I M D Y N E I A R Year Book B of O The Indian National O Science Academy K 2019 2019 Volume I Angkor, Mob: 9910161199 Angkor, Fellows 2019 i The Year Book 2019 Volume–I S NAL CIEN IO CE T A A C N A N D A E I M D Y N I INDIAN NATIONAL SCIENCE ACADEMY New Delhi ii The Year Book 2019 © INDIAN NATIONAL SCIENCE ACADEMY ISSN 0073-6619 E-mail : esoffi [email protected], [email protected] Fax : +91-11-23231095, 23235648 EPABX : +91-11-23221931-23221950 (20 lines) Website : www.insaindia.res.in; www.insa.nic.in (for INSA Journals online) INSA Fellows App: Downloadable from Google Play store Vice-President (Publications/Informatics) Professor Gadadhar Misra, FNA Production Dr VK Arora Shruti Sethi Published by Professor Gadadhar Misra, Vice-President (Publications/Informatics) on behalf of Indian National Science Academy, Bahadur Shah Zafar Marg, New Delhi 110002 and printed at Angkor Publishers (P) Ltd., B-66, Sector 6, NOIDA-201301; Tel: 0120-4112238 (O); 9910161199, 9871456571 (M) Fellows 2019 iii CONTENTS Volume–I Page INTRODUCTION ....... v OBJECTIVES ....... vi CALENDAR ....... vii COUNCIL ....... ix PAST PRESIDENTS OF THE ACADEMY ....... xi RECENT PAST VICE-PRESIDENTS OF THE ACADEMY ....... xii SECRETARIAT ....... xiv THE FELLOWSHIP Fellows – 2019 ....... 1 Foreign Fellows – 2019 ....... 154 Pravasi Fellows – 2019 ....... 172 Fellows Elected (effective 1.1.2019) ....... 173 Foreign Fellows Elected (effective 1.1.2019) ....... 177 Fellowship – Sectional Committeewise ....... 178 Local Chapters and Conveners ...... -
Awardees of National Bioscience Award for Career Development
AWARDEES OF NATIONAL BIOSCIENCE AWARD FOR CAREER DEVELOPMENT Awardees for the year 2016 1. Dr. Mukesh Jain, Associate Professor, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067 2. Dr. Samir K. Maji, Associate Professor, Indian Institute of Technology, Powai, Mumbai- 400076 3. Dr. Anindita Ukil, Assistant Professor, Calcutta University, Kolkata 4. Dr. Arnab Mukhopadhyay, Staff Scientist V, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi- 110067 5. Dr. Rohit Srivastava, Professor, Indian Institute of Technology, Bombay, Mumbai- 400076 6. Dr. Pinaki Talukdar, Associate Professor, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pashan, Pune- 7. Dr. Rajnish Kumar Chaturvedi, Senior Scientist, CSIR- Indian Institute of Toxicology Research, Lucknow-226001 8. Dr. Jackson James, Scientist E-II, Neuro Stem Cell Biology Lab, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala- 695014 Awardees for the year 2015 1. Dr. Sanjeev Das, Staff Scientist-V, National Institute of Immunology, New Delhi 2. Dr. Ganesh Nagaraju, Assistant Professor, Department of Biotechnology, Indian Institute of Science, Bangalore- 5600012. 3. Dr. Suvendra Nath Bhattacharya, Principal Scientist, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032 4. Dr. Thulasiram H V, Principal Scientist, CSIR-National Chemical Laboratory, Pune- 411008. 5. Dr. Pawan Gupta, Principal Scientist, Institute of microbial Technology, Chandigarh- 160036. 6. Dr. Souvik Maiti, Principal Scientist, CSIR-Institute of Genomics and Integrative Biology, Delhi- 110025. 7. Dr. Pravindra Kumar, Associate Professor, Department of Biotechnology, IIT, Roorkee- 247667. 8. Dr. Anurag Agrawal, Principal Scientist, CSIR-Institute of Genomics and Integrative Biology, Delhi- 110025 9. Dr. Gridhar Kumar Pandey, Professor, Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi- 110067 10. -
Narendra Kumar, Phd Assistant Professor, Jaypee University of Information Technology, Solan Distt
Narendra Kumar, PhD Assistant Professor, Jaypee University of Information Technology, Solan Distt. HP +91 9891287635 [email protected] https://www.linkedin.com/in/narekum, https://narekum.github.io Summary n Interdisciplinary research background in Computational Biology, Molecular Structural Biology, Bioinformatics and Biochemistry. n Six years of postdoctoral experience in Biological Data Analysis (Protein sequence, small molecules, and NGS), Computational data modeling, Genome Arithmetic, Data mining and Large Scale Data Modeling with Python, Perl, R and Linux shell scripting. n Track record of bioinformatics software tool development, data analysis, and workflow design in computational screening for Genome Mining and Structure Biology. Work Experience Assistant Professor Dec 2017 to present Jaypee University of Information Technology, Solan, HP, INDIA n Teaching: Programming Languages, Structural Biology, Computational Genomics n Research: Genome Biology, Chromatin Structure Postdoctoral Computational Biologist Apr 2013 to Dec 2016 University of Glasgow, Glasgow, UK n Established computational biology setup in an experimental lab, including purchasing, installing and managing the computational infrastructure. n Developed Next Generation Sequencing analysis pipelines and tools for detecting DNA-binding sites, and RNA-seq based differential analysis in human genome. Postdoctoral Fellow Sep 2010 to Jan 2013 Georgia Institute of Technology, Atlanta, US n Developed EFICAz2.5, a sequence based enzyme function prediction server, and applied to 373 proteomes. n Structure modelling of whole enzyme complement of human proteome n Developed a computational metabolomics approach to identify differentially expressed metabolites. Research Associate Jan 2010 to Aug 2010 National Institute of Immunology, New Delhi, INDIA n Modelling of pfCDPK1 in active and inactive conformations in Plasmodium falciparum malarial parasite. -
National Bioscience Awards for Career Development
AWARDEES OF NATIONAL BIOSCIENCE AWARDS FOR CAREER DEVELOPMENT Awardees for the year 2012 1. Dr. Kaustuv Sanyal, Associate Professor, Molecular Mycology Laboratory, Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advance Scientific Research, Jakkur P.O. Bangalore 560064 2. Dr Naval Kishore Vikram, Associate Professor, Department of Medicine, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi- 110029 3. Dr. Aditya Bhushan Pant, Senior Scientist & In-charge, In Vitro Toxicology Laboratory, Indian Institute of Toxicology Research, PO Box: 80, MG Marg, Lucknow 226001 (UP) India 4. Dr. Subrata Adak, Senior Scientist, Indian Institute of Chemical Biology; 4, Raja S.C. Mullick Road, Kolkata-700032 5. Dr. Durai Sundar, Assistant Professor, Dept of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi – 110016 6. Dr S Venkata Mohan, Senior Scientist, Bioengineering and Environmental Centre (BEEC) CSIR-Indian Institute of Chemical Technology, Hyderabad-500 607 7. Dr. Munia Ganguli, Scientist E-I, CSIR-Institute of Genomics & Integrative Biology, Mall Road,New Delhi 110 007 8. Dr. Asad U Khan, Associate Professor & Coordinator/Head of Biotechnology Department, A.M.U, Interdisciplinary Biotechnology Unit, A.M.U., Aligarh 202002 9. Dr. Sathees C. Raghavan, Assistant Professor, Department of Biochemistry, Indian Institute of Science, Bangalore 560 012 10. Dr. Vidita A. Vaidya, Associate Professor, Department of Biological Sciences, Tata Institute of Fundamental Research, 1, Homi Bhabha Road, Colaba, Mumbai - 400005 Awardees for the year 2011 1. Dr. M. M. Parida, Scientist-F, Joint Director, Division of Virology Defence R & D Establishment, DRDE, DRDO, Ministry of Defence, Jhansi Road, Gwalior- 474002 2.