Curriculum Vitae

Curriculum vitae

PERSONAL INFORMATION Silvana Anna Maria Urru

24, Viale Europa, 08030 Meana Sardo (Nu) (Italy) (+39) 3934281150 [email protected] Skype Sam.80.

PERSONAL STATEMENT An enthusiastic, adaptive and fast-learning person with a broad and acute interest in the healthcare field, I particularly enjoy collaborating with people from different disciplines to develop new skills and solve new challenges. Main interest: public health, pharmacology and HTA.

WORK EXPERIENCE

22 Sep 2015–7 Dec 2018 Evaluation and monitoring of Public health and research innovation projects European Commission, Luxembourg (Luxembourg) Evaluation / assessment and monitoring of proposals under the Health programme call for proposals for projects 2015, 2016 and 2017.

6 Jul 2017–Present Hospital pharmacist S.Chiara Hospital_Azienda Provinciale per i Servizi Sanitari, Trento Researcher in clinical pharmacy Pharmacovigilance Project manager

1 Jun 2016–1 Jun 2017 Pharmaceutical researcher (collaborator) Health Regional Department, Sardinia Region, Cagliari (Italy) Drug use evaluation and collaboration in clinical pathway development (PDTA)

1 Sep 2010–5 Jul 2017 Research project manager CRS4_Building 1, Science and Technology Park Polaris, Piscina Manna, 09010 Pula (CA) - ITALY (Italy) Responsible for Good Clinical Practice, Data Collection, Integration and Protection. Experience with NGS and working with clinical oncology samples. Projects: Grant [Multiple Sclerosis Italian association, AISM] - Rational design of new candidate compounds for multiple sclerosis treatment based on analysis of biological targets identified through genome wide association studies in Sardinia. In collaboration with IRGB-CNR (Prof. Francesco Cucca) and ProgeNIA. Grant [Sardinia Region, Legge 7] Clinical trials - Molecular profiling of triple negative breast cancer and screening of new potential therapeutic agents acting on the ubiquitin-proteasome system. Multicenter study, in collaboration with main Oncological Hospitals in Sardinia. Responsible for Good Clinical Practice, Data Collection, Integration and Protection. - Identify the genetic bases for prominent age-associated changes, in a founder population in Sardinia (people aged 90-114 years). In collaboration with IRGB-CNR and NIA-NIH (Prof. Schlessinger, National Institute on Aging, USA) .

8 Nov 2017–Present College / university teaching professional

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Europa Cube, Milan Lecturer in European H2020 Funds and project evaluation

23 Jan 2013–1 Jan 2017 College / university teaching professional Medical Evidence, Milan (Italy) Lecturer in clinical pharmacy

1 Sep 2013–1 Dec 2013 Hospital pharmacist Antiblastic Drug Unit - Oncological Hospital, Cagliari (Italy) Monitoring medicines utilisation and expenditure; evaluation and monitoring of adverse drug reactions

1 Dec 2012–1 Dec 2016 Pharmacovigilance Executive team member of SIFAC Italian Clinical Pharmacy Society (Italy) Pharmacovigilance researcher Project manager epidemiological and observational studies in community pharmacies

1 Jan 2008–1 Jan 2010 PhD student IRCCS "Mario Negri" Pharmacological Institute, Milan (Italy)

1 Aug 2004–1 Jan 2005 Pharmacist Pharmacy open to public, Cagliari (Italy) 6 months placement as Pharmacist: counselling, preparation of drugs, selling. Developed communication and business awareness. Took the initiative to largely reorganize stock and improve its handling, learned team work, meeting deadlines and doing several works in parallel.

21 Jun 2016–Present Member of Register of Experts, Area 4: Clinical / Managerial / Epidemiological / Social and 5: Research and International Relations AGENAS, Rome

EDUCATION AND TRAINING

10 Feb 2015–11 Jun 2015 Master's degree in European Project Management Europa cube innovation business school, Cagliari (Italy) The course provided me the skills to successfully work in the field of European cooperation, through the use of fundings made available by the European Comission.

2 Jun 2014–21 Jul 2014 Data Management for Clinical Research course Vanderbilt University, Nashville (United States) Skill acquired: important concepts related to research data planning, collection, storage and dissemination. Instructors have give us important information and best-practice guidelines for 1) investigator-initiated and sponsored research studies, 2) single- & multi-center studies, and 3) prospective data collection & secondary-reuse of clinical data for purposes of research.

7 Apr 2014–20 Apr 2014 Medicines adherence: supporting patients with their treatment course King's College London, London (United Kingdom) This course helped me to learn how healthcare professionals can improve patient's health through

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their adherence to therapy

28 Oct 2013–13 Dec 2013 Health Technology Assessment MOOC certificate course Scheffield University, Scheffield (United Kingdom) This course has introduced me to Health Technology Assessment (HTA) as a concept and through the key stages in the HTA and decision-making process.

1 Dec 2005–16 Dec 2008 Ph.D. in Medicinal Chemistry EQF level 8 University of Cagliari - IRCCS "Mario Negri" Pharmacological Institute (Milan) - Italy, Cagliari (Italy)

1 Nov 1999–7 Nov 2005 Bachelor's degree in Medicinal Chemistry EQF level 7 University of Cagliari, Cagliari (Italy)

PERSONAL SKILLS

Mother tongue(s) Italian

Foreign language(s) UNDERSTANDING SPEAKING WRITING

Listening Reading Spoken interaction Spoken production English C1 C1 C1 C1 C1 Spanish C1 C1 B2 B2 B2 Levels: A1 and A2: Basic user - B1 and B2: Independent user - C1 and C2: Proficient user Common European Framework of Reference for Languages

Communication skills ▪ Excellent communication skills ▪ Good ability to adapt to multicultural environments, gained through my work experience abroad; ▪ Team spirit

Organisational / managerial skills ▪ Very high standards of accuracy and attention to detail ▪ Good organisational skills ▪ Good team-leading skills gained as project supervisor of 10 students of the International Master in Clinical Pharmacy.

Job-related skills ▪ Research skills: critical analysis of literature, data, conceptual thinking ▪ Fund-raising: seeking and succesfully preparing funding applications ▪ Management skills: managing time, projects, resources, people ▪ Problem-solving skills: designing, conducting experiments, troubleshooting ▪ Analysing results and data ▪ Presenting findings in scientific journals, books or at conferences ▪ Networking: collaboration with other groups (within and outside my department), industry, conferencing, organising seminars ▪ Strong work ethic ▪ Teaching

Digital skills Able to use the following: Operating systems: Windows XP, Windows NT, Windows ME, Windows 2000, Mac 0SX, Mac OS

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10.7 Software / Applications:Microsoft Office XP, Microsoft Office 2000, Microsoft Office 1997, MS Word, MS Access, MS Excel, MS FrontPage, MS Project, MS Visio, MS SiteServer, Internet Explorer, Outlook, Outlook Express, PowerPoint, Adobe Photoshop, Adobe Illustrator Databases: drugbank, pharmgkb, Therapeutic Target DB, Supertarget, clinicaltrial.gov, KEGG, PubChem, ChEMBLdb, OMIM, Gene atlas, NCIs db, Beilstein, Schifinder, Pubmed, Scopus, Cochrane Library

Driving licence B

ADDITIONAL INFORMATION

Publications Urru SA, Antonelli A, Sechi GM; MS Working Group. Prevalence of multiple sclerosis in Sardinia: A systematic cross-sectional multi-source survey. Mult Scler. 2019 Feb 22:1352458519828600. doi: 10.1177/1352458519828600. Piras D, Masala M, Delitala A, Urru SAM et al. Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population. Nephrol Dial Transplant. 2018 Aug 29. doi: 10.1093/ndt/gfy270 Urru S et al. "Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients". BMC cancer 2018. Jan 8;18(1):56. doi: 10.1186/s12885-017-3969-y. Angelucci E, Urru SA, Pilo F, Piperno A. Myelodysplastic Syndromes and Iron Chelation Therapy. Mediterr J Hematol Infect Dis. 2017 Mar1;9(1):e2017021 Pasina L, Urru SA, Mandelli S, Giua C, Minghetti P; SGCP Investigators. Evidence-based and unlicensed indications for proton pump inhibitors and patients' preferences for discontinuation: a pilot study in a sample of Italian community pharmacies. J Clin Pharm Ther. 2016 Mar 2. doi: 10.1111/jcpt.12371. Orrù S, Urru SAM, Murgia A, De Miglio MR, Cossu Rocca P, Sarobba G, Sollai E, Valle E. Immunohistochemical expression of fascin and androgen receptors in a comprehensive cohort of Triple-negative breast cancers. Abstract SIAPEC 2015 De Miglio MR, Sanges F, Ena S, Cossu S, Cossu Rocca P, Sarobba G, Moi T, Medda R, Urru S, Orrù S. p16INK4a and fascin as biomarkers in triple negative breast cancer. Abstract SIAPEC 2015 P. Cossu-Rocca, S. Orrù, M. R. Muroni, F. Sanges, S Ena, G. Pira, L. Murgia, A. Manca, M.G. Uras, S.A.M. Urru,G. Sarobba, M.R. De Miglio "Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer" PLoS One. 2015 Nov 5;10 Urru SAM,Pasina L, Minghetti P, Giua C, SGCP Investigators "Role of community pharmacists in the detection of potentially inappropriate benzodiazepines prescriptions for insomnia" IJCP Pasina L, Urru SAM, Minghetti P, Giua C, SGCP Investigators "Role of community pharmacies for the detection of potentially inappropriate xanthine oxidase inhibitor prescriptions" Drugs - Real World Outcomes Journal, 2015 Feb, doi: 10.1007/s40801-015-0016-7 Urru SAM, Tandurella I, Capasso M, Usala E, Baronciani D, Giardini C, Visani G, Angelucci E. Reproducibility of liver iron concentration measured on a biopsy sample: A validation study in vivo. Am J Hematol. 2014 Oct 27. doi: 10.1002/ajh.23878. Urru SAM, Mariotti E, Carta P, Massidda S, Marcias M, Murru R, Sanna P, Angelucci E. Acute pancreatitis following brentuximab vedotin therapy for refractory hodgkin lymphoma: a case report. Drugs R D. 2014 Mar;14(1):9-11. doi: 10.1007/s40268-014-0036-x. V. Orrù, M. Steri, G. Sole, C. Sidore, F. Virdis, M. Dei, S. Lai, M. Zoledziewska, F. Busonero, A. Mulas, M.Floris, W. I. Mentzen, S. A.M. Urru, S. Olla, M.Marongiu, M.G. Piras, M.Lobina, A. Maschio, M.Pitzalis, M. F. Urru, M. Marcelli, R. Cusano, F. Deidda, M. Oppo, R. Pilu, F. Reinier, R. Berutti, L. Pireddu, I. Zara, E. Porcu, A. Kwong, C. Brennan, B. Tarrier, R Lyons, H. M. Kang, S. Uzzau, R. Atzeni, M. Valentini, D.Firinu, L. Leoni, G. Rotta, S. Naitza, A. Angius, M. Congia, M. B. Whalen, C. M. Jones, D. Schlessinger, G. R. Abecasis, E. Fiorillo, S. Sanna, F. Cucca. Genetic variants regulating immune cell levels in health and disease Cell. 2013 Sep 26;155(1):242-56. doi: 10.1016/j.cell.2013.08.041. S.A.M. Urru, P. Veglianese, A. de Luigi, E. Fumagalli, E. Erba, R. G. Diaza, E. Davoli, T. Borsello, G. Forloni, N. Pengo, E. Monzani, Paolo Cascio, Simone Cenci, R. Sitia, M. Salmona A New Fluorogenic Peptide Determines Proteasome Activity in Single Cells Journal of Medicinal Chemistry 2010, Journal of Medicinal Chemistry. 2010, 53(20):7452-60.

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Begala M, Tocco G, Meli G, Podda G, Urru SA. Formation of 2-substituted benzofuran fragment ions from 6-alkyl- and 6-aryldibenzo(d,f)(1,3)dioxepine derivatives under electron ionization-a useful precursor ion for isomeric differentiation. J Mass Spectrom. 2009 Feb;44(2):245-51. doi: 10.1002/jms.1503. Begala, M., Tocco, G., Meli, G., Podda, G., Urru, S.A.M. "2-Substituted benzofuran fragment ion formation in the EI spectra of 6-alkyl and 6- aryldibenzo (d,f)(1,3) dioxepine derivatives" Rapid Commun. Mass Spectrom. 2007; 21: 1414-1420. Campomori A, Urru SAM, Cerù S., Aloisi T, Toldo Chandrakala2, Boni M, Laner B, Fonzi E., Grattarola M., Guella A "Percorso clinico condiviso di trattamento con imatinib equivalente nei pazienti affetti da leucemia mieloide cronica in carico alla struttura di Ematologia dell'APSS di Trento "Poster al XXVI Seminario nazionale di Farmacoepidemiologia_ISS. Dicembre 2017 Pani A, Piras D, Masala M, Atzeni A, Urru SAM, Delitala A, Schlessinger D and Cucca F CKD prevalence and use of formulas in oldest old individuals Poster Presentations at the American Society of Nephrology's Kidney Week 2014, Philadelphia, 11 16 Novembre, 2014 S. A.M. Urru, R. Medda, T. Moi, E. Sollai, F. Sanges, E. Valle, A. Bulfone, S. Orrù "Collection and systematic analisys of a comprehensive cohort of triple negative breast cancers in southern Sardinia" Congress of the Italian Society of Pathology 22-25 October 2014 Firenze Mariotti E, Carta P, Urru SAM, Marcias M, Sanna P "Contributo della segnalazione nella definizione del profilo di sicurezza di un nuovo farmaco oncologico: il ruolo del farmacista" Presentazione Poster XXXV Congresso della Società Italiana Farmacia Ospedaliera, 16-19 Ottobre, 2014 Urru SAM, E. Sanna, Virdis, L. Ferreli, G. Zedda, N.M.C. Curreli, M. G. Piras, M. Lobina, M. Marongiu, M. Floris, M. Steri, S. Sanna, M. Marongiu, A. Mulas, E. Fiorillo, V. Orrù, R. Galanello4, A. Atzeni, A. Pani, F. Cucca. A comprehensive phenotypic and genetic analysis of long-lived people from 13 villages located in the Sardinian region of Barbagia-Mandrolisai Presentazione Poster al meeting della ESHG European Society of Human Genetics, Norimberga. 23-26 Giugno 2012 Urru S.A.M. "Individual longevity versus population longevity: a comprehensive phenotypic and genetic analysis of centenarians from 13 villages located in the Sardinian Region of Barbagia- Mandrolisai" Korea-Italy Symposium on Genetic and non-genetic determinants of successful aging, Ottobre 2011 Urru SA, Veglianese P, De Luigi A, Fumagalli E, Erba E, Gonella Diaza R, Carrà A, Davoli E, Borsello T, Forloni G, Pengo N, Monzani E, Cascio P, Cenci S, Sitia R, Salmona M. A new fluorogenic peptide determines proteasome activity in single cells. Presentazione Poster al CSHL Meeting on The Ubiquitin Family- Cold Spring Harbor, New York, 17-21 Maggio 2011. Begala M, Delogu G, Meli G, Picciau C, Podda G, Tocco G, S.A.M. Urru Synthesis and Immobilization of Some Coumarins Resveratrols Analogues on Polyethylene glycol ; Presentazione Poster al VI Italian- Spanish Symposium, Taormina, 14-17 Luglio 2006 Michela Begala, Gianni Podda, Eugenio Uriarte, Dolores Vina, Silvana A.M. Urru Sintesi e comportamento spettrometrico di massa di 1-[2-(idrossimetil)cicolesil]pirimidine analoghi dei nucleosidi ; Presentazione Poster al XXII Congresso della Società Chimica Italiana, Firenze. 10-15 Settembre 2006. Silvana A.M. Urru Sintesi di Cumarine che inglobano nella loro struttura il nucleo del trans- resveratrolo; Comunicazione Flash al XXII Congresso della Società Chimica Italiana. Firenze, 10-15 Settembre 2006

Courses Analisi Costo Efficacia applicata ai nuovi farmaci

Certifications Basic Life Support and Defibrillation (BLSD) Certification

Memberships Cochrane Member since 2018 Italian Society for Clinical Pharmacy and Therapeutics (SIFACT) since 2017 American Society of Clinical Oncology (ASCO) since April 2015

Data treatment authorization I hereby authorise the use of my personal data in compliance with the Legislative Decree 30th June 2003, n. 196, "Personal Data Protection Code".

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Dichiarazione veridicità Consapevole che, ai sensi dell'artt. 46 e 47 del DPR 445/2000 e successive modifiche e integrazioni, le dichiarazioni mendaci, la falsità negli atti e l'uso di atti falsi sono punite ai sensi del Codice penale e delle leggi speciali vigenti in materia, dichiara sotto la propria responsabilità: che quanto dichiarato nel seguente curriculum vitae et studiorum comprensivo delle informazioni sulla produzione scientifica corrisponde a verità.