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Bmp Signaling Supports Primordial Germ Cell

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Bmp Signaling Supports Primordial Germ Cell BMP SIGNALING SUPPORTS PRIMORDIAL GERM CELL DEVELOPMENT BY REGULATING KIT LIGAND BY BRIAN MASON DUDLEY Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Dissertation Adviser: Kathleen Molyneaux, Ph.D. Department of Genetics CASE WESTERN RESERVE UNIVERSITY August 2010 CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the thesis/dissertation of _______________Brian Mason Dudley_________________ Candidate for the ___Ph.D.____ degree*. (Signed) ___Ron_Conlon, Ph.D.____________ (Chair of Committee) ___Michiko Watanabe, Ph.D._______ ___Brian Bai, Ph.D._______________ ___Kathleen Molyneaux, Ph.D.______ (Thesis Advisor) (Date) ___June 24, 2010_________________ * We also certify that written approval has been obtained for any proprietary material contained therein. Dedication I would like to dedicate this work to the following people: My parents Michael and Paula for all of their support throughout my education, they have always stressed the importance of education and helped motivate me through this process. To my brother Philip and sister Erin for moral support and for visiting whenever they had the chance. Also to my in laws, all of my friends, and Jasmine for providing entertainment away from school. Finally, and most of all I would like to dedicate this to my wife Colleen for being so supportive during my graduate work. She has been there to read over drafts, listen to talks (which only occasionally put her to sleep), keep me motivated, and help me relax and have fun. Getting though grad school was really a team effort and I could not have done any of it without the love and support of Colleen. I thank her and all my friends and family for ensuring that I will always have fond memories of my time as a Ph.D. student. 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