Phospholipids: Dynamic Signaling in Health and Disease (Preliminary Program Agenda) July 29 – August 03, 2018 Steamboat Springs, CO, USA

Organizers: Seth Field Julie Brill University of California, San Diego The Hospital for Sick Children, University of Toronto San Diego, CA Toronto, ON, Canada

Julie Saba Raymond Blind Children’s Hospital Oakland Research Institute, Vanderbilt University School of Medicine University of California, San Francisco Nashville, TN San Francisco, CA

30th Anniversary Celebration of Research

Lipid Boot Camp Meet the Experts Career Development Workshop

Beautiful Colorado 80’s Dance Party

Travel Awards! Poster Awards! Child Care Awards!

Meet the Experts Lewis Cantley Bertil Hille George Carman Lucio Cocco Ed Dennis Volker Haucke Vytas Bankaitis Julie Brill Alexandra Newton Richard Anderson Sharona Gordon Julie Saba Guangwei Du

Meet the Young Experts Ray Blind Brooke Emerling John Burke Aurelia Lewis

Meet the Publication Experts Ed Dennis (Editor in Chief, Journal of Lipid Research) George Carman (Associate Editor, Journal of Biological Chemistry) Sharona Gordon (Editor in Chief, Journal of General Physiology) Lucio Cocco (Editor in Chief, Advances in Biological Regulation)

17 May 2018 Science Signaling Nature Chemical Biology

Meet the Industry Experts Kacee Sims (Avanti) Paul Neilsen (Echelon) Jeff Johnson (Cayman) Technology

Sunday, July, 29, 2018

Time Title/Topic Event 4:00 p.m. – 9:00 p.m. Conference Registration 4:30 p.m. – 6:00 p.m. LIPID BOOT CAMP Chair: Ray Blind Part 1 Ray Blind, Ph.D., Vanderbilt University School of Medicine

Part 2 Amy Kiger, Ph.D., University of California, San Diego 6:00 p.m. – 7:00 p.m. Welcome Reception 7:00 p.m. – 8:00 p.m. DINNER 8:00 p.m. – 9:30 p.m. Opening Scientific Session / Chairs: Seth Field and Julie Brill Keynote Speaker

PI 3-: Linking , Lewis Cantley, Ph.D., Weill Cornell Resistance and Medical Center

Monday, July, 30, 2018

Time Title/Topic Event 7:30 a.m. – 1:00 p.m., Conference Registration 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. Scientific Session

PI5P: A Riddle Wrapped in an Chair: Lucia Rameh Enigma

Understanding the role of Lucia Rameh, Ph.D., Boston University PIP4kgamma/TORC1 signaling in School of Medicine pancreatic beta cells

Non-canonical Brooke Emerling, Ph.D., Sanford in the control of cellular lipid Burnham Prebys Medical Discovery and autophagy Institute

17 May 2018 PtdIns5P and Septins in Membrane Ama Gassama Diagne, Ph.D., Inserm, Remodelling, Cell Polarity and Liver France Diseases

Role of phosphoinositides and Jeremy Thorner, Ph.D., University of individual subunits in the assembly, California, Berkeley localization and function of Saccharomyces cerevisiae TORC2

Selected Short Talks

10:00 a.m. – 10:15 a.m. FASEB Sponsored Coffee Break 10:15 a.m. – 11:00 a.m. Photo Session during Coffee Break

12:00 p.m. – 1:00 p.m. LUNCH and Meet the Expert Meet the Experts Session Meet the Young Expert Meet the Industry Expert Meet the Publishing Expert 1:00 p.m. – 2:30 p.m. Career Development Workshop Moderator: Seth Field

How to Become a Prize Winning Bertil Hille, Ph.D. Scientist Lasker Award, Gairdner Award, etc. 2:30 p.m. – 4:00 p.m. Free time 4:00 p.m. – 6:00 p.m. Scientific Session

Diacylglycerol, Kinase C, Chair: Alexandra Newton and their Kin

Spatiotemporal Dynamics of Alexandra Newton, Ph.D., University of Signaling by C California, San Diego

Negative Control of the DAG/PKC Isabel Mérida, Ph.D., Spanish National Axis by Diacylglycerol Kinases Center for Biotechnology

PKC at the Leading Edge: Single Joseph Falke, Ph.D., University of Molecule Studies of Links Between Colorado, Boulder PKC and PI3K

Selected Short Talks

6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session

Tuesday, July, 31, 2018

Time Title/Topic Event 7:30 a.m. – 1:00 p.m., Conference Registration 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration Scientific Session 17 May 2018

New Technologies for Studying Chair: Takanari Inoue

Uncharacterized Functions of PI3K Takanari Inoue, Ph.D., Johns Hopkins School of Medicine

Membrane Phospholipids, Dynamics Richard Gross, Ph.D., Washington and Signaling Functions in the University in St. Louis Human Heart and Beyond

Conformational Sampling of Thomas Leonard, Ph.D., University of Membranes by AKT Controls its Vienna, Austria Activation and Inactivation

Selected Short Talks

12:00 p.m. – 1:00 p.m. LUNCH and Meet the Expert Meet the Experts Session Meet the Young Expert Meet the Industry Expert Meet the Publishing Expert 1:00 p.m. – 4:00 p.m. Free time/Optional Strawberry Hot Springs Excursion 4:00 p.m. – 6:00 p.m. Scientific Session

Role of Phospholipids in Membrane Chair: Volker Haucke Trafficking

Phosphoinositide conversion in the Volker Haucke, Ph.D., Leibniz-Instituts endolysosomal system für Molekulare Pharmakologie, Germany

Phosphoinositide Lipid Signaling in Scott Emr, Ph.D., Cornell University the regulation of membrane trafficking and identity

Coordination of Class II PI3-kinase Amy Kiger, Ph.D., University of and Mtm PI3- functions California, San Diego in membrane trafficking

Selected Short Talks

6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session

Wednesday, August, 01, 2018

Time a.m. – Time p.m. Title/Topic Event 7:30 a.m. – 1:00 p.m., Conference Registration 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. BREAKFAST

17 May 2018 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. Scientific Session

Expanding Roles for PI4P Chair: Tamas Balla

The Role of PI4KA in Controlling Tamas Balla, Ph.D., NICHD/NIH Membrane Lipid Dynamics

Identification of a pathway for Julie Brill, Ph.D., The Hospital for Sick PI4KII-dependent transport during Children, Canada secretory granule maturation

The Great Escape: How PtdIns(4)P Seth Field, M.D., Ph.D., University of and GOLPH3 promote vesicle exit California, San Diego from the Golgi (and how that drives cancer)

Selected Short Talks

10:00 a.m. – 10:15 a.m. FASEB Sponsored Coffee Break 12:00 p.m. – 12:30 p.m. Business Meeting 12:30 p.m. – 2:00 p.m. LUNCH and Meet the Expert Meet the Experts Session Meet the Young Expert Meet the Industry Expert Meet the Publishing Expert 2:00 p.m. – 4:00 p.m. Free time/Optional Hike 4:00 p.m. – 6:00 p.m. Scientific Session

Phospholipids in Viral and Bacterial Chair: Nihal Altan-Bonnet Pathogenesis

Phospholipids in Intercellular Nihal Altan-Bonnet, Ph.D., NHLBI, NIH Transmission of RNA Virus Populations

Investigation of the Role of Plasma Robert Stahelin, Ph.D., Purdue Membrane in Assembly and University Budding of Filoviruses

Selected Short Talks

6:00 p.m. – 7:00 p.m. Conference Registration 6:00 p.m. – 7:00 p.m. DINNER 7:00 p.m. – 9:00 p.m. Poster Session

17 May 2018

Thursday, August, 02, 2018

Time a.m. – Time p.m. Title/Topic Event 7:30 a.m. – 1:00 p.m., Conference Registration 4:00 p.m. – 6:00 p.m. 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 12:00 p.m. Conference Registration 9:00 a.m. – 12:00 p.m. Scientific Session

Lyso and Chair: Julie Saba

New insights into Julie Saba, M.D., Ph.D., phosphate lysase insufficiency CHORI/University of California, San syndrome (SPLIS), an inborn error of Francisco metabolism caused by failure to degrade sphingolipids

Targeting Sphingosine-1-Phosphate Bodo Levkau, Ph.D., Virginia as Osteoanabolic Therapy for Commonwealth University Osteoporosis

Sphingolipids in Immune System Life Victoria Blaho, Ph.D., Weill Cornell and Death Medical College

Role of phosphoinositides and Jeremy Thorner, Ph.D., University of individual subunits in the assembly, California, Berkeley localization and function of Saccharomyces cerevisiae TORC2

Selected Short Talks

10:00 a.m. – 10:15 a.m. FASEB Sponsored Coffee Break 12:00 p.m. – 12:30 p.m. Business Meeting 12:00 p.m. – 1:00 p.m. LUNCH and Meet the Expert Meet the Experts Session Meet the Young Expert Meet the Industry Expert Meet the Publishing Expert 1:00 p.m. – 4:00 p.m. Group Activity (optional) 4:00 p.m. – 6:00 p.m. Scientific Session

Featured Session on Phospholipid Chair: Bertil Hille Regulation of Transmembrane

Dynamic Plasma Membrane Pools of Bertil Hille, Ph.D., University of Phosphoinositides Regulate Washington Membrane Proteins

Reciprocal regulation among TRPV1 Sharona Gordon, Ph.D., University of ion channels and PI3K in Washington inflammatory hyperalgesia

17 May 2018

Modulation of KV7 channel Carlos Villalba-Galea, Ph.D., University deactivation by PI(4,5)P2 of the Pacific

Selected Short Talks

6:00 p.m. – 7:00 p.m. DINNER 9:00 p.m. – 12:00 a.m. Party Like It’s 1988

Friday, August, 03, 2018

Time a.m. – Time p.m. Title/Topic Event 7:30 a.m. – 9:00 a.m. Conference Registration 7:30 a.m. – 9:00 a.m. BREAKFAST 7:30 a.m. – 900 a.m. Conference Registration 9:00 a.m. Boxed Snacks to Go and DEPARTURES

END OF CONFERENCE

For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD 20814

www.faseb.org/src

17 May 2018